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This page shows you the latest news and research items in this category.

Detect Alzheimer's Disease Years Before Memory Loss And Cognitive Decline Become Apparent
Scientists at Washington University School of Medicine in St. Louis have helped identify many of the biomarkers for Alzheimer's disease that could potentially predict which patients will develop the disorder later in life. Now, studying spinal fluid samples and health data from 201 research participants at the Charles F. and Joanne Knight Alzheimer's Disease Research Center, the researchers have shown the markers are accurate predictors of Alzheimer's years before symptoms develop... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2013 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

Clue To Explain The Reversible Memory Loss Sometimes Caused By The Use Of Statins
The U.S. Food and Drug Administration and physicians continue to document that some patients experience fuzzy thinking and memory loss while taking statins, a class of global top-selling cholesterol-lowering drugs. A University of Arizona research team has made a novel discovery in brain cells being treated with statin drugs: unusual swellings within neurons, which the team has termed the "beads-on-a-string" effect. The team is not entirely sure why the beads form, said UA neuroscientist Linda L. Restifo, who leads the investigation... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 14, 2013 Category: Consumer Health News Tags: Statins Source Type: news

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 13, 2013 Category: Neurology Authors: Andrea C. Paula‐Lima, Jordano Brito‐Moreira, Sergio T. Ferreira Tags: Review Source Type: research

Henry Molaison: The incredible story of the man with no memory
A disastrous brain operation left Henry Molaison forever stuck in the same moment. But his amnesia proved a gift to science. (Source: Telegraph Health)
Source: Telegraph Health - May 10, 2013 Category: Consumer Health News Tags: HM Henry Molaison Suzanne Corkin Jenni Ogden epilepsy Permanent Present Tense amnesia Source Type: news

Research reveals possible reason for cholesterol-drug side effects
(University of Arizona) University of Arizona researchers have identified a clue to explain the reversible memory loss sometimes caused by the use of statins, one of the most widely prescribed medications. Unusual swellings within neurons, which the team has termed the "beads-on-a-string" effect, may be linked to the cognitive decline some patients experience while taking the cholesterol-lowering drugs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 10, 2013 Category: Global & Universal Source Type: news

Self-Reported Increased Confusion or Memory Loss and Associated Functional Difficulties Among Adults Aged ≥60 Years — 21 States, 2011
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - May 9, 2013 Category: American Health Source Type: news

Rethinking Therapeutic Strategies That Target APOE To Slow Amyloid Plaque Accumulation And Alzheimer's
Scientists' picture of how a gene strongly linked to Alzheimer's disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found. People with harmful forms of the APOE gene have up to 12 times the risk of developing Alzheimer's disease compared with those who have other variations of the gene. Many researchers believe that the memory loss and cognitive problems of Alzheimer's result from the buildup over many years of brain amyloid plaques. The plaques are made mostly of a sticky substance called amyloid beta... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 9, 2013 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

Memory Loss, Confusion Noted by Many Older Adults
(Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 9, 2013 Category: Primary Care Tags: Medical News Source Type: news

Battery for ECT Related Cognitive Deficits (B4ECT-ReCoDe): Development and validation.
CONCLUSIONS: B4ECT-ReCoDe, a brief, sensitive measure of cognitive impairments associated with ECT can be used in routine clinical practice. PMID: 23642983 [PubMed - in process] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - May 7, 2013 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Symptom severity predicts prolonged recovery after sport-related concussion, but age and amnesia do not - Meehan WP, Mannix RC, Stracciolini A, Elbin RJ, Collins MW.
OBJECTIVE: To identify predictors of prolonged symptoms in athletes who sustain concussions. STUDY DESIGN: This was a multicenter prospective cohort study of patients in 2 sport concussion clinics. Possible predictors of prolonged symptoms from concussion ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 7, 2013 Category: Global & Universal Tags: Age: Adolescents Source Type: news

The Cognitive Symptoms of Depression
The cognitive symptoms of depression tend to receive less attention than other symptoms of this difficult illness. Namely, symptoms such as sinking mood, fatigue and loss of interest garner more recognition. Yet cognitive symptoms are quite common. “[They] are actually significantly prominent in depression,” said Deborah Serani, Psy.D, a clinical psychologist and author of the book Living with Depression. And these symptoms are incredibly debilitating. “In my opinion, when cognitive symptoms of depression hit, they are more of a pressing concern than physical symptoms.” Cognitive symptoms can interfere with all are...
Source: Psych Central - May 1, 2013 Category: Psychiatry Authors: Margarita Tartakovsky, M.S. Tags: Aging Antidepressants Depression Disorders General Medications Memory and Perception Psychotherapy Treatment Bipolar Disorder Clinical Associate Professor Clinical Psychologist Cognitive Aspects Cognitive Symptoms Deborah Seran Source Type: news

Long‐term effects of neonatal hippocampal lesions on novelty preference in monkeys
Abstract In a recent longitudinal study to assess the development of incidental recognition memory processes in monkeys, we showed that the effects of neonatal hippocampal lesions did alter incidental recognition memory only when the animals reached the juvenile period (Zeamer et al., 2010). The current follow‐up study tested whether this incidental memory loss was long‐lasting, i.e. present in adulthood, or only transitory, due to functional compensation with further brain maturation. The same animals with neonatal hippocampal lesions and their sham‐operated controls were re‐tested in the visual paired‐compariso...
Source: Hippocampus - May 1, 2013 Category: Neurology Authors: Alyson Zeamer, Jocelyne Bachevalier Tags: Rapid Communication Source Type: research

Theory of mind performance in women with posttraumatic stress disorder related to childhood abuse
ConclusionWomen with PTSD stemming from childhood trauma show changes in ToM abilities particularly those often involved in the interpretation of family interactions. In addition, individuals with PTSD showed slower reaction times during the recognition of complex mental states from emotionally salient facial/eye expressions in comparison with healthy subjects. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - May 1, 2013 Category: Psychiatry Authors: A. Nazarov, P. Frewen, M. Parlar, C. Oremus, G. MacQueen, M. McKinnon, R. Lanius Tags: Original Article Source Type: research

Does fish in Mediterranean diet combat memory loss?
This study assessed all the components together rather than focusing on oily fish alone, as the media suggests – in fact, the word 'fish' does not appear once in the Neurology article. Additionally, the 19% reduction in risk quoted by both The Daily Telegraph and the Daily Mail is incorrectly attributed to "people who adhere to a Mediterranean-style diet". This figure actually only applies to non-diabetic people. The risk reduction for the entire study sample was a more moderate 13% reduction in odds. However, both newspapers covered the main methods of the study well. What kind of research was this? Thi...
Source: NHS News Feed - April 30, 2013 Category: Consumer Health News Tags: Food/diet Neurology Source Type: news

The Structure of Avoidance Following Trauma: Development and Validation of the Posttraumatic Avoidance Scale (PAS)
Avoidance is a key maintenance factor in traumatic reactions but currently no satisfactory measures of it exist. Previous factor analytic studies have demonstrated a distinction between conscious attempts to avoid trauma-related stimuli (e.g., trying not to talk or think about the event) versus nonconscious avoidance processes (e.g., emotional numbing, amnesia). Here we develop and validate a multidimensional measure of trauma-related avoidance across two samples. In Sample 1, 485 emergency service personnel completed a 44-item self-report measure of avoidance in relation to an identified occupational trauma. Principal com...
Source: Traumatology recent issues - April 30, 2013 Category: Psychiatry & Psychology Authors: Andrews, L., Joseph, S., Troop, N., Van Rooyen, T., Dunn, B. D., Dalgleish, T. Tags: Articles Source Type: research

Eat oily fish to prevent memory loss, researchers claim
Eating oily fish while avoiding red meat can help prevent memory loss in later life, a study suggests. (Source: Telegraph Health)
Source: Telegraph Health - April 29, 2013 Category: Consumer Health News Source Type: news

Syncope
is a common problem in older persons and, in nursing homes, appears to increase falls and the need for hospital admissions, although there is no good controlled data to support this viewpoint. It is important to recognize that many older persons with syncope have amnesia for the event, increasing the need to consider syncope in the diagnosis of falls. In this issue of the Journal, Khera et al examined the causes of syncope in 352 persons over the age of 65 years. Over a year follow-up, 11% of these persons died. Cardiac syncope was the most common cause, with a combination of volume depletion and/or orthostatic hypotensi...
Source: Journal of the American Medical Directors Association - April 28, 2013 Category: Health Management Authors: John E. Morley Tags: Editorial Source Type: research

Melatonin protects against amyloid‐β‐induced impairments of hippocampal LTP and spatial learning in rats
We examined whether melatonin could protect Aβ‐induced impairments of hippocampal synaptic plasticity, neuronal cooperative activity and learning and memory. Rats received bilateral intra‐hippocampal injection of Aβ1‐42 or Aβ31‐35 followed by intraperitoneal application of melatonin for ten days, and the effects of chronic melatonin treatment on in vivo hippocampal long‐term potentiation (LTP) and theta rhythm and Morris water maze performance were examined. We showed that intra‐hippocampal injection of Aβ1‐42 or Aβ31‐35 impaired hippocampal LTP in vivo, while chronic melatonin treatment reversed Aβ1�...
Source: Synapse - April 27, 2013 Category: Neurology Authors: Xiao‐Jie Liu, Li Yuan, Dong Yang, Wei‐Na Han, Qing‐Shan Li, Wei Yang, Qing‐song Liu, Jin‐Shun Qi Tags: Research Article Source Type: research

Gone, but not forgotten
(University of California - San Diego) An international team of neuroscientists has described for the first time, in exhaustive detail, the underlying neurobiology of an amnesiac who suffered from profound memory loss after damage to key portions of his brain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 22, 2013 Category: Global & Universal Source Type: news

Memory Loss Reversed In Animal Brain Cells
Neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) have taken a major step in their efforts to help people with memory loss tied to brain disorders such as Alzheimer's disease. Using sea snail nerve cells, the scientists reversed memory loss by determining when the cells were primed for learning. The scientists were able to help the cells compensate for memory loss by retraining them through the use of optimized training schedules. Findings of this proof-of-principle study appear in the The Journal of Neuroscience... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 20, 2013 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

Scientists reverse memory loss in animal brain cells
(University of Texas Health Science Center at Houston) Neuroscientists at the University of Texas Health Science Center at Houston have taken a major step in their efforts to help people with memory loss tied to brain disorders such as Alzheimer's disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 17, 2013 Category: Global & Universal Source Type: news

Mental Exercise May Help Keep Seniors Sharp
Even solving puzzles might stave off decline and memory loss, study hints (Source: WebMD Health)
Source: WebMD Health - April 15, 2013 Category: Consumer Health News Source Type: news

Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation
Conclusion: High clinical suspicion and CSF PCR testing are important for early diagnosis of HHV-6 encephalitis post-HSCT. Abnormalities on brain MRI or CSF testing may be minimal and delayed. Diagnosis and management of HHV-6 encephalitis is challenging, and a larger prospective study is needed for further research. (Source: Neurology)
Source: Neurology - April 15, 2013 Category: Neurology Authors: Bhanushali, M. J., Kranick, S. M., Freeman, A. F., Cuellar-Rodriguez, J. M., Battiwalla, M., Gea-Banacloche, J. C., Hickstein, D. D., Pavletic, S., Fahle, G., Nath, A. Tags: Encephalitis, Viral infections ARTICLE Source Type: research

Was Marina Chapman really brought up by monkeys?
Is Marina Chapman a survivor or a fantasist? We meet the Bradford woman who claims she was raised in the jungle by monkeys – and who still enjoys nothing more than grooming her familyMarina Chapman says she isn't as mobile as she once was. It's not so easy to climb trees these days, let alone swing from them. Well, she is about 60 or 62 years old – maybe older. She's not sure. Chapman is tiny, sinewy, bendy. At times she doesn't look quite human – a bit simian, a bit feline and quite beautiful.Perhaps it's not surprising that Marina Chapman seems different from the rest of us. In her formative years, she says, s...
Source: Guardian Unlimited Science - April 13, 2013 Category: Science Authors: Simon Hattenstone Tags: The Guardian Family Children Parents and parenting Anthropology Features Interviews Relationships Science Source Type: news

Older drinkers are more likely to experience memory loss and unsteadiness than younger people
Scientists at Baylor University in Texas, U.S., have discovered that elderly people who drink heavily are more likely to have falls and to become forgetful than younger drinkers are. (Source: the Mail online | Health)
Source: the Mail online | Health - April 12, 2013 Category: Consumer Health News Source Type: news

Does Poor Sleep Lead to Memory Loss?
I have heard about a study showing that lack of deep sleep in seniors contributes to memory problems. What sort of memory would be affected? Is there any way to prevent this from happening? (Source: Dr. Weil Q and A)
Source: Dr. Weil Q and A - April 11, 2013 Category: Consumer Health Advice Source Type: news

Research examines corporate communications in the 'gilded age' of free speech
(University of Cincinnati) New research finds "historical amnesia" in conflicting Supreme Court rulings regarding corporate power and the First Amendment. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 8, 2013 Category: Global & Universal Source Type: news

Transient global amnesia associated with bilateral restricted diffusion in the lateral hippocampus
A 48-year-old man with no significant cardiovascular risk factors developed 3 h of severe anterograde and mild retrograde amnesia, repeatedly asking ‘Is this my coat?’ on emerging shivering from the (cold) English Channel. No other focal neurological symptoms were seen and by the time he reached the emergency department, he had fully recovered, had a normal neurological examination and did not recall the event. He had a past history of gout and reported symptoms consistent with mild Raynaud's syndrome, but had no other significant medical history. Diffusion-weighted brain imaging performed 48 h later ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 8, 2013 Category: Neurosurgery Authors: Webb, A. J. S., Rothwell, P. M. Tags: Genetics, Dementia, Neuroimaging, Hypertension, Memory disorders (psychiatry), Radiology, Musculoskeletal syndromes, Radiology (diagnostics) Neurological pictures Source Type: research

Research Reveals Possible Reason for Cholesterol-Drug Side Effects
UA researchers have identified a clue to explain the reversible memory loss sometimes caused by the use of statins, one of the most widely prescribed medications. Unusual swellings within neurons, which the team has termed the "beads-on-a-string" effect, may be linked to the cognitive decline some patients experience while taking the cholesterol-lowering drugs. (Source: The University of Arizona: Health)
Source: The University of Arizona: Health - April 8, 2013 Category: Universities & Medical Training Authors: La Monica Everett-Haynes Source Type: research

What Causes Forgetfulness?
Ever forget something? Nope, me either. Unless I'm forgetting that I forgot where I hid the early birthday present I bought, where I parked my car at the mall or the name of the new neighbor I met last week. Nah, not me. But, if I were to forget something, it turns out there's many causes for that phenomenon. Some, like stress and distraction, are things that we can manage or reduce, and thus improve our memory's functioning. Others, like Alzheimer's and other diseases, are more difficult to curb. It's important to recognize the symptoms of Alzheimer's disease, receive an early diagnosis and begin treatment accordingly...
Source: About Alzheimers Disease - April 7, 2013 Category: Consumer Health Advice Source Type: news

Experimental sleep drug may cause fewer side effects: Merck study
CHICAGO (Reuters) - A study in rats and monkeys suggests an experimental Merck & Co sleep drug may help induce sleep without causing the memory loss and attention problems sometimes seen in the commonly used drugs Ambien and Lunesta, company researchers said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - April 3, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Common Fruit Fly Key To Discovering How Memories Are Written Into Brain Cells
Scientists have identified a key molecule responsible for triggering the chemical processes in our brain linked to our formation of memories. The findings, published in the journal Frontiers in Neural Circuits, reveal a new target for therapeutic interventions to reverse the devastating effects of memory loss. The BBSRC-funded research, led by scientists at the University of Bristol, aimed to better understand the mechanisms that enable us to form memories by studying the molecular changes in the hippocampus - the part of the brain involved in learning... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 2, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Clinical Experience of Modified Diffusion‐Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia: An 8‐Year Large‐Scale Clinical Study
CONCLUSIONSA modified TGA DWI protocols for detecting TGA lesions are useful in large‐scale clinical practice for confirming the diagnosis of TGA patients with clinical findings. (Source: Journal of Neuroimaging)
Source: Journal of Neuroimaging - April 2, 2013 Category: Radiology Authors: Jungeun Kim, Yooseok Kwon, Youngsoon Yang, Il Mi Jang, YoungHee Chang, Young Ho Park, Jae Won Jang, Jae Hyoung Kim, SangYun Kim Tags: Clinical Investigative Study Source Type: research

Tests to Predict Heart Problems and Stroke May Be More Useful Predictor of Memory Loss than Dementia Tests
MINNEAPOLIS – Risk prediction tools that estimate future risk of heart disease and stroke may be more useful predictors of future decline in cognitive abilities, or memory and thinking, than a dementia risk test, according to a new study published in the April 2, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology. (Source: American Academy of Neurology)
Source: American Academy of Neurology - April 1, 2013 Category: Medical Law Source Type: news

Tests to predict heart problems may be more useful predictor of memory loss than dementia tests
(American Academy of Neurology) Risk prediction tools that estimate future risk of heart disease and stroke may be more useful predictors of future decline in cognitive abilities, or memory and thinking, than a dementia risk score, according to a new study published in the April 2, 2013, print issue of Neurology®, the medical journal of the American Academy of Neurology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 1, 2013 Category: Global & Universal Source Type: news

Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF
A 35-year-old man developed progressive memory problems and personality changes over the course of 6 months. This amnesia culminated in overt functional impairment as he began getting lost in familiar places and paid his rent multiple times in one day. He then displayed increased aggression and was admitted to hospital after assaulting a family member. (Source: Neurology)
Source: Neurology - April 1, 2013 Category: Neurology Authors: Mat, A., Adler, H., Merwick, A., Chadwick, G., Gullo, G., Dalmau, J. O., Tubridy, N. Tags: All Neuropsychology/Behavior, All Oncology, Paraneoplastic syndrome CLINICAL/SCIENTIFIC NOTES Source Type: research

Cognitive Impairment: Pearls for Practice
Some degree of memory problems, as well as a modest decline in other thinking skills, is a fairly common part of aging. There's a difference, however, between normal changes in memory, mild cognitive impairment (MCI), and the type of memory loss associated with Alzheimer disease (AD) and related dementias. As people age, they may experience some occasional memory gaps, such as not remembering someone's name that they haven't seen recently or where they put their keys. What's not normal and suggests an MCI diagnosis are additional concerns in the areas of language, judgment, and problem-solving or more frequent memory loss,...
Source: The Journal for Nurse Practitioners - April 1, 2013 Category: Nursing Authors: Laurel Halloran Tags: Hot Topics in Primary Care Source Type: research

Predicting health‐related quality of life 2 years after moderate‐to‐severe traumatic brain injury
ConclusionsFuture interventions should focus on aspects related to HRQL that are more easily modified, such as physical functioning, home and social integration, productivity, and mental and emotional status. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - April 1, 2013 Category: Neurology Authors: M. V. Forslund, C. Roe, S. Sigurdardottir, N. Andelic Tags: Original Article Source Type: research

A Surprising Early Sign of Lewy Body Dementia
What's a sign that you may be more likely to develop Lewy body dementia? Some might think that a symptom like memory loss or poor judgment would be on that list. Actually, according to researchers at the American Academy of Neurology annual meeting, acting out your dreams may be a key early symptom of Lewy body dementia. Researchers presented a study at about REM sleep behavior disorder where people not only vividly dream but actually physically act out their dreams by moving their bodies, getting up, shouting, hitting and more. They found a significantly high correlation, especially for men, of acting out dreams and deve...
Source: About Alzheimers Disease - March 29, 2013 Category: Consumer Health Advice Source Type: news

Scientists identify brain's 'molecular memory switch'
(University of Bristol) Common fruit fly key to discovery as to how memories are written into brain cells.Scientists have identified a key molecule responsible for triggering the chemical processes in our brain linked to our formation of memories. The findings, published in the journal Frontiers in Neural Circuits, reveal a new target for therapeutic interventions to reverse the devastating effects of memory loss. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 28, 2013 Category: Global & Universal Source Type: news

Herpes viruses may lead to memory loss, cognitive declines
Researcher said strongest effect was seen in individuals who don't exercise (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - March 26, 2013 Category: Consumer Health News Source Type: news

Researchers find a way to predict the date of a woman's final menstrual period
A new UCLA-led study suggests a way to predict when a woman will have her final menstrual period. The findings, published in the April issue of the peer-reviewed Journal of Clinical Endocrinology and Metabolism, could help women and physicians gauge the onset of menopause-related bone loss, which generally begins a year prior to the last period.The researchers used women's ages, menstrual bleeding patterns and measurements of hormone levels to estimate the amount of time until they were likely to reach menopause, said the study's lead author, Dr. Gail Greendale, professor of medicine in the division of geriatrics at the Da...
Source: UCLA Newsroom: Health Sciences - March 26, 2013 Category: Universities & Medical Training Source Type: news

Kessler Foundation scientist receives National MS Society grant for new memory study
(Kessler Foundation) Nancy Chiaravalloti, Ph.D., was awarded a $43,494 grant to study the efficacy of a new cognitive treatment for memory loss in MS. Dr. Chiaravalloti, PhD, director of Neuropsychology and Neuroscience Research at Kessler Foundation, is an expert in cognitive rehabilitation research in traumatic brain injury and MS. This one-year pilot project, titled, "Stylistic Memory Enhancement," is aimed at improving learning and remembering of information that patients need on a daily basis. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 25, 2013 Category: Global & Universal Source Type: news

Egocentric virtual maze learning in adult survivors of childhood abuse with dissociative disorders: Evidence from functional magnetic resonance imaging
Abstract: Present neuroimaging findings suggest two subtypes of trauma response, one characterized predominantly by hyperarousal and intrusions, and the other primarily by dissociative symptoms. The neural underpinnings of these two subtypes need to be better defined. Fourteen women with childhood abuse and the current diagnosis of dissociative amnesia or dissociative identity disorder but without posttraumatic stress disorder (PTSD) and 14 matched healthy comparison subjects underwent functional magnetic resonance imaging (fMRI) while finding their way in a virtual maze. The virtual maze presented a first-person view (ego...
Source: Psychiatry Research: Neuroimaging - March 25, 2013 Category: Psychiatry Authors: Godehard Weniger, Jakob Siemerkus, Antonia Barke, Claudia Lange, Mirjana Ruhleder, Ulrich Sachsse, Carsten Schmidt-Samoa, Peter Dechent, Eva Irle Tags: Functional magnetic resonance imaging Source Type: research

Does Self-Rated Health Predict Dementia?
Conclusions: In cognitively intact older adults SRH predicts dementia. In older adults with CIND, SRH does not predict dementia. (Source: Journal of Geriatric Psychiatry and Neurology)
Source: Journal of Geriatric Psychiatry and Neurology - March 20, 2013 Category: Genetics & Stem Cells Authors: John, P., Montgomery, P. Tags: Articles Source Type: research

Increased masticatory activity and quality of life in elderly persons with dementia-a longitudinal matched cluster randomized single-blind multicenter intervention study
DiscussionThis research protocol investigates the effect of an intervention executed by daily caregivers. The intervention will increase masticatory activity, which is achieved by three different actions, (providing oral health care, increasing food consistency, or a combination of both). There is a certain amount of variety in the nature of the interventions due to local differences in nursing homes. This might be a scientific weakness in the study design; however, a practical implementation of any findings will be subject to the same factors, making this study design clinically relevant.Trial registrationNTR1561 (Source: BMC Neurology)
Source: BMC Neurology - March 16, 2013 Category: Neurology Authors: Roxane Anthea Francesca WeijenbergFrank LobbezooDirk Lucas KnolJori TomassenErik Johan Anton Scherder Source Type: research

The Role of Vitamin D in Alzheimer's Disease: Possible Genetic and Cell Signaling Mechanisms
In conclusion, vitamin D may play a beneficial role in AD. Calcitriol is the best vitamin D supplement for AD, because it is the active form of the vitamin D3 metabolite and modulates inflammatory cytokine expression. Therefore, further investigation of the role of calcitriol in AD is needed. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 14, 2013 Category: Geriatrics Authors: Luong, K. V. Q., Nguy{ecirctilde}n, L. T. H. Tags: Reviews Source Type: research

Treatment of trauma with lithium to forestall the development of posttraumatic stress disorder by pharmacological induction of a mild transient amnesia
Abstract: Posttraumatic stress disorder (PTSD) is a severe anxiety disorder that develops after exposure to trauma. Symptoms include persistent reexperiencing, persistent avoidance, persistent numbing, and persistent hyperarousal. Subsequent to trauma exposure, the onset of symptoms of an acute stress reaction can typically develop over varying amounts of time from days to months. Current pharmacotherapies for PTSD are available after symptoms manifest, and primarily consist of selective serotonin reuptake inhibitor (SSRI) antidepressants. There are currently no FDA approved pharmacological interventions available for the ...
Source: Medical Hypotheses - March 14, 2013 Category: Biomedical Science Authors: James Wallace Tags: Articles Source Type: research

Experimental Alzheimer's Drug Shows Promise, Study Finds
While not a 'wonder drug,' medication may help slow memory loss, researcher says (Source: WebMD Health)
Source: WebMD Health - March 12, 2013 Category: Consumer Health News Source Type: news

Sleep loss precedes Alzheimer's symptoms
(Washington University School of Medicine) Sleep is disrupted in people who likely have early Alzheimer's disease but do not yet have the memory loss or other cognitive problems characteristic of full-blown disease, researchers at Washington University School of Medicine in St. Louis report March 11 in JAMA Neurology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 11, 2013 Category: Global & Universal Source Type: news