Harnessing gastrointestinal organoids for cancer therapy
Trends Mol Med. 2024 Apr 13:S1471-4914(24)00065-0. doi: 10.1016/j.molmed.2024.03.010. Online ahead of print.ABSTRACTGastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.PMID:38616435 | DOI:10.1016/j.molmed.2024.03.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Gunter Maubach Michael Naumann Source Type: research
Eating disorders - enemies of the body and mind
Trends Mol Med. 2024 Apr;30(4):295-296. doi: 10.1016/j.molmed.2024.02.014.NO ABSTRACTPMID:38604129 | DOI:10.1016/j.molmed.2024.02.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Aliki Perdikari Source Type: research
Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
Eating disorders - enemies of the body and mind
Trends Mol Med. 2024 Apr;30(4):295-296. doi: 10.1016/j.molmed.2024.02.014.NO ABSTRACTPMID:38604129 | DOI:10.1016/j.molmed.2024.02.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Aliki Perdikari Source Type: research
Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
Eating disorders - enemies of the body and mind
Trends Mol Med. 2024 Apr;30(4):295-296. doi: 10.1016/j.molmed.2024.02.014.NO ABSTRACTPMID:38604129 | DOI:10.1016/j.molmed.2024.02.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Aliki Perdikari Source Type: research
Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
Eating disorders - enemies of the body and mind
Trends Mol Med. 2024 Apr;30(4):295-296. doi: 10.1016/j.molmed.2024.02.014.NO ABSTRACTPMID:38604129 | DOI:10.1016/j.molmed.2024.02.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Aliki Perdikari Source Type: research
Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
Targeting connexins: possible game changer in managing neuropathic pain?
Trends Mol Med. 2024 Apr 8:S1471-4914(24)00064-9. doi: 10.1016/j.molmed.2024.03.009. Online ahead of print.ABSTRACTNeuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in neuropathic pain along with reactive gliosis, contributing to neuronal hypersensitivity and hyperexcitability. In this review, we delve into the current understan...
Source: Trends in Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Yixun Su Alexei Verkhratsky Chenju Yi Source Type: research
SOX17: escape route from immune destruction in early CRC
Trends Mol Med. 2024 Apr 9:S1471-4914(24)00089-3. doi: 10.1016/j.molmed.2024.04.001. Online ahead of print.ABSTRACTIn a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5- (LGR5-) tumor cells, which suppress interferon gamma (IF...
Source: Trends in Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Kostas A Papavassiliou Christos Adamopoulos Athanasios G Papavassiliou Source Type: research
Targeting connexins: possible game changer in managing neuropathic pain?
Trends Mol Med. 2024 Apr 8:S1471-4914(24)00064-9. doi: 10.1016/j.molmed.2024.03.009. Online ahead of print.ABSTRACTNeuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in neuropathic pain along with reactive gliosis, contributing to neuronal hypersensitivity and hyperexcitability. In this review, we delve into the current understan...
Source: Trends in Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Yixun Su Alexei Verkhratsky Chenju Yi Source Type: research
SOX17: escape route from immune destruction in early CRC
Trends Mol Med. 2024 Apr 9:S1471-4914(24)00089-3. doi: 10.1016/j.molmed.2024.04.001. Online ahead of print.ABSTRACTIn a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5- (LGR5-) tumor cells, which suppress interferon gamma (IF...
Source: Trends in Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Kostas A Papavassiliou Christos Adamopoulos Athanasios G Papavassiliou Source Type: research
Pelizaeus-Merzbacher disease: on the cusp of myelin medicine
Trends Mol Med. 2024 Apr 5:S1471-4914(24)00060-1. doi: 10.1016/j.molmed.2024.03.005. Online ahead of print.ABSTRACTPelizaeus-Merzbacher disease (PMD) is caused by mutations in the proteolipid protein 1 (PLP1) gene encoding proteolipid protein (PLP). As a major component of myelin, mutated PLP causes progressive neurodegeneration and eventually death due to severe white matter deficits. Medical care has long been limited to symptomatic treatments, but first-in-class PMD therapies with novel mechanisms now stand poised to enter clinical trials. Here, we review PMD disease mechanisms and outline rationale for therapeutic inte...
Source: Trends in Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Matthew S Elitt Paul J Tesar Source Type: research
Molecular mechanisms in the pathogenesis of dengue infections
Trends Mol Med. 2024 Apr 5:S1471-4914(24)00061-3. doi: 10.1016/j.molmed.2024.03.006. Online ahead of print.ABSTRACTDengue is the most rapidly emerging climate-sensitive infection, and morbidity/mortality and disease incidence are rising markedly, leading to healthcare systems being overwhelmed. There are currently no specific treatments for dengue or prognostic markers to identify those who will progress to severe disease. Owing to an increase in the burden of illness and a change in epidemiology, many patients experience severe disease. Our limited understanding of the complex mechanisms of disease pathogenesis has signif...
Source: Trends in Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Gathsaurie Neelika Malavige Graham S Ogg Source Type: research
