Targeting the Devil: Strategies Against Cancer-Associated Fibroblasts in Colorectal Cancer
Cancer-associated fibroblasts (CAFs), as significant constituents of the tumor microenvironment (TME), play a pivotal role in the progression of cancers, including colorectal cancer (CRC). In this comprehensive review, we presented the origin and activation mechanisms of CAFs in CRC, elaborating on how CAFs drive tumor advancement through their interactions with CRC cells, immune cells, vascular endothelial cells, and the extracellular matrix within the tumor microenvironment. We systematically outline the intricate web of interactions among CAFs, tumor cells, and other TME components, and based on this complex interplay, ...
Source: Translational Research - April 11, 2024 Category: Research Authors: Yuting Chen, Zhiyong Liang, Maode Lai Source Type: research
Exosomal Tenascin-C Primes Macrophage Pyroptosis Amplifying Aberrant Inflammation during Sepsis-Induced Acute Lung Injury
Sepsis-induced acute lung injury (ALI) is a serious complication of sepsis and the predominant cause of death. Exosomes released by lung tissue cells critically influence the progression of ALI during sepsis by modulating the inflammatory microenvironment. However, the molecular mechanisms by which exosome-mediated intercellular signaling exacerbates ALI in septic infection remain undefined. Our study found increased levels of exosomal Tenascin-C (TNC) in the plasma of both patients and mice with ALI, showing a strong association with disease progression. (Source: Translational Research)
Source: Translational Research - April 9, 2024 Category: Research Authors: Ting Gong, Xuedi Zhang, Xiaolei Liu, Yinfeng Ye, Zhiyuan Tian, Shuang Yin, Min Zhang, Jing Tang, Youtan Liu Source Type: research
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Source: Translational Research - April 7, 2024 Category: Research Source Type: research
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Source: Translational Research - April 7, 2024 Category: Research Source Type: research
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Source: Translational Research - April 7, 2024 Category: Research Source Type: research
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Source: Translational Research - April 7, 2024 Category: Research Source Type: research
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Source: Translational Research - April 7, 2024 Category: Research Source Type: research
Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy
Peripheral neuropathy (PN) is a severe and frequent complication of obesity, prediabetes, and type 2 diabetes characterized by progressive distal-to-proximal peripheral nerve degeneration. However, a comprehensive understanding of the mechanisms underlying PN, and whether these mechanisms change during PN progression, is currently lacking. Here, gene expression data were obtained from distal (sciatic nerve; SCN) and proximal (dorsal root ganglia; DRG) injury sites of a high-fat diet (HFD)-induced mouse model of obesity/prediabetes at early and late disease stages. (Source: Translational Research)
Source: Translational Research - March 29, 2024 Category: Research Authors: St éphanie A. Eid, Sarah E. Elzinga, Kai Guo, Lucy M. Hinder, John M. Hayes, Crystal M. Pacut, Emily J. Koubek, Junguk Hur, Eva L. Feldman Source Type: research
Sex-Related Differences in SIRT3-Mediated Mitochondrial Dynamics in Renal Ischemia/Reperfusion Injury
The prevalence of renal ischemia/reperfusion injury (IRI) in premenopausal women is considerably lower than that in age-matched men. This suggests that sex-related differences in mitochondrial function and homeostasis may contribute to sexual dimorphism in renal injury, though the mechanism remains unclear. Mouse model of unilateral left renal IRI with contralateral kidney enucleation, Ovariectomy in female mice, and a human embryonic kidney (HEK) cell model of hypoxia-reoxygenation were used to study how estrogen affects the sexual dimorphism of renal IRI through SIRT3 in vitro and in vivo, respectively. (Source: Translational Research)
Source: Translational Research - March 29, 2024 Category: Research Authors: Hanlin Yao, Hongchao Zhao, Yang Du, Ye Zhang, Yanze Li, Hengcheng Zhu Source Type: research
A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein
The transcribed ultraconserved region (T-UCR) belongs to a new type of lncRNAs that are conserved in homologous regions of the rat, mouse and human genomes. A lot of research has reported that differential expression of T-UCRs can influence the development of various cancers, revealing the ability of T-UCRs as new therapeutic targets or potential cancer biomarkers. Most studies on the molecular mechanisms of T-UCRs in cancer have focused on ceRNA regulatory networks and interactions with target proteins, but the present study reveals an innovative dual-targeted regulatory approach in which T-UCRs bind directly to mRNAs and...
Source: Translational Research - March 27, 2024 Category: Research Authors: Sixian Chen, Qingyun Zhao, Ruirui Zhang, Jungang Liu, Wenyi Peng, Haotian Xu, Xiaofei Li, Xin Wang, Shuilian Wu, Gang Li, Aruo Nan Source Type: research
Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression
Post-ischemic angiogenesis is critical for perfusion recovery and tissue repair. ELABELA (ELA) plays an essential role in embryonic heart development and vasculogenesis. However, the mechanism of ELA on post-ischemic angiogenesis is poorly characterized. (Source: Translational Research)
Source: Translational Research - March 26, 2024 Category: Research Authors: Jia-Yu Peng, Xiao Fu, Xue-Yang Luo, Fang Liu, Bing Zhang, Bin Zhou, Kun Sun, Alex F. Chen Source Type: research
The LPS-inactivating enzyme acyloxyacyl hydrolase protects the brain from experimental stroke
Blood-brain-barrier (BBB) disruption is a pathological hallmark of ischemic stroke, and inflammation occurring at the BBB contributes to the pathogenesis of ischemic brain injury. Lipopolysaccharide (LPS), a cell wall component of Gram-negative bacteria, is elevated in patients with acute stroke. The activity of LPS is controlled by acyloxyacyl hydrolase (AOAH), a host enzyme that deacylates LPS to inactivated forms. However, whether AOAH influences the pathogenesis of ischemic stroke remain elusive. (Source: Translational Research)
Source: Translational Research - March 22, 2024 Category: Research Authors: Yuanbo Zhu, Yue Hu, Zhongwang Liu, Luping Chang, Xue Geng, Xuhui Yin, Bing-Qiao Zhao, Wenying Fan Source Type: research
Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Cisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. (Source: Translational Research)
Source: Translational Research - March 16, 2024 Category: Research Authors: Pratikshya Sa, Priya Singh, Sudhakar Panda, Rajeeb K. Swain, Rupesh Dash, Sanjeeb Kumar Sahoo Source Type: research
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy
In this study, we aimed to investigate the effects and the underlying mechanism of XBP1 in the progression of hepatic I/R injury. Hepatocyte-specific XBP1 knockout mice, multiple viral delivery systems and specific pharmacological inhibitors were applied in vivo in a partial hepatic I/R injury mouse model and in vitro in a cell model of hypoxia-reoxygenation (H/R) injury. (Source: Translational Research)
Source: Translational Research - March 15, 2024 Category: Research Authors: Baicheng Kuang, Mengqin Wang, Hao Yan, Qin Jiang, Zhiheng Wang, Haiqiang Ni, Shuaiheng Hou, Xuan Peng, Shiqi Gu, Yuanyuan Zhao, Tongwen Ou, Nianqiao Gong Source Type: research
