Endo ‐lysosomal sorting of G‐protein‐coupled receptors by ubiquitin: Diverse pathways for G‐protein‐coupled receptor destruction and beyond
Ubiquitination of GPCRs and endocytic adaptor proteins facilitates GPCR trafficking to lysosomes and. In addition, ubiquitination of GPCRs and GPCR effectors can mediate the activation of specific signaling pathways. GPCR ubiquitination is also critical for targeting some GPCRs for degradation by proteasomes. This review highlights the multiple pathways by which ubiquitin controls GPCR endo ‐lysosomal sorting and signaling, which expand the function of ubiquitin in regulating GPCR biology. Ubiquitin is covalently attached to substrate proteins in the form of a single ubiquitin moiety or polyubiquitin chains and has been ...
Source: Traffic - November 18, 2018 Category: Research Authors: Michael R. Dores,
JoAnn Trejo Tags: REVIEW Source Type: research
The use of quantitative imaging to investigate regulators of membrane trafficking in Arabidopsis stomatal closure
This article is protected by copyright. All rights reserved. (Source: Traffic)
Source: Traffic - November 16, 2018 Category: Research Authors: Gildas Bourdais,
Deirdre H. McLachlan,
Lydia M. Rickett,
Ji Zhou,
Agnieszka Siwoszek,
Heidrun H äweker,
Matthew Hartley,
Hannah Kuhn,
Richard J. Morris,
Dan MacLean,
Silke Robatzek Tags: TOOLBOX Source Type: research
Vesicle trafficking pathways that direct cell migration in 3D matrices and in vivo
Vesicle trafficking pathways control the delivery of cargos to and from the plasma membrane, and thus regulate their availability. Here, we review the function of endocytic trafficking in mediating the cell surface localization and local activity, through spatial restriction, of key cargoes that drive cell migration and invasion in three ‐dimensional matrix and in vivo. Cell migration is a vital process in development and disease, and while the mechanisms that control motility are relatively well understood on two ‐dimensional surfaces, the control of cell migration in three dimensions (3D) and in vivo has only recentl...
Source: Traffic - November 15, 2018 Category: Research Authors: Beverley J. Wilson,
Jennifer L. Allen,
Patrick T. Caswell Tags: REVIEW Source Type: research
Issue Information
Traffic, Volume 19, Issue 12, Page 895-897, December 2018. (Source: Traffic)
Source: Traffic - November 15, 2018 Category: Research Tags: ISSUE INFORMATION Source Type: research
Rab ‐mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity
This article is protected by copyright. All rights reserved. (Source: Traffic)
Source: Traffic - November 14, 2018 Category: Research Authors: Elodie Prince,
Benjamin Kroeger,
Dragan Gligorov,
Clive Wilson,
Suzanne Eaton,
Fran çois Karch,
Marko Brankatschk,
Robert K. Maeda Tags: ORIGINAL ARTICLE Source Type: research
Mechanisms of the Anterograde Trafficking of GPCRs: Regulation of AT1R Transport by Interacting Proteins and Motifs
This article is protected by copyright. All rights reserved. (Source: Traffic)
Source: Traffic - November 13, 2018 Category: Research Authors: Maoxiang Zhang,
Guangyu Wu Tags: REVIEW Source Type: research
Phosphatidylinositol 4 ‐phosphate on Rab7‐positive autophagosomes revealed by the freeze‐fracture replica labeling
This article is protected by copyright. All rights reserved. (Source: Traffic)
Source: Traffic - November 13, 2018 Category: Research Authors: Yuna Kurokawa,
Akane Yoshida,
Emi Fujii,
Kanna Tomioku,
Hiroki Hayashi,
Kenji Tanabe,
Akikazu Fujita Tags: ORIGINAL ARTICLE Source Type: research
CRISPR/Cas9 ‐mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish
This article is protected by copyright. All rights reserved. (Source: Traffic)
Source: Traffic - November 8, 2018 Category: Research Authors: Zhangji Dong,
Shuwen Wu,
Chenwen Zhu,
Xueting Wang,
Yuanyuan Li,
Xu Chen,
Dong Liu,
Liang Qiang,
Peter W. Baas,
Mei Liu Tags: ORIGINAL ARTICLE Source Type: research
PF11 Alleviates Oligomeric β‐Amyloid‐Induced Endosome‐Lysosome Defects in Microglia
Traffic,Volume 0, Issue ja, -Not available-. (Source: Traffic)
Source: Traffic - October 30, 2018 Category: Research Authors: Xue Chun Yao,
Xue Xue,
Hao Tian Zhang,
Ming Ming Zhu,
Xiao Wei Yang,
Chun Fu Wu,
Jing Yu Yang Source Type: research
Endo ‐lysosomal Sorting of G Protein‐coupled Receptors by Ubiquitin: Diverse Pathways for GPCR Destruction and Beyond
Traffic,Volume 0, Issue ja, -Not available-. (Source: Traffic)
Source: Traffic - October 24, 2018 Category: Research Authors: Michael R. Dores,
JoAnn Trejo Source Type: research
Prominin ‐1 (CD133) modulates the architecture and dynamics of microvilli
Traffic,Volume 0, Issue ja, -Not available-. (Source: Traffic)
Source: Traffic - October 17, 2018 Category: Research Authors: Kristina Thamm,
Deimant ė Šimaitė,
Jana Karbanová,
Vicente Bermúdez,
Doreen Reichert,
Anne Morgenstern,
Martin Bornhäuser,
Wieland B. Huttner,
Michaela Wilsch‐Bräuninger,
Denis Corbeil Source Type: research
Issue Information
Traffic,Volume 19, Issue 11, Page 799-801, November 2018. (Source: Traffic)
Source: Traffic - October 16, 2018 Category: Research Source Type: research
Lysosome: The Metabolic Signaling Hub
Traffic,Volume 0, Issue ja, -Not available-. (Source: Traffic)
Source: Traffic - October 11, 2018 Category: Research Authors: Dudley W. Lamming,
Liron Bar ‐Peled Source Type: research
The large GTPase Mx1 binds KIF5B for cargo transport along microtubules
Traffic,Volume 0, Issue ja, -Not available-. (Source: Traffic)
Source: Traffic - September 24, 2018 Category: Research Authors: Karina Ringer,
Jana Riehl,
Manuel M üller,
Jenny Dewes,
Florian Hoff,
Ralf Jacob Source Type: research
TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP) ‐associated proteins
Traffic, EarlyView. (Source: Traffic)
Source: Traffic - September 24, 2018 Category: Research Authors: Michael Sacher,
Nassim Shahrzad,
Hiba Kamel,
Miroslav P. Milev Source Type: research
