Management of autoimmune hepatitis induced by hepatitis delta virus
World J Gastroenterol. 2024 Feb 28;30(8):799-805. doi: 10.3748/wjg.v30.i8.799.ABSTRACTApproximately 12-72 million people worldwide are co-infected with hepatitis B virus (HBV) and hepatitis delta virus (HDV). This concurrent infection can lead to several severe outcomes with hepatic disease, such as cirrhosis, fulminant hepatitis, and hepatocellular carcinoma, being the most common. Over the past few decades, a correlation between viral hepatitis and autoimmune diseases has been reported. Furthermore, autoantibodies have been detected in the serum of patients co-infected with HBV/HDV, and autoimmune features have been repo...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Eleni Gigi Vasileios Lagopoulos Aris Liakos Source Type: research

Adjuvant therapy for hepatocellular carcinoma: Dilemmas at the start of a new era
World J Gastroenterol. 2024 Feb 28;30(8):806-810. doi: 10.3748/wjg.v30.i8.806.ABSTRACTApproximately 50%-70% of patients with hepatocellular carcinoma experience recurrence within five years after curative hepatic resection or ablation. As a result, many patients receive adjuvant therapy after curative resection or ablation in order to prolong recurrence-free survival. The therapy recommended by national guidelines can differ, and guidelines do not specify when to initiate adjuvant therapy or how long to continue it. These and other unanswered questions around adjuvant therapies make it difficult to optimize them and determ...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Jian-Hong Zhong Source Type: research

Cronkhite-Canada syndrome with esophagus involvement and six-year follow-up: A case report
CONCLUSION: Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical symptoms. Treatment should be individualized for each patient according to their therapy response. Surveillance endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.PMID:38516236 | PMC:PMC10950646 | DOI:10.3748/wjg.v30.i8.984 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Yu-Chen Tang Source Type: research

Immunotherapy of gastric cancer: Present status and future perspectives
We describe the treatment of resectable tumors, locally advanced neoplasms, and unresectable (advanced) cases. Special attention is given to modern therapeutic approaches with emphasis on immunotherapy, which seems to be the future of GC treatment, especially in combination with chemotherapy. There is also a thorough analysis of the results of the study under review in terms of the number of scientific publications, the countries in which the studies were conducted, the authors, and the scientific centers of origin, as well as the clinical studies in progress. Finally, an attempt is made to draw some con-clusions and to po...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: John K Triantafillidis Manousos M Konstadoulakis Apostolos E Papalois Source Type: research

Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor
CONCLUSION: The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.PMID:38516238 | PMC:PMC10950641 | DOI:10.3748/wjg.v30.i8.863 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Gui-Ming Deng Hai-Bin Song Zhong-Ze Du Ying-Wei Xue Hong-Jiang Song Yuan-Zhou Li Source Type: research

Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023
CONCLUSION: Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field's dynamic growth.PMID:38516239 | PMC:PMC10950634 | DOI:10.3748/wjg.v30.i8.969 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Kai-Lin Jiang Yue-Bo Jia Xue-Jiao Liu Qing-Ling Jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang Jiang-Hong Ling Source Type: research

Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus
CONCLUSION: A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types I-IV.PMID:38516240 | PMC:PMC10950640 | DOI:10.3748/wjg.v30.i8.843 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Hong-Xiao Wu Xiao-Yan Ding Ya-Wen Xu Ming-Hua Yu Xiao-Mi Li Na Deng Jing-Long Chen Source Type: research

Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease: Mechanism, clinical evidence, and prospect
World J Gastroenterol. 2024 Feb 28;30(8):833-842. doi: 10.3748/wjg.v30.i8.833.ABSTRACTThe population of non-alcoholic fatty liver disease (NAFLD) patients along with relevant advanced liver disease is projected to continue growing, because currently no medications are approved for treatment. Fecal microbiota transplantation (FMT) is believed a novel and promising therapeutic approach based on the concept of the gut-liver axis in liver disease. There has been an increase in the number of pre-clinical and clinical studies evaluating FMT in NAFLD treatment, however, existing findings diverge on its effects. Herein, we briefly...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Xiao-Xia Qiu Sheng-Li Cheng Yan-Hui Liu Yu Li Rui Zhang Nan-Nan Li Zheng Li Source Type: research

Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma
CONCLUSION: High levels of MTDH expression in patients with HCC are associated with poor prognosis, promoting tumor stemness, immune infiltration, and HCC progression.PMID:38516242 | PMC:PMC10950638 | DOI:10.3748/wjg.v30.i8.901 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Yi-Ying Wang Mei-Mei Shen Jian Gao Source Type: research

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma
CONCLUSION: LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients, and the discovery of a novel LMR-lncRNAs, RP11-817I4.1, revealed its role in promoting lipid accumulation, thereby accelerating the onset and progression of HCC.PMID:38516243 | PMC:PMC10950635 | DOI:10.3748/wjg.v30.i8.919 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Ren-Yong Wang Jia-Ling Yang Ning Xu Jia Xu Shao-Hua Yang Dao-Ming Liang Jin-Ze Li Hong Zhu Source Type: research

Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in < em > Helicobacter pylori < /em > -infected patients
CONCLUSION: Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with H. pylori infection were at lower risk. IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H. pylori infection; however, metabolic syndrome increased the risk of patients with H. pylori infection developing reflux esophagitis.PMID:38516244 | PMC:PMC10950645 | DOI:10.3748/wjg.v30.i8.855 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Li-Hui Wang Bin-Bin Su Sheng-Shu Wang Guan-Chao Sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen Source Type: research

Prevalence and clinical impact of sarcopenia in liver transplant recipients: A meta-analysis
CONCLUSION: Sarcopenia is prevalent in a substantial proportion of patients undergoing LT and is strongly and independently associated with higher a risk of mortality risk.PMID:38516245 | PMC:PMC10950632 | DOI:10.3748/wjg.v30.i8.956 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Min-Jie Jiang Mu-Chen Wu Zhong-Hui Duan Jing Wu Xiao-Tong Xu Juan Li Qing-Hua Meng Source Type: research

Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment
World J Gastroenterol. 2024 Feb 28;30(8):794-798. doi: 10.3748/wjg.v30.i8.794.ABSTRACTIn this editorial we comment on the article published "Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment". Small bowel adenocarcinoma (SBA) is a rare gastrointestinal neoplasm and despite the small intestine's significant surface area, SBA accounts for less than 3% of such tumors. Early detection is challenging and the reason arises from its asymptomatic nature, often leading to late-stage discovery and poor prognosis. Treatment involves platinum-base...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Grigorios Christodoulidis Marina Nektaria Kouliou Konstantinos Eleftherios Koumarelas Source Type: research

Autoimmune pancreatitis: Cornerstones and future perspectives
World J Gastroenterol. 2024 Feb 28;30(8):817-832. doi: 10.3748/wjg.v30.i8.817.ABSTRACTAutoimmune pancreatitis (AIP) is an autoimmune subtype of chronic pancreatitis resulting from the aberrant immune response against the pancreas, leading to inflammation and fibrosis. Although AIP is rare, its incidence is increasing and is often misdiagnosed as other pancreatic diseases. AIP is commonly classified into two types. Type 1 AIP (AIP-1) is typically associated with elevated serum immunoglobulin G4 (IgG4) levels and systemic manifestations, while type 2 AIP is typically a more localized form of the disease, and may coexist with...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Camilla Gallo Giulia Dispinzieri Nicola Zucchini Pietro Invernizzi Sara Massironi Source Type: research

Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-on-chronic liver failure
CONCLUSION: The results indicated that bioenergetic alteration driven by hypoxia and mitochondrial dysfunction affects hepatic immune and metabolic remodeling, leading to advanced HBV-ACLF. These findings highlight a new therapeutic target for improving the treatment of HBV-ACLF.PMID:38516248 | PMC:PMC10950637 | DOI:10.3748/wjg.v30.i8.881 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Yu Zhang Xiao-Ling Tian Jie-Qun Li Dong-Sheng Wu Qiang Li Bin Chen Source Type: research