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The serological screening of deceased tissue donors within the English Blood Service for infectious agents – a review of current outcomes and a more effective strategy for the futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Overall, the NHSBT screening programme for infectious agents in deceased tissue donors is very effective with a relatively low overall loss of donors because of non-specific reactivity. However, unnecessary loss of tissue products is not acceptable, and although this programme compares favourably with the outcomes of other such programmes, the confirmatory results obtained demonstrate both the need and the potential for improving the outcomes. This is particularly important as one donor may donate more than one product, and can be achieved very easily with a change to the screening algorithm followed, using the ...
Source: Vox Sanguinis - November 19, 2009 Category: Hematology Authors: A. D. Kitchen, H. L. Gillan Source Type: journals

In vitro comparison of platelet storage in plasma and in four platelet additive solutions, and the effect of pathogen reduction: a proposal for an in vitro rating systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion PLT concentrates in plasma, SSP+ and Composol scored better using an arbitrary rating system as PLTs stored in T-Sol or InterSol; PR further impaired rating parameters. The applicability of these differences in rating for clinical effects needs a clinical study. (Source: Vox Sanguinis)
Source: Vox Sanguinis - November 18, 2009 Category: Hematology Authors: P. F. van der Meer, J.-L. Kerkhoffs, J. Curvers, J. Scharenberg, D. de Korte, A. Brand, J. de Wildt-Eggen Source Type: journals

Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Diagnostic efficacy of the evaluated HBsAg test kits differed substantially. Laboratories should therefore be aware of the analytical sensitivity for HBsAg and check for the relevant HBV variants circulating in the relevant population. (Source: Vox Sanguinis)
Source: Vox Sanguinis - November 4, 2009 Category: Hematology Authors: H. Scheiblauer, M. El-Nageh, S. Diaz, S. Nick, H. Zeichhardt, H.-P. Grunert, A. Prince Source Type: journals

Inventory ManagementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Vox Sanguinis)
Source: Vox Sanguinis - November 2, 2009 Category: Hematology Source Type: journals

Anticomplementary activity of IVIG concentrates – important assay parameters and impact of IgG polymersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion It was shown that suitable complement batches have to be identified in a screening procedure. Furthermore, it could be demonstrated that IgG polymers formed in the neutral pH range during heat treatment were potential ACA inducing compounds. Manufacturing the IVIG preparations under acidic conditions may help to avoid the formation of those ACA active polymers. Thus, intensive analysis of ACA during process development and validation is recommended. (Source: Vox Sanguinis)
Source: Vox Sanguinis - November 2, 2009 Category: Hematology Authors: A. Buchacher, P. Schluga, J. Müllner, M. Schreiner, C. Kannicht, J. Weinberger Source Type: journals

Applied tension may help retain donors who are ambivalent about needlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The experience of vasovagal symptoms may not deter people who are generally confident in their ability to tolerate blood donation. However, among people who are ambivalent about needles, symptoms may 'confirm' pre-existing doubts about their suitability for blood donation and lead to drop-out. Targeted interventions that give the uncertain volunteer a sense of confidence that they might be able to realize their goal and become a regular blood donor may be useful. (Source: Vox Sanguinis)
Source: Vox Sanguinis - November 2, 2009 Category: Hematology Authors: B. Ditto, C. R. France, C. Holly Source Type: journals

Should we increase the ratio of plasma/platelets to red blood cells in massive transfusion: what is the evidence?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although there is some evidence to support the increase use of plasma and platelets in massive transfusion, the true efficacy of such practice has not yet been proven by prospective randomized controlled trials. The available retrospective studies raise many important questions that need to be addressed in future clinical trials. (Source: Vox Sanguinis)
Source: Vox Sanguinis - November 2, 2009 Category: Hematology Authors: H. H. Phan, D. H. Wisner Source Type: journals

Coombs' crossmatch after negative antibody screening – a retrospective observational study comparing the tube test and the microcolumn technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion When an AHG XM becomes reactive after negative ABS result, this is caused with very few exceptions by clinically irrelevant reactivities. This especially accounts for reactive AHG XM using the MCT. (Source: Vox Sanguinis)
Source: Vox Sanguinis - November 2, 2009 Category: Hematology Authors: J. Lange, K. Selleng, N. M. Heddle, A. Traore, A. Greinacher Source Type: journals

Use of rFVIIa for critical bleeding in cardiac surgery: dose variation and patient outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings raise the important question of whether lower doses of rFVIIa may be as effective as higher doses in the treatment of severe bleeding in cardiac surgery patients. (Source: Vox Sanguinis)
Source: Vox Sanguinis - October 30, 2009 Category: Hematology Authors: C. Willis, R. Bird, D. Mullany, P. Cameron, L. Phillips Source Type: journals

Press ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Vox Sanguinis)
Source: Vox Sanguinis - October 29, 2009 Category: Hematology Source Type: journals

Safety of blood donation from individuals with treated hypertension or non-insulin dependent type 2 diabetes – a systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions No identified study indicated that raised baseline blood pressure level, treated hypertension or diabetes was predictive of increased adverse reactions in blood donors but the level of overall evidence was limited. This is the first attempt to systematically review a donor area as part of an approach to change longstanding practice recommendations, and may have implications for other recommendations for changes in donor acceptance criteria. (Source: Vox Sanguinis)
Source: Vox Sanguinis - October 29, 2009 Category: Hematology Authors: D. Stainsby, S. Brunskill, C. E. Chapman, C. Dorée, S. Stanworth Source Type: journals

Effect of iron supplementation on iron status during the first week after blood donationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Iron supplementation had a significant positive impact on the restoration of iron status one week after donation. (Source: Vox Sanguinis)
Source: Vox Sanguinis - October 28, 2009 Category: Hematology Authors: A. S. Røsvik, T. Hervig, T. Wentzel-Larsen, R. J. Ulvik Source Type: journals

Retrospective comparison of maternal vs. HPA-matched donor platelets for treatment of fetal alloimmune thrombocytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Donor and maternal platelet concentrates are effective sources for the treatment of FAIT. (Source: Vox Sanguinis)
Source: Vox Sanguinis - October 27, 2009 Category: Hematology Authors: G. Giers, F. Wenzel, J. Fischer, M. Stockschläder, R. Riethmacher, H. Lorenz, B. Tutschek Source Type: journals

Comprehensive polymorphism analysis of ABO using allele-specific separation by bead technology and subsequent sequencingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ABO system is the most important blood group system in transfusion and transplantation medicine. Over the last decade ABO genotyping was introduced to complement serological analysis but because of the enormous diversity at the ABO locus, DNA-based typing is highly sophisticated. In some genotype combinations and especially when dealing with hybrid genes, cis/trans linkage analysis is necessary. Therefore, we developed a simple and reliable approach to isolate ABO haplotypes. The described method physically separates diploid genomic DNA using probe-dependent allele hybridization followed by magnetic bead separation. Af...
Source: Vox Sanguinis - October 13, 2009 Category: Hematology Authors: M. Danzer, H. Polin, S. Stabentheiner, C. C. Hartmann, K. Lennartz, C. Gabriel Source Type: journals

Intravenous immunoglobulins induce potentially synergistic immunomodulations in autoimmune disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The increase in platelets in patients with immune thrombocytopenia (ITP) by intravenous administration of human immunoglobulin concentrates (IVIG) reflects a therapeutic immunomodulatory intervention targeted at the disturbed immune response in many inflammatory and autoimmune disorders. These immunoglobulin concentrates contain large numbers of antibodies as well as trace levels of various other immunologically active molecules. Clinical and laboratory studies have documented various mechanisms of action of IVIG. The complex network of immunological reactions resulting from the infusion of IVIG includes changes in several...
Source: Vox Sanguinis - October 11, 2009 Category: Hematology Authors: P. Imbach, A. H. Lazarus, T. Kühne Source Type: journals

Gender differences in presentation rates, deferrals and return behaviour among Norwegian blood donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Most of the gender differences in donation patterns could be ascribed to absence because of pregnancy and lactation. Practical problems and discomfort during donation were important reasons why women reported to have stopped donation. Current deferral criteria pose problems for the recruitment and retention especially of young women. (Source: Vox Sanguinis)
Source: Vox Sanguinis - October 6, 2009 Category: Hematology Authors: A. H. Misje, V. Bosnes, H. E. Heier Source Type: journals

Storage of buffy-coat-derived platelets in additive solutions: in vitro effects on platelets stored in reformulated PAS supplied by a 20% plasma carry-overEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that PLTs stored in PAS with addition of magnesium, potassium and glucose (PSM2 and PSM3) and 20% plasma carry-over maintained metabolic and cellular characteristics, equivalent to PLTs stored in 100% plasma during 9 days of storage. Our results also suggest that presence of potassium in addition to magnesium or alternatively the concentration of phosphate as well as the supply of additional glucose to normal plasma levels improve in vitro data of PLTs stored in PAS. (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 23, 2009 Category: Hematology Authors: P. Sandgren, V. Mayaudon, J.-M. Payrat, A. Sjödin, H. Gulliksson Source Type: journals

Evaluation of the analytical performances of a portable, 18-parameter hemometric system using capillary blood samples for blood donor enrolmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Data on Micros 60 demonstrated that capillary predonation counts may represent a feasible and effective approach to realize an accurate enrolment process of blood and Plt donors. (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 18, 2009 Category: Hematology Authors: L. Pierelli, F. Zennaro, D. Patti, M. Miceli, P. Iudicone, E. Mannella Source Type: journals

Factors influencing confidential unit exclusions in blood donorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Design of the CUE form and characteristics of the CUE process may considerably influence the CUE rates. (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 17, 2009 Category: Hematology Authors: A. Sümnig, U. Konerding, T. Kohlmann, A. Greinacher Source Type: journals

Evaluation of the confidential unit exclusion form: the Canadian Blood Services experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The data do not provide any indication of a safety benefit from CUE, but CUE use results in a small but constant loss of apparently safe donations. (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 13, 2009 Category: Hematology Authors: S. F. O'Brien, W. Fan, G. Xi, Q.-L. Yi, M. Goldman Source Type: journals

Allogeneic blood transfusion does not increase the risk of wound infection in total knee arthroplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study failed to find any association between the incidence of wound infection after knee arthroplasty and allogeneic transfusion. (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 13, 2009 Category: Hematology Authors: M. Basora, A. Pereira, A. Soriano, J. C. Martínez-Pastor, G. Sánchez-Etayo, M. Tió, F. Salazar Source Type: journals

Problems with irradiatorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Vox Sanguinis)
Source: Vox Sanguinis - September 13, 2009 Category: Hematology Authors: K. Tadokoro, H. W. Reesink, S. Panzer, A. Chabanel, G. Santailler, T. Guérin, D. Socquet, B. David, J. L. Labrune, C. K. Lin, W. C. Tsoi, M. Letowska, J. Antoniewicz Papis, J. Naniewicz, K. Dudziak, E. Lachert, M. Lozano, K. Schneider, E.L. Snyder, M.H. Source Type: journals

Assessing the safety and efficacy of a test-based, targeted donor screening strategy to minimize transfusion transmitted malariaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The study findings support the efficacy and safety of a targeted screening strategy combining a sensitive antibody screening test with a 4-month cellular component restriction period for donors with a declared malarial risk. The TTM risk in Australia remains low and did not measurably change after implementing the testing strategy. (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 8, 2009 Category: Hematology Authors: C. R. Seed, G. Kee, T. Wong, M. Law, S. Ismay Source Type: journals

A new blood group system, RHAG: three antigens resulting from amino acid substitutions in the Rh-associated glycoproteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The three red cell antigens encoded by RHAG form the RHAG blood group system: Duclos is RHAG1 (030001); Ola is RHAG2 (030002); and DSLK is provisionally RHAG3 (030003). (Source: Vox Sanguinis)
Source: Vox Sanguinis - September 7, 2009 Category: Hematology Authors: L. Tilley, C. Green, J. Poole, A. Gaskell, K. Ridgwell, N. M. Burton, M. Uchikawa, H. Tsuneyama, K. Ogasawara, Ç. A. Akkøk, G. Daniels Source Type: journals

Press ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Vox Sanguinis)
Source: Vox Sanguinis - September 3, 2009 Category: Hematology Source Type: journals

Characterization of plasma protein activity in riboflavin and UV light-treated fresh frozen plasma during 2 years of storage at −30°CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Riboflavin and UV light-treated plasma demonstrates reductions in several plasma coagulation factors following treatment. This reduction in activity levels is noted immediately after treatment and remains relatively constant during 2 years of storage at [minus]30°C. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 30, 2009 Category: Hematology Authors: D. J. Bihm, A. Ettinger, K. A. Buytaert-Hoefen, B. K. Hendrix, G. Maldonado-Codina, G. Rock, P. C. Giclas, R. P. Goodrich Source Type: journals

A comparative study of common techniques used to measure haemolysis in stored red cell concentratesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Harboe and Drabkin's methods are suitable for measuring total haemoglobin and supernatant haemoglobin in RCC. The analyser gave higher haematocrit values (11% on average) than did microcapillary centrifugation. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 29, 2009 Category: Hematology Authors: V. Han, K. Serrano, D. V. Devine Source Type: journals

INTERCEPT plasma: comparability with conventional fresh-frozen plasma based on coagulation function – an in vitro analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Treatment of plasma with the INTERCEPT Blood System preserves proteins necessary for haemostasis without inappropriate activation of coagulation, fibrinolytic or complement pathways. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 29, 2009 Category: Hematology Authors: J. Irsch, L. Pinkoski, L. Corash, L. Lin Source Type: journals

TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pulmonary damage in TRALI is related to formation of cholesterol crystals that appear to pierce endothelial membranes of venules. The endothelial defects lead to plasma extravasation into the alveoli causing TRALI. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 24, 2009 Category: Hematology Authors: H. M. Jensen, J. M. Galante, P. E. Kysar, V. V. Tolstikov, K. J. Reddy, P. V. Holland Source Type: journals

Prevalence and specificities of red blood cell alloantibodies in transfused Ugandans with different diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The prevalence of RBC alloimmunization in transfused Ugandans was 6·1% and was associated with the number of donor exposures. This immunization rate is similar to that observed in transfused Caucasians despite differences in RBC antigen distributions. Patients with malaria were less likely to develop RBC alloantibodies. Alloantibodies were mainly against E and S antigens. We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 23, 2009 Category: Hematology Authors: B. Natukunda, H. Schonewille, L. van de Watering, A. Brand Source Type: journals

Survey of current practice for prevention of transfusion-transmitted cytomegalovirus in the United States: leucoreduction vs. cytomegalovirus-seronegativeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion There is wide variability in transfusion practices to reduce the risk of TT-CMV. Lack of a consensus approach may reflect the conflicting data that exist in the literature as well as adherence to longstanding practice. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 19, 2009 Category: Hematology Authors: D. Smith, Q. Lu, S. Yuan, D. Goldfinger, L. P. Fernando, A. Ziman Source Type: journals

A new freezing and storage procedure improves safety and viability of haematopoietic stem cells and neutrophil engraftment: a single institution experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The new proposed method, based on a double bag and storage freezer without liquid or gas phase nitrogen into a cryogenic chamber, significantly reduces bag rupture and bio-hazard and improves stem cell viability and neutrophil engraftment remarkably. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 19, 2009 Category: Hematology Authors: L. Abbruzzese, M. Michieli, M. Rupolo, R. Tassan Toffola, A. Da Ponte, F. M. Rossi, D. Lorenzon, C. Simonelli, V. Gattei, L. De Marco, M. Mazzucato Source Type: journals

Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our data show that polymorphisms in the CD177 are associated with variations in the HNA-2 expression and may be the cause of atypical expressions. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 19, 2009 Category: Hematology Authors: E. Moritz, A. K. Chiba, E. Y. Kimura, D. Albuquerque, F. P. Guirão, M. Yamamoto, F. F. Costa, J. O. Bordin Source Type: journals

Triggers and appropriateness of red blood cell transfusions in the postpartum patient–a retrospective auditEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A significant proportion of postpartum RBC transfusions are possibly inappropriate, partly due to over-transfusion. If current guidelines would be more specific, in particular, with respect to the target Hb levels, the total amount of RBC transfusions may be considerably decreased. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 16, 2009 Category: Hematology Authors: C. So-Osman, J. Cicilia, A. Brand, M. Schipperus, B. Berning, S. Scherjon Source Type: journals

Frequency and severity of transfusion-related acute lung injury – German haemovigilance data (2006–2007)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective In an observational cohort study (2006[ndash]2007) the Paul-Ehrlich-Institut collected epidemiological data to investigate the frequency and causes of TRALI.Methods Diagnosis of TRALI was confirmed according to criteria of the European Haemovigilance Network. Subsequent testing of white blood cell antibodies (WBC-Ab) against HLA or human neutrophil alloantigens was performed.Results Of a total of 187 reported TRALI cases, 44 could be confirmed consisting of 35 cases of antibody-mediated TRALI and nine cases of non-immune-mediated TRALI. Eight of 44 affected patients (18%) had a fatal outcome, seven cases with WBC...
Source: Vox Sanguinis - August 5, 2009 Category: Hematology Authors: B. Keller-Stanislawski, A. Reil, S. Günay, M. B. Funk Source Type: journals

A retrospective case note review of deceased recipients of vCJD-implicated blood transfusionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A retrospective review of the medical case notes of the deceased recipients of vCJD-implicated blood components found no evidence that any further cases expressed clinical signs or symptoms suggestive of vCJD during life, but only four of the recipients survived for more than 5 years post-transfusion. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 5, 2009 Category: Hematology Authors: M. Gillies, G. Chohan, C. A. Llewelyn, J. MacKenzie, H. J. T. Ward, P. E. Hewitt, R. G. Will Source Type: journals

Microbiology, time course and clinical characteristics of infection in critically ill patients receiving packed red blood cell transfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Transfused ICU patients have a higher incidence of nosocomial infection and worse outcomes. Transfused patients had a shorter onset of infection. Acinetobacter infection appears to be particularly common among these patients. Further investigation is merited to better elucidate the mechanism for these findings and their therapeutic and clinical implications. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 3, 2009 Category: Hematology Authors: J.-S. Rachoin, R. Daher, C. Schorr, B. Milcarek, J. E. Parrillo, D. R. Gerber Source Type: journals

An international quality control programme for PRISM chemiluminescent immunoassays in blood service and blood product laboratoriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Analysis of test results of an external QC sample can be used as a statistical process control through ongoing measurement of imprecision. When laboratories test the same QC sample in the same assay and submit test results to a single database, the results can be compared and a measure of bias can be calculated. The resulting QC programme can offer detection of unexpected variation in the testing processes and the source of variation investigated. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 3, 2009 Category: Hematology Authors: S. Walker, W. Dimech, P. Kiely, K. Smeh, B. Francis, M. Karakaltsas, E. M. Dax Source Type: journals

Blood donor screening with cobas s 201/cobas TaqScreen MPX under routine conditions at German Red Cross institutesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The MPX test on s 201 system is a fully automated NAT system suitable for routine blood donor screening. The analytical sensitivity as well as the diagnostic sensitivity fulfilled all requirements of the Paul Ehrlich Institute for blood donor screening in mini-pools up to 96 donations per pool. A major benefit of the automated NAT system is the reduced personnel time and the extensive complete barcode-controlled process documentation. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 3, 2009 Category: Hematology Authors: M. Schmidt, L. Pichl, C. Jork, M. K. Hourfar, V. Schottstedt, F. F. Wagner, E. Seifried, T. H. Müller, J. Bux, J. Saldanha Source Type: journals

Bacterial screening of platelet concentrates: results of 2 years active surveillance of transfused positive cultured units released as negative to dateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Two of 158 transfusions of PCs released as 'negative to date', but with a confirmed positive BacT/ALERT result, were initially associated with transfusion reactions. However, the imputability of both reactions was low. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 3, 2009 Category: Hematology Authors: M. M. W. Koopman, E. van't Ende, R. Lieshout-Krikke, J. Marcelis, W. M. Smid, D. de Korte Source Type: journals

Red blood cell transfusion in the treatment and management of anaemia: the search for the elusive transfusion triggerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapeutic red blood cell (RBC) transfusion is widely utilized in the management of anaemia. Critically ill intensive care unit (ICU) patients in particular, as well as medical and haematology[ndash]oncology patients, are among the largest groups of users of RBC products. While anaemia is common in these patients, its treatment and management, including appropriate thresholds for RBC transfusion, remain controversial. We review here the function of RBCs in oxygen transport and physiology, with a view to their role in supporting and maintaining systemic tissue oxygenation. Adaptive and physiological compensatory mechanisms...
Source: Vox Sanguinis - August 3, 2009 Category: Hematology Authors: J. K. Wang, H. G. Klein Source Type: journals

Iron overload and toxicity: the hidden risk of multiple blood transfusionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Increased awareness of the risks of iron overload from chronic transfusion therapy should result in greater use of interventions such as iron chelation to reduce total body iron and the risk of long-term sequelae. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 2, 2009 Category: Hematology Authors: A. Shander, M. D. Cappellini, L. T. Goodnough Source Type: journals

Multicentre experience with a simple blood salvage technique in patients with ruptured ectopic pregnancy in sub-Sahelian West AfricaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The surgical treatment of ruptured ectopic pregnancy with intraperitoneal haemorrhage was rendered safe and efficient with this new salvaging equipment. (Source: Vox Sanguinis)
Source: Vox Sanguinis - August 2, 2009 Category: Hematology Authors: G. Priuli, R. Darate, R. X. Perrin, J. Lankoande, N. Drouet Source Type: journals

Mesenchymal stem cells for clinical applicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mesenchymal Stem Cells/Multipotent Marrow Stromal Cells (MSC) are multipotent adult stem cells present in all tissues, as part of the perivascular population. As multipotent cells, MSCs can differentiate into different tissues originating from mesoderm ranging from bone and cartilage, to cardiac muscle. Conflicting data show that MSCs could be pluripotent and able to differentiate into tissues and cells of non-mesodermic origin as neurons or epithelial cells. Moreover, MSCs exhibit non-HLA restricted immunosuppressive properties. This wide range of properties leads to increasing uses of MSC for immunomodulation or tissue r...
Source: Vox Sanguinis - August 2, 2009 Category: Hematology Authors: L. Sensebé, M. Krampera, H. Schrezenmeier, P. Bourin, R. Giordano Source Type: journals

Intravenous immunoglobulin G: trends in production methods, quality control and quality assuranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the developments that have led to modern IVIG preparations, the current methods used for plasma collection and fractionation, the safety measures implemented to minimize the risks of pathogen transmission and the major quality control tests that are available for product development and as part of mandatory batch release procedures. (Source: Vox Sanguinis)
Source: Vox Sanguinis - July 29, 2009 Category: Hematology Authors: M. Radosevich, T. Burnouf Source Type: journals

In vitro comparison of the complement-scavenging capacity of different intravenous immunoglobulin preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In vitro analysis allows comparison of the complement-inhibitory properties of IVIG preparations. The extent of complement scavenging varies between the products. (Source: Vox Sanguinis)
Source: Vox Sanguinis - July 27, 2009 Category: Hematology Authors: M. Spycher, K. Matozan, K. Minnig, R. Zehnder, S. Miescher, L. Hoefferer, R. Rieben Source Type: journals

A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Implementation of a uniform transfusion protocol for elective lower joint arthroplasty patients is feasible, but does not always lead to a RBC reduction. Length of hospital stay was not affected. (Source: Vox Sanguinis)
Source: Vox Sanguinis - July 22, 2009 Category: Hematology Authors: C. So-Osman, R. Nelissen, R. Te Slaa, L. Coene, R. Brand, A. Brand Source Type: journals

The use of cord blood for transfusion purposes: current statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the use of umbilical cord blood (UCB) for transfusion purposes has been proposed decades ago, the employ is still limited. In this article we review studies evaluating UCB collection efficiency and sterility, examine processing and storage of UCB-derived red blood cells (RBC) and discuss clinical studies in which UCB was used for transfusion purposes. Efforts to provide preterm newborns with autologous RBC derived from UCB have not been very successful. UCB collected after full-term deliveries can however easily be processed into RBC products and could be used autologous in case surgery of the neonate is indicated...
Source: Vox Sanguinis - June 29, 2009 Category: Hematology Authors: C. M. Khodabux, A. Brand Source Type: journals