Non-specific effects of the inactivated influenza vaccine. A test-negative study: The inactivated influenza vaccine and SARS-CoV-2 infections
CONCLUSIONS: While earlier observational studies suggested a protective non-specific effect of IIV and SARS-CoV-2 infections, this smaller, but well controlled test-negative design study does not suggest an effect, either positive or negative. Larger test-negative design studies, or alternative designs such as the self-controlled case series design are needed to confirm these findings and provide more definite answers on the topic.PMID:38658205 | DOI:10.1016/j.vaccine.2024.04.044 (Source: Vaccine)
Source: Vaccine - April 24, 2024 Category: Allergy & Immunology Authors: Anne Jasmijn Sellies Mirjam J Knol Hester E de Melker Patricia C J L Bruijning-Verhagen Annemarijn R de Boer Source Type: research
Who is getting COVID-19 boosters? A latent class analysis in a nationally representative sample of Mexican adults 60 years and over
CONCLUSIONS: Our analysis points to the need to reach out to men and women with elementary education or less who live in rural areas to strengthen booster campaigns in the future.PMID:38653678 | DOI:10.1016/j.vaccine.2024.04.004 (Source: Vaccine)
Source: Vaccine - April 23, 2024 Category: Allergy & Immunology Authors: Martha Carnalla Dalia Stern M Arantxa Colchero Karla Rangel-Moreno Ana Basto-Abreu Celia M Alpuche-Aranda Sergio Bautista-Arredondo Tonatiuh Barrientos-Guti érrez Source Type: research
A systematic review and meta-analysis on the effectiveness of bivalent mRNA booster vaccines against Omicron variants
CONCLUSIONS: The bivalent boosters demonstrated superior protection against severe outcomes than the original monovalent boosters across age groups, highlighting the critical need for improving vaccine coverage, especially among the vulnerable older subpopulation.PMID:38653679 | DOI:10.1016/j.vaccine.2024.04.049 (Source: Vaccine)
Source: Vaccine - April 23, 2024 Category: Allergy & Immunology Authors: Shangchen Song Zachary J Madewell Mingjin Liu Yu Miao Shaolin Xiang Yanan Huo Shoumi Sarkar Amily Chowdhury Ira M Longini Yang Yang Source Type: research
Analyzing the dynamics of meningococcal vaccinations initiatives by local government units in Poland (2017-2021) - Scope, challenges and recommendations
CONCLUSIONS: While LGUs activities positively contributed to increased meningococcal vaccination rates, the overall engagement of local governments remains limited. The findings underscore the importance of expanding local government involvement in meningococcal vaccination programs to address public health needs effectively. Improved collaboration and increased funding may enhance the reach and impact of these initiatives.PMID:38653680 | DOI:10.1016/j.vaccine.2024.04.046 (Source: Vaccine)
Source: Vaccine - April 23, 2024 Category: Allergy & Immunology Authors: Jakub Świtalski Wojciech Miazga Katarzyna Wnuk Tomasz Tatara Pawe ł Olszewski Mateusz Jankowski Anna Augustynowicz Source Type: research
BBIBP-CorV vaccine effectiveness against COVID-19 in patients aged 60 years and older during the Delta-dominant period in the Federation of Bosnia and Herzegovina, a test-negative case-control study
In this study, we estimated the vaccine effectiveness (VE) of complete primary series BBIBP-CorV vaccine against COVID-19 in patients aged 60 years and older, during the Delta-dominant period, using a test-negative case-control design. Surveillance sites were 11 primary health care centers (PHC) collecting patient data from October 1, 2021, to January 4, 2022, retrospectively according to a common protocol. In total, we included 1711 participants in the analysis: 933 cases and 778 controls. Of the 933 cases, 508 (54.4 %) had mild and 425 (45.6 %) had moderate to severe disease presentation. We observed no effectiveness aga...
Source: Vaccine - April 21, 2024 Category: Allergy & Immunology Authors: Sanjin Musa Lore Merdrignac Sinisa Skocibusic Rozalija Nedic Seila Cilovic-Lagarija Esther Kissling Source Type: research
BBIBP-CorV vaccine effectiveness against COVID-19 in patients aged 60 years and older during the Delta-dominant period in the Federation of Bosnia and Herzegovina, a test-negative case-control study
In this study, we estimated the vaccine effectiveness (VE) of complete primary series BBIBP-CorV vaccine against COVID-19 in patients aged 60 years and older, during the Delta-dominant period, using a test-negative case-control design. Surveillance sites were 11 primary health care centers (PHC) collecting patient data from October 1, 2021, to January 4, 2022, retrospectively according to a common protocol. In total, we included 1711 participants in the analysis: 933 cases and 778 controls. Of the 933 cases, 508 (54.4 %) had mild and 425 (45.6 %) had moderate to severe disease presentation. We observed no effectiveness aga...
Source: Vaccine - April 21, 2024 Category: Allergy & Immunology Authors: Sanjin Musa Lore Merdrignac Sinisa Skocibusic Rozalija Nedic Seila Cilovic-Lagarija Esther Kissling Source Type: research
Are the 7C psychological antecedents associated with COVID-19 vaccine behaviours beyond intentions? A cross-sectional study on at-least-one-dose and up-to-date vaccination status, and uptake speed among adults in France
CONCLUSION: This study demonstrates that the 7C not only explain vaccine intention, but also vaccine behaviours, and underpins the importance of developing vaccine promotion strategies considering the 7C antecedents.PMID:38643038 | DOI:10.1016/j.vaccine.2024.04.024 (Source: Vaccine)
Source: Vaccine - April 20, 2024 Category: Allergy & Immunology Authors: Ga ëlle Lièvre Jonathan Sicsic Simon Galmiche Tiffany Charmet Arnaud Fontanet Judith E Mueller Source Type: research
VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing response in mice
Vaccine. 2024 Apr 18:S0264-410X(24)00473-0. doi: 10.1016/j.vaccine.2024.04.048. Online ahead of print.ABSTRACTRespiratory syncytial virus (RSV) and human metapneumovirus (hMPV) vaccines have been long overdue. Structure-based vaccine design created a new momentum in the last decade, and the first RSV vaccines have finally been approved in older adults and pregnant individuals. These vaccines are based on recombinant stabilized pre-fusion F glycoproteins administered as soluble proteins. Multimeric antigenic display could markedly improve immunogenicity and should be evaluated in the next generations of vaccines. Here we te...
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Benjamin Trinit é Eberhard Durr Anna Pons-Gr ífols Gregory O'Donnell Carmen Aguilar-Gurrieri Silveria Rodriguez Victor Urrea Ferran Tarr és Joel Mane Raquel Ortiz Carla Rovirosa Jorge Carrillo Bonaventura Clotet Lan Zhang Juli à Blanco Source Type: research
Effect of the PCV 10 vaccination on community-acquired pneumonia hospitalisations after four years of its introduction into the Polish National Immunisation Programme: Follow-up study
CONCLUSIONS: Implementation of the PCV vaccination programme has effectively decreased the incidence of CAP hospitalisations, including children <2 years of age. The group that is most at risk of death are persons aged 60+. The results of our study can be useful in evaluating the vaccine efficacy and benefits, and they can be an essential part of public health policy. Effective prevention strategies for CAP should be implemented in different age groups.PMID:38641493 | DOI:10.1016/j.vaccine.2024.04.019 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Ma łgorzata Gajewska Katarzyna Lewtak Pawe ł Goryński Maria Piotrowicz Ewa Urban Iwona Paradowska-Stankiewicz Anna Rutyna Aneta Nitsch-Osuch Source Type: research
COVID-19 vaccine uptake among children and adolescents in Norway: A comprehensive registry-based cohort study of over 800,000 individuals
This study aimed to comprehensively examine individual and familial factors associated with vaccine uptake in children and adolescents in Norway. We utilized nationwide registry-data from various health registries and Statistics Norway, encompassing all children and adolescents living in Norway during the pandemic, until 31-Dec-2022. Vaccine uptake is defined as receiving at least one dose of COVID-19 vaccine. We employed a forward stepwise logistic regression model and a random forest machine-learning algorithm to explore the relationship between vaccine uptake and socio-cultural, demographic, and health-related factors. ...
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Saima Orangzeb Anteneh Desalegn Nhung T H Trinh Jing Zhao Hedvig Nordeng Angela Lupattelli Source Type: research
Predictors of willingness to receive updated 2023-2024 COVID-19 booster vaccines among a convenience sample in Minnesota
CONCLUSIONS: Our study emphasizes the importance of perceived vaccine safety as a predictor of intention to accept COVID-19 vaccines and highlights the continued need to effectively communicate with the public about the safety of vaccines.PMID:38641495 | DOI:10.1016/j.vaccine.2024.04.053 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: I J Ricke A B Spaulding N N Rajtar E M Benton I G Anderson L Lundberg A Mussiel R H N Nguyen Source Type: research
Safety of concomitant administration of 23-valent polysaccharide pneumococcal vaccine and influenza vaccine among the elderly
CONCLUSIONS: Concomitant administration of PPSV-23 and influenza vaccine in the elderly was not associated with a higher risk of most prespecified adverse events (AEs) compared to sequential vaccination. This study supports the safety of concomitant administration of PPSV-23 and influenza vaccine.PMID:38641496 | DOI:10.1016/j.vaccine.2024.03.078 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Heehyun Won Jeong Ah Kim Na-Young Jeong Nam-Kyong Choi Source Type: research
Leptospira-specific immunoglobulin Y (IgY) is protective in infected hamsters
In conclusion, passive immunotherapy with specific IgY can be considered an effective treatment for leptospirosis, and may replace antibiotics regarding its therapeutic effects.PMID:38641497 | DOI:10.1016/j.vaccine.2024.04.010 (Source: Vaccine)
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Tianbao Lv Xufeng Xie Luteng Diao Shuang Jiang Yue Ding Xin Yuan Lingling Gong Xi Chen Wenlong Zhang Yongguo Cao Source Type: research
Immunogenicity and protective efficacy of a multivalent herpesvirus vectored vaccine against H9N2 low pathogenic avian influenza in chicken
This study investigated H9- and ND-specific humoral and mucosal responses, H9-specific cell-mediated immunity, and protection conferred by the rHVT-H9-F vaccine in specific pathogen-free (SPF) chickens. Vaccination elicited systemic NDV F- and AIV H9-specific antibody response but also local antibodies in eye wash fluid and oropharyngeal swabs. The ex vivo H9-specific stimulation of splenic and pulmonary T cells in the vaccinated group demonstrated the ability of vaccination to induce systemic and local cellular responses. The clinical protection against a challenge using a LPAIV H9N2 strain of the G1 lineage isolated in M...
Source: Vaccine - April 19, 2024 Category: Allergy & Immunology Authors: Fiona Ingrao Eva Ngabirano Fabienne Rauw Gwena ëlle Dauphin B énédicte Lambrecht Source Type: research
Immunogenicity and safety of a 14-valent pneumococcal polysaccharide conjugate vaccine (PNEUBEVAX 14 ™) administered to 6-8 weeks old healthy Indian Infants: A single blind, randomized, active-controlled, Phase-III study
In this study, immunogenicity and safety of the BE's 14-valent PCV (PNEUBEVAX 14™; BE-PCV-14) containing two additional epidemiologically important serotypes (22F and 33F) was evaluated in infants in comparison to licensed vaccine, Prevenar-13 (PCV-13).METHODS: This is a pivotal phase-3 single blind randomized active-controlled study conducted at 12 sites across India in 6-8 weeks old healthy infants at 6-10-14 weeks dosing schedule to assess immunogenic non-inferiority and safety of a candidate BE-PCV-14. In total, 1290 infants were equally randomized to receive either BE-PCV-14 or PCV-13. Solicited local reactions and ...
Source: Vaccine - April 18, 2024 Category: Allergy & Immunology Authors: Ramesh V Matur Subhash Thuluva Subbareddy Gunneri Vijay Yerroju Rammohan Reddy Mogulla Kamal Thammireddy Piyush Paliwal Niranjana S Mahantshetty Mandyam Dhati Ravi S Prashanth Savita Verma Jai Prakash Narayan Source Type: research
