Comparative analysis of antiproliferative and vasodilator effects of drugs for pulmonary hypertension: Extensive in vitro study in rats and human
Vascul Pharmacol. 2024 Apr 8;155:107371. doi: 10.1016/j.vph.2024.107371. Online ahead of print.ABSTRACTAn effective pulmonary hypertension (PH) treatment should combine antiproliferative and vasodilator effects. We characterized a wide-range of drugs comparing their anti-proliferative vs vasodilator effects in human and rat pulmonary artery smooth muscle cells (PASMC). Key findings: 1) Approved PH drugs (PDE5 inhibitors, sGC stimulators and PGI2 agonists) are preferential vasodilators. 2) cGMP stimulators were more effective in cells derived from hypertensive rats. 3) Nifedipine acted equally as vasodilator and antiprolife...
Source: Vascular Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Daniel Morales-Cano Bianca Barreira Mar ía Callejo Miguel A Olivencia Antonio Ferruelo Javier Milara Jos é Ángel Lorente Laura Moreno Ángel Cogolludo Francisco Perez-Vizcaino Source Type: research
Comparative analysis of antiproliferative and vasodilator effects of drugs for pulmonary hypertension: Extensive in vitro study in rats and human
Vascul Pharmacol. 2024 Apr 8;155:107371. doi: 10.1016/j.vph.2024.107371. Online ahead of print.ABSTRACTAn effective pulmonary hypertension (PH) treatment should combine antiproliferative and vasodilator effects. We characterized a wide-range of drugs comparing their anti-proliferative vs vasodilator effects in human and rat pulmonary artery smooth muscle cells (PASMC). Key findings: 1) Approved PH drugs (PDE5 inhibitors, sGC stimulators and PGI2 agonists) are preferential vasodilators. 2) cGMP stimulators were more effective in cells derived from hypertensive rats. 3) Nifedipine acted equally as vasodilator and antiprolife...
Source: Vascular Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Daniel Morales-Cano Bianca Barreira Mar ía Callejo Miguel A Olivencia Antonio Ferruelo Javier Milara Jos é Ángel Lorente Laura Moreno Ángel Cogolludo Francisco Perez-Vizcaino Source Type: research
Comparative analysis of antiproliferative and vasodilator effects of drugs for pulmonary hypertension: Extensive in vitro study in rats and human
Vascul Pharmacol. 2024 Apr 8;155:107371. doi: 10.1016/j.vph.2024.107371. Online ahead of print.ABSTRACTAn effective pulmonary hypertension (PH) treatment should combine antiproliferative and vasodilator effects. We characterized a wide-range of drugs comparing their anti-proliferative vs vasodilator effects in human and rat pulmonary artery smooth muscle cells (PASMC). Key findings: 1) Approved PH drugs (PDE5 inhibitors, sGC stimulators and PGI2 agonists) are preferential vasodilators. 2) cGMP stimulators were more effective in cells derived from hypertensive rats. 3) Nifedipine acted equally as vasodilator and antiprolife...
Source: Vascular Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Daniel Morales-Cano Bianca Barreira Mar ía Callejo Miguel A Olivencia Antonio Ferruelo Javier Milara Jos é Ángel Lorente Laura Moreno Ángel Cogolludo Francisco Perez-Vizcaino Source Type: research
Comparative analysis of antiproliferative and vasodilator effects of drugs for pulmonary hypertension: Extensive in vitro study in rats and human
Vascul Pharmacol. 2024 Apr 8:107371. doi: 10.1016/j.vph.2024.107371. Online ahead of print.ABSTRACTAn effective pulmonary hypertension (PH) treatment should combine antiproliferative and vasodilator effects. We characterized a wide-range of drugs comparing their anti-proliferative vs vasodilator effects in human and rat pulmonary artery smooth muscle cells (PASMC). Key findings: 1) Approved PH drugs (PDE5 inhibitors, sGC stimulators and PGI2 agonists) are preferential vasodilators. 2) cGMP stimulators were more effective in cells derived from hypertensive rats. 3) Nifedipine acted equally as vasodilator and antiproliferati...
Source: Vascular Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Daniel Morales-Cano Bianca Barreira Mar ía Callejo Miguel A Olivencia Antonio Ferruelo Javier Milara Jos é Ángel Lorente Laura Moreno Ángel Cogolludo Francisco Perez-Vizcaino Source Type: research
Comparative analysis of antiproliferative and vasodilator effects of drugs for pulmonary hypertension: Extensive in vitro study in rats and human
Vascul Pharmacol. 2024 Apr 8:107371. doi: 10.1016/j.vph.2024.107371. Online ahead of print.ABSTRACTAn effective pulmonary hypertension (PH) treatment should combine antiproliferative and vasodilator effects. We characterized a wide-range of drugs comparing their anti-proliferative vs vasodilator effects in human and rat pulmonary artery smooth muscle cells (PASMC). Key findings: 1) Approved PH drugs (PDE5 inhibitors, sGC stimulators and PGI2 agonists) are preferential vasodilators. 2) cGMP stimulators were more effective in cells derived from hypertensive rats. 3) Nifedipine acted equally as vasodilator and antiproliferati...
Source: Vascular Pharmacology - April 10, 2024 Category: Drugs & Pharmacology Authors: Daniel Morales-Cano Bianca Barreira Mar ía Callejo Miguel A Olivencia Antonio Ferruelo Javier Milara Jos é Ángel Lorente Laura Moreno Ángel Cogolludo Francisco Perez-Vizcaino Source Type: research
Relevance of real-time analyzers to determine mitochondrial quality in endothelial cells and oxidative stress in preeclampsia
Vascul Pharmacol. 2024 Apr 6;155:107372. doi: 10.1016/j.vph.2024.107372. Online ahead of print.ABSTRACTOxidative stress and mitochondrial dysfunction are important elements for the pathophysiology of preeclampsia (PE), a multisystemic hypertensive syndrome of pregnancy, characterized by endothelial dysfunction and responsible for a large part of maternal and fetal morbidity and mortality worldwide. Researchers have dedicated their efforts to unraveling the intricate ways in which certain molecules influence both energy metabolism and oxidative stress. Exploring established methodologies from existing literature, shows that...
Source: Vascular Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: Priscila R Nunes Pedro F Oliveira Irene Rebelo Valeria C Sandrim Marco G Alves Source Type: research
Relevance of real-time analyzers to determine mitochondrial quality in endothelial cells and oxidative stress in preeclampsia
Vascul Pharmacol. 2024 Apr 5:107372. doi: 10.1016/j.vph.2024.107372. Online ahead of print.ABSTRACTOxidative stress and mitochondrial dysfunction are important elements for the pathophysiology of preeclampsia (PE), a multisystemic hypertensive syndrome of pregnancy, characterized by endothelial dysfunction and responsible for a large part of maternal and fetal morbidity and mortality worldwide. Researchers have dedicated their efforts to unraveling the intricate ways in which certain molecules influence both energy metabolism and oxidative stress. Exploring established methodologies from existing literature, shows that the...
Source: Vascular Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: Priscila R Nunes Pedro F Oliveira Irene Rebelo Valeria C Sandrim Marco G Alves Source Type: research
Relevance of real-time analyzers to determine mitochondrial quality in endothelial cells and oxidative stress in preeclampsia
Vascul Pharmacol. 2024 Apr 5:107372. doi: 10.1016/j.vph.2024.107372. Online ahead of print.ABSTRACTOxidative stress and mitochondrial dysfunction are important elements for the pathophysiology of preeclampsia (PE), a multisystemic hypertensive syndrome of pregnancy, characterized by endothelial dysfunction and responsible for a large part of maternal and fetal morbidity and mortality worldwide. Researchers have dedicated their efforts to unraveling the intricate ways in which certain molecules influence both energy metabolism and oxidative stress. Exploring established methodologies from existing literature, shows that the...
Source: Vascular Pharmacology - April 7, 2024 Category: Drugs & Pharmacology Authors: Priscila R Nunes Pedro F Oliveira Irene Rebelo Valeria C Sandrim Marco G Alves Source Type: research
Coronary artery disease and myocardial ischemic syndromes 2023 Proceedings of an International Expert Meeting Pisa, Italy 16-17 June 2023
Vascul Pharmacol. 2024 Apr 4;155:107370. doi: 10.1016/j.vph.2024.107370. Online ahead of print.NO ABSTRACTPMID:38579975 | DOI:10.1016/j.vph.2024.107370 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Raffaele De Caterina Peter Libby Source Type: research
Coronary artery disease and myocardial ischemic syndromes 2023 Proceedings of an International Expert Meeting Pisa, Italy 16-17 June 2023
Vascul Pharmacol. 2024 Apr 3:107370. doi: 10.1016/j.vph.2024.107370. Online ahead of print.NO ABSTRACTPMID:38579975 | DOI:10.1016/j.vph.2024.107370 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Raffaele De Caterina Peter Libby Source Type: research
A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo
Vascul Pharmacol. 2024 Mar 29;155:107369. doi: 10.1016/j.vph.2024.107369. Online ahead of print.ABSTRACTMouse models are invaluable to understanding fundamental mechanisms in vascular biology during development, in health and different disease states. Several constitutive or inducible models that selectively knockout or knock in genes in vascular endothelial cells exist; however, functional and phenotypic differences exist between microvascular and macrovascular endothelial cells in different organs. In order to study microvascular endothelial cell-specific biological processes, we developed a Tamoxifen-inducible von Wille...
Source: Vascular Pharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Dinesh Yadav Jeremy A Conner Yimin Wang Thomas L Saunders Eroboghene E Ubogu Source Type: research
A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo
Vascul Pharmacol. 2024 Mar 29;155:107369. doi: 10.1016/j.vph.2024.107369. Online ahead of print.ABSTRACTMouse models are invaluable to understanding fundamental mechanisms in vascular biology during development, in health and different disease states. Several constitutive or inducible models that selectively knockout or knock in genes in vascular endothelial cells exist; however, functional and phenotypic differences exist between microvascular and macrovascular endothelial cells in different organs. In order to study microvascular endothelial cell-specific biological processes, we developed a Tamoxifen-inducible von Wille...
Source: Vascular Pharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Dinesh Yadav Jeremy A Conner Yimin Wang Thomas L Saunders Eroboghene E Ubogu Source Type: research
A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo
Vascul Pharmacol. 2024 Mar 28:107369. doi: 10.1016/j.vph.2024.107369. Online ahead of print.ABSTRACTMouse models are invaluable to understanding fundamental mechanisms in vascular biology during development, in health and different disease states. Several constitutive or inducible models that selectively knockout or knock in genes in vascular endothelial cells exist; however, functional and phenotypic differences exist between microvascular and macrovascular endothelial cells in different organs. In order to study microvascular endothelial cell-specific biological processes, we developed a Tamoxifen-inducible von Willebran...
Source: Vascular Pharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Dinesh Yadav Jeremy A Conner Yimin Wang Thomas L Saunders Eroboghene E Ubogu Source Type: research
A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo
Vascul Pharmacol. 2024 Mar 28:107369. doi: 10.1016/j.vph.2024.107369. Online ahead of print.ABSTRACTMouse models are invaluable to understanding fundamental mechanisms in vascular biology during development, in health and different disease states. Several constitutive or inducible models that selectively knockout or knock in genes in vascular endothelial cells exist; however, functional and phenotypic differences exist between microvascular and macrovascular endothelial cells in different organs. In order to study microvascular endothelial cell-specific biological processes, we developed a Tamoxifen-inducible von Willebran...
Source: Vascular Pharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Dinesh Yadav Jeremy A Conner Yimin Wang Thomas L Saunders Eroboghene E Ubogu Source Type: research
A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo
Vascul Pharmacol. 2024 Mar 28:107369. doi: 10.1016/j.vph.2024.107369. Online ahead of print.ABSTRACTMouse models are invaluable to understanding fundamental mechanisms in vascular biology during development, in health and different disease states. Several constitutive or inducible models that selectively knockout or knock in genes in vascular endothelial cells exist; however, functional and phenotypic differences exist between microvascular and macrovascular endothelial cells in different organs. In order to study microvascular endothelial cell-specific biological processes, we developed a Tamoxifen-inducible von Willebran...
Source: Vascular Pharmacology - March 30, 2024 Category: Drugs & Pharmacology Authors: Dinesh Yadav Jeremy A Conner Yimin Wang Thomas L Saunders Eroboghene E Ubogu Source Type: research
