Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells
Toxicol Lett. 2024 Apr 15:S0378-4274(24)00067-5. doi: 10.1016/j.toxlet.2024.04.002. Online ahead of print.ABSTRACTMitochondrial fatty acid oxidation (mtFAO) plays an important role in hepatic energy metabolism. Severe mtFAO injury leads to nonalcoholic fatty liver disease (NAFLD) and liver failure. Several drugs have been withdrawn owing to safety issues, such as induction of fatty liver disease through mtFAO disruption. For instance, the antimicrobial triclocarban (TCC), an environmental contaminant that was removed from the market due to its unknown safety in humans, induces NAFLD in rats and promotes hepatic FAO in mice...
Source: Toxicology Letters - April 17, 2024 Category: Toxicology Authors: Hitoshi Nakamura Toshikatsu Matsui Tadahiro Shinozawa Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production ...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6;396:1-10. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production ...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6:S0378-4274(24)00055-9. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their lo...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6:S0378-4274(24)00055-9. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their lo...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6:S0378-4274(24)00055-9. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their lo...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The fentanyl-specific antibody FenAb024 can shield against carfentanil effects
Toxicol Lett. 2024 Apr 6:S0378-4274(24)00055-9. doi: 10.1016/j.toxlet.2024.03.008. Online ahead of print.ABSTRACTThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their lo...
Source: Toxicology Letters - April 8, 2024 Category: Toxicology Authors: Katharina Urban Anastasia Gkeka Monica Chandra Dennis Greiner Selina Pollich Sandra Ruf Yosip Kelemen Tom Sundermann Marco Pravetoni Carly Baehr C Erec Stebbins F Nina Papavasiliou Joseph P Verdi Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chenshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chenshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
