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Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in streptozotocin-induced diabetic mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the effects of two-drug combinations of gabapentin, oxcarbazepine, and amitriptyline on nociception in diabetic mice and aimed to determine the type of interaction between components. The nociceptive responses in normal and diabetic mice were assessed by the tail-flick test. The testing was performed before and three weeks after the diabetes induction with streptozotocin (150mg/kg; i.p.), when the antinociceptive effects of gabapentin, oxcarbazepine, amitriptyline and their two-drug combinations were examined. Gabapentin (10-40mg/kg; p.o.) and oxcarbazepine (20-80mg/kg; p.o.) produced a significant, dose-depend...
Source: European Journal of Pharmacology - November 13, 2009 Category: Drugs & Pharmacology Authors: Tomić MA, Vučković SM, Stepanović-Petrović RM, Micov AM, Ugrešić ND, Prostran MS, Bošković B Tags: Eur J Pharmacol Source Type: journals

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Qualitest Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 4, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 4, 2009 Category: Drugs & Pharmacology Source Type: organizations

Effect of amitriptyline vs. physiotherapy in management of fibromyalgia syndrome: What predicts a clinical benefit?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions : Therapy with amitriptyline or physiotherapy is equally effective in improving outcome in patients of fibromyalgia over a period of six months. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - November 2, 2009 Category: Internal Medicine Source Type: journals

Involuntary Emotional Expression DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
, or IEED, is a condition in which a person experiences uncontrollable episodes of emotional expression. That is, they have episodes of crying, laughter, or anger that are not in line with their present mood. The condition is also known as labile affect, pseudobulbar affect, emotional lability, and pathological laughing and crying. It can have a severe impact on the lives of both patients and caregivers, as symptoms may leave sufferers feeling guilty, awkward, embarrassed and reluctant to take part in social interaction. IEED is seen most often following brain injury or in people with dementia, motor neuron disease, and m...
Source: Psych Central - November 1, 2009 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Antidepressants Caregivers Disorders General Medications Amyotrophic Lateral Amyotrophic Lateral Sclerosis Array Bipolar Bipolar Disorder Brain Injury Deleterious Effect Dementia Depression Anxiety Emotion Source Type: consumer

Spectrophotometric and chromatographic simultaneous estimation of amitriptyline hydrochloride and chlordiazepoxide in tablet dosage formsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patel Sejal, Patel N JIndian Journal of Pharmaceutical Sciences 2009 71(4):472-476A binary mixture of amitriptyline HCl and chlordiazepoxide was determined by three different methods. The first method involved determination of amitriptyline HCl and chlordiazepoxide using the first derivative spectrophotometric technique at 219 and 230 nm over the concentration ranges of 1-20 and 2-24 &#956;g/ml with mean accuracies 100.9&#177;0.87 and 99.2&#177;1.0%, respectively. The second method was reversed-phase high performance liquid chromatography using methanol: acetonitrile: 0.065 M ammoniu...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Patel Sejal, Patel N J Source Type: journals

Delusion of Oral Parasitosis and Thalamic Pain Syndrome [CASE REPORTS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DISCUSSION: The authors speculate that this specific type of delusion can be elicited by the disruption of the somatosensory pathway and that the subsequent cortical sensory deafferentiation and reorganization arising from this disruption may contribute to the development of delusional parasitosis. (Source: Psychosomatics)
Source: Psychosomatics - October 23, 2009 Category: Psychiatry & Psychology Authors: Hanihara, T., Takahashi, T., Washizuka, S., Ogihara, T., Kobayashi, M. Tags: Somatoform Disorders CASE REPORTS Source Type: journals

Idiopathic Trigeminal Neuropathies: A Presentation of 15 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Of the idiopathic trigeminal neuropathies, half were acute and half were chronic. Mild pain presented more frequently in the chronic patients and was relieved with amitriptyline. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - October 20, 2009 Category: ENT & OMF Authors: María Peñarrocha, Elena Mora, José-Vicente Bagán, Berta García, Miguel Peñarrocha Tags: Basic and Patient-Oriented Research Source Type: journals

Amphiphilic drug persuaded collapse of polyvinylpyrrolidone and poly(ethylene glycol) chains: A dynamic light scattering study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Light scattering has proved to be useful in characterizing colloidal systems. We have studied the interaction between an amphiphilic drug, amitriptyline hydrochloride (AMT), and neutral polymers, polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG), using the dynamic light scattering (DLS) technique. AMT was found to interact with PVP more strongly than PEG. A large decrease of the size of aggregates upon increase of AMT concentration indicates a successive collapse of the polymer conformation. The partial negatively charged oxygen atoms, present in the amide group of PVP, were believed to be responsible for the...
Source: Colloids and Surfaces - October 12, 2009 Category: Biotechnology Authors: Ali MS, Ghosh G, Kabir-Ud-Din Tags: Colloids Surf B Biointerfaces Source Type: journals

QT Alterations in Psychopharmacology: Proven Candidates and Suspects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Psychotropics are among the most common causes of drug induced acquired long QT syndrome. Blockage of Human ether-a-go-go-related gene (HERG) potassium channel by psychoactive drugs appears to be related to this adverse effect. Antipsychotics such as haloperidol, thioridazine, sertindole, pimozide, risperidone, ziprasidone, quetiapine, olanzapine and antidepressants such as amitriptyline, imipramine, doxepin, trazadone, fluoxetine depress the delayed rectifier potassium current (IKr) in a dose dependent manner in experimental models. The frequency of QTc prolongation (more than 456ms) in psychiatric patients is estimat...
Source: Current Drug Safety - October 6, 2009 Category: Drugs & Pharmacology Authors: Alvarez PA, Pahissa J Tags: Curr Drug Saf Source Type: journals

In Child Pain Relief, Antidepressant And Placebo Found To Be Equally EffectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When used "off-label," the antidepressant amitriptyline works just as well as placebo in treating pain-predominant gastrointestinal disorders in children, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. To view this article's video abstract, go to the AGA's YouTube Channel at http://www.youtube.com/AmerGastroAssn. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 2, 2009 Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news

Antidepressant And Placebo Are Equally Effective In Child Pain ReliefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When used "off-label," the antidepressant amitriptyline works just as well as placebo in treating pain-predominant gastrointestinal disorders in children. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 1, 2009 Category: Science Source Type: news

Children's Belly Aches Don't Disappear With AntidepressantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elavil worked no better than placebo in study of kids with gastrointestinal disorders (Source: Forbes.com Health News)
Source: Forbes.com Health News - October 1, 2009 Category: Consumer Health News Source Type: news

Children's Belly Aches Don't Disappear with AntidepressantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elavil worked no better than placebo in study of kids with gastrointestinal disorders Source: HealthDay Related MedlinePlus Topics: Antidepressants, Children's Health, Digestive Diseases (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 1, 2009 Category: Consumer Health News Source Type: consumer

Antidepressant or placebo?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When used "off-label," the antidepressant amitriptyline works just as well as placebo in treating pain-predominant gastrointestinal disorders in children, as per a newly released study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. To view this article's video abstract, go to the AGA's YouTube Channel at www.youtube.com/AmerGastroAssn........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - October 1, 2009 Category: Consumer Health News Source Type: info

Antidepressant and placebo are equally effective in child pain reliefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(American Gastroenterological Association) When used "off-label," the antidepressant amitriptyline works just as well as placebo in treating pain-predominant gastrointestinal disorders in children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2009 Category: Global & Universal Source Type: news

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 29, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 29, 2009 Category: Drugs & Pharmacology Source Type: organizations

The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Selective norepinephrine reuptake inhibitors can significantly increase the intensity and duration of morphine antinociceptive activity via both alpha(2)-adrenergic and opioid receptors. This interaction was not observed with the selective serotonin inhibitor, citalopram. PMID: 19762762 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - September 20, 2009 Category: Anesthesiology Authors: Pettersen VL, Zapata-Sudo G, Raimundo JM, Trachez MM, Sudo RT Tags: Anesth Analg Source Type: journals

Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excitatory amino acid transporters (EAATs) appear to participate in the pathogenesis of neuropathic pain. The present study was performed to evaluate the effects of the tricyclic antidepressant amitriptyline on the expressions of EAATs in neuropathic pain rats. Using spared nerve injured (SNI) male Sprague Dawley rats, we found that SNI induced an initial EAATs upregulation on postoperative day 1 within the ipsilateral spinal cord dorsal horn, followed by a downregulation on postoperative days 3 and 5. Intraperitoneal administration of amitriptyline reversed the downregulation of EAATs in SNI rats on postoperative days...
Source: Brain Research Bulletin - September 18, 2009 Category: Neurology Authors: Mao QX, Yang TD Tags: Brain Res Bull Source Type: journals

Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study indicates that tricyclic antidepressants given in the perioperative period may be useful in preventing nerve injury-induced sensory changes that contribute to the development of chronic post-surgical neuropathic pain. (Source: Pain)
Source: Pain - September 14, 2009 Category: Anesthesiology Authors: Andre Arsenault, Jana Sawynok Tags: Research papers Source Type: journals

Prophylactic Drugs and Cytokine and Leptin Levels in Children With MigraineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The study objective was to evaluate levels of the cytokines tumor necrosis factor α, interleukin-1β, and interleukin-6 and of leptin, and then to determine the relationship between these levels and clinical responses in children with migraine after prophylactic therapy with one of four drugs. In all, 77 children who needed prophylactic drugs were treated with cyproheptadine, amitriptyline, propranolol, or flunarizine. Serum levels of the cytokines and leptin were measured before and 4 months after the treatment. Results were compared by drug for headache frequency, severity, and duration, the PedMIDAS score, and levels o...
Source: Pediatric Neurology - September 11, 2009 Category: Neurology Authors: Tugba Hirfanoglu, Ayse Serdaroglu, Ozlem Gulbahar, Ali Cansu Tags: Original Articles Source Type: journals

Acquired neuromyotonia following upper respiratory tract infection: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a 37-year-old male subject who presented with burning sensations in his hands and feet with generalised twitching of his limbs, trunk and face. His symptoms developed 2 weeks after an upper respiratory tract infection. There was associated facial flushing and disturbed night sleep but no memory impairment or generalised sweating. Examination showed generalised myokymia and fasciculations and electromyography revealed widespread continuous semi-rhythmic doublets and triplets of low frequency with interspersed silent periods. Anti voltage gated potassium channel (VGKC) antibodies, antinuclear antibodies, anti-acet...
Source: Cases Journal - September 7, 2009 Category: Journals (General) Source Type: journals

The Power of Placebo in Pediatric Functional Gastrointestinal DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
See “Multicenter, randomized placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders,” by Saps M, Youssef N, Miranda A, et al, on page 1261. (Source: Gastroenterology)
Source: Gastroenterology - August 30, 2009 Category: Gastroenterology Authors: Marc A. Benninga, Emeran A. Mayer Tags: Editorials Source Type: journals

The neuraxial effects of intraspinal amitriptyline at low concentrations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The intraspinal administration of amitriptyline to dogs even in low concentrations is strongly associated with the development of intense meningeal adhesive arachnoiditis and is not safe even at low concentrations for which there was no previous evidence of toxicity. PMID: 19690274 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - August 22, 2009 Category: Anesthesiology Authors: Fukushima FB, Barros GA, Marques ME, Vidal EI, Ganem EM Tags: Anesth Analg Source Type: journals

Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and implications: These data demonstrate that low concentrations of amitriptyline suppress the response of human peripheral C-type axons to nicotine by directly inhibiting nAChRs. Blockade of tetrodotoxin-sensitive, voltage-dependent sodium channels does not contribute to this effect. An inhibitory action of amitriptyline on nAChRs in unmyelinated nociceptive axons may be an important component of amitriptyline's therapeutic effect in the treatment of neuropathic pain. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - August 18, 2009 Category: Drugs & Pharmacology Authors: A Freysoldt, J Fleckenstein, PM Lang, D Irnich, P Grafe, RW Carr Source Type: journals

Effects of amitriptyline, a tricyclic antidepressant, on smooth muscle reactivity in isolated rat tracheaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results suggest that amitriptyline does not influence tracheal smooth muscle reactivity at clinical concentrations (<1 μM), but attenuates the reactivity at supraclinical concentrations (≥1 μM). The attenuated response to ACh brought about by amitriptyline is presumably due, at least in part, to the inhibition of phosphatidylinositol (PI) metabolism. The ability of amitriptyline to inhibit the calyculin Ainduced contraction suggests that amitriptyline also inhibits the Ca2+-calmodulin-myosin light chain pathway independently of the inhibition of PI metabolism. Finally, the difference bet...
Source: Journal of Anesthesia - August 14, 2009 Category: Anesthesiology Tags: Journal of Anesthesia Source Type: journals

Tricyclic AntidepressantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article covers how tricyclic antidepressants work, allergies, pregnancy and breast-feeding, side effects common to the medication family, and interactions with drugs and alcohol. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 13, 2009 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: consumer

New to forum, 3rd day on suboxone...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: jamez70 Posted: Thu Aug 13, 2009 12:22 am Diary, I have had SEVERE SEVERE anxiety in my life. Let me try to describe it. Suddenly, out of nowhere, I have a severe panic attack without any real reason (no phobia). I try to go on.. That night, I have another one. I then become afraid to sleep in my bed, because I associate it with the panic attack. Then about 8 hours later, I have another one. Then I wonder "whats wrong with me? Do I have a tumor? Did I have a stroke?".. Then they keep coming and coming. Eventually, I enter a constant state of se...
Source: Suboxone Forum - August 12, 2009 Category: Addiction Source Type: forums

Amitriptyline for pain control in scleritis may help to avoid excessive steroid use in selected cases: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Amitriptyline may be an effective option for pain control in case with scleritis which might otherwise require unnecessarily large doses of immunosuppression. (Source: Cases Journal)
Source: Cases Journal - August 12, 2009 Category: Journals (General) Source Type: journals

DigestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antidepressant RCTs meaningful?The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial of sequenced anti-depressant therapy recruited a broad population of patients representative of outpatients with depression seeking treatment. By contrast, most randomised controlled trials (RCTs) have more restrictive eligibility criteria. STAR*D investigators have now used their data to assess the impact of this aspect of trial design (Am J Psychiatry 2009;166:599-67).They divided 2855 STAR*D participants into a group meeting standard eligibility criteria based on HAM-D score >19, lack of comorbidity and duration of c...
Source: Progress in Neurology and Psychiatry - August 6, 2009 Category: Neurology Tags: Digests Source Type: journals

Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions As there are few differences between the two treatments in efficacy, pregabalin 150 mg twice daily might be the alternative choice as it is associated with fewer adverse effects in our population. (Source: Diabetic Medicine)
Source: Diabetic Medicine - July 30, 2009 Category: Endocrinology Authors: D. Bansal, A. Bhansali, D. Hota, A. Chakrabarti, P. Dutta Tags: Original Articles Source Type: journals

An Insatiable ItchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 77-year-old Caucasian female with a history of asthma, high cholesterol, degenerative joint disease, and stroke presents for assistance in managing post-zoster scalp itch. The patient had shingles approximately 2 years before the clinic visit with lesions in the left V1 distribution. She had a 7-day course of valacyclovir and the rash resolved within 2 weeks. After the rash resolved, she had about 2 weeks of pain, followed by constant, unrelenting pruritus in the same distribution. She had no current pain, numbness, or vision problems. The pruritus is a 3/10 with occasional exacerbations to 5/10. She gets temporary relie...
Source: The Journal of Pain - July 28, 2009 Category: Materials Science Authors: Gordon J. Wood, Tasuku Akiyama, E. Carstens, Anne Louise Oaklander, Gil Yosipovitch Tags: Case Reviews in Pain Source Type: journals

Magnitude of potentially inappropriate prescribing in Germany among older patients with generalized anxiety disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: GPs in Germany often prescribe medications that have been designated as potentially inappropriate to their elderly patients with GAD--especially those with comorbid depressive disorders. Further research is needed to ascertain whether there are specific subgoups of elderly patients with GAD for whom the benefits of these medications outweigh their risks. (Source: BMC Geriatrics)
Source: BMC Geriatrics - July 26, 2009 Category: Geriatrics Authors: Ariel BergerMarko MychaskiwEllen DukesJohn EdelsbergGerry Oster Source Type: journals

Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings employing several structurally different Asm inhibitors identify Asm as primary target in the lung to reduce ceramide concentrations. Inhaling an Asm inhibitor may be a beneficial treatment for CF, with minimal adverse systemic effects. PMID: 19635928 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - July 26, 2009 Category: Molecular Biology Authors: Becker KA, Riethmüller J, Lüth A, Döring G, Kleuser B, Gulbins E Tags: Am J Respir Cell Mol Biol Source Type: journals

[Off-label use of psychotropic medications in paediatric wards: A prospective study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The high rates of off-label prescription documented here and elsewhere highlight the need for further controlled clinical trials to evaluate the risks and benefits of psychotropic medication in children and adolescents. PMID: 19640689 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - July 26, 2009 Category: Pediatrics Authors: Winterfeld U, Le Heuzey MF, Acquaviva E, Mouren MC, Brion F, Bourdon O Tags: Arch Pediatr Source Type: journals

Amitriptyline/citalopram overdose: Cardiogenic shock in an elderly patient treated with insulin: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - July 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Qualitest Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jul 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - July 24, 2009 Category: Drugs & Pharmacology Source Type: organizations

Antidepressant Directly Stimulates Brain Growth Factor ReceptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The tricyclic antidepressant amitriptyline can directly bind and stimulate the growth factor receptors TrkA and TrkB in the brain. Other antidepressants do not have the same properties. The finding suggests a distinct mechanism by which some antidepressant and pain relief compounds may function. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 24, 2009 Category: Science Source Type: news

HPLC of basic drugs using non-aqueous ionic eluents: evaluation of a 3 mum strong cation-exchange material.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HPLC columns packed with 3 mum particle size HPLC Technology Techsphere SCX (propylsulfonic acid-modified) silica offer considerable advantages over 5 mum SCX packings in the analysis of basic drugs using 100% methanol eluents containing an ionic modifier such as ammonium perchlorate. The basic drugs studied included clozapine and norclozapine, olanzapine, quinine and quinidine, and amitriptyline, nortriptyline, imipramine and desipramine. The 3 mum column was not only more efficient for a given column length compared with 5 mum materials, but also elution times were less, a phenomenon observed in reversed-phase system...
Source: Biomedical Chromatography : BMC - July 23, 2009 Category: Biomedical Science Authors: Morgan PE, Manwaring V, Flanagan RJ Tags: Biomed Chromatogr Source Type: journals

Headache (chronic tension-type)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New option(s) added for: Anticonvulsant drugs New option added, for which we found no systematic review or RCTs. Categorised as Unknown effectiveness. Spinal manipulation (chiropractic and osteopathic treatment) Two systematic reviews and one further RCT added to benefits and harms. One RCT identified by one review found greater reduction in headache severity after treatment with palpatory examination plus osteopathic manipulation versus palpatory examination alone or versus instruction to rest in people with muscle tension-type headache. One RCT identified by...
Source: Clinical Evidence - July 22, 2009 Category: Journals (General) Source Type: journals

Efficacy of venlafaxine compared with tricyclic antidepressants in depressive disorder: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractWith respect to the pharmacological characteristic, venlafaxine is comparable with tricyclic antidepressants (TCAs), and venlafaxine might be comparable in efficacy. We performed a systematic review investigating the relative efficacy and tolerability of venlafaxine compared with TCAs (imipramine, clomipramine, amitriptyline, nortriptyline and desipramine). Relevant double-blind randomised trials were identified from systematic searches of electronic databases. An exact analysis of the estimated odds ratios of response of the TCA relative to venlafaxine showed no overall significance of treatment effect (P = 0.38)....
Source: Journal of Psychopharmacology - July 21, 2009 Category: Psychiatry Authors: van den Broek, W., Mulder, P., van Os, E, Birkenhager, T., Pluijms, E, Bruijn, J. Tags: Review Source Type: journals

Effects of oxotremorine and physostigmine on the inhibitory avoidance impairment produced by amitriptyline in male and female mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously observed that amitriptyline and other antidepressants produce impairing effects on inhibitory avoidance (also called passive avoidance) in mice of both sexes. In the present study we investigated the involvement of the cholinergic system in the inhibitory avoidance impairment produced by acute amitriptyline in male and female CD1 mice. For this purpose, the effects on said task of acute i.p. administration of several doses of amitriptyline, either alone or in combination with the cholinergic agonists oxotremorine and physostigmine, were evaluated. Pre-training administration of 5, 7.5, 10 or 15mg/kg ...
Source: Behavioural Brain Research - July 14, 2009 Category: Neurology Authors: Monleón S, Urquiza A, Vinader-Caerols C, Parra A Tags: Behav Brain Res Source Type: journals

Amitriptyline: Sedation, dry mouth and constipation in pregnancy: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - July 13, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Multicenter, Randomized, Placebo-Controlled Trial of Amitriptyline in Children With Functional Gastrointestinal DisordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Both amitriptyline and placebo were associated with excellent therapeutic response. There was no significant difference between amitriptyline and placebo after 4 weeks of treatment. Patients with mild to moderate intensity of pain responded better to treatment. (Source: Gastroenterology)
Source: Gastroenterology - July 12, 2009 Category: Gastroenterology Authors: Miguel Saps, Nader Youssef, Adrian Miranda, Samuel Nurko, Paul Hyman, Jose Cocjin, Carlo Di Lorenzo Tags: Clinical-Alimentary Tract Source Type: journals

Amitriptyline: Sedation, dry mouth and constipation in pregnancy: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 7 (Source: Reactions Weekly)
Source: Reactions Weekly - July 11, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Amitriptyline overdose: Acute intoxication leading to fatal asphyxia?: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 6 (Source: Reactions Weekly)
Source: Reactions Weekly - July 7, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Pharmacological characterization of standard analgesics on mechanical allodynia in streptozotocin-induced diabetic rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study was designed to investigate the anti-allodynic effects of current analgesic agents, such as pregabalin, amitriptyline, mexiletine, morphine, and diclofenac, in a rat model of streptozotocin (STZ)-induced diabetic neuropathy. Diabetic rats developed a sustained decrease in withdrawal threshold response to the von Frey test within 8 weeks after a single injection of STZ (45 mg/kg, i.v.). The anti-allodynic effects of analgesic agents were examined after a single oral or subcutaneous administration at 3 and 7 weeks after beginning of STZ treatment. Pregabalin (3-30 mg/kg, p.o.), an antiepileptic agent, d...
Source: Neuropharmacology - July 6, 2009 Category: Drugs & Pharmacology Authors: Yamamoto H, Shimoshige Y, Yamaji T, Murai N, Aoki T, Matsuoka N Tags: Neuropharmacology Source Type: journals

Amitriptyline overdose: Acute intoxication leading to fatal asphyxia?: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - July 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic FibrosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell Physiol Biochem 2009;24:65-72 (DOI:10.1159/000227814) (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 2, 2009 Category: Cytology Source Type: journals

Amitriptyline: Myoclonus: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 29, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Antidepressant Directly Stimulates Brain Growth Factor ReceptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown. The results are published online and will appear in the June 26 issue of the journal Chemistry & Biology. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 28, 2009 Category: Consumer Health News Tags: Depression Source Type: news