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In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interesting activity with IC(50) values of 62.7 and 71.1 mug mL(-1) against C32 and LNCaP, respectively. Two compounds identified in the n-hexane extract, linalool and beta-caryophyllene, were found to be active against C32 cells (IC(50) values of 23.2 and 20.1 mug mL(-1), respectively). Among tested constituents, the highest activity was found...
Source: Natural Product Research - November 20, 2009 Category: Biochemistry Authors: Tundis R, Loizzo MR, Bonesi M, Menichini F, Dodaro D, Passalacqua NG, Statti G, Menichini F Tags: Nat Prod Res Source Type: journals

Definitive molecular cytogenetic characterization of 15 colorectal cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In defining the genetic profiles in cancer, cytogenetically aberrant cell lines derived from primary tumors are important tools for the study of carcinogenesis. Here, we present the results of a comprehensive investigation of 15 established colorectal cancer cell lines using spectral karyotyping (SKY), fluorescence in situ hybridization, and comparative genomic hybridization (CGH). Detailed karyotypic analysis by SKY on five of the lines (P53HCT116, T84, NCI-H508, NCI-H716, and SK-CO-1) is described here for the first time. The five lines with karyotypes in the diploid range and that are characterized by defects in DNA mis...
Source: Genes, Chromosomes and Cancer - November 20, 2009 Category: Cancer & Oncology Authors: Turid Knutsen, Hesed M. Padilla-Nash, Danny Wangsa, Linda Barenboim-Stapleton, Jordi Camps, Nicole McNeil, Michael J. Difilippantonio, Thomas Ried Source Type: journals

Mesothelioma Researchers Find Biological Marker to Help Diagnose Malignant MesotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, strong membranous D2-40 positivity is helpful in differentiation of MM [malignant mesothelioma] from pleural involvement of pulmonary adenocarcinoma, so we suggest that it should be included in the IHC [immunohistochemical] panel used for this purpose.” Additional information about mesothelioma may be found through the Mesothelioma Center. (Source: Asbestos and Mesothelioma News)
Source: Asbestos and Mesothelioma News - November 19, 2009 Category: Environmental Health Authors: jwhitmer Tags: Mesothelioma Mesothelioma Research Malignant Mesothelioma Source Type: news

Comparative Proteomic Analysis of Human Lung Adenocarcinoma Cisplatin-resistant Cell Strain A549/CDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These differentially expressed proteins give some clues to elucidate the mechanism of lung cancer cell resistant of cisplatin, providing the basis of searching for potential target of chemotherapy of lung cancer. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion BAPTA-AM is highly effective in the inhibition of GRP78, down-regulation of GRP78 can significantly increase the sensitivity of adenocacinoma lung cancer to VP-16. All these suggest that inhibition of the expression of GRP78 by chemicals such as BAPTA-AM or anti-sense RNA may be a new therapeutic strategies to lung cancer. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Trichostatin A Induced Bcl-2 Protein Level Decrease Mediated A549/CDDP Cells Apoptosis by Mitochondria PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion TSA induce A549/CDDP cell apoptosis by mitochondria pathway. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Expression and Significance of Nrf2 and Its Target Genes in Pulmonary Adenocarcinoma A549 Cells Resistant to CisplatinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion It proves that the transcription factor Nrf2 and it’s signal pathways are closely related with drug resistance of tumors. Moreover, this provides a new direction to reverse drug resistance and have significance to avoid and overcome drug resistance of tumor. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe an additional case of primary breast ALK1-negative ALCL in the fibrous capsule and cystic fluid of silicone breast implant in a 58 year old woman who underwent breast reconstructive surgery after lumpectomy for her infiltrating breast adenocarcinoma. Morphologically and immunohistochemically, the lymphoma cells may be confused with recurrent infiltrating breast adenocarcinoma or other non-hematolymphoid malignancies. Molecular studies were needed to determine T-lineage differentiation of the malignant lymphoma cells. We will also review the case reports and case series published in the English l...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Li S, Lee AK Tags: Int J Clin Exp Pathol Source Type: journals

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
GATA4 is a transcription factor that plays a role in regulating the normal development of many mesoderm and endoderm derived tissues, including the pancreas. Silencing of GATA4 mRNA expression by promoter methylation has been implicated in carcinogenesis of the ovary, lung and colorectum. By contrast, GATA4 mRNA expression is upregulated in pancreatic cancer cell lines and tissues. To further clarify the relationship of GATA4 to pancreatic cancer, we immunolabeled 90 samples of pancreatic ductal adenocarcinoma using a GATA4 specific monoclonal antibody. Both the intensity and percent of labeling was recorded for each c...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Karafin MS, Cummings CT, Fu B, Iacobuzio-Donahue CA Tags: Int J Clin Exp Pathol Source Type: journals

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Working or exercising after meals and H pylori infection increase the risk of GCA, but higher intakes of rice, fresh vegetables and fruits reduce the risk. PMID: 19916179 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chen MJ, Wu DC, Lin JM, Wu MT, Sung FC Tags: World J Gastroenterol Source Type: journals

Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm (IPMN) in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 mo. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were con...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Sakamoto H, Kitano M, Komaki T, Imai H, Kamata K, Kimura M, Takeyama Y, Kudo M Tags: World J Gastroenterol Source Type: journals

Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras mutated cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oncogenic Ras mutations render the protein constitutively active and promote tumourigenisis via chronic stimulation of effector pathways. In A549 lung adenocarcinoma approximately 50% of the total Ras population is constitutively active yet these cells display only weak activation of the effectors: ERK1/2 and Akt. In order to identify key negative regulators of oncogenic Ras signalling we performed a phosphatome RNAi screen in A549 cells and ranked their effects on phosphorylation of Ser473 of Akt. As expected, the tumour suppressor PTEN emerged as a leading hit – knockdown elevated Akt activation to 70% of maximal ...
Source: BJ Disease - November 19, 2009 Category: Biochemistry Authors: J Omerovic, M J. Clague, I A. Prior Tags: BJ Signal Source Type: journals

Cervical cytology in patients with postmenopausal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the role of cervical cytology in the diagnosis of post or perimenopausal (PM) bleeding was explored. A total of 135 patients with PM bleeding were selected. In all these cases both conventional cervical cytology and histopathology follow up were available. The commonest causes of postmenopausal (PM) bleeding with abnormal histopathology were squamous cell carcinoma of cervix (14), endocervical polyp (13), endometrial adenocarcinomas (13) and simple hyperplasia without atypia (13). There were a total 13 cases of endometrial adenocarcinoma and cervical smears of these cases were reported as high grade squamous...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Jasleen Kaur, Pranab Dey, Subhash Chandra Saha, Arvind Rajwanshi, Raje Nijhawan, Srinivasan Radhika, Nalini Gupta Source Type: journals

α-Mangostin, A Novel Dietary Xanthonew, Suppresses TPA-Mediated MMP-2 and MMP-9 Expressions through the ERK Signaling Pathway in MCF-7 Human Breast Adenocarcinoma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study first investigates the anti-metastatic effect of [alpha]-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7. First, the result demonstrated [alpha]-mangostin could inhibit TPA-induced abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay and Boyden chamber assay. Data also showed [alpha]-mangostin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the downregulation the enzyme activities, protein, ...
Source: Journal of Food Science - November 19, 2009 Category: Food Science Authors: Yuan-Bing Lee, Kung-Chung Ko, Ming-Der Shi, Yi-Chen Liao, Tai-An Chiang, Pei-Fen Wu, You-Xin Shih, Yuan-Wei Shih Source Type: journals

Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment [SPECIAL ARTICLE]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer mortality, despite significant improvements in diagnostic imaging and operative mortality rates. The 5-year survival rate remains less than 5% because of microscopic or gross metastatic disease at time of diagnosis. The Clinical Trials Planning Meeting in pancreatic cancer was convened by the National Cancer Institute's Gastrointestinal Cancer Steering Committee to discuss the integration of basic and clinical knowledge in the design of clinical trials in PDAC. Major emphasis was placed on the enhancement of research to identify and validate the ...
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Philip, Mooney, Jaffe, Eckhardt, Moore, Meropol, Emens, O'Reilly, Korc, Ellis, Benedetti, Rothenberg, Willett, Tempero, Lowy, Abbruzzese, Simeone, Hingorani, Berlin, Tepper Tags: Clinical Trials, Growth Factors, Surgery, Radiation, Chemotherapy, Combined Modality, Translational Oncology, Angiogenesis, Signal Transduction, Gastrointestinal, Cancer Biomarkers SPECIAL ARTICLE Source Type: journals

TB Tied to Increased Lung Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tuberculosis (TB) appears to be linked to an increased risk of lung cancer, particularly adenocarcinoma, according to a meta-analysis appearing in the December 15th International Journal of Cancer. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 18, 2009 Category: Consumer Health News Tags: Hematology-Oncology Source Type: news

Translational advances and novel therapies for pancreatic ductal adenocarcinoma: hope or hype?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesSreenivasa Chandana, Daruka Mahadevan, Expert Reviews in Molecular Medicine, Volume 11 , pp e34AbstractBiological complexity, inaccessible anatomical location, nonspecific symptoms, lack of a screening biomarker, advanced disease at presentation and drug resistance epitomise pancreatic ductal adenocarcinoma (PDA) as a poor-prognosis, lethal disease. Twenty-five years of research (basic, translational and clinical) have barely made strides to improve survival, mainly because of a fundamental lack of knowledge of the biological processes initiating and propagating PDA. However, isolation of pancreas cancer ste...
Source: Expert Reviews in Molecular Medicine - November 18, 2009 Category: Molecular Biology Source Type: journals

Choroidal metastases from lung adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 32-year-old woman presented with an unknown visual deficit. Fundus examination revealed a lesion compatible with a metastatic focus. Diagnostic workup revealed a lung mass and the biopsy was compatible with lung adenocarcinoma. The intraocular lesion was the only metastatic site at the time of diagnosis. She received local choroidal treatment and further systemic therapy. A pneumonectomy was performed. Five months later she progressed systemically and has since then received several lines of chemotherapy. Choroidal metastases are an infrequent site of systemic dissemination and associated with a p...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion An endometrial thickness >8 mm is more likely than that of 8 mm or less to be indicated with endometrial biopsy in premenopausal uterine bleeding. Pipelle endometrial biopsy is an accurate diagnostic procedure for the detection of high-grade endometrial lesions in premenopausal women. Content Type Journal ArticleCategory General GynecologyDOI 10.1007/s00404-009-1290-yAuthors Suna Özdemir, Selçuk University Department of Gynecology and Obstetric, Meram Medical Faculty Konya TurkeyÇetin Çelik, Selçuk University Department of Gynecology and Obstetric, Meram Medical Faculty Ko...
Source: Archives of Gynecology and Obstetrics - November 18, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

The effect of endostatin mediated by human mesenchymal stem cells on ovarian cancer cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We found that MSCs possessed great migratory capacity in vitro and the human ovarian adenocarcinoma cell line SKOV3 could significantly induce the migration of MSCs. Our results provided evidence that MSCs could be utilized as a powerful delivery system of endostatin. The endostatin produced by MSC-EN cells could inhibit the proliferation of SKOV3 cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0728-8Authors Jing Jiang, The Second Affiliated Hospital of Harbin Medical University Department of Obstetrics and Gynecology No. 246, Xue Fu Road, Nan Gang District ...
Source: Journal of Cancer Research and Clinical Oncology - November 17, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Inhibitory Activity of a Phytochemically Characterized Fraction from Streptocaulon juventas on Lung Cancer in Nude MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240600AbstractIn the present study, a 75 % ethanol extract of (SJ), which had a strong inhibitory effect on the proliferation of human lung A549 adenocarcinoma cells, was subjected to bioassay-guided fractionation. The most active fraction (SJF) was obtained using a macroreticular resin column followed by a silica-gel column. Then its effect on lung cancer was investigated in athymic nude mice with A549 tumors while its effects on body weight, blood biochemical indicators, and organ indices were monitored. The results showed that SJF inhibited the tumor growth significantly at day 10 an...
Source: Planta Medica - November 17, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Scientists Release New Data On Endometrial Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current study results from the report, 'A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma,' have been published. According to a study from the United Kingdom, Platinum compounds, taxanes and anthracyclines provide the major effective drug classes in the treatment of advanced and recurrent endometrial cancer and carcinosarcoma. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Salvage high-intensity focused ultrasound for biopsy-confirmed local recurrence of prostate cancer after radical prostatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To present experience in high-intensity focused ultrasound (HIFU) used as a salvage therapy for biopsy-confirmed local recurrence at the vesico-urethral anastomosis after radical prostatectomy (RP). From July 2006, four patients diagnosed with prostate cancer recurrence after RP were treated with HIFU, with or without salvage radiotherapy, using the Sonablate® 500 (Focus Surgery, IN, USA). Biochemical failure was defined as in increase in prostate-specific antigen (PSA) level of >0.2 ng/mL. No patients received any adjuvant therapy after HIFU therapy before reporting failure. The mean age and initial PSA level before RP w...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Akiko Murota-Kawano, Mayura Nakano, Sachiko Hongo, Sunao Shoji, Yoshihiro Nagata, Toyoaki Uchida Source Type: journals

Cross-Sectional Imaging Characteristics of Pituitary Adenomas, Invasive Adenomas and Adenocarcinomas in Dogs: 33 Cases (1988–2006)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pituitary tumors in dogs can be adenomas, invasive adenomas, or adenocarcinomas. In people, invasive adenomas and pituitary adenocarcinomas carry a worse prognosis than adenomas. To identify differentiating features on cross-sectional imaging in dogs with pituitary adenomas, invasive adenomas, and adenocarcinomas. Thirty-three dogs that had computed tomography (CT) or magnetic resonance imaging (MRI) performed and a necropsy diagnosis of pituitary adenoma (n= 20), invasive adenoma (n= 11), or adenocarcinoma (n= 2). Medical records were retrospectively reviewed for signalment, history, and diagnosis. CT and MR images were r...
Source: Journal of Veterinary Internal Medicine - November 17, 2009 Category: Veterinary Research Authors: Rachel E. Pollard, Christopher M. Reilly, Megan R. Uerling, Farica D. Wood, Edward C. Feldman Source Type: journals

Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas. However, more studies are required for a better understanding of these changes. (J Histochem Cytochem 57:1139–1148, 2009) (Source: Journal of Histochemistry and Cytochemistry)
Source: Journal of Histochemistry and Cytochemistry - November 16, 2009 Category: Biochemistry Authors: Gao, C., Wang, A.-Y. Tags: Articles Source Type: journals

Randomized Clinical Trials in Pancreatic AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article critically reviews and ranks 107 prospective, randomized controlled trials (RCT) for pancreatic adenocarcinoma published between 2000 and 2008 identified through a standard MEDLINE literature search strategy, according to a standardized, previously published 3-tiered system (Ia, Ib, and Ic). All trials included in this article are Ia or Ib. Types of treatment reviewed include surgery, chemotherapy, molecular therapy, radiation therapy, immunotherapy, and palliative therapy. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Udo Rudloff, Ajay V. Maker, Murray F. Brennan, Peter J. Allen Source Type: journals

Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PD after CRT was safe and resected patients had interesting survival rates. However, resected patients developed metastatic disease and new neoadjuvant regimens are needed to improve the survival of these patients. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: O. Turrini, F. Viret, L. Moureau-Zabotto, J. Guiramand, V. Moutardier, B. Lelong, M. Giovannini, J.R. Delpero Tags: Original Articles Source Type: journals

Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intentionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Purpose: After total mesorectal excision (TME) for rectal cancer, pathology is standardized with margin status as a predictor for recurrence. This has yet to be implemented after transanal endoscopic microsurgery (TEM) and was investigated prospectively for T1 rectal adenocarcinomas.Patients and methods: Eighty patients after TEM were compared to 75 patients after TME. The study protocol included standardized pathology. TEM patients were eligible when excision margins were negative.Results: TEM was safer than TME as reflected by operating time, blood loss, hospital stay, morbidity, re-operation rate and stoma for...
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: E.J.R. De Graaf, P.G. Doornebosch, R.A.E.M. Tollenaar, E. Meershoek-Klein Kranenbarg, A.C. de Boer, F.C. Bekkering, C.J.H. van de Velde Tags: Original Articles Source Type: journals

Anastomotic leak management after a low anterior resection leading to recurrent abdominal compartment syndrome: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Abdominal compartment syndrome may present as a devastating complication of damage control laparotomy. Prompt recognition and goal-directed management are the cornerstones of treatment. (Source: BioMed Central)
Source: BioMed Central - November 14, 2009 Category: Journals (General) Authors: Kostas ToutouzasEleftheria KleidiPanagiotis DrimousisMargarita BallaMetaxia PapanikolaouAndreas LarentzakisDimitrios TheodorouStylianos Katsaragakis Source Type: journals

Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I read with interest the article by Takubo et al . This collaborative work between Japanese and German workers reported that more than 70% of their cases showed cardiac/fundic-type mucosa adjacent to the tumors studied and proposed it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells. (Source: Human Pathology)
Source: Human Pathology - November 13, 2009 Category: Pathology Authors: Olorunda Rotimi Tags: Correspondence Source Type: journals

Radical resection and outcome for malignant tumors of the pancreatic body and tail.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early diagnosis is crucial for increasing the radical resection rate, and radical resection plays an important role in improving survival for pancreatic body and tail cancer patients. PMID: 19908345 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Han SL, Zhang WJ, Zheng XF, Shen X, Zeng QQ, Ke QH Tags: World J Gastroenterol Source Type: journals

MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present study was to analyse the molecular mechanisms involved in the Interleukin-6 (IL-6) silencing in pancreatic adenocarcinoma cell lines. Our results demonstrate that TNF-, a major IL-6 inducer, is able to induce IL-6 only in three out of six cell lines examined. 5-aza-2'-deoxycytidine (DAC), but not trichostatin A (TSA), activates the expression of IL-6 in all cell lines, indicating that DNA methylation, but not histone deacetylation, plays an essential role in IL-6 silencing. Indeed, the IL-6 upstream region shows a methylation status that correlates with IL-6 expression and binds MeCP2 and H3meK9 only...
Source: Nucleic Acids Research - November 13, 2009 Category: Research Authors: Dandrea, M., Donadelli, M., Costanzo, C., Scarpa, A., Palmieri, M. Tags: Gene Regulation, Chromatin and Epigenetics Source Type: journals

Mucoceles not - Oral cysticercosis and minor salivary gland adenocarcinoma: Two case reports.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present two cases that were clinically diagnosed as mucoceles that were removed because of patient anxiety. However, histological examination revealed dissimilar and medically significant pathologies. Oral cysticercosis and salivary gland adenocarcinoma are rare diseases of the oral mucosa. It is important to consider these and other uncommon diagnoses when evaluating an oral nodule presumed to be a mucocele. We will discuss the natural history and pathogenesis of these disease processes. PMID: 19903436 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - November 13, 2009 Category: Dermatology Authors: Lee KH, Cepeda L, Miller M, Siegel DM Tags: Dermatol Online J Source Type: journals

Research needed to identify relevant targets, molecular pathways of pancreatic ductal adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NCI committee suggested that better phase-3 trials may be key to combating fourth leading cause of U.S. cancer deaths. (Source: HemOncToday.com)
Source: HemOncToday.com - November 13, 2009 Category: Cancer & Oncology Source Type: info

Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term PrognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30% of patients with T1 disease. Pancreaticoduodenectomy should be the preferred approach for most ampullary neoplasms that require surgical resection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1080-7Authors Jordan M. Winter, Johns Hopkins Medical Institutions Department of Surgery Halsted 610, 600 N Wolfe Street Baltimore MD 21287 USAJohn L. Cameron, Johns Hopkins Medical Institutions Department ...
Source: Journal of Gastrointestinal Surgery - November 13, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The RelA/p65 inhibitory effects of SAHA and VPA in vitro and the close relationship of class I HDACs and RelA/p65 in vivo suggest that treatment with HDIs could serve as a promising approach to suppress NF-kappaB activity which in turn may lead to enhanced apoptosis and chemosensitization of pancreatic cancers. (Source: BMC Cancer)
Source: BMC Cancer - November 13, 2009 Category: Cancer & Oncology Authors: Annika LehmannCarsten DenkertJan BudcziesAnn-Christin BuckendahlSilvia Darb-EsfahaniAurelia NoskeBerit MullerMarcus BahraPeter NeuhausManfred DietelGlen KristiansenWilko Weichert Source Type: journals

Epidural anesthesia and cancer recurrence rates after radical prostatectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: No difference was observed between the epidural and control groups in disease-free survival at a median follow-up time of 4.5 years. There is a need for large randomized controlled trials to determine the ability of epidural analgesia to alter disease recurrence rates following radical prostatectomy. PMID: 19911247 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - November 13, 2009 Category: Anesthesiology Authors: Tsui BC, Rashiq S, Schopflocher D, Murtha A, Broemling S, Pillay J, Finucane BT Tags: Can J Anaesth Source Type: journals

Cystic Duct Tubular AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dig Surg 2009;26:369-370 (DOI:10.1159/000236059) (Source: Digestive Surgery)
Source: Digestive Surgery - November 12, 2009 Category: Surgery Source Type: journals

Original article Argon plasma coagulation (APC) for treatment of Barrett’s oesophagusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Argon plasma coagulation offers a safe, minimally invasive method, which gave complete regression of metaplasia and low grade dysplasia usually in more than 70% of patients with Barrett’s oesophagus. Our results show that combination of APC and PPIs is an effective treatment option for most patients with BE. (Source: Articles of Videosurgery and Other Miniinvasive Techniques - TERMEDIA publishing house)
Source: Articles of Videosurgery and Other Miniinvasive Techniques - TERMEDIA publishing house - November 12, 2009 Category: Surgery Source Type: journals

Toll-like Receptors 3 and 7 Agonists Enhance Tumor Cell Lysis by Human {gamma}{delta} T CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined TLR3- and TLR7-expressing pancreatic adenocarcinomas, squamous cell carcinomas of head and neck and lung carcinomas. Poly(I:C) treatment of pancreatic adenocarcinomas followed by coculture with T cells resulted in an upregulation of CD54 on the tumor cells. The interaction of CD54 and the corresponding ligand CD11a/CD18 expressed on T cells is responsible for triggering effector function in T cells. Moreover, treatment with imiquimod downregulated MHC class I molecules on tumor cells possibly resulting in a reduced binding affinity for inhibitory receptor NKG2A expressed on T cells. These results indicate that ...
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Shojaei, H., Oberg, H.-H., Juricke, M., Marischen, L., Kunz, M., Mundhenke, C., Gieseler, F., Kabelitz, D., Wesch, D. Tags: Immunology Source Type: journals

Minimal deviation mucinous adenocarcinoma ('adenoma malignum') of the uterine corpusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary mucinous adenocarcinomas of the uterine corpus are typically low grade and frequently associated with endometrial hyperplasia and/or ordinary endometrioid adenocarcinoma, but may appear as a heterogeneous group of neoplasms. A case is described of a 56-year-old postmenopausal woman who presented with mucinous vaginal discharge. Imaging demonstrated thickened myometrium due to adenomyosis. Serum CA19-9 levels were elevated to 486 U/mL. Microscopic examination of hysterectomy specimens indicated highly differentiated mucinous adenocarcinoma diffusely infiltrating the portion of adenomyosis of the corpus. In some area...
Source: Pathology International - November 12, 2009 Category: Pathology Authors: Kaoru Abiko, Tsukasa Baba, Madoka Ogawa, Yoshiki Mikami, Takashi Koyama, Masaki Mandai, Ikuo Konishi Source Type: journals

Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion That APN expression on stromal cells was observed predominantly in squamous cell carcinoma may account for the efficacy of ubenimex in the postoperative adjuvant setting for squamous cell carcinoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11748-009-0445-xAuthors Shinya Ito, Kyoto University Department of Thoracic Surgery, Graduate School of Medicine Kyoto JapanRyo Miyahara, Kyoto University Department of Thoracic Surgery, Graduate School of Medicine Kyoto JapanRei Takahashi, Kyoto University Department of Pathology and Tumor Biology, Graduate School of Medicine Kyot...
Source: General Thoracic and Cardiovascular Surgery - November 11, 2009 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: journals

Robotic-assisted partial cystectomy with en bloc excision of the urachus and the umbilicus for urachal adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of urachal adenocarcinoma managed with robotic-assisted partial cystectomy. A detailed description of the robotic technique including methods used to resect the tumor, urachus, and umbilicus en bloc is described. A review of the management of urachal adenocarcinoma is presented. The robotic approach is technically feasible and safe, and is an attractive alternative to traditional open or laparoscopic-assisted partial cystectomy for this uncommon genitourinary malignancy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11701-009-0161-7Authors Jose J. Correa, Moffitt Cancer Cente...
Source: Journal of Robotic Surgery - November 11, 2009 Category: Surgery Tags: Journal of Robotic Surgery Source Type: journals

A twisted kiss: in vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, altered nucleotide sequence and repression of transcription are two potential mechanisms of suppression of the anti-metastatic effects of KiSS1 in early breast cancer: Confirmation in larger cohorts and study of functional effects of the 242C>G exon IVa mutation are warranted. Keywords: KiSS1, metastasis-suppressor gene, breast cancer, mutation, transcription. PMID: 19895172 [PubMed - in process] (Source: Neoplasma)
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Pentheroudakis G, Kostadima L, Dova L, Georgiou I, Tzavaras T, Vartholomatos G, Wirtz RM, Fountzilas G, Malamou-Mitsi V, Pavlidis N Tags: Neoplasma Source Type: journals

Short-term Outcomes of Roux-en-Y Stapled Anastomosis after Distal Gastrectomy for Gastric AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion There were no significant disadvantages of employing mechanical stapling for anastomosis, except for the high rate of delayed gastric emptying. More consideration therefore needs to be given to decreasing the frequency of gastric emptying disturbance post surgery using mechanical staples. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1082-5Authors Takeshi Fujita, National Cancer Center Hospital Gastric Surgery Division 5-1-1 Tsukiji, Chuo-ku Tokyo 104-0045 JapanHitoshi Katai, National Cancer Center Hospital Gastric Surgery Division 5-1-1 Tsukiji, Chuo-ku Tokyo ...
Source: Journal of Gastrointestinal Surgery - November 11, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals

Tissue Proteomics Reveals Differential and Compartment-Specific Expression of the Homologs Transgelin and Transgelin-2 in Lung Adenocarcinoma and Its StromaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - November 10, 2009 Category: Biochemistry Tags: article Source Type: journals

Fatal gemcitabine-induced pulmonary toxicity in metastatic gallbladder adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed. CT scan and ultrasound before the surgery did not show any tumor. After the surgery a Pet scan was positive for a hot-spot in the left colon. The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular. The patient was then submitted to three sections of 1,600 mg/m2 of gem...
Source: Cancer Chemotherapy and Pharmacology - November 10, 2009 Category: Cancer & Oncology Tags: Cancer Chemotherapy and Pharmacology Source Type: journals

Detection of Free Peritoneal Cancer Cells in Gastric Cancer Using Cancer-Specific Newcastle Disease VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions NDV-GFP can specifically infect and detect peritoneal gastric cancer cells and offers a more sensitive method compared with conventional cytology. This novel modality may offer enhanced detection of intraperitoneal cancer spread and provide important prognostic information. Content Type Journal ArticleCategory 2009 SSAT Plenary PresentationDOI 10.1007/s11605-009-1071-8Authors Joyce Wong, Memorial Sloan–Kettering Cancer Center Department of Surgery New York NY 10065 USAAllison Schulman, Memorial Sloan–Kettering Cancer Center Department of Surgery New York NY 10065 USAKaitlyn Kelly, Memo...
Source: Journal of Gastrointestinal Surgery - November 10, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals

Gene expression profiling in sinonasal adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Within our microarray study in sinonasal adenocarcinoma we identified two proteins, LGALS4 and CLU, that were significantly differentially expressed in tumors compared to normal tissue. A further evaluation on a new set of tissues, including precancerous stages and low grade tumors, is necessary to evaluate the possibility of using them as diagnostic markers. (Source: BioMed Central)
Source: BioMed Central - November 10, 2009 Category: Journals (General) Authors: Dominique TripodiSylvia QuemenerKarine RenaudinChristophe FerronOlivier MalardIsabelle Guisle-MarsollierVeronique Sebille-RivainChristian VergerChristian GerautCatherine Gratas-Rabbia-Re Source Type: journals