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Reporting clinical trials: Why one plus one does not equal twoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest Thiboutot et al's November 2008 report of safety and efficacy of a product containing clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for treatment of acne. In the report, Thiboutot et al present combined data from two randomized controlled trials (RCTs) as if the two RCTs were in fact one large RCT. Unfortunately, such an approach is invalid. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: Kenneth A. Katz, Clara Y. Kim, Hywel C. Williams Tags: Notes & Comments Source Type: journals

The benzoxathiolone LYR-71 down-regulates interferon-γ-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and implications: Taken together, LYR-71 could restrain IFN-[gamma]-induced inflammatory responses through uncoupling the tyrosine phosphorylation of STAT-1, an activation index of JAK[ndash]STAT-1 signalling, in macrophages. These results may provide a molecular mechanism underlying anti-inflammatory actions shown by benzoxathiolone derivatives. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 18, 2009 Category: Drugs & Pharmacology Authors: E-Y Chung, B-H Kim, I-J Lee, E Roh, S-J Oh, J-A Kwak, Y-R Lee, B Ahn, S-Y Nam, S-B Han, Y Kim Source Type: journals

International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionThe feasibility of the study is considered to be very high because of its similar design to the EURAS-OC study. All relevant methodological and logistical features of the study were successfully tested in the EURAS study.The chosen design minimizes the impact of referral and misclassification bias, healthy user effect and loss to follow-up. Overall, it is expected that the study design is robust enough to interpret hazard ratios of 1.5 or higher. (Source: BioMed Central)
Source: BioMed Central - November 18, 2009 Category: Journals (General) Authors: Juergen DingerKristina BardenheuerAnita Assmann Source Type: journals

Effect of Smooth Pulsed Light at 400 to 700 and 870 to 1,200 nm for Acne Vulgaris in Asian SkinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intense pulsed light (IPL) treatment is effective for acne in Caucasians, but no significant improvements have been observed in studies on Asian skin. To evaluate the efficacy and safety of IPL on acne vulgaris in Asian skin. Twenty-five Japanese patients, mainly of skin phototypes III or IV and moderate to severe acne, were treated five times with IPL at wavelengths of 400 to 700 nm and 870 to 1,200 nm. Results were evaluated in terms of changes in numbers of noninflammatory comedones and inflammatory papules, pustules, and cysts and acne grade before and after treatment. After the first exposure, numbers of noninflammato...
Source: Dermatologic Surgery - November 13, 2009 Category: Dermatology Authors: SEIJI KAWANA, RIEKO TACHIHARA, TOKUE KATO, TOKUYA OMI Source Type: journals

Skin needling shows promise for improving acne scarsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin needling produces significant improvements in acne scarring, show results from a small, experimental study. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 13, 2009 Category: Dermatology Source Type: news

Controversial acne drug available in SAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While Americans have witnessed the sudden disappearance of a blockbuster acne drug, South Africans have no reason to worry. (Source: IOL: Health)
Source: IOL: Health - November 11, 2009 Category: African Health Source Type: news

New study may deal final blow to acne drug AccutaneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The study bolstered evidence of a link between the drug, pulled from the market in June, and inflammatory bowel disease. No medication is as effective in treating severe cases of acne. Teenagers and young adults suffering from severe, scarring acne may ultimately lose the most effective treatment for the condition. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - November 7, 2009 Category: Science Source Type: news

New study may deal final blow to acne drug AccutaneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The study bolstered evidence of a link between the drug, pulled from the market in June, and inflammatory bowel disease. No medication is as effective in treating severe cases of acne. Teenagers and young adults suffering from severe, scarring acne may ultimately lose the most effective treatment for the condition. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 7, 2009 Category: Consumer Health News Source Type: news

SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis and osteitis, is now recognized as a distinct medical entity, a reactive infectious osteitis. Genetic, immunological and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may rise due to non complete manifestations of SAPHO: acne and arthritis, or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assman et al. is a significant addition to a long range of publications, showing an association of SAPHO with P. acnes. Randomized control st...
Source: Arthritis Research and Therapy - November 5, 2009 Category: Rheumatology Authors: Alexander Rozin Source Type: journals

Acne: Causes, treatment and preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acne — Comprehensive overview covers causes, acne treatments, including adult acne treatments, and prevention. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - November 4, 2009 Category: Consumer Health News Source Type: news

Too old for acne? At 30, Rebecca thought she was past the age for spotsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adults acne is a growing problem. Occurring mostly in women, one recent study estimated that 14 per cent of those aged between 26 and 44 in the UK suffer from acne. (Source: the Mail online | Health)
Source: the Mail online | Health - November 3, 2009 Category: Consumer Health News Source Type: news

Skin Tightening Effect Using Fractional Laser Treatment: I. A Randomized Half-Side Pilot Study on Faces of Patients with AcneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fractional laser resurfacing is a new procedure for skin rejuvenation. To assess the skin remodeling effect of fractional laser treatment. Twelve Asian patients with acne were irradiated using a fractional 1,540-nm erbium glass laser on a random half of the face twice with a 4-week interval. The faces were contoured on the treated side of most patients. Statistical analyses of the facial images showed that the skin tightening effect was significant 4 weeks after the first and second irradiation (p (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - November 3, 2009 Category: Dermatology Authors: TERUKI DAINICHI, ATSUSHI KAWAGUCHI, SETSUKO UEDA, RIKIYA TAJIRI, TAKEAKI FUMIMORI, TATSUYUKI KAKUMA, TAKASHI HASHIMOTO Source Type: journals

Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Minimally ablative fractional laser devices have gained acceptance as a preferred method for skin resurfacing. Notable improvements in facial rhytides, photodamage, acne scarring, and skin laxity have been reported. The aim of the present work was to compare how different CO2 laser fluences, by modulating the secretory pathway of cytokines, are able to influence the wound-healing process, and how these fluences are associated with different clinical results. Eighteen patients, all with photodamaged skin, were treated using a fractional CO2 laser (SmartXide DOT, Deka M.E.L.A., Florence, Italy) with varying laser fluences (2...
Source: Dermatologic Therapy - November 3, 2009 Category: Dermatology Authors: F. Prignano, P. Campolmi, P. Bonan, F. Ricceri, G. Cannarozzo, M. Troiano, T. Lotti Tags: SIDeMaST Source Type: journals

Effaclar Acne Spot TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
La Roche-Posay's Effaclar AI Intensive Acne Spot Treatment is available to reduce stubborn and inflammatory acne in as few as 3 days. The formulation includes a 5.5% concentration of micronized benzoyl peroxide to clear inflammatory acne, as well as 0.4% LHA (lipohydroxy acid), which is a lipophilic derivative of salicylic acid that micro-exfoliates the skin and stimulates cell renewal to help even the skin tone, including residual skin marking. The product is oil free and noncomedogenic, and has been tested on sensitive skin. (Source: Skin and Allergy News)
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Tags: Products Source Type: journals

Personalized OTC Acne CareEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neutrogena's Skin ID regimen is available to treat and help prevent acne. The three-product, over-the-counter system is offered as an alternative to antibiotics for those who are concerned about building resistance to antibiotic treatments. Customers can complete an online skin evaluation that will direct them to a gel cleanser, an acne treatment, and a moisturizer “personalized” to fit their skin condition. The regimen includes salicylic acid, benzoyl peroxide, and a proprietary MicroClear technology to deliver the medication deep into pores; the system retails for about $40. (Source: Skin and Allergy News)
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Tags: Products Source Type: journals

Sun Defense Kit for Acne-Prone SkinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acne patients may be at increased risk for sun sensitivity and skin damage, depending on their treatment regimen. The Avidoxy DK defence kit offers products that provide sun protection for acne suffers without exacerbating their condition. The kit consists of 100-mg doxycycline tablets (available by prescription only) to help destroy acne-causing bacteria, plus two free products: defence acne wash and defence solare SPF 30. The acne wash contains 2% salicylic acid to promote cleansing and exfoliation, and it is oil-free and alcohol-free. The defence solare SPF is an oil-free, noncomedogenic, moisturizing sunblock that cont...
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Tags: Products Source Type: journals

Acne and Systemic DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acne is the most common skin disease. It normally occurs during adolescence as a result of excess production of hormones. However, acne may be associated with assorted endocrine disorders, nonendocrine diseases, and the use of certain medications. These causes of acne are discussed in this article along with basic therapeutic interventions. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - November 1, 2009 Category: Primary Care Authors: Margarita S. Lolis, Whitney P. Bowe, Alan R. Shalita Source Type: journals

Benzoyl peroxide and adapalene fixed combination: a novel agent for acne.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19857206 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 29, 2009 Category: Dermatology Authors: Layton AM, Eady EA Tags: Br J Dermatol Source Type: journals

ACG: Acne Drug Tied to IBD (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN DIEGO (MedPage Today) -- Use of the acne medication isotretinoin (Accutane) is associated with an increased risk of inflammatory bowel disease, researchers said here. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 29, 2009 Category: Gastroenterology Source Type: news

Acne vulgaris und Seborrhoe, Rosacea, Psoriasis vulgaris, Parapsoriasis, Lupus erythematodesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatologica 1948;95:91-101 (DOI:10.1159/000255936) (Source: Dermatology)
Source: Dermatology - October 28, 2009 Category: Dermatology Source Type: journals

Uncommon etiology of an anterior chest wall mass.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A rare but important constellation of musculoskeletal and cutaneous symptoms, including synovitis, acne, pustulosis, hyperostosis, and osteitis, has recently been designated the SAPHO syndrome. The exact etiology is unknown, although various infectious agents have been proposed. The most common site of osteoarticular involvement is the sternoclavicular joint, and therefore, recognition of this syndrome and appropriate workup and management is crucial in the differential diagnosis of an anterior chest wall mass. PMID: 19853079 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 27, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Schwartz GS, Rios L, Zivin-Tutela T, Bhora FY, Connery CP Tags: Ann Thorac Surg Source Type: journals

The individual health burden of acne: Appearance-related distress in male and female adolescents and adults with back, chest and facial acneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined appearance-related distress in patients with acne. One hundred and thirty-two people attending a specialist acne clinic completed questionnaires including the Derriford Appearance Scale and three self-rated acne scales covering more (facial) and less visible (chest, back) acne sites. Women with acne demonstrated greater self-consciousness of appearance and negative self-concept than men. Subjective rating of severity of facial acne was significantly associated with increased social self-consciousness in women, but not in men. Back acne was significantly associated with sexual and bodily self-consciousne...
Source: Journal of Health Psychology - October 26, 2009 Category: Psychiatry & Psychology Authors: Hassan, J., Grogan, S., Clark-Carter, D., Richards, H., Yates, V. M. Tags: Articles Source Type: journals

Acne in women: clinical patterns in different age-groupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Chronologic and topographic patterns of female acne in different age-groups were defined, reinforcing the importance of an individualized diagnostic and therapeutic approach. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - October 23, 2009 Category: Dermatology Source Type: journals

Management of acne vulgaris: an evidence-based updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. R. Ingram, D. J. C. Grindlay, H. C. Williams Source Type: journals

Immune reconstitution inflammatory syndrome involving the skinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. New skin lesions were very common in this cohort, with the majority being women and patients with very low baseline CD4 counts. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: B. Osei-Sekyere, A. S. Karstaedt Source Type: journals

Uncommon Etiology of an Anterior Chest Wall Mass [CASE REPORTS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A rare but important constellation of musculoskeletal and cutaneous symptoms, including synovitis, acne, pustulosis, hyperostosis, and osteitis, has recently been designated the SAPHO syndrome. The exact etiology is unknown, although various infectious agents have been proposed. The most common site of osteoarticular involvement is the sternoclavicular joint, and therefore, recognition of this syndrome and appropriate workup and management is crucial in the differential diagnosis of an anterior chest wall mass. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 22, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Schwartz, G. S., Rios, L., Zivin-Tutela, T., Bhora, F. Y., Connery, C. P. Tags: Chest wall CASE REPORTS Source Type: journals

With Microdermabrasion, Rough Seems to Work BetterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acne scars and wrinkles benefit from more aggressive treatment, study finds Source: HealthDay Related MedlinePlus Topic: Plastic and Cosmetic Surgery (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 21, 2009 Category: Consumer Health News Source Type: consumer

RESEARCH LETTERS: Physician Workforce for Acne Care in the United States, 2003 Through 2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Dermatology)
Source: Archives of Dermatology - October 19, 2009 Category: Dermatology Authors: Armstrong, A. W., Idriss, N., Bergman, H. Tags: Dermatology, Dermatologic Disorders, acne, Pediatrics, Pediatrics, Other, Primary Care/ Family Medicine, Dermatology, Other Research Letters Source Type: journals

Physician Workforce for Acne Care in the United States, 2003 Through 2005 [Research Letters]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Archives of Dermatology)
Source: Archives of Dermatology - October 19, 2009 Category: Dermatology Authors: Armstrong, A. W., Idriss, N., Bergman, H. Tags: Dermatology, Dermatologic Disorders, acne, Pediatrics, Pediatrics, Other, Primary Care/ Family Medicine, Dermatology, Other Research Letters Source Type: journals

Dusa targets skin cancer to blunt downturn’s effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The downturn has been particularly cruel to laser dermatology companies, which often rely on nonessential treatments that patients must pay for out of pocket. Companies with laser treatments for acne, hair removal and the like have faced the double whammy of patients tightening purse strings and doctors who are hamstrung by the credit crunch and can’t purchase the latest equipment. (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - October 19, 2009 Category: American Health Source Type: journals

Dusa targets skin cancer to blunt downturn’s effectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The downturn has been particularly cruel to laser dermatology companies, which often rely on nonessential treatments that patients must pay for out of pocket. Companies with laser treatments for acne, hair removal and the like have faced the double whammy of patients tightening purse strings and doctors who are hamstrung by the credit crunch and can’t purchase the latest equipment. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 19, 2009 Category: Biotechnology Source Type: journals

A case of SAPHO syndrome with destructive spondylodiscitis suspicious of tuberculous spondylitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in which the differential diagnosis included tuberculous spondylitis and the patient ultimately required reconstructive spinal surgery. The patient was a 60-year-old woman who presented with severe low-back and leg pain after treatment for tuberculosis. Roentgenography and magnetic resonance imaging of the lumbar spine revealed destructive changes suggestive of tuberculous spondylitis. [18F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography showed uptake in the cervical spines, lumbar spines, and sacroilia...
Source: Modern Rheumatology - October 15, 2009 Category: Rheumatology Tags: Modern Rheumatology Source Type: journals

II. Zur Kenntnis der Pathogenese der Perifolliculitis capitis abscedens et suffodiens (E. Hoffmann) und ihrer Beziehungen zur Acne conglobataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatologische Zeitschrift 1928;51:94-107 (DOI:10.1159/000251817) (Source: Dermatology)
Source: Dermatology - October 14, 2009 Category: Dermatology Source Type: journals

Natural remedies for acneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Acne sucks. But you don't need antibiotics or harsh chemicals to treat it. In addition to altering your diet so that you consume fewer acne-producing foods (dairy products and fried foods, mostly), there are some effective natural remedies that are also useful for clearing up your skin.Below, we've compiled a few of these recommendations from some of the top authors in natural health. Enjoy this short collection, and feel free to share it with others (please give appropriate credit to the original author as well as this NaturalNews page, thank you).Natural remedies for acneBrazilian school kids have acne. The...
Source: NaturalNews.com - October 14, 2009 Category: Consumer Health Advice Source Type: news

Quality of Sexual Life in Hyperandrogenic Women Treated with an Oral Contraceptive Containing Chlormadinone AcetateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s). The EE/CMA pill has anti-androgenic properties reducing the anti-aesthetic effect of hyperandrogenism and improving female sexual and social self-esteem. Caruso S, Rugolo S, Agnello C, Romano M, and Cianci A. Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)
Source: The Journal of Sexual Medicine - October 13, 2009 Category: Sexual Medicine Authors: Salvatore Caruso, Salvatore Rugolo, Carmela Agnello, Mattea Romano, Antonio Cianci Source Type: journals

New Study Assesses Skin Hydration And Epidermal Function Of 2.5% And 5% Benzoyl Peroxide-Clindamycin CombinationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Las Vegas, NV – October 15, 2009 – Dermatologists agree that topical fixed-combination products containing clindamycin (clin) and benzoyl peroxide (BPO) are effective in the treatment of acne. However, products containing BPO... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 13, 2009 Category: Pharmaceuticals Source Type: clinical trials

Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The synbiotic ability of probiotic bacteria and konjac glucomannan hydrolysates (GMH) to inhibit acne-inducing bacterium, Propionibacterium acnes growth was studied in vitro. All probiotic bacteria strains tested were able to inhibit the growth of this species of skin bacterium where the inhibition was significantly (P < 0.01) enhanced by the presence of the GMH prebiotic. As the current treatment of acne is based on topical or systemic drugs, it is worth examining further the biotherapeutic activities of the GMH and selected probiotics with a view to future use as prophylactic or therapeutic synbiotics for treating acne i...
Source: International Journal of Cosmetic Science - October 10, 2009 Category: Dermatology Authors: F. H. Al-Ghazzewi, R. F. Tester Source Type: journals

Antibiotics Control SAPHO Syndrome, but Symptoms Recur When Therapy StopsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although SAPHO syndrome - which stands for synovitis, acne, pustulosis, hyperostosis, and osteomyelitis - responds to antibiotics, discontinuing the medication leads to relapse, German researchers report in the September 21st online issue of Arthritis Research and Therapy. Reuters Health Information (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - October 8, 2009 Category: Rheumatology Tags: Rheumatology Source Type: info

New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propioni...
Source: Current Rheumatology Reports - October 6, 2009 Category: Rheumatology Tags: Current Rheumatology Reports Source Type: journals

Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-κB and MAPK pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that nicotinamide inhibits IL-8 production through the NF-κB and MAPK pathways in an in vitro keratinocytes/P. acnes model of inflammation. Keratinocytes involved in the innate immune response may be a suitable target for treatment during the early phase of inflammation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2009 Category: Dermatology Authors: Philippe A. Grange, Joël Raingeaud, Vincent Calvez, Nicolas Dupin Tags: Regular articles Source Type: journals

Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions On the basis of our findings, we propose using a patient questionnaire and protocol for investigating and managing patients who present with NBO to orthopedic surgeons. We predict that this will benefit patients with this disorder by improving our knowledge of the presenting signs and symptoms and related disorders, rationalizing the therapeutic approach, and allowing us to learn about the natural history of the disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-009-1381-4Authors Panagiotis D. Gikas, Bone Tumour Unit, Royal National Orthopaedic Hospital Stanm...
Source: Journal of Orthopaedic Science - October 3, 2009 Category: Orthopaedics Tags: Journal of Orthopaedic Science Source Type: journals

11. Acne, Psoriasis, and Disorders of KeratinizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s00533-009-0166-2 Journal Medical and Surgical DermatologyOnline ISSN 1934-2853Print ISSN 0944-5196 (Source: Medical and Surgical Dermatology)
Source: Medical and Surgical Dermatology - October 3, 2009 Category: Dermatology Tags: Medical and Surgical Dermatology Source Type: journals

50 years ago from the Connecticut State Medical Journal. October 1959. Radiation therapy of acne.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19860280 [PubMed - in process] (Source: Connecticut Medicine)
Source: Connecticut Medicine - October 1, 2009 Category: Journals (General) Authors: Strauss JS Tags: Conn Med Source Type: journals

Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Photodynamic therapy of acne vulgaris using 5-ALA 0.5% liposomal spray and IPL in combination with topical peeling agents is safe and efficacious, even in patients with acne recalcitrant to standard therapy. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - September 30, 2009 Category: Dermatology Authors: J de Leeuw, N van der Beek, P Bjerring, HA Martino Neumann Source Type: journals

[Pandalao and skin whitening in Mayotte.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: Although illegal, the trade in skin whitening products continues to grow because it is profitable and takes full advantage of the success of ethnic cosmetics. In Mayotte, as in metropolitan France and Africa, the existence of SW is acknowledged but is still taboo. However, a number of specific characteristics are seen in Mayotte: SW is rarely performed on the whole body, salicylic acid is added to a topical corticosteroid, and the traditional Mahoran mask, the "mzindzano", is still worn for photoprotection. PMID: 19801250 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - September 30, 2009 Category: Dermatology Authors: Levang J, Eygonnet F, Humbert P Tags: Ann Dermatol Venereol Source Type: journals

Multimodal Treatment of Acne, Acne Scars and PigmentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the causes of acne, the treatment options, and grading scales. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 30, 2009 Category: Dermatology Authors: Ava T. Shamban, Vic A. Narurkar Source Type: journals

Nonablative Fractional Laser ResurfacingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discussed the science, clinical indications, patient selection and preparation, posttreatment care, and complications of NFR. It concludes that the most impressive clinical results are seen with acne scars, surgical and traumatic scars, and mild to moderate facial and nonfacial dyschromia or photoaging. Modest results can be seen with therapy-resistant melasma and certain types of rhytides. Future approaches include synergistic treatments with radiofrequency devices and the development of novel wavelengths to enhance the efficacy of NFR while preserving safety. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - September 30, 2009 Category: Dermatology Authors: Vic A. Narurkar Source Type: journals

Emerging Technologies in Aesthetic MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent advances in technology have drastically improved aesthetic treatment for skin. Of particular interest is the emergence of laser- and lightbased technologies, which have offered great promise among skin-rejuvenation therapies. New laser resurfacing techniques for skin rejuvenation offer significant advantages over conventional ablative lasers, such as the CO2 and erbiumYAG laser systems. Nonablative and fractional lasers, although not as efficacious as ablative therapies, are associated with significantly diminished complication rates and shortened recovery times. Novel devices combining ablative and fractional techn...
Source: Dermatologic Clinics - September 30, 2009 Category: Dermatology Authors: Bobby Y. Reddy, Basil M. Hantash Source Type: journals

Health advice: 'Is there a cure for a son who's uncommunicative and sullen?'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Britain's leading health and wellbeing specialists answer your questions: This week: an uncommunicative son. (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - September 30, 2009 Category: Consumer Health Advice Tags: health advice health q & wellbeing teenagers uncommunicative son drugs acne depression Source Type: consumer

Fact Checking Anecdotes: Obama Wrong On Particulars In Cancer And Acne Insurance Denial CaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When President Obama recently recounted the story of a woman he said was denied coverage for failure to own up to a skin condition when she enrolled in a plan, he was incorrect, The Associated Press reports. "Robin Lynn Beaton, 59, of Waxahachie, Texas, indeed had her insurance suspended and then terminated when she needed it the most. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 30, 2009 Category: Consumer Health News Tags: Health Insurance / Medical Insurance Source Type: news