Wiley Interdisciplinary Reviews: Nanomedicine and NanobiotechnologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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22 records returned

Carbon nanotubes towards medicinal biochipsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This overview focuses on the recent advances in carbon nanotube (CNT)-based biochips and tries to clarify their potential for modern molecular medicine Copyright © 2009 John Wiley & Sons, Inc. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 18, 2009 Category: Nanotechnology Authors: Alexander O. Tarakanov, Larisa B. Goncharova, Yury A. Tarakanov Source Type: journals

Nanogenomics in medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review presents the status of technological developments of nanogenomics and its applications to medicine. Even if particular emphasis is placed on what has been accomplished in our laboratory in the last few years in the area of genes microarrays, significant reference to the recent activity of numerous other groups can be found in Refs , Copyright © 2009 John Wiley & Sons, Inc. (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 3, 2009 Category: Nanotechnology Authors: Claudio Nicolini Source Type: journals

Nanotechnology in the design of soft tissue scaffolds: innovations in structure and functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the major nanofiber fabrication technologies as well as delves into recent significant contributions to the conception of a meaningful and practical electrospun scaffold. Copyright © 2009 John Wiley & Sons, Inc.For further resources related to this article, please visit the . (Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology)
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 30, 2009 Category: Nanotechnology Authors: Chantal E. Ayres, B. Shekhar Jha, Scott A. Sell, Gary L. Bowlin, David G. Simpson Source Type: journals

Probing dynamic fluorescence properties of single and clustered quantum dots toward quantitative biomedical imaging of cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present results on the dynamic fluorescence properties of bioconjugated nanocrystals or quantum dots (QDs) in different chemical and physical environments. A variety of QD samples was prepared and compared: isolated individual QDs, QD aggregates, and QDs conjugated to other nanoscale materials, such as single-wall carbon nanotubes (SWCNTs) and human erythrocyte plasma membrane proteins. We discuss plausible scenarios to explain the results obtained for the fluorescence characteristics of QDs in these samples, especially for the excitation time-dependent fluorescence emission from clustered QDs. We also qualitatively dem...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 29, 2009 Category: Nanotechnology Authors: Hyeong-Gon Kang, Fuyuki Tokumasu, Matthew Clarke, Zhenping Zhou, Jianyong Tang, Tinh Nguyen, Jeeseong Hwang Source Type: journals

Non-viral gene therapy for myocardial engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted myocardium. Once the blood supply to the area in question is interrupted, the inflammatory cascade, among other mechanisms, results in the damaged tissue becoming a scar. The goals of cardiac gene therapy are essentially to minimize damage, to promote regeneration, or some combination thereof. While the vector is, in theory, less important than the gene being delivered, the choice of vector can have a...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 28, 2009 Category: Nanotechnology Authors: Carolyn A. Holladay, Timothy O'Brien, Abhay Pandit Source Type: journals

Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A survey of research activity on nanoparticles (NPs) based on polymeric devices that could cross the blood-brain barrier (BBB) is given along with the presentation of our own data on the development of NPs of n-butyl-2-cyanoacrylate (BCA) for brain delivery to aid the early diagnosis of Alzeimer's disease (AD), a neurodegenerative disorder of the elderly people, the most prevalent form of dementia. Typical data are presented on in vivo detection of amyloid peptides (A[beta]) (amyloid plaques) that are used as targets for developing the biological markers for the diagnosis of AD. In order to develop efficient in vivo probes...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 5, 2009 Category: Nanotechnology Authors: Padmakar V. Kulkarni, Celeste A. Roney, Peter P. Antich, Frederick J. Bonte, Anjanapura V. Raghu, Tejraj M. Aminabhavi Source Type: journals

Transplacental transport of nanomaterialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The unique properties of nanoparticles (NP) are key to the excitement over their potential application to benefit many aspects of our lives, but are also the cause of concern over inadequate toxicological assessment of their possible impact on human health. Nanotechnology is a rapidly expanding area of industrial activity in which NP are being developed for a wide range of purposes. With some of these products already in use, and many more soon to follow, it is critically important that the potential risks from this new technology are properly assessed. There is a pressing need to understand how engineered NP can interact ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 4, 2009 Category: Nanotechnology Authors: Margaret Saunders Source Type: journals

Atomic force microscopy and indentation force measurement of boneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review is summarizing the results obtained from atomic force microscopy (AFM) and nanoindentation experiments to date. The combination of both techniques is especially powerful. It allows to carefully choose indentation locations as well as the post-hoc analysis of the created indents, and hence the possibility to assess the properties of microstructural elements of bonessue. In addition, AFM has improved our understanding of bone ultrastructure and force spectroscopy experiments have led to the discovery of a molecular self-healing effect of bone that may be based on a small fraction of unstructured proteins. Nanoind...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 4, 2009 Category: Nanotechnology Authors: Philipp J. Thurner Source Type: journals

Complex mathematical models of biology at the nanoscaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mathematical modeling of nanobiosystems is an exciting and rapidly growing new field of research that offers the potential to guide and improve technological developments in both nanomedicine and nanobiomaterial science. Unlike the more traditional fields of science and engineering, however, models of nanobiosystems are notoriously complex. In this paper, we highlight some of the primary sources of complexity in nanobiosystems. In particular, we focus on complexity that arises from the inherent nonlinearity of natural systems, noise generated by low copy numbers of relevant biological constituents, heterogeneity that stems...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - October 4, 2009 Category: Nanotechnology Authors: Sharon Bewick, Ruoting Yang, Mingjun Zhang Source Type: journals

Nanoparticles in sentinel lymph node mappingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The lymph nodes and lymphatic vessels are more difficult to access than most vascular structures. Interstitial injection of imaging agents is often necessary to opacify the lymphatics. Traditionally, radionuclide methods of sentinel node imaging have dominated this field, however, limitations in resolution and exposure to radiation have encouraged the development of newer imaging methods. Among these are magnetic resonance lymphography in which a Gadolinium labeled nanoparticle is injected and imaged providing superior anatomic resolution and assessment of lymphatic dynamics. Optical imaging employing various nanoparticles...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - September 14, 2009 Category: Nanotechnology Authors: Gregory Ravizzini, Baris Turkbey, Tristan Barrett, Hisataka Kobayashi, Peter L. Choyke Source Type: journals

Molecular beacons and related probes for intracellular RNA imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accurately imaging endogenous or non-engineered RNA in live cells is not an easy task. Ideally, a probe and imaging strategy will have the following properties: (1) functional probes will be delivered to the desired cellular compartment, (2) they will achieve the correct level of affinity to bind target RNA efficiently but not inhibit their function, (3) be sensitive enough to allow for the accurate detection of the cellular RNA population, and (4) allow for the tracking of RNA through biogenesis, transport, translation, and degradation pathways. In this review, the capabilities of current nucleic acid-based probes and str...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - September 2, 2009 Category: Nanotechnology Authors: Philip J. Santangelo Source Type: journals

Assessing nanotoxicity in cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nanomaterials are commonly defined as particles or fibers of less than 1 µm in diameter. For these reasons, they may be respirable in humans and have the potential, based upon their geometry, composition, size, and transport or durability in the body, to cause adverse effects on human health, especially if they are inhaled at high concentrations. Rodent inhalation models to predict the toxicity and pathogenicity of nanomaterials are prohibitive in terms of time and expense. For these reasons, a panel of in vitro assays is described below. These include cell culture assays for cytotoxicity (altered metabolism, decreased gr...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - September 2, 2009 Category: Nanotechnology Authors: Jedd M. Hillegass, Arti Shukla, Sherrill A. Lathrop, Maximilian B. MacPherson, Naomi K. Fukagawa, Brooke T. Mossman Source Type: journals

Nanotechnology in joint replacementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper reviews the most relevant achievements and new developments in the field of nanomaterials and their possible impact on the fabrication of a new generation of reliable and longer lasting implants for joint replacement. Special emphasis is given to the role of nanocomposites with different microstructural designs: micro-nano composites, nano-nano composites, macro-micro-nano composites as well as bioinspired hierarchical composite materials. These nanostructured materials have opened up an exciting avenue in the design of non-metallic biocompatible, crack growth resistant, tough, and mechanically resistant implant...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 3, 2009 Category: Nanotechnology Authors: Ramón Torrecillas, José S. Moya, Luis A. Díaz, José F. Bartolomé, Adolfo Fernández, Sonia Lopez-Esteban Source Type: journals

Monodisperse magnetic nanoparticles for biodetection, imaging, and drug delivery: a versatile and evolving technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Advances in nanotechnology have pushed forward the synthesis of a variety of functional nanoparticles (NPs) such as semiconductor quantum dots (QDs), magnetic and metallic NPs. The unique electronic, magnetic, and optical properties exhibited by these nanometer-sized materials have enabled a broad spectrum of biomedical applications. In particular, iron-oxide-based magnetic NPs have proved to be highly versatile deep-tissue imaging agents, having been incorporated into clinical applications due to their biocompatibility. This Interdisciplinary Review will focus on the recent advances in strategies for the synthesis and sur...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 2, 2009 Category: Nanotechnology Authors: Shivang R. Dave, Xiaohu Gao Source Type: journals

Nanoporous membranes for medical and biological applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Synthetic nanoporous materials have numerous potential biological and medical applications that involve sorting, sensing, isolating, and releasing biological molecules. Nanoporous systems engineered to mimic natural filtration systems are actively being developed for use in smart implantable drug delivery systems, bioartificial organs, and other novel nano-enabled medical devices. Recent advances in nanoscience have made it possible to precisely control the morphology as well as physical and chemical properties of the pores in nanoporous materials that make them increasingly attractive for regulating and sensing transport ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 27, 2009 Category: Nanotechnology Authors: Shashishekar P. Adiga, Chunmin Jin, Larry A. Curtiss, Nancy A. Monteiro-Riviere, Roger J. Narayan Source Type: journals

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human diseases associated with exposure to asbestos fibers include pleural fibrosis and plaques, pulmonary fibrosis (asbestosis), lung cancer, and diffuse malignant mesothelioma. The critical determinants of fiber bioactivity and toxicity include not only fiber dimensions, but also shape, surface reactivity, crystallinity, chemical composition, and presence of transition metals. Depending on their size and dimensions, inhaled fibers can penetrate the respiratory tract to the distal airways and into the alveolar spaces. Fibers can be cleared by several mechanisms, including the mucociliary escalator, engulfment, and removal...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 26, 2009 Category: Nanotechnology Authors: Vanesa C. Sanchez, Jodie R. Pietruska, Nathan R. Miselis, Robert H. Hurt, Agnes B. Kane Source Type: journals

NanobiosystemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
'Nanobiosystems' is a relatively new term describing objects in the size range below 150 nm and having structures or functions that link to biological functions. Key features are that these nanosized objects typically self-assemble, are not capable of self-replication, and have functions that take advantage of its size. Nanobiosystems can be made entirely of biological or organic molecules that are organized into nanoparticles (e.g., liposomes, dendrimers) or be totally inorganic (with the exception of surface coatings used for biocompatibility) nanoparticles (e.g., gold, iron oxide, quantum dot nanocrystals). More complex...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 26, 2009 Category: Nanotechnology Authors: Mary-Margaret Seale-Goldsmith, James F. Leary Source Type: journals

ATP-loaded liposomes for treatment of myocardial ischemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe methods for optimized encapsulation of ATP in liposomes, enhancement of their effectiveness by increasing circulation time, and targeting of injured myocardial cells with surface attached antimyosin. In isolated ischemic rat hearts, ATP-loaded liposomes and ATP-loaded immunoliposomes effectively protected myocardium from ischemia/reperfusion damage as measured by systolic and diastolic functional improvements. In vivo, in rabbits with induced localized myocardial ischemia, liposomal encapsulation of ATP significantly diminished the proportion of ventricular muscle at risk that was irreversibly damaged during re...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 13, 2009 Category: Nanotechnology Authors: William C. Hartner, Daya D. Verma, Tatyana S. Levchenko, Eugene A. Bernstein, Vladimir P. Torchilin Source Type: journals

Methotrexate delivery via folate targeted dendrimer-based nanotherapeutic platformEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper provides a synopsis of the advancements made in advancing a dendrimer-based nanomedicine towards human clinical trials by the Michigan Nanotechnology Institute for Medicine and Biological Sciences. A brief description of the synthesis and characterization of a targeted multifunctional therapeutic will demonstrate the simple yet delicate task of producing novel chemotherapeutic agents. The results obtained from in vitro and in vivo studies not only authenticate the potential of using nanoparticles to target therapeutics but also provide valuable insight towards the future directions of this technology. A fundamen...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - June 24, 2009 Category: Nanotechnology Authors: István J. Majoros, Christopher R. Williams, Andrew Becker, James R. Baker Jr. Source Type: journals

Fluorine-containing nanoemulsions for MRI cell trackingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this article we review the chemistry and nanoemulsion formulation of perfluorocarbons used for in vivo 19F MRI cell tracking. In this application, cells of interest are labeled in culture using a perfluorocarbon nanoemulsion. Labeled cells are introduced into a subject and tracked using 19F MRI or NMR spectroscopy. In the same imaging session, a high-resolution, conventional (1H) image can be used to place the 19F-labeled cells into anatomical context. Perfluorocarbon-based 19F cell tracking is a useful technology because of the high specificity for labeled cells, ability to quantify cell accumulations, and biocompatibi...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 25, 2009 Category: Nanotechnology Authors: Jelena M. Janjic, Eric T. Ahrens Source Type: journals

Magnetic quantum dots for multimodal imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multimodal contrast agents based on highly luminescent quantum dots (QDs) combined with magnetic nanoparticles (MNPs) or ions form an exciting class of new materials for bioimaging. With two functionalities integrated in a single nanoparticle, a sensitive contrast agent for two very powerful and highly complementary imaging techniques [fluorescence imaging and magnetic resonance imaging (MRI)] is obtained. In this review, the state of the art in this rapidly developing field is given. This is done by describing the developments for four different approaches to integrate the fluorescence and magnetic properties in a single ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 12, 2009 Category: Nanotechnology Authors: Rolf Koole, Willem J. M. Mulder, Matti M. van Schooneveld, Gustav J. Strijkers, Andries Meijerink, Klaas Nicolay Source Type: journals

Polyalkylcyanoacrylate nanoparticles for delivery of drugs across the blood-brain barrierEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The major problem in drug delivery to the brain is the presence of the blood-brain barrier (BBB) which limits drug penetration even if in certain pathological situations the BBB is partly disrupted. Among noninvasive techniques to overcome this barrier, the use of nanoparticles has been proposed. This review focuses on poly(alkylcyanoacrylates) (PACA)-based nanoparticles which have been developed for brain targeting. Both types of 'stealth' PACA nanoparticles with modified surface, those coated with surfactant and those with chains of polyethylene glycol (PEG) linked to the hydrophobic core of PACA are presented. The synth...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 12, 2009 Category: Nanotechnology Authors: Karine Andrieux, Patrick Couvreur Source Type: journals