Female sex as a biological variable: A review on younger patients with acute coronary syndrome
Although acute coronary syndrome (ACS) mainly occurs in individuals>60 years, younger adults can be affected as well. Women continue to be at higher risk of 30-day mortality after ST-segment elevation myocardial infarction (STEMI) even in the current era of percutaneous coronary intervention (PCI). Importantly, the excess mortality among women is only significant at younger ages. Previous work has suggested that the reason for the differences in outcome is likely multifactorial and may partially be explained by some of the following factors: atypical presentation, delayed presentation, under recognition of STEMI at initial...
Source: Trends in Cardiovascular Medicine - June 12, 2018 Category: Cardiology Authors: Raffaele Bugiardini, Olivia Manfrini, Edina Cenko Source Type: research
Gout and arrhythmias: in search for causation beyond association
Gout is a systemic disease, characterized by the formation and deposition of crystals in tissues (mainly in and around the joints) of individuals with elevated serum uric acid levels. Lately, a considerable number of reports relating elevated uric acid and/or gout with rhythm disorders, such as atrial fibrillation, have been published. This review summarizes evidence linking common arrhythmias and hyperuricemia/gout and discusses questions or controversies that surround it. Overall, existing evidence may not be overwhelming, but strongly suggests a positive correlation between uric acid levels and common rhythm disorders. ...
Source: Trends in Cardiovascular Medicine - June 12, 2018 Category: Cardiology Authors: Georgios Giannopoulos, Christos Angelidis, Spyridon Deftereos Source Type: research
Update on Cardio-Oncology: Novel Cancer Therapeutics and Associated Cardiotoxicities.
There have been significant advances in the field of oncology leading to improved survival as a result of novel targeted and immunotherapies. Despite these improved outcomes, there is increased recognition of cardiotoxicities associated with these therapies that can lead to significant morbidity and mortality. As such, the field of cardio-oncology has seen significant growth over the last several years. In this review, we discuss recent advances in the field of cardio-oncology and provide a detailed discussion of the cardiovascular complications associated with novel cancer therapeutics including tyrosine kinase inhibitors...
Source: Trends in Cardiovascular Medicine - June 8, 2018 Category: Cardiology Authors: Avirup Guha, Merna Armanious, Michael G. Fradley Source Type: research
Naming the misfits - MINOCA, ACSNNOCA, and the rest of the family,
Naming and categorization are essential prerequisites in scientific medicine. Ideally, these practices facilitate the understanding, diagnosis, and treatment of a disease process. The relationship is bidirectional; scientific advances improve the precision and utility of names, such as shifting “Q-wave myocardial infarction” to “ST-elevation myocardial infarction.” In cardiology, we have been fortunate to witness many scientifically meaningful name transitions over the past few decades. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 5, 2018 Category: Cardiology Authors: Radmila Lyubarova, Joshua Schulman-Marcus Source Type: research
Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis – novel insights and future directions in diagnosis and therapy
We provide an up-to-date overview of current topics surrounding oxidized low-density lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at risk of cardiovascular disease and atherosclerotic plaques with unfavorable characteristics. We discuss the potential of oxLDL and anti-oxLDL antibodies as serum biomarkers of cardiovascular disease and emerging studies examining the targeting of arterial oxLDL for imaging and therapeutic delivery. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 4, 2018 Category: Cardiology Authors: Adam Hartley, Haskard Dorian, Ramzi Khamis Source Type: research
Perspectives on the Relation of Blood Pressure and Cognition in the Elderly
The relationship of blood pressure to cognition in the elderly is a poorly understood topic. Many questions exist such as does treatment of hypertension prevent cognitive decline, the optimal timing of intervention and selecting the appropriate agent. In this review we will explore recent epidemiologic data and clinical trials addressing hypertension and cognition, review pathophysiology of chronic hypertension and effects of brain function, discuss the timing of intervention and finally review opportunities for future research. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - June 2, 2018 Category: Cardiology Authors: Christopher Goshgarian, Philip B. Gorelick Source Type: research
Two Faces of Janus: The Complexities of Coronary Artery Calcium Density and Distribution
Dr. Ferencik was supported by a grant from the American Heart Association: Fellow to Faculty Award 13FTF16450001 (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 29, 2018 Category: Cardiology Authors: Maros Ferencik, James E. Udelson Source Type: research
Sudden cardiac death prediction in the general population and among patients with left ventricular ejection fractions greater than 40%
Sudden cardiac death (SCD) refers to an unexpected and sudden death from cardiovascular cause in a person with or without preexisting heart disease [1,2]. SCD is a major public health problem with reported annual incidence rates ranging from 50 to 100 per 100,000 persons in the general population [3,4]. This corresponds to 7-20% of all deaths and ≈50% of cardiovascular deaths [3–5]. As most sudden cardiac arrests are fatal despite resuscitation attempts and occurs unexpectedly, prevention is inherently difficult [5,6]. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 29, 2018 Category: Cardiology Authors: Thomas Hadberg Lynge, Bo Gregers Winkel, Jacob Tfelt-Hansen Source Type: research
A systematic view on E3 ligase Ring TRIMmers with a focus on cardiac function and disease
Ubiquitination, a post-translational modification via ubiquitin-proteasome-system, is one of the vital cellular processes involved in intracellular signaling, cell death, transcriptional control, etc. Importantly, it prevents the aggregation of non-functional, misfolded or unfolded, potentially toxic proteins to maintain cellular protein homeostasis. Ubiquitination is accomplished by the concerted action of three enzymatic steps involving E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 28, 2018 Category: Cardiology Authors: Ankush Borlepawar, Norbert Frey, Ashraf Yusuf Rangrez Source Type: research
Acute Coronary Syndromes in Patients with Angiographically Normal or Near Normal (Non-Obstructive) Coronary Arteries
Patients with acute coronary syndrome (ACS) with normal or near-normal (non-obstructive) coronary arteries (ACSNNOCA) constitute an important, albeit heterogeneous, patient subset of younger patients, more commonly females, who may have lower risk of cardiovascular events compared to patients with obstructive coronary artery disease; however this risk remains substantial, hence needing further investigation to identify the underlying cause and devise a proper therapeutic strategy. A diagnostic algorithm starts during coronary angiography with some essential additional diagnostic steps, such as a left ventricular angiogram ...
Source: Trends in Cardiovascular Medicine - May 23, 2018 Category: Cardiology Authors: Antonis S. Manolis, Antonis A. Manolis, Theodora A. Manolis, Helen Melita Source Type: research
Pushing preeclampsia back to pre-preeclampsia
How to push preeclampsia one step backward (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 21, 2018 Category: Cardiology Authors: Friedrich C. Luft, Ralf Dechend Source Type: research
Technology to Treat Heart Failure: Friend or Foe?
Disclosures (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 19, 2018 Category: Cardiology Authors: Sitaramesh Emani Source Type: research
Vasovagal syncope –role of closed loop stimulation pacing
The benefit of conventional pacing in vasovagal syncope remains controversial and is currently recommended for patients with recurrent syncope and documented asystole. In the last two decades, a growing body of evidence has emerged supporting the use of a new sensing technique called closed loop stimulation or CLS, to treat refractory vasovagal syncope. CLS uses a sensing algorithm that can detect variation in cardiac contractility and respond to drop in blood pressure by increasing the heart rate. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 17, 2018 Category: Cardiology Authors: Mohammed Ruzieh, Blair P. Grubb Source Type: research
Reversal of Coronary Atherosclerosis: Role of Life Style and Medical Management
Atherosclerotic coronary artery disease continues to be a major global health burden in developing and developed nations. Newer imaging techniques afford an accurate assessment of plaque burden and characteristics as well as the effects of treatment. Lifestyle interventions and pharmacotherapy remains the mainstay of non-interventional treatment of coronary atherosclerosis, with reversal seen in many studies. In addition, control of modifiable risk factors can be beneficial. As a better understanding of atherosclerosis pathophysiology is achieved, new therapeutic targets and combination therapies may join the armamentarium...
Source: Trends in Cardiovascular Medicine - May 17, 2018 Category: Cardiology Authors: Christine Parsons, Pradyumna Agasthi, Farouk Mookadam, Reza Arsanjani Source Type: research
Vasovagal syncope - role of closed loop stimulation pacing
The benefit of conventional pacing in vasovagal syncope remains controversial and is currently recommended for patients with recurrent syncope and documented asystole. In the last two decades, a growing body of evidence has emerged supporting the use of a new sensing technique called closed loop stimulation or CLS, to treat refractory vasovagal syncope. CLS uses a sensing algorithm that can detect variation in cardiac contractility and respond to drop in blood pressure by increasing the heart rate. (Source: Trends in Cardiovascular Medicine)
Source: Trends in Cardiovascular Medicine - May 17, 2018 Category: Cardiology Authors: Mohammed Ruzieh, Blair P. Grubb Source Type: research
