Apolipoprotein A ‐Ib as a biomarker of focal segmental glomerulosclerosis recurrence after kidney transplantation: diagnostic performance and assessment of its prognostic value – a multi‐centre cohort study
SummaryRecurrence of idiopathic focal segmental glomerulosclerosis (FSGS) is a serious complication after kidney transplantation. FSGS relapse is suspected by a sudden increase in proteinuria but there is not an accurate noninvasive diagnostic tool to confirm this entity or to detect patients at risk. We aimed to validate the diagnostic performance of ApoA ‐Ib to detect FSGS relapses by measuring urinary ApoA‐Ib in a retrospective cohort of 61 kidney transplanted patients (37 FSGS and 24 non‐FSGS). In addition, to assess the ApoA‐Ib predictive ability, ApoA‐Ib was measured periodically in a prospective cohort of ...
Source: Transplant International - November 28, 2018 Category: Transplant Surgery Authors: Nat àlia Puig‐Gay, Conxita Jacobs‐Cacha, Joana Sellarès, Lluís Guirado, Francisco González Roncero, Carlos Jiménez, Sofía Zárraga, Javier Paul, Ricardo Lauzurica, Ángel Alonso, Ana Fernández, Isabel Beneyto, Auxiliadora Mazuecos, Tags: Original Article Source Type: research

Vascularized composite allotransplantation – a Council of Europe position paper
SummaryAfter more than 120 hand ‐upper extremity and 37 face transplant procedures performed worldwide, vascularized composite allotransplantation (VCA) now falls under the scope of organ transplant legislation in Europe and the United States. While in the USA, VCA has been considered as standard care since 2014, VCA in Europe i s still performed through clinical research trials, except in United Kingdom. However, after two decades of favourable experience with upper extremity transplantation (UET), professionals in Europe are proposing hand allotransplantation as “controlled standard” care, as opposed to face transp...
Source: Transplant International - November 26, 2018 Category: Transplant Surgery Authors: Marie Thuong, Palmina Petruzzo, Luis Landin, Beatriz Mahillo, Simon Kay, Sylvie Testelin, Jerzy Jablecki, Karim Laouabdia ‐Sellami, Marta L. Fraga, Beatriz Dominguez‐Gil Tags: Review Source Type: research

Assessment of simple indices based on a single fasting blood sample as a tool to estimate beta ‐cell function after total pancreatectomy with islet autotransplantation – a prospective study
SummaryWe investigated six indices based on a single fasting blood sample for evaluation of the beta ‐cell function after total pancreatectomy with islet autotransplantation (TP‐IAT). The Secretory Unit of Islet Transplant Objects (SUITO), transplant estimated function (TEF), homeostasis model assessment (HOMA‐2B%), C‐peptide/glucose ratio (CP/G), C‐peptide/glucose creatinine ratio (CP/GC r) and BETA‐2 score were compared against a 90‐min serum glucose level, weighted mean C‐peptide in mixed meal tolerance test (MMTT), beta score and the Igls score adjusted for islet function in the setting of IAT. We analy...
Source: Transplant International - November 26, 2018 Category: Transplant Surgery Authors: Justyna E. Go łębiewska, Piotr J. Bachul, Natalie Fillman, Lindsay Basto, Mark R. Kijek, Karolina Gołąb, Ling‐jia Wang, Martin Tibudan, Celeste Thomas, Alicja Dębska‐Ślizień, Andres Gelrud, Jeffrey B. Matthews, J Michael Millis, Jo Tags: Original Article Source Type: research

Inhaled nitric oxide dependency at the end of double ‐lung transplantation: A boosted propensity score cohort analysis
ConclusionsiNO dependency is an early marker of a poor prognosis following DLT.This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - November 17, 2018 Category: Transplant Surgery Authors: Julien Fessler, Mathieu Godement, Romain Pirracchio, Jean ‐Yves Marandon, Jacques Thes, Edouard Sage, Antoine Roux, François Parquin, Charles Cerf, Marc Fischler, Morgan Le Guen Tags: Original Article Source Type: research

Effects of remote ischaemic preconditioning on intraportal islet transplantation in a rat model
SummaryRemote ischaemic preconditioning (RIPC), which is the intermittent interruption of blood flow to a site distant from the target organ, is known to improve solid organ resistance to ischaemia ‐reperfusion injury. This procedure could be of interest in islet transplantation to mitigate hypoxia‐related loss of islet mass after isolation and transplantation. Islets isolated from control or RIPC donors were analyzed for yield, metabolic activity, gene expression and high mobility group b ox‐1 (HMGB1) content. Syngeneic marginal mass transplantation was performed in four streptozotocin‐induced diabetic groups: con...
Source: Transplant International - November 16, 2018 Category: Transplant Surgery Authors: Vaihere Delaune, St éphanie Lacotte, Quentin Gex, Florence Slits, Arianna Kahler‐Quesada, Vanessa Lavallard, Andrea Peloso, Lorenzo A. Orci, Thierry Berney, Christian Toso Tags: Original Article Source Type: research

Increasing pre ‐transplant confidence and safety for use of questionable donor lungs with ex‐situ assessment and reconditioning
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - November 14, 2018 Category: Transplant Surgery Authors: Dirk Van Raemdonck, Arne Neyrinck Tags: Invited Commentary Source Type: research

Outcome ‐dependent geographic and individual variations in the access to renal transplantation in incident dialyzed patients: a French nationwide cohort study
This study investigated geographic variations of access to renal transplantation using three outcomes (access to the transplant waiting list, access to renal transplantation after waitlisting and access to renal transplantation after dialysis start). Associations of patient ‐related and regional variables with the studied outcomes were assessed using a Cox shared frailty model and a Fine and Gray model. At the study endpoint (December 31, 2015), 26.3% of all 18‐90‐year‐old patients who started dialysis in the 22 mainland and 4 overseas French regions in 2012 (n =9312) were waitlisted and 15.1% received a kidney tra...
Source: Transplant International - November 14, 2018 Category: Transplant Surgery Authors: Ad élaïde Pladys, Camille Morival, Cécile Couchoud, Christian Jacquelinet, Emmanuelle Laurain, Sylvie Merle, Cécile Vigneau, Sahar Bayat, The REIN registry Tags: Original Article Source Type: research

Weekend effect on early allograft outcome after kidney transplantation ‐ a multi‐centre cohort study
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - November 14, 2018 Category: Transplant Surgery Authors: Wai H Lim, Patrick T Coates, Graeme R Russ, Christine Russell, Bulang He, Bryon Jaques, Henry Pleass, Jeremy R Chapman, Germaine Wong Tags: Original Article Source Type: research

Urinary proteomics: fancy gadgetry or a clinically useful diagnostic instrument? The end ‐user's perspective
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - November 13, 2018 Category: Transplant Surgery Authors: George S. Reusz Tags: Invited Commentary Source Type: research

Evaluation of Pancreatic Duct Cannulation Methods for Human Islet Isolation
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - November 12, 2018 Category: Transplant Surgery Authors: Yoshitaro Shindo, Marlon F. Levy, Mazhar A. Kanak Tags: Letter to the Editor Source Type: research

Apolipoprotein A ‐Ib as a biomarker of FSGS recurrence after kidney transplantation: Diagnostic performance and assessment of its prognostic value ‐ a multi‐centre cohort study
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - November 8, 2018 Category: Transplant Surgery Authors: Nat àlia Puig‐Gay, Conxita Jacobs‐Cacha, Joana Sellarès, Lluís Guirado, Francisco González Roncero, Carlos Jiménez, Sofía Zárraga, Javier Paul, Ricardo Lauzurica, Alonso Ángel, Ana Fernández, Isabel Beneyto, Auxiliadora Mazuecos, Tags: Original Article Source Type: research

Pre ‐ and postdonation kidney function in donors of a kidney paired donation with unique criteria for donor glomerular filtration rate – a longitudinal cohort analysis
SummaryBaseline predonation estimated GFR (eGFR) appears to predict the risk of postdonation chronic kidney disease in live donors. New KIDGO guidelines recommend an eGFR ≥90 ml/min/1.73 m2 as an acceptable level of glomerular filtration rate (GFR) for kidney donation. In the Australian Paired Kidney Exchange (AKX) program, all donors with a raw measured GFR (mGFR) ≥80 ml/min are deemed suitable for donation, but the significance of this selection indicator is unclear. We analysed the first 129 live donors in the AKX program with at least 1‐year follow‐up linking records in the AKX database and ANZDATA. There were ...
Source: Transplant International - November 8, 2018 Category: Transplant Surgery Authors: Jenny H. C. Chen, Peter Hughes, Claudia Woodroffe, Paolo Ferrari Tags: Original Article Source Type: research

Microvascular inflammation in renal allograft biopsies assessed by endothelial and leukocyte co ‐immunostain: a retrospective study on reproducibility and clinical/prognostic correlates
Transplant International,Volume 0, Issue ja, -Not available-. (Source: Transplant International)
Source: Transplant International - November 5, 2018 Category: Transplant Surgery Authors: Marco Delsante, Umberto Maggiore, Jonathan Levi, David E Kleiner, Annette M Jackson, Lois J Arend, Stephen M. Hewitt, Naima Carter ‐Monroe, Serena M Bagnasco, Avi Z Rosenberg Source Type: research

Issue Information
Transplant International,Volume 31, Issue 12, Page 1289-1292, December 2018. (Source: Transplant International)
Source: Transplant International - November 5, 2018 Category: Transplant Surgery Source Type: research

The relevance of donor satisfaction after living kidney donation —a plea for a routine psychosocial follow‐up
Transplant International,Volume 31, Issue 12, Page 1330-1331, December 2018. (Source: Transplant International)
Source: Transplant International - November 5, 2018 Category: Transplant Surgery Authors: Sylvia Kroencke Source Type: research