Toxic effect and mRNA mechanism of moon dust simulant induced pulmonary inflammation in rats
The objective of this study is to investigate the pattern and mechanism of lung inflammation induced by subacute exposure to moon dust simulants (MDS) in rats. SD rats were exposed to MDS and silica dioxide through oral and nasal inhalation for 6hours per day continuously for 15 days. Pathological analysis indicated that the toxicity of MDS was lower than that of silica dioxide. MDS led to a notable recruitment and infiltration of macrophages in the rat lungs. Material characterization and biochemical analysis revealed that SiO2, Fe2O3, and TiO2 could be crucial sources of MDS toxicity. The study revealed that MDS-induced ...
Source: Toxicology - April 15, 2024 Category: Toxicology Authors: Jintao Wang Yuan Xue Bin Wu Ming Lei Honglei Ma Xinxing He Qi Tan Jian Guan Wei Song Renfu Li Xinguang Cui Source Type: research
Toxic effect and mRNA mechanism of moon dust simulant induced pulmonary inflammation in rats
The objective of this study is to investigate the pattern and mechanism of lung inflammation induced by subacute exposure to moon dust simulants (MDS) in rats. SD rats were exposed to MDS and silica dioxide through oral and nasal inhalation for 6hours per day continuously for 15 days. Pathological analysis indicated that the toxicity of MDS was lower than that of silica dioxide. MDS led to a notable recruitment and infiltration of macrophages in the rat lungs. Material characterization and biochemical analysis revealed that SiO2, Fe2O3, and TiO2 could be crucial sources of MDS toxicity. The study revealed that MDS-induced ...
Source: Toxicology - April 15, 2024 Category: Toxicology Authors: Jintao Wang Yuan Xue Bin Wu Ming Lei Honglei Ma Xinxing He Qi Tan Jian Guan Wei Song Renfu Li Xinguang Cui Source Type: research
Nanomaterials-induced programmed cell death: Focus on mitochondria
Toxicology. 2024 Apr 12:153803. doi: 10.1016/j.tox.2024.153803. Online ahead of print.ABSTRACTNanomaterials are widely utilized in several domains, such as everyday life, societal manufacturing, and biomedical applications, which expand the potential for nanomaterials to penetrate biological barriers and interact with cells. Multiple studies have concentrated on the particular or improper utilization of nanomaterials, resulting in cellular death. The primary mode of cell death caused by nanotoxicity is programmable cell death, which includes apoptosis, ferroptosis, necroptosis, and pyroptosis. Based on our prior publicatio...
Source: Toxicology - April 14, 2024 Category: Toxicology Authors: Shijia Qiao Yiyuan Kang Xiner Tan Xinru Zhou Can Zhang Shulin Lai Jia Liu Longquan Shao Source Type: research
Nanomaterials-induced programmed cell death: Focus on mitochondria
Toxicology. 2024 Apr 12:153803. doi: 10.1016/j.tox.2024.153803. Online ahead of print.ABSTRACTNanomaterials are widely utilized in several domains, such as everyday life, societal manufacturing, and biomedical applications, which expand the potential for nanomaterials to penetrate biological barriers and interact with cells. Multiple studies have concentrated on the particular or improper utilization of nanomaterials, resulting in cellular death. The primary mode of cell death caused by nanotoxicity is programmable cell death, which includes apoptosis, ferroptosis, necroptosis, and pyroptosis. Based on our prior publicatio...
Source: Toxicology - April 14, 2024 Category: Toxicology Authors: Shijia Qiao Yiyuan Kang Xiner Tan Xinru Zhou Can Zhang Shulin Lai Jia Liu Longquan Shao Source Type: research
In Vitro Toxicological Evaluation of glo menthol and non-menthol Heated Tobacco Products
Toxicology. 2024 Apr 11:153801. doi: 10.1016/j.tox.2024.153801. Online ahead of print.ABSTRACTHeated tobacco products (HTPs) are non-combustible, inhaled tobacco products that generate an aerosol with fewer and lower levels of toxicants, with a potential to reduce risk relative to cigarette smoking. Here, we assessed in vitro toxicological effects of three menthol (glo neo neoCLICK, neo Smooth Menthol and Fresh Menthol) and one non-menthol (neo Smooth Tobacco) variants of glo HTP, along with market comparators for cigarettes and HTPs. Limited chemical characterization of the study products revealed significantly lower leve...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: Brian M Keyser Robert Leverette Reagan McRae John Wertman Tom Shutsky Kristen Jordan Ken Szeliga Patrudu Makena Source Type: research
The p21 < sup > + < /sup > perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration
Toxicology. 2024 Apr 12;504:153804. doi: 10.1016/j.tox.2024.153804. Online ahead of print.ABSTRACTFifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete ...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: David S Umbaugh Nga T Nguyen Sawyer H Smith Anup Ramachandran Hartmut Jaeschke Source Type: research
In Vitro Toxicological Evaluation of glo menthol and non-menthol Heated Tobacco Products
Toxicology. 2024 Apr 11:153801. doi: 10.1016/j.tox.2024.153801. Online ahead of print.ABSTRACTHeated tobacco products (HTPs) are non-combustible, inhaled tobacco products that generate an aerosol with fewer and lower levels of toxicants, with a potential to reduce risk relative to cigarette smoking. Here, we assessed in vitro toxicological effects of three menthol (glo neo neoCLICK, neo Smooth Menthol and Fresh Menthol) and one non-menthol (neo Smooth Tobacco) variants of glo HTP, along with market comparators for cigarettes and HTPs. Limited chemical characterization of the study products revealed significantly lower leve...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: Brian M Keyser Robert Leverette Reagan McRae John Wertman Tom Shutsky Kristen Jordan Ken Szeliga Patrudu Makena Source Type: research
The p21 < sup > + < /sup > Perinecrotic Hepatocytes Produce the Chemokine CXCL14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration
Toxicology. 2024 Apr 11:153804. doi: 10.1016/j.tox.2024.153804. Online ahead of print.ABSTRACTFifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete popu...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: David S Umbaugh Nga T Nguyen Sawyer H Smith Anup Ramachandran Hartmut Jaeschke Source Type: research
The effects of micro- and nanoplastic on the central nervous system: A New Threat to Humanity?
This article aims to provide a comprehensive overview of the knowledge of MNPs and the potential mechanisms of their impact on the central nervous system. Numerous in vivo and in vitro studies have shown that exposure to MNPs may pass through the blood-brain barrier (BBB) and lead to neurotoxicity through impairments in oxidative and inflammatory balance, neurotransmitter alternation, nerve conduction-related key enzymes, and impact through the gut-brain axis. It is worth noting that MNPs may act as carriers and have more severe effects on the body when co-exposed with other substances. MNPs of smaller sizes cause more sev...
Source: Toxicology - April 12, 2024 Category: Toxicology Authors: Yanxu Zheng Shengchao Xu Jingyu Liu Zhixiong Liu Source Type: research
Long-term use of etomidate disrupts the intestinal homeostasis and nervous system in mice
This study aimed to investigate the neurotoxic and gastrointestinal effects of ETO at doses of 1 mg/kg and 3 mg/kg in mice over 14 consecutive days. The results showed that long-term injection of ETO led to drug resistance in mice, affecting their innate preference for darkness and possibly inducing dependence on ETO. The levels of 5-hydroxytryptamine in the brain, serum, and colon decreased by 37%, 51%, and 42% respectively, while the levels of γ-aminobutyric acid reduced by 38%, 52%, and 41% respectively. H&E staining revealed that ETO reduced goblet cells in the colon and damaged the intestinal barrier. The express...
Source: Toxicology - April 11, 2024 Category: Toxicology Authors: Siming Ding Kan Li Xing Han Wenting Lin Yingjun Qin Renjuan Cao Yuan Ren Source Type: research
Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro
Toxicology. 2024 Apr 9:153800. doi: 10.1016/j.tox.2024.153800. Online ahead of print.ABSTRACTAcrylamide (ACR) is an endogenous food contaminant, high levels of ACR have been detected in a large number of foods, causing widespread concern. Since different organism states respond differently to the toxic effects of pollutants, this study establishes an insulin-resistant BRL cell model to explore the differential susceptibility of BRL cells with/without insulin resistance in response to acrylamide-exposure (0.0002, 0.02, or 1mM) toxicity effects and its mechanism. The results showed that ACR exposure decreased glucose uptake ...
Source: Toxicology - April 11, 2024 Category: Toxicology Authors: Yuchao Guo Houlin Mao Danni Gong Nuo Zhang Dandan Gu Emmanuel Sunday Okeke Weiwei Feng Yao Chen Guanghua Mao Ting Zhao Liuqing Yang Source Type: research
Long-term use of etomidate disrupts the intestinal homeostasis and nervous system in mice
This study aimed to investigate the neurotoxic and gastrointestinal effects of ETO at doses of 1mg/kg and 3mg/kg in mice over 14 consecutive days. The results showed that long-term injection of ETO led to drug resistance in mice, affecting their innate preference for darkness and possibly inducing dependence on ETO. The levels of 5-hydroxytryptamine in the brain, serum, and colon decreased by 37%, 51%, and 42% respectively, while the levels of γ-aminobutyric acid reduced by 38%, 52%, and 41% respectively. H&E staining revealed that ETO reduced goblet cells in the colon and damaged the intestinal barrier. The expressio...
Source: Toxicology - April 11, 2024 Category: Toxicology Authors: Siming Ding Kan Li Xing Han Wenting Lin Yingjun Qin Renjuan Cao Yuan Ren Source Type: research
Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro
Toxicology. 2024 Apr 9:153800. doi: 10.1016/j.tox.2024.153800. Online ahead of print.ABSTRACTAcrylamide (ACR) is an endogenous food contaminant, high levels of ACR have been detected in a large number of foods, causing widespread concern. Since different organism states respond differently to the toxic effects of pollutants, this study establishes an insulin-resistant BRL cell model to explore the differential susceptibility of BRL cells with/without insulin resistance in response to acrylamide-exposure (0.0002, 0.02, or 1mM) toxicity effects and its mechanism. The results showed that ACR exposure decreased glucose uptake ...
Source: Toxicology - April 11, 2024 Category: Toxicology Authors: Yuchao Guo Houlin Mao Danni Gong Nuo Zhang Dandan Gu Emmanuel Sunday Okeke Weiwei Feng Yao Chen Guanghua Mao Ting Zhao Liuqing Yang Source Type: research
Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice
This study will effectively address the deficiency in toxicological data pertaining to BPS. The novel BPS data obtained from this research can serve as a valuable reference for professionals in the field.PMID:38588857 | DOI:10.1016/j.tox.2024.153798 (Source: Toxicology)
Source: Toxicology - April 8, 2024 Category: Toxicology Authors: Yulang Chi Lin Zhu Yihui Wang Cai Peng Yi Lin Shouping Ji Jie Wei Source Type: research
Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice
This study will effectively address the deficiency in toxicological data pertaining to BPS. The novel BPS data obtained from this research can serve as a valuable reference for professionals in the field.PMID:38588857 | DOI:10.1016/j.tox.2024.153798 (Source: Toxicology)
Source: Toxicology - April 8, 2024 Category: Toxicology Authors: Yulang Chi Lin Zhu Yihui Wang Cai Peng Yi Lin Shouping Ji Jie Wei Source Type: research
