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Perturbation of protein metabolism in acromegalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Oral PresentationsDOI 10.1007/BF03170264Authors J. Gibney, Garvan Institute of Medical Research Pituitary Research Unit IrelandT. Wolthers, Garvan Institute of Medical Research Pituitary Research Unit IrelandM. Males, Garvan Institute of Medical Research Pituitary Research Unit IrelandG. Smythe, University of New South Wales Biomedical Mass Spectrometry Facility AustraliaA. M. Umpleby, GKT School of Medicine, St Thomas’s Hospital Department of Diabetes and Endocrinology London UKK. K. Y. Ho, Garvan Institute of Medical Research Pituitary Research Unit Ireland Journal Irish ...
Source: Irish Journal of Medical Science - November 17, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

AcromegalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - November 16, 2009 Category: Journals (General) Source Type: info

Focal Neuronal Gigantism: A Rare Complication of Therapeutic Radiation [BRAIN]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report this rare delayed complication in a patient following treatment of a right frontal anaplastic oligodendroglioma. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Gaughen, J.R., Bourne, T.D., Aregawi, D., Shah, L.M., Schiff, D. Tags: BRAIN Source Type: journals

Aftercare in patients with Cushing’s disease and acromegaly: is there room for improvement?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The postoperative transfer back to the endocrinologist after operative treatment is achieved well in both groups. In uncured AC, medical therapy is initiated early, but options of therapy offer room for improvement. Therapy of recurrence is delayed in both pathologies. Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0544-6Authors Tsambika Psaras, University of Tuebingen Department of Neurosurgery Hoppe-Seyler-Strasse 3 72076 Tuebingen GermanyMonika Milian, University of Tuebingen Department of Neurosurgery Hoppe-Seyler-Strasse 3 72076 Tuebingen GermanyValerie Ha...
Source: Acta Neurochirurgica - November 12, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Acromegaly with negative pituitary MRI and no evidence of ectopic source: the role of transphenoidal pituitary exploration?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with acromegaly and an unremarkable pituitary MR imaging who had negative work up for ectopic growth hormone-releasing hormone (GHRH) or GH secreting tumors. Transsphenoidal pituitary exploration revealed a pituitary adenoma located on the left side of the sella against the medial wall of the cavernous sinus extending posteriorly along the floor of the sella all the way to the right side. The acromegaly was treated with resection of the pituitary adenoma and normalization of serum insulin-like growth factor 1 (IGF-1) and GH levels. In a patient with acromegaly and unremarkable pituitary MR imaging,...
Source: Pituitary - November 10, 2009 Category: Endocrinology Tags: Pituitary Source Type: journals

Effectiveness of self- or partner-administration of an extended-release aqueous-gel formulation of lanreotide in lanreotide-naïve patients with acromegalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed the efficacy and safety of self- or partner-administration of lanreotide in patients with acromegaly. This was a six-month, single-arm, open-label study conducted at 13 endocrinology clinics. Fifty-nine patients received deep subcutaneous lanreotide injections every 28 days. Twelve patients started on 120 mg lanreotide and forty-seven started on 90 mg lanreotide. At week 16, the dose was adjusted to 60, 90 or 120 mg based on insulin-like growth factor-1 (IGF-1) levels at week 12. Fifty-nine patients with acromegaly either switched from long-acting octreotide (switch; n =&nb...
Source: Pituitary - November 7, 2009 Category: Endocrinology Tags: Pituitary Source Type: journals

Gamma knife in acromegalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ronchi and colleagues evaluate the efficacy of gamma knife radiosurgery in a large series of acromegalic patients over a 10 year monitoring period. High cure rates and adequate control with low side effects – such as visual impairment or recurrence – was tempered with an increase in novel pituitary deficiencies in 50% of the patient group such as hypoadrenalism. Ronchi et al., Clinical Endocrinology, DOI:10.1111/j.1365-2265.2009.03589.x (Source: Society for Endocrinology)
Source: Society for Endocrinology - November 4, 2009 Category: Endocrinology Source Type: organizations

Evolution of an Aggressive Prolactinoma into a Growth Hormone Secreting Pituitary Tumor Coincident with GNAS Gene Mutation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These observations suggest that 1)treatment of prolactinomas resistant to dopaminergic drugs is still a challenge, and 2) the appearance of gsp oncogene in a prolactinoma evolving into acromegaly might be the underlying mechanism of this rare transition, further confirming that this mutational change is associated with somatotroph growth and transformation. PMID: 19890024 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Lania AG, Ferrero S, Pivonello R, Mantovani G, Peverelli E, Di Sarno A, Beck Peccoz P, Spada A, Colao A Tags: J Clin Endocrinol Metab Source Type: journals

Acromegaly pathogenesis and treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting pituitary adenoma and leads to acromegaly — a disorder of disproportionate skeletal, tissue, and organ growth. High GH and IGF1 levels lead to comorbidities including arthritis, facial changes, prognathism, and glucose intolerance. If the condition is untreated, enhanced mortality due to cardiovascular, cerebrovascular, and pulmonary dysfunction is associated with a 30% decrease in life span. This Review discusses acromegaly pathogenesis and management options. The latter include surgery, radiation, and use of novel medications. Som...
Source: Journal of Clinical Investigation - November 3, 2009 Category: Biomedical Science Authors: Shlomo Melmed Source Type: journals

Chlorella minutissima-A Promising Fuel Alga for Cultivation in Municipal Wastewaters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is imperative to slash the cost of algal oil to less than $50 bbl(-1) for successful algal biofuel production. Use of municipal wastewater for algal cultivation could obviate the need for freshwater and the nutrients-N and P. It would also add CO(2) through bacterial activity. Chlorella minutissima Fott et Nova dominated the entire phycoflora year around and through each stage of the wastewater treatment at the oxidation pond system of Wazirabad (Delhi) in India. The ability to grow so profusely in such varied and contrasting situations made this alga unique. Besides pollution tolerance, it grew heterotrophically in...
Source: Applied Biochemistry and Biotechnology - November 1, 2009 Category: Biochemistry Authors: Bhatnagar A, Bhatnagar M, Chinnasamy S, Das KC Tags: Appl Biochem Biotechnol Source Type: journals

The value of IGF1 estimation in adults with GH deficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The GH/IGF1 system, like other endocrine systems, is dynamic and its activity changes with age and sexual maturation, and is influenced by body composition and other factors. A normal level of IGF1 does not exclude a diagnosis of GH deficiency (GHD) in adults, and the usefulness of IGF1 in the diagnosis of adult GHD has historically been confusing and contentious. The regulation of IGF1 secretion in adults is complex, and is not solely dependent on GH status with factors recognized to influence IGF1 status in patients with GHD including age, gender, exogenous estrogen therapy, prolactin status, and severity of GHD. The...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Mukherjee A, Shalet SM Tags: Eur J Endocrinol Source Type: journals

Growth hormone isoforms in acromegalic patients before and after treatment with octreotide LAR.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our study confirmed that acromegalic patients have an increased proportion of circulating 20kDa-hGH isoform. Consequently, the use of a 22kDa-hGH specific assay may underestimate the tumor production of total GH. Although octreotide LAR promoted a significant decrease in the GH and IGF-I levels, it did not normalize the GH isoforms composition and suggests that the secretion of GH isoforms is equally inhibited by somatostatin analogues and that it is the disease control that normalizes the GH isoforms composition in acromegaly. PMID: 19884028 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - October 31, 2009 Category: Endocrinology Authors: Lima GA, Wu Z, Silva CM, Barbosa FR, Dias JS, Schrank Y, Strasburger CJ, Gadelha MR Tags: Growth Horm IGF Res Source Type: journals

Management of acromegaly in Latin America: expert panel recommendationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Although there are international guidelines orienting physicians on how to manage patients with acromegaly, such guidelines should be adapted for use in distinct regions of the world. A panel of neuroendocrinologists convened in Mexico City in August of 2007 to discuss specific considerations in Latin America. Of major discussion was the laboratory evaluation of acromegaly, which requires the use of appropriate tests and the adoption of local institutional standards. As a general rule to ensure diagnosis, the patient’s GH level during an oral glucose tolerance test and IGF-1 level should be evalua...
Source: Pituitary - October 30, 2009 Category: Endocrinology Tags: Pituitary Source Type: journals

Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data confirm and establish novel and complex interactions between bone, energy metabolism, and adipose tissue and suggest an unfavorable effect of OCN and GH/IGF-I in combination on insulin metabolism in active acromegaly. PMID: 19880791 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 30, 2009 Category: Endocrinology Authors: Ueland T, Fougner SL, Godang K, Lekva T, Schurgers LJ, Scholz H, Halvorsen B, Schreiner T, Aukrust P, Bollerslev J Tags: J Clin Endocrinol Metab Source Type: journals

Obstructive sleep apnea in a patient with the Melkersson-Rosenthal syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: To the best of our knowledge, this is the first report of OSA occurring in a patient with MRS. PMID: 19862566 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 28, 2009 Category: Sleep Medicine Authors: Eisele HJ, Reichenberger F, Mayer K, Weissmann N, Seeger W, Schulz R Tags: Sleep Breath Source Type: journals

The Exon-3 Deleted Growth Hormone Receptor Polymorphism Predisposes to Long-Term Complications of Acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In patients with long-term cured acromegaly, the d3GHR polymorphism is associated with an increased prevalence of irreversible comorbidities such as osteoarthritis, dolichocolon, and adenomatous colonic polyps, but not with other comorbidities such as cardiovascular risk factors. PMID: 19864451 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2009 Category: Endocrinology Authors: Wassenaar MJ, Biermasz NR, Pereira AM, van der Klaauw AA, Smit JW, Roelfsema F, van der Straaten T, Cazemier M, Hommes DW, Kroon HM, Kloppenburg M, Guchelaar HJ, Romijn JA Tags: J Clin Endocrinol Metab Source Type: journals

Hypertrophic Remodeling of Subcutaneous Small Resistance Arteries in Patients with Cushing's Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest the presence of hypertrophic remodeling in sc small resistance arteries of CS, probably as a consequence of growth-promoting properties of circulating cortisol and/or increased vascular oxidative stress. PMID: 19864447 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2009 Category: Endocrinology Authors: Rizzoni D, Porteri E, De Ciuceis C, Rodella LF, Paiardi S, Rizzardi N, Platto C, Boari GE, Pilu A, Tiberio GA, Giulini SM, Favero G, Rezzani R, Rosei CA, Bulgari G, Avanzi D, Rosei EA Tags: J Clin Endocrinol Metab Source Type: journals

Obstructive sleep apnea in a patient with the Melkersson–Rosenthal syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion To the best of our knowledge, this is the first report of OSA occurring in a patient with MRS. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11325-009-0309-8Authors Hans-Joachim Eisele, University of Giessen Lung Center Giessen GermanyFrank Reichenberger, University of Giessen Lung Center Giessen GermanyKonstantin Mayer, University of Giessen Lung Center Giessen GermanyNorbert Weissmann, University of Giessen Lung Center Giessen GermanyWerner Seeger, University of Giessen Lung Center Giessen GermanyRichard Schulz, University of Giessen Lung Center Giessen Germany Journal...
Source: Sleep and Breathing - October 27, 2009 Category: Respiratory Medicine Tags: Sleep and Breathing Source Type: journals

Medical Therapy of Acromegaly: Efficacy and Safety of Somatostatin AnaloguesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Drugs)
Source: Drugs - October 26, 2009 Category: Drugs & Pharmacology Authors: Feelders, Richard A.Hofland, Leo J.van Aken, Maarten O.Neggers, Sebastian J.Lamberts, Steven W.J.de Herder, Wouter W.Aart-Jan van der Lely, Tags: Review Articles Source Type: journals

The Exon 3-Deleted Growth Hormone Receptor Is Associated with Better Response to Pegvisomant Therapy in Acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The exon 3 deletion in the GHR predicts an improved response to pegvisomant therapy in acromegaly. PMID: 19850678 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 22, 2009 Category: Endocrinology Authors: Bernabeu I, Alvarez-Escolá C, Quinteiro C, Lucas T, Puig-Domingo M, Luque-Ram F8rez M, de Miguel-Novoa P, Fernandez-Rodriguez E, Halperin I, Loidi L, Casanueva FF, Marazuela M Tags: J Clin Endocrinol Metab Source Type: journals

EMEA grants orphan drug status for pasireotide for acromegaly and for Cushing's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: EMEA Area: News The European Commission has granted orphan drug designation for pasireotide for the treatment of acromegaly and the treatment of Cushing's disease. Pasireotide is a somatostatin analogue, a copy of the natural hormone somatostatin. Like somatostatin, pasireotide is expected to attach to somatostatin receptors, thus blocking the release of growth hormone. This may result in the reduction of the symptoms and complications of acromegaly. Somatostatin receptors are also found in high amounts in tumour cells, including tumours of the pituitary gland. By attaching to somatostatin re...
Source: NeLM - News - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Cope's Rule and Romer's theory: patterns of diversity and gigantism in eurypterids and Palaeozoic vertebrates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gigantism is widespread among Palaeozoic arthropods, yet causal mechanisms, particularly the role of (abiotic) environmental factors versus (biotic) competition, remain unknown. The eurypterids (Arthropoda: Chelicerata) include the largest arthropods; gigantic predatory pterygotids (Eurypterina) during the Siluro-Devonian and bizarre sweep-feeding hibbertopterids (Stylonurina) from the Carboniferous to end-Permian. Analysis of family-level originations and extinctions among eurypterids and Palaeozoic vertebrates show that the diversity of Eurypterina waned during the Devonian, while the Placodermi radiated, yet Stylonu...
Source: Biology Letters - October 13, 2009 Category: Biology Authors: Lamsdell JC, Braddy SJ Tags: Biol Lett Source Type: journals

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PEG is highly effective for improving patients' IGF-1 level. Signs and symptoms of disease improve but evidence is lacking about long term effects on improved signs and symptoms of disease, quality of life, patient compliance and safety. Economic evaluation indicated that if current standards (UK) for determining cost-effectiveness of therapies were to be applied to PEG it would be considered not to represent good value for money. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 7, 2009 Category: Endocrinology Authors: David MooreYaser AdiMartin ConnockSue Bayliss Source Type: journals

The current status of IGF-I assays - A 2009 update.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For almost three decades, the measurement of circulating IGF-I has constituted a highly important biochemical tool in the management of GH disorders. In fact, in acromegaly the importance of circulating IGF-I has increased following the introduction of the GH receptor antagonist pegvisomant, as the use of this drug makes it impossible to use circulating GH as a monitor of disease activity. In addition, determination of circulating IGF-I constitutes a valuable scientific tool in various research areas, from epidemiological investigations through clinical trials and experimental studies. The multiple facets of IGF-I phys...
Source: Growth Hormone and IGF Research - October 6, 2009 Category: Endocrinology Authors: Frystyk J, Freda P, Clemmons DR Tags: Growth Horm IGF Res Source Type: journals

ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Radiotherapy and ACTH deficiency are significantly associated with increased mortality in patients with acromegaly. In ACTH-deficient patients, a daily dose of more than 25 mg hydrocortisone is associated with increased mortality compared to lower doses. These results have important implications for the treatment of patients with acromegaly and also raise issues as to the optimum hydrocortisone treatment regimens for ACTH-deficient patients. PMID: 19808848 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 5, 2009 Category: Endocrinology Authors: Sherlock M, Reulen RC, Alonso AA, Ayuk J, Clayton RN, Sheppard MC, Hawkins MM, Bates AS, Stewart PM Tags: J Clin Endocrinol Metab Source Type: journals

Introduction: KIMS and ACROSTUDY Supplement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
KIMS and ACROSTUDY are two observational surveys (ObS) of treatment with growth hormone in adults with pituitary deficiency and growth hormone receptor blocker in patients with acromegaly respectively. Pro and cons of ObS versus randomized clinical trials are discussed in this paper as well as some introductury remarks of the papers in this supplement of EJE. PMID: 19808900 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 5, 2009 Category: Endocrinology Authors: Wilton P Tags: Eur J Endocrinol Source Type: journals

The Efficacy of Octreotide LAR as Firstline Therapy for Patients with Newly Diagnosed Acromegaly is Independent of Tumor Extension: Predictive Factors of Tumor and Biochemical ResponseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Horm Metab ResDOI: 10.1055/s-0029-1239506AbstractSurgical outcome of acromegaly depends on the preoperatory tumor size and extension. Somatostatin analogues are also a highly effective treatment for acromegalic patients. Nevertheless, the response of GH-secreting adenomas to primary medical therapy is variable. The aim of the present study was to evaluate the efficacy of octreotide LAR as primary therapy for acromegalic patients as a function of initial tumor extension. We performed a multicentre, prospective, observational and analytical study recruiting 19 “naive” acromegalic patients (5 microadenomas, 10 int...
Source: Hormone and Metabolic Research - October 2, 2009 Category: Endocrinology Tags: Humans, Clinical Source Type: journals

Discordant Nadir GH After Oral Glucose and IGF-I Levels on Treated Acromegaly: Refining the Biochemical Markers of Mild Disease ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Horm Metab ResDOI: 10.1055/s-0029-1239522AbstractBiochemical markers for remission on acromegaly activity are controversial. We studied a subset of treated acromegalic patients with discordant nadir GH levels after oral glucose tolerance test (oGTT) and IGF-I values to refine the current consensus on acromegaly remission. We also compared GH results by two GH immunoassays. From a cohort of 75 treated acromegalic patients, we studied 13 patients who presented an elevated IGF-I despite post-oGTT nadir GH of ≤1 μg/l. The 12-h daytime GH profile (GH-12 h), nadir GH after oGTT, and basal IGF-I levels were...
Source: Hormone and Metabolic Research - October 2, 2009 Category: Endocrinology Tags: Humans, Clinical Source Type: journals

Acromegaly associated with gangliocytomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11845-009-0433-2Authors R. K. Crowley, Beaumont Hospital Academic Department of Endocrinology Dublin 9 IrelandY. al-Derazi, Beaumont Hospital Department of Neuropathology Dublin 9 IrelandK. Lynch, Beaumont Hospital Department of Neuropathology Dublin 9 IrelandD. Rawluk, Beaumont Hospital Department of Neurosurgery Dublin 9 Irelan...
Source: Irish Journal of Medical Science - September 29, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Diagnosis of Munchausen's Syndrome by an Electronic Health Record SearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 29-year-old man presented to the hospital complaining of seizures, galactorrhea, and acromegaly. He reported a family history of multiple endocrine neoplasia type 2 in both parents, and “genetically proven” multiple endocrine neoplasia type 2 in 2 of 17 siblings. His stated occupation was fraud investigator for a telephone company. He reported a recent hospitalization for the same symptoms at a different medical center, and consented to release of information from other hospitals and family members. Multiple attempts to contact family members were unsuccessful, and there was no record of admissions to other hospitals...
Source: The American Journal of Medicine - September 29, 2009 Category: Journals (General) Authors: Thomas G. Van Dinter, Brian J. Welch Tags: Clinical communications to the editor Source Type: journals

Bronchial carcinoid secreting insulin-like growth factor-1 with acromegalic features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with acromegaly caused by a bronchial carcinoid tumor secreting insulin-like growth factor-1. The patient was treated successfully with bilobectomy. PMID: 19766843 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 24, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Phillips JD, Yeldandi A, Blum M, de Hoyos A Tags: Ann Thorac Surg Source Type: journals

Bronchial Carcinoid Secreting Insulin-Like Growth Factor-1 With Acromegalic Features [CASE REPORTS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with acromegaly caused by a bronchial carcinoid tumor secreting insulin-like growth factor-1. The patient was treated successfully with bilobectomy. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - September 21, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Phillips, J. D., Yeldandi, A., Blum, M., de Hoyos, A. Tags: Lung - cancer CASE REPORTS Source Type: journals

Influence of disease control with pegvisomant on sleep apnoea and tongue volume in patients with active acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In conclusion, successful treatment with pegvisomant can decrease tongue volume, which has benefits for coexisting sleep disordered breathing. PMID: 19773369 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 21, 2009 Category: Endocrinology Authors: Berg C, Wessendorf T, Mortsch F, Forsting M, Teschler H, Weischer T, Mann K, Saller B, Herrmann B Tags: Eur J Endocrinol Source Type: journals

Gamma knife radiosurgery: a safe and effective salvage treatment for pituitary tumors not controlled despite conventional radiotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data indicate that GK is a safe and effective adjunctive treatment for patients with NFPAs and acromegaly not satisfactorily controlled with surgery and radiotherapy. PMID: 19773368 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 21, 2009 Category: Endocrinology Authors: Swords F, Monson J, Besser GM, Chew S, Drake W, Grossman A, Plowman P Tags: Eur J Endocrinol Source Type: journals

[Treatment of pituitary adenomas.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to epidemiological studies, the prevalence of pituitary adenomas is 16.5% and the majority of them are "incidentalomas". The symptoms of pituitary disorders are often non-specific; disturbances of pituitary function, compression symptoms, hypophysis apoplexy or accidental findings may help the diagnosis. The hormonal evaluation of pituitary adenomas is different from the algorithm used in the disorders of peripheral endocrine organs. The first-line therapy of prolactinomas are the dopamine agonists, and the aims of the treatment are to normalize the prolactin level, restore fertility in child-bearing age, dec...
Source: Orvosi Hetilap - September 19, 2009 Category: Journals (General) Authors: Mezosi E, Nemes O Tags: Orv Hetil Source Type: journals

Growth hormone and protein metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Growth hormone (GH) and intracellular STAT 5 signalling represents a very old regulatory system and, whereas insulin dominates periprandially, GH may be viewed as the primary anabolic hormone during stress and fasting. GH exerts metabolic effects both directly and through stimulation of IGF-I, insulin, and free fatty acids (FFA). When well nourished the GH-induced stimulation of IGF-I and insulin is important for tissue anabolism whereas during fasting and other catabolic states GH predominantly stimulates the release and oxidation of FFA which leads to decreased glucose and protein oxidation and preservation of L...
Source: Clinical Nutrition - September 7, 2009 Category: Nutrition Authors: Niels Moller, Mikkel H. Vendelbo, Ulla Kampmann, Britt Christensen, Michael Madsen, Helene Norrelund, Jens O. Jorgensen Tags: Reviews Source Type: journals

A Link between Bone Mineral Density and Serum Adiponectin and Visfatin Levels in Acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Acromegalic patients present hypoadiponectinemia and a favorable bone marker profile. Adiponectin and visfatin could be a link between fat mass and bone in acromegaly. PMID: 19723758 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 31, 2009 Category: Endocrinology Authors: Sucunza N, Barahona MJ, Resmini E, Fernández-Real JM, Ricart W, Farrerons J, Rodríguez Espinosa J, Marin AM, Puig T, Webb SM Tags: J Clin Endocrinol Metab Source Type: journals

High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich alpha-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates the first large scale and high throughput uHPLC/MS/MS-based quantitation of a medium abundance protein (IGF-I) in human serum. Furthermore, the data we have presented for the quantitative analysis of IGF-I suggest that, in this case, monitoring a single SRM transition to a trypsin peptide surrogate is a valid approach to protein quantitation by LC/MS/MS. Copyright (c) 2009 John Wiley & Sons, Ltd. PMID: 19718777 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - August 28, 2009 Category: Chemistry Authors: Kay RG, Barton C, Velloso CP, Brown PR, Bartlett C, Blazevich AJ, Godfrey RJ, Goldspink G, Rees R, Ball GR, Cowan DA, Harridge SD, Roberts J, Teale P, Creaser CS Tags: Rapid Commun Mass Spectrom Source Type: journals

Long-term Experience of Pegvisomant Therapy as a Treatment for AcromegalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pegvisomant was found to be effective, safe, and well-tolerated over the long-term in this analysis of 57 patients acromegaly. Clinical Endocrinology (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - August 28, 2009 Category: Endocrinology Tags: Diabetes & Endocrinology Source Type: info

Clues To Gigantism Provided By Family In Borneo MountainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An indigenous family living in a mountainous area of Malaysian Borneo helped researchers to discover information about genetic mutations associated with acromegaly, a form of gigantism that often results in enlarged hands, feet and facial features. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 24, 2009 Category: Science Source Type: news

Family In Borneo Mountains Provide Clues To GigantismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An indigenous family living in a mountainous area of Malaysian Borneo helped Van Andel Research Institute (VARI) researchers to discover information about genetic mutations associated with acromegaly, a form of gigantism that often results in enlarged hands, feet, and facial features. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 24, 2009 Category: Consumer Health News Tags: Genetics Source Type: news

Clues to gigantism provided by family in Borneo MountainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Van Andel Research Institute) An indigenous family living in a mountainous area of Malaysian Borneo helped Van Andel Research Institute researchers to discover information about genetic mutations associated with acromegaly, a form of gigantism that often results in enlarged hands, feet and facial features. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 21, 2009 Category: Global & Universal Source Type: news

Adrenal morphology and function in acromegalic patients in relation to disease activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our findings confirm that acromegaly affects adrenal size as well as other organs. In addition, we report a stimulatory effect of growth hormone on adrenal function, although the regulation of the hypothalamic–pituitary–adrenal axis is preserved. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9230-yAuthors Alessandro Ciresi, University of Palermo Section of Endocrinology, DOSAC (Dipartimento di Oncologia Sperimentale ed Applicazioni Cliniche) Piazza delle Cliniche 2 90127 Palermo ItalyMarco C. Amato, University of Palermo Section of Endocrinology, DOSAC (Dipartimento d...
Source: Endocrine - August 14, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This kindred exemplifies the aggressive features of pituitary adenomas associated with AIP mutations, while genetic analyses among 3 R271W FIPA families indicate that R271 represents a mutational hotspot that should be studied further in functional studies. PMID: 19684062 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 13, 2009 Category: Endocrinology Authors: Jennings J, Georgitisi M, Holdaway I, Daly A, Tichomirowa M, Beckers A, Aaltonen L, Karhu A, Cameron F Tags: Eur J Endocrinol Source Type: journals

The German ACROSTUDY: Past and Present.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in this large group of pegvisomant-treated patients, long-term data up to five years of treatment are now available. The German data are now merged into the global ACROSTUDY project, a continuing global observational study. PMID: 19684061 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 13, 2009 Category: Endocrinology Authors: Buchfelder M, Schlaffer S, Droste M, Mann K, Saller B, Brübach K, Stalla G, Strasburger C Tags: Eur J Endocrinol Source Type: journals

The value of IGF-1 estimation in adults with GHD.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The GH/IGF-I system, like other endocrine systems, is dynamic and its activity changes with age and sexual maturation, and is influenced by body composition, and other factors. A normal level of IGF-I does not exclude a diagnosis of GHD in adults and the usefulness of IGF-I in the diagnosis of adult GHD has historically been confusing and contentious. The regulation of IGF-I secretion in adults is complex, and is not solely dependent on GH status with factors recognized to influence IGF-I status in patients with GHD including age, gender, exogenous oestrogen therapy, prolactin status, and severity of GHD. The ...
Source: European Journal of Endocrinology - August 13, 2009 Category: Endocrinology Authors: Shalet S, Mukherjee A Tags: Eur J Endocrinol Source Type: journals

Which patients with acromegaly are treated with pegvisomant? an overview of methodology and baseline data in ACROSTUDY.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Analysis of the baseline features of these patients treated with pegvisomant and reported in the ACROSTUDY database underscores the severity of the disease in this subset of patients with acromegaly previously unresponsive to several medical, surgical or radiation treatment approaches. PMID: 19684051 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 13, 2009 Category: Endocrinology Authors: Brue T, Castinetti F, Lundgren F, Koltowska-Haggstrom M, Petrossians P Tags: Eur J Endocrinol Source Type: journals

Elastosonographic evaluation of thyroid nodules in acromegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study has demonstrated a high prevalence of stiff thyroid nodules in acromegaly, greater than that found in non acromegalic goitrous subjects. In acromegalics hard nodules appeared not to be malignant on cytopathological examination, and are probably of fibrous nature. Thus, US-E appears to be of limited value for the diagnosis of thyroid cancer in acromegaly. PMID: 19666699 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 6, 2009 Category: Endocrinology Authors: Scacchi M, Andrioli M, Carzaniga C, Vitale G, Moro M, Poggi L, Pecori Giraldi F, Fatti L, Cavagnini F Tags: Eur J Endocrinol Source Type: journals

Mandibular prognathism caused by acromegaly - a surgical orthodontic caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 22-year-old man presented for orthodontic surgery because of mandibular prognathism. Clinical symptoms suggested acromegaly, and diagnosis was verified by an endocrinologist as well as by radiograph. Bilateral mandibular prognathism often represents the first and most striking physical characteristic of acromegaly; usually, it is also the main reason why patients seek help from orthodontists or maxillo-facial surgeons. This case report recapitulates the clinical and histopathological findings in pituitary growth hormone (GH) adenomas and emphasises their importance in surgical orthodontic planning. Mandibular prognatism,...
Source: Head & Face Medicine - August 5, 2009 Category: ENT & OMF Authors: Martin GosauCorinna VogelAntonios MoralisPeter ProffJohannes KleinheinzOliver Driemel Source Type: journals

Long term effect of external pituitary irradiation on IGF1 levels in patients with acromegaly free of adjunctive treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions At this centre, we have found that a significant number of patients (25/57) achieved persistently normal IGF-1 free of adjunctive treatment for at least 1 year, after external pituitary irradiation for acromegaly. This demonstrates that, with time, external pituitary irradiation achieves a normal IGF-1 in significant numbers of patients with acromegaly, thus obviating the need for life-long expensive medical therapy. For each patient this benefit has to be weighed against the possibility of new hypopituitarism as a result of the treatment. Any decision to use external pituitary irradiation is easier in the cont...
Source: European Journal of Endocrinology - August 5, 2009 Category: Endocrinology Authors: Mullan K, Sanabria C, Abram P, McConnell M, Courtney H, Hunter S, McCance D, Leslie H, Sheridan B, Atkinson B Tags: Eur J Endocrinol Source Type: journals