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Ambivalence toward undergoing invasive prenatal testing: an exploration of its originsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explores ambivalence toward undergoing amniocentesis among pregnant women with overall positive attitudes. Its novelty lies in the characterization of the type and origins of the ambivalence.Thirty-six women between 35 and 44 years of age were recruited from a US prenatal testing center to participate in structured telephone interviews.Thirty women chose to undergo testing. Attitudes toward undergoing amniocentesis were generally positive, although all participants simultaneously described feeling ambivalent. The women desired the information that amniocentesis could provide yet did not want to place their fetus...
Source: Prenatal Diagnosis - November 19, 2009 Category: Perinatology & Neonatology Authors: Julie Chevalier Sapp, Sara Chandros Hull, Shelby Duffer, Sarah Zornetzer, Erica Sutton, Theresa M. Marteau, Barbara Bowles Biesecker Source Type: journals

Amniotic fluid interleukin-18 at mid-trimester genetic amniocentesis: relationship to intraamniotic microbial invasion and preterm delivery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Elevated mid-trimester concentrations of AF IL-18 can identify women at risk for intraamniotic infection and spontaneous PTD. PMID: 19906019 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - November 13, 2009 Category: OBGYN Authors: Daskalakis G, Thomakos N, Papapanagiotou A, Papantoniou N, Mesogitis S, Antsaklis A Tags: BJOG Source Type: journals

Chorioamnionitis and Intrauterine Fetal Death after Second-Trimester AmniocentesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal Diagn Ther (DOI:10.1159/000257087) (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - November 4, 2009 Category: Perinatology & Neonatology Source Type: journals

Urocortin in Second Trimester Amniotic Fluid: Its Role as Predictor of Preterm LaborEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. These results suggest that urocortin concentrations in the amniotic fluid of genetic amniocentesis are not predictive of preterm labor and birth. (Source: Mediators of Inflammation)
Source: Mediators of Inflammation - November 4, 2009 Category: Biochemistry Source Type: journals

Interrogating the dynamics between power, knowledge and pregnant bodies in amniocentesis decision makingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A common assumption is that women who decline prenatal testing distrust biomedicine and trust embodied/experiential knowledge sources, while women who accept testing trust biomedicine and distrust embodied/experiential sources. Another major assumption about prenatal testing utilisation is that women who are open to abortion will undergo prenatal testing while those who are opposed to abortion will decline testing. Yet, previous research has produced inconsistent findings as to what, if anything, distinguishes women who accept or decline the offer of prenatal diagnosis. Analysing interviews with 147 pregnant women, this pa...
Source: Sociology of Health and Illness - November 4, 2009 Category: Global & Universal Authors: Susan Markens, Carole H. Browner, H. Mabel Preloran Source Type: journals

Geneticist Highlights Limitations of Prenatal TestingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dr. Brian Skotko, a geneticist at Children's Hospital Boston, has published research showing a decrease in the number of babies being born with Down syndrome since the introduction of prenatal testing. With new prenatal testing options on the horizon, his research highlights the problem between getting test results, and getting accurate information. The test results - either from amniocentesis or CVS - are fairly straightforward. Getting accurate information about the diagnosis of Down syndrome, on the other hand, is far from straightforward. Dr. Skotko's research found that expectant parents who received a prenatal diagno...
Source: About.com Down Syndrome - October 31, 2009 Category: Disability Source Type: consumer

Predicting lung maturity in preterm rupture of membranes via lamellar bodies count from a vaginal pool: a cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Counting of lamellar bodies in amniotic fluid from a vaginal pool may be used to predict fetal lung maturity. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 13, 2009 Category: Endocrinology Authors: Raed SalimNoah ZafranZohar NachumGali GarmiEliezer Shalev Source Type: journals

Familial adenomatous polyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(FAP) is characterized by the development of hundreds to thousands of adenomas in the rectum and colon during the second decade of life. FAP has an incidence at birth of about 1/8,300, manifests equally in both sexes, and accounts for less than 1% colorectal cancer (CRC) cases. In the European Union, prevalence has been estimated at 1/11,300-37,600. Most patients are asymptomatic for years until the adenomas are large and numerous, and cause rectal bleeding or even anemia, or cancer develops. Generally, cancers start to develop a decade after the appearance of the polyps. Nonspecific symptoms may include constipation or d...
Source: Orphanet Journal of Rare Diseases - October 11, 2009 Category: Internal Medicine Authors: Elizabeth HalfDani BercovichPaul Rozen Source Type: journals

An Interleukin-23 Binding Protein in Mid-Trimester Amniotic FluidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Interleukin-23 and IL-12 share a common p40 subunit and no inhibition of IL-12 was apparent. It appeared that a component of mid-trimester amniotic fluid specifically interacts with the p19 subunit unique to IL-23. Mid-trimester amniotic fluid reactivity with IL-23 may be a mechanism to limit intra-amniotic neutrophil-derived inflammation. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 6, 2009 Category: Allergy & Immunology Authors: Catherine Herway, Ann Marie Bongiovanni, Daniel Skupski, Steven S. Witkin Tags: Original Articles Source Type: journals

Predictive value of mid-trimester amniotic fluid high-sensitive C-reactive protein, ferritin, and lactate dehydrogenase for fetal growth restriction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Once the LDH value is confirmed, it could serve as a prediction factor for FGR at the time of genetic amniocentesis at gestational weeks 15-20. PMID: 19805955 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Borna S, Abdollahi A, Mirzaei F Tags: Indian J Pathol Microbiol Source Type: journals

The therapeutic management of a twin pregnancy complicated by the presence of cervical cancer, following laparoscopic staging and chemotherapy, with an emphasis on cisplatin concentrations in the fetomaternal compartments amnion fluid, umbilical cord, and maternal serumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): To our knowledge, this is the first report quantifying the amount of transplacental transport of cisplatin during pregnancy in vivo. One-tenth of the maternal serum concentration was detected in the amniotic fluid; the concentration of cisplatin in the umbilical cord was three times higher than in the amniotic fluid. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 18, 2009 Category: Reproduction Medicine Authors: Simone Marnitz, Alexander Schmittel, Juliane Bolbrinker, Frank-Peter Schmidt, Guus Fons, Karim Kalache, Achim Schneider, Christhardt Köhler Tags: Case report summaries Source Type: journals

Prenatal diagnosis and prognosis of triple X syndrome: 47, XXX.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report three cases of triple X syndrome that were diagnosed prenatally by genetic amniocentesis for advanced maternal age and have been observed from birth to age of 3 to 12 years. A description of their growth and development is presented. The birth weight was normal in all patients and one of them had facial dysmorphism with right microphtalmia and auricular septal defect. During the first 2 years of life, the neuromotor development of these infants was not distinguishable from chromosomally normal children. By 3 years of age, two patients have a moderate developmental delay in speech and language. One girl 12-year-ol...
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - September 14, 2009 Category: OBGYN Authors: Ben Hamouda H, Mkacher N, Elghezal H, Bannour H, Kamoun M, Soua H, Saad A, Souissi MM, Sfar MT Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: journals

Value of Amniocentesis versus Fetal Tissue for Cytogenetic Analysis in Cases of Fetal DemiseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal Diagn Ther (DOI:10.1159/000238114) (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - September 10, 2009 Category: Perinatology & Neonatology Source Type: journals

Experience with Intraamniotic Thyroxine Treatment in Nonimmune Fetal Goitrous Hypothyroidism in 12 Cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data confirm the feasibility and safety of intraamniotic L-thyroxine treatment for nonimmune fetal goitrous hypothyroidism. Although goiter size reduction is usually obtained, thyroid hormone status remains deficient at birth. Amniocentesis seems inadequate for monitoring fetal thyroid function. Further studies are needed to determine the optimal management of this disorder. PMID: 19737924 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 7, 2009 Category: Endocrinology Authors: Ribault V, Castanet M, Bertrand AM, Guibourdenche J, Vuillard E, Luton D, Polak M, Tags: J Clin Endocrinol Metab Source Type: journals

Opinion Two: A Case For Early GonadectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Androgen insensitivity is the most common cause of the undervirilized male and results from testosterone receptor abnormalities. Phenotypic presentation ranges from complete external feminization (complete androgen insensitivity) to ambiguous genitalia (partial androgen insensitivity) and finally infertile males. The diagnosis of complete androgen insensitivity is generally made as a result of primary amenorrhea, or after finding a testicle at inguinal herniorrhaphy. Earlier diagnosis is becoming increasingly more common with amniocentesis. There is little debate regarding gender of rearing in patients with complete androg...
Source: Journal of Pediatric and Adolescent Gynecology - September 7, 2009 Category: OBGYN Authors: Darcy A. Kiddo Tags: Opinions in Pediatric and Adolescent Gynecology Source Type: journals

Cervical length and gestational age at admission as predictors of intra-amniotic inflammation in preterm labor with intact membranesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate cervical length and gestational age as predictors of intra-amniotic inflammation in patients admitted because of preterm labor and intact membranes.Ninety-three pregnant women with preterm labor and intact membranes were included in our study. Cervical length was measured on admission by transvaginal sonography and transabdominal amniocentesis was performed within the first 48 h following admission. Positive amniotic fluid cultures defined intra-amniotic infection. Levels of intra-amniotic interleukin-6 (IL-6) were measured, and a receiver-operating characteristics (ROC) curve was constructed to determine the b...
Source: Ultrasound in Obstetrics and Gynecology - September 3, 2009 Category: Radiology Authors: M. Palacio, T. Cobo, J. Bosch, X. Filella, A. Navarro-Sastre, A. Ribes, E. Gratacós Source Type: journals

Cervical length and gestational age at admission as predictors of intra-amniotic inflammation in preterm labor with intact membranes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Cervical length and gestational age at admission can be used as a non-invasive method to assess the risk of intra-amniotic inflammation in preterm labor and intact membranes. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19731395 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - September 3, 2009 Category: Radiology Authors: Palacio M, Cobo T, Bosch J, Filella X, Navarro-Sastre A, Ribes A, Gratacós E Tags: Ultrasound Obstet Gynecol Source Type: journals

Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Perinatal Medicine 37 (5): 503-511 Abstract Objective: Recent observations have revealed an interaction between inflammation and angiogenesis, which may be mediated by angiopoietins and chemokines. Given the importance of inflammation in parturition, we sought to determine whether angiopoietin-2 (Ang-2) is present in amniotic fluid (AF) and if its concentration changes with gestational age, labor, and in intra-amniotic infection/inflammation (IAI) in patients with spontaneous preterm labor and intact membranes. Study design: This cross-sectional study included 486 patients in the following groups: 1) women in th...
Source: Journal of Perinatal Medicine - September 3, 2009 Category: Perinatology & Neonatology Source Type: journals

Embryo with XYY syndrome presenting with clubfoot: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Talipes equinovarus (clubfoot) is a skeletal anomaly of the embryo's legs, with a frequency of 1-3:1000 living born babies. It may occur as an independent anomaly, or as part of a syndrome with concomitant chromosomal abnormalities.XYY??syndrome is a quite rare sex chromosomal abnormality with 47, XYY karyotype. Prenatal diagnosis is usually accidental because the syndrome is not associated with increased prevalence of sonographically detectable defects. The possibility of co-existence of skeletal anomalies in embryos with 47, XYY karyotype is scant, with only a few cases reported in the literature.An amniocentesis was per...
Source: Cases Journal - September 1, 2009 Category: Journals (General) Source Type: journals

Guidelines on CMV congenital infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Perinatal Medicine 37 (5): 433-445 Abstract Congenital cytomegalovirus (CMV) infection occurs in 0.6–0.7% of all newborns and is the most prevalent infection-related cause of congenital neurological handicap. Vertical transmission occurs in around 30% of cases, but the fetus is not always affected. Symptomatic newborns at birth have a much higher risk of suffering severe neurological sequelae. Detection of specific IgG and IgM and IgG avidity seem to be the most reliable tests to identify a primary infection but interpretation in a clinical context may be difficult. If a seroconversion is documented or a fetal...
Source: Journal of Perinatal Medicine - August 31, 2009 Category: Perinatology & Neonatology Source Type: journals

Comprehensive amniotic fluid cytokine profile evaluation in women with a short cervix: which cytokine(s) correlates best with outcome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Among 25 cytokines, monocyte chemotactic protein-1 was most predictive of spontaneous preterm birth. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - August 31, 2009 Category: OBGYN Authors: Sean M. Keeler, Daniel G. Kiefer, Orion A. Rust, Anthony Vintzileos, Robert O. Atlas, Eran Bornstein, Nazeeh Hanna Tags: Selected papers from the 29th annual meeting (The Pregnancy Meeting) of the Society for Maternal-Fetal Medicine Source Type: journals

Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ObjectiveTo evaluate levels of matrix metalloproteinases (MMP) and their inhibitors (TIMP) in second trimester amniotic fluid of women with hypertensive disorders compared to normotensive women.Study Design: Amniotic fluid was obtained from 133 women undergoing genetic second trimester amniocentesis. Zymography was performed for MMP characterization and an MMP-2 ELISA kit was used to determine MMP-2 levels. TIMP-2 expression was evaluated using western blot. Results: Mean amniotic fluid MMP-2 and TIMP-2 levels were significantly higher in women who developed a hypertensive disorder compared to normotensive women (P (Source...
Source: Reproductive Biology and Endocrinology - August 22, 2009 Category: Endocrinology Authors: Michal LaveeShlomit GoldmanEtty Daniel-SpiegelEliezer Shalev Source Type: journals

Diagnostic performance of routine ultrasound screening for fetal abnormalities in an unselected Swedish population in 2000-2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine the detection rate of fetal malformations and chromosomal abnormalities and the rate of false-positive ultrasound diagnoses at routine ultrasound examinations carried out by specially trained midwives in an unselected pregnant population from 2000 to 2005, and to describe the consequences of true-positive and false-positive ultrasound diagnoses of fetal malformations.A retrospective analysis was undertaken of all babies born in Malmö, Sweden, between January 2000 and December 2005 by mothers residing in Malmö and of all fetuses with an ultrasound diagnosis of malformation made in the same time interval at th...
Source: Ultrasound in Obstetrics and Gynecology - August 17, 2009 Category: Radiology Authors: G. Romosan, E. Henriksson, A. Rylander, L. Valentin Source Type: journals

Diagnostic performance of routine ultrasound screening for fetal abnormalities in an unselected Swedish population in 2000-2005.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In a screening program consisting of one fetal anomaly scan at 18 weeks and another at 32 weeks the detection rate of major malformations in chromosomally normal fetuses was 68% with a detection rate of 37% at < 22 weeks. The corresponding detection rates of chromosomally abnormal fetuses were 46% and 33%. Fewer than one in 500 screened fetuses had an ultrasound diagnosis of an anomaly that was not confirmed after birth. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19688769 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - August 16, 2009 Category: Radiology Authors: Romosan G, Henriksson E, Rylander A, Valentin L Tags: Ultrasound Obstet Gynecol Source Type: journals

Is Cystatin C a Promising Parameter to Determine Postnatal Outcome of Prenatally Diagnosed Infravesical Obstruction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In fetuses with prenatal ultrasound signs consistent with infravesical obstruction urinary levels of cystatin C progressively increase in consecutive samples. Amniotic fluid may represent fetal urine sample in suspected prenatal infravesical obstruction in terms of cystatin C level. Amniotic fluid cystatin C level was significantly increased in obstructed fetuses compared to normal controls. Cystatin C level in amniotic fluid sample may be sufficient to provide prognostic information in prenatally diagnosed infravesical obstruction. (Source: The Journal of Urology)
Source: The Journal of Urology - August 16, 2009 Category: Urology & Nephrology Authors: Ömer Acar, Nihat Uluocak, Orhan Ziylan, İbrahim Kalelioğlu, Atıl Yüksel, Haluk Ander Tags: Pediatric Urology Source Type: journals

Fish based preimplantation genetic diagnosis to prevent DiGeorge syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s) The combination of preimplantation genetic diagnosis with fluorescence in-situ hybridization is recommended to prevent pregnancies with DiGeorge syndrome affected embryos in properly selected patients. Content Type Journal ArticleCategory CASE REPORTDOI 10.1007/s10815-009-9334-6Authors Shai Shefi, Petach Tikva Andrology Practice Petach Tikva IsraelGil Raviv, Tel Aviv University Male Infertility Unit, Urology Department, Chaim Sheba Medical Center, Tel Hashomer, Affiliated to the Sackler School of Medicine Tel Aviv IsraelShlomit Rienstein, Tel Aviv University The Danek Gertner Institute of...
Source: Journal of Assisted Reproduction and Genetics - August 12, 2009 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: journals

[Amniocentesis and viral risk (hepatitis B, C virus and HIV).]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Very few studies have properly addressed to the risk of fetal hepatitis B (HBV), hepatitis C (HCV) or human immunodeficiency virus (HIV) infection through amniocentesis. For HVB, this risk is low. However, knowledge of the maternal hepatitis B e antigen status is valuable in the counselling of risks associated with amniocentesis. For HCV, the risk is not well known but cannot be excluded. For HIV, it seems rational to propose a viral test before amniocentesis for patients with contamination's risk and to postpone the sampling in cases with positive results in order to obtain an undetectable HIV-1 RNA viral load. For th...
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - August 10, 2009 Category: OBGYN Authors: Ducarme G, Ceccaldi PF, Bernuau J, Luton D Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: journals

Blood test for mothers could save lives of hundreds of unborn babiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
• Risk-free screening may replace amniocentesis test • Diagnosis would use maternal blood sample The NHS is developing a simple blood test that could save the lives of hundreds of unborn babies who are put at risk when doctors try to establish whether they are developing healthily in the womb, the Guardian has learned.The test could put an end to the use of invasive procedures such as amniocentesis, which cause some women to miscarry.The Guardian has been given exclusive access to the NHS's £2m research into a new technology which, if successful, would benefit the thousands of women a year whose babies are identified ...
Source: Guardian Unlimited Science - August 9, 2009 Category: Science Authors: Denis Campbell Tags: Medical research Pregnancy Life and style Health NHS Down's syndrome UK news The Guardian Science Source Type: news

Blood test could save lives of hundreds of babiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
• Risk-free screening may replace amniocentesis test • Diagnosis would use maternal blood sample The NHS is developing a simple blood test that could save the lives of hundreds of unborn babies who are put at risk when doctors try to establish whether they are developing healthily in the womb, the Guardian has learned.The test could put an end to the use of invasive procedures such as amniocentesis, which cause some women to miscarry.The Guardian has been given exclusive access to the NHS's £2m research into a new technology which, if successful, would benefit the thousands of women a year whose babies are identified ...
Source: Guardian Unlimited Science - August 9, 2009 Category: Science Authors: Denis Campbell Tags: Medical research Pregnancy Life and style Health NHS Down's syndrome UK news The Guardian Science Source Type: news

4D vs 2D ultrasound-guided amniocentesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion.The 4D US, which allows the needle tip to be displayed in real time in three orthogonal planes simultaneously, thus providing reassurance that no fetal parts are in the needle path, did not offer any advantage over 2D US in guiding routine midtrimester amniocentesis and this new modality has not yet proved effective in reducing the number ofneedle insertions. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009 (Source: Journal of Clinical Ultrasound)
Source: Journal of Clinical Ultrasound - August 7, 2009 Category: Radiology Authors: Gabriele Tonni, Gabriele Centini, Lucia Rosignoli, Cindy Argento, Giovanni Centini Source Type: journals

Sonographic findings in a case of tetrasomy 9p associated with increased nuchal translucency and Dandy-Walker malformationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a 23-year-old pregnant woman, who underwent amniocentesis after ultrasound (US) examination in the first trimester which revealed a nuchal translucency thickness of 2.9 mm. Cytogenetic analysis revealed complete tetrasomy of the short arm of chromosome 9. Further US evaluation in the second trimester revealed Dandy-Walker malformation, ventriculomegaly, bilateral clubfoot, lip and palate clefts, arthrogryposis and hyperechoic kidneys with bilateral pelvic dilatation. At 30 weeks of gestation, a placental abruption was noted and a Cesarean section was performed. The infant died shortly after birth. A rev...
Source: Journal of Clinical Ultrasound - August 3, 2009 Category: Radiology Authors: Marcos Nakamura-Pereira, Luciana Carneiro do Cima, Juan Clinton Llerena Jr., Fernando Antonio Ramos Guerra, Fernando Maia Peixoto-Filho Source Type: journals

Hyaluronan modulates pro-inflammatory immune activity in the mid-trimester amniotic cavityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, intraamniotic HA levels are elevated in pregnancies at risk for adverse outcome and HA may be a component of the fetal response to immune alterations that threaten gestation. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - August 2, 2009 Category: Allergy & Immunology Authors: Devrim Sezen, Uma Perni, Catherine Herway, Ann Marie Bongiovanni, Daniel Skupski, Steven S. Witkin Tags: Clinical Studies Source Type: journals

Prenatal diagnosis of pallister-killian syndrome associated with pulmonary stenosis and right ventricular dilatation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pallister-Killian syndrome (PKS) is a rare disorder characterized cytogenetically by tetrasomy 12p for isochromosome of the short arm of chromosome 12. PKS is diagnosed by prenatal genetic analysis through chorionic villous sampling, genetic amniocentesis, and cordocentesis, or by chromosomal analysis of skin fibroblasts, but is not usually detected by chromosomal analysis of peripheral blood cells. Herein, we report a case of a gravida at 23 weeks gestation with pulmonary stenosis and right ventricular dilation of the heart which were detected by sonography. Fluorescence in situ hybridization and a multicolor banding ...
Source: The Korean Journal of Laboratory Medicine - July 31, 2009 Category: Laboratory Medicine Authors: Park IY, Shin JC, Kwon JY, Koo BK, Kim M, Lim J, Kim Y, Han K Tags: Korean J Lab Med Source Type: journals

Simple, cheap, practical and efficient amniocentesis training model made with materials found in every obstetrics clinicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - July 21, 2009 Category: Perinatology & Neonatology Authors: Emre Karasahin, Ibrahim Alanbay, Mutlu Ercan, Mufit Cemal Yenen, Murat Dede, [Idot]skender Ba[scedil]er Source Type: journals

An offer you can't refuse? Ethical implications of non-invasive prenatal diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ram Henn Genetic prenatal diagnosis (PND) for fetal aneuploidies has been an integral part of prenatal medicine for over 30 years. It is usually performed as a combination of initial non-invasive risk screening (NIRS) strategies, and suspicious results are followed by invasive diagnostic procedures such as amniocentesis. (Source: Nature Reviews Genetics)
Source: Nature Reviews Genetics - July 17, 2009 Category: Genetics & Stem Cells Authors: Dagmar SchmitzChristian NetzerWolfram Henn Tags: Research Highlight Source Type: journals

Androgen insensitivity syndrome after preimplantation genetic diagnosis for sex selection: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Although androgen insensitivity syndrome is very rare, it can occur in cases of PGD for sex selection. (Source: Fertility and Sterility)
Source: Fertility and Sterility - July 14, 2009 Category: Reproduction Medicine Authors: Zaid Kilani, Yahia Dajani, Eva Qaddomi, Lamia Haj Hassan Tags: Case report summaries Source Type: journals

Amniotic fluid urocortin, CRF, oestriol, dehydroepiandrosterone sulfate and cortisol concentrations at mid-trimester: putative relationship with preterm deliveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: Stress-related peptide and steroid hormones are involved in the pathogenesis of preterm delivery, even though their clinical usefulness as predictive markers of preterm delivery remains unclear. The present study evaluated whether mid-trimester amniotic fluid concentrations of stress-related peptides, that is corticothophin-releasing factor (CRF) and urocortin (Ucn) and feto-placental steroids (oestriol, DHEA-S and cortisol) correlated with preterm delivery.Study design: It is a retrospective case–control study. Healthy women (n=130) undergoing amniocentesis at mid-gestation for genetic indications, ...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - July 12, 2009 Category: OBGYN Authors: Michela Torricelli, Chiara Voltolini, Letizia Galleri, Giulia Biliotti, Alessia Giovannelli, Maria De Bonis, Flavio De Pascalis, Giovanni Centini, Felice Petraglia Tags: Obstetrics and Maternal-Fetal Medicine Source Type: journals

A large choroid plexus cyst diagnosed with magnetic resonance imaging in utero: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the nature of prenatal intracranial cysts should be fully evaluated and differentiated between choroid plexus cysts and other types of cysts. We believe that a detailed evaluation of detected cysts and other structural brain abnormalities are essential. Prenatal magnetic resonance scans clearly can decrease the need for risky procedures, such as an amniocentesis, in the evaluation of antenatal choroid plexus cysts. (Source: Cases Journal)
Source: Cases Journal - July 9, 2009 Category: Journals (General) Source Type: journals

Larger Hospital Units Have Lower Miscarriage Rates After Invasive Pregnancy TestsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study of more than 64,000 pregnant women has found that miscarriage rates following amniocentesis and chorionic villus sampling (CVS) - two invasive procedures to detect chromosomal abnormalities and birth defects - were 1.4 per cent and 1.9 per cent, respectively. (Source: Women's Health / OBGYN News From Medical News Today)
Source: Women's Health / OBGYN News From Medical News Today - July 8, 2009 Category: OBGYN Tags: Pregnancy / Obstetrics Source Type: news

Larger hospital units have lower miscarriage rates after invasive pregnancy testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Wiley-Blackwell) A study of more than 64,000 pregnant women has found that miscarriage rates following amniocentesis and chorionic villus sampling were 1.4 percent and 1.9 percent, respectively. The research also found that the number of procedures carried out by a department had a significant effect on miscarriage rates with lower rates in larger units. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 7, 2009 Category: Global & Universal Source Type: news

Evaluation of non-invasive prenatal RHD genotyping of the fetus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Non-invasive testing of multiple exons provides a robust method of assessing fetal RHD status, and provides a safer alternative to amniocentesis for the management of RhD-negative pregnant women who are isoimmunised. PMID: 19580531 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - July 5, 2009 Category: Journals (General) Authors: Hyland CA, Gardener GJ, Davies H, Ahvenainen M, Flower RL, Irwin D, Morris JM, Ward CM, Hyett JA Tags: Med J Aust Source Type: journals

Down syndrome in monochorionic twins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report such a case diagnosed prenatally. Maternal serum screening was performed at 15 weeks for a twin pregnancy which indicated a risk of greater than 1:50 for Down syndrome. The review of early ultrasonography confirmed monochorionic twins. Amniocentesis at 17 weeks' gestation was performed on one of the twin sacs, which confirmed Down syndrome. A screening scan at 19 weeks' gestation showed isolated absent nasal bones in both twins. Termination of pregnancy was performed subsequently. PMID: 19644615 [PubMed - in process] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - June 30, 2009 Category: Journals (General) Authors: Sin IL, Tan TY Tags: Singapore Med J Source Type: journals

Fetal trisomy 13 and 21 mosaicism diagnosed at amniocentesis: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - June 28, 2009 Category: Perinatology & Neonatology Authors: Agne Velthut, Maire Peters, Tiiu Roovere, Gerly Kilusk, Nina Horelli-Kuitunen, Marek [Scaron]ois, Andres Salumets Source Type: journals

Who should be allowed to perform amniocentesis and chorionic villus sampling?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19565531 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 28, 2009 Category: Radiology Authors: Alfirevic Z Tags: Ultrasound Obstet Gynecol Source Type: journals

The role of human beta defensins 2 and 3 in the second trimester amniotic fluid in predicting preterm labor and premature rupture of membranesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Second trimester amniotic fluid HBD2 might be a predictor of premature rupture of membranes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-009-1155-4Authors C. Iavazzo, University of Athens 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital Athens GreeceK. Tassis, “LITO” Maternity Hospital Fetal Medicine Unit Athens GreeceD. Gourgiotis, University of Athens 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital Athens GreeceM. Boutsikou, University of Athens 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital Athens GreeceS. B...
Source: Archives of Gynecology and Obstetrics - June 25, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess the fetal loss rate following amniocentesis and chorionic villus sampling (CVS).This was a national registry-based cohort study, including all singleton pregnant women who had an amniocentesis (n = 32 852) or CVS (n = 31 355) in Denmark between 1996 and 2006. Personal registration numbers of women having had an amniocentesis or a CVS were retrieved from the Danish Central Cytogenetic Registry, and cross-linked with the National Registry of Patients to determine the outcome of each pregnancy. Postprocedural fetal loss rate was defined as miscarriage or intrauterine demise before 24 weeks of gestation.The miscarria...
Source: Ultrasound in Obstetrics and Gynecology - June 5, 2009 Category: Radiology Authors: A. Tabor, C. H. F. Vestergaard, Ø. Lidegaard Source Type: journals

Biology of insulin-like factor 3 in human reproductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS INSL3 promises to become an important new diagnostic tool to characterize those men with late-onset hypogonadism and to add clinical diagnostic value at amniocentesis. (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 5, 2009 Category: OBGYN Authors: Ivell, R., Anand-Ivell, R. Tags: Reviews Source Type: journals

Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The miscarriage rates (i.e. spontaneous loss and procedure-related loss) after amniocentesis and CVS were 1.4% and 1.9%, respectively. This difference may be explained by the difference in gestational age at the time of the procedures. The miscarriage rate was inversely correlated with the number of procedures performed in a department. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19504504 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - June 4, 2009 Category: Radiology Authors: Tabor A, Vestergaard CH, Lidegaard O Tags: Ultrasound Obstet Gynecol Source Type: journals

Mid-trimester amniotic fluid C-reactive protein, ferritin and lactate dehydrogenase concentrations and subsequent risk of spontaneous preterm labourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Mid-trimester LDH is found to be quite effective in the prediction of preterm delivery. Pre-existing intrauterine inflammatory process early in gestation may be an important risk factor for preterm delivery. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - June 2, 2009 Category: OBGYN Authors: Sedigheh BORNA, Fatemeh MIRZAIE, Alireza ABDOLLAHI Source Type: journals

Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Down syndrome screening evolved from 2001-2007, with an increasing emphasis on first-trimester screening. With more efficacious screening, the number of invasive procedures has declined. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 21, 2009 Category: OBGYN Authors: Yu Ming Victor Fang, Peter Benn, Winston Campbell, Jay Bolnick, Anne Marie Prabulos, James F.X. Egan Tags: Genetics Source Type: journals