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HIV, HCV, HBV and syphilis rate of positive donations among blood donations in Mali: Lower rates among volunteer blood donors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Good data on background seroprevalence of major transfusion transmitted infections is lacking in Mali. We gathered data on the rate of positive donations of human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV) and syphilis among blood donations in Mali for calendar year 2007. Donations with repeatedly reactive results on screening enzyme immunoassay (EIA) were considered to be seropositive. Rate of positive donations per blood unit collected was 2.6% for HIV, 3.3% for HCV, 13.9% for hepatitis B surface antigen (HBsAg) and 0.3% for syphilis. For HIV, HBsAg and syphilis, rate of positive d...
Source: Transfusion Clinique et Biologique - November 4, 2009 Category: Hematology Authors: Diarra A, Kouriba B, Baby M, Murphy E, Lefrere JJ Tags: Transfus Clin Biol Source Type: journals

[Situation and perspectives of blood transfusion in Togo.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the successive stages of the reorganization of the blood transfusion sector in Togo. The starting point was the elaboration of the national policy of blood transfusion, then the adoption of a decree organizing the sector as well the various decree of application, particularly that related to transfusion good practices. The current policy recommends two poles of qualification of the blood ant its components and the creation of six stations of collection and distribution attached to these poles. The reorganization started with the rehabilitation of the National Blood Transfusion Centre (CNTS) in Lomé. If the p...
Source: Transfusion Clinique et Biologique - November 4, 2009 Category: Hematology Authors: Ségbéna AY, Fétéké L, Bikandou B, Awitala EJ, Koura AG Tags: Transfus Clin Biol Source Type: journals

[Contribution of electronic data interchange to haemovigilance in a hospital - Experience in the University Hospital of Reims.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although the new process was supposed to be more efficient and easier for the user, the global result on traceability by users is negative after 18months. PMID: 19880338 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - October 30, 2009 Category: Hematology Authors: Lartigue B, Coffin S, Pottier M Tags: Transfus Clin Biol Source Type: journals

[Genetic diversity of human erythroviruses. Consequences on infectious safety of plasma derivatives.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The B19 Parvovirus (B19V) has for a long time been considered as the unique human virus belonging to the genus Erythrovirus. The genetic diversity of B19V isolates has been shown to be very low. The isolation of a variant (V9 strain), with a sequence markedly distinct from that of B19V which led to attributing this classification to this family of viruses. Phylogenetic analysis of sequences of V9-related isolates indicates an organization into three well-individualized genotypes. The B19V infection can be transmitted by transfusion. In immunocompetent recipients, B19V exposure by transfusion is most often inconsequenti...
Source: Transfusion Clinique et Biologique - October 30, 2009 Category: Hematology Authors: Servant-Delmas A, Mercier M, Laperche S, Lefrère JJ Tags: Transfus Clin Biol Source Type: journals

[Kidney transplantation in patient with haemophilia A.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 37-year-old patient with moderate haemophilia A and end-stage renal disease underwent kidney transplantation in the University Hospital Ibn Rochd of Casablanca (Morocco). He received factor VIII replacement therapy perioperatively and until the 21st day postoperation. So, the activity rates of Factor VIII was higher than or equal to 80 % in the day of intervention and two to three days later, then between 30 and 60 % until healing. The evolution of the patient to 28 months post-transplantation is marked by a good renal function without episode of rejection or bleeding complications. The heavy surgical interventions a...
Source: Transfusion Clinique et Biologique - October 29, 2009 Category: Hematology Authors: El Bakkouri J, Mamdouh A, Faez S, Medkouri G, Ramdani B, Benchemsi N Tags: Transfus Clin Biol Source Type: journals

[The transfusion center, the blood donor and the given blood in francophone African countries.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In subsaharan Africa, knowledge of the organization and methods of transfusion centers, as well as blood donor characteristics, is essential in choosing strategies to improve transfusion practices and the security of blood products on this Continent. The present study was based on a analysis led in partnership with the transfusion of seven francophone African countries (Burkina-Faso, Cameroon, Congo, Ivory Cost, Mali, Niger, and Rwanda). The results showed that withstanding significant progress has been realized in the organization and safety, but much remains to be undertaken over the years to come in order to improve...
Source: Transfusion Clinique et Biologique - September 24, 2009 Category: Hematology Authors: Tayou Tagny C, Diarra A, Yahaya R, Hakizimana M, Nguessan A, Mbensa G, Nébié Y, Dahourou H, Tapko JB, Shiboski C, Murphy E, Lefrère JJ Tags: Transfus Clin Biol Source Type: journals

[How to manage analysis and feedback of adverse events in transfusion.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analysing adverse events is part of the medical practice in so far as the part it plays is outstanding in terms of feedback and improved healthcare safety. The integrated implementation of this practice is based on a four-dimensional system: strategic (corporate policies), cultural (safety-oriented cultural mindset), structural (dedicated organization and resources) and technical (methodologies and utilities). Two case studies illustrate the sequencing process from selecting the to-be-analyzed event down to figuring out the appropriate action plan. Beyond the visible and obvious origin, thanks to the implemented method...
Source: Transfusion Clinique et Biologique - September 23, 2009 Category: Hematology Authors: Roussel P, Moll MC, Lassale B, Ragni J Tags: Transfus Clin Biol Source Type: journals

RBC alloimmunization is an important complication of FFP transfusion: A case report of immune anti-D induced by apheresis fresh frozen plasma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a female group A, D- patient with cerebrovascular disease who was induced to develop IgG immune anti-D which can be detected on the 15th day of hospitalization after the relatively regular time interval of transfusion of 1800ml apheresis FFP. Therefore, in making clinical decisions to transfuse FFP or apheresis FFP, the best choice is considered as the same or compatibility with RhD group, in case Rh immunization can be induced and trigger some potential serious problems in future emergent transfusion or pregnancy, especially in high incidence of D antigen countries. PMID: 19748813 [PubMed - as supplied by pu...
Source: Transfusion Clinique et Biologique - September 10, 2009 Category: Hematology Authors: Liu F, Zhou FY, Hu LH Tags: Transfus Clin Biol Source Type: journals

[The red blood cell antigen terminologies.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since the discovery of blood groups in humans, several hundred new red blood cell antigens have been identified. Multiple terminology modes have been used to denote each new antigen identified, but without any consistent rules, nor international consensus. This was largely due to the many discoverers of these antigens, using either letters of the alphabet, numbers, part of the patient or donor's name, place of discovery or animal names. Besides, alternative terminologies for the Rh system were implemented in the middle of the twentieth century (Rosenfield, Fisher-Race, Wiener). The International Society of Blood Transf...
Source: Transfusion Clinique et Biologique - August 26, 2009 Category: Hematology Authors: Peyrard T, Rouger P Tags: Transfus Clin Biol Source Type: journals

[Screening of syphilis in the Subsaharan African blood donor: Which strategy?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a context of high prevalence of syphilis in blood donor and of resources-limited settings, this review aims to describe biological elements which are available for the screening of the disease and the essentials considerations which participate to choose a screening test in subsaharan Africa. Treponemics, non treponemics, immunochromatographics or nucleic, the type of the chosen screening test must contribute to the blood transfusion safety as well as be affordable. PMID: 19695921 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - August 17, 2009 Category: Hematology Authors: Tagny CT Tags: Transfus Clin Biol Source Type: journals

[Prevention of transfusion transmitted malaria in endemic area.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Plasmodium represents the third risk of blood transmitted infectious agents after hepatitis B virus, syphilis, and before HCV and HIV in Senegal. The medical questionnaire is not useful enough for asymptomatic carriers deferral, and we propose to introduce Plasmodium screening. The screening for Plasmodium pLDH by Elisa technique seems to be the best tool in endemic area and the strategy of systematic screening is the most suited in terms of blood transfusion safety. PMID: 19665412 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - August 5, 2009 Category: Hematology Authors: Diop S, Ndiaye M, Seck M, Chevalier B, Jambou R, Sarr A, Dièye TN, Touré AO, Thiam D, Diakhaté L Tags: Transfus Clin Biol Source Type: journals

The role and impact of the transfusion medicine consultation service in the management of patients in the hematopoietic transplant service: A retrospective analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Use of these safety tools has improved the safety culture regarding transfusion of blood components in hematopoietic transplant recipients at our institution. PMID: 19665413 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - August 5, 2009 Category: Hematology Authors: Narvios A, Rodriguez-Jackson L, Reddy V, Lichtiger B Tags: Transfus Clin Biol Source Type: journals

[Teaching transfusion medicine research in the francophone world.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A two-week, French language, clinical research course in transfusion medicine has recently been created at the Pasteur Institute in Paris under the joint leadership of faculty members from the University of California San Francisco (UCSF), the Blood Systems Research Institute (BSRI) and the National Institute of Transfusion of Paris. The goal is to train transfusion professionals from the developing world to conduct clinical research that will contribute to improving the quality of care and safety in transfusion practices in their respective countries. The course provides training on clinical and epidemiological resear...
Source: Transfusion Clinique et Biologique - July 26, 2009 Category: Hematology Authors: Lefrère JJ, Shiboski C, Fontanet A, Murphy EL Tags: Transfus Clin Biol Source Type: journals

[A one-year survey of an emergency released group O red blood cell stock used by a surgical treatment center.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The concentrates, used by the anaesthesiologists, are part of the treatment strategy care in case of severe bleeding. PMID: 19640756 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - July 26, 2009 Category: Hematology Authors: Vial J, Hoen JP, Floccard B, Thouverez B, Raba M, Allaouchiche B Tags: Transfus Clin Biol Source Type: journals

[Cell culture for transfusion purposes: The concept of "cultured red blood cells"]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One has been trying for several years to find a substitute for red blood cells (RBC). The development of chemical or natural molecules to replace hemoglobin has nevertheless proved difficult and artificial blood is still unattainable. We have described a methodology permitting the massive ex vivo production of mature human RBC having all the characteristics of native adult RBC from hematopoietic stem cells (HSC) of diverse origins: blood, bone marrow or cord blood. This protocol allows both massive expansion of the HSC/progenitors and their complete differentiation to the stage of perfectly functional mature RBC. The l...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Douay L Tags: Transfus Clin Biol Source Type: journals

[Genotyping of blood group systems at the CNRGS. I: FY, JK, MNS systems.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Usefulness of blood group genotyping in specialized immunohematology laboratories is obvious. However, the strategy for implementation of molecular methods remains to be defined. Use of high-throughput DNA analysis should change our way of working. PMID: 19386532 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Pham BN, Peyrard T, Ripaux M, Bourgouin S, Martin-Blanc S, Le Pennec PY, Rouger P Tags: Transfus Clin Biol Source Type: journals

[Immune thrombocytopenic purpura: Pathophysiology and treatment.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immune thrombopenic purpura (ITP) is an autoimmune disease characterized by a peripheral destruction of platelets. B lymphocytes play a key role but pathophysiology is more complex, involving humoral and cellular immunity associated with an inappropriate platelet production. The treatment of ITP is still based on uncontrolled studies. Prednisone and intravenous immunoglobulins remain the first line treatments. Splenectomy remains the best "curative" treatment for adults with chronic ITP. However, most patients are reluctant to undergo surgery and new treatments give promising results. Among them, rituximab and thrombop...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Godeau B Tags: Transfus Clin Biol Source Type: journals

[Fetal/neonatal alloimmune thrombocytopenias.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal and neonatal alloimmune thrombocytopenias result from maternal immunization against fetal specific platelet antigens inherited from the father that the mother lacks. The incidence has been estimated to one in 800 to one in 1000 live births. The most feared complication in case of severe thrombocytopenia is the occurrence of intracranial hemorrhage, leading to death or neurological sequelea. The diagnosis is straightforward when a maternal alloantibody is detected and the offending antigen identified in the infant. Any difficulties in confirming the diagnosis should not delay the treatment. Since the first descrip...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Kaplan C Tags: Transfus Clin Biol Source Type: journals

[Genotyping applied to platelet immunology: When? How? Limits.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Platelet alloantigens named Human Platelet Antigens (HPA) are involved in immune conflicts such as post-transfusion purpura, platelet transfusion refractoriness and neonatal alloimmune thrombocytopenia. Biological diagnosis relies on: (1) detection of alloantibodies; (2) identification of the alloantigen involved in the immune conflict. Since the development of methods based on molecular biology, platelet genotyping is preferred to phenotyping. Today, most of the Platelet Immunology Units use PCR-RFLP or PCR-SSP, and few use real-time PCR. An increasing amount of commercial kits based on new technologies is now availab...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Bertrand G, Kaplan C Tags: Transfus Clin Biol Source Type: journals

[Quantitative estimate of the risk of blood donation contamination by infectious agents.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this article is to update the last estimates of residual risks of the major transfusion-transmitted viral infections (HIV, HTLV, HCV and HBV) and to present the work realized by the working group << Quantitative estimate of the risk of blood donation contamination by infectious agents>>. PMID: 19409830 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Pillonel J, Brouard C, Laperche S, Barin F, Bernillon P, de Valk H, Tags: Transfus Clin Biol Source Type: journals

[Immunohematological surveillance of the pregnant woman: New prevention policy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the generalization of immunoprophylaxis by anti-RH immunoglobulins over 40 years, fetomaternal incompatibility due to RH1 antigen (RhD) is not completely eradicated, although perinatal consequences might be extremely serious. Additionally, allo-immunizations against other antigens, especially anti-RH4 (anti-c) and anti-KEL1 (anti-Kell), may cause severe haemolytic disease. Follow-up of allo-immunization during pregnancy and its prevention are therefore still a concern for all pregnant women. Immunohaematological tests used in antenatal patients are under practice for a long time. However, despite significant pr...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Mannessier L Tags: Transfus Clin Biol Source Type: journals

Protecting the blood supply from emerging pathogens: The role of pathogen inactivation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As a consequence of the many blood-safety interventions introduced since the mid-1980s, the major causes of transfusion-associated mortality have shifted from being mainly due to transfusion-transmitted infections (TTIs) to being mainly due to non-infectious serious events such as TRALI, hemolytic reactions, transfusion overload, and graft versus host disease. Thus, TTIs now account for only 10 to 15% of all transfusion associated mortalities! Relevantly, manufacturers of purified plasma protein fractions have, over the same time period, shown that pathogen inactivation technologies can be successfully implemented resu...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Blajchman MA Tags: Transfus Clin Biol Source Type: journals

[Some considerations on "regulation, practices and public health stakes" in blood transfusion.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19442551 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Marimbert J Tags: Transfus Clin Biol Source Type: journals

Pluripotent stem cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The isolation of human embryonic stem cells (ESC) in 1998 has created the hope that stem cells will one day be used to regenerate tissues and organs, even though it is obvious that a number of hurdles will need to be overcome for such therapies to become reality. The cloning of "Dolly" in 1997, more than 40 years after the first frogs were cloned, combined with the very fast progress made in our understanding of the molecular processes that govern the pluripotency of ESC has lead to the ability of scientists to recreate a pluripotent state in fibroblasts and other cells from mouse, rat and man, named induced pluripoten...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Verfaillie C Tags: Transfus Clin Biol Source Type: journals

[What plans need to be carried out to increase the plasma collection by the EFS?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The need of plasma derivatives increases in France. The Etablissement français du sang (EFS) carries out plans for supplying plasma to the Laboratoire français du fractionnement et des biotechnologies (LFB). Different kinds of actions are taken or will be taken according to the way of plasma processing. For plasma issued from whole blood, the increase is correlated with the increase of whole blood collection for the patients' need of red cells concentrates and the optimized plasma volume of plasma concentrate. For plasma issued from combined aphaeresis and the production of pooled platelets concentrates, synt...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Schneider T Tags: Transfus Clin Biol Source Type: journals

[Roles of an independent national French Society of Blood Transfusion in the European Union.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Learned societies are a reality in the medical sector. They are currently tending to become a federation of professionals, which targets are to secure the independence of training programs and perpetuate the scientific knowledge of blood transfusion. This is the way the French Society of Blood Transfusion (SFTS) built its role and scope of action in the service of patients. PMID: 19442554 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Rouger P Tags: Transfus Clin Biol Source Type: journals

[Tranfusion counseling.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this article, we present transfusion counseling; its organization, actors, their formations and we deal with factual positions. Transfusion counseling needs better identification, tending to a homogeneous organization between every bloodbank centre. PMID: 19442555 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Courbil R, Fabrigli P, Garraud O Tags: Transfus Clin Biol Source Type: journals

[Review of main haemovigilance systems in the world.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since 2002, major progress has occurred worldwide in the context of haemovigilance and significant improvement of the blood chain has come out as a result. Nevertheless different scenarios exist throughout the European Union and outside of Europe: the systems are mandatory or voluntary, notification is required for recipients, donors, processes or activities in the broad context of blood component transfusion. Differing from country to country, notification is mandatory for all adverse reactions or only for serious ones; and so it is with adverse events. Under-reporting is generally considered to be the most important ...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Faber JC Tags: Transfus Clin Biol Source Type: journals

[Biobanks and blood transfusion in France: A tool for public health.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Donor and recipient sample biobanks are a precious tool in hemovigilance studies as well as in epidemiological and biological research, in particular with regards to safety against blood-borne agents. This paper describes the main transfusion biobanks existing in France and gives their advantages and limits. The National blood donation biobank, organized for medicolegal reasons, preserves samples of each blood donation for a 5-year period. The biobank of the Blood and Organ Transmissible Infectious Agents (BOTIA) project stocks paired donor-recipient samples with a research objective. Preserved over a long period of ti...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Lefrère JJ, Coudurier N Tags: Transfus Clin Biol Source Type: journals

[TRALI and TACO: Diagnostic and clinical management.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transfusion-related acute lung injury (TRALI) is the inflammatory, exudative form and Transfusion-associated cardiac overload (TACO) is the hydrostatic, transudative form of transfusion-induced acute pulmonary edema. The distinction between these two entities may be difficult, but important because of different clinical management strategies and different implications. There is no unique diagnostic tool. The diagnostic search should gather several clinical information and may be helped by various techniques listed in this article. PMID: 19442558 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Ozier Y, Mertes PM Tags: Transfus Clin Biol Source Type: journals

[Cord blood grafts: Banking and indications.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A cord blood graft is now frequently used in the context of allogeneic hematopoietic transplantation. In 2007, 27% of unrelated allotransplantations performed in France used a cord blood graft. In comparison to other sources of hematopoietic grafts, cord blood has a number of advantages (immediate availability of the graft, possibility of a lesser HLA compatibility between donor and recipient...) and inconveniences (a limited number of stem cells, increased risk of infectious complications...). Recently, the possibility of combining two cord blood grafts has been demonstrated. In 2007, 55% of unrelated cord blood graft...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Tiberghien P, Chabod J, Deconinck E, Pouthier F Tags: Transfus Clin Biol Source Type: journals

[The contraindications in the blood donation. Impact of new rules.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ministerial decree of 12 January 2009 fixing the criteria for the selection of blood donors establishes the list of contraindications for blood donation according to the appendix to the European directive 2004/33/EC. This text regroups the preexisting guidelines and reinforces their regulatory status, which illustrates the importance attributed to the selection of donors within the dispositions ensuring transfusion safety. It introduces more flexibility with respect to the preexisting criteria taking into account the improvement in life expectancy and the continual increase in transfusion requirements. Thus, the ru...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Danic B, Bigey F Tags: Transfus Clin Biol Source Type: journals

[Transfusion of platelet concentrates.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although a number of research have been realized in the aim to rationalize the use of platelet concentrates, these blood products remain absolutely necessary for patients with therapeutic aplasia and for some surgical patients. We will discuss in this work: the main rules of platelet transfusion procedures, threshold values for platelet transfusion, platelet doses, place of curative and prophylactic strategies, refractoriness to platelet transfusion, HLA immunization. PMID: 19443251 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Bierling P Tags: Transfus Clin Biol Source Type: journals

[Pathogen inactivation in labile blood products.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The techniques for inactivation of pathogens in labile blood products (LBP) would appear to be the new strategy which will permit us to increase transfusion safety in the face of the risks of transmission of pathogenic agents by LBP. Various methods are in the course of development or already validated and used in France. The latter only apply however to plasma or platelet concentrates. The mechanisms of action and the efficacy of inactivation and attenuation of pathogenic agents vary with the different techniques. Each of these constitutes a preparative procedure composed of unit steps which have to be fully mastered ...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Naegelen C, Isola H, Dernis D, Maurel JP, Tardivel R, Bois S, Vignoli C, Cazenave JP Tags: Transfus Clin Biol Source Type: journals

[Platelet immunology and the immune response.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Platelets exert not only hemostatic activities, but also pro-inflammatory effects. Platelet-linked inflammation seems essentially related to their capacity of secreting cytokines, chemokines and related molecules. This activity is important in terms of concentration of secreted products. This secretory function confers to platelets a regulatory role in immunity. Besides, platelets do exhibit non-self infectious danger detection molecules on their surfaces, belonging in particular to the "Toll-like receptor family"; through this property, platelets can bind infectious agents but also deliver differential signals for the...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Garraud O, Cognasse F Tags: Transfus Clin Biol Source Type: journals

[Mechanisms of action of IVIG in autoimmune and inflammatory disorders: Recent developments.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite their widespread use since many years in autoimmune and inflammatory disorders, the mechanisms of action of IVIg have not been completely understood. These mechanisms depend on Fc and/or F(ab')2. IVIg interacts with the different components of the immune system: Fc receptors, complement, cytokines, T and B lymphocytes, dendritic cells, granulocytes and NK cells. Here, we discuss the recent advances in the understanding of the mechanisms of action of IVIg, in particular the importance of the sialylated Fc fragment. These advances maybe help us conceive better therapeutic strategies against autoimmune and inflamm...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Galeotti C, Maddur MS, Kazatchkine MD, Mouthon L, Kaveri SV Tags: Transfus Clin Biol Source Type: journals

[Cardiac cell therapy for acute myocardial infarction.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite important progress in cardiology, acute myocardial infarction (AMI) is the major cause of congestive heart failure and subsequent mortality. The rationale for cell therapy to be administered after AMI is derived from the assumption that given the insufficient regeneration in the injured heart tissue, stem cells from the bone marrow may be able to replace or repair damaged vascular and cardiac tissue. Results of the first phase I clinical trials using bone marrow stem/progenitor cell therapy for AMI were published in 2002 to 2004. Although not designed to test the efficacy of the intervention, the initial trials...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Lemarchand P Tags: Transfus Clin Biol Source Type: journals

[Understanding the role of the European public institutions in blood transfusion.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the context of increased demand of blood components, it is highly desirable to ensure development and implementation of established standards for ethical, organisational and regulatory fields in order to guarantee the sufficiency, quality and safety of blood components and their derivatives as well as the protection of donors and recipients. In Europe, the contributions of the European public institutions is fundamental for the achievement of these goals and for the harmonisation of practices inherent to transfusional medicine activities. The Council of Europe with its 47 member states constitutes the ideal platform...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Behr-Gross ME Tags: Transfus Clin Biol Source Type: journals

[Platelet transfusion: Products, indications, dose, threshold and efficacy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The quality of platelet concentrates had been greatly improved since the implementation of processing techniques based on the use of the buffy-coat in the years 1980. More recently, in the last 10 years, it is in the domain of safety that the greatest advances have been done, by the introduction of platelet additive solutions, on one hand, and by the progressive availability of pathogen reduction techniques, on the other hand. These developments in quality and safety of platelet components are important, as they lead to the conclusion that nowadays, apheresis platelet concentrates and pooled random donor platelet conce...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Andreu G, Vasse J, Tardivel R, Semana G Tags: Transfus Clin Biol Source Type: journals

[Operational qualification of the computer-based information system and electronic data interchanges in a hospital blood bank.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since 1985, a Council Resolution defines a new approach to technical harmonization and standards. The directives resulting from this new approach establish the essential safety requirements with which products put on the market must conform, and which should therefore enjoy free movement throughout the European Union, owing to a presumption of conformity. However, if the manufacturer is responsible for the conformity of its product in terms of safety, it is the end-user who must make sure that its requirements for a specific use or a considered application are satisfied and that the product meets its needs. It is the o...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Vaquier C, Legrand D, Caldani C Tags: Transfus Clin Biol Source Type: journals

[Work organisation improvement methods applied to Blood Transfusion Establishments (BTE): Lean Manufacturing, VSM, 5S.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These experiences, implemented in two BTE for different processes, confirm the applicability and usefulness of these methods to improve working organisations in BTE. PMID: 19446483 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Bertholey F, Bourniquel P, Rivery E, Coudurier N, Follea G Tags: Transfus Clin Biol Source Type: journals

[Pulmonary complications of transfusion: TACO and TRALI, a review.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary oedemas occurring during or after a blood transfusion appear as the most frequent serious immediate incidents in the French hemovigilance database. They include transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI). TACO are a major cause of transfusion-related death in France. TRALI are more and more recognized and notified. In no case, pooled fresh frozen plasma (100 donations) treated with solvent-detergent were involved in French TRALI cases. A logigrame will allow hemovigilance officers to better classify pulmonary oedemas in e-fit, the French hemovigilance ...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Renaudier P, Rebibo D, Waller C, Schlanger S, Vo Mai MP, Ounnoughene N, Breton P, Cheze S, Girard A, Hauser L, Legras JF, Saillol A, Willaert B, Caldani C Tags: Transfus Clin Biol Source Type: journals

[Automation in blood production.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The preparation of labile blood products in a blood bank is in permanent technological progress. Many operations, such as blood centrifugation, components separation, etc. are now performed by automated devices. A new generation of equipments is able to prepare blood products by reducing the number of manual operations. Therefore, buffy-coat platelet concentrate preparation and whole blood preparation can be prepared by these automated systems. Consequently, this directly impacts working conditions of employees, quality of blood products and process management. PMID: 19446485 [PubMed - in process] (Source: Transfus...
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Tardivel R, Bois S, Vignoli C, Naegelen C, Isola H Tags: Transfus Clin Biol Source Type: journals

[What is the future of blood safety and which safety strategy for an ultrasafe system?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article explains the scientific data and models on that type of systemic control and proposes a factual application to transfusion. PMID: 19447060 [PubMed - in process] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 30, 2009 Category: Hematology Authors: Amalberti R Tags: Transfus Clin Biol Source Type: journals

[Impact of socioeconomic status on blood donation.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Even when sociodemographic variables and self-rated health are considered, socioeconomical status stays associated to blood donor status. Thus, this article highlights the importance of socioeconomic status in the blood donors' population structure. This study also shows that occasional donors, that should be resensitized, belong to the same socioeconomical categories than regular donors. Finally, this article provides research and sensitizing clues for some of the socioeconomic status analysed. PMID: 19372060 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - April 13, 2009 Category: Hematology Authors: Duboz P, Cunéo B Tags: Transfus Clin Biol Source Type: journals

[Blood transfusion assessment to 112 homozygous sickle-cell disease patients in university hospital of Brazzaville.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to assess the short-term efficiency of the red cell transfusion in SCD homozygous form. One hundred and twelve homozygous sickle-cell patients were enrolled in this prospective study: 59 females and 53 males, median age is 21,8 years (extremes: 2 and 45 years). These patients are mostly with very low income. Two groups of patients are included in this study. In the first group, patients present acute anemia crisis caused by infections disease (malaria, bacterial infections). In the second group (20 cases), SCD patients have particularly situations: pregnancy (10 cases); stroke (six cases); cardiac failure (...
Source: Transfusion Clinique et Biologique - April 12, 2009 Category: Hematology Authors: Elira Dokekias A, Ngolet Ossini L, Atipo Tsiba FO, Malanda F, Koko I, De Montalembert M Tags: Transfus Clin Biol Source Type: journals

[Acute repeating hemolytic anemia as the first manifestation of Wilson's disease: Report of a case.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of Wilson's disease revealed by acute intravascular repeating hemolytic anemia associated with liver failure. The initially negative etiologic investigation was directed by occurred of liver failure. The genetic study allowed to discover an other similar case. The evolution was favourable under treatment with zinc sulfate and penicillamine. DISCUSSION: Diagnosis of Wilson's disease must be considered in case of acute hemolytic anemia associated with liver failure in young adults. PMID: 19329346 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 27, 2009 Category: Hematology Authors: El Khattabi A, Seddik H, Fatihi J, Salaheddine H, Badaoui M, Amézyane T, Mahassine F, Ohayon V Tags: Transfus Clin Biol Source Type: journals

[Hypotension and adverse transfusion reactions: From the associated clinical sign to the hypotensive transfusion reaction.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In about three cases out of four, transfusion-induced hypotension was associated with other clinical reactions. Indeed, hypotensive transfusion reactions were identified, having an incidence of 3.2 for 100000 blood units transfused. Furthermore, there was no explanation found for the incidence increase in our region during 2007. A national study was suggested to analyse the national data as well as a prospective study to clear out this type of transfusion reactions. PMID: 19328031 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 25, 2009 Category: Hematology Authors: Py JY, Leo-Kodeli S, Fauveau L, Duedari N, Roubinet F Tags: Transfus Clin Biol Source Type: journals

[Regionalization's experience of tranfusionnel advice.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We represent an organization of transfusionnel advice at a regional level and we develop arguments and stages having allowed us to lead to this choice. This target was reached in two stages, which took place over 3 years. The regional transfusionnel advice leans on three fundamental points: a planned permanent organization, skilled and formed actors as well as adapted tools. Tending to a homogeneous organization between every blood bank center seems to be coherent towards the current configuration of blood donation in France. PMID: 19324582 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)
Source: Transfusion Clinique et Biologique - March 24, 2009 Category: Hematology Authors: Courbil R, Fabrigli P, Benamara H, Chavarin P, Bregeon M, Ruyer-Dumontier P, Goure D, Paulin P, Froget A, Taibi K, Rigal E, Garraud O Tags: Transfus Clin Biol Source Type: journals

[Who uses blood? Results of a cross-sectional and nation wide survey.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the years 1994-2001, a progressive decrease of the number of blood units transfused has been reported in France. In contrast, since 2002, there is an increasing number of blood units issuing (+7.6% between 2001 and 2006) and this must be investigated. On behalf of the French Society of Blood Transfusion, the "Recipients" working group promoted a nation wide survey with the support of the regional blood transfusion centres. This survey was aimed at describing the profiles of the transfused patients: socio-demographical patterns, and reasons of the blood transfusion (main and associated diagnoses). A cross-sectio...
Source: Transfusion Clinique et Biologique - March 20, 2009 Category: Hematology Authors: Quaranta JF, Berthier F, Courbil R, Courtois F, Chenais F, Waller C, Leconte des Floris MF, Andreu G, Fontaine O, Le Niger C, Puntous M, Mercadier A, Nguyen L, Pélissier E, Gondrexon G, Staccini P, Tags: Transfus Clin Biol Source Type: journals