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Announcement: Case ReportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Information for ContributorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Will Publish in Future IssuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Journal ClubEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Sunny Dzik, Jeannie Callum, Richard Haspel Source Type: journals

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THIS MULTIAUTHORED TEXTBOOK published in 2008 is devoted entirely to transfusion safety and transfusion-transmitted infections and their prevention. The book containing 28 chapters is organized into 3 sections. The first section describes the basic characteristics of various classes of infectious agents (eg, hepatitis viruses, retroviruses, herpes viruses, bacteria, protozoa, and prions). The second section covers donor selection and testing and covers the operational aspects of these subjects. The third section—entitled surveillance, risk, and regulation—covers a variety of operational and research topics under this g...
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Steve Kleinman Tags: Book Review Source Type: journals

Transfusion Medicine in Chicago, Before and After the “Blood Bank”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although history states correctly that Bernard Fantus coined the name “blood bank” in Chicago in 1937, his was only one of many contributions of Midwest America to the new therapy of blood transfusion. Chicago was at the center of the movement before and after then, anticipating the modern era with the first practical method for direct donor-to-recipient transfusion and staging a secret clinical trial of cadaver blood. That successful trial of cadaver blood may have presaged the first functional cadaver kidney transplant, performed at the same hospital several years later. Modern-day technologies for blood collection, ...
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Glenn Ramsey, Paul J. Schmidt Tags: Pioneers and Pathfinders Source Type: journals

Blood Group Antigens and Normal Red Blood Cell Physiology: A Canadian Blood Services Research and Development SymposiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Presented by Donald R. Branch, PhD, Canadian Blood Services, Research and Development and Department of Medicine, University of Toronto, Toronto, Ontario, Canada Research and development (R&D) continues to be an important component of the overall mandate of the Canadian Blood Services (CBS) which is to provide safe blood products for transfusion to all Canadians. The CBS R&D program has been organized to address specific areas of research, represented as research “hubs” located in different geographical locations throughout Canada. Transfusion immunology is the focus of the Toronto Hub and an annual international symp...
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Yulia Lin, Katerina Pavenski, Elianna Saidenberg, Donald R. Branch Source Type: journals

Filling a Gap in Transfusion Medicine Education and ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After the outbreak of the HIV/AIDS epidemic, attention was focused on the restructuring and reorganization of nationally supported safe and sustainable blood supply systems. Networking and human capacity building in transfusion medicine were developed through World Health Organization initiatives. Educational materials were created for the core elements of the blood transfusion chain. However, the management aspects of transfusion medicine as well as applied health science research in transfusion medicine were not addressed. In 2000, the World Health Organization initiated the creation of the Academic Institute for Interna...
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Cees Th. Smit Sibinga Source Type: journals

The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews TRALI pathophysiology, explores the role of the neutrophil, details practical information for appropriate diagnosis and promotes further studies into the pathogenesis of TRALI. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Yoke Lin Fung, Christopher C. Silliman Source Type: journals

Controversy in Trauma Resuscitation: Do Ratios of Plasma to Red Blood Cells Matter?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since a report in October 2007 of dramatic improvements in trauma mortality in a military population when massive transfusion of red blood cells (RBC) was accompanied by plasma replacement at 1:1 proportions, interest in the plasma-to-RBC ratio during resuscitation in both the trauma and transfusion communities has been intense. Over the 7-month period from August 2008 through February 2009, a further 9 major studies examining experience with plasma replacement in massively transfused civilian trauma patients have been published. This flood of observational studies is likely to continue. In this review, the authors examine...
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Lynn G. Stansbury, Richard P. Dutton, Deborah M. Stein, Grant V. Bochicchio, Thomas M. Scalea, John R. Hess Source Type: journals

Editorial: “Formula-Driven” Versus “Lab-Driven” Massive Transfusion Protocols: At a State of Clinical EquipoiseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IN 2006 IN the Journal of Trauma, Drs Malone, Hess, and Fingerhut recommended the adoption of 1:1:1 resuscitation (red blood cells [RBC]/fresh frozen plasma [FFP]/platelet). They recommended that such a protocol “be fully developed and examined in a clinical trial.” In the meantime they recommended its use during the “early chaotic phase of resuscitation to standardize blood product support.” They also stated “it should also encourage blood banks to remove impediments to rapid blood product delivery,” citing an article recommending 4 new blood transfusion “services” for trauma patients: (1) thawed FFP; (2) ...
Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Authors: Jeannie L. Callum, Bartolomeu Nascimento, Homer Tien, Sandro Rizoli Source Type: journals

MastheadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - September 17, 2009 Category: Hematology Source Type: journals

Information for ContributorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Will Publish in Future Issues . . .Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Journal ClubEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Richard Haspel, Sunny Dzik, Jeannie Callum Source Type: journals

Blood Transfusion in World War I: The Roles of Lawrence Bruce Robertson and Oswald Hope Robertson in the “Most Important Medical Advance of the War”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The demonstration and acceptance of the life-saving potential of blood transfusion in the resuscitation of combat casualties came in two parts. First, Canadian surgeon Major Lawrence Bruce Robertson showed that direct transfusion of uncrossmatched blood from the veins of a donor to a patient could save the lives of many moribund casualties, even if a few died of acute hemolytic reactions. Second, US Army Captain Oswald Hope Robertson showed that stored, syphilis-tested, universal donor whole blood could be given quickly and safely in forward medical units. With these demonstrations, the Royal Army Medical Corps adopted tra...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Lynn G. Stansbury, John R. Hess Tags: Pioneers and Pathfinders Source Type: journals

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THE TOPIC OF immunohematological methods deserves a prominent place among the concerns of blood bankers because of the plethora of methods that exist and the fact that adequate training for many bench technologists who might be faced with serological incompatibilities is not as common as it once was. Thus, books that clearly indicate appropriate methods to be used for specific serological problems are extremely valuable. This latest edition of the previously titled Methods in Immunohematology provides the comprehensiveness and clarity for those individuals interested in serological (immunohematological) investigations. It ...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Donald R. Branch Tags: Book Reviews Source Type: journals

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THIS IS AN up-to-date text on transfusion-related acute lung injury (TRALI) by 2 individuals well versed in the field, Dr Steven Kleinman and Dr Mark Popovsky. They have assembled a number of transfusion medicine specialists to author most of the chapters and provide a comprehensive overview of TRALI. The chapters tend to be well referenced and are nicely illustrated; however, there is some duplication between chapters. Especially useful is a table, in chapter 2, on the differential diagnosis of pulmonary transfusion reactions. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Paul V. Holland Tags: Book Reviews Source Type: journals

Guidelines for Managing Conscientious Objection to Blood TransfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parents sometimes deny their children blood transfusion because of their religious beliefs. The Japanese Joint Committee on the Refusal of Blood Transfusion on Religious Grounds asserts that the health and life of every child younger than 15 years should be guarded by the collective efforts of health, welfare, and advocacy institutions when a parent or guardian seeks to withhold transfusion therapy. Patients 18 years or older should receive treatment without transfusion after signing and submitting a “Certificate of Refusal Blood Transfusion and Exemption from Liability.” For a patient younger than 18 years, but 15 yea...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Hitoshi Ohto, Yuji Yonemura, Junzo Takeda, Eiichi Inada, Ryoji Hanada, Satoshi Hayakawa, Takeshi Miyano, Katsunori Kai, Waichiro Iwashi, Kaori Muto, Fumikazu Asai Source Type: journals

Selection Criteria to Protect the Blood Donor in North America and Europe: Past (Dogma), Present (Evidence), and Future (Hemovigilance)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The safety of the blood supply depends on measures to protect not only the transfusion recipient but also the blood donor. Donor selection criteria have been voluntarily adopted or enforced through regulation in different countries, but review of practices in different blood centers reveals wide disparity in the current approaches. Such variability in practice suggests that the criteria for the protection of donor are often arbitrary or reflect deeply engrained precautionary practices and exposes the inherent uncertainty about the best way to minimize risk to the donor. Certain selection criteria introduced years ago have ...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Anne Eder, Mindy Goldman, Susan Rossmann, Dan Waxman, Celso Bianco Source Type: journals

Antigen Loss From Antibody-Coated Red Blood CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinically significant signs and symptoms of hemolysis can result from the transfusion of crossmatch incompatible blood, the development of anti–red blood cell (RBC) alloantibodies posttransfusion, or the development of autoantibodies to RBCs (ie, autoimmune hemolytic anemia). However, a less understood and poorly appreciated phenomenon is when an antibody induces the loss of its target antigen without significant damage to the cells themselves. This has been referred to as “depressed antigen,” “antigen suppression,” “weakened antigenicity,” and “antigen loss.” This phenomenon has been observed for multip...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: James C. Zimring, Chantel M. Cadwell, Steven L. Spitalnik Source Type: journals

Cryoprecipitate: The Current State of KnowledgeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cryoprecipitate is a diverse product containing factor VIII, von Willebrand factor, fibrinogen, fibronectin, factor XIII, and platelet microparticles. The role of this complex product in the management of hemostasis has not been well studied (excluding patients with factor VIII deficiency). There are insufficient data to determine the clinical setting where this product might be clinically efficacious despite its widespread use in multiple different clinical scenarios. The best method of pooling before transfusion has also not been thoroughly investigated to determine the optimal infusion strategy (intralaboratory vs bedsi...
Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Authors: Jeannie L. Callum, Keyvan Karkouti, Yulia Lin Source Type: journals

MastheadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - June 25, 2009 Category: Hematology Source Type: journals

Information for ContributorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Will Publish in Future Issues...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Tags: Frontmatter Source Type: journals

Announcement: Case ReportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Source Type: journals

Journal ClubEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Sunny Dzik, Jeannie Callum, Richard Haspel Source Type: journals

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IT HAS BEEN many years, if not decades, since a transfusion medicine serologic handbook has been published cataloguing the various blood group antigens and antibodies. These authors, senior serologic scholars from one of the world's largest blood centers, have magnificently simplified and displayed the complex world of human red blood cell (RBC) serology (immunohematology), reinforced their clinical significance and presented other useful facts about blood group antigens and antibodies. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Leo J. McCarthy, Alvin Limiac Tags: Book Review Source Type: journals

Cees Th. Smit Sibinga: An AutobiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cees Smit Sibinga was born in 1939 in Makassar in the former Dutch East Indies and spent the first part of his life in a Japanese internment camp. This experience was extremely important for the development of his attitude in and philosophy of life, in which a positive fighter spirit predominates. He subsequently studied medicine, specializing in clinical hematology, and then did his PhD at the University of Groningen. In 1976, he became the Regional Blood Bank Director for the northern part of the Netherlands, which he shaped into a model blood bank. Since 1976, for 28 years, he annually organized an international symposi...
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Cees Th. Smit Sibinga Tags: Pioneers and Pathfinders Source Type: journals

Severe Hemolytic Anemia Post–Renal Transplantation Produced by Donor Anti-D Passenger Lymphocytes: Case Report and Literature ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present a case of severe hemolytic anemia related to the PLS in an ABO-matched renal allograft recipient. The recipient's blood type was A Rh(D) positive; and the donor, who had been previously alloimmunized, was A Rh(D) negative. The renal allograft recipient's hemoglobin abruptly decreased on postoperative day 12 in the setting of a newly positive direct antiglobulin test and anti-D antibodies in the plasma. The patient required intermittent RBC transfusions for ongoing hemolysis during the first 6 months post–renal transplant. Of all reported cases of anti-D–mediated PLS, our patient would seem to...
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Craig D. Ainsworth, Mark A. Crowther, Darin Treleaven, Denise Evanovitch, Kathryn E. Webert, Morris A. Blajchman Tags: Case Report Source Type: journals

Rapid and Accurate In Vitro Assays for Detection of West Nile Virus in Blood and TissuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
West Nile virus (WNV) is a mosquito-borne single-stranded RNA virus, which has relatively recently emerged as a blood transfusion and organ transplantation transmissible pathogen. Low levels of WNV (viremia) are found in asymptomatic blood transfusion or cell/tissue donors with an infection, which poses a health threat to recipients. Since the introduction of nucleic acid testing (NAT) in 2003, many changes have occurred in the field of WNV detection and diagnosis. This review will focus on the recent progress in the in vitro assays for rapid and accurate detection of WNV in blood and tissues. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Wandong Zhang, Jun Wu, Yan Li, Fengshan Li, Howard Njoo Source Type: journals

Passenger Lymphocyte Syndrome With or Without Immune Hemolytic Anemia in all Rh-Positive Recipients of Lungs From Rhesus Alloimmunized Donors: Three New Cases and a Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this report suggests a high incidence of Rhesus antibody PLS after lung transplantation, with wide variations in the timing of antibody onset, persistence, and severity. A review of the phenomenon and its implications are discussed. (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Christine M. Cserti-Gazdewich, Thomas K. Waddell, Lianne G. Singer, Cecilia Chaparro, Jacob M. Pendergrast, Janice Hawes, Neal denHollander, Kathryn Tinckam, Shaf Keshavjee Source Type: journals

Properties of Pathogen-Inactivated Plasma ComponentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are now 4 licensed technologies available for the pathogen inactivation of fresh frozen plasma in Europe. None of these are currently available in the United States, whereas in other geographic regions some are licensed others are not. This review addresses the different technologies available for the pathogen inactivation of plasma, their impact on the potency of the product, their efficacy in addressing microbiological contamination, as well as summarizing potential immunologic and toxicologic concerns. Published evidence of clinical efficacy is also reviewed as are various approaches to determining cost-effectiven...
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Christopher Prowse Source Type: journals

Blood Iron Homeostasis: Newly Discovered Proteins and Iron ImbalanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In biological systems, iron exerts 2 contrasting effects. The chemical reactivity of iron is essential for the biological activities of proteins such as hemoglobin, ribonucleotide reductase, the cytochromes, and aconitases. However, free iron in a cell has the propensity to generate free radicals which can damage cellular components containing proteins, lipids, and nucleic acids. To maintain the balance between iron as an essential nutrient and iron as a potential cytotoxin, a number of biological protective mechanisms have evolved. As shown in the thalassemias, iron imbalance can have devastating effects on human health. ...
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Mark R. Bleackley, Ann Y.K. Wong, David M. Hudson, Christopher H-Y. Wu, Ross T.A. MacGillivray Source Type: journals

Scientific Background on the Risk Engendered by Reducing the Lifetime Blood Donation Deferral Period for Men Who Have Sex With MenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The lifetime deferral for men who have sex with men (MSM) has not been harmonized with the 12-month deferral for similar-risk activities through heterosexual contacts. This occurs primarily because of fears of increased transfusion transmission of known sexually and transfusion-transmitted viruses for which donor blood is (eg, HIV) or is not (eg, human herpesvirus 8 [HHV-8]) tested and also of fears of novel agents that may share the epidemiology and long asymptomatic phase of HIV. A 12-month MSM deferral could result in release of 1 HIV-infectious donation every 11 years in the United States. This risk is smaller than the...
Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Authors: Eleftherios C. Vamvakas Source Type: journals

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Source: Transfusion Medicine Reviews - April 1, 2009 Category: Hematology Source Type: journals

Scientific background on the risk engendered by reducing the lifetime blood donation deferral period for men who have sex with men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The lifetime deferral for men who have sex with men (MSM) has not been harmonized with the 12-month deferral for similar-risk activities through heterosexual contacts. This occurs primarily because of fears of increased transfusion transmission of known sexually and transfusion-transmitted viruses for which donor blood is (eg, HIV) or is not (eg, human herpesvirus 8 [HHV-8]) tested and also of fears of novel agents that may share the epidemiology and long asymptomatic phase of HIV. A 12-month MSM deferral could result in release of 1 HIV-infectious donation every 11 years in the United States. This risk is smaller than...
Source: Transfusion Medicine Reviews - March 25, 2009 Category: Hematology Authors: Vamvakas EC Tags: Transfus Med Rev Source Type: journals

Blood iron homeostasis: newly discovered proteins and iron imbalance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In biological systems, iron exerts 2 contrasting effects. The chemical reactivity of iron is essential for the biological activities of proteins such as hemoglobin, ribonucleotide reductase, the cytochromes, and aconitases. However, free iron in a cell has the propensity to generate free radicals which can damage cellular components containing proteins, lipids, and nucleic acids. To maintain the balance between iron as an essential nutrient and iron as a potential cytotoxin, a number of biological protective mechanisms have evolved. As shown in the thalassemias, iron imbalance can have devastating effects on human heal...
Source: Transfusion Medicine Reviews - March 25, 2009 Category: Hematology Authors: Bleackley MR, Wong AY, Hudson DM, Wu CH, Macgillivray RT Tags: Transfus Med Rev Source Type: journals

Properties of pathogen-inactivated plasma components.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are now 4 licensed technologies available for the pathogen inactivation of fresh frozen plasma in Europe. None of these are currently available in the United States, whereas in other geographic regions some are licensed others are not. This review addresses the different technologies available for the pathogen inactivation of plasma, their impact on the potency of the product, their efficacy in addressing microbiological contamination, as well as summarizing potential immunologic and toxicologic concerns. Published evidence of clinical efficacy is also reviewed as are various approaches to determining cost-effect...
Source: Transfusion Medicine Reviews - March 25, 2009 Category: Hematology Authors: Prowse C Tags: Transfus Med Rev Source Type: journals

Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this report suggests a high incidence of Rhesus antibody PLS after lung transplantation, with wide variations in the timing of antibody onset, persistence, and severity. A review of the phenomenon and its implications are discussed. PMID: 19304114 [PubMed - in process] (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - March 25, 2009 Category: Hematology Authors: Cserti-Gazdewich CM, Waddell TK, Singer LG, Chaparro C, Pendergrast JM, Hawes J, denHollander N, Tinckam K, Keshavjee S Tags: Transfus Med Rev Source Type: journals

Rapid and accurate in vitro assays for detection of West Nile virus in blood and tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
West Nile virus (WNV) is a mosquito-borne single-stranded RNA virus, which has relatively recently emerged as a blood transfusion and organ transplantation transmissible pathogen. Low levels of WNV (viremia) are found in asymptomatic blood transfusion or cell/tissue donors with an infection, which poses a health threat to recipients. Since the introduction of nucleic acid testing (NAT) in 2003, many changes have occurred in the field of WNV detection and diagnosis. This review will focus on the recent progress in the in vitro assays for rapid and accurate detection of WNV in blood and tissues. PMID: 19304115 [PubMe...
Source: Transfusion Medicine Reviews - March 25, 2009 Category: Hematology Authors: Zhang W, Wu J, Li Y, Li F, Njoo H Tags: Transfus Med Rev Source Type: journals

Severe hemolytic anemia post-renal transplantation produced by donor anti-D passenger lymphocytes: case report and literature review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present a case of severe hemolytic anemia related to the PLS in an ABO-matched renal allograft recipient. The recipient's blood type was A Rh(D) positive; and the donor, who had been previously alloimmunized, was A Rh(D) negative. The renal allograft recipient's hemoglobin abruptly decreased on postoperative day 12 in the setting of a newly positive direct antiglobulin test and anti-D antibodies in the plasma. The patient required intermittent RBC transfusions for ongoing hemolysis during the first 6 months post-renal transplant. Of all reported cases of anti-D-mediated PLS, our patient would seem to hav...
Source: Transfusion Medicine Reviews - March 25, 2009 Category: Hematology Authors: Ainsworth CD, Crowther MA, Treleaven D, Evanovitch D, Webert KE, Blajchman MA Tags: Transfus Med Rev Source Type: journals

Cost-Effectiveness Analysis: What It Really Means for Transfusion Medicine Decision Making.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some have suggested that "blood is different," and the role for cost-effectiveness is thus circumscribed. In this article, the authors start by reviewing key concepts in health economics and economic analysis methods. Examples are drawn from published blood safety studies. After explaining the underlying reasoning behind cost-effectiveness analysis, the authors point out how economic thinking is evident in some aspects of transfusion medicine. Some cost-effectiveness study results for blood safety are discussed to provide context, followed by consideration of prominent decisions that have been made in transfusion medic...
Source: Transfusion Medicine Reviews - December 7, 2008 Category: Hematology Authors: Custer B, Hoch JS Tags: Transfus Med Rev Source Type: journals

Animal Models of Transfusion-Related Acute Lung Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the current status of the known experimental models of TRALI, with particular emphasis on efforts to establish in vivo animal models of this important pulmonary transfusion reaction. PMID: 19056031 [PubMed - as supplied by publisher] (Source: Transfusion Medicine Reviews)
Source: Transfusion Medicine Reviews - December 7, 2008 Category: Hematology Authors: Lögdberg LE, Vikulina T, Zimring JC, Hillyer CD Tags: Transfus Med Rev Source Type: journals