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Spectral Domain Optical Coherence Tomography for Glaucoma (An AOS Thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: At its current development state, SD-OCT shows better reproducibility than TD-OCT, but glaucoma discrimination is similar for TD-OCT and SD-OCT. Technological improvements are likely to enhance SD-OCT reproducibility, sensitivity, specificity, and utility, but these will require additional development. PMID: 19277249 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2008 Category: Opthalmology Authors: Schuman JS Tags: Trans Am Ophthalmol Soc Source Type: journals

Thermoresponsive Hydrogels as a New Ocular Drug Delivery Platform to The Posterior Segment of the Eye.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Thermoresponsive hydrogels were successfully synthesized and exhibited fast and reversible phase changes. The gel was able to encapsulate and release various proteins. Current formulation of the gel will be modified to extend the release time and to be made fully biodegradable. Thermoresponsive hydrogels appear to be a promising, minimally invasive platform for extended drug delivery to the posterior segment. PMID: 19277236 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2008 Category: Opthalmology Authors: Kang Derwent JJ, Mieler WF Tags: Trans Am Ophthalmol Soc Source Type: journals

Temperature Instability of ReNu with MoistureLoc: A New Theory to Explain the Worldwide Fusarium Keratitis Epidemic of 2004-2006.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: When exposed to prolonged temperature elevation, ReNu ML loses its in vitro fungistatic activity to a much greater extent than other products. Improper temperature control of ReNu ML may have contributed to the Fusarium keratitis epidemic of 2004-2006. PMID: 19277227 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2008 Category: Opthalmology Authors: Bullock JD, Warwar RE, Elder BL, Northern WI Tags: Trans Am Ophthalmol Soc Source Type: journals

Congenital Aberrant Tearing: A Re-Look.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Congenital anomalous lacrimation is rare but usually associated with Duane syndrome or abduction deficits, as in Möbius sequence and, less frequently, facial nerve palsy. Studies implicate an early insult in development at 4 to 6 weeks. At that time the facial nerve, sixth nerve, and lacrimal nucleus are in close proximity in the embryo. PMID: 19277226 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2008 Category: Opthalmology Authors: Miller MT, Strömland K, Ventura L Tags: Trans Am Ophthalmol Soc Source Type: journals

TOPOGRAPHICALLY GUIDED LASIK FOR MYOPIA USING THE NIDEK CXII CUSTOMIZED ASPHERIC TREATMENT ZONE (CATZ).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Nidek CXIII CATz treatment of myopia with astigmatism is safe, efficacious, and predictable, and it reduces patient symptoms associated with night driving and glare and halo symptoms. PMID: 18427614 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Waring G, Dougherty PJ, Chayet A, Fischer J, Fant B, Stevens G, Bains HS Tags: Trans Am Ophthalmol Soc Source Type: journals

THE GOAL OF VALUE-BASED MEDICINE ANALYSES: COMPARABILITY. THE CASE FOR NEOVASCULAR MACULAR DEGENERATION.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The majority of cost-utility studies performed on interventions for neovascular macular degeneration are value-based medicine studies and thus are comparable. Value-based analyses of neovascular ARMD monotherapies demonstrate the power of value-based medicine to improve quality of care and concurrently maximize the efficacy of healthcare resource use in public policy. The comparability of value-based medicine cost-utility analyses has important implications for overall practice standards and public policy. The adoption of value-based medicine standards can greatly facilitate the goal of higher-quality care and...
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Brown GC, Brown MM, Brown HC, Kindermann S, Sharma S Tags: Trans Am Ophthalmol Soc Source Type: journals

ASSOCIATION BETWEEN THYROID-STIMULATING IMMUNOGLOBULIN LEVELS AND OCULAR FINDINGS IN PEDIATRIC PATIENTS WITH GRAVES DISEASE.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A positive association exists between elevated initial levels of TSI and the development of Graves ophthalmopathy in children with Graves disease. PMID: 18427604 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Acuna OM, Athannassaki I, Paysse EA Tags: Trans Am Ophthalmol Soc Source Type: journals

MACULAR HOLES AND MACULAR PUCKER: THE ROLE OF VITREOSCHISIS AS IMAGED BY OPTICAL COHERENCE TOMOGRAPHY/SCANNING LASER OPHTHALMOSCOPY.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Vitreoschisis was detected in about half of all eyes with macular hole and macular pucker. The topographic and structural features in eyes with macular hole with retinal contraction differed in comparison to eyes with macular pucker alone, suggesting that although each condition may begin with anomalous PVD, differences in subsequent cell migration and proliferation probably result in the different clinical appearances detected in this study. PMID: 18427601 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Sebag J, Gupta P, Rosen RR, Garcia P, Sadun AA Tags: Trans Am Ophthalmol Soc Source Type: journals

QUANTITATIVE EVALUATION OF ANTERIOR SEGMENT PARAMETERS IN THE ERA OF IMAGING.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Quantitative measurement of static and dynamic anterior segment parameters, both normal and abnormal, provides a broad range of parameters for analysis of the numerous aspects of the pathophysiology of the anterior segment of the eye. PMID: 18427599 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Dorairaj S, Liebmann JM, Ritch R Tags: Trans Am Ophthalmol Soc Source Type: journals

HUMAN HtrA1 IN THE ARCHIVED EYES WITH AGE-RELATED MACULAR DEGENERATION.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study successfully analyzes HtrA1 SNP and transcript expression in microdissected cells from archived paraffin fixed slides. Up-regulation of HtrA1 is detected in the macular lesions of AMD eyes. The data further suggest that rs11200638 in HtrA1 promoter is associated with AMD development. PMID: 18427598 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Chan CC, Shen D, Zhou M, Ross RJ, Ding X, Zhang K, Green WR, Tuo J Tags: Trans Am Ophthalmol Soc Source Type: journals

PLUS DISEASE IN RETINOPATHY OF PREMATURITY: AN ANALYSIS OF DIAGNOSTIC PERFORMANCE.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Agreement and accuracy of plus disease diagnosis among ROP experts are imperfect. A computer-based system has potential to perform with comparable or better accuracy than human experts, but further validation is required. PMID: 18427596 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Chiang MF, Gelman R, Jiang L, Martinez-Perez ME, Du YE, Flynn JT Tags: Trans Am Ophthalmol Soc Source Type: journals

CHROMOSOME 3 ANALYSIS OF UVEAL MELANOMA USING FINE-NEEDLE ASPIRATION BIOPSY AT THE TIME OF PLAQUE RADIOTHERAPY IN 140 CONSECUTIVE CASES.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: FNAB provides adequate DNA in most cases for genetic analysis of uveal melanoma using microsatellite assay. PMID: 18427593 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Shields CL, Ganguly A, Materin MA, Teixeira L, Mashayekhi A, Swanson LA, Marr BP, Shields JA Tags: Trans Am Ophthalmol Soc Source Type: journals

AN EVALUATION OF HOW GLAUCOMA PATIENTS USE TOPICAL MEDICATIONS: A PILOT STUDY.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although most individuals may have little difficulty with the use, storage, and handling of eye drops, this study demonstrates that broad variation in reported practices exists. This finding suggests a need for better instruction in eye drop administration and illuminates some of the methodological problems that could be overcome to reduce patients' frustration, improve compliance, and increase efficacy. PMID: 18427591 [PubMed - as supplied by publisher]
Source: Transactions of the American Ophthalmological Society - December 1, 2007 Category: Opthalmology Authors: Tsai T, Robin AL, Smith JP Tags: Trans Am Ophthalmol Soc Source Type: journals

The incidence of symptomatic acquired lacrimal outflow obstruction among residents of olmsted county, Minnesota, 1976-2000 (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: SALOO incidence increased during the study interval, although a possible plateau effect was noted during the last 5 years of the study period. The majority of patients were female above the age of 66 years. The latter finding, in conjunction with US demographic trends, suggests that the frequency of SALOO may continue to increase in the future. External dacryocystorhinostomy appeared to be effective in the management of nasolacrimal duct obstruction. PMID: 18427633 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: J J, Woog Tags: Trans Am Ophthalmol Soc Source Type: journals

Visual morbidity in thirty-four families with schnyder crystalline corneal dystrophy (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although excellent scotopic vision continues until middle age in SCCD, most patients had PKP by the 7th decade. SCCD causes progressive corneal opacification, which may result in glare and disproportionate loss of photopic vision. PMID: 18427632 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Weiss JS Tags: Trans Am Ophthalmol Soc Source Type: journals

Computer-assisted quantification of vascular tortuosity in retinopathy of prematurity (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ROPtool has excellent sensitivity and overall accuracy relative to expert consensus in the detection of tortuosity sufficient for plus disease. Computer-assisted analysis of retinal images has the potential to remove subjectivity from the determination of plus disease and to optimize the timing of follow-up and treatment for ROP. PMID: 18427631 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Wallace DK Tags: Trans Am Ophthalmol Soc Source Type: journals

Causing and curing infantile esotropia in primates: the role of decorrelated binocular input (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Binocular decorrelation is a sufficient cause of infantile esotropia when imposed during a critical period of visuomotor development. The systematic relationship between severity of visuomotor sign, and severity of V1 connectivity deficit, provides a neuroanatomic mechanism for several of these signs. Restoration of binocular fusion and V1 connections, after short durations of decorrelation, helps explain the benefits of early repair in human strabismus. PMID: 18427630 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Tychsen L Tags: Trans Am Ophthalmol Soc Source Type: journals

Endothelial keratoplasty: clinical outcomes in the two years following deep lamellar endothelial keratoplasty (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: DLEK provides improved vision and minimal refractive astigmatic change, but progressive ECD decrease over time is of concern. PMID: 18427629 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Terry MA Tags: Trans Am Ophthalmol Soc Source Type: journals

Preventing surgical confusions in ophthalmology (an american ophthalmolgical society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Surgical confusions occur infrequently and usually cause little or no permanent injury, but they may be devastating to the patient, the physician, and the profession. Measures to prevent such confusions, including the Universal Protocol and related checklists, deserve the acceptance, support, and active participation of ophthalmologists. PMID: 18427628 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Simon JW Tags: Trans Am Ophthalmol Soc Source Type: journals

The graded levator hinge procedure for the correction of upper eyelid retraction (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The graded levator hinge procedure, alone or in combination with a Müllerectomy and/or lateral canthoplasty, is a safe and highly effective surgical approach for the treatment of various causes of upper eyelid retraction. Through consideration of the various anatomical and pathophysiological causes of eyelid retraction, excellent functional and cosmetic results are achieved with a graded procedure tapered to the needs of each individual. PMID: 18427627 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Schaefer DP Tags: Trans Am Ophthalmol Soc Source Type: journals

Malpractice and the quality of care in retinopathy of prematurity (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Negligent errors are common in malpractice cases that proceed to disposition. There are a limited number of repetitive errors that produce malpractice. An explanation of how these errors occur, coupled with the pertinent pathophysiology, afford an excellent opportunity to improve patient care. PMID: 18427626 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Reynolds JD Tags: Trans Am Ophthalmol Soc Source Type: journals

Impact of a pay-for-performance intervention: financial analysis of a pilot program implementation and implications for ophthalmology (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this pilot, implementing the program was an effective way to reduce the total health care costs in the first year of implementation. This supports the concept and documents for the first time in a commercial population that an appropriately designed pay-for-performance system can reduce total health care costs by reduction in units of service. This reduction in units of service will more than offset a substantive increase in physician payment per unit of service. Pay-for-performance measures will impact the practice of ophthalmology as government, payers, employers, and consumers focus on value and on demon...
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Parke DW Tags: Trans Am Ophthalmol Soc Source Type: journals

A prospective study of cavernous sinus surgery for meningiomas and resultant common ophthalmic complications (an american ophthlamological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Cavernous sinus surgery results in transient worsening of third, fourth, fifth, and sixth cranial nerve function. Cavernous sinus surgery carries a high risk of worsening ocular motor disorders and producing new ones. Preexisting cranial nerve dysfunction (other than optic nerve) rarely improves. Patients and physicians should be aware of the potential for ophthalmic complications in addition to the more generalized risks of neurosurgery (eg, cerebrospinal fluid leak, infection, stroke). PMID: 18427624 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Newman S Tags: Trans Am Ophthalmol Soc Source Type: journals

Mechanisms of retinal ganglion specific-cell death in leber hereditary optic neuropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results demonstrate that RGC-5 mitochondria produce superoxide at significantly lower rates than brain mitochondria. Tighter regulation of superoxide levels in RGCs would prevent aberrant apoptosis signaling. LHON mtDNA mutations may interfere with superoxide regulation, possibly leading to aberrant RGC death and consequent optic neuropathy. PMID: 18427623 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Levin LA Tags: Trans Am Ophthalmol Soc Source Type: journals

Suppression of keratoepithelin and myocilin by small interfering RNA (an american opthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: KE- or myocilin-specific shRNAs could effectively suppress the expression of recombinant KE or myocilin proteins and the related cytotoxicity of mutant myocilins. RNA interference may have future therapeutic implications in suppressing these genes. PMID: 18427622 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Huang AJ Tags: Trans Am Ophthalmol Soc Source Type: journals

A reconsideration of anterior chamber flare and its clinical relevance for children with chronic anterior uveitis (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Flare may be useful in the evaluation and management of chronic anterior uveitis in children. Flare is a marker of disease severity and is predictive of adverse events during the course of disease. PMID: 18427621 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Holland GN Tags: Trans Am Ophthalmol Soc Source Type: journals

Comparison of topical interleukin-1 vs tumor necrosis factor-alpha blockade with corticosteroid therapy on murine corneal inflammation, neovascularization, and transplant survival (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Topical IL-1Ra and prednisolone are comparable in their capacity to promote graft survival. sTNFR therapy, though effective, has much lower efficacy as compared to IL-1Ra or Pred. Combination IL-1Ra and steroid therapy offers only minimal added efficacy over either agent used alone. PMID: 18427620 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Dana R Tags: Trans Am Ophthalmol Soc Source Type: journals

Sources of binocular suprathreshold visual field loss in a cohort of older women being followed for risk of falls (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Severe binocular visual field loss due primarily to cataracts, glaucoma, and age-related macular degeneration explains 33.3% of the falls among women who fell frequently. Because binocular visual field loss may be treatable and/or preventable, screening programs for binocular visual field loss and subsequent referral for intervention and treatment are recommended as a strategy for preventing falls among the elderly. PMID: 18427619 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Coleman AL Tags: Trans Am Ophthalmol Soc Source Type: journals

Hanging by a thread: the long-term efficacy and safety of transscleral sutured intraocular lenses in children (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Transscleral fixation of an IOL in a child appears to be a safe and effective procedure provided that the suture material used is stable enough to resist significant degradation over time. Caution should be exercised in the use of 10-0 polypropylene suture to fixate an IOL to the sclera in children, and an alternative material or size should be considered. PMID: 18427618 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Buckley EG Tags: Trans Am Ophthalmol Soc Source Type: journals

Dissociated horizontal deviation: clinical spectrum, pathogenesis, evolutionary underpinnings, diagnosis, treatment, and potential role in the development of infantile esotropia (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Using reversed fixation testing, dissociated horizontal deviation can be detected in 50% of patients who develop consecutive exotropia following surgery for infantile esotropia. In this setting, monocular fixation with either eye superimposes a dissociated esotonus upon a baseline exodeviation. Fixation with the nonpreferred eye usually exerts greater esotonus than fixation with the preferred eye, producing an asymmetrical exodeviation during prism and alternate cover testing. Depending on the baseline anatomical position of the eyes, this dissociated esotonus can manifest as an intermittent exodeviation or an...
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Brodsky MC Tags: Trans Am Ophthalmol Soc Source Type: journals

Monocular diplopia due to spherocylindrical refractive errors (an american ophthalmological society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Monocular diplopia due to ordinary refractive errors can be predicted from diffraction theory. Higher-order aberrations-such as spherical aberration-are not necessary but may, under some circumstances, enhance the features of monocular diplopia. The physical basis for monocular diplopia is relatively subtle, and enhancement by neural processing is probably needed to account for the robustness of the percept. PMID: 18427616 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Archer SM Tags: Trans Am Ophthalmol Soc Source Type: journals

Posters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 18427615 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Tags: Trans Am Ophthalmol Soc Source Type: journals

Aqueous humor dynamics in monkeys in response to the kappa opioid agonist bremazocine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The IOP response to high doses of BRE in monkeys can be attributed to peripheral or central effects on MAP. The IOP-lowering response to topical BRE is due to aqueous humor flow suppression via non-opioid receptor stimulation. Some components of the IOP response are mediated by unknown mechanisms. PMID: 18427613 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Rasmussen CA, Gabelt BT, Kaufman PL Tags: Trans Am Ophthalmol Soc Source Type: journals

How effectively does medical care achieve its purposes? Evaluation of peer-reviewed literature in ophthalmology related to wellness.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: On the basis of a review of the literature and of over 1000 articles, ophthalmologists do not appear to give much priority to issues of quality of life or health. How validly these conclusions can be generalized to general clinicians is not known. PMID: 18427612 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Spaeth GL, Monteiro de Barros DS, Gheith M, Siam GA, Nagarsheth M Tags: Trans Am Ophthalmol Soc Source Type: journals

Central corneal opacification resulting from recent chemotherapy in corneal donors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Corneas from donors who received a full course of recent systemic antimetabolite therapy are associated with central subepithelial scarring following keratoplasty. Corneal surgeons should be aware of the potential for severe ocular surface disease when using donor tissue from patients with metastatic cancer. PMID: 18427611 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Van Meter WS Tags: Trans Am Ophthalmol Soc Source Type: journals

The effect of internal limiting membrane removal and indocyanine green on the success of macular hole surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Removal of the ILM decreases persistent and recurrent macular holes. ICG staining and complete removal of the ILM slows the rate of visual recovery but does not appear to have any long-term deleterious effect on the results of macular hole surgery. PMID: 18427610 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Thompson JT Tags: Trans Am Ophthalmol Soc Source Type: journals

Improving the risk-benefit relationship and informed consent for patients treated with hydroxychloroquine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A significant number of veterans taking HCQ may be at an increased risk for retinal toxicity. More than one-third of these patients may not be managed as recommended by the AAO. Methods to minimize these risks and improve informed consent are outlined. PMID: 18427609 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Flach AJ Tags: Trans Am Ophthalmol Soc Source Type: journals

Keratocyte and subbasal nerve density after penetrating keratoplasty.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Keratocyte density and number of keratocytes are decreased in penetrating grafts compared to normal corneas, but not compared to grafts with LEF. Subbasal nerve density does not recover to normal through 30 years after PK. PMID: 18427608 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Patel SV, Erie JC, McLaren JW, Bourne WM Tags: Trans Am Ophthalmol Soc Source Type: journals

Fundus autofluorescence of choroidal melanocytic lesions and the effect of treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Choroidal melanocytic lesions with overlying lipofuscin and hyperpigmentation are associated with increased FAF in about 90% of cases. Fundus autofluorescence photography may be helpful in evaluating small melanocytic tumors, since lipofuscin is a risk factor for growth. Following treatment, choroidal melanomas may show increased FAF. PMID: 18427607 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Gündüz K, Pulido JS, Bakri SJ, Amselem L, Petit-Fond E, Link T Tags: Trans Am Ophthalmol Soc Source Type: journals

Acquired ocular motor apraxia after aortic surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Acquired ocular motor apraxia with profoundly impaired volitional saccades after aortic surgery is a distinctive syndrome, but its pathophysiology is unclear. Studies of neurologic damage in animals and patients undergoing similar surgical procedures provide conflicting data. However, knowledge about the complex neural pathways generating saccades from animal and human studies, and detailed clinical observations, as in the patients described here, can help to determine the location of lesions. Based on the 3 cases reported here, we propose that this syndrome might be due to damage to excitatory burst and/or om...
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Yee RD, Purvin VA Tags: Trans Am Ophthalmol Soc Source Type: journals

Occurrence of giant cell arteritis...Suddenly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Partial activation of vascular dendritic cells is typically seen in patients with polymyalgia rheumatica in whom no inflammatory infiltrates are seen on histomorphologic examination. Dendritic cells become activated at an early stage of arteritis, beginning the pathologically evident arteritis, and are fully matured in microscopically florid arteritis. PMID: 18427603 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Younge BR, Weyand CM, Goronzy JJ Tags: Trans Am Ophthalmol Soc Source Type: journals

Computer-based primary visual cortex training for treatment of low myopia and early presbyopia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Results to date suggest that the NeuroVision technology is effective in improving UCVA and unaided CSF in low myopia and early presbyopia. PMID: 18427602 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Durrie D, McMinn PS Tags: Trans Am Ophthalmol Soc Source Type: journals

Machine learning classifiers detect subtle field defects in eyes of hiv individuals.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study has confirmed that low-CD4 eyes have visual field defects and retinal damage. Ranking located important field locations superiorly near the blind spot, implying damage to the retina inferiorly near the optic disc. Though most fields appear normal in high-CD4 eyes, SVM and RVM were sufficiently sensitive to distinguish these eyes from normal eyes with SAP. The location of these defects is not yet defined. These results also validate the use of sensitive MLC techniques to uncover test differences not discernible by human experts. PMID: 18427600 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Kozak I, Sample PA, Hao J, Freeman WR, Weinreb RN, Lee TW, Goldbaum MH Tags: Trans Am Ophthalmol Soc Source Type: journals

An age-based method for planning sclerotomy placement during pediatric vitrectomy: a 12-year experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The age-based method for sclerotomy placement may provide a useful guideline for vitrectomy in children with normal ocular growth and development. PMID: 18427597 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Lemley CA, Han DP Tags: Trans Am Ophthalmol Soc Source Type: journals

Primary acquired melanosis of the conjunctiva: experience with 311 eyes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: PAM without atypia or with mild atypia shows 0% progression into melanoma, whereas PAM with severe atypia shows progression into melanoma in 13%. The greater the extent of PAM in clock hours, the greater the risk for transformation into melanoma. PMID: 18427595 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Shields JA, Shields CL, Mashayekhi A, Marr BP, Benavides R, Thangappan A, Phan L, Eagle RC Tags: Trans Am Ophthalmol Soc Source Type: journals

An alternative hypothesis for observed mortality rates due to metastasis after treatment of choroidal melanomas of different sizes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The better prognosis of patients with smaller choroidal melanomas is likely to be attributable to a lower probability of cytogenetic abnormalities indicative of metastatic capability among smaller tumors and not to effectiveness of treatment at preventing metastasis. PMID: 18427594 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Augsburger JJ, Corrêa ZM, Trichopoulos N Tags: Trans Am Ophthalmol Soc Source Type: journals

Custom optimization of intraocular lens asphericity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The amount of ocular SA producing best image quality varied widely among subjects and could be predicted based on corneal HOAs. Selection of an aspheric IOL should be customized according to the full spectrum of corneal HOAs and not 4th-order SA alone. PMID: 18427592 [PubMed - in process]
Source: Transactions of the American Ophthalmological Society - January 1, 2007 Category: Opthalmology Authors: Koch DD, Wang L Tags: Trans Am Ophthalmol Soc Source Type: journals

Gene transfer for the treatment of neovascular ocular disease (an American Ophthalmological Society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lentiviral vectors are a viable means to deliver angiostatic genes to tissues of the eye. Some angiostatic genes appear to have a stronger and longer-lasting effect than others in modulating the angiogenic pathway. PMID: 17471360 [PubMed - indexed for MEDLINE]
Source: Transactions of the American Ophthalmological Society - January 1, 2006 Category: Opthalmology Authors: Stout JT Tags: Trans Am Ophthalmol Soc Source Type: journals

Effect of rapamycin on the fate of P23H opsin associated with retinitis pigmentosa (an American Ophthalmological Society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggest that rapamycin induces the loss of P23H opsin and DeltaF508 CFTR from the cell under the experimental conditions described. Concomitantly, there is increased expression and colocalization of autophagy marker proteins with P23H opsin. Immunogold electron microscopic studies demonstrate autophagic vacuoles clustered in physical proximity to the aggregates of P23H opsin, suggesting that some of the loss of P23H is related to the induction of autophagy. Thus, rapamycin may be useful to clear misfolded proteins associated with retinal degeneration. PMID: 17471359 [PubMed - indexed for MEDLINE]
Source: Transactions of the American Ophthalmological Society - January 1, 2006 Category: Opthalmology Authors: Kaushal S Tags: Trans Am Ophthalmol Soc Source Type: journals

Long-term visual outcomes in extremely low-birth-weight children (an American Ophthalmological Society thesis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Long-term visual development in extremely low-birth-weight infants is problematic and associated with a high risk of subnormal acuity. Early acuity testing is useful in identifying children at greatest risk for long-term visual abnormalities. Gestational age at birth of </= 28 weeks was associated with a higher risk of an abnormal long-term outcome. PMID: 17471358 [PubMed - indexed for MEDLINE]
Source: Transactions of the American Ophthalmological Society - January 1, 2006 Category: Opthalmology Authors: Spencer R Tags: Trans Am Ophthalmol Soc Source Type: journals