MAM 2024: Malaria in a changing world
Trends Parasitol. 2024 Apr 11:S1471-4922(24)00074-6. doi: 10.1016/j.pt.2024.03.007. Online ahead of print.NO ABSTRACTPMID:38609740 | DOI:10.1016/j.pt.2024.03.007 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 12, 2024 Category: Parasitology Authors: Rhea J Longley Josephine Malinga Eva Hesping Edwin Sutanto Sophia M DonVito Michal Kucharski Damian A Oyong Julie M J Verhoef Esrah Du Elizabeth Villasis Kioko Mwikali Source Type: research
Regulation of host metabolic health by parasitic helminths
Trends Parasitol. 2024 Apr 11:S1471-4922(24)00073-4. doi: 10.1016/j.pt.2024.03.006. Online ahead of print.ABSTRACTObesity is a worldwide pandemic and major risk factor for the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). T2D requires lifelong medical support to limit complications and is defined by impaired glucose tolerance, insulin resistance (IR), and chronic low-level systemic inflammation initiating from adipose tissue. The current preventative strategies include a healthy diet, controlled physical activity, and medication targeting hyperglycemia, with underexplored underlying inflammation. Stud...
Source: Trends in Parasitology - April 12, 2024 Category: Parasitology Authors: Suchandan Sikder Doris Pierce Eti R Sarkar Connor McHugh Kate G R Quinlan Paul Giacomin Alex Loukas Source Type: research
A targetable receptor-binding site on PfCyRPA to aid in the fight against malaria
Trends Parasitol. 2024 Apr 10:S1471-4922(24)00083-7. doi: 10.1016/j.pt.2024.04.001. Online ahead of print.ABSTRACTRecently, Day et al. identified a receptor-binding site on the malaria parasite protein PfCyRPA that binds the host sugar Neu5Ac, and they found that disrupting this interaction impedes parasite growth. A map of the receptor-binding site identifies an attractive target for antimalarial vaccines and therapeutics.PMID:38604871 | DOI:10.1016/j.pt.2024.04.001 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 11, 2024 Category: Parasitology Authors: Thayne H Dickey Niraj H Tolia Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
A paradigm for Africa-centric vaccine development in Equatorial Guinea
Trends Parasitol. 2024 Apr 5:S1471-4922(24)00072-2. doi: 10.1016/j.pt.2024.03.005. Online ahead of print.ABSTRACTThe Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development of vaccines in Africa, for Africa. We review achievements and challenges of this pioneering, award-winning, public-private partnership which offers a model for future Africa-centric clinical research and development (R&D).PMID:38582683 | DOI:10.1016/j.pt.2024.03.005 (Source: Trends in Parasitology)
Source: Trends in Parasitology - April 6, 2024 Category: Parasitology Authors: Peter F Billingsley Thomas L Richie Salim Abdulla Mitoha Ondo'o Ayekaba Claudia A Daubenberger Gu íllermo A Garcia Stephen L Hoffman Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex
Trends Parasitol. 2024 Mar 25:S1471-4922(24)00054-0. doi: 10.1016/j.pt.2024.02.010. Online ahead of print.ABSTRACTMicrotubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heav...
Source: Trends in Parasitology - March 26, 2024 Category: Parasitology Authors: Albert Tell I Puig Dominique Soldati-Favre Source Type: research
