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International Society for Heart & Lung Transplantation Research FellowshipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
International Society for Heart & Lung Transplantation Research Fellowship ISHLT issues up to three Research Fellowship Awards annually. Each award is in the amount of $40,000. The funding period is for one year. Financial Support The 2010 Awards Program is supported by educational grants from Novartis, Roche, Astellas, XDX and Gilead. Eligibility Requirements 1. The applicant or the applicant's chief of staff/research project director must be a member of the ISHLT in good standing at the time of application and throughout the period of funding. 2. The applicant must be in a clinical or post-doctoral training program...
Source: ScanGrants feed - November 18, 2009 Category: Research Authors: International Society for Heart & Lung Transplantation Source Type: funding

International Society for Heart & Lung Transplantation Nursing and Social Sciences Research GrantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
International Society for Heart & Lung Transplantation Nursing and Social Sciences Research Grant ISHLT issues at least one Nursing and Social Sciences Grant annually in an amount of up to $12,000. The funding period is for one year. Purpose The purpose of this award is to encourage qualified nurses, social scientists and other health care professionals to conduct research related to the areas of end-stage heart and lung disease and transplantation. This award is designated for non-physician health professionals. Eligibility Criteria 1. The PI must be a non-physician member of ISHLT and the Council on Nursing, Health...
Source: ScanGrants feed - November 18, 2009 Category: Research Authors: International Society for Heart & Lung Transplantation Source Type: funding

International Society for Heart & Lung Transplantation 2010 Branislav Radovancevic Memorial Fellowship GrantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
International Society for Heart & Lung Transplantation 2010 Branislav Radovancevic Memorial Fellowship Grant This Award is issued annually in the amount of $75,000. The funding period is for one year. Purpose The purpose of this award is to encourage scholarly clinical work in mechanical circulatory support, particularly in emerging countries, to facilitate scientific exchange regarding MCS, and to provided advanced scholarly clinical training in mechanical circulatory support and total artificial heart therapy. Dr. Radovancevic, a long-time member of ISHLT, was devoted to the encouragement of scientific collaboration...
Source: ScanGrants feed - November 18, 2009 Category: Research Authors: International Society for Heart & Lung Transplantation/Thoratec Source Type: funding

Clinical profile of adrenoleukodysrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract X-linked Adrenoleukodystrophy (ALD) is the most common of the peroxisomal disorder and is associated with functional defect of the very long chain fatty acid (VLCFA) oxidation leading to the accumulation of VLCFA in the white matter and adrenal cortex. Retrospective evaluation of medical records of ALD patients were carried out. In all the 5 patients the duration of the symptoms varied from 1–7 years. Most of them presented with Addisonian crisis (4/5) and hyperpigmentation (5/5), white half of them (3/5) had neurological symptoms. All patients had biochemical evidence of the adrenal insufficiency...
Source: Indian Journal of Pediatrics - November 11, 2009 Category: Pediatrics Tags: Indian Journal of Pediatrics Source Type: journals

Megestrol: Adrenal insufficiency in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Long-Term Safety of Recombinant Human Growth Hormone in Children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: After more than 20 yr, leukemia, a major safety issue initially believed associated with GH, has not been confirmed, but other signals, including risk of second malignancies in patients previously treated with irradiation, have been detected or confirmed through the NCGS. These data further clarify the events associated with rhGH and, although confirming a favorable overall safety profile, they also highlight specific populations at potential risk. PMID: 19906787 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 11, 2009 Category: Endocrinology Authors: Bell J, Parker KL, Swinford RD, Hoffman AR, Maneatis T, Lippe B Tags: J Clin Endocrinol Metab Source Type: journals

Isolated Addison's is unlikely to be caused by mutations in MC2R, MRAP or StAR, three genes responsible for familial glucocorticoid deficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions FGD does not appear be underdiagnosed in the AD population. However, in ~50% of patients with FGD no genetic cause has yet been identified and it is possible that the other, as yet unidentified genes giving rise to FGD maybe implicated in AD. PMID: 19903795 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Dias R, Chan L, Metherell L, Pearce S, Clark A Tags: Eur J Endocrinol Source Type: journals

Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of AAI following maternal exposure to moderate doses of corticosteroids during pregnancy. The neonate, born at term, presented with hypoglycaemia complicated by seizures. The AAI was confirmed by endocrine tests and after exclusion of differential diagnoses. Early diagnosis and treatment led to full recovery. Content Type Journal ArticleCategory Short ReportDOI 10.1007/s00431-009-1095-9Authors Pierre-Jean Saulnier, CHU de Poitiers Department of Clinical Pharmacology and Regional Center of Pharmacovigilance Poitiers FranceXavier Piguel, CHU de Poitiers Department of Endocrinology and Diabetology Poi...
Source: European Journal of Pediatrics - November 9, 2009 Category: Pediatrics Tags: European Journal of Pediatrics Source Type: journals

Identification of a novel mutation in DAX1/NR0B1A gene in two siblings with severe clinical presentation of adrenal hypoplasia congenitaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A novel frameshift mutation of DAX1 gene, which established the molecular etiology of the AHC in the siblings, was identified. Obtaining a precise genetic diagnosis of this adrenal disorder, which, sometimes, cannot be confirmed only by clinical aspects, may have important implications for the long-term management of the disease.OBJETIVO: Pesquisar mutações no gene DAX1/NR0B1A em dois irmãos com suspeita de hipoplasia adrenal congênita (HAC), rara doença potencialmente fatal, para estabelecer sua etiologia molecular. RELATO DOS CASOS: São apresentados os relatos de dois irmãos com síndrome perdedora de ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - November 6, 2009 Category: Endocrinology Source Type: journals

Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion When total cortisol alone is used to interpret SST in patients with liver impairment, 46% may have been classified as having adrenal insufficiency because of low CBG. FCI may be better for the evaluation of HPA axis insufficiency in patients with liver impairment. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Vincent, R. P, Etogo-Asse, F. E, Dew, T., Bernal, W., Alaghband-Zadeh, J., le Roux, C. W Tags: Short Reports Source Type: journals

An unusual case of profound hyponatraemia and bilateral adrenal calcificationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 65-year-old lady who presented with acute confusion and profound hyponatraemia (plasma sodium of 97 mmol/L). Five years earlier she had developed sepsis and was found to have hyponatraemia, thought to be due to syndrome of inappropriate antidiuretic hormone secretion. The patient was lost to follow-up. The patient was covered with steroids and investigations confirmed primary adrenal failure with flat response of cortisol to adrenocorticotropic hormone (ACTH) stimulation and very high level of ACTH. Adrenal auto-antibodies were negative and a computed tomography of the adrenals showed bilateral adrena...
Source: Annals of Clinical Biochemistry - November 4, 2009 Category: Biochemistry Authors: Cassar, C., Procter, R., Davidson, F., Collier, A., Malik, I. A, Ghosh, S., Elhadd, T. A Tags: Case Reports Source Type: journals

T Cell Responses to Steroid Cytochrome P450 21-Hydroxylase in Patients with Autoimmune Primary Adrenal Insufficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with autoimmune Addison's disease have circulating 21OH-specific T cells, with amino acids 342-361 of 21OH possibly constituting a disease-specific epitope presented by HLA-DRB1*0404. PMID: 19890026 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 4, 2009 Category: Endocrinology Authors: Bratland E, Skinningsrud B, Undlien DE, Mozes E, Husebye ES Tags: J Clin Endocrinol Metab Source Type: journals

Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CTLA4 +49 polymorphism is strongly associated with genetic risk for AAD, independentenly from the well known association with HLA class II genes. PMID: 19884265 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 2, 2009 Category: Endocrinology Authors: Brozzetti A, Marzotti S, Tortoioli C, Bini V, Giordano R, Dotta F, Betterle C, De Bellis A, Arnaldi G, Toscano V, Arvat E, Bellastella A, Mantero F, Falorni A Tags: Eur J Endocrinol Source Type: journals

GH replacement in adults: interactions with other pituitary hormone deficiencies and replacement therapies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Severe GH deficiency (GHD) in adults has been described as a clinical entity. However, some of the features associated with GHD could be due to unphysiological and inadequate replacement of other pituitary hormone deficiencies. This may be true for glucocorticoid replacement that lacks a biomarker making dose titration and monitoring difficult. Moreover, oral estrogen replacement therapy decreases IGF1 levels compared with the transdermal route, which attenuates the responsiveness to GH replacement therapy in women. In addition, in untreated female hypogonadism, oral estrogen may augment the features associated with GH...
Source: European Journal of Endocrinology - November 1, 2009 Category: Endocrinology Authors: Filipsson H, Johannsson G Tags: Eur J Endocrinol Source Type: journals

Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the association of serum and synovial fluid cartilage oligomeric matrix protein (COMP) with systemic and local measures of osteoarthritis (OA) activity by bone scintigraphy.Samples of serum and knee joint synovial fluid (275 knees) were obtained from 159 patients with symptomatic OA of at least 1 knee. Bone scintigraphy using 99mTc-labeled methylene diphosphonate was performed, and early-phase knee scans and late-phase whole-body bone scans of 15 additional joint sites were scored semiquantitatively. To control for within-subject correlations of knee data, generalized linear modeling was used in the correlation...
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: Shelby addison, R. Edward Coleman, Sheng Feng, Gary McDaniel, Virginia Byers Kraus Tags: Osteoarthritis Source Type: journals

Words of Wisdom Wednesday: Notable QuotablesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I couldn't resist posting some of my favorite quotes about the dynamic of the father-daughter relationship. What are some of your favorites? I'd love to hear them!"Certain is it that there is no kind of affection so purely angelic as of a father to a daughter. In love to our wives there is desire; to our sons, ambition; but to our daughters there is something which there are no words to express." --Joseph Addison"To a father growing old nothing is dearer than a daughter." --Euripides"He opened the jar of pickles when no one else could. He was the only one in the house who wasn't afraid to into the basemen...
Source: Psychology Today Parenting Center - October 28, 2009 Category: Psychiatry & Psychology Authors: Melissa Blake Tags: Child Development Happiness Parenting Personality Relationships affection ambition daughter desire erma bombeck euripides family father father daughter favorite quotes frying pan garrison keillor hostage joseph addison Source Type: consumer

Corticomedullary mixed tumor of the adrenal gland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 34-year-old woman presented with weight gain, hirsutism, recent hypertension and secondary amenorrhea. Laboratory findings showed hypokalemia, elevated cortisol and androgen levels with normal urine metanephrines and normal aldosteronemia. Abdominal magnetic resonance imaging showed a right heterogeneous adrenal mass measuring 4x6cm with mixed component of fat and adrenal tissue suggesting corticosurrenaloma. After right adrenalectomy, blood pressure normalized and hypokalemia resolved. In the postoperative course, the patient presented adrenal insufficiency treated with hydrocortisone hemisuccinate. Histological exa...
Source: Annales d'Endocrinologie - October 28, 2009 Category: Endocrinology Authors: Trimeche Ajmi S, Chadli Chaieb M, Mokni M, Braham R, Ach K, Maaroufi A, Chaieb L Tags: Ann Endocrinol (Paris) Source Type: journals

Clinical, Immunological, and Genetic Features of Autoimmune Primary Adrenal Insufficiency: Observations from a Norwegian Registry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: AD is almost exclusively autoimmune, with high autoimmune comorbidity. Both anti-21-hydroxylase antibodies and HLA class II can be clinically relevant predictors of AD. HRQoL is reduced, especially among diabetes patients, whereas thyroid disease did not have an impact on HRQoL. Treatment modalities that improve HRQoL are needed. PMID: 19858318 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 26, 2009 Category: Endocrinology Authors: Erichsen MM, Løvås K, Skinningsrud B, Wolff AB, Undlien DE, Svartberg J, Fougner KJ, Berg TJ, Bollerslev J, Mella B, Carlson JA, Erlich H, Husebye ES Tags: J Clin Endocrinol Metab Source Type: journals

Programmed Death Ligand 1 (PD-L1) Gene Variants Contribute to Autoimmune Addison's Disease and Graves' Disease Susceptibility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We confirm the role of PD-L1 variants in GD susceptibility and extend these findings to demonstrate association in two Northern European patient cohorts with AAD. PD-L1 joins the growing number of known susceptibility loci exerting modest effects in these autoimmune disorders. PMID: 19850680 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 22, 2009 Category: Endocrinology Authors: Mitchell AL, Cordell HJ, Soemedi R, Owen K, Skinningsrud B, Wolff AB, Ericksen M, Undlien D, Husebye E, Pearce SH Tags: J Clin Endocrinol Metab Source Type: journals

Pre-Operative Chest X-Ray (CXR) In Breast Cancer Patients - Is It Necessary?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introducation: There is general consensus that routine pre-operative staging in breast cancer patients is unnecessary. In majority of cases, chest X-rays continue to be performed prior to surgery in centres in the UK. If it were demonstrated that this practice was ineffective, units would be able to reduce costs, time and radiation exposure to patients. The aim of this study was to determine detection rates of pulmonary metastases, on routine CXR, in patients undergoing curative surgery for breast cancer. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Sarit Badiani, S. addison, R. Hobson, A. Jewkes Tags: Abstracts Source Type: journals

[Correspondence] Etomidate versus ketamine for sedation in acutely ill patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In their study of sedative drugs for emergency intubation, Patricia Jabre and colleagues conclude that etomidate is associated with an increased incidence of adrenal insufficiency, defined as a random serum cortisol concentration of less than 276 nmol/L or an increase in serum cortisol concentration of less than 250 nmol/L after adrenocorticotropin stimulation. This conclusion might not be warranted, since current clinical testing for adrenocortical function in critically ill patients is unreliable. (Source: LANCET)
Source: LANCET - October 8, 2009 Category: Journals (General) Authors: David Kaufman Tags: Correspondence Source Type: journals

[Correspondence] Etomidate versus ketamine for sedation in acutely ill patients – Authors' replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nicolas Mongardon, Mervyn Singer, and David Kaufman all address questions related to the adrenal insufficiency seen in our trial. We agree with Mongardon and Singer that it is important to note patients who received corticosteroids during follow-up. 73 of 469 patients analysed received corticosteroids after admission to the intensive-care unit. 28-day mortality in the etomidate group did not differ significantly between steroid-treated patients and non-steroid-treated patients (13/42 [31%] vs 68/192 [35%]; p=0·58). These results are in accordance with those reported by Cuthbertson and colleagues in their CORTICUS substudy...
Source: LANCET - October 8, 2009 Category: Journals (General) Authors: P Jabre, D Annane, F Adnet Tags: Correspondence Source Type: journals

Homozygosity of the Polymorphism MICA5.1 Identifies Extreme Risk of Progression to Overt Adrenal Insufficiency among 21-Hydroxylase Antibody-Positive Patients with Type 1 Diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Identifying extreme risk should facilitate monitoring of progression from 21OH antibody positivity to overt AD. The HLA-DR3/0404 genotype defines high-risk subjects for adrenal autoimmunity. MICA5.1/5.1 may define those at highest risk for progression to overt AD, a feature unique to AD and distinct from T1D. PMID: 19820007 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 8, 2009 Category: Endocrinology Authors: Triolo TM, Baschal EE, Armstrong TK, Toews CS, Fain PR, Rewers MJ, Yu L, Miao D, Eisenbarth GS, Gottlieb PA, Barker JM Tags: J Clin Endocrinol Metab Source Type: journals

Oxygen inhibition and incremental layer bond strengths of resin compositesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objectives: When dentists light cure resin composite restorations in increments or after contouring the surface layer to shape with a hand instrument the surface layer is exposed to air during polymerization. The presence of an oxygen inhibited resin surface layer may impact on clinical performance. Conflicting data has been produced in vitro regarding this topic.Methods: To shed further light on this subject the current investigation assessed the thickness of the oxygen inhibited layer (OIL) and subsequent interfacial bond strength at various times post-cure of an “initial increment” for a range of experimen...
Source: Dental Materials - October 5, 2009 Category: Materials Science Authors: Essam S. Shawkat, Adrian C. Shortall, Owen addison, William M. Palin Source Type: journals

Flexion contractures in secondary adrenal insufficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 55-year-old male with flexion contractures of the hips and the knees due to an isolated adrenocorticotropin (ACTH) deficiency, a rare cause of secondary adrenal insufficiency. The presenting symptoms and signs, the laboratory investigations and the treatment are described. The case description is followed by a brief overview of ACTH deficiency and its symptoms and causes. Our case is then compared with other case reports available in the literature. The aetiology of the flexion contractures in adrenal insufficiency is still unclear. The authors want to draw attention to adrenal insufficiency as ...
Source: Clinical Rheumatology - October 1, 2009 Category: Rheumatology Tags: Clinical Rheumatology Source Type: journals

Adrenal insufficiency in acute coronary syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Utilising the LDT, adrenal insufficiency is present in 21.6 percent of patients admitted with ACS. However, this is not associated with any significant morbidity and mortality. PMID: 19907885 [PubMed - in process] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - October 1, 2009 Category: Journals (General) Authors: Norasyikin AW, Norlela S, Rozita M, Masliza M, Shamsul AS, Nor Azmi K Tags: Singapore Med J Source Type: journals

Bilateral ossification of the auricles: an unusual entity and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: True auricular ossification is a quite rare clinical entity with unclear pathogenesis and one should have in mind that there is always the possibility of a serious co-existed disease like endocrinopathy. (Source: Head & Face Medicine)
Source: Head & Face Medicine - September 30, 2009 Category: ENT & OMF Authors: Nicholas MastronikolisPeter ZampakisChristina KalogeropoulouTheodoros StathasVassiliki SiabiEleni GeropoulouPanos Goumas Source Type: journals

Technical details influence the diagnostic accuracy of the 1 mcg ACTH stimulation test.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The high rate of abnormal results, especially in the afternoon, and loss of ACTH through tubing, suggest that morning testing and minimal tubing should be adopted to avoid an inappropriate diagnosis of adrenal insufficiency. Earlier time-points and standardized protocols would facilitate comparison of studies. PMID: 19797501 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 30, 2009 Category: Endocrinology Authors: Wade M, Baid S, Calis K, Raff H, Sinaii N, Nieman L Tags: Eur J Endocrinol Source Type: journals

Prevalence of occult adrenal insufficiency and the prognostic value of a short corticotropin stimulation test in patients with septic shockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:</b> A short corticotropin test using low-dose corticotropin (1 &#956;g) has a good prognostic value. High basal cortisol and a low increase in cortisol on corticotropin stimulation test are predictors of a poor outcome in patients with septic shock. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - September 26, 2009 Category: Intensive Care Authors: Maqbool Muzaffar, Shah Zafar Amin, Wani Fayaz Ahmad, Wahid Abdul, Parveen Shaheena, Nazir Arjumand Source Type: journals

Vendor Notebook - MEDSEEK delivers eHealth ecoSystem to N.C. healthcare companyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MEDSEEK, a Birmingham, Ala.-based provider of healthcare portal and connectivity solutions, has announced that Rex Healthcare, based in Raleigh, N.C., will implement the company’s comprehensive eHealth ecoSystem virtual community. Medicity, Inc., based in Salt Lake City, has announced that IASIS Healthcare has gone live with the Medicity Novo Grid connectivity solution in two (Florida and Utah) of its six healthcare regions, comprising 16 healthcare facilities. (Source: Healthcare IT News)
Source: Healthcare IT News - September 25, 2009 Category: Information Technology Authors: Eric Wicklund Tags: Online Only addison Alabama ANN ARBOR Arizona Arkansas Barrington Birmingham Blue Bell Burlington California Chicago Cielo Clinic emergency department information systems Executive Health Resources Florida Georgia H1N1 Source Type: news

Disorders of PigmentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin color is highly individual and the variations are controlled by numerous genes. The different skin colors result from the size and number of melanosomes and do not mirror the amount of melanocytes. Disorders of pigmentation can result from migration abnormalities of melanocytes from the neural crest to the skin during embryogenesis. In addition, impairment of melanosome transfer to the surrounding keratinocytes, an alteration in melanin synthesis and a defective degradation or removal of melanin may lead to abnormal skin pigmentation. Immunologic or toxic mediated destructions of melanocytes can end in pigmentation di...
Source: JDDG - September 24, 2009 Category: Dermatology Authors: Susanna K. Fistarol, Peter H. Itin Source Type: journals

Hypopituitarism following traumatic brain injury: the prevalence is affected by the use of different dynamic tests and different normal values.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The reported variations in the prevalence rates of hypopituitarism after TBI are in part caused by differences in definitions, endocrine assessments of hypopituitarism and confounding factors. These methodological issues prohibit simple generalizations of results of original studies on TBI-associated hypopituitarism in the perspective of meta-analyses or reviews. PMID: 19783619 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 24, 2009 Category: Endocrinology Authors: Kokshoorn N, Wassenaar M, Biermasz N, Roelfsema F, Smit J, Romijn J, Pereira A Tags: Eur J Endocrinol Source Type: journals

Pulmonary hypertension in a patient with Schmidt syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 26-year-old patient with long-standing autoimmune hypothyroidism. She was doing well until she developed Addisonian crisis accompanied by severe metabolic acidosis, hypoglycemia, hypomagnesemia, and hypokalemia. Subsequently she developed a life-threatening cardiac arrhythmia due to QT prolongation secondary to electrolyte imbalance. The association of autoimmune hypothyroidism and adrenal insufficiency in our patient suggests the diagnosis of autoimmune polyglandular syndrome type II or Schmidt syndrome. An echocardiography that was performed detected pulmonary hypertension without apparent cardiac or lung p...
Source: The American Journal of Emergency Medicine - September 24, 2009 Category: Emergency Medicine Authors: Walid R. Saliba, Wasseem Rock, Mazen Elias Tags: Case Reports Source Type: journals

ULURU Inc. Presents Data on Negative Pressure Related to Altrazeal(TM) at the Diabetic Limb Salvage Conference in Washington, D.C.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ADDISON, Texas, Sept. 24 (HSMN NewsFeed) -- ULURU Inc. (NYSE Alternext: ULU) announced today the presentation of important clinical data and research at the 2009 Diabetic Limb Salvage (DLS) Conference in Washington, D.C. One poster presentation demonstra... Devices, Wound CareULURU, Altrazeal, Nanoflex (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 24, 2009 Category: Pharmaceuticals Source Type: news

Adrenal crisis in treated Addison's disease: a predictable but under-managed event.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The endocrinologist has a responsibility to ensure that Addison's patients have adequate access to life-saving emergency injection materials and repeated, practical training sessions in how to use them, while the GP plays a vital role as in arranging prompt emergency admissions. PMID: 19776201 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 22, 2009 Category: Endocrinology Authors: White K, Arlt W Tags: Eur J Endocrinol Source Type: journals

A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials of DHEA Treatment Effects on Quality of Life in Women with Adrenal Insufficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: DHEA may improve, in a small and perhaps trivial manner, HRQOL and depression in women with adrenal insufficiency. There was no significant effect of DHEA on anxiety and sexual well-being. The evidence appears insufficient to support the routine use of DHEA in women with adrenal insufficiency. PMID: 19773400 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 21, 2009 Category: Endocrinology Authors: Alkatib AA, Cosma M, Elamin MB, Erickson D, Swiglo BA, Erwin PJ, Montori VM Tags: J Clin Endocrinol Metab Source Type: journals

International Society for Magnetic Resonance in Medicine New Entrant Stipend ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Membership Application/Dues Payment Deadline: 3 December 2009New Entrant Stipend Application Deadline: 10 December 2009The ISMRM invites applications for stipends that encourage new entrants to research in areas of interest to the ISMRM. Each awardee will receive US$400 toward the costs of attending the Joint Annual Meeting ISMRM-ESMRMB 2010 in Stockholm, Sweden in May 2010.New This Year: 2009 ISMRM membership is required before application for a New Entrant stipend. If you are not a member, you will need to complete the membership application process on or before 3 December 2009 in order to apply for a New Entrant Stip...
Source: ScanGrants feed - September 17, 2009 Category: Research Authors: International Society for Magnetic Resonance in Medicine Source Type: funding

Factors Contributing to Hospitalization for Gastroparesis ExacerbationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Poor glycemic control, infection, noncompliance with/intolerance of medications, and, perhaps, adrenal insufficiency were contributory factors leading to hospitalizations of gastroparetic patients. Hospitalized patients with gastroparesis exacerbations had elevated ESR and CRP levels. Although many patients with elevated inflammatory markers had evidence of infection, some did not. Assessment of inflammatory markers may help indicate those gastroparetic patients in whom a search for infection should be undertaken. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-...
Source: Digestive Diseases and Sciences - September 17, 2009 Category: Gastroenterology Tags: Digestive Diseases and Sciences Source Type: journals

ULURU Inc. Presents Results of First Randomized Clinical Trial for Altrazeal(TM) at the Symposium on Advanced Wound Care (SAWC) Fall Meeting in Washington D.C.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ADDISON, Texas, Sept. 16 (HSMN NewsFeed) -- ULURU Inc. (NYSE Alternext: ULU) announced today the presentation of results from the first completed randomized clinical trial for Altrazeal at the SAWC Fall symposium in Washington D.C. September 16-18. The r... Devices, Wound CareULURU, Altrazeal (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 16, 2009 Category: Pharmaceuticals Source Type: news

The ACTH-induced cortisol response in acute pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The evidence that severe acute pancreatitis can result in critical illness related corticosteroid insufficiency following impaired adrenal secretion is accumulating. The study by Peng and coworkers in Critical Care certainly contributes to that idea, even though the question whether relative adrenal insufficiency should prompt for treatment by substitution doses of corticosteroids remains unresolved. The study is discussed in terms of the risk factors, circumstances and significance of impaired corticosteroid secretion by adrenals in severe acute pancreatitis. (Source: Critical Care)
Source: Critical Care - September 15, 2009 Category: Intensive Care Authors: Johan Groeneveld Source Type: journals

Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes seven Arab families, in which 18 patients had APS1. In addition to the cardinal features of APS1, some patients exhibited alopecia, diabetes mellitus, nephrocalcinosis and other phenotypes associated with APS1. DNA sequencing of the AIRE gene of patients from this study identified four novel and one recurrent mutation. These mutations likely result in loss of AIRE function in the patients. In addition, it was noted that the non-pathogenic c.834C> G mutation (rs1800520, encoding for p.Ser278Arg) occurs with high incidence in the AIRE gene of Arab individuals. Furthermore, this investigation demonstra...
Source: Clinical Genetics - September 14, 2009 Category: Genetics & Stem Cells Authors: Faiyaz-Ul-Haque M, Bin-Abbas B, Al-Abdullatif A, Abdullah Abalkhail H, Toulimat M, Al-Gazlan S, Almutawa A, Al-Sagheir A, Peltekova I, Al-Dayel F, Zaidi S Tags: Clin Genet Source Type: journals

Activities against hemostatic proteins and adrenal gland ultrastructural changes caused by the brown widow spider Latrodectus geometricus (Araneae: Theridiidae) venom.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brown widow spider (BrWS) (Latrodectus geometricus) venom produces intense systemic reactions such as cramps, harsh muscle nociceptive, nauseas, vomiting and hypertension. The proposed pathogenic mechanisms resulting in these accidents have principally been damages occuring at the nervous system. However, it is suspected that there is also damage of the adrenal glands, as a result of the experimental animal's clinical manifestations, which developed symptoms compatible with acute adrenal insufficiency. We have currently found that the adrenal gland is damaged by this venom gland homogenates (VGH) producing severe alter...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 11, 2009 Category: Biochemistry Authors: Guerrero B, Finol HJ, Reyes-Lugo M, Salazar AM, Sánchez EE, Estrella A, Roschman-González A, Ibarra C, Salvi I, Rodríguez-Acosta A Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: journals

Health notes: CityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aging program Free program for seniors 55 and older consists of social time and health topics. A guest speaker from the Cook County sheriff's office will discuss home safety. 1 p.m. Friday. Our Lady of the Resurrection Medical Center, 5645 W. Addison St.... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - September 8, 2009 Category: American Health Source Type: news

John F. Kennedy's Addison's disease was probably caused by rare autoimmune diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Navy doctor's report sheds new light on the late president's medical records. President Kennedy's Addison's disease, which came to light only after his election in 1960, was most likely caused by a rare autoimmune disease, according to a Navy doctor who reviewed Kennedy's medical records. The disease, autoimmune polyendocrine syndrome type 2, or APS 2, also caused Kennedy's hypothyroidism, according to a report published Tuesday in the Annals of Internal Medicine . (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - September 5, 2009 Category: Science Source Type: news

Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Corticosteroid withdrawal using this protocol had a high success rate and durable effect and was effective in patients with long-standing (up to 45 years) dependency. As symptoms of CWS mimic symptoms of IBD disease flares, gastroenterologists may have difficulty distinguishing them, which may be a contributory factor to the frequency of corticosteroid dependency in IBD patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 3, 2009 Category: Drugs & Pharmacology Authors: S. J. MURPHY, L. WANG, L. A. ANDERSON, A. STEINLAUF, D. H. PRESENT, J. I. MECHANICK Tags: Original articles Source Type: journals

John F. Kennedy had the most complex medical history of any U.S. president, likely had polyendocrine syndrome type IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From the Annals of Internal Medicine:In an Era of Less Media Scrutiny, John F. Kennedy Hid Serious Health Problems from the Public.At the age of 43, he was the youngest man ever elected president. During his campaign and presidency, the media portrayed him as the epitome of youth and vigor. However, a recent review of his medical records reveals that Kennedy had the most complex medical history of any U.S. president.Unbeknownst public, Kennedy was diagnosed with Addison's disease, a rare endocrine disorder in which the adrenal glands do not produce enough of the hormone cortisol.Later, when Kennedy was a senator, he was fo...
Source: Clinical Cases and Images - September 2, 2009 Category: Journals (General) Tags: People Endocrinology Source Type: info

John F. Kennedy's Addison's probably caused by rare autoimmune diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Navy doctor's report sheds new light on the late president's medical records. President Kennedy's Addison's disease, which came to light only after his election in 1960, was most likely caused by a rare autoimmune disease, according to a Navy doctor who reviewed Kennedy's medical records. Autoimmune polyendocrine syndrome type 2, or APS 2, also caused Kennedy's hypothyroidism, according to a report published Tuesday in the Annals of Internal Medicine . (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - September 2, 2009 Category: Science Source Type: news

Current controversies in critical illness-related corticosteroid insufficiency and glucocorticoid supplementation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The stress response, which is triggered by a number of factors, including surgery, results in activation of the hypothalamic pituitary adrenal axis and subsequent release of cortisol from the adrenal glands. Critical illness-related corticosteroid insufficiency is an inadequate corticosteroid response relative to a patient's illness; patients with critical illness-related corticosteroid insufficiency have both insufficient circulating cortisol and impaired cellular use of glucocorticoids. Corticosteroids, such as hydrocortisone, have been cited to improve survival, oxygenation, duration of mechanical ventilation, and i...
Source: Orthopedics - August 31, 2009 Category: Orthopaedics Authors: Gross AK, Winstead PS Tags: Orthopedics Source Type: journals

Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant RecipientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Cytomegalovirus (CMV) is an important pathogen in organ-transplant recipients. There have been frequent reports of CMV-induced adrenal insufficiency in patients with human immunodeficiency virus infection. Herein, we report CMV-induced renal insufficiency in a renal transplant recipient. A 24-year-old woman had gradual onset of weakness, anorexia, nausea, hypotension, and skin hyperpigmentation at 5 months after renal transplantation. The immunosuppression regimen included cyclosporine, mycophenolate mofetil, and corticosteroid (prednisolone, 5 mg/d). Recent history included acute CMV infection, which was treated...
Source: Transplantation Proceedings - August 31, 2009 Category: Transplant Surgery Authors: M. Ardalan, M.M. Shoja Tags: Case Reports Source Type: journals

JFK's Health Problems More Complex Than ThoughtEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
President suffered from a rare autoimmune condition, new report finds Source: HealthDay Related MedlinePlus Topics: Addison's Disease, Thyroid Diseases (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 31, 2009 Category: Consumer Health News Source Type: consumer