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This page shows you the latest news and research items in this category.

Distribution of thalassemias and associated hemoglobinopathies identified by prenatal diagnosis in Taiwan.
CONCLUSION: In Taiwan, incidence and frequency of thalassemia genotypes were similar to those previously reported. The national program for screening pregnancies to control spread of thalassemia that resulted in a marked decline in the number of newborns with thalassemia major. Interestingly, prenatal diagnoses revealed 21.5% for thalassemia major, 50.2% for thalassemia minor, 28.3% normal comparison of thalassemia type distribution showed normal type increasing by 13.2% and major type decreasing by 14%. This unique and significant finding needs further clinical studies and discussion to explain such a phenomenon. PMID...
Source: Blood Cells, Molecules and Diseases - May 17, 2013 Category: Hematology Authors: Peng CT, Liu SC, Peng YC, Lin TH, Wang SJ, Le CY, Shih MC, Tien N, Lu JJ, Lin CY Tags: Blood Cells Mol Dis Source Type: research

Descriptive Epidemiology of Idiopathic Clubfoot
Abstract Clubfoot is a common structural malformation, occurring in approximately 1/1,000 live births. Previous studies of sociodemographic and pregnancy‐related risk factors have been inconsistent, with the exception of the strong male preponderance and association with primiparity. Hypotheses for clubfoot pathogenesis include fetal constraint, Mendelian‐inheritance, and vascular disruption, but its etiology remains elusive. We conducted a population‐based case–control study of clubfoot in North Carolina, Massachusetts, and New York from 2007 to 2011. Mothers of 677 clubfoot cases and 2,037 non‐malformed control...
Source: American Journal of Medical Genetics Part A - May 17, 2013 Category: Genetics & Stem Cells Authors: Martha M. Werler, Mahsa M. Yazdy, Allen A. Mitchell, Robert E. Meyer, Charlotte M. Druschel, Marlene Anderka, James R. Kasser, Susan T. Mahan Tags: Research Article Source Type: research

The role of noninvasive prenatal testing as a diagnostic versus a screening tool ‐ a cost‐effectiveness analysis
ConclusionsNIPT as a screening tool that requires a confirmatory amniocentesis is cost‐effective compared to its use as a diagnostic tool and leads to far fewer losses of normal pregnancies. This article is protected by copyright. All rights reserved. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - May 15, 2013 Category: Perinatology & Neonatology Authors: Mika Ohno, Aaron B. Caughey Tags: NIPT Special Issue Source Type: research

Echogenic focus in the fetal left ventricular cavity: Is it a false tendon?
Conclusion: False tendon should be taken into account as differential diagnosis of left ventricular echogenic focus in the fetus. Misinterpretation of false tendon as echogenic focus may cause unnecessary fetal invasive approach and maternal anxiety, especially when it arises with a background of borderline fetal findings and knowledge. (Source: Early Human Development)
Source: Early Human Development - May 12, 2013 Category: Perinatology & Neonatology Authors: Nahide Altug, A. Nuri Danisman Source Type: research

Prenatal control of nondeletional α‐thalassemia: first experience in mainland China
ConclusionImplementation of a prevention and control program accompanying with a referral system for prenatal diagnosis is technically feasible in southern China and a number of nondeletional Hb H disease have been prevented during the past 3 years of operation. This article is protected by copyright. All rights reserved. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - May 2, 2013 Category: Perinatology & Neonatology Authors: Jian Li, Ru Li, Jian‐Ying Zhou, Xing‐Mei Xie, Can Liao, Dong‐Zhi Li Tags: Original Article Source Type: research

Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight.
Conclusion. These findings suggest that the transmission of some periodontal pathogens from the oral cavity of the mother may cause adverse pregnancy outcomes. The results contribute to an understanding of the association between periodontal disease and PTLBW, but further studies are required to better clarify the possible relationship. PMID: 23638858 [PubMed - in process] (Source: Acta Odontologica Scandinavica)
Source: Acta Odontologica Scandinavica - May 1, 2013 Category: Dentistry Authors: Ercan E, Eratalay K, Deren O, Gur D, Ozyuncu O, Altun B, Kanlı C, Ozdemir P, Akıncıbay H Tags: Acta Odontol Scand Source Type: research

Monoamniotic Monochorionic Twins Discordant for Noncompaction Cardiomyopathy
We examined the prenatal course and subsequent pathologic correlation since ventricular morphogenesis may depend on early muscular contraction and blood flow. The monochorionic‐monoamniotic female twin pair was initially identified since one fetus presented with increased nuchal translucency. Complete heart block was later identified in the fetus with nuchal translucency who did not survive after delivery. In contrast, the unaffected twin had normal cardiac studies both prenatally and postnatally. Pathologic analysis of the affected twin demonstrated noncompaction of the left ventricle with dysplasia of the aortic and pu...
Source: American Journal of Medical Genetics Part A - May 1, 2013 Category: Genetics & Stem Cells Authors: Dianna Ng, Yosr Bouhlal, Philip C. Ursell, Joseph T.C. Shieh Tags: Research Article Source Type: research

Utilizing High‐Fidelity Crucial Conversation Simulation in Genetic Counseling Training
Abstract Genetics professionals are often required to deliver difficult news to patients and families. This is a challenging task, but one that many genetics trainees have limited opportunity to master during training. This is true for several reasons, including relative scarcity of these events and an understandable hesitation of supervisors allowing a trainee to provide such high stakes information. Medical simulation is effective in other health care disciplines giving trainees opportunities of “hands on” education in similar high stakes situations. We hypothesized that crucial conversations simulation would be effe...
Source: American Journal of Medical Genetics Part A - April 30, 2013 Category: Genetics & Stem Cells Authors: R. Lynn Holt, Nancy M. Tofil, Christina Hurst, Amber Q. Youngblood, Dawn Taylor Peterson, J. Lynn Zinkan, Marjorie Lee White, Jason L. Clemons, Nathaniel H. Robin Tags: Research Article Source Type: research

Birth of 16 healthy children after ICSI in cases of nonmosaic Klinefelter syndrome
This study provides further reassurance that KS men can father healthy children and that pre-implantation genetic diagnosis on embryos conceived with their sperm is not strongly indicated. However, until conclusive information is available, such couples should be offered extensive genetic counseling. STUDY FUNDING/COMPETING INTEREST(S) No external funding was obtained for the present study. None of the authors has any conflict of interest to declare. TRIAL REGISTRATION NUMBER Not applicable. (Source: Human Reproduction)
Source: Human Reproduction - April 16, 2013 Category: Reproduction Medicine Authors: Greco, E., Scarselli, F., Minasi, M. G., Casciani, V., Zavaglia, D., Dente, D., Tesarik, J., Franco, G. Tags: Andrology Source Type: research

A series of 238 Cytomegalovirus primary infections during pregnancy: description and outcome
ConclusionThe rate of materno fetal transmission is linearly correlated to the gestational age at infection. No severe case of congenital infection was observed if maternal infection occurred after 14 weeks of gestation. © 2013 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - April 2, 2013 Category: Perinatology & Neonatology Authors: O. Picone, C. Vauloup‐Fellous, A. G. Cordier, S. Guitton, M. V. Senat, F. Fuchs, J. M. Ayoubi, l. Grangeot Keros, A. Benachi Tags: Original Article Source Type: research

Soluble Fas and Fas-ligand levels in mid-trimester amniotic fluid and their associations with severe small for gestational age fetuses: a prospective observational study
Abstract: We aimed to determine the second-trimester amniotic fluid (AF) levels of soluble Fas (sFas) and Fas-ligand (FasL) and investigate their association with fetal growth. Therefore, sFas and FasL levels were measured by enzyme immunoassay in the AF of 21 small for gestational age (SGA), 13 large for gestational age (LGA), and 44 appropriate for gestational age (AGA) fetuses of pregnant women who underwent amniocentesis at between 15 and 22 weeks gestation. Our study results showed that sFas and FasL levels were detectable in AF. sFAS median (25th–75th centile) levels were 3.8 (2.8–4.6)ng/ml in SGA, 3.6 (3.1–4.5...
Source: Journal of Reproductive Immunology - April 1, 2013 Category: Allergy & Immunology Authors: N. Vrachnis, I. Dalainas, D. Papoutsis, E. Samoli, D. Rizos, Z. Iliodromiti, C. Siristatidis, P. Tsikouras, G. Creatsas, D. Botsis Source Type: research

Is thrombin activation predictive of subsequent preterm delivery?
Conclusion: Amniotic fluid levels of TAT complexes in the second trimester are elevated in women who subsequently deliver preterm, suggesting that thrombin generation may be involved in the various etiopathogenic mechanisms leading to preterm delivery. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 1, 2013 Category: OBGYN Authors: Alex C. Vidaeff, Manju Monga, Susan M. Ramin, George Saade, Haleh Sangi-Haghpeykar Tags: Obstetrics Source Type: research

Survey of second‐trimester maternal serum screening in Japan
ConclusionThis study revealed that most obstetricians in Japan do not provide their patients with sufficient information about MSS. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - March 20, 2013 Category: OBGYN Authors: Torayuki Okuyama, Junko Yotsumoto, Yumi Funato Tags: Original Article Source Type: research

Prenatal diagnosis of right aortic arch with mirror‐image branching without associated anomalies
Abstract A pregnant woman at 32 weeks of gestation was referred because of untypical visualization of a three‐vessel tracheal view. Detailed ultrasound examination demonstrated an abnormal position of descending aorta, positioned at the right‐front side of the spine at the level of four‐chamber view. The descending aorta was connected with left pulmonary artery through ductus arteriosus, which configured a vascular ring. Right aortic arch with mirror‐image branching without any associated anomaly was suspected prenatally. Amniocentesis showed no chromosomal abnormality. A male, 2440‐g infant was delivered vaginal...
Source: Journal of Obstetrics and Gynaecology Research - March 17, 2013 Category: OBGYN Authors: Masahiko Nakata, Yasuo Suzuki, Noriko Hotta, Takayo Sunasaka, Fumitaka Numa Tags: Case Report Source Type: research

Clinical experience of noninvasive prenatal testing with cell‐free DNA for fetal trisomies 21, 18, and 13, in a general screening population
ConclusionsNIPT has the potential to be a highly effective screening method as a standard test for risk assessment of fetal trisomies 21, 18, and 13 in general pregnant populations. © 2013 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - March 15, 2013 Category: Perinatology & Neonatology Authors: Genevieve Fairbrother, Shayla Johnson, Thomas J. Musci, Ken Song Tags: Original Article Source Type: research

Influence of prenatal maternal stress, maternal plasma cortisol and cortisol in the amniotic fluid on birth outcomes and child temperament at 3 months
We examined the pattern of associations and postulated pathways between physiological (cortisol plasma concentrations) and self-report indices (stress, anxiety) of maternal prenatal stress, cortisol in the amniotic fluid, birth outcomes and infant temperament at 3 months. The sample consisted of 158 women undergoing amniocentesis in the 2nd trimester of pregnancy. Questionnaire measures of maternal stress and anxiety were found to be unrelated to cortisol in plasma or amniotic fluid. Maternal cortisol was related to amniotic cortisol, which in turn was associated with lower birth weight. Birth weight predicted infant fear ...
Source: Psychoneuroendocrinology - March 8, 2013 Category: Psychiatry Authors: Eugenia Baibazarova, Cornelieke van de Beek, Peggy T. Cohen-Kettenis, Jan Buitelaar, Katherine H. Shelton, Stephanie H.M. van Goozen Tags: Articles Source Type: research

Balloon valvuloplasty for critical aortic stenosis in a fetus: a case report.
Abstract The mortality and morbidity of fetal aortic stenosis (AS) depend on the degree of the hemodynamic effects of the stenosis, and left ventricular (LV) adaptation, development and function during fetal life. In the case of critical AS, the development of hydrops and death in utero are well recognized entities. A 23-week gestation fetus was diagnosed with critical severe AS, cardiomegaly, a dilated LV with very poor contractility, and mitral regurgitation. There was a reversal of flow in the aortic arch through the ductus arteriosis and a reversed a-wave in the ductus venosus on Doppler examination. The fetus ...
Source: Turk Kardiyoloji Dernegi arsivi - March 1, 2013 Category: Cardiology Authors: Gül A, Saygılı A, Kavuncuoğlu S, Ceylan Y Tags: Turk Kardiyol Dern Ars Source Type: research

Omega-Shaped Variant of the Umbilical Artery: Prenatal Diagnosis and Outcome
The purpose of this series was to report on the observation of an anomalous course of the umbilical artery. Ten cases in a 25-month period are reported. An omega-shaped variant, coined the "omega sign," of one of two umbilical arteries or of a single umbilical artery was observed. In 2 cases, there were two umbilical arteries, one of them with the anomalous vessel. In 8 cases, the vessel was a single umbilical artery. In 1 case with a single umbilical artery and pericardial effusion, aneuploidy was found on amniocentesis. A second case was associated with multiple anomalies. A third case was associated with hypoplastic lef...
Source: Journal of Ultrasound in Medicine - February 26, 2013 Category: Radiology Authors: Shen, O., Rabinowitz, R., Malinger, G., Mazaki, E., Tsafrir, A. Tags: Case Series Source Type: research

Evaluation of antenatal umbilical coiling index at 16 to 21 weeks of gestation as a predictor of Down syndrome and other chromosomal defects
ConclusionsThe aUCI can be measured reliably and was related to gestational age at 16–21 weeks. The aUCI was not significantly associated with trisomy 21 or other chromosomal defects. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - February 22, 2013 Category: Radiology Authors: Christie P.M. Verkleij, Adriana C.C. van Oppen, Eduard J.H. Mulder, Monique W.M. de Laat, Esther Sikkel, Maria P.H. Koster, Ingeborg van der Tweel, Arie Franx, Gerard H.A. Visser Tags: Original Article Source Type: research

Evaluation of antenatal umbilical coiling index at 16 to 21 weeks of gestation as a predictor of Down syndrome and other chromosomal defects.
CONCLUSIONS: The aUCI can be measured reliably and was related to gestational age at 16-21 weeks. The aUCI was not significantly associated with trisomy 21 or other chromosomal defects. PMID: 23436607 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - February 22, 2013 Category: Radiology Authors: Verkleij CP, van Oppen AC, Mulder EJ, de Laat MW, Sikkel E, Koster MP, van der Tweel I, Franx A, Visser GH Tags: Ultrasound Obstet Gynecol Source Type: research

4379-20 AMNIOCENTESIS () Kit [Smiths Medical ASD, Inc.]
Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 8, 2013 Category: Drugs & Pharmacology Source Type: news

Noninvasive Prenatal Determination of Twin Zygosity by Maternal Plasma DNA Analysis [Molecular Diagnostics and Genetics]
CONCLUSIONS: Noninvasive prenatal determination of twin zygosity by maternal plasma DNA sequencing is feasible. It is also possible to determine the relative fractional fetal DNA concentrations for each fetus for dizygotic twin pregnancies. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2013 Category: Chemistry Authors: Qu, J. Z. Z., Leung, T. Y., Jiang, P., Liao, G. J. W., Cheng, Y. K. Y., Sun, H., Chiu, R. W. K., Chan, K. C. A., Lo, Y. M. D. Tags: Molecular Diagnostics and Genetics Source Type: research

Prenatal diagnosis and 47,XXY
Abstract In this contribution, we consider detection of 47,XXY by a variety of available methods. These include traditional invasive procedures, screening with maternal serum analytes and fetal ultrasound, and most recently cell‐free fetal DNA. Since its introduction in the late 1960s, prenatal genetic diagnosis has evolved greatly. Serendipitious detection of 47,XXY was not infrequent when prenatal genetic diagnosis routinely involved testing by the invasive procedures CVS and amniocentesis. In 2013 this is much less common and relatively few pregnancies in the U.S. and Europe are tested without prior screening protocol...
Source: American Journal of Medical Genetics Part C: Seminars in Medical Genetics - January 28, 2013 Category: Genetics & Stem Cells Authors: Joe Leigh Simpson, Carole Samango‐Sprouse Tags: Article Source Type: research

The impact of utilization of early aneuploidy screening on amniocenteses available for training in obstetrics and fetal medicine
ConclusionFirst‐trimester screening options reduce genetic amniocenteses available for training. Fetal medicine and general obstetrics training programs need to evaluate their clinical experience and determine whether simulation training methods are needed for education. © 2013 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - January 27, 2013 Category: Perinatology & Neonatology Authors: Nancy C. Rose, Danielle Lagrave, Brent Hafen, Marc Jackson Tags: Original Article Source Type: research

Management strategy in pregnancies with elevated second-trimester maternal serum alpha-fetoprotein based on a second assay
Conclusion: When maternal serum alpha-fetoprotein returns to a normal level on a second assay, the risk of adverse outcome significantly decreases, but these pregnancies are still at risk of complications and therefore need close surveillance. Repeat maternal serum alpha-fetoprotein assay allows identification of patients who should be offered amniocentesis to evaluate the risk of nephrotic syndrome and epidermolysis bullosa. Alpha-fetoprotein should be monitored in pregnancies associated with unexplained high maternal serum alpha-fetoprotein. A management strategy based on ultrasound examination, second maternal serum al...
Source: American Journal of Obstetrics and Gynecology - January 14, 2013 Category: OBGYN Authors: Emmanuel Spaggiari, Marie Ruas, Sophie Dreux, Anne-Sylvie Valat, Isabelle Czerkiewicz, Fabien Guimiot, Thomas Schmitz, Anne-Lise Delezoide, Françoise Muller Tags: Obstetrics Source Type: research

Non‐invasive prenatal testing of fetal whole chromosome aneuploidy by massively parallel sequencing
ConclusionsOur results indicate that non‐invasive detection of fetal chromosome aneuploidies for all 24 chromosomes in one single sequencing event is feasible. © 2013 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - January 9, 2013 Category: Perinatology & Neonatology Authors: Desheng Liang, Weigang Lv, Hua Wang, Liangpu Xu, Jing Liu, Haoxian Li, Liang Hu, Ying Peng, Lingqian Wu Tags: Original Article Source Type: research

Digit ratio (2D:4D) in newborns: Influences of prenatal testosterone and maternal environment
Conclusions: Sexual dimorphism at birth was only significant for the left hand, in contrast with reports of greater right hand dimorphism, suggesting that postnatal testosterone is determinant for 2D:4D stabilization. The lower 2D:4D ratios in mothers who had sons support claims that hormone levels in parents are influential for determining their children's sex. NB female's digit ratio, but not males', was associated to the level of AF testosterone. The mother's 2D:4D ratios were positively correlated with their daughters' 2D:4D, but the same was not observed for male NBs, suggesting that prenatal testosterone levels in ma...
Source: Early Human Development - January 8, 2013 Category: Perinatology & Neonatology Authors: T. Ventura, M.C. Gomes, A. Pita, M.T. Neto, A. Taylor Source Type: research

Market Shakeup in Developing Maternal Blood Prenatal Diagnostics
<p><a href="http://clk.about.com/?zi=1/1hc&zu=http://www.illumina.com/">Illumina</a>, the leading provider of <a href="http://clk.about.com/?zi=1/1hc&zu=http://biotech.about.com/od/researchlaboratory/a/The-Need-For-Cheaper-And-Faster-Dna-Sequencing.htm">high throughput gene sequencing</a> technology, announced <a href="http://clk.about.com/?zi=1/1hc&zu=http://investor.illumina.com/phoenix.zhtml?c=121127&p=irol-newsArticle&ID=1771460&highlight=">Monday</a> that it has agreed to purchase <a href=&q...
Source: About.com Biotech Biomedical - January 7, 2013 Category: Biotechnology Source Type: news

Aberrant right subclavian artery in Down syndrome fetuses
ConclusionsIn our study, the ARSA in combination with other ultrasound signs increased the risk for trisomy 21 by factor of 45, but the independent ability of ARSA as an isolated marker to predict fetal Trisomy 21 is unclear. © 2013 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - January 1, 2013 Category: Perinatology & Neonatology Authors: H. Fehmi Yazıcıoğlu, Osman Sevket, Hale Akın, Mehmet Aygün, Osman Nuri Özyurt, Ayse Karahasanoğlu Tags: Original Article Source Type: research

Hereditary persistence of alpha-fetoprotein: a rare cause for unexplained alpha-fetoprotein elevations in pregnancy.
Abstract Markedly elevated maternal serum alpha-fetoprotein (MSAFP) levels were found in a 26 year old healthy, nulliparous Polish woman during pregnancy. No fetal abnormalities were identified on targeted ultrasound and amniocentesis revealed normal amniotic fluid alpha-fetoprotein (AFP) values. Maternal ultrasound screening for liver and ovarian germ cell malignancies were also negative. The mother delivered a live, healthy female at term and a repeat maternal serum AFP postpartum remained markedly elevated, suggestive of hereditary persistence of alpha-fetoprotein. PMID: 23427373 [PubMed - in process] (Sourc...
Source: Connecticut Medicine - January 1, 2013 Category: Journals (General) Authors: Rood K, Stiller R Tags: Conn Med Source Type: research

A2745-22 AMNIOCENTESIS 22G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Dec 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 18, 2012 Category: Drugs & Pharmacology Source Type: news

Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM
Conclusion: Bioinformatic analysis of proteomics data allowed us to project likely biomolecular pathology resulting in pPROM complicated by MIAC and HCA. As inflammation is not a homogeneous phenomenon, we provide evidence for oxidative-stress-associated DNA damage and biomarkers of reactive oxygen species generation as factors associated with inflammation and proteolysis. (Source: Placenta)
Source: Placenta - December 17, 2012 Category: Reproduction Medicine Authors: V. Tambor, M. Kacerovsky, J. Lenco, G. Bhat, R. Menon Tags: Pathology Source Type: research

A2346-22 AMNIOCENTESIS () Kit [Smiths Medical ASD, Inc.]
Updated Date: Dec 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 13, 2012 Category: Drugs & Pharmacology Source Type: news

A2345-20 AMNIOCENTESIS 20G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Dec 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 13, 2012 Category: Drugs & Pharmacology Source Type: news

A2636 AMNIOCENTESIS () Kit [Smiths Medical ASD, Inc.]
Updated Date: Dec 4, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 4, 2012 Category: Drugs & Pharmacology Source Type: news

Prenatal cytogenetic diagnosis from fetal urine in lower urinary tract obstruction
ConclusionTraditional cytogenetic evaluation can be successfully performed on fetal urine samples in cases of lower urinary tract obstruction. (Source: Congenital Anomalies)
Source: Congenital Anomalies - December 1, 2012 Category: Genetics & Stem Cells Authors: Sina Haeri, Simone Hernandez Ruano, Leila M. S. Farah, Raquel Joffe, Rodrigo Ruano Tags: Short Communication Source Type: research

A1666-22 AMNIOCENTESIS () Kit [Smiths Medical ASD, Inc.]
Updated Date: Nov 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 27, 2012 Category: Drugs & Pharmacology Source Type: news

A1618 AMNIOCENTESIS 20G QUINCKE/22G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Nov 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 27, 2012 Category: Drugs & Pharmacology Source Type: news

A1807-20 AMNIOCENTESIS 20G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Nov 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 27, 2012 Category: Drugs & Pharmacology Source Type: news

Neonatal respiratory morbidity in twins versus singletons after elective prelabor caesarean section
Abstract: Objective: To compare the rate of neonatal respiratory morbidity in singletons versus twins delivered by pre-labour caesarean section.Study design: Uncomplicated pregnancies delivered by prelabor caesarean section at 34+0 to 37+6 weeks’ gestation were retrospectively selected. For both singletons and twins caesarean delivery was undertaken electively only after amniocentesis and if the lecithin/sphingomyelin ratio was ≥2. Neonatal respiratory morbidity was compared in twins versus singletons.Results: 241 singletons and 100 twin neonates were included. Overall neonatal respiratory morbidity was comparable betw...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 26, 2012 Category: OBGYN Authors: Tullio Ghi, Michela Nanni, Luca Pierantoni, Federica Bellussi, Maria Letizia Bacchi Reggiani, Giacomo Faldella, Nicola Rizzo Tags: Obstetrics and Maternal-Fetal Medicine Source Type: research

Skin Dimpling as a Complication of Amniocentesis: Histopathologic Findings.
PMID: 23177395 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - November 20, 2012 Category: Dermatology Authors: Monteagudo B, Del Pozo J, Suárez-Traba B, Sacristán F Tags: Actas Dermosifiliogr Source Type: research

Is hepatitis B virus transmitted via the male germ line? A seroepidemiological study in fetuses
Conclusions: The infection of fetuses with HBV from the spermatozoa of carrier fathers seems unlikely, especially in an area where pre-conception hepatitis B vaccination is routinely provided. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - November 14, 2012 Category: Infectious Diseases Authors: Qun-Xi Cai, Yi-Yang Zhu Tags: Original Reports Source Type: research

Influence of gravidity and foetal gender on the value of screening variables in the first trimester of pregnancy
Abstract: Objectives: Combined screening for chromosome abnormalities in the first trimester of pregnancy is based on maternal age, nuchal translucency (NT) and biochemical markers (PAPP-A and free β-hCG). We sought to assess the value of the variables used in the combined screening strategy taking into account maternal gravidity and foetal gender.Study design: Between July 1999 and December 2009, a total of 21,193 singleton pregnancies were screened for aneuploidy in the first trimester, in the Hospital Clínico San Carlos (Madrid, Spain). In the original database foetal gender data were available in 4370 euploid cases, ...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 12, 2012 Category: OBGYN Authors: Tamara Illescas, Cristina Fernández, Dolores Ortega, Miriam de la Puente, Pluvio Coronado, Joaquín Montalvo Tags: Obstetrics and Maternal-Fetal Medicine Source Type: research

Safe fetal platelet genotyping: new developments.
CONCLUSION: Two fetal PLT genotyping assays on maternal blood samples proved to be reliable as of 15 weeks of gestation, thereby avoiding invasive techniques such as amniocentesis. PMID: 23146000 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 12, 2012 Category: Hematology Authors: Le Toriellec E, Chenet C, Kaplan C Tags: Transfusion Source Type: research

A1052-22 AMNIOCENTESIS 22G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Nov 9, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 9, 2012 Category: Drugs & Pharmacology Source Type: news

4885-20 AMNIOCENTESIS 20G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 31, 2012 Category: Drugs & Pharmacology Source Type: news

4885-22 AMNIOCENTESIS 22G QUINCKE () Kit [Smiths Medical ASD, Inc.]
Updated Date: Oct 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 31, 2012 Category: Drugs & Pharmacology Source Type: news

Fetal axillary cystic hygroma: A novel association with triple X syndrome
CONCLUSIONThis is a novel description of axillary CH associated with triple X syndrome. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - October 26, 2012 Category: Perinatology & Neonatology Authors: Cantekin Iskender, Ebru Tarım, Tayfun Çok, Cem Yalcinkaya, Hakan Kalaycı, Feride Sahin Tags: Case Report Source Type: research

Simvastatin induces osteogenic differentiation in human amniotic fluid mesenchymal stem cells (AFMSC)
In conclusion, simvastatin could be used as an optional osteogenic induction agent for amniotic fluid‐derived mesenchymal stem cells. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - October 24, 2012 Category: Drugs & Pharmacology Authors: Felipe Lara Janz, Giovani Marino Favero, Milton Sérgio Bohatch, Adrianade Aguiar Debes, Sergio Paulo Bydlowski Tags: Original Article Source Type: research

Converting Amniotic Fluid-Derived Cells Into Endothelial Cells To Repair Damaged Blood Vessels In Heart Disease, Stroke, Diabetes And Trauma
A research team at Weill Cornell Medical College has discovered a way to utilize diagnostic prenatal amniocentesis cells, reprogramming them into abundant and stable endothelial cells capable of regenerating damaged blood vessels and repairing injured organs. Their study, published online in Cell, paints a picture of a future therapy where amniotic fluid collected from thousands of amniocentesis procedures yearly, during mid-pregnancy to examine fetal chromosomes, would be collected with the permission of women undergoing the test... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 22, 2012 Category: Consumer Health News Tags: Stem Cell Research Source Type: news