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Vincristine-Induced Unilateral Ptosis in a ChildEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vincristine is a vinca alkaloid used in combination with other agents in the treatment of solid tumors, lymphoma, and leukemia, as well as for idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia. A dose-limiting complication of vinca alkaloids is neurotoxicity. Vincristine is the oldest and also the most neurotoxic agent in this group. Described here is the case of a 4-year-old girl with unilateral palpebral ptosis. She has been diagnosed with precursor B-cell acute lymphoblastic leukemia. Ptosis was noted on the 45th day of therapy, and the last vincristine was administered on the 28th day of protocol 1. V...
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: Orhan Gursel, Erkan Sari, Demet Altun, A. Avni Atay, Ridvan Akin Tags: Case Reports Source Type: journals

Pernicious AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Pernicious AnemiaCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 11/20/2009 (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - November 20, 2009 Category: Cancer & Oncology Source Type: consumer

Pernicious AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Pernicious AnemiaCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 11/20/2009 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - November 20, 2009 Category: Gastroenterology Source Type: consumer

Pernicious AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Pernicious AnemiaCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 11/20/2009 (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - November 20, 2009 Category: Geriatrics Source Type: consumer

Pernicious AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Pernicious AnemiaCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 11/20/2009 (Source: MedicineNet Senior Health General)
Source: MedicineNet Senior Health General - November 20, 2009 Category: Geriatrics Source Type: consumer

Pernicious AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Pernicious AnemiaCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 11/20/2009 (Source: MedicineNet HIV General)
Source: MedicineNet HIV General - November 20, 2009 Category: Infectious Diseases Source Type: consumer

[Clinical significance of detecting serum erythropoietin in patients with leukemia.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: AL patients with anemia have significantly higher serum EPO levels than healthy individuals. In AL and IDA patients with moderate or severe anemia, EPO levels are inversely correlated to the level of hemoglobin, suggesting the integrity of the EPO synthesis mechanism in AL patients. Serum EPO level is also associated with bone marrow function in addition to hypoxia and hemoglobin levels, and hematopoiesis deficit in the early stage may be the main cause of anemia. PMID: 19923094 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Su N, Liu J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study the functional and structural role of a recently identified ADAMTS13 metalloprotease domain mutation S119F was investigated. Secretion from heterologous cells was hampered but not completely eliminated. Secreted S119F was active toward multimeric VWF and FRETS-VWF73 but with abnormal kinetics, having a significantly reduced overall catalytic rate (kcat; 0.88 ± 0.04 s–1 vs 2.78 ± 0.11 s–1) and slightly smaller Michaelis constant (KM; 1.4 ± 0.2µM vs 2.3 ± 0.3µM). A computational model of the metalloprotease domain demonstrates both steric and polar interaction...
Source: Blood - November 19, 2009 Category: Hematology Authors: Feys, H. B., Pareyn, I., Vancraenenbroeck, R., De Maeyer, M., Deckmyn, H., Van Geet, C., Vanhoorelbeke, K. Tags: Thrombosis and Hemostasis, Brief Reports Source Type: journals

The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafishEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The nuclear protein FOG-1 binds transcription factor GATA-1 to facilitate erythroid and megakaryocytic maturation. However, little is known about the function of FOG-1 during myeloid and lymphoid development or how FOG-1 expression is regulated in any tissue. We used in situ hybridization, gain- and loss-of-function studies in zebrafish to address these problems. Zebrafish FOG-1 is expressed in early hematopoietic cells, as well as heart, viscera, and paraspinal neurons, suggesting that it has multifaceted functions in organogenesis. We found that FOG-1 is dispensable for endoderm specification but is required for endoderm...
Source: Blood - November 19, 2009 Category: Hematology Authors: Amigo, J. D., Ackermann, G. E., Cope, J. J., Yu, M., Cooney, J. D., Ma, D., Langer, N. B., Shafizadeh, E., Shaw, G. C., Horsely, W., Trede, N. S., Davidson, A. J., Barut, B. A., Zhou, Y., Wojiski, S. A., Traver, D., Moran, T. B., Kourkoulis, G., Hsu, K., Tags: Hematopoiesis and Stem Cells Source Type: journals

Removal of erythropoietin from anaemia trauma practice guideline does not increase red blood cell transfusions and decreases hospital utilization costsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Introduction: We previously demonstrated that utilization of erythropoietin (r-EPO) did not significantly reduce blood utilization in trauma patients. We undertook this study to analyze blood utilization 1 year after r-EPO removal from our trauma service anaemia practice management guideline.Methods: Electronic records of patients admitted to the trauma service were retrospectively reviewed for units of packed red blood cells (pRBCs) transfused and for units of r-EPO administered 12 months before the initiation of an anaemia practice guideline (PRE), 12 months during the use of an anaemia guideline (GUIDE), and 1...
Source: Injury - November 19, 2009 Category: Orthopaedics Authors: A. Britton Christmas, Steven M. Camp, M. Craig Barrett, Thomas M. Schmelzer, H. James Norton, Toan T. Huynh, Michael H. Thomason, Ronald F. Sing Tags: Articles Source Type: journals

Anemia in Adults With Congenital Heart Disease Relates to Adverse OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: To assess the relation of anemia in noncyanotic adults with congenital heart disease (ACHD) to functional capacity and mortality.Background: Anemia is common in acquired heart failure and affects prognosis. The presence of anemia and its relation to outcome in ACHD remain unknown.Methods: Data were collected on consecutive noncyanotic ACHD patients attending our tertiary center between 2001 and 2006 in whom hemoglobin concentration was measured. Anemia was defined as hemoglobin concentration (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Konstantinos Dimopoulos, Gerhard-Paul Diller, Georgios Giannakoulas, Ricardo Petraco, Aikaterini Chamaidi, Evaggelia Karaoli, Michael Mullen, Lorna Swan, Massimo F. Piepoli, Philip A. Poole-Wilson, Darrel P. Francis, Michael A. Gatzoulis Tags: CONGENITAL HEART DISEASE Source Type: journals

Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 70 year old male with stage IV chronic lymphocytic leukemia complicated by aplastic anemia. Neurological examination and imaging revealed no significant abnormalities. At autopsy, the brain revealed multifocal cysts and free tachyzoites of Toxoplasma gondii with diffuse microglial nodules and no necrosis. To the best of our knowledge, this case represents the first report of the "encephalitic" form of toxoplasmosis in a non-AIDS patient. PMID: 19918334 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Abedalthagafi M, Rushing EJ, Garvin D, Cheson B, Ozdemirli M Tags: Int J Clin Exp Pathol Source Type: journals

Spontaneous liver rupture in a patient with peliosis hepatis: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver failure. Here, we present a young male patient with aplastic anemia, who had received long-term treatment with oxymetholone. The patient suffered from sudden onset of intra-abdominal hemorrhage with profuse hemoperitoneum. The patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative months. We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility ...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Choi SK, Jin JS, Cho SG, Choi SJ, Kim CS, Choe YM, Lee KY Tags: World J Gastroenterol Source Type: journals

Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival.A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetricians stage III, stage IV, or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose, relative time, and relative dose intensity. Treatment cycles [ge]7 were defined as treatment completion.Although black patients ...
Source: Cancer - November 19, 2009 Category: Cancer & Oncology Authors: John H. Farley, Chunqiao Tian, G. Scott Rose, Carol L. Brown, Michael Birrer, John I. Risinger, J. Tate Thigpen, Gini F. Fleming, Holly H. Gallion, G. Larry Maxwell Source Type: journals

FAIR-HF: Symptom Improvement, Functional Gains Follow Correction of Iron Deficiency in Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The randomized, placebo-controlled study's intriguing wrinkle: the benefits after 24 weeks of treatment with an injectable form of iron were independent of whether the patients were anemic. Heartwire (Source: Medscape Med Students Headlines)
Source: Medscape Med Students Headlines - November 18, 2009 Category: Universities & Medical Training Tags: Cardiology Source Type: info

Postop Anemia in High-CV-Risk Patients: No CV Gains From Fixed Hemoglobin Target in TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 18, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

FAIR-HF: Intravenous iron improves chronic heart failure outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intravenous iron treatment improves multiple clinical outcomes in patients with chronic heart failure and reduced left ventricular ejection fraction, regardless of whether or not they also have anemia, according to data from the FAIR-HF study. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 18, 2009 Category: Cardiology Source Type: news

The relationship of Plasmodium falciparum humoral immunity with HIV-1 immunosuppression and treatment efficacy in ZambiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HIV-1 affects humoral responses to AMA-1, but seems to marginally or not affect humoral responses to other merozoite antigens and VSAs. The latter were important for controlling parasite density and predict treatment outcome. (Source: Malaria Journal)
Source: Malaria Journal - November 18, 2009 Category: Infectious Diseases Authors: Jean-Pierre Van geertruydenErika Van EijkFrancisca YosaatmadjaWebster KasongoModest MulengaUmberto D'AlessandroStephen Rogerson Source Type: journals

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. This placebo-controlled trial randomly assigned such patients to receive darbepoetin alfa or placebo. The two composite end points were death or cardiovascular disease and death or end-stage renal disease. Darbepoetin alfa did not reduce either outcome and was associated with an increased risk of stroke. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Pfeffer, M. A., Burdmann, E. A., Chen, C.-Y., Cooper, M. E., de Zeeuw, D., Eckardt, K.-U., Feyzi, J. M., Ivanovich, P., Kewalramani, R., Levey, A. S., Lewis, E. F., McGill, J. B., McMurray, J. J.V., Parfrey, P., Parving, H.-H., Remuzzi, G., Singh, A. K., Tags: ORIGINAL ARTICLES Source Type: journals

Treatment of Anemia in Chronic Kidney Disease -- Strategies Based on EvidenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anemia associated with chronic kidney disease and end-stage renal disease is due, in large part, to reduced production of renal erythropoietin and abnormalities in extracellular-fluid volume homeostasis.1 Moreover, anemia and ... (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 18, 2009 Category: Internal Medicine Authors: Marsden, P. A. Tags: EDITORIALS Source Type: journals

FAIR-HF: Intravenous iron improves chronic heart failure outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intravenous iron treatment improves multiple clinical outcomes in patients with chronic heart failure and reduced left ventricular ejection fraction, regardless of whether or not they also have anemia, according to data from the FAIR-HF study. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 18, 2009 Category: Internal Medicine Source Type: news

Dose reduction of epoetin-alpha in the prevention of chemotherapy-induced anaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Dose reduction was as effective as fixed doses in anaemia prophylaxis but reduced the amount of prescribed epoetin substantially. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0773-5Authors François Lüthi, University Hospital–CHUV BH06 Centre Pluridisciplinaire d’Oncologie Rue du Bugnon 46 1011 Lausanne SwitzerlandMiklos Pless, University of Basel Department of Oncology Basel SwitzerlandSerge Leyvraz, University Hospital–CHUV BH06 Centre Pluridisciplinaire d’Oncologie Rue du Bugnon 46 1011 Lausanne SwitzerlandBeat Biedermann, University of Basel Departm...
Source: Supportive Care in Cancer - November 17, 2009 Category: Cancer & Oncology Tags: Supportive Care in Cancer Source Type: journals

Anaemia is an independent predictor of death in patients hospitalized for acute heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Anaemia is a frequent co-morbidity in patients with acute heart failure. Moderate to severe anaemia is an independent predictor of death in these patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-009-0092-3Authors Stephan von Haehling, Charité Medical School Applied Cachexia Research, Department of Cardiology Campus Virchow-Klinikum, Augustenburger Platz 1 13353 Berlin GermanyJoerg C. Schefold, Charité Medical School Department of Nephrology and Intensive Care Medicine Campus Virchow-Klinikum Berlin GermanyLea Majc Hodoscek, General Hospital Murska Sobota Depa...
Source: Clinical Research in Cardiology - November 17, 2009 Category: Cardiology Tags: Clinical Research in Cardiology Source Type: journals

Video Day in Review from AHA 2009 with Dr. Melissa Walton-Shirley: Monday, November 16Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Join Dr. Walton-Shirley for a review of ARBITER 6-HALTS, Primary PCI in Massachusetts, high ionizing radiation, soybeans and omega-3 fatty acid, video games, anemia and transfusion, and darbepoetin alfa. Medscape Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 17, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

No improvement in post-op CV events with liberal RBC transfusion strategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A liberal strategy of red blood cell transfusion in cases of moderate anemia does not result in better postoperative cardiovascular outcomes compared with a more restrictive strategy of transfusion based primarily on symptomatic anemia in elderly surgical patients, FOCUS trial results show. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 17, 2009 Category: Internal Medicine Source Type: news

AHA: Correcting Iron Helps in CHF, Anemia or Not (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ORLANDO (MedPage Today) -- Treating iron deficiency in heart failure patients makes patients feel better even in the absence of anemia, according to a randomized trial. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 17, 2009 Category: Cardiology Source Type: news

AHA: Stroke, VTE More Common with Darbepoetin (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ORLANDO (MedPage Today) -- Treating patients with diabetes, kidney disease and anemia with the colony stimulating factor darbepoetin (Aranesp) to improve their hemoglobin levels appears to cause more problems than it solves, researchers reported here. (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - November 17, 2009 Category: Urology & Nephrology Source Type: news

FAIR-HF: Symptom improvement, functional gains follow correction of iron deficiency in heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The randomized, placebo-controlled study's intriguing wrinkle: the benefits after 24 weeks of treatment with an injectable form of iron were independent of whether the patients were anemic. (Source: theHeart.org)
Source: theHeart.org - November 17, 2009 Category: Cardiology Source Type: info

Anemia TREATment fails to yield CV benefits, ups stroke riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risks of using the erythropoiesis-stimulating agent, darbepoetin alpha, to treat anemia in patients with Type 2 diabetes and chronic kidney disease far outweigh any modest benefits, according to data from the Trial to Reduce Cardiovascular Events with Aranesp Therapy. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 17, 2009 Category: Cardiology Source Type: news

No improvement in post-op CV events with liberal RBC transfusion strategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A liberal strategy of red blood cell transfusion in cases of moderate anemia does not result in better postoperative cardiovascular outcomes compared with a more restrictive strategy of transfusion based primarily on symptomatic anemia in elderly surgical patients, FOCUS trial results show. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 17, 2009 Category: Cardiology Source Type: news

Role of Latent Feline Leukemia Virus Infection in Nonregenerative Cytopenias of CatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nonregenerative cytopenias such as nonregenerative anemia, neutropenia, and thrombocytopenia in cats with feline leukemia virus (FeLV) antigen are assumed to be caused by the underlying FeLV infection. In addition, cats with negative FeLV antigen-test results that have cytopenias of unknown etiology often are suspected to suffer from latent FeLV infection that is responsible for the nonregenerative cytopenias. The purpose of this study was to assess the role of latent FeLV infection by polymerase chain reaction (PCR) in bone marrow of cats with nonregenerative cytopenias that had negative FeLV antigen test results in blood...
Source: Journal of Veterinary Internal Medicine - November 17, 2009 Category: Veterinary Research Authors: B. Stützer, F. Müller, M. Majzoub, H. Lutz, C.E. Greene, W. Hermanns, K. Hartmann Source Type: journals

Anemia and Iron Deficiency -- New Therapeutic Targets in Heart Failure?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(No abstract is available for this citation) (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 17, 2009 Category: Internal Medicine Authors: Dec, G. W. Tags: EDITORIALS Source Type: journals

A Pilot Study for Combination Chemotherapy Using Gemcitabine and S-1 for Advanced Pancreatic Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Combination therapy with gemcitabine and S-1 using the modified 4-week schedule was well tolerated and efficacious for advanced pancreatic cancer. PMID: 19923869 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - November 17, 2009 Category: Cancer & Oncology Authors: Nakai Y, Isayama H, Sasaki T, Sasahira N, Ito Y, Kogure H, Togawa O, Matsubara S, Arizumi T, Yagioka H, Yashima Y, Kawakubo K, Mizuno S, Yamamoto K, Hirano K, Tsujino T, Ijichi H, Toda N, Tada M, Kawabe T, Omata M Tags: Oncology Source Type: journals

The Utility of Therapeutic Drug Monitoring for Ribavirin in Patients with Chronic Hepatitis C--A Critical Review (December) (CE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is conflicting evidence about the existence of a correlation between ribavirin concentrations and virologic response or development of toxicity. This inconsistent evidence, coupled with the currently employed effective strategies that maximize sustained virologic response and minimize development of anemia, precludes the utility of TDM for ribavirin. PMID: 19920162 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 17, 2009 Category: Drugs & Pharmacology Authors: Chan AH, Partovi N, Ensom MH Tags: Ann Pharmacother Source Type: journals

Diabetic acido-ketosis revealing thiamine-responsive megaloblastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the cases of two infants, aged 4 and 5 months, hospitalized for diabetic ketoacidosis requiring insulin therapy. Laboratory tests revealed megaloblasic anemia, thrombocytopenia and normal thiamine level. Neurosensorial investigations showed bilateral deafness and ophthalmic involvement. Treatment with oral thiamine normalized hematological disorders and controlled diabetes; however, thiamine therapy had no impact on neurosensorial disorders. PMID: 19922902 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - November 17, 2009 Category: Endocrinology Authors: Bouyahia O, Ouderni M, Ben Mansour F, Matoussi N, Khaldi F Tags: Ann Endocrinol (Paris) Source Type: journals

Postop anemia in high-CV-risk patients: No CV gains from fixed hemoglobin target in trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A randomized trial found no protection from in-hospital cardiovascular events with a strategy of blood transfusions to maintain hemoglobin above 10 g/dL, compared with a more conservative approach to transfusion therapy, in patients with CV disease or risk factors who underwent hip surgery. (Source: theHeart.org)
Source: theHeart.org - November 16, 2009 Category: Cardiology Source Type: info

Potential utility of the new Sysmex XE 5000 red blood cell extended parameters in the study of disorders of iron metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1411-1416 Abstract Background: New erythrocyte parameters are reported by the Sysmex XE 5000 analyzer. This instrument measures the hemoglobin (Hb) content of individual red cells, calculates the percentage of hypochromic red cells (%Hypo He) and the percentage of hyperchromic red cells (%Hyper He) and quantifies the proportion of marginally sized erythrocytes (%Micro R and %Macro R). The goals of the study were to establish the reference range for erythrocyte extended parameters, their value in different types of anemia and to investigate their reliability in the study o...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Oxaliplatin: Haemolytic anaemia: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Peginterferon--2a/ribavirin: Sudden hearing loss and anaemia: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Clinical Trial Summary: Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT — Presented at AHA 2009)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although erythropoiesis-stimulating agents (ESAs) are widely used in patients with anemia and chronic kidney disease (CKD) who are not on dialysis, randomized data to support this approach are not available. The TREAT trial sought to test the hypothesis that the use of ESAs in patients with diabetes. . . (Source: Cardiosource)
Source: Cardiosource - November 16, 2009 Category: Cardiology Source Type: organizations

Anti-anemia drugs linked to VTE among patients with cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Erythropoiesis-stimulating agents are associated with an increased risk for venous thromboembolism, but not mortality, in elderly patients with cancer, study findings indicate. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - November 16, 2009 Category: Cancer & Oncology Source Type: news

Drugs to Lower Anemia Risk Linked to Pulmonary EmbolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of erythropoiesis-stimulating agents to reduce anemia risk has rapidly increased since their approval to nearly half of advanced cancer patients undergoing chemotherapy, but they are associated with a higher risk of deep vein thrombosis and pulmonary embolism while having no effect on the rate of blood transfusion, according to a study published online Nov. 10 in the Journal of the National Cancer Institute. (Source: Modern Medicine)
Source: Modern Medicine - November 16, 2009 Category: Journals (General) Source Type: info

Anti-anemia drugs linked to VTE among patients with cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Erythropoiesis-stimulating agents are associated with an increased risk for venous thromboembolism, but not mortality, in elderly patients with cancer, study findings indicate. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: news

Can intravenous iron therapy meet the unmet needs created by the new restrictions on erythropoietic stimulating agents?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2008, after reports of an association between erythropoietic stimulating agent (ESA) therapy and the potential for either thrombotic cardiovascular events or more rapid tumor progression in some cancers, the Food and Drug Administration changed the product labeling for ESAs, adding a black box warning as well as more restrictive indications, especially in oncology patients. In addition the Centers for Medicare and Medicaid Services has placed significant restrictions on payments for ESA therapy. These new limitations on ESA have led to increased use of transfusions in anemic cancer patients. This increase in allogen...
Source: Transfusion - November 16, 2009 Category: Hematology Authors: Shander A, Spence RK, Auerbach M Tags: Transfusion Source Type: journals

LA BioMed To Launch Study Of Testosterone In Older MenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) has announced that it will participate in a large national study of the effectiveness of testosterone as a treatment for anemia, cardiovascular disease, decreased vitality, impaired memory and sexual function, loss of muscle mass and other health conditions that affect older men. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2009 Category: Consumer Health News Tags: Men's health Source Type: news

LA BioMed To Launch Study Of Testosterone In Older MenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) has announced that it will participate in a large national study of the effectiveness of testosterone as a treatment for anemia, cardiovascular disease, decreased vitality, impaired memory and sexual function, loss of muscle mass and other health conditions that affect older men. (Source: Endocrinology News From Medical News Today)
Source: Endocrinology News From Medical News Today - November 14, 2009 Category: Endocrinology Tags: Men's health Source Type: news

Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we demonstrated that OSM and LIF can induce hepcidin expression mainly through the JAK/STAT pathways. Further studies are warranted to evaluate the clinical significance of OSM and LIF in the development of anemia in various inflammatory diseases. PMID: 19915946 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - November 14, 2009 Category: Hematology Authors: Kanda J, Uchiyama T, Tomosugi N, Higuchi M, Uchiyama T, Kawabata H Tags: Int J Hematol Source Type: journals

Female Zebra Finches (Taeniopygia guttata) Are Chronically but Not Cumulatively “Anemic” during Repeated Egg Laying in Response to Experimental Nest PredationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effect of repeated cycles of egg production in response to experimental nest predation (egg removal) on hematological traits in female zebra finches (Taeniopygia guttata). We predicted that if the negative effect of egg production on hematocrit and hemoglobin concentration was cumulative, with anemia being proportional to reproductive effort, then females laying more clutches, or laying successive clutches without recovery during incubation, would show greater reproductive anemia. In contrast, if females maintain hematocrit and hemoglobin concentration at some minimum functional level ind...
Source: Physiological and Biochemical Zoology - November 13, 2009 Category: Zoology Tags: article Source Type: journals

Deferasirox (Exjade) for the treatment of iron overload.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy in both adult and pediatric patients with transfusional iron overload. The clinical development program has demonstrated the efficacy of deferasirox for up to 4.5 years of treatment in patients with various underlying anemias, including beta-thalassemia, myelodysplastic syndromes, sickle cell disease, aplastic anemia, and other rare anemias. In addition to reducing key indicators of total body iron levels (serum ferritin, liver iron concentration, and toxic labile plasma iron), deferasirox has also demonstrated the ability to remove...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Cappellini MD, Taher A Tags: Acta Haematol Source Type: journals

Mitochondrial iron metabolism and sideroblastic anemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sideroblastic anemias are a heterogeneous group of disorders, characterized by mitochondrial iron overload in developing red blood cells. The unifying characteristic of all sideroblastic anemias is the ring sideroblast, which is a pathological erythroid precursor containing excessive deposits of non-heme iron in mitochondria with perinuclear distribution creating a ring appearance. Sideroblastic anemias may be hereditary or acquired. Hereditary sideroblastic anemias are caused by defects in genes present on the X chromosome (mutations in the ALAS2, ABCB7, or GRLX5 gene), genes on autosomal chromosomes, or mitochondrial...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Sheftel AD, Richardson DR, Prchal J, Ponka P Tags: Acta Haematol Source Type: journals