Multiprofessional Approach for Chronic Kidney Disease (CKD) Risk Reduction and Prophylaxis in the Kushiro Medical Area
Yakugaku Zasshi. 2024;144(2):151-155. doi: 10.1248/yakushi.23-00171.ABSTRACTChronic kidney disease (CKD) is closely related to disorders of various organs of the body and is also a factor in increasing social security costs such as medical costs for dialysis. Multiprofessional public health associations in Kushiro City jointly manage CKD-targeted action as "Kushiro CKD network" composed of medical/dental physicians, nurses, nutritionists and pharmacists. Pharmacists have played a central role in affixing a CKD sticker to a patient's medicine notebook when the patient's estimated glomerular filtration rate (eGFR) <45 mL/...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Taro Ooya Source Type: research

Epigenetic Regulation of Gene Expression and Hepatocyte Proliferation by Nuclear Receptor PPARA
Yakugaku Zasshi. 2024;144(2):157-161. doi: 10.1248/yakushi.23-00176.ABSTRACTChronic activation of the nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARA), causes hepatocellular proliferation and increases the incidence of hepatocellular carcinoma in rodents. However, the molecular mechanisms underlying hepatocyte proliferation by activated PPARA remain ambiguous. This review focuses on the genes repressed by PPARA and describes the mechanism by which it promotes hepatocyte proliferation in mice. PPARA undergoes autoinduction, leading to its overexpression by an agonist. PPARA subsequently activates t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Daisuke Aibara Source Type: research

Toward Elucidation of Human Health Effects of Micro/nanoplastics
Yakugaku Zasshi. 2024;144(2):163-164. doi: 10.1248/yakushi.23-00152-F.NO ABSTRACTPMID:38296492 | DOI:10.1248/yakushi.23-00152-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Yasuo Tsutsumi Hirofumi Tsujino Source Type: research

Preparation of Nanoplastic Particles as Potential Standards for the Study of Nanoplastics
Yakugaku Zasshi. 2024;144(2):165-170. doi: 10.1248/yakushi.23-00152-1.ABSTRACTNanoplastics (NPs) are plastic fragments that are small enough to be absorbed by organisms through ingestion or inhalation. Recent studies indicate that nanoplastics can be ubiquitous in the environment, and there are growing concerns regarding the impacts of nanoplastics on the health of humans and other organisms. However, quantitative information on nanoplastics in the environment is still very limited, and most previous toxicity studies have used only polystyrene (PS) particles because of a lack of appropriate model particles of other plastic...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Kosuke Tanaka Yusuke Takahashi Hidetoshi Kuramochi Masahiro Osako Go Suzuki Source Type: research

Dynamic Chemistry of Tannins
Yakugaku Zasshi. 2024;144(2):183-195. doi: 10.1248/yakushi.23-00170.ABSTRACTTannins are a group of polyphenols that possess the ability to precipitate proteins, causing an undesirable astringent taste by interacting with salivary peptides. This interaction deactivates the digestive enzymes; therefore, tannins are considered as plant defense substances. The health benefits of tannins and related polyphenols in foods and beverages have been demonstrated by biological and epidemiological studies; however, their metabolism in living plants and the chemical changes observed during processing of foods and medicinal herbs raises ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Takashi Tanaka Source Type: research

Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities
Yakugaku Zasshi. 2024;144(2):197-202. doi: 10.1248/yakushi.23-00174.ABSTRACTMy research focused on the effects of various drugs on (1) dopamine formation from p-tyramine catalyzed by polymorphic cytochrome P450 (CYP or P450) 2D6 variants and (2) endogenous steroid hormone hydroxylation catalyzed by CYP3A subfamily members (CYP3A4, CYP3A5, CYP3A7). The activation (cooperativity) of metabolic reactions catalyzed by P450s was especially emphasized. The effects of various psychotropic agents on dopamine formation from p-tyramine, catalyzed by wild-type CYP2D6.1 and CYP2D6 variants, including CYP2D6.2 (Arg296Cys;Ser486Thr), CYP...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Toshiro Niwa Source Type: research

Prevention and Treatment of Cancer with Vitamin A and Its Derivatives: Cell Differentiation and Proliferation
Yakugaku Zasshi. 2024;144(2):203-222. doi: 10.1248/yakushi.23-00184.ABSTRACTNormal differentiation and proliferation of cells are essential for maintaining homeostasis. Following the successful completion of whole genome sequencing, protein modification has been attracted increasing attention in order to understand the roles of protein diversification in protein function and to elucidate molecular targets in mechanisms of signal transduction. Vitamin A is an essential nutrient for health maintenance. It is present as β-carotene in green and yellow vegetables and retinyl ester in animal products and absorbed into the body ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Noriko Takahashi Source Type: research

Relationship between the Number of Pharmacists per Pharmacy and the Provision of Home Healthcare Services in Japan
This study examined the relationship between the number of pharmacists in each pharmacy and the provision of home healthcare services. The number of full-time and part-time pharmacists per pharmacy has a positive impact on the provision of home healthcare services. Moreover, the larger the number of pharmacists per pharmacy, the easier it is for the pharmacy to provide home healthcare services. With regard to pharmacies with one full-time pharmacist, there are more pharmacies that provide home healthcare services when the population density of municipalities where the pharmacy is located is high. However, the impact of the...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Midori Ueyama Hirofumi Tamaki Arihiro Osanai Yoko Ino Kazuya Nonomura Mari Iwata Toshiyuki Matsunaga Mitsuhiro Nakamura Kazuhiro Iguchi Source Type: research

Colitis Suggested to be Related to Nivolumab in a Gastric Cancer Patient with a History of Ulcerative Colitis: A Case Report
Yakugaku Zasshi. 2024;144(2):239-242. doi: 10.1248/yakushi.23-00167.ABSTRACTWe experienced a case in which long-term use of nivolumab in a patient with a history of ulcerative colitis led to disease control of gastric cancer. The case is a 77-year-old man. The patient had a history of ulcerative colitis and remained in remission on mesalazine 1500 mg/d. With continuous monitoring, nivolumab could be continued up to 16 courses, but was withdrawn due to the appearance of diarrhea (grade 1) and bloody stools, which was relieved with prednisolone (PSL) 40 mg/d. After two more courses, diarrhea (grade 3) appeared again, which i...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Tatsunori Ogawa Yuka Aimono Yoshiko Saito Takahiro Yagisawa Tatsuhiro Iwayama Akihiro Tamura Shinji Hirai Source Type: research

Preparation of Degraded Microplastics That Imitate Surface Properties in the Environment
In conclusion, this finding contributes to our understanding of the effects of polyethylene microplastics on the human body.PMID:38296494 | DOI:10.1248/yakushi.23-00152-2 (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Hirofumi Tsujino Yudai Ikuno Yuya Haga Haruyasu Asahara Kazuma Higashisaka Yasuo Tsutsumi Source Type: research

Mechanisms of Cell Toxicity Caused by Degraded Microplastics
Yakugaku Zasshi. 2024;144(2):177-181. doi: 10.1248/yakushi.23-00152-3.ABSTRACTMicroplastics (MPs), defined as plastic particles less than 5 mm in size, are ubiquitous in the environment. The accumulation of MPs in various environmental compartments, such as the ocean, soil, and air, has raised considerable concerns regarding their impact on ecological systems, including marine life and human health. Notably, MPs have been detected in marine organisms such as shellfish and fish, and have even been found in the human body, including in the blood and placenta. Moreover, considering that MPs have been detected in drinking wate...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Yuya Haga Sota Manabe Hirofumi Tsujino Haruyasu Asahara Kazuma Higashisaka Yasuo Tsutsumi Source Type: research

Multiprofessional Approach for Chronic Kidney Disease (CKD) Risk Reduction and Prophylaxis in the Kushiro Medical Area
Yakugaku Zasshi. 2024;144(2):151-155. doi: 10.1248/yakushi.23-00171.ABSTRACTChronic kidney disease (CKD) is closely related to disorders of various organs of the body and is also a factor in increasing social security costs such as medical costs for dialysis. Multiprofessional public health associations in Kushiro City jointly manage CKD-targeted action as "Kushiro CKD network" composed of medical/dental physicians, nurses, nutritionists and pharmacists. Pharmacists have played a central role in affixing a CKD sticker to a patient's medicine notebook when the patient's estimated glomerular filtration rate (eGFR) <45 mL/...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Taro Ooya Source Type: research

Epigenetic Regulation of Gene Expression and Hepatocyte Proliferation by Nuclear Receptor PPARA
Yakugaku Zasshi. 2024;144(2):157-161. doi: 10.1248/yakushi.23-00176.ABSTRACTChronic activation of the nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARA), causes hepatocellular proliferation and increases the incidence of hepatocellular carcinoma in rodents. However, the molecular mechanisms underlying hepatocyte proliferation by activated PPARA remain ambiguous. This review focuses on the genes repressed by PPARA and describes the mechanism by which it promotes hepatocyte proliferation in mice. PPARA undergoes autoinduction, leading to its overexpression by an agonist. PPARA subsequently activates t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Daisuke Aibara Source Type: research

Toward Elucidation of Human Health Effects of Micro/nanoplastics
Yakugaku Zasshi. 2024;144(2):163-164. doi: 10.1248/yakushi.23-00152-F.NO ABSTRACTPMID:38296492 | DOI:10.1248/yakushi.23-00152-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Yasuo Tsutsumi Hirofumi Tsujino Source Type: research

Preparation of Nanoplastic Particles as Potential Standards for the Study of Nanoplastics
Yakugaku Zasshi. 2024;144(2):165-170. doi: 10.1248/yakushi.23-00152-1.ABSTRACTNanoplastics (NPs) are plastic fragments that are small enough to be absorbed by organisms through ingestion or inhalation. Recent studies indicate that nanoplastics can be ubiquitous in the environment, and there are growing concerns regarding the impacts of nanoplastics on the health of humans and other organisms. However, quantitative information on nanoplastics in the environment is still very limited, and most previous toxicity studies have used only polystyrene (PS) particles because of a lack of appropriate model particles of other plastic...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 31, 2024 Category: Drugs & Pharmacology Authors: Kosuke Tanaka Yusuke Takahashi Hidetoshi Kuramochi Masahiro Osako Go Suzuki Source Type: research