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Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies. (Source: Sarcoma)
Source: Sarcoma - November 17, 2009 Category: Cancer & Oncology Source Type: journals

A case report of primary gingival angiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports clinico-pathological features and CT image finding of a case of primary angiosarcoma in the upper gingival and a review of previously reported cases of primary gingival angiosarcomas including the present case. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - November 14, 2009 Category: ENT & OMF Authors: Yuka Uchiyama, Shumei Murakami, Mitsunobu Kishino, Souhei Furukawa Tags: Online Only Article Source Type: journals

Soft tissue sarcomas with complex genomic profilesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurr...
Source: Virchows Archiv - November 12, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Transient response of cardiac angiosarcoma to paclitaxelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present here the case of a patient with primary cardiac angiosarcoma that highlights the misdiagnosis at clinical presentation, current diagnostic modalities and a possible new treatment using paclitaxel for cardiac angiosarcoma. (Source: European Journal of Cancer Care)
Source: European Journal of Cancer Care - November 11, 2009 Category: Cancer & Oncology Authors: E. CASTILLA, I. PASCUAL, F. RONCALÉS, E. AGUIRRE, A. DEL RÍO Source Type: journals

Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer. Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients. However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations. Predisposing conditions include environmental exposures to chemical or radioactive sources. Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy. The latency for radiation-associated mammary angiosarcoma is rel...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Lucas DR Tags: Arch Pathol Lab Med Source Type: journals

Thorium dioxide: Primary cerebral angiosarcoma in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Treatment and Outcomes in Adult Patients with Primary Cardiac Sarcoma: The British Columbia Cancer Agency ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients with nonmetastatic cardiac sarcoma amenable to complete resection experienced improved survival. However, the high overall rates of disease progression and mortality highlight the need for more effective local and systemic treatments that may be used in conjunction with surgery to improve patient outcomes. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0734-8Authors Pauline T. Truong, British Columbia Cancer Agency Radiation Therapy Program, Vancouver Island Centre Victoria BC CanadaStuart O. Jones, British Columbia Cancer Agency Radiation...
Source: Annals of Surgical Oncology - October 15, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide (232ThO2) that emits alpha-particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X-ray fluorescence spectrometry (XRF) were ...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Yoichiro Yamamoto, Junichi Chikawa, Yoshinobu Uegaki, Nobuteru Usuda, Yoshikazu Kuwahara, Manabu Fukumoto Source Type: journals

A Case of Primary Cardiac Angiosarcoma: Extensive Right Atrial Wall Reconstruction with Autologous PericardiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 48-year-old man affected by angiosarcoma of the right atrium who presented with subacute cardiac tamponade. Extensive resection of the atrial wall infiltrated by the tumor, followed by autologous pericardial free atrial wall reconstruction, was successfully carried out. In spite of the optimal early outcome, the patient died 15 months later because of multiple osteal metastases. (J Card Surg ****;**:**-**) (Source: Journal of Cardiac Surgery)
Source: Journal of Cardiac Surgery - October 11, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Filippo Benassi, Antonino Maiorana, Francesco Melandri, Guglielmo Stefanelli Source Type: journals

[Microdialysis monitoring of a free omentum flap.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an application on a greater omentum free flap. CASE REPORT: A 77 year old female patient was operated for a vertex angiosarcoma. A large loss of vertex substance (175cm(2)) was rebuilt with a greater omentum free flap. Monitoring included hourly clinical observation (color, temperature, aspect), and flap surveillance using microdialysis CMA 60((R)) catheter. The first value was obtained 1h 30 after revascularization. The following recordings were made every hour for 48hours, then every 2hours for the next two days, then every 4hours. The following parameters were assessed: glucose (G), lactate (L), and pyruvate (...
Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale - October 11, 2009 Category: ENT & OMF Authors: Sury F, Orry D, Parmentier J, Goga D, Laure B Tags: Rev Stomatol Chir Maxillofac Source Type: journals

Epithelioid angiosarcoma: A neoplasm with potential diagnostic challengesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, the patient is a 24-year-old man presenting with testicular pain, a pelvic mass, and innumerable liver nodules. Immediate interpretation of the needle core biopsies of the pelvic mass and liver lesions initially favored a poorly differentiated adenocarcinoma. Unusual positive immunohistochemical stains for CD30 and CK7 ultimately led the investigation toward a tumor of mesenchymal origin. Further, immunohistochemical evaluation demonstrated positive CD31 and Factor VIII staining and established the final diagnosis of epithelioid angiosarcoma. The tumor cells were negative for CD34, CK20, alpha-fetoprotein, ...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: Christine F. Lin, Denis DeFrias, Xiaoqi Lin Source Type: journals

Angiosarcoma of skull base in a 1-year-old child—A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Angiosarcoma is a rare tumour of endothelial cell origin whilst malignant skull base tumours are highly unusual in paediatric patients. This case reports an angiosarcoma involving the clivus and basi-sphenoid region of the skull base, in a 1-year-old boy. This tumour is extremely rare in childhood, particularly in this site. The histological features were consistent with a high-grade haemangioendothelioma, categorised as an angiosarcoma [1]. The characteristics of this rare malignancy and the challenges in its management are discussed. This is the youngest reported patient, to our knowledge, with an angiosarcoma ...
Source: International Journal of Pediatric Otorhinolaryngology - October 5, 2009 Category: ENT & OMF Authors: Gayathri Mandya Renukaswamy, Simone J. Boardman, Neil J. Sebire, Benjamin E.J. Hartley Tags: Case reports Source Type: journals

Vinyl chloride and the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainment of unequivocal diagnoses. In the largest studies lack of data meant that confounding diseases such as viral hepatitis or alcoholic liver disease could not be assessed. At best, the increase in risk is minimal, based on more than 22,000 exposed workers and more than 640,000 person years of observation.Howeve...
Source: Journal of Hepatology - October 1, 2009 Category: Gastroenterology Authors: Morris Sherman Tags: Review Source Type: journals

Hypervascular Liver LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypervascular hepatocellular lesions include both benign and malignant etiologies. In the benign category, focal nodular hyperplasia and adenoma are typically hypervascular. In addition, some regenerative nodules in cirrhosis may be hypervascular. Malignant hypervascular primary hepatocellular lesions include hepatocellular carcinoma, fibrolamellar carcinoma, and peripheral cholangiocarcinoma. Vascular liver lesions often appear hypervascular because they tend to follow the enhancement of the blood pool; these include hemangiomas, arteriovenous malformations, angiosarcomas, and peliosis. While most gastrointestinal maligna...
Source: Seminars in Ultrasound CT and MRI - September 23, 2009 Category: Radiology Authors: Aya Kamaya, Katherine E. Maturen, Grace A. Tye, Yueyi I. Liu, Naveen N. Parti, Terry S. Desser Source Type: journals

Rectal Angiosarcoma After Adjuvant Chemoradiotherapy for Adenocarcinoma of the Rectum [DIAGNOSIS IN ONCOLOGY]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - September 20, 2009 Category: Cancer & Oncology Authors: Tardio, Najera, Alemany, Martin, Castano, Perez-Regadera Tags: Diagnosis & Staging, Rhabdo & Other Soft Tissue Sarcomas: DIAGNOSIS IN ONCOLOGY Source Type: journals

Hematuria: The Presenting Symptom of an Angiosarcoma of the Inferior Vena CavaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 41-year-old white male experienced 3 episodes of gross hematuria in 2 weeks. With the exception of nonspecific and nonlocalized abdominal discomfort the patient claimed to be asymptomatic. However, he had noticed an unintentional weight loss of approximately 15 lbs during the last 9 months. (Source: The Journal of Urology)
Source: The Journal of Urology - September 16, 2009 Category: Urology & Nephrology Authors: Erich K. Lang, Ernest Rudman, Ivan Colon, Richard J. Macchia Tags: Radiology Page Source Type: journals

Cardiac and gingival metastasis after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelioid angiosarcoma: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a unique case of cardiac and gingival metastases developing 4 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelial angiosarcoma. Initial treatment remains total abdominal hysterectomy with bilateral salpingo-oophorectomy. Limited distant metastases may be surgically resected in selected cases in order to improve quality of life or to prevent sudden death in untreated patients. Optimal chemotherapy regimens must be determined. Content Type Journal ArticleCategory CommunicationDOI 10.1007/s10397-009-0514-2Authors Olivier Donnez, Cliniques Univer...
Source: Gynecological Surgery - September 16, 2009 Category: OBGYN Tags: Gynecological Surgery Source Type: journals

KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiosarcomas (AS) represent a heterogeneous group of malignant vascular tumors occurring not only in different anatomic locations but also in distinct clinical settings, such as radiation or associated chronic lymphedema. Although representing only 1% to 2% of soft tissue sarcomas, vascular sarcomas provide unique insight into the general process of tumor angiogenesis. However, no molecular candidates have been identified to guide a specific therapeutic intervention. By expression profiling, AS show distinct up-regulation of vascular-specific receptor tyrosine kinases, including TIE1, KDR, SNRK, TEK, and FLT1. Full sequen...
Source: Cancer Research - September 13, 2009 Category: Cancer & Oncology Authors: Antonescu, C. R., Yoshida, A., Guo, T., Chang, N.-E., Zhang, L., Agaram, N. P., Qin, L.-X., Brennan, M. F., Singer, S., Maki, R. G. Tags: Priority Reports Source Type: journals

Cytogenetic analysis of a primary bone angiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma. The biologic significance of this translocation is not clear; however, the 1p21 locus is in the region of colony stimulating factor (CSF-1), which may play a role in tumorigenesis, as has been described in pigmented villonodular synovitis and tenosynovial giant cell tumor. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - September 7, 2009 Category: Genetics & Stem Cells Authors: Jennifer B. Dunlap, R. Ellen Magenis, Craig Davis, Eleanor Himoe, Atiya Mansoor Tags: Original articles Source Type: journals

[Original articles] Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The diagnosis of MLL continues to be challenging, in particular for pathologists. Awareness of this entity, clinical correlation and gross pathological correlation are essential in the separation of this distinctive pseudosarcoma from its various morphological mimics. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - September 3, 2009 Category: Pathology Authors: Manduch, M, Oliveira, A M, Nascimento, A G, Folpe, A L Tags: Immunology (including allergy) Original articles Source Type: journals

Outcome of Locally Recurrent and Metastatic AngiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Locally recurrent AS is treatable, but outlook for metastatic AS is favorable only with isolated lymphatic spread and taxol treatment. Background. Angiosarcoma (AS) is a rare soft tissue sarcoma with... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - September 1, 2009 Category: Cancer & Oncology Source Type: journals

Palliative surgical treatment of primary cardiac angiosarcoma complicated with recurrent tamponadeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - August 30, 2009 Category: Cancer & Oncology Authors: Javier Gualis, Mario Castaño, Jesús Gómez-Plana, Pilar Mencía, David Alonso Source Type: journals

[Images in Thorax] Small cell lung cancer mimicking a pulmonary venous angiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Thorax)
Source: Thorax - August 27, 2009 Category: Respiratory Medicine Authors: Morjaria, J B, Choong, C K, Amsha, K, Stewart, S, Wells, F C, Rintoul, R C Tags: Images in Thorax Source Type: journals

Cardiac Angiosarcoma with Cardiac Tamponade Diagnosed as a Ruptured Aneurysm of the Sinus ValsalvaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the case of a 56-year-old woman with a right atrial angiosarcoma. The patient presented with impending cardiac tamponade caused by right atrial perforation, but was misdiagnosed as a ruptured aneurysm of the sinus valsalva based on findings of a continuous murmur and an aorta to right atrium shunt by echocardiography. In the emergent operation that ensued, we found a right atrial perforation and a right coronary artery fistula to the right atrium. Coronary artery fistula is a rare complication of primary cardiac angiosarcoma, and a continuous murmur is also extremely rare as a clinical finding o...
Source: Japanese Journal of Clinical Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Yoshitake, I., Hata, M., Sezai, A., Niino, T., Unosawa, S., Shimura, K., Kasamaki, Y., Minami, K. Tags: Case Report Source Type: journals

[Pulmonary Ewing Sarcoma/Primitive Neuroectodermal Tumor: A Case Report and a Review of the Literature.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a 22-year-old woman with Ewing sarcoma/PNET diagnosed following histologic, immunohistochemical, and in situ hybridization studies of a bronchial biopsy specimen. Radiography, ventilation-perfusion scintigraphy, and a bone marrow biopsy confirmed that the tumor was not metastatic. The patient was started on a chemotherapy regimen of vincristine, actinomycin, cyclophosphamide, doxorubicin, ifosfamide, and etoposide and responded well. She is now being seen regularly at our outpatient clinic. PMID: 19656607 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - August 2, 2009 Category: Respiratory Medicine Authors: Suárez Antelo J, Rodríguez García C, Montero Martínez C, Verea Hernando H Tags: Arch Bronconeumol Source Type: journals

Postradiation cutaneous vascular tumors of the breast: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postradiation vascular tumors fall into two categories: (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner. Postradiation vascular tumors not only present a therapeutic problem for clinicians, but they present an increasingly common diagnostic dilemma for pathologists. Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial. It appears that, in at least some cases, angiosarcoma ca...
Source: Seminars in Diagnostic Pathology - August 1, 2009 Category: Pathology Authors: Joshua Weaver, Steven D. Billings Source Type: journals

Pseudoangiomatous stromal hyperplasia of the breast.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pseudoangiomatous stromal hyperplasia is a relatively common lesion of the breast. In general, it is less commonly found as a clinically palpable mass and is more commonly found as incidental microscopic foci. It is a benign proliferative, probably neoplastic, hormonally driven process of the mammary stromal myofibroblasts. The clinical, radiologic, and cytologic findings can resemble those of fibroadenoma. Histologically, it can be confused with low-grade angiosarcoma. The exact etiology of pseudoangiomatous stromal hyperplasia is still controversial, but a neoplastic process of the stromal myofibroblasts, with a horm...
Source: Archives of Pathology and Laboratory Medicine - July 31, 2009 Category: Laboratory Medicine Authors: AbdullGaffar B Tags: Arch Pathol Lab Med Source Type: journals

Angiosarcoma of the scalpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Manjiri Das Gupta, Nilay Chakrabarti, Pravin Agrawal, Swati NarurkarIndian Journal of Plastic Surgery 2009 42(1):118-121Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case o...
Source: Indian Journal of Plastic Surgery - July 30, 2009 Category: Cosmetic Surgery Authors: Manjiri Das Gupta, Nilay Chakrabarti, Pravin Agrawal, Swati Narurkar Source Type: journals

Definition of the features of acquired elastotic hemangioma reporting the clinical and histopathological characteristics of 14 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Acquired elastotic hemangioma is a distinctive variant of hemangioma which should be differentiated from other cutaneous vascular tumors with a hobnail endothelial pattern, including angiosarcoma. The expression of D2-40 in most cases suggests a lymphatic origin of this acquired vascular proliferation. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - July 13, 2009 Category: Pathology Authors: A. Martorell-Calatayud, N. Balmer, O. Sanmartín, J. L. Díaz-Recuero, O. P. Sangueza Source Type: journals

Radiation-induced angiosarcoma following treatment of metastatic melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - July 12, 2009 Category: Pathology Authors: RK Hejmadi, C Walker, A Rashid, JR Marsden Source Type: journals

Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Primary hepatic angiosarcoma appears as a solitary or multiple, hypervascular lesions with heterogeneously early and progressive enhancement on CT and angiography. Although TAE may be the primary procedure for achieving emergent bleeding control caused by the rupture of hepatic angiosarcomas, TACE may be effective for treating patients with a dominant hepatic angiosarcoma with or without intrahepatic metastases. (Source: Clinical Radiology)
Source: Clinical Radiology - July 9, 2009 Category: Radiology Authors: Y.S. Park, J.H. Kim, K.W. Kim, I.S. Lee, H.-K. Yoon, G.-Y. Ko, K.-B. Sung Tags: Original Articles Source Type: journals

Thrombocytopenia as first manifestation of splenic angiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0778-7Authors Simon Raffel, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin GermanyBert Hildebrandt, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin GermanyChristian Grieser, Charité Campus Virchow Klinikum Department of Radiology Augustenburger Platz 1 13353 Berlin GermanyStefan Pahl, Charité Campus Mitte Institute of Pathology Charitéplatz 1 10117 Berlin GermanyIsrid Sturm, Charité Campus Virchow Klinikum Department of...
Source: Annals of Hematology - July 1, 2009 Category: Hematology Tags: Annals of Hematology Source Type: journals

Postoperative outcomes in intimal aortic angiosarcoma: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a 74-year-old woman with intimal angiosarcoma that manifested with the triad of congestive heart failure, acute renal failure, and abdominal angina. A review of the literature and discussion of postoperative outcomes follows. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - June 29, 2009 Category: Surgery Authors: Saila P. Nicotera, Hector F. Simosa, David R. Campbell Tags: From the New England Society for Vascular Surgery Source Type: journals

Angiosarcoma of the scalpEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gupta Manjiri Das, Chakrabarti Nilay, Agrawal Pravin, Narurkar SwatiIndian Journal of Plastic Surgery 2009 42(1):118-121Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case o...
Source: Indian Journal of Plastic Surgery - June 29, 2009 Category: Cosmetic Surgery Authors: Gupta Manjiri Das, Chakrabarti Nilay, Agrawal Pravin, Narurkar Swati Source Type: journals

[Sarcomas] Phase II Study of Sorafenib in Patients With Metastatic or Recurrent SarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas. Further evaluation of sorafenib in these and possibly other sarcoma subtypes appears warranted, presumably in combination with cytotoxic or kinase-specific agents. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Maki, D'Adamo, Keohan, Saulle, Schuetze, Undevia, Livingston, Cooney, Hensley, Mita, Takimoto, Kraft, Elias, Brockstein, Blachere, Edgar, Schwartz, Qin, Antonescu, Schwartz Tags: Clinical Trials, Chemotherapy, Translational Oncology, Rhabdo & Other Soft Tissue Sarcomas: Source Type: journals

[Sarcomas] Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This is the first phase II study of a new agent in sarcoma to include sufficient patients with each of the common histologic subtypes to permit generalizable conclusions. The BHM is an effective method for studying rare diseases and their subtypes, when it is reasonable to assume that their response rates are exchangeable. Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Chugh, Wathen, Maki, Benjamin, Patel, Myers, Priebat, Reinke, Thomas, Keohan, Samuels, Baker Tags: Chemotherapy, Chemotherapy Sarcomas Source Type: journals

Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas [Sarcomas]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas. Further evaluation of sorafenib in these and possibly other sarcoma subtypes appears warranted, presumably in combination with cytotoxic or kinase-specific agents. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Maki, D'Adamo, Keohan, Saulle, Schuetze, Undevia, Livingston, Cooney, Hensley, Mita, Takimoto, Kraft, Elias, Brockstein, Blachere, Edgar, Schwartz, Qin, Antonescu, Schwartz Tags: Clinical Trials, Chemotherapy, Translational Oncology, Rhabdo & Other Soft Tissue Sarcomas: Source Type: journals

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model [Sarcomas]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This is the first phase II study of a new agent in sarcoma to include sufficient patients with each of the common histologic subtypes to permit generalizable conclusions. The BHM is an effective method for studying rare diseases and their subtypes, when it is reasonable to assume that their response rates are exchangeable. Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Chugh, Wathen, Maki, Benjamin, Patel, Myers, Priebat, Reinke, Thomas, Keohan, Samuels, Baker Tags: Chemotherapy, Chemotherapy Sarcomas Source Type: journals

Outcome of Locally Recurrent and Metastatic AngiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Locally recurrent AS is often treatable; complete resection can potentially prolong survival. In contrast, metastatic patients have a grave prognosis; however, patients with isolated lymphatic spread and possibly those treated with taxol-based chemotherapeutic regimens have a favorable outcome. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0569-3Authors G. Lahat, University of Texas MD Anderson Cancer Center Department of Surgical Oncology Houston TX USAA. R. Dhuka, University of Texas MD Anderson Cancer Center Department of Surgical Oncology Houston T...
Source: Annals of Surgical Oncology - June 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Granular cell atypical fibroxanthoma: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of granular cell atypical fibroxanthoma of the scalp. The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man. Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm. Many of the cells had large irregular nuclei and atypical mitotic figures were present. Immunohistochemical stains were positive for CD68 and procollagen 1 and negative for cytokeratin, HMB-45 and S-100 protein. The granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarc...
Source: Journal of Cutaneous Pathology - June 17, 2009 Category: Pathology Authors: Natalie A. Wright, Crystal G. Thomas, Antoanella Calame, Clay J. Cockerell Source Type: journals

Secondary sarcomas after radiotherapy for breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angiosarcoma (AS) using the Surveillance, Epidemiology, and End Results (SEER) database.Women with BCa reported to SEER in 1973 to 2003 were included. Kaplan-Meier curves and proportional hazards models, reported as hazards ratios (HR) with 95% confidence intervals (95% CI), were used. Survival of patients who developed RT-associated AS was compared with that of patients with primary AS of the thorax and upper...
Source: Cancer - June 12, 2009 Category: Cancer & Oncology Authors: Carlos M. Mery, Suzanne George, Monica M. Bertagnolli, Chandrajit P. Raut Source Type: journals

[CASE STUDIES] Pulmonary Angiosarcoma Presenting as Spontaneous Recurrent HemothoraxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An incidental diagnosis of pulmonary angiosarcoma was made after surgical exploration for repeated episodes of bleeding in an 85-year-old woman. Spontaneous hemothorax is uncommon and deserves detailed investigation. (Source: Asian Cardiovascular and Thoracic Annals)
Source: Asian Cardiovascular and Thoracic Annals - June 10, 2009 Category: Cardiology Authors: Campione, Forte, Luzzi, Comino, Gorla, Terzi Tags: CASE STUDIES Source Type: journals

Pulmonary Angiosarcoma Presenting as Spontaneous Recurrent Hemothorax [CASE STUDIES]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An incidental diagnosis of pulmonary angiosarcoma was made after surgical exploration for repeated episodes of bleeding in an 85-year-old woman. Spontaneous hemothorax is uncommon and deserves detailed investigation. (Source: Asian Cardiovascular and Thoracic Annals)
Source: Asian Cardiovascular and Thoracic Annals - June 9, 2009 Category: Cardiology Authors: Campione, Forte, Luzzi, Comino, Gorla, Terzi Tags: CASE STUDIES Source Type: journals

Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with SunitinibEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each t...
Source: Sarcoma - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Spontaneous Regression of Pulmonary Metastases from Breast AngiosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a rare case of pulmonary metastases in a 72-year-old woman with metastatic breast angiosarcoma. She was diagnosed with a breast angiosarcoma in 2005 and underwent a total mastectomy and postoperative radiotherapy. Unfortunately, a year later she was found to have multiple lung and scalp metastases but in a view of her poor general fitness, she was not a candidate for chemotherapy and was kept on regular followup. Despite the absence of any treatment, the followup chest X-ray showed a significant reduction in the number and size of lung nodules and her scalp lesions regressed completely. Seven months after the di...
Source: Sarcoma - June 9, 2009 Category: Cancer & Oncology Source Type: journals

UNC scientists identify growth factor as possible cancer drug targetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of North Carolina School of Medicine) Scientists at the UNC Lineberger Comprehensive Cancer Center report finding a new angiogenesis protein, SFRP2, found in the blood vessels of numerous tumor sites, including breast prostate, lung, pancreas, ovarian, colon, kidney tumors and angiosarcomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2009 Category: Cancer & Oncology Source Type: news

Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, SFRP2 is a novel stimulator of angiogenesis that stimulates angiogenesis via a calcineurin/NFAT pathway and may be a favorable target for the inhibition of angiogenesis in solid tumors. [Cancer Res 2009;69(11):4621–8] (Source: Cancer Research)
Source: Cancer Research - June 1, 2009 Category: Cancer & Oncology Authors: Courtwright, A., Siamakpour-Reihani, S., Arbiser, J. L., Banet, N., Hilliard, E., Fried, L., Livasy, C., Ketelsen, D., Nepal, D. B., Perou, C. M., Patterson, C., Klauber-DeMore, N. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

Skin cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Skin cancer is the most common cancer worldwide. Skin cancers most often arise from the epidermis (basal cell carcinoma and squamous cell carcinoma), but cancer may arise from any structure in the skin, including from the melanocytes (melanoma), blood vessels (e.g. angiosarcoma), adnexal structures (e.g. malignant sweat gland tumours) and the connective tissue (e.g. dermatofibrosarcoma protuberans). The skin can also be the site of lymphoma and metastasis from internal cancers, including carcinoma of the breast, colon and lung. This contribution focuses on the most common skin cancers: melanoma and the ‘non-mel...
Source: Medicine - June 1, 2009 Category: Internal Medicine Authors: Stephanie Ogden, Nicholas R. Telfer Tags: Skin tumours Source Type: journals

[Primary breast angiosarcoma: Two cases report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary angiosarcoma is a rare type of breast cancer, the diagnosis is difficult to establish and it has the worst prognostic of all breast malignancies. Two cases of primary breast angiosarcoma have been observed at the centre Henry Kaplan of Tours and at the hospital La Source of Orleans since 2001. Based on a literature review, we analyse the epidemiological, pathological, clinical, diagnostic and treatment aspect of this type of cancer. Mastectomy is the reference treatment and the benefit of radiotherapy and chemotherapy remains to be demonstrated. PMID: 19410492 [PubMed - in process] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 31, 2009 Category: Cancer & Oncology Authors: Champeaux-Orange E, Bonneau C, Raharimanana B, Favre A, Ibrahim M, Breteau N Tags: Cancer Radiother Source Type: journals

[Primary angiosarcoma of the liver.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19581774 [PubMed - in process] (Source: Korean J Hepatol)
Source: Korean J Hepatol - May 31, 2009 Category: Gastroenterology Authors: Seok JY, Kim YB Tags: Korean J Hepatol Source Type: journals