Will proteomics design next-generation management of cardiovascular diseases?
Publication date: Available online 18 February 2015 Source:Translational Proteomics Author(s): P. Fontana , J.-L. Reny (Source: Translational Proteomics)
Source: Translational Proteomics - February 19, 2015 Category: Biomedical Science Source Type: research

Plasma proteomics to identify biomarkers – application to cardiovascular diseases
Publication date: Available online 12 January 2015 Source:Translational Proteomics Author(s): Hans Christian Beck , Martin Overgaard , Lars Melholt Rasmussen There is an unmet need for new cardiovascular biomarkers. Despite this only few biomarkers for the diagnosis or screening of cardiovascular diseases have been implemented in the clinic. Thousands of proteins can be analysed in plasma by mass spectrometry-based proteomics technologies. Therefore, this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challe...
Source: Translational Proteomics - January 13, 2015 Category: Biomedical Science Source Type: research

Plasma proteomics to identify biomarkers − application to cardiovascular diseases
Publication date: Available online 12 January 2015 Source:Translational Proteomics Author(s): Hans Christian Beck , Martin Overgaard , Lars Melholt Rasmussen There is an unmet need for new cardiovascular biomarkers. Despite this only few biomarkers for the diagnosis or screening of cardiovascular diseases have been implemented in the clinic. Thousands of proteins can be analysed in plasma by mass spectrometry-based proteomics technologies. Therefore, this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challe...
Source: Translational Proteomics - January 12, 2015 Category: Biomedical Science Source Type: research

Dissecting the proteome of lipoproteins: New biomarkers for cardiovascular diseases?
Publication date: Available online 5 January 2015 Source:Translational Proteomics Author(s): Anne von Zychlinski , Torsten Kleffmann Proteomics has proven to be a powerful tool for the characterization of lipoproteins and has provided important insights into the biochemistry and pathophysiology of various lipoprotein classes. It has significantly contributed to the way we now see lipoproteins as complex particles not only involved in lipid transport and exchange, but also in processes such as immune response, inflammation and wound healing. Ongoing proteomics research is focussing on the identification of new candida...
Source: Translational Proteomics - January 8, 2015 Category: Biomedical Science Source Type: research

Dissecting the proteome of lipoproteins: New biomarkers for cardiovascular diseases? “Your article is registered as belonging to the Special Issue/Collection entitled “Cardiovascular Disorders”. If this is NOT correct and your article is a regular item or belongs to a different Special Issue please contact v.rawat@elsevier.com immediately prior to returning your corrections.”-->
Publication date: Available online 5 January 2015 Source:Translational Proteomics Author(s): Anne von Zychlinski , Torsten Kleffmann Proteomics has proven to be a powerful tool for the characterization of lipoproteins and has provided important insights into the biochemistry and pathophysiology of various lipoprotein classes. It has significantly contributed to the way we now see lipoproteins as complex particles not only involved in lipid transport and exchange, but also in processes such as immune response, inflammation and wound healing. Ongoing proteomics research is focussing on the identification of new candida...
Source: Translational Proteomics - January 5, 2015 Category: Biomedical Science Source Type: research

Neuroproteomics 101
Publication date: June 2014 Source:Translational Proteomics, Volume 3 Author(s): Kevin K.W. Wang , Joan Montaner (Source: Translational Proteomics)
Source: Translational Proteomics - December 17, 2014 Category: Biomedical Science Source Type: research

Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense
Publication date: Available online 15 December 2014 Source:Translational Proteomics Author(s): Natalia Tiberti , Veerle Lejon , Dieudonné Mumba Ngoyi , Enock Matovu , John Enyaru , Nadia Walter , Catherine Fouda , Pascal Lutumba , Krister Kristensson , Sylvie Bisser , Joseph Mathu Ndung’u , Philippe Büscher , Jean-Charles Sanchez The host central nervous system (CNS) response to infection with Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense parasites, the causing agent of human African trypanosomiasis (HAT), is a poorly explored area. The two parasites are responsible for respectively a chron...
Source: Translational Proteomics - December 15, 2014 Category: Biomedical Science Source Type: research

Advances in mass spectrometry-based technologies to direct personalized medicine in ovarian cancer
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Felix Leung , Natasha Musrap , Eleftherios P. Diamandis , Vathany Kulasingam Ovarian cancer is the most lethal gynaecological malignancy in North America and remains one of the most difficult cancers to manage. Although the 5-year survival rates are high when the disease is diagnosed early, this decreases exponentially in late-stage diagnoses and due to the current lack of screening methods, ovarian cancer is often diagnosed in its later stages when the cancer has progressed considerably. To exacerbate this, ovarian cancer patients...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Mass spectrometry based translational neuroinjury proteomics
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Ahmed Moghieb , Manasi Mangaonkar , Kevin K.W. Wang Neuroinjury, including traumatic brain injury, ischemic and hemorrhagic stroke (intracerebral hemorrhage), subarachnoid hemorrhage and spinal cord injury, collectively is a significant biomedical problem worldwide. Yet there are few therapeutic options available. We submit that mass spectrometry-based proteomic approach can have a potentially high impact in biomarkers discovery and drug target identification for various forms of CNS injury. This review provides an outline of the mo...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Blood microvesicles: From proteomics to physiology
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Jean-Daniel Tissot , Giorgia Canellini , Olivier Rubin , Anne Angelillo-Scherrer , Julien Delobel , Michel Prudent , Niels Lion Phospholipid vesicles of less than 1μm are present in blood in physiological state and their concentration may vary under pathological conditions. Various names such as exosomes (EXS) and microparticles (MPS) have been used to designate these extracellular vesicles (EVS). Although EXs and MPS possibly arise from separate mechanisms, they share numerous similarities representing a challenge for their pu...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Unraveling modulators of platelet reactivity in cardiovascular patients using omics strategies: Towards a network biology paradigm
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Anne Zufferey , Mark Ibberson , Jean-Luc Reny , Ioannis Xenarios , Jean-Charles Sanchez , Pierre Fontana Platelets play an important role in the pathogenesis and the ischemic complications of atherosclerosis. Platelets may be activated by several different agonists, promoting the release of their granule contents and subsequent aggregation and thrombus formation; this leads to ischemic events such as myocardial infarction or stroke. Aspirin, the most popular antiplatelet agent, is a cornerstone in the treatment and prevention of ...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Translation of human African trypanosomiasis biomarkers towards field application
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Natalia Tiberti , Alexandre Hainard , Jean-Charles Sanchez Sleeping sickness is a neglected tropical disease affecting rural communities in sub-Saharan Africa. The reduction in the number of reported cases in recent years indicates that disease transmission is under control. However, many aspects of patient management still need to be improved. Undiagnosed patients or inappropriate treatment due to an incorrect determination of the disease stage could in fact lead to its re-emergence. There is thus a strong need for new diagnostic a...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): F. Topf , D. Schvartz , P. Gaudet , F. Priego-Capote , A. Zufferey , N. Turck , P.-A. Binz , P. Fontana , A. Wiederkehr , F. Finamore , I. Xenarios , D. Goodlett , M. Kussmann , P. Bergsten , J.-C. Sanchez Type 2 diabetes is a worldwide disease reaching epidemic dimensions. The rapid progression of the disease urgently calls for both a broader and deeper understanding of its pathophysiology. In line with this statement, the Human Diabetes Proteome Project (HDPP) was officially launched at the 11th HUPO meeting in Boston,...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

PanelomiX: A threshold-based algorithm to create panels of biomarkers
In conclusion, the PanelomiX toolbox combines biomarkers and evaluates the performance of panels to classify patients better than single markers or other classifiers. The ICBT algorithm proved to be an efficient classifier, the results of which can easily be interpreted. Graphical abstract (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Is clinical proteomics heading towards to “bench to bedside”?
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research