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Genome-wide association studies--a summary for the clinical gastroenterologist.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genome-wide association studies (GWAS) have been applied to various gastrointestinal and liver diseases in recent years. A large number of susceptibility genes and key biological pathways in disease development have been identified. So far, studies in inflammatory bowel diseases, and in particular Crohn's disease, have been especially successful in defining new susceptibility loci using the GWAS design. The identification of associations related to autophagy as well as several genes involved in immunological response will be important to future research on Crohn's disease. In this review, key methodological aspects of ...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Melum E, Franke A, Karlsen TH Tags: World J Gastroenterol Source Type: journals

Peutz-Jeghers syndrome: diagnostic and therapeutic approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280,000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgen...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Kopacova M, Tacheci I, Rejchrt S, Bures J Tags: World J Gastroenterol Source Type: journals

Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA(-) strains, can exert a gastroprotective effect. PMID: 19916170 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Stec-Michalska K, Malicki S, Michalski B, Peczek L, Wisniewska-Jarosinska M, Nawrot B Tags: World J Gastroenterol Source Type: journals

Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine. The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. PMID: 19916171 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Ersoy B, Ozbilgin K, Kasirga E, Inan S, Coskun S, Tuglu I Tags: World J Gastroenterol Source Type: journals

Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results indicate that WFS1 may be involved in some aspects of pancreatic development and further research on WFS1 may provide new evidences to prove the interactions between mesenchyma and epithelia at the same time. PMID: 19916172 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Xu R, Xia B, Geng J, Shi J, Shi H, Yuan L, De W Tags: World J Gastroenterol Source Type: journals

Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrin beta1 and CD44V6, by which cell adhesion and metastasis to the ECM are promoted. PMID: 19916173 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Ou XL, Chen HJ, Sun WH, Hang C, Yang L, Guan YY, Yan F, Chen BA Tags: World J Gastroenterol Source Type: journals

Stable knockdown of heparanase expression in gastric cancer cells in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Stable knockdown of heparanase can efficiently decrease the invasiveness, metastasis and angiogenesis of human gastric cancer cells. In contrast, stable knockdown of heparanase does not affect the cell proliferation. PMID: 19916174 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Zheng LD, Jiang GS, Pu JR, Mei H, Dong JH, Hou XH, Tong QS Tags: World J Gastroenterol Source Type: journals

G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasing neutrophil count, prolonging treatment and leading to sustained virological response (SVR) rates comparable to non-neutropenic patients. It prevents the occurrence of de novo autoimmune hepatitis. PMID: 19916175 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Lodato F, Azzaroli F, Tamè MR, Di Girolamo M, Buonfiglioli F, Mazzella N, Cecinato P, Roda E, Mazzella G Tags: World J Gastroenterol Source Type: journals

Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients. PMID: 19916176 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Douzinas EE, Andrianakis I, Livaditi O, Bakos D, Flevari K, Goutas N, Vlachodimitropoulos D, Tasoulis MK, Betrosian AP Tags: World J Gastroenterol Source Type: journals

Manometric findings in patients with isolated distal gastroesophageal reflux.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Patients with erosive and non-erosive disease present with similar manometric abnormalities. The only striking difference is the observation of very low EBCA exclusively in patients with erosive disease. PMID: 19916177 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Ozin Y, Dagli U, Kuran S, Sahin B Tags: World J Gastroenterol Source Type: journals

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Working or exercising after meals and H pylori infection increase the risk of GCA, but higher intakes of rice, fresh vegetables and fruits reduce the risk. PMID: 19916179 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chen MJ, Wu DC, Lin JM, Wu MT, Sung FC Tags: World J Gastroenterol Source Type: journals

Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC. PMID: 19916180 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chan KM, Yu MC, Wu TJ, Lee CF, Chen TC, Lee WC, Chen MF Tags: World J Gastroenterol Source Type: journals

Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm (IPMN) in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 mo. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were con...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Sakamoto H, Kitano M, Komaki T, Imai H, Kamata K, Kimura M, Takeyama Y, Kudo M Tags: World J Gastroenterol Source Type: journals

Spontaneous liver rupture in a patient with peliosis hepatis: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver failure. Here, we present a young male patient with aplastic anemia, who had received long-term treatment with oxymetholone. The patient suffered from sudden onset of intra-abdominal hemorrhage with profuse hemoperitoneum. The patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative months. We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility ...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Choi SK, Jin JS, Cho SG, Choi SJ, Kim CS, Choe YM, Lee KY Tags: World J Gastroenterol Source Type: journals

Hepatitis B markers and vaccination-induced protection rate among Albanian pregnant women in Greece.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis B has long been a serious public health problem both in Greece and in Albania. In the February 2009 issue of World Journal of Gastroenterology, Resuli et al presented the interesting epidemiological data concerning hepatitis B virus infection in Albania. The results of this study were discussed and several data from our similar research were provided. PMID: 19916183 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Elefsiniotis IS, Vezali E, Brokalaki H, Tsoumakas K Tags: World J Gastroenterol Source Type: journals

Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin, a polymer of N-acetylglucosamine. Chitin is the structural component of fungi, crustaceans, insects and parasitic nematodes, but is completely absent in mammals. Exposure to antigens containing chitin- or chitin-like structures sometimes induces strong T helper type-I responses in mammals, which may be associated with the induction of mammalian chitinases. Chitinase 3-like-1 (CHI3L1), a member of the mammalian chitinase family, is induced specifically during the course of inflammation in such diso...
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Eurich K, Segawa M, Toei-Shimizu S, Mizoguchi E Tags: World J Gastroenterol Source Type: journals

Experimental evidence of obesity as a risk factor for severe acute pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of acute pancreatitis, an inflammation of the pancreas, is increasing worldwide. Pancreatic injury is mild in 80%-90% of patients who recover without complications. The remaining patients may develop a severe disease with local complications such as acinar cell necrosis, abscess and remote organ injury including lung injury. The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications. For that purpose, multiple clinical scale scores have be...
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Frossard JL, Lescuyer P, Pastor CM Tags: World J Gastroenterol Source Type: journals

Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE. PMID: 19908333 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Parra-Blanco A, Jiménez A, Rembacken B, González N, Nicolás-Pérez D, Gimeno-García AZ, Carrillo-Palau M, Matsuda T, Quintero E Tags: World J Gastroenterol Source Type: journals

Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. PMID: 19908334 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Jamal MM, Yoon EJ, Vega KJ, Hashemzadeh M, Chang KJ Tags: World J Gastroenterol Source Type: journals

Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Tumor resection and comorbidity emerged as significant prognostic variables in extrahepatic cholangiocarcinoma. Comorbidity evaluation instruments should be applied in the clinical management of such patients. PMID: 19908335 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Fernández-Ruiz M, Guerra-Vales JM, Colina-Ruizdelgado F Tags: World J Gastroenterol Source Type: journals

Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The significantly thinner mucosa of IBD patients showed a predominance of some aerobes specific for particular diseases, their numbers decreased in relation to higher clinical and endoscopic activity of the disease. PMID: 19908336 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Fyderek K, Strus M, Kowalska-Duplaga K, Gosiewski T, Wedrychowicz A, Jedynak-Wasowicz U, Sładek M, Pieczarkowski S, Adamski P, Kochan P, Heczko PB Tags: World J Gastroenterol Source Type: journals

Fructose-sorbitol ingestion provokes gastrointestinal symptoms in patients with eating disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: F-S, but not glucose, provokes GI symptoms in ED patients, predominantly those with low BMI. These findings are important in the dietary management of ED patients. PMID: 19908337 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Friesen N, Hansen RD, Abraham SF, Kellow JE Tags: World J Gastroenterol Source Type: journals

Small bowel MRI enteroclysis or follow through: Which is optimal?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: All patients could be successfully imaged in the supine position. MRE and MRFT are equivalent for distal SB distension and artefact effects. Proximal SB distension is frequently less optimal in MRFT than in MRE. MRE is, therefore, the preferred MR examination method of the SB. PMID: 19908338 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Lawrance IC, Welman CJ, Shipman P, Murray K Tags: World J Gastroenterol Source Type: journals

Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Investigating the coagulation cascade protein profiles during liver regeneration by DH may help to better understand the basic biology of the liver under normal and pathological conditions. PMID: 19908339 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Tatsumi K, Ohashi K, Taminishi S, Takagi S, Utoh R, Yoshioka A, Shima M, Okano T Tags: World J Gastroenterol Source Type: journals

Sickle cell cholangiopathy: An endoscopic retrograde cholangiopancreatography evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Considering the high frequency of biliary sludge and bile duct stones in SCD, endoscopic sphincterotomy might prove helpful in these patients. PMID: 19908340 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Issa H, Al-Haddad A, Al-Salem A Tags: World J Gastroenterol Source Type: journals

Celiac disease in patients with presumed irritable bowel syndrome: A case-finding study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CD is common in patients with presumed IBS. Routine screening for CD in patients with symptoms of IBS is recommended. PMID: 19908341 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Jadallah KA, Khader YS Tags: World J Gastroenterol Source Type: journals

Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A 7-feature, 15-point histological scoring system had good diagnostic accuracy in the interpretation of liver histology in neonatal cholestasis. PMID: 19908342 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Lee WS, Looi LM Tags: World J Gastroenterol Source Type: journals

Synergistic effect of fatty liver and smoking on metabolic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components, especially for hypertriglyceridemia and low serum HDL-C. PMID: 19908343 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Chiang PH, Chang TY, Chen JD Tags: World J Gastroenterol Source Type: journals

CDH1 promoter polymorphism (-347G-->GA) is a possible prognostic factor in sporadic colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The -347G-->GA promoter polymorphism in E-cadherin gene is associated with specific CRC features, and may be a prognostic factor rather than a susceptibility factor during the progression of CRC. PMID: 19908344 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Zou XP, Dai WJ, Cao J Tags: World J Gastroenterol Source Type: journals

Radical resection and outcome for malignant tumors of the pancreatic body and tail.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early diagnosis is crucial for increasing the radical resection rate, and radical resection plays an important role in improving survival for pancreatic body and tail cancer patients. PMID: 19908345 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Han SL, Zhang WJ, Zheng XF, Shen X, Zeng QQ, Ke QH Tags: World J Gastroenterol Source Type: journals

Effectiveness and safety of splenectomy for gastric carcinoma: A meta-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Splenectomy did not show a beneficial effect on survival rates compared to splenic preservation. Routinely performing splenectomy should not be recommended. PMID: 19908346 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Yang K, Chen XZ, Hu JK, Zhang B, Chen ZX, Chen JP Tags: World J Gastroenterol Source Type: journals

Liver abscess and sepsis with Bacillus pantothenticus in an immunocompetent patient: A first case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bacillus species are aerobic, gram-positive, spore forming rods that are usually found in the soil, dust, streams, and other environmental sources. Except for Bacillus. anthracis (B. anthracis), most species display low virulence, and only rarely cause infections in hosts with weak or damaged immune systems. There are two case reports of B. cereus as a potentially serious bacterial pathogen causing a liver abscess in an immunologically competent patient. We herein report a case of liver abscess and sepsis caused by B. pantothenticus in an immunocompetent patient. Until now, no case of liver abscess due to B. pantothent...
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Na JS, Kim TH, Kim HS, Park SH, Song HS, Cha SW, Yoon HJ Tags: World J Gastroenterol Source Type: journals

Novel mutations in the STK11 gene in Thai patients with Peutz-Jeghers syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study has expanded the genotypic spectrum of the STK11 gene. PMID: 19908348 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Ausavarat S, Leoyklang P, Vejchapipat P, Chongsrisawat V, Suphapeetiporn K, Shotelersuk V Tags: World J Gastroenterol Source Type: journals

A latent form of essential thrombocythemia presenting as portal cavernoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Essential thrombocythemia is frequently associated with abdominal thrombotic complications including portal cavernoma as a consequence of chronic portal vein thrombosis. Essential thrombocythemia in a latent form is difficult to identify at onset due to the absence of an overt disease phenotype. In the presented case report, the diagnosis of essential thrombocythemia was initially missed because the typical disease phenotype was masked by bleeding and hypersplenism. The correct diagnosis was only reached when the patient experienced persistent thrombocytosis and pseudohyperkalemia after a shunt operation. PMID: 199...
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Cai XY, Zhou W, Hong DF, Cai XJ Tags: World J Gastroenterol Source Type: journals

Hepatocellular carcinoma and evidence-based surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transplantation cannot be considered the most important therapeutic procedure for hepatocellular carcinoma (HCC). In France, no more than 2% of patients with HCC undergo a transplantation. Randomized controlled trial must assess the benefit to risk ratio of various potentially "curative" treatment procedures (transplantation, resection, radio-frequency ablation). PMID: 19908350 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Braillon A Tags: World J Gastroenterol Source Type: journals

Pernicious anemia: new insights from a gastroenterological point of view.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B(12) deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damage are increased fasting gastrin and decreased pepsinogen I. Without performing Schilling's test, intrinsic factor deficiency may not be proven, and intrinsic factor and parietal cell antibodies are useful surrogate markers of PA, with 73% sensitivity and 100% specificity. PA is mainly considered a disease ...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Lahner E, Annibale B Tags: World J Gastroenterol Source Type: journals

Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis C virus (HCV)-specific CD8(+) T cells play an important role in the resolution of HCV infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions and fail to control the virus. HCV has developed several mechanisms to escape immune control. One of these strategies is the up-regulation of negative co-stimulatory molecules such us programmed death-1 (PD-1). This molecule is up-regulated on intrahepatic and peripheral HCV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HCV-specific CD...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Larrubia JR, Benito-Martínez S, Miquel J, Calvino M, Sanz-de-Villalobos E, Parra-Cid T Tags: World J Gastroenterol Source Type: journals

Metabolic syndrome and risk of subsequent colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The metabolic syndrome and visceral obesity have an increasing prevalence and incidence in the general population. The actual prevalence of the metabolic syndrome is 24% in US population and between 24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES III, INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in t...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Pais R, Silaghi H, Silaghi AC, Rusu ML, Dumitrascu DL Tags: World J Gastroenterol Source Type: journals

EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: EP4-selective agonist may prevent indomethacin-induced gastric lesions and promote healing of existing and indomethacin-aggravated gastric ulcers, via promoting proliferation and survival of mucous epithelial cells. PMID: 19891013 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Jiang GL, Im WB, Donde Y, Wheeler LA Tags: World J Gastroenterol Source Type: journals

Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE. PMID: 19891014 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Miese FR, Wittsack HJ, Kircheis G, Holstein A, Mathys C, Mödder U, Cohnen M Tags: World J Gastroenterol Source Type: journals

Direct hepatic differentiation of mouse embryonic stem cells induced by valproic acid and cytokines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Hepatic cells of different developmental stages from early progenitors to matured hepatocytes can be acquired in the appropriate order based on sequential induction with VPA and cytokines. PMID: 19891015 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Dong XJ, Zhang GR, Zhou QJ, Pan RL, Chen Y, Xiang LX, Shao JZ Tags: World J Gastroenterol Source Type: journals

Modification of sleep architecture in an animal model of experimental cirrhosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These data suggest that hepatic failure produced by CCl(4) administration is capable of modifying the sleep pattern even after only a few doses. PMID: 19891016 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Jiménez-Anguiano A, Díaz-Medina V, Farfán-Labonne BE, Giono-Chiang G, Kersenobich D, García-Lorenzana M, Gutiérrez-Ruiz MC, Velázquez-Moctezuma J Tags: World J Gastroenterol Source Type: journals

Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of beneficial effects of CAPE before clinical usage of this agent. PMID: 19891017 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Buyukberber M, Savaş MC, Bagci C, Koruk M, Gulsen MT, Tutar E, Bilgic T, Ceylan NO Tags: World J Gastroenterol Source Type: journals

CO(2) insufflation for potentially difficult colonoscopies: efficacy when used by less experienced colonoscopists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CO(2) insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs. PMID: 19891018 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Uraoka T, Kato J, Kuriyama M, Hori K, Ishikawa S, Harada K, Takemoto K, Hiraoka S, Fujita H, Horii J, Saito Y, Yamamoto K Tags: World J Gastroenterol Source Type: journals

Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH. PMID: 19891019 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Kitade M, Yoshiji H, Noguchi R, Ikenaka Y, Kaji K, Shirai Y, Yamazaki M, Uemura M, Yamao J, Fujimoto M, Mitoro A, Toyohara M, Sawai M, Yoshida M, Morioka C, Tsujimoto T, Kawaratani H, Fukui H Tags: World J Gastroenterol Source Type: journals

Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study demonstrates that green tea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic fibrosis. PMID: 19891020 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Kim HK, Yang TH, Cho HY Tags: World J Gastroenterol Source Type: journals

Factors relating to the short term effectiveness of percutaneous biliary drainage for hilar cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival. PMID: 19891021 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Tsai HM, Chuang CH, Lin XZ, Chen CY Tags: World J Gastroenterol Source Type: journals

Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS. PMID: 19891022 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Ma XP, Tan LY, Yang Y, Wu HG, Jiang B, Liu HR, Yang L Tags: World J Gastroenterol Source Type: journals

Biloma: an unusual complication in a patient with pancreatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 64-year-old man initially diagnosed with a non-obstructive malignancy of the pancreas, who developed a spontaneous intrahepatic biloma 8 mo later. This was identified following a 1-wk history of fever, rigors and icterus. The biloma was identified on computed tomography and subsequently drained under ultrasound guidance. Forty-eight hours later, a stent was inserted endoscopically into his common bile duct and he made an uneventful in-hospital recovery. We believe this is the first documented case of spontaneous intrahepatic biloma to occur secondary to pancreatic malignancy. PMID: 19891023 [Pub...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Trivedi PJ, Gupta P, Phillips-Hughes J, Ellis A Tags: World J Gastroenterol Source Type: journals