Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration
We examined the predictive properties of PGS25OHD, and two scores related to DBP concentration with respect to 1322 health-related phenotypes and 315 laboratory-measured phenotypes from electronic health records. In those with European ancestry: (a) the PGS25OHD and PGSDBP scores, and individual SNPs rs4588 and rs7041 were associated with both 25OHD concentration and 1,25 dihydroxyvitamin D concentrations; (b) higher PGS25OHD was associated with decreased concentrations of triglycerides and cholesterol, and reduced risks of vitamin D deficiency, disorders of lipid metabolism, and diabetes. In general, the findings for the ...
Source: Twin Research and Human Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Hailey A Kresge Freida Blostein Slavina Goleva Clara Albi ñana Joana A Revez Naomi R Wray Bjarni J Vilhj álmsson Zhihong Zhu John J McGrath Lea K Davis Source Type: research
In Memoriam: Dr. Auke Tellegen (July 16, 1930 - March 11, 2024)
Twin Res Hum Genet. 2024 Apr 19:1-3. doi: 10.1017/thg.2024.20. Online ahead of print.NO ABSTRACTPMID:38639037 | DOI:10.1017/thg.2024.20 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - April 19, 2024 Category: Genetics & Stem Cells Authors: Nancy L Segal Source Type: research
Genetic Causal Relationship Between Alanine Aminotransferase Levels and Risk of Gestational Diabetes Mellitus: Mendelian Randomization Analysis Based on Two Samples
Twin Res Hum Genet. 2024 Apr 18:1-5. doi: 10.1017/thg.2024.16. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is a frequent complication of pregnancy. The specific mechanisms underlying GDM have not yet been fully elucidated. Contemporary research indicates a potential association between liver enzyme irregularities and an increased risk of metabolic disorders, including diabetes. The alanine aminotransferase (ALT) level is recognized as a sensitive marker of liver injury. An increase in ALT levels is hypothesized to be linked to the pathogenesis of insulin resistance and diabetes. Nonetheless, the defin...
Source: Twin Research and Human Genetics - April 18, 2024 Category: Genetics & Stem Cells Authors: Lihua Yin Yifang Hu Xiaoxia Hu Xiaolei Huang Yingyuan Chen Yisheng Zhang Source Type: research
Genetic Causal Relationship Between Alanine Aminotransferase Levels and Risk of Gestational Diabetes Mellitus: Mendelian Randomization Analysis Based on Two Samples
Twin Res Hum Genet. 2024 Apr 18:1-5. doi: 10.1017/thg.2024.16. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is a frequent complication of pregnancy. The specific mechanisms underlying GDM have not yet been fully elucidated. Contemporary research indicates a potential association between liver enzyme irregularities and an increased risk of metabolic disorders, including diabetes. The alanine aminotransferase (ALT) level is recognized as a sensitive marker of liver injury. An increase in ALT levels is hypothesized to be linked to the pathogenesis of insulin resistance and diabetes. Nonetheless, the defin...
Source: Twin Research and Human Genetics - April 18, 2024 Category: Genetics & Stem Cells Authors: Lihua Yin Yifang Hu Xiaoxia Hu Xiaolei Huang Yingyuan Chen Yisheng Zhang Source Type: research
Brazilian Twin Studies: A Scoping Review
Twin Res Hum Genet. 2024 Apr 15:1-10. doi: 10.1017/thg.2024.17. Online ahead of print.ABSTRACTThe current study was motivated by an interest in deepening understanding of Brazilian twin research, which is underrepresented internationally, in an effort to rectify this situation. Our aim was threefold: (1) to carry out a comprehensive investigation of Brazilian research on twins according to the area of knowledge; (2) to evaluate the representation of research in the field of psychology in comparison with other areas; (3) to evaluate characteristics of the research that may have contributed to its exclusion from the comprehe...
Source: Twin Research and Human Genetics - April 15, 2024 Category: Genetics & Stem Cells Authors: Eloisa de Souza Fernandes Isabella Fran ça Ferreira Renata Pereira de Felipe Nancy Segal Emma Otta Source Type: research
Brazilian Twin Studies: A Scoping Review
Twin Res Hum Genet. 2024 Apr 15:1-10. doi: 10.1017/thg.2024.17. Online ahead of print.ABSTRACTThe current study was motivated by an interest in deepening understanding of Brazilian twin research, which is underrepresented internationally, in an effort to rectify this situation. Our aim was threefold: (1) to carry out a comprehensive investigation of Brazilian research on twins according to the area of knowledge; (2) to evaluate the representation of research in the field of psychology in comparison with other areas; (3) to evaluate characteristics of the research that may have contributed to its exclusion from the comprehe...
Source: Twin Research and Human Genetics - April 15, 2024 Category: Genetics & Stem Cells Authors: Eloisa de Souza Fernandes Isabella Fran ça Ferreira Renata Pereira de Felipe Nancy Segal Emma Otta Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome
This study raises questions regarding optimal maternal and fetal nutrition during surgery and if nutritional status could be optimized to further improve twin survival during fetoscopic surgery.PMID:38515292 | DOI:10.1017/thg.2024.10 (Source: Twin Research and Human Genetics)
Source: Twin Research and Human Genetics - March 22, 2024 Category: Genetics & Stem Cells Authors: Braxton Forde Samuel Martin Miki Watanabe-Chailland Foong-Yen Lim Source Type: research
