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1273 records returned

The aging population poses a global challenge for blood services.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A large part of the variation in RBC use per capita can be explained by the age distribution of the different populations and not by the different national and regional treatment policies and protocols used. If current efforts are not enough to serve the changing population demographic and if increasing demands for blood products cannot be met, there is need to consider unprecedented measures such as reversing certain donor deferrals or even exporting blood from country to country. PMID: 19912582 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Ali A, Auvinen MK, Rautonen J Tags: Transfusion Source Type: journals

The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Variable volumes of UC-WB can be stored for 35 days without prestorage processing and further work into its suitability for transfusion to children is justified. The quality of conventional AD-WB is a concern and needs further evaluation. PMID: 19912583 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Hassall O, Maitland K, Fegan G, Thitiri J, Pole L, Mwakesi R, Denje D, Wambua K, Mandaliya K, Bates I Tags: Transfusion Source Type: journals

Declining hepatitis C virus (HCV) prevalence in pregnant women: impact of anti-HCV screening of donated blood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Anti-HCV screening of donated blood and hygienic improvements have markedly decreased HCV infection of pregnant women with a transfusion history; however, 70% of anti-HCV-reactive women were deemed to be infected via routes other than transfusion. PMID: 19912584 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Ohto H, Ishii T, Kitazawa J, Sugiyama S, Ujiie N, Fujimori K, Ariga H, Satoh T, Nollet KE, Okamoto H, Hoshi T Tags: Transfusion Source Type: journals

Direct assessment of cytomegalovirus transfusion-transmitted risks after universal leukoreduction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Among all 46 baseline seronegative recipients and 1316 evaluable transfusions, the calculated overall CMV-TTD risk was up to 6.5% (95% confidence interval [CI], 1.0%-18.0%) in terms of TRs and up to 0.23% (95% CI, 0.06%-0.62%) in terms of non-CMV-screened leukoreduced cellular products. In summary, after universal leukoreduction, CMV-TTD, while uncommon, may still occur. PMID: 19912585 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Wu Y, Zou S, Cable R, Dorsey K, Tang Y, Hapip CA, Melmed R, Trouern-Trend J, Wang JH, Champion M, Fang C, Dodd R Tags: Transfusion Source Type: journals

Long-term storage of peripheral blood stem cells frozen and stored with a conventional liquid nitrogen technique compared with cells frozen and stored in a mechanical freezer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In vitro measurements indicate that PBSCs can be successfully frozen and stored using a combination of DMSO and HES providing smaller amounts of DMSO and allowing simplified freezing and storage conditions. PMID: 19912586 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: McCullough J, Haley R, Clay M, Hubel A, Lindgren B, Moroff G Tags: Transfusion Source Type: journals

Novel antibody screening cells, MUT+Mur kodecytes, created by attaching peptides onto red blood cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study used selected MUT and Mur peptides and KODE cell surface engineering technology to create MUT+Mur kodecytes suitable for the detection and identification of RBC antibodies in human serum or plasma. This technology has the potential to create a large range of specialized RBCs for antibody screening and identification. PMID: 19912581 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 11, 2009 Category: Hematology Authors: Heathcote D, Carroll T, Wang JJ, Flower R, Rodionov I, Tuzikov A, Bovin N, Henry S Tags: Transfusion Source Type: journals

Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These findings demonstrate that HOD murine RBCs become more immunogenic with storage and generate the rationale for clinical trials to test if the same phenomenon is observed in humans. Length of storage of RBCs may represent a previously unappreciated variable in whether or not a transfusion recipient becomes alloimmunized. PMID: 19906034 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Hendrickson JE, Hod EA, Spitalnik SL, Hillyer CD, Zimring JC Tags: Transfusion Source Type: journals

sHLA-I contaminating molecules as novel mechanism of ex vivo/in vitro transcriptional and posttranscriptional modulation of transforming growth factor-beta in CD8+ T lymphocytes and neutrophils after intravenous immunoglobulin treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: On the whole, these data lead us to speculate that the ability of IVIG administration to modulate TGF-beta(1) might be related to the immunomodulatory activities of sHLA-I and sFasL molecules on activated CD8+ T lymphocytes and neutrophils. PMID: 19906035 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Ghio M, Contini P, Negrini S, Proietti M, Gonella R, Ubezio G, Ottonello L, Indiveri F Tags: Transfusion Source Type: journals

Streamlining ABO antibody titrations for monitoring ABO-incompatible kidney transplants.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The revised TT and IgG gel titers are comparable to the CTT AHG titers. The IgG gel method offers the best titer turnaround time, eliminating 45 minutes of incubation time alone. Implementation of this technique would benefit ABO INKT patients by providing titer results in a more timely manner. PMID: 19906036 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Shirey RS, Cai W, Montgomery RA, Chhibber V, Ness PM, King KE Tags: Transfusion Source Type: journals

Improvement of an ultrasensitive human immunodeficiency virus Type 1 real-time reverse transcriptase-polymerase chain reaction targeting the long terminal repeat region.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Surveillance of HIV-1 genetic diversity is essentially required to continually evaluate its impact on performance of diagnostic and patient monitoring assays. PMID: 19906037 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Edelmann A, Kalus U, Oltmann A, Stein A, Unbehaun A, Drosten C, Krüger DH, Hofmann J Tags: Transfusion Source Type: journals

Testing blood donors for Chagas disease in the Paris area, France: first results after 18 months of screening.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The efficiency of blood donor screening programs could be improved by screening only blood donors who were born in LA or who have traveled in LA for extended periods, using a single enzyme immunoassay. PMID: 19906038 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: El Ghouzzi MH, Boiret E, Wind F, Brochard C, Fittere S, Paris L, Mazier D, Sansonetti N, Bierling P Tags: Transfusion Source Type: journals

Reports on clinical transfusion medicine in the early days of TRANSFUSION.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19906039 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Aubuchon JP, Dzik WS Tags: Transfusion Source Type: journals

Blood groups: the past 50 years.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since the first issue of TRANSFUSION in 1961, there has been a tremendous expansion in not only the number of blood group antigens identified but also in our knowledge of their biochemical basis, function, and more recently, associated DNA changes. As certain techniques became available, our ability to discover and elucidate blood group antigens and appreciate their contribution to biology became possible. In particular, Western blotting, monoclonal antibodies, cloning, and polymerase chain reaction-based assays have led to an explosion of our knowledge base. The study of blood groups has had a significant effect on hu...
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Daniels G, Reid ME Tags: Transfusion Source Type: journals

A fatal case of transfusion-transmitted babesiosis in the State of Delaware.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We believe that this is the first reported case of transfusion-transmitted babesiosis in Delaware, a nonendemic state. Our case illustrates that clinicians should consider babesiosis in the differential diagnosis of immunocompromised patients who have fever and recent transfusion history, even in areas where babesiosis is not endemic. It also demonstrates the need for better preventive strategies including more sensitive, specific, and rapid blood donor screening tests to prevent transfusion-transmitted babesiosis. PMID: 19906041 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Zhao Y, Love KR, Hall SW, Beardell FV Tags: Transfusion Source Type: journals

Compensated variability in the expression of globin-related genes in erythroblasts generated ex vivo from different donors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Ex vivo expanded erythroblasts from normal donors express modestly imbalanced levels of alpha-globin and gamma + beta-globin fully compensated by AHSP expression, likely ensuring normal function and survival. PMID: 19891622 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 4, 2009 Category: Hematology Authors: Varricchio L, Fabucci ME, Alfani E, Godbold J, Migliaccio AR Tags: Transfusion Source Type: journals

Hemolytic disease of the fetus/newborn: reflections on articles from TRANSFUSION Volume 1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19874560 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 23, 2009 Category: Hematology Authors: Strauss RG Tags: Transfusion Source Type: journals

Periods without agitation diminish platelet mitochondrial function during storage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: PLTs, if stored without agitation, produce a lesion that leads PLTs to apoptosis. The severity of the lesion depends on the length of the period without agitation. Prolonged periods without agitation induce formation of superoxides and depolarization of MMP along with a presentation of apoptotic markers. PMID: 19874561 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 23, 2009 Category: Hematology Authors: Skripchenko A, Myrup A, Thompson-Montgomery D, Awatefe H, Moroff G, Wagner SJ Tags: Transfusion Source Type: journals

Red blood cell aging markers during storage in citrate-phosphate-dextrose-saline-adenine-glucose-mannitol.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We provide circumstantial evidence for a lower protein oxidative damage in CPD-SAGM-stored RBCs compared to the CPDA-stored cells. The different expression patterns of the senescence markers in the RBCs seem to be accordingly related to the oxidative stress management of the cells. We suggest that the storage of RBCs in CPD-SAGM might be more alike the in vivo RBC aging process, compared to storage in CPDA, since it is characterized by a slower stimulation of the recognition signaling pathways that are already known to trigger the erythrophagocytosis of senescent RBCs. PMID: 19874562 [PubMed - as supplied ...
Source: Transfusion - October 23, 2009 Category: Hematology Authors: Antonelou MH, Kriebardis AG, Stamoulis KE, Economou-Petersen E, Margaritis LH, Papassideri IS Tags: Transfusion Source Type: journals

Recipient-derived HPA-1a antibodies: a cause of prolonged thrombocytopenia after unrelated donor stem cell transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: HPA-1a antibodies were associated with protracted PLT-transfusion dependence and significant hemorrhagic complications. Appropriate and timely laboratory investigation for HPA-specific antibodiesfollowed by transfusion support with HPA-selected PLTs provided the cornerstone of the hemostatic management in these cases. PMID: 19874563 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 23, 2009 Category: Hematology Authors: Lucas G, Culliford S, Green F, Sidra G, Calvert A, Green A, Harrison P, Harvey J, Allen D, Smillie D, Masurekar A, Marks D, Russell N, Massey E Tags: Transfusion Source Type: journals

Immune hemolytic anemia due to cimetidine: the first example of a cimetidine antibody.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This is the first reported case of IHA due to a cimetidine antibody where a drug-dependent antibody was demonstrated. The patient had IHA after receiving cimetidine on two separate occasions. PMID: 19874564 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 23, 2009 Category: Hematology Authors: Arndt PA, Garratty G, Brasfield FM, Vemuri SL, Asuncion DJ Tags: Transfusion Source Type: journals

Life-threatening hemolytic anemia due to an autoanti-Pr cold agglutinin: evidence that glycophorin A antibodies may induce lipid bilayer exposure and cation permeability independent of agglutination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The anti-Pr CA and rabbit anti-human GPA increased exposure of PE and increased membrane Ca(2+) permeability that may have caused hemolysis. The difference in the responses to these antibodies to enzyme treatment of RBCs suggests that they react with different epitopes on GPA. PMID: 19843291 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 18, 2009 Category: Hematology Authors: Brain M, Ruether B, Valentine K, Brown C, Ter Keurs H Tags: Transfusion Source Type: journals

Relative safety of first-time volunteer and replacement donors in West Africa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In Kumasi, Ghana, viral safety of replacement and first-time volunteer donors was similar, constituting a single population of donors. Safety increment is provided by repeat donation applicable to either group, through different approaches. A blood unit from replacement donor costs half or less than that from a volunteer donor; similar studies conducted elsewhere in sub-Saharan Africa may lead to changes in current strategies. PMID: 19843284 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Allain JP, Sarkodie F, Asenso-Mensah K, Owusu-Ofori S Tags: Transfusion Source Type: journals

Moderate and severe adverse events associated with apheresis donations: incidences and risk factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Apheresis collections performed by TA instruments are safe with a low incidence of significant AEs. Various types of AEs have different predisposing factors. Apheresis may be a safer option for donors with risk factors for PS reactions associated with whole blood collections, such as younger age, female sex, and small TBV. PMID: 19843285 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Yuan S, Ziman A, Smeltzer B, Lu Q, Goldfinger D Tags: Transfusion Source Type: journals

Scrub typhus induced by peripheral blood stem cell transplantation in the immunocompromised patient: diagnostic usefulness of nested polymerase chain reaction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scrub typhus (Orientia tsutsugamushi) is a Gram-negative rickettsial disease in parts of Asia, transmitted from wild rodents to human by mites. This is a case report of scrub typhus contraction in an acute leukemia patient by transfusion of peripheral blood stem cells collected during the incubation period. Although human-to-human transmission of scrub typhus by needle-stick injury or transplacental transmission has previously been reported, this is the first case confirmed by polymerase chain reaction (PCR) and DNA sequencing. This type of incident shows the need to heighten awareness of the threat of rickettsial agen...
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Kang SJ, Park KH, Jung SI, Jang HC, Ji SY, Ahn JS, Kim HJ, Shin JH, Kim DM Tags: Transfusion Source Type: journals

Plasma and cryoprecipitate manufactured from whole blood held overnight at room temperature meet quality standards.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Plasma and cryoprecipitate products, prepared using methods in which the plasma is frozen close to 24 hours after collection, meet current quality standards. The longer WB storage time has been implemented into general use in Canada. PMID: 19843287 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Serrano K, Scammell K, Weiss S, Culibrk B, Levin E, Gyöngyössy-Issa M, Devine DV Tags: Transfusion Source Type: journals

Immunomonitoring of graft-versus-host minor histocompatibility antigen correlates with graft-versus-host disease and absence of relapse after graft.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results provide a robust method to monitor mH antigen graft-versus-host reaction and suggest that current identified mH have predictive value on GVHD and GVL. PMID: 19843288 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Laurin D, Hannani D, Pernollet M, Moine A, Plumas J, Bensa JC, Cahn JY, Garban F Tags: Transfusion Source Type: journals

Increase in CD230 (cellular prion protein) fluorescence on blood lymphocytes in bovine spongiform encephalopathy-infected nonhuman primates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Blood lymphocytes from asymptomatically infected as well as diseased macaques were characterized by increased CD230 fluorescence, and phosphatidylinositol-phospholipase C-resistant PrP molecules contributed at least partially to this increase. Conformational changes within PrP(c) molecules may be the underlying mechanism for the increased PrP(c) fluorescence. This cell-associated phenomenon contributed at least partially to an increase in soluble plasma-derived PrP(c) levels. It is not yet known whether these changes reflect infectivity. PMID: 19843289 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Holznagel E, Yutzy B, Schulz-Schaeffer W, Hanschman KM, Stuke A, Hahmann U, Törner M, Coulibaly C, Hoffmann A, Hunsmann G, Löwer J Tags: Transfusion Source Type: journals

The risk of transfusion-transmitted infections in sub-Saharan Africa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study is the first to systematically quantify the risks of transfusion-transmitted infections across sub-Saharan Africa. Although the results are limited by the quality and quantity of available data, these may be the most reliable estimates at this time. PMID: 19843290 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 14, 2009 Category: Hematology Authors: Jayaraman S, Chalabi Z, Perel P, Guerreiro C, Roberts I Tags: Transfusion Source Type: journals

CD34+ cells obtained from "good mobilizers" are more activated and exhibit lower ex vivo expansion efficiency than their counterparts from "poor mobilizers"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A good response to G-CSF mobilization treatment is associated with a higher degree of proliferative and metabolic activation of mobilized CD34+ cells with a decrease in their expansion capacity. PMID: 19821946 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 11, 2009 Category: Hematology Authors: Ivanovic Z, Kovacevic-Filipovic M, Jeanne M, Ardilouze L, Bertot A, Szyporta M, Hermitte F, Lafarge X, Duchez P, Vlaski M, Milpied N, Pavlovic M, Praloran V, Boiron JM Tags: Transfusion Source Type: journals

Platelet gel for treatment of mucocutaneous lesions related to graft-versus-host disease after allogeneic hematopoietic stem cell transplant.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These preliminary data show that the PLT gel may be used as a safe and effective tool in the management of mucosal skin lesions related to the GVHD. PMID: 19821947 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 9, 2009 Category: Hematology Authors: Picardi A, Lanti A, Cudillo L, Cerretti R, Dentamaro T, De Angelis G, Ferraro A, Di Veroli A, Adorno G, Arcese W Tags: Transfusion Source Type: journals

New low-frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: NATP in the three cases was caused by maternal immunization against previously unreported, low-frequency GP polymorphisms. Maternal immunization against low-frequency PLT-specific alloantigens should be considered in cases of apparent NATP not resolved by conventional serologic and molecular testing. PMID: 19821948 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 9, 2009 Category: Hematology Authors: Peterson JA, Gitter ML, Kanack A, Curtis B, McFarland J, Bougie D, Aster R Tags: Transfusion Source Type: journals

Red blood cell alloimmunization in sickle cell disease patients in Uganda.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The rate of RBC alloimmunization in Ugandan SCD patients was 6.1%. The homogeneity between donors and SCD patients plus the low transfusion load may explain this immunization frequency. Nevertheless, our study confirms the significance of RBC alloimmunization as a complication in Ugandan SCD patients. Therefore, there is need to improve immunohematologic testing in Uganda so that RBC alloimmunization and its consequences may be prevented. PMID: 19821949 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 9, 2009 Category: Hematology Authors: Natukunda B, Schonewille H, Ndugwa C, Brand A Tags: Transfusion Source Type: journals

Skin disinfection methods: prospective evaluation and postimplementation results.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this study, isopropyl alcohol and chlorhexidine disinfectants were more efficacious than isopropyl alcohol and iodine. There was no difference in efficacy between one-step and two-step procedures or between methods of application. A one-step chlorhexidine and isopropyl alcohol kit has been successfully implemented at CBS. PMID: 19821950 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 9, 2009 Category: Hematology Authors: Ramirez-Arcos S, Goldman M Tags: Transfusion Source Type: journals

Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through 2007.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Foci of statistically higher B. microti seroprevalence among blood donors were observed; however, B. microti transfusion transmission risk exists for blood collected throughout Connecticut and portions of Massachusetts. Similarly, a seasonal peak was identified; nevertheless, seropositive donations were found year-round. Thus, geographic and/or seasonal exclusion methods are insufficient to fully safeguard the blood supply from Babesia transmission. Steps should be taken to reduce risk of transfusion-transmitted B. microti, perhaps through implementation of year-round, regional testing. PMID: 19821951 [Pub...
Source: Transfusion - October 9, 2009 Category: Hematology Authors: Johnson ST, Cable RG, Tonnetti L, Spencer B, Rios J, Leiby DA Tags: Transfusion Source Type: journals

Transfusion-transmitted babesiosis in the United States: summary of a workshop.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussions were also held on the biology, pathogenesis, and epidemiology of Babesia species. In this article, we summarize the scientific presentations and panel discussions that took place during the workshop. PMID: 19821952 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 9, 2009 Category: Hematology Authors: Gubernot DM, Nakhasi HL, Mied PA, Asher DM, Epstein JS, Kumar S Tags: Transfusion Source Type: journals

The practice of reporting transfusion-related acute lung injury: a national survey among clinical and preclinical disciplines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A pretransfusion inflammatory condition is a reason to withhold from reporting of a suspected TRALI case. Disciplines involved in managing TRALI differ in decision-making of reporting TRALI, which may contribute to variance in incidence. PMID: 19804567 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Vlaar AP, Wortel K, Binnekade JM, van Oers MH, Beckers E, Gajic O, Schultz MJ, Juffermans NP Tags: Transfusion Source Type: journals

Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In the civilian setting, plasma, PLT, and cryoprecipitate products significantly increased 30-day survival in trauma patients. Future prospective randomized clinical trials are required to determine the optimal transfusion ratios. PMID: 19804568 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Shaz BH, Dente CJ, Nicholas J, Macleod JB, Young AN, Easley K, Ling Q, Harris RS, Hillyer CD Tags: Transfusion Source Type: journals

Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Prospective triage and evidence-based transfusion practice education reduced unnecessary plasma and PLT transfusions and health care costs. PMID: 19804569 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Sarode R, Refaai MA, Matevosyan K, Burner JD, Hampton S, Rutherford C Tags: Transfusion Source Type: journals

Improved plasma removal efficiency for therapeutic plasma exchange using a new apheresis platform.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The SPO has improved performance characteristics over the CSP. Based on our results, the SPO is acceptable for use in therapeutic plasma exchange programs. PMID: 19804570 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Tormey CA, Peddinghaus ME, Erickson M, King KE, Cushing MM, Bill J, Goodrich T, Snyder EL Tags: Transfusion Source Type: journals

A single assay for multiple storage-sensitive red blood cell characteristics by means of infrared spectroscopy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: IR spectroscopy is a promising technique to follow structural and metabolic changes in RBCs during storage under blood bank conditions. Several variables can be determined rapidly in a single measurement. PMID: 19804571 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Pistorius AM, Luten M, Bosman GJ, Degrip WJ Tags: Transfusion Source Type: journals

Many genetically defined ABO subgroups exhibit characteristic flow cytometric patterns.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Genetically defined ABO subgroups and other anomalous phenotypes displayed flow cytometric profiles that may contribute valuable information to the investigation of ABO discrepancies. We conclude that the presented assay may complement traditional serology and genetic analysis in the reference laboratory setting. PMID: 19804572 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Hult AK, Olsson ML Tags: Transfusion Source Type: journals

Delayed adverse reactions to blood donation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Low EBV, youth, and first-time donor status are major risk factors for IRs and DRs. Women are more likely than men to report DRs. Delayed and off-site reactions lead to potentially preventable morbidity. Understanding the physiologic basis of DRs may lead to the development of appropriate interventions to reduce their likelihood. PMID: 19804573 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Kamel H, Tomasulo P, Bravo M, Wiltbank T, Cusick R, James RC, Custer B Tags: Transfusion Source Type: journals

Intraoperatively salvaged red blood cells contain nearly no functionally active platelets, but exhibit formation of microparticles: results of a pilot study in orthopedic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Only few free and thus active PLTs are detectable in processed RBCs. It seems very unlikely that these few PLTs can improve clot strength. Nevertheless, the impact of the detected MPs on thrombin generation needs to be clarified in further studies. PMID: 19804574 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - October 4, 2009 Category: Hematology Authors: Oswald E, Streif W, Hermann M, Hengster P, Mittermayr M, Innerhofer P Tags: Transfusion Source Type: journals

Prevalence of and risk factors for hepatitis B and C infection among Mongolian blood donors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This sentinel study of hepatitis prevalence among Mongolian blood donors sheds considerable light on the epidemiology of hepatitis virus infection as well as the sociodemographic and behavioral risk factors associated with infection. Young age (HBsAg) and pregnancy (anti-HCV) were significant risk factors for hepatitis virus infection, indicating that improvements in education, vaccination rates, and general infection control procedures in health care institutions may reduce behavioral and nosocomial transmission. PMID: 19788639 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 24, 2009 Category: Hematology Authors: Tserenpuntsag B, Nelson K, Lamjav O, Triner W, Smith P, Kacica M, McNutt LA Tags: Transfusion Source Type: journals

Rubella vaccination and transitory false-positive test results for human immunodeficiency virus Type 1 in blood donors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19788507 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 23, 2009 Category: Hematology Authors: Araujo PR Tags: Transfusion Source Type: journals

Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta-thalassemia: challenges in treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Treatment of DHTR remains challenging. The role of immunosuppressive medication such as azathioprine, cyclosporin A, and rituximab remains to be seen. Splenectomy may be helpful. Mainstay is to minimize RBC transfusions as much as possible. PMID: 19788508 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 23, 2009 Category: Hematology Authors: Hannema SE, Brand A, van Meurs A, Smiers FJ Tags: Transfusion Source Type: journals

Pressure-aided transfusion of platelets: does it affect the platelets?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this study, use of a pressure inducer decreased the transfusion time of in vitro PLT transfusion by approximately 50%. No or only minor and inconsistent changes of the PLT number and function were observed. Consequently, this study indicates that pressure infusers could be used for transfusion of PLTs if clinically indicated, that is, in massively bleeding patients. However, in vivo studies to assess the safety and utility of pressure-aided PLT transfusion are warranted. PMID: 19788509 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 23, 2009 Category: Hematology Authors: Fischer-Nielsen A, Stissing T, Maansson C, Joergensen BG Tags: Transfusion Source Type: journals

Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The results suggest that donor iNKT cells could alleviate GVHD symptoms and prolong survival after MHC-mismatched allogeneic BMT, which may be associated with the maintenance in IL-4 levels. These findings indicate that the therapy based on iNKT cells from MHC-mismatched donors has great potential in protection against GVHD after allogeneic hematopoietic stem cell transplantation. PMID: 19788510 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 23, 2009 Category: Hematology Authors: Yang J, Gao L, Liu Y, Ren Y, Xie R, Fan H, Qian K Tags: Transfusion Source Type: journals

Pharmacokinetic analysis of human plasma-derived pasteurized C1-inhibitor concentrate in adults and children with hereditary angioedema: a prospective study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: pC1-INH concentrate has a long median terminal elimination half-life and rapidly reaches maximum plasma concentrations. This rapid onset of clinical efficacy is essential in patients suffering from HAE. PMID: 19788511 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 23, 2009 Category: Hematology Authors: Martinez-Saguer I, Rusicke E, Aygören-Pürsün E, von Hentig N, Klingebiel T, Kreuz W Tags: Transfusion Source Type: journals

International variation in volunteer whole blood donor eligibility criteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: International volunteer whole blood donor eligibility criteria demonstrate marked variation. These differences likely cause international variation in the prevalence of adverse donor reactions and iron deficiency anemia. The reasons underlying these dissimilarities are unclear, but may include varying cultural influences and average donor body habitus. PMID: 19788512 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 23, 2009 Category: Hematology Authors: Karp JK, King KE Tags: Transfusion Source Type: journals