Psychosocial Impact of Penile Cancer
Penile cancer is a rare cancer, where patients not only need to deal with the anxiety around a cancer diagnosis, but also manage the consequences of treatment on their self-esteem, body image, and intimate relationships. Many find it embarrassing and difficult to talk to family and friends. Due to this, changes in urination and other physical effects of treatment, many will withdraw from social activities too. Patients need psychosocial support and more needs to be done to address this unmet need. Holistic and multidisciplinary approaches in clinic, with access to counseling, may help patients adjust to their new situation...
Source: Urologic Clinics of North America - April 16, 2024 Category: Urology & Nephrology Authors: Benjamin E. Ayres Source Type: research
MicroRNA for Prediction of Teratoma and Viable Germ Cell Tumor after Chemotherapy
MicroRNAs (miRNAs) are emerging as highly sensitive and specific markers for testicular germ cell tumors (GCTs) across the spectrum of disease. However, their utility in specific clinical scenarios requires further study. Here, we review the current evidence for miRNAs as tumor markers for the evaluation of treatment response in patients undergoing chemotherapy for the treatment of advanced testicular GCT. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 16, 2024 Category: Urology & Nephrology Authors: Fady J. Baky, Richard S. Matulewicz, Darren R. Feldman, Robert J. Hamilton, Aditya Bagrodia Source Type: research
Testicular Cancer Survivorship and Fertility Preservation
Testicular cancer disproportionally affects men of reproductive age making fertility an important aspect of testicular cancer survivorship. Men with testicular cancer have more semen parameter abnormalities and a higher incidence of infertility compared to the general population. All treatment options for testicular cancer negatively affect fertility with recovery rates varying by treatment. For these reasons, clinicians should offer sperm cryopreservation, ideally before orchiectomy to maximize the possibility of biologic paternity, if desired. Several innovations have positively impacted this space including direct-to-co...
Source: Urologic Clinics of North America - April 16, 2024 Category: Urology & Nephrology Authors: Aaron Tverye, Ajay Nangia, Richard J. Fantus Source Type: research
Immune-based Therapies for Penile Cancer
This article reviews penile squamous cell carcinoma (PSCC), a rare genitourinary cancer that has been increasing in prevalence. It discusses emerging therapies, focusing on immunotherapy, vaccine therapy, and cell-based treatments, especially in the context of human papillomavirus-related PSCC. Factors influencing these therapies are discussed. These include the immune microenvironment, programmed cell death ligand-1 expression, and tumor immune cell infiltration. This article also highlights immune checkpoint inhibitors and related clinical trials. This review supports the use of personalized medicine in treating PSCC. It...
Source: Urologic Clinics of North America - April 16, 2024 Category: Urology & Nephrology Authors: Majd Al Assaad, Houssein Safa, Chiara Mercinelli, Philippe E. Spiess, Andrea Necchi, Jad Chahoud Source Type: research
Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One
The landscape of squamous cell carcinoma of the penis (SCC-P) has undergone a significant transformation since the new World Health Organization classification of genitourinary cancers and recent European Association of Urology/American Association of Clinical Oncology guidelines. These changes emphasize the necessity to categorize SCC-P into 2 groups based on its association with human papillomavirus (HPV) infection. This shift has major implications, considering that prior knowledge was derived from a mix of both groups. Given the distinct prognosis, treatment options, and staging systems observed for HPV-associated tumo...
Source: Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Diego F. Sanchez, Pedro Oliveira Source Type: research
The Neurourology Journey: From Pads to Jack Lapides and Intermittent Catheterization to Multidisciplinary Management
This issue of Urologic Clinics of North America, edited by John T. Stoffel, represents the culmination of centuries of study of voiding dysfunction —its causes and treatments. Descriptions of urinary incontinence from spinal cord injury can be found as early as the second millennium bc in Egyptian manuscripts.1,2 Claudius Galen (129–201 ad) is credited as being the first to perform physiologic experiments on the lower-urinary tract, and he concluded that micturition is achieved by contraction of the abdominal muscles. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Authors: Kevin R. Loughlin Tags: Foreword Source Type: research
Updates in Neurourology
UROLOGIC CLINICS OF NORTH AMERICA (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Authors: John T. Stoffel Source Type: research
Copyright
ELSEVIER (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Source Type: research
Contributors
KEVIN R. LOUGHLIN, MD, MBA (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Source Type: research
Contents
Kevin R. Loughlin (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Source Type: research
Forthcoming Issues
Advances in Penile and Testicular Cancer (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Source Type: research
Update on the Management of Low-stage Seminoma
The contemporary paradigm of testicular cancer management is achieving high and durable cure rates while minimizing the burden of treatment given the potential long-term toxicities associated with radiation therapy and systemic therapies. The management of low-stage seminoma has seen significant changes in recent years. Nuances of surveillance strategies for stage I seminoma exist and continue to evolve. Emerging data show retroperitoneal lymph node dissection is a viable treatment option for selected patients with clinical stage IIA and IIB seminoma. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 9, 2024 Category: Urology & Nephrology Authors: Leilei Xia, Siamak Daneshmand Source Type: research
Regionalization of Testis Cancer Care —Is It Necessary?
Testicular germ cell tumors are rare genitourinary malignancies, but they represent the most common malignancies in men aged 15 to 30 years. Whereas the initial steps of management such as staging imaging studies, inguinal orchiectomy, and tumor marker can be performed elsewhere, the surgical and cytotoxic therapy needs to be done at reference centers. Regionalization of testis care has been shown to result in superior oncologic al outcome. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 9, 2024 Category: Urology & Nephrology Authors: Axel Heidenreich, Pia Paffenholz, David Pfister Source Type: research
A Primer for Primary Care Physicians Managing Neurogenic Bladder Patients
Primary care plays an important role in caring for neurogenic bladder patients. Clinicians should assess neurogenic bladder patients for common urologic symptoms/signs and refer to urology if refractory or safety issues are identified. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 12, 2024 Category: Urology & Nephrology Authors: Humphrey O. Atiemo, John Stoffel Source Type: research
A Framework for Addressing Health Disparities in Adult Neurogenic Lower Urinary Tract Dysfunction —Systematic Review and Neurogenic Bladder Research Group Recommendations
This report calls for a shift in focus from traditional urologic care to a broader, more inclusive perspective that accounts for the complex interplay of social, economic, and health care factors in managing NLUTD. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - March 12, 2024 Category: Urology & Nephrology Authors: Shanice Cox, Taiwo Dodo-Williams, Brandee Branche, Natalia Garc ía-Peñaloza, Mayra Lucas, Yahir Santiago-Lastra, Neurogenic Bladder Research Group Source Type: research
