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Upcoming EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Tags: Upcoming Events Source Type: journals

Dengue virus during blood donation: Pre-screen using NS1 antigenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estimates for dengue transmission during blood donations have been upsetting in diverse geographical locations. During the 2004 dengue virus (DENV) outbreak in Cairns, Australia, the risk of collecting a viremic donation could have been as high as 1 in 1028 during the peak of the outbreak . Using a mathematical model and assuming a ratio of asymptomatic to symptomatic infections of 2:1–10:1, the risk for dengue-infected blood transfusions in Singapore, a city-state in Asia, during 2005 was estimated to be 1625–6/10,000 blood transfusions . In a tertiary care teaching hospital that provides care in Northeast Mexico, 800...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Subhash C. Arya, Nirmala Agarwal Tags: Letter to the Editor Source Type: journals

The clinical trials sectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this issue of Transfusion and Apheresis Science we are introducing a new section which will address clinical trials. Dr. Ramlow from Rostock, Germany has agreed to take on the responsibility of Editor of this section. The purpose of this section will be to share information concerning proposed, ongoing or completed clinical trials with an international audience. We encourage our readers to let Dr. Ramlow know of any trials and/or provide their comments on such. He can be reached at: (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Wolfgang Ramlow, Gail Rock Tags: Clinical Trials Source Type: journals

The potential usefulness of thrombelastography in quality monitoring and quality improvement of blood componentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombelastography (TEG) technology is a cell-based methodology for analysis of the viscoelastic changes that occur during coagulation of a whole blood sample in vitro, providing a unique opportunity to evaluate initiation, propagation, formation and stability of the clot strength of citrated blood and the derived haemostatic components. The potential clinical applications of modern TEG are well established. This brief report deals with additional potential applications of TEG in quality monitoring of haemostatic blood components, for clinical use. This is of particular relevance as with the recent technological advances, ...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Jerard Seghatchian Tags: What's Happening Source Type: journals

Clinical trials for pathogen reduction in transfusion medicine: A reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Despite the implementation of highly sensitive methods for the detection of pathogens in donor blood products, the risk of transmission of infectious disease to transfusion recipients remains. Of greatest concern, and accounting for most of the risk, are newly-emerging pathogens for which screening assays do not yet exist or well-known pathogens for which testing regimens are not routinely employed. Furthermore, passive donor screening programs are unlikely to capture all potentially infective donors. A promising strategy to overcome these limitations is the proactive incapacitation of pathogens residing in donor...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: John McClaskey, Mina Xu, Edward L. Snyder, Christopher A. Tormey Tags: Guest Editor: Stephen J. Wagner Source Type: journals

Extracorporeal photo-apheresis for the treatment of steroid-resistant graft versus host diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Acute and chronic graft versus host disease are frequent and potentially severe complications of allogeneic hematopoietic stem cell transplantation and are among the leading causes of non-relapse transplant-related mortality. For patients with steroid refractory disease, prognosis is particularly poor and although a variety of treatment options are available, responses are commonly transient and the side effects often intolerable. Since it was first introduced for the treatment of cutaneous T-cell lymphoma, extracorporeal photo-apheresis has been utilized as an immunomodulatory therapy for certain autoimmune dise...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Kristin Baird, Alan S. Wayne Tags: Guest Editor: Stephen J. Wagner Source Type: journals

BiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Wagner obtained a B.S. in Chemistry (1977) at the University of Maryland and an M.S. (1979) and Ph.D. (1981) in Biophysics at the Pennsylvania State University. He joined the American Red Cross in 1989 as a scientist at the Holland Laboratory. He is a recipient of the Red Cross Tiffany Award and currently is a Director of Pathogen Management and Blood Product Improvement with the Blood Components Department. At the Holland Laboratory, Dr. Wagner has led groups which conduct developmental research in bacterial growth and detection in blood components, and in methods for pathogen reduction of blood components. He current...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Stephen J. Wagner Tags: Guest Editor: Stephen J. Wagner Source Type: journals

Illuminating blood componentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The focus of this volume’s guest section is on the use of light with photochemicals to treat blood components. Some photochemical treatments of blood cause the formation of nucleic acid adducts and crosslinks in both leukocytes and infectious agents, ultimately leading to their apoptosis or inactivation, respectively. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Stephen J. Wagner Tags: Guest Editor: Stephen J. Wagner Source Type: journals

The influence of riboflavin photochemistry on plasma coagulation factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: As with other pathogen reduction procedures for plasma products, treatment with riboflavin and UV light resulted in reduction in the activity levels of several pro-coagulant factors. Coagulation inhibitors are well preserved. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Luis Larrea, María Calabuig, Vanesa Roldán, José Rivera, Han-Mou Tsai, Vicente Vicente, Roberto Roig Tags: Submitted Papers Source Type: journals

Motivators and barriers to blood donation in African American college studentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: African Americans female college students are willing to donate blood given convenience and support from their university. Educational campaigns to increase knowledge regarding the safety of the blood donation process and the ongoing needs of an adequate blood supply might be effective methods to increase blood donation. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Beth H. Shaz, Derrick G. Demmons, Colleen P. Crittenden, Claudine V. Carnevale, Mark Lee, Miriam Burnett, Kirk Easley, Christopher D. Hillyer Tags: Submitted Papers Source Type: journals

Homing of lin−/CD117+ hematopoietic stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the homing of hematopoietic stem cells (HSCs) to non-hematopoietic tissues in lethally irradiated (9Gy) hybrid mice transplanted intravenously with lin−/CD117+ bone marrow cells from ROSA26 mice. The numbers of CFU-GM in spleen of irradiated transplanted mice were well above the levels found in non-irradiated group as early as day 8 after transplant. On 12th day regeneration of lymphocytes was observed, an increase in granulocytes was detected as late as on 33rd day. Transplanted cells containing lacZ gene were detected in recipient mice by histochemistry and their location in the thymus, live...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Stanislav Filip, Jaroslav Mokrý, Jiřina Vávrová, Dana Čížková, Zuzana Šinkorová, Vlasta Tošnerová, Milan Bláha Tags: Submitted Papers Source Type: journals

Blood transfusion therapy for 41 earthquake casualtiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Blood transfusion was an effective therapy for the earthquake casualties. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Zhongjun Li, Weidong Wang, Te Chen Tags: Submitted Papers Source Type: journals

The association of gender, age, body mass index, and vital signs in healthy plateletapheresis donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In order to determine the association between gender, age, body mass index and vital signs among healthy plateletapheresis donors, the mean and median values from the most recent donations of 236 plateletapheresis donors were calculated for age, body mass index (BMI), oral temperature, blood pressure (BP), and pulse. Values of these parameters were compared after stratification by gender, age, and BMI and multiple regression analysis between parameters performed. Gender, age, and BMI were associated with significant differences in vital signs of healthy plateletapheresis donors. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Caroline E. Boeke, Megan E. Pauly, Holly Hatch Stock, Stephanie Pavlis, J. Brooks Jackson Tags: Submitted Papers Source Type: journals

Anti-haptoglobin antibody detection after febrile non-hemolytic transfusion reactions in a non-haptoglobin-deficient patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe herein a patient with FNHTR after the transfusion of leukoreduced single-donor apheresis platelet concentrates (LR-PC). (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Tsuyoshi Muta, Makiko Ozaki, Takahito Tokuyama, Kenichi Izumi, Miki Matsushita, Noriko Nishiyama, Hidemoto Nakanishi, Yoko Ueda, Tomoaki Fujisaki, Eisuke Yokota Tags: Submitted Papers Source Type: journals

The effect of blood donation frequency on iron statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Adjusting the donation intervals is a way to prevent iron deficiency in blood donors. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: A.S. Røsvik, R.J. Ulvik, T. Wentzel-Larsen, T. Hervig Tags: Submitted Papers Source Type: journals

ESFH membership application formEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Tags: International Forum: Germany Source Type: journals

Editorial–Issue 41.3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The title of the theme in this issue is Illuminating Blood Components. This section, which was put together by one of the new members of the Editorial Board, Dr. Stephen Wagner, addresses issues related to exposure of blood components to various light sources. There is an interesting article on use of photopheresis in the treatment of Graft versus Host disease and this is followed by a review of the various clinical trials for pathogen reduction in Transfusion Medicine. The majority of the pathogen reduction methods involve exposure to either UV or other light sources. While a great many units of SDP and methylene blue tre...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Gail Rock Source Type: journals

Editorial board/Publication informationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Source Type: journals

Upcoming eventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Tags: Upcoming Events Source Type: journals

Red cell exchange employing phenotypically matched deglycerolized red blood cells to treat acute sickle cell crisis: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Red blood cell (RBC) transfusion in sickle cell patients, especially young recipients, is at high risk for multiple reasons. The high susceptibility to develop alloantibodies, together with haemolytic transfusion reactions that would impair future transfusion therapy imposes the choice of RBC concentrates respecting as much as possible, the patient’s phenotype . Furthermore ethnic difference between donors and RBC recipients is critical to heighten the possibility of alloimmunization against foreign antigens. Sickle cell crisis is a very severe painful condition resulting in tissue infarction of different organs (brain, ...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Cesare Perotti, Paola Isernia, Claudia Del Fante, Gianluca Viarengo, Laura Salvaneschi, Maurizio Marconi, Maria Antonietta Villa Tags: Letter to the Editor Source Type: journals

Quality assurance of the donor questionnaire and donor interview: A three year experience with an electronic donor questionnaireEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Quality assurance of the donor questionnaire and the donor interview must ensure that all relevant questions about donor eligibility are answered and documented in a reliable format. The use of the self explanatory, electronic donor information tool [EDIT], not only provided a harmonized and standardised system of quality assurance but also saved time and can be easily modified as guidelines change. This brief report highlights the principles of this tool and some of its potential benefits, as experienced over the 3years since its introduction in Norway. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: O. Flesland, J. Seghatchian Tags: What's Happening? Source Type: journals

Platelet utilization in the developing world: Strategies to optimize platelet transfusion practicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There is perennial shortage of blood and blood components in most of the developing world. The resources are inadequate in terms of meeting the ever growing demand of blood components especially platelets. A poor health care system has led to underdevelopment of blood transfusion services which ultimately affect the transfusion practices. There is a paucity of comprehensive data on the platelet usage from the developing countries which is reflective of their modest development in blood component therapy. This is in sharp contrast to the fast pace of development in platelet transfusion practice in developed world ...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Anupam Verma, Prashant Agarwal Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Problem of bacterial contamination in platelet concentratesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Bacterial contamination of blood is being recognized more frequently now and is one of the serious complications of transfusion. Use of integrally attached collection systems and strict standards for skin preparation, collection and storage of blood and components have reduced but not eliminated the risk of bacterial contamination. As bacteraemia may be part of acute or sub acute infections, strict donor selection is warranted. The longer the storage time, the greater is the number of organisms and amount of endotoxin present in the unit and associated with transfusion reactions. Importance of haemovigilance syst...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Jaisy Mathai Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Automated platelet collection using the latest apheresis devices in an Indian settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In a developing nation like India where there is a scarcity of resources and voluntary donors, provision of safe and good quality blood and its components is a huge challenge. The demand for platelets is increasing constantly due to better management of various patient categories, specifically hemato-oncological cases, where there is an increased demand of platelet transfusion. The use of apheresis single donor platelets (SDPs) has been attributed to increased gap between demand and supply of whole blood derived random donor platelets (RDPs). Moreover, the other benefits of SDPs such as decreased donor exposure a...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Prashant Agarwal, Anupam Verma Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Consensus and controversies in platelet transfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the current developments and challenges in optimizing platelet transfusion therapy. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Neelam Marwaha, R.R. Sharma Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Methods for evaluation of platelet functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There are a multitude of platelet function tests available, reflecting the complex nature of the platelet in haemostasis. No simple single test will ever cover all aspects of platelet function. Some tests focus on the aggregation of platelets, for example aggregometry, other on the swelling in response to hypotonic solutions, i.e. the well-known hypotonic shock response, or adhesion or coagulation and clot retraction, for example thromboelastography. In general there is a lack of clinical studies showing a predictive value of analysis of platelet concentrates. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Tomas L. Lindahl, Sofia Ramström Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Pooled platelet concentrates: An alternative to single donor apheresis platelets?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion the final products of LR–PC derived from whole blood or obtained by apheresis can be comparable, provided the critical steps of the processing method are identified and covered and the process is in control. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: R.N.I. Pietersz Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

The platelet storage lesionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The continuous increase in the demand for platelet transfusion has necessitated the need to establish standards for determining the quality of platelets during storage. Bacterial contamination of platelet products and deleterious changes in structure and function referred to as the platelet storage lesion (PSL), have restricted the platelet shelf life to 5days. The PSL and platelet health variables have been well studied and documented. The precise correlation between in vitro assays and in vivo platelet recovery and survival is yet to be established. This review presents an overview of the current understanding ...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Manisha Shrivastava Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Preparation, storage and quality control of platelet concentratesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Patients with thrombocytopaenia need transfusions of platelet concentrates to prevent or stop bleeding. A platelet transfusion should provide platelets with good functionality. The quality of platelet concentrates (PCs) is affected by the preparation method and the storage conditions including duration of storage, type of storage container, and storage solution (plasma or an additive solution). Different in vivo and in vitro techniques can be used to analyse PCs. Platelets can be collected by apheresis technique, and from whole blood using either the buffy-coat or the platelet-rich plasma method. PCs can be gamma...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Nahreen Tynngård Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

BiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Rajendra K. Chaudhary is an MD and DNB in pathology and has interests in immunohematology, platelet serology and clinical transfusion medicine. He is currently the Professor and Head of the Department of Transfusion Medicine at the Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) in Lucknow. Dr. Chaudhary is a member of the technical resource group for the National AIDS Control Organization in New Delhi and a member of the Post Graduate Board of the Medical Council of India (MCI) for Transfusion Medicine, where he is regarded as the country’s MCI expert in transfusion medicine. (Source: Transfusion...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Rajendra Chaudhary Tags: Guest Editor: Rajendra K. Chaudhary Source Type: journals

Utilization study of filgrastim (Neutromax®) during autologous haematopoietic precursor transplantation for myeloma and lymphoma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: To describe utilization of a biosimilar product containing filgrastim (Neutromax®), data of 414 myeloma or lymphoma patients subjected to autologous SCT between 1998 and 2007 were analyzed. Filgrastim was used for mobilization of progenitors (5days at 300μg/day) and for the recovery of neutropenia after transplantation (100μg/day, since day +5). In 2003, the excipient mannitol was replaced by sorbitol. A mean dose of 9.47×106CD34+cells/kg was infused; 100neutrophils/mm3 required 5-day treatment; 500neutrophils/mm3, 6days and 1000neutrophils/mm3, 7days. Neutromax® effect in SCT is similar to reports with othe...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Hugo H. Ferro, Mariana Juni, Ricardo Bello, Alejandro Vidal, Roberto A. Diez, Santiago Pavlovsky Tags: Submitted Papers Source Type: journals

The 2009 Canadian Apheresis Group and the Canadian Association of Apheresis Nurses Annual General MeetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Canadian Apheresis Group (CAG) and the Canadian Association of Apheresis Nurses (CAAN) held our 29th Annual General Meeting at the Chateau Cartier Hotel in Gatineau, Quebec, on May 1–3, 2009. Highlights of the meeting were the review of the 2008 data showing a total of 9834 plasma exchange procedures and 1888 stem cell collections from 29 reporting centres. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Gail Rock Tags: International Forum Source Type: journals

Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Volume 41.2 has an essential theme that is relevant to the scientific knowledge and fundamental practices of platelet transfusion. The theme section has been edited by Dr. Rajendra K. Chaudhary, Professor and Head of the Department of Transfusion Medicine at the Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) in Lucknow, India. Together with a team of leading practitioners, he shares information on procedures and outlines the serious complications and risks involved in platelet transfusion. Dr. Nahreen Tynngård of the Linköping University Hospital in Sweden discusses why ensuring good haemostatic func...
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Authors: Gail Rock Tags: Editorial Source Type: journals

Editorial board/Publication informationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - September 23, 2009 Category: Hematology Source Type: journals

Erratum to “Updates on pathogen inactivation of plasma using Theraflex methylene blue system” [Transfus. Apher. Sci. 38(3) (2008) 271–280]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors regret that a wrong table was included in the above paper. The correct of the paper is as follows. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Jerard Seghatchian, Wolfram H. Walker, Stefan Reichenberg Tags: Erratum Source Type: journals

Upcoming eventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Tags: Upcoming Events Source Type: journals

Post donation adverse reactions among Greek blood donors: A preliminary report based on phone interviewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies have investigated the occurrence of blood donation related reactions, but only few of them included a post donation observation showing an increased detection rate of blood donation adverse reactions (BDARs) . In Greece, research on this topic and its potential impact on blood donation process are issues that similarly deserve emphasis. The ever increasing transfusion demand, the decreased blood available and the misuse of blood can justify not only the urgent need for improving blood transfusion practice , but also can be addressed as convincing reasons to invest in a high quality blood donation process. ...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Emmanouil K. Symvoulakis, Evaggelia Lydaki, Irene Bolonaki, Irene Nikoloudi, Maria Kozyraki, Popi Fountouli Tags: Letter to the Editor Source Type: journals

Granulocyte transfusions for pediatric patients and the establishment of national treatment guidelines and donor registryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: G-CSF/dexamethasone stimulated donor derived granulocyte transfusion (GTX) has been shown in non-randomized studies to be a useful co-therapy in immune-compromised patients unresponsive to conventional antimicrobial treatments. Reports of GTX are however usually single institution adult experiences. Substantiated pediatric data, other than in neonates, is less common. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: H. Vrielink, B. Meijer, E. van ’t Ende, L.M. Ball, A. Brand, J.J. Zwaginga Tags: Guest Editor: Rainer Moog Source Type: journals

New agents for mobilizing peripheral blood stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Transplantation with bone marrow (BM) hematopoietic stem cells (HSC) has been used for curative therapy of hematologic diseases and inborn errors of metabolism for decades. More recently, alternative sources of HSC, particularly those induced to exit marrow and traffic to peripheral blood in response to external stimuli, have become the most widely used hematopoietic graft and show significant superiority to marrow HSC. Although a variety of agents can mobilize stem cells with different kinetics and efficiencies and these agents can be additive or synergistic when used in combination, currently G-CSF is the predo...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Hildegard T. Greinix, Nina Worel Tags: Guest Editor: Rainer Moog Source Type: journals

Comparison of different Lp (a) elimination techniques: A retrospective evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Lipoprotein (a), abbreviated Lp (a), is accepted as a potential selective or additional risk factor for premature atherosclerosis. Though it may be considered to be closely related to low density lipoprotein, so far attempts to keep it under control with diet or cholesterol lowering medications have failed. Thus, extracorporeal elimination is the only effective treatment approach for patients with premature atherosclerosis. As different techniques for differential elimination such as precipitation, adsorption and filtration exist, it appeared of interest for us to retrospectively evaluate adsorption and filtratio...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Helmut Borberg Tags: Guest Editor: Rainer Moog Source Type: journals

26 Years of LDL – Apheresis: A review of experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Since 1981, when LDL-Apheresis was introduced into the clinical routine at the University of Cologne as the first and so far only Apoprotein B specific LDL-cholesterol elimination technique, considerable experience has since then accumulated and has changed not only the operational technique but also extended the indications, the optimation of the target values, the introduction of supportive cholesterol lowering drug therapy, considerations of the potential pleiotropic mechanisms and the introduction of a quality control supported electronic data processing. Mild to moderate side effects range between 3% and 4.5...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: H. Borberg Tags: Guest Editor: Rainer Moog Source Type: journals

Isoagglutinin titre adsorption: Breaking the barrier in major AB0-incompatible organ transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Blood group AB0-incompatible live donor (LD) renal transplantation may provide a significant source of organs. AB0-incompatible LD renal transplantation can be accomplished using specific anti-A/B antibody (Ab) immunoadsorption (IA) and anti-CD20 monoclonal Ab (Rituximab®) treatment. One dose of anti-CD20 mAb (rituximab, 375mg/m2) is given for weeks pre-operatively. Recipients are pre-treated with 3–5 sessions of immunoadsorption, using A or B carbohydrate antigen specific columns, until their anti-A1/B RBC panel indirect antiglobulin test (IAT) titres are 8. Postoperative renal biopsies may yield positive C4d...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Benjamin Wilde, Frank Pietruck, Andreas Kribben, Oliver Witzke Tags: Guest Editor: Rainer Moog Source Type: journals

Improving the management of the blood supply through the use of Haemonetics’ MCS-8150 automated double red cell collection devicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Collecting additional red blood cell (RBC) units using the Haemonetics’ MCS-8150 double red blood cell (DRBC) capability can improve operational efficiencies, reduce the risk of blood shortages, and influence the type-distribution of RBC inventories. Portable, durable, and reliable, the MCS-8150 is suitable for both in-center and mobile collection situations. Donor acceptance is high and many report an enhanced donation experience making these DRBC donors more likely to donate again. The use of the MCS-8150 is a major contributor to our blood center’s collection growth, allowing us to transform from a major i...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Joseph Ridley Tags: Guest Editor: Rainer Moog Source Type: journals

Management of poor peripheral blood stem cell mobilization: Incidence, predictive factors, alternative strategies and outcome. A retrospective analysis on 2177 patients from three major Italian institutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: CD34+ peripheral blood hematopoietic stem cells (HSC) are usually collected following mobilization therapy accomplished by using growth factors (GF) such as rHuG-CSF or rHuGM-CSF with or without chemotherapy. A target dose of yielded CD34+ is usually prescribed by the attending physician depending on different protocols, which may include single or double transplantation. HSC collection usually is performed when at least 20 CD34+ HSC/μL are detected by means of flow cytometry. A cumulative dose of at least 2×106/Kg/bw CD34+ HSC has been considered as the threshold to allow a prompt and persistent hematopoietic ...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Paolo Perseghin, Elisabetta Terruzzi, Maria Dassi, Valentina Baldini, Matteo Parma, Paola Coluccia, Patrizia Accorsi, Giorgio Confalonieri, Luisa Tavecchia, Luisa Verga, Fernando Ravagnani, Antonio Iacone, E.M. Pogliani, Pietro Pioltelli Tags: Guest Editor: Rainer Moog Source Type: journals

WAA apheresis registry in the Czech Republic: Two centers experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In Czech Republic hemaphereses are performed in a broad scale of indications and now it is nearly 5years that data are registered in our two university centers. In 2004 we entered WAA registry because it meets the requirement to compare data with centers that do not perform aphereses for the same diagnosis. This comparison would certainly improve efficacy of the hemapheresis therapy even further. To enter WAA registry is easy, at no expense and without any problems. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Milan Bláha, Jan Pták, Jan Čáp, Věra Ceeová, Vladimír Mašín, Stanislav Filip, Martin Blažek Tags: Guest Editor: Rainer Moog Source Type: journals

Guest Editor BiographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Moog was born and raised in Ratingen, Germany. His post secondary education originated at Colonge Technical School and continued with his medical studies and doctoral thesis at the University of Essen, where he completed his full medical registration in 1986. He started his residency at the Institute for Transfusion Medicine in Essen and received his board certification in Transfusion Medicine in 1996. Dr. Moog’s earlier tenures were spent at the Department of Clinical Chemistry and Laboratory Medicine, University Clinic Essen in Germany and as a guest physician at the Immunohematology Service of the San Martino Hosp...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Rainer Moog Tags: Guest Editor: Rainer Moog Source Type: journals

2008 Congress of the ESFH in Düsseldorf, GermanyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 16th Congress of the Interdisciplinary European Society for Haemapheresis and Haemotherapy (ESFH) was held together with the German Society for Transfusion Medicine and Immunhaematology (DGTI) in Düsseldorf, Germany in September, 2008. The broad field of apheresis was presented in one state-of-the-art ESFH/DGTI symposium and one joint plenary on immunomodulation and therapeutic apheresis. Furthermore, four ESFH symposia were held and oral presentations with various topics from highly ranked submitted abstracts were given. Before the congress started the third postgraduate course of the ESFH was held with a morning ses...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Rainer Moog Tags: Guest Editor: Rainer Moog Source Type: journals

Treatment of refractory thrombotic thrombocytopenic purpura using multimodality therapy including splenectomy and cyclosporineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of refractory TTP that responded to multimodality immunosuppresive therapy that included splenectomy, intravenous gamma globulin, and cyclosporine after numerous plasma exchange treatments, steroids, rituximab and vincristine had failed to induce remission. Combining drugs that target T and B lymphocytes is a standard in organ transplantation and deserves more consideration in the treatment of severe and refractory autoimmune diseases such as TTP. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Kenar D. Jhaveri, Abby Scheuer, Jules Cohen, Bruce Gordon Tags: Submitted Papers Source Type: journals

Impact of allogeneic 2-RBC apheresis on iron stores of Brazilian blood donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: One limiting factor for automated two-red blood cells collections (2-RBC) is its potential iron depletion. We analyzed hematological parameters and iron balance before, two and four months after 2-RBC of 96 non-supplemented male donors. Four months after 2-RBC, ferritin level was significantly lower (P (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Alfredo Mendrone, Cyntia Araújo Arrais, César Almeida Neto, Sandra de Fátima Menocci Gualandro, Pedro Enrique Dorlhiac-Llacer, Dalton de Alencar Fischer Chamone, Ester Cerdeira Sabino Tags: Submitted Papers Source Type: journals

Autologous platelets and leukocytes can improve healing of infected high-energy soft tissue injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Despite advances in surgical techniques and pharmacology, healing of injury-associated soft tissue defects is frequently complicated by infections, which often requires a secondary intervention.Cytokines are important mediators of healing. Application of autologous platelet-rich plasma enriched in growth factors and antimicrobial proteins, known also as platelet–leukocyte rich plasma (PLRP), represents a novel approach to the treatment of soft tissue and bone healing disturbances. This case is the first report on the application of PLRP in an infected high-energy soft tissue injury and shows that the volume and...
Source: Transfusion and Apheresis Science - July 31, 2009 Category: Hematology Authors: Agata Cieslik-Bielecka, Tomasz Bielecki, Tadeusz S. Gazdzik, Jerzy Arendt, Wojciech Król, Tomasz Szczepanski Tags: Submitted Papers Source Type: journals