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Survivorship: adult cancer survivors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the next decade, a rapid increase in the number of new cancer diagnoses in the population as well as a growing number of cancer survivors can be expected. Cancer is anticipated to exceed cardiovascular disease as the primary cause of mortality in the United States population. Despite efforts in tobacco control, the aging of the population and obesity epidemic will contribute toward the increasing incidence of cancer. Although oncology specialists will continue to play a critical role in the diagnosis and initial treatment of patients with cancer, primary care providers will need to play an expanding role in the ...
Source: Primary Care - November 17, 2009 Category: Primary Care Authors: Ganz PA Tags: Prim Care Source Type: journals

Discrimination of prolactinoma from hyperprolactinemic non-functioning adenomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, old age, extrasellar tumor extension with relatively low prolactin levels, visual defect, and GH deficiency were considered suggestive of non-functioning pituitary adenoma rather than prolactinoma in hyperprolactinemic pituitary macroadenoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12020-009-9279-7Authors Jae Won Hong, Yonsei University College of Medicine Endocrinology, Department of Internal Medicine, Institute of Endocrinology 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaMi Kyung Lee, Pathology Ilsan Hospital Ilsan KoreaSun Ho Kim, Yonsei University College of Medicine ...
Source: Endocrine - November 13, 2009 Category: Endocrinology Tags: Endocrine Source Type: journals

Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer treatment by comparing cancer survivors to age-matched control women and determined the association between these hormones and postchemotherapy menstrual pattern.Breast cancer patients (n = 127) with American Joint Committee on Cancer stage I to III disease who were premenopausal at diagnosis were enrolled postchemotherapy and observed. The primary endpoint was chemotherapy-related amenorrhea (CRA) ([ge]12 months of amenorrhea after chemotherapy). ...
Source: Cancer - November 13, 2009 Category: Cancer & Oncology Authors: H. Irene Su, Mary D. Sammel, Jamie Green, Luke Velders, Corrie Stankiewicz, Jennifer Matro, Ellen W. Freeman, Clarisa R. Gracia, Angela DeMichele Source Type: journals

Dietary intakes in infertile women, a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study identified differences in body composition but not in dietary habits between HA and PCOS infertile women. We documented, for the first time, a relationship between the accuracy of dietary surveys and the psychological characteristics of subjects with anovulation. This finding suggests that it may be important to be aware of the psychological terrain when planning a dietary survey in infertile women. (Source: Nutrition Journal)
Source: Nutrition Journal - November 10, 2009 Category: Nutrition Authors: Ottavia ColomboGiovanna PinelliMario ComelliPierpaolo MarchettiSabina SieriFurio BrighentiRossella NappiAnna Tagliabue Source Type: journals

The Effects of Opioids and Opioid Analogs on Animal and Human Endocrine Systems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Opioid abuse has increased in the last decade, primarily as a result of increased access to prescription opioids. Physicians are also increasingly administering opioid analgesics for noncancer chronic pain. Thus, knowledge of the long-term consequences of opioid use/abuse has important implications for fully evaluating the clinical usefulness of opioid medications. Many studies have examined the effect of opioids on the endocrine system; however, a systematic review of the endocrine actions of opioids in both humans and animals has, to our knowledge, not been published since 1984. Thus, we reviewed the literature on th...
Source: ENDOCR REV - November 10, 2009 Category: Endocrinology Authors: Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC Tags: Endocr Rev Source Type: journals

Mitoxantrone: benefits and risks in multiple sclerosis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mitoxantrone (MTX) is a synthetic antineoplastic cytotoxic drug, active both on proliferative and non-proliferative cells. The efficacy of MTX has been suggested by many open-label or observational studies and demonstrated in four randomized controlled clinical trials (RCTs). It is indicated for reducing neurological disability and the frequency of clinical relapses in patients with progressive relapsing and worsening relapsing–remitting MS patients. The short-term most frequent adverse events observed in RCTs have been nausea/vomiting, alopecia, an increased risk of urinary and respiratory tract ...
Source: Neurological Sciences - November 3, 2009 Category: Neurology Tags: Neurological Sciences Source Type: journals

Efficacy of Bipolar Radiofrequency Endometrial Ablation vs Thermal Balloon Ablation for Management of Menorrhagia: A Population-Based CohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Study Objective: To compare the efficacy of bipolar radiofrequency ablation (RFA) and thermal balloon ablation (TBA) using treatment failure and postprocedure amenorrhea as outcome measures.Design: Population-based cohort study (Canadian Task Force classification II-2).Setting: Two medical centers in the upper Midwest.Patients: Using the medical records linkage system of the Rochester Epidemiology Project, we identified 455 residents of Olmsted County, Minnesota, who underwent global endometrial ablation because of menorrhagia from January 1, 1998, through December 31, 2005. Amenorrhea was defined as complete ces...
Source: The Journal of Minimally Invasive Gynecology - November 1, 2009 Category: OBGYN Authors: Sherif A. El-Nashar, Matthew R. Hopkins, Douglas J. Creedon, William A. Cliby, Abimbola O. Famuyide Tags: Original Articles Source Type: journals

Office Endometrial Ablation with Local Anesthesia Using the HydroThermAblator System: Comparison of Outcomes in Patients with Submucous Myomas with Those with Normal Cavities in 246 Cases Performed Over 5½ YearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hydrothermablation performed in the medical office using local anesthesia seems to be a safe, effective, and cost-saving procedure for treatment of abnormal uterine bleeding in women with both normal and myomatous uteri. Although the success rate in patients with normal cavities was higher than that achieved in patients with submucous myomas, hysterectomy because of abnormal bleeding related to myomas was avoided in 88.4% of the group with myomas. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - November 1, 2009 Category: OBGYN Authors: Mark H. Glasser, Peter K. Heinlein, Yun-Yi Hung Tags: Original Articles Source Type: journals

Interest of using an underbuttocks drape with collection pouch for early diagnosis of postpartum hemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The underbuttocks collection pouch is a simple, cheap and effective way to make an early objective diagnosis of PPH. It allows medical staff to implement appropriate therapy quickly thus avoiding risks due to delay. The diagnostic threshold to ensure optimal management remains to be determined. Content Type Journal ArticleCategory Materno-fetal MedicineDOI 10.1007/s00404-009-1265-zAuthors Hervé Tixier, Centre Hospitalier Universitaire de Dijon Service de Gynécologie-Obstétrique, Faculté de Médecine 2, bd Maréchal de Lattre de Tassigny BP 77908 21079 Dijon Cedex FranceCarole Boucard, C...
Source: Archives of Gynecology and Obstetrics - October 29, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Corticomedullary mixed tumor of the adrenal gland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 34-year-old woman presented with weight gain, hirsutism, recent hypertension and secondary amenorrhea. Laboratory findings showed hypokalemia, elevated cortisol and androgen levels with normal urine metanephrines and normal aldosteronemia. Abdominal magnetic resonance imaging showed a right heterogeneous adrenal mass measuring 4x6cm with mixed component of fat and adrenal tissue suggesting corticosurrenaloma. After right adrenalectomy, blood pressure normalized and hypokalemia resolved. In the postoperative course, the patient presented adrenal insufficiency treated with hydrocortisone hemisuccinate. Histological exa...
Source: Annales d'Endocrinologie - October 28, 2009 Category: Endocrinology Authors: Trimeche Ajmi S, Chadli Chaieb M, Mokni M, Braham R, Ach K, Maaroufi A, Chaieb L Tags: Ann Endocrinol (Paris) Source Type: journals

Cortisol Linked to Bone Loss in Women With AnorexiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cortisol levels are higher in women with anorexia nervosa and hypothalamic amenorrhea than healthy women, and are strongly associated with depression, anxiety and bone loss, according to a study published online Oct. 16 in the Journal of Clinical Endocrinology & Metabolism. (Source: Modern Medicine)
Source: Modern Medicine - October 26, 2009 Category: Journals (General) Source Type: info

AmenorrheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: AmenorrheaCategory: Diseases and ConditionsCreated: 10/21/2009 2:44:00 PMLast Editorial Review: 10/21/2009 2:44:58 PM (Source: MedicineNet Thyroid General)
Source: MedicineNet Thyroid General - October 21, 2009 Category: Endocrinology Source Type: consumer

AmenorrheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: AmenorrheaCategory: Diseases and ConditionsCreated: 10/21/2009 2:44:00 PMLast Editorial Review: 10/21/2009 2:44:58 PM (Source: MedicineNet Womens Health General)
Source: MedicineNet Womens Health General - October 21, 2009 Category: OBGYN Source Type: consumer

AmenorrheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: AmenorrheaCategory: Diseases and ConditionsCreated: 10/21/2009 2:44:00 PMLast Editorial Review: 10/21/2009 2:44:58 PM (Source: MedicineNet Menopause General)
Source: MedicineNet Menopause General - October 21, 2009 Category: Primary Care Source Type: consumer

Satoyoshi syndrome with unusual skeletal abnormalities and parental consanguinityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 26-year-old Mexican woman, a product of consanguineous parents with clinical characteristics of SS. Our patient, also showed skeletal anomalies not previously reported that seems to be a coincidental finding. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - October 15, 2009 Category: Genetics & Stem Cells Authors: C.A. Venegas-Vega, M.R. Rivera-Vega, S. Cuevas-Covarrubias, J. Orozco, S. Kofman-Alfaro Source Type: journals

Array Comparative Genomic Hybridization Profiling Analysis Reveals Deoxyribonucleic Acid Copy Number Variations Associated with Premature Ovarian Failure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We report the first study of CNV analysis in a large cohort of Caucasian POF patients. In the eight statistically significant CNVs we report, we found five genes involved in reproduction, thus representing potential candidate genes in POF. The current study along with emerging information regarding CNVs, as well as data on their potential association with human diseases, emphasizes the importance of assessing CNVs in cohorts of POF women. PMID: 19837940 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 15, 2009 Category: Endocrinology Authors: Aboura A, Dupas C, Tachdjian G, Portnoï MF, Bourcigaux N, Dewailly D, Frydman R, Fauser B, Ronci-Chaix N, Donadille B, Bouchard P, Christin-Maitre S Tags: J Clin Endocrinol Metab Source Type: journals

Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hypercortisolemia is a potential mediator of bone loss and mood disturbance in these disorders. PMID: 19837921 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 15, 2009 Category: Endocrinology Authors: Lawson EA, Donoho D, Miller KK, Misra M, Meenaghan E, Lydecker J, Wexler T, Herzog DB, Klibanski A Tags: J Clin Endocrinol Metab Source Type: journals

Clinical, Genetic, and Enzymatic Characterization of P450 Oxidoreductase Deficiency in Four Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These patients illustrate the broad clinical spectrum of POR deficiency, including amenorrhea and infertility as the sole manifestation. POR assays based on P450c17 correlate well with hormonal and clinical phenotypes. PMID: 19837910 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 15, 2009 Category: Endocrinology Authors: Sahakitrungruang T, Huang N, Tee MK, Agrawal V, Russell WE, Crock P, Murphy N, Migeon CJ, Miller WL Tags: J Clin Endocrinol Metab Source Type: journals

Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Acute administration of kisspeptin to women with infertility due to HA potently stimulates gonadotropin release, but chronic administration of kisspeptin results in desensitization to its effects on gonadotropin release. These data have important implications for the development of kisspeptin as a novel therapy for reproductive disorders in humans. PMID: 19820030 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 8, 2009 Category: Endocrinology Authors: Jayasena CN, Nijher GM, Chaudhri OB, Murphy KG, Ranger A, Lim A, Patel D, Mehta A, Todd C, Ramachandran R, Salem V, Stamp GW, Donaldson M, Ghatei MA, Bloom SR, Dhillo WS Tags: J Clin Endocrinol Metab Source Type: journals

Sellar neuroblastoma mimicking a pituitary tumour: Case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neuroblastomas of the sellar region are exceedingly rare. Only 2 cases have previously been reported. Management of these tumours depends on the tumour's primary site, the patient's age and histopathological features. We are reporting the case of a 43-year-old woman who developed progressive bitemporal hemianopsia and visual loss, accompanied by amenorrhea and hyponatremia. Laboratory findings revealed a slightly elevated prolactin level. Cranial MR-imaging displayed an intrasellar and suprasellar lesion with a maximum diameter of 2.5cm that was suspicious for a pituitary adenoma or tuberculum sellae meningioma. ...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: K. Schmalisch, T. Psaras, R. Beschorner, J. Honegger Tags: Case reports Source Type: journals

Ovarian ablation by radiation therapy: Is it still an option for the ablation of ovarian function in endocrine responsive premenopausal breast cancer patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Surgical or medical ovarian ablation is likely to be the treatment of choice at the current time, radiation ablation (RA) can be still a reasonable alternative. The efficacy and toxicity of radiation therapy (RT) for ovarian function suppression in 118 premenopausal breast cancer patients were retrospectively evaluated. The median age was 39 years (range 21–52 years). RT was given with either Co-60 or 15MV photons of the linear accelerator. The median total dose was 15Gy in 4 consecutive fractions (range 5Gy single fraction–36Gy in 18 fractions over 3.5 weeks). The endpoint for treatment efficacy was menstrua...
Source: The Breast - October 5, 2009 Category: Cancer & Oncology Authors: Nuran S. Bese, Ayca Iribas, Ahmet Dirican, Didem Oksuz, Gulyuz Atkovar, Ahmet Ober Tags: Original Articles Source Type: journals

Article 18: Women's Health Outcomes After Traumatic Brain InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To examine the long-term impact of traumatic brain injury (TBI) on health outcomes unique to women and other relevant health outcomes. Design: Retrospective cohort study. Setting: 8 acute and rehabilitation facilities in Ontario, Canada. Participants: 105 women with moderate-to-severe TBI (WTBI) 5 to 10 years postinjury, and 105 women without TBI and matched on age, education, and geographic location. Interventions: Questionnaire about women's health issues using face-to-face interview. Demographic and injury-related variables were abstracted from health records of WTBI. Main Outcome Measures: Reproductive funct...
Source: Archives of Physical Medicine and Rehabilitation - September 30, 2009 Category: Rehabilitation Authors: Angela Colantonio, Wanna Mar, Karen Yoshida, Michael Escobar, Nora Cullen, Diana Velikona, Sandro Rizoli, Michael Cusimano, Heather MacLean Tags: Paper Presentations Source Type: journals

Poster 3: Primary Amenorrhea Related to Insiduous Functional Decline from American Spinal Injury Association Grade D to Grade C in an Adolescent with Childhood-Onset Incomplete Spinal Cord InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case demonstrates that while current literature suggests the effects of SCI on the menstrual cycle post-menarche is typically transient, and menstruation should commence as expected in young women who are pre-menarche at time of injury, isolated cases of primary amenorrhea following chronic SCI conflict with current literature and emphasize the need for further research investigating the effects of SCI on menstruation. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 30, 2009 Category: Rehabilitation Authors: Arta Lahiji, Jaishree Capoor Tags: Early Career Development Source Type: journals

Premature Ovarian FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DR. LEVY is an assistant professor in the Division of General Internal Medicine and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University. Premature ovarian failure (POF), also known as primary ovarian insufficiency, is typically defined as amenorrhea with elevated follicle-stimulating hormone levels occurring prior to age 40 years. “Early menopause,” the cessation of ovarian function in the early 40s, probably represents a continuum of ovarian dysfunction lying between formal POF and normal menopause around age 50. (Source: Internal Medicine News)
Source: Internal Medicine News - September 30, 2009 Category: Internal Medicine Authors: HOWARD P. LEVY Tags: Genetics in Your Practice Source Type: journals

Ovarian ablation by radiation therapy: Is it still an option for the ablation of ovarian function in endocrine responsive premenopausal breast cancer patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgical or medical ovarian ablation is likely to be the treatment of choice at the current time, radiation ablation (RA) can be still a reasonable alternative. The efficacy and toxicity of radiation therapy (RT) for ovarian function suppression in 118 premenopausal breast cancer patients were retrospectively evaluated. The median age was 39 years (range 21-52 years). RT was given with either Co-60 or 15MV photons of the linear accelerator. The median total dose was 15Gy in 4 consecutive fractions (range 5Gy single fraction-36Gy in 18 fractions over 3.5 weeks). The endpoint for treatment efficacy was menstrual status. ...
Source: Breast - September 29, 2009 Category: Cancer & Oncology Authors: Bese NS, Iribas A, Dirican A, Oksuz D, Atkovar G, Ober A Tags: Breast Source Type: journals

Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The peculiar clinical case come to our attention highlighted the complexity of POF aetiology and of the translocation event, even if our results seem to exclude any effect on nuclear organisation. POF phenotype could be partially explained by skewed X chromosome inactivation that influences gene expression. (Source: BioMed Central)
Source: BioMed Central - September 26, 2009 Category: Journals (General) Authors: Sara LissoniSimona BaronchelliNicoletta VillaValeria LucchiniEnrico BetriPietro CavalliLeda Dalpra Source Type: journals

Basketball injuries in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Basketball is a popular, worldwide sport played outdoors and indoors year-round. Patterns of injury are related to abrupt changes in the athlete’s direction, jumping, contact between athletes, the hard playing surface and paucity of protective equipment. Intensity of play and training in the quest of scholarships and professional careers is believed to contribute to an increasing occurrence of injury. Radiologists’ appreciation of the breadth of injury and its relation to imaging and clinical findings should enhance the care of these children. Some of the patterns of injury are well known to rad...
Source: Pediatric Radiology - September 24, 2009 Category: Radiology Tags: Pediatric Radiology Source Type: journals

Gonadal dysfunction and infertility in kidney transplant patients receiving sirolimusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our clinical experience with sirolimus-induced gonadal dysfunction and infertility in both male and female kidney transplant patients. Of the 170 kidney transplant patients, nine (5.3%) patients (six males and three females) were receiving sirolimus. Follow-up data for two male patients were not available. The one unmarried female patient developed amenorrhea post-transplantation and had resumption of her menstrual cycles after discontinuation of sirolimus. The remaining six married patients (four males and two females), who all had fathered or conceived children in the pre-transplantation period, developed ...
Source: International Urology and Nephrology - September 23, 2009 Category: Urology & Nephrology Tags: International Urology and Nephrology Source Type: journals

[Postoperative long-term amenorrhea avoids endometriosis recurrences: That is ultimately proven!]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19766041 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)
Source: Gynecologie, Obstetrique & Fertilite - September 15, 2009 Category: OBGYN Authors: Roman H Tags: Gynecol Obstet Fertil Source Type: journals

Opinion Two: A Case For Early GonadectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Androgen insensitivity is the most common cause of the undervirilized male and results from testosterone receptor abnormalities. Phenotypic presentation ranges from complete external feminization (complete androgen insensitivity) to ambiguous genitalia (partial androgen insensitivity) and finally infertile males. The diagnosis of complete androgen insensitivity is generally made as a result of primary amenorrhea, or after finding a testicle at inguinal herniorrhaphy. Earlier diagnosis is becoming increasingly more common with amniocentesis. There is little debate regarding gender of rearing in patients with complete androg...
Source: Journal of Pediatric and Adolescent Gynecology - September 7, 2009 Category: OBGYN Authors: Darcy A. Kiddo Tags: Opinions in Pediatric and Adolescent Gynecology Source Type: journals

Elevated Testosterone and Hypergonadotropism in Active Adolescents of Normal Weight with OligomenorrheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Study Objective: Oligomenorrhea in active adolescent females of normal weight is presumed to be related to hypoestrogenism secondary to physical activity and decreased fat mass. We hypothesized that active adolescents with oligomenorrhea would have lower estrogen levels than normal controls with similar levels of cardiovascular fitness.Design/Participants: Twenty healthy participants between the ages of 16 and 20 years were recruited at least 2 years postmenarche. Adolescents reporting fewer than 9 cycles a year (n = 6) were compared to 14 controls with monthly menstrual cycles. Histories of eating disorder, hirs...
Source: Journal of Pediatric and Adolescent Gynecology - September 4, 2009 Category: OBGYN Authors: K. Singer, A. Rosenthal, J. Kasa-Vubu Tags: Original Studies Source Type: journals

Randomized open comparative trial of dexamethasone-cyclophosphamide pulse and daily oral cyclophosphamide versus cyclophosphamide pulse and daily oral prednisolone in pemphigus vulgarisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:</b> Early remission was achieved in group B but the relapse rates during the treatment phase or after stopping therapy were comparable. Both therapies had comparable side-effect profiles, although Group B showed greater steroid-induced adverse events. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - September 3, 2009 Category: Dermatology Authors: Sethy Pradeep K, Khandpur Sujay, Sharma Vinod K Source Type: journals

Loss of Cytochrome P450 17A1 Protein Expression in a 17α-Hydroxylase/17,20-Lyase-Deficient 46,XY Female Caused by Two Novel Mutations in the CYP17A1 GeneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract 17α-Hydroxylase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia caused by mutations in the CYP17A1 gene. This condition shows considerable clinical and biochemical variation. Molecular characterization of novel mutations in the CYP17A1 gene and detailed study of their structural, enzymatic, and clinical consequences are required to fully understand enzyme behavior. Here, we present the first molecular characterization of two novel mutations in CYP17A1 in a 15-year-old female Mexican mestizo 46,XY female with primary amenorrhea and lack of pubertal development and severe hypertens...
Source: Endocrine Pathology - September 3, 2009 Category: Pathology Tags: Endocrine Pathology Source Type: journals

Female Athlete Triad Grows by OneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women face a unique danger in sports. Lack of food intake can ultimately cause amenorrhea (an interruption of the menstrual cycle). And the lack of food and loss of menstrual... (Source: About.com Eating Disorders)
Source: About.com Eating Disorders - August 30, 2009 Category: Eating Disorders and Weight Management Source Type: consumer

Androgen insensitivity revealed by surgery in elderly identical twinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Two elderly identical twin sisters with inguinal hernias and malignant gonadic tumors were diagnosed during surgery as having complete androgen insensitivity syndrome. Androgen insensitivity syndrome, also referred to as testicular feminization, is an X-chromosome-linked genetic condition in which the tissues of a genotypic male are unresponsive to androgens because of an anomaly of the androgen receptor. This results in feminization of the external genitalia. The internal genital organs including the cranial part of the vagina, cervix, uterus, and fallopian tubes are absent because of testicular in...
Source: Gynecological Surgery - August 24, 2009 Category: OBGYN Tags: Gynecological Surgery Source Type: journals

Pseudocyesis in a rural southeast Nigerian communityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Pseudocyesis is more common among the African population than in developed countries. Gynaecologists in these regions should have a high index of suspicion to diagnose this and assess the mental status of the subject and the precipitating factors. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - August 23, 2009 Category: OBGYN Authors: Umeora Ouj Source Type: journals

Efficacy and safety of ormeloxifene in management of menorrhagia: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To assess the efficacy and safety of ormeloxifene (centchroman) in the medical management of menorrhagia.Methods: Forty-two women with menorrhagia were recruited for the study. Ormeloxifene was given to each patient 60 mg twice a week for 3 months and then once a week for 1 month. Patients were followed up at 2 and 4 months of therapy, then at 3 and 6 months after treatment was stopped. Menstrual blood loss (MBL) was measured objectively by a pictorial blood loss assessment chart (PBAC) score and subjectively by a visual analog scale (VAS).Results: The pretreatment median PBAC score was 388 (range 169[ndash]835)...
Source: Journal of Obstetrics and Gynaecology Research - August 23, 2009 Category: OBGYN Authors: Alka Kriplani, Vidushi Kulshrestha, Nutan Agarwal Source Type: journals

Association between characteristics of current menses and preference for induced amenorrheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A negative experience with menstruation, a high ranking of life stress and ever use of injectable contraception were independently associated with a preference to avoid menses altogether. (Source: Contraception)
Source: Contraception - August 21, 2009 Category: OBGYN Authors: Ellen Hardy, Eliana Maria Hebling, Maria Helena de Sousa, Elsbeth Kneuper, Rachel Snow Tags: Original Research Articles Source Type: journals

An Unusual Case of Recurrent Autoimmune HypophysitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0029-1225646AbstractAutoimmune hypophysitis (AH) is an inflammatory disease that can present either as empty sella or as pituitary mass. A 16-years-old girl was admitted at our Unit for primary amenorrhea. A pituitary MRI performed 2 years before for severe headache demonstrated a large sellar and suprasellar lesion. As a craniopharyngioma was suspected, the consultant neurosurgeon suggested the removal of the lesion. Two months later, a preoperative MRI showed the disappearance of the lesion and a residual empty sella, figure consistent with AH. When the patient came at our obser...
Source: Experimental and Clinical Endocrinology and Diabetes - August 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

ORIGINAL CONTRIBUTION: Exclusive Breastfeeding and the Risk of Postpartum Relapses in Women With Multiple SclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our findings suggest that exclusive breastfeeding and concomitant suppression of menses significantly reduce the risk of postpartum relapses in MS. Our findings call into question the benefit of foregoing breastfeeding to start MS therapies and should be confirmed in a larger study. Published online June 8, 2009 (doi:10.1001/archneurol.2009.132). (Source: Archives of Neurology)
Source: Archives of Neurology - August 9, 2009 Category: Neurology Authors: Langer-Gould, A., Huang, S. M., Gupta, R., Leimpeter, A. D., Greenwood, E., Albers, K. B., Van Den Eeden, S. K., Nelson, L. M. Tags: Neurology, Multiple Sclerosis/ Demyelinating Disease, Women's Health, Pregnancy and Breast Feeding, Immunology, Immunologic Disorders Original Contribution Source Type: journals

ORIGINAL INVESTIGATION: Lactation and Incidence of Premenopausal Breast Cancer: A Longitudinal StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In this large, prospective cohort study of parous premenopausal women, having ever breastfed was inversely associated with incidence of breast cancer among women with a family history of breast cancer. (Source: Archives of Internal Medicine)
Source: Archives of Internal Medicine - August 9, 2009 Category: Internal Medicine Authors: Stuebe, A. M., Willett, W. C., Xue, F., Michels, K. B. Tags: Oncology, Breast Cancer, Women's Health, Pregnancy and Breast Feeding, Women's Health, Other Original Investigation Source Type: journals

Continuous, daily levonorgestrel/ethinyl estradiol vs. 21-day, cyclic levonorgestrel/ethinyl estradiol: efficacy, safety and bleeding in a randomized, open-label trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Continuous LNG 90 mcg/EE 20 mcg was shown to be a safe and effective OC in this direct comparison to a cyclic OC. Suppression of menses and the potential for no bleeding requiring sanitary protection may be provided by this continuous, low-dose OC. (Source: Contraception)
Source: Contraception - August 7, 2009 Category: OBGYN Authors: Alexander Teichmann, Dan Apter, Janusz Emerich, Klaus Greven, Dagmara Klasa-Mazurkiewicz, Giambi B. Melis, Marek Spaczynski, Gary S. Grubb, Ginger D. Constantine, Daniele Spielmann Tags: Original Research Articles Source Type: journals

Exclusive Breastfeeding May Cut Postpartum MS RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with multiple sclerosis who breastfeed exclusively appear to cut their risk of postpartum relapse by fivefold, based on a study of 32 women with MS. In contrast, those who supplement breastfeeding with formula feedings are at the same high risk of relapsing MS symptoms as are those who don't breastfeed at all. It appears that the benefit of exclusive breastfeeding is due to the prolonged amenorrhea it induces, said Dr. Annette Langer-Gould of Stanford (Calif.) University and her associates. (Source: Ob.Gyn. News)
Source: Ob.Gyn. News - July 31, 2009 Category: OBGYN Authors: MARY ANN MOON Tags: Clinical Rounds Source Type: journals

Body composition of elite, eumenorrheic and amenorrheic, adolescent cross-country runners.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the study was to investigate the seasonal relationship of athletic amenorrhea and body composition in elite, adolescent, cross-country runners. The participants consisted of 28 female adolescent cross-country runners (mean age +/- SD = 15.4 +/- 1.5 years); 17 eumenorrheics and 11 amenorrheics. The participants' body composition was measured pre- and postseason using dual-energy X-ray Absorptiometer (DXA). The eumenorrheics' postseason BMD was significantly greater than the amenorrheics' postseason BMD (F(1,54) = 16.22, p < .05, partial eta2 = .231). The eumenorrheics' postseason bodyweight (F(1,54) = ...
Source: Pediatric Exercise Science - July 31, 2009 Category: Pediatrics Authors: Bonis M, Loftin M, Speaker R, Kontos A Tags: Pediatr Exerc Sci Source Type: journals

GnRH analogue for chemotherapy-induced ovarian damage: too early to say?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest the paper by Badawy et al. , reporting the beneficial effect of goserelin for the prevention of chemotherapy induced amenorrhea and ovarian failure in young breast cancer patients undergoing cytotoxic treatment. Even if we acknowledge the study design and the stringent criteria used for the evaluation of ovarian function recovery after chemotherapy, we have some concerns that we would like to share with the authors and the readers. (Source: Fertility and Sterility)
Source: Fertility and Sterility - July 30, 2009 Category: Reproduction Medicine Authors: Fedro Peccatori, Isabelle Demeestere Tags: Letters to the Editor Source Type: journals

Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Postmenopausal women treated with BZA 20 or 40 mg with CE 0.625 or 0.45 mg had high rates of cumulative amenorrhea that were similar to those reported with placebo. This new menopausal therapy may offer a favorable bleeding and tolerability profile. (Source: Fertility and Sterility)
Source: Fertility and Sterility - July 26, 2009 Category: Reproduction Medicine Authors: David F. Archer, Vivian Lewis, Bruce R. Carr, Sophie Olivier, James H. Pickar Tags: Menopause Source Type: journals

Diagnostic evaluation of metastatic placental site trophoblastic tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:: Placental site trophoblastic tumor is an unusual malignancy that may present remotely from antecedent gestational events. The relatively slow growth rate of this tumor may explain the lack of PET findings in our case. PMID: 19622963 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - July 24, 2009 Category: OBGYN Authors: Kelly T, Alvis C, Abedalthagafi M, Barnes W Tags: Obstet Gynecol Source Type: journals

Female Athlete Triad, Plus OneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The female athlete triad is growing, becoming the female athlete tetrad. Cardiovascular disease joins amenorrhea, osteoporosis, and disordered eating among the problems that women can face in combination when their athletic programs are very strenuous. (Source: About.com Eating Disorders)
Source: About.com Eating Disorders - July 22, 2009 Category: Eating Disorders and Weight Management Tags: health Source Type: consumer

Should amenorrhea be a diagnostic criterion for anorexia nervosa?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents and discusses the arguments for maintaining as well as those for removing the criterion.The psychological and biological literatures on the utility of amenorrhea as a distinguishing diagnostic criterion for AN and as an indicator of illness severity are reviewed.The findings suggest that the majority of differences among patients with AN who do and do not meet the amenorrhea criterion appear largely to reflect nutritional status. Overall, the two groups have few psychological differences. There are mixed findings regarding biological differences between those with AN who do and do not menstruate and t...
Source: International Journal of Eating Disorders - July 20, 2009 Category: Eating Disorders and Weight Management Authors: Evelyn Attia, Christina A. Roberto Source Type: journals

Primary ovarian insufficiency due to steroidogenic cell autoimmunity is associated with a preserved pool of functioning follicles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Two thirds of women with recent-onset SCA-POI had normal AMH concentrations. Women with SCA-POI, differently from those with iPOI, present a preserved ovarian follicle pool for several years after diagnosis of ovarian insufficiency. PMID: 19622621 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 20, 2009 Category: Endocrinology Authors: La Marca A, Marzotti S, Brozzetti A, Stabile G, Carducci Artenisio A, Bini V, Giordano R, De Bellis A, Volpe A, Falorni A, Tags: J Clin Endocrinol Metab Source Type: journals