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Primary antiphospholipid syndrome and hepatitis B and C infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Role of Tissue Factor in the Maternal Immunological Attack of the Embryo in the Antiphospholipid SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recurrent fetal loss affects 1–5% of women of childbearing age. Immunological mechanisms may account for 40% of recurrent miscarriages, and in particular, the antiphospholipid syndrome (APS) appears to be implicated in 7–25% of the cases. Because antiphospholipid (aPL) antibodies have thrombogenic properties, fetal loss in patients with APS has been ascribed to thrombosis of placental vessels. However, we have shown that inflammation, specifically activation of complement with generation of the anaphylotoxin C5a, is an essential trigger of fetal injury. Thrombosis and inflammation are linked in ...
Source: Clinical Reviews in Allergy and Immunology - November 18, 2009 Category: Allergy & Immunology Tags: Clinical Reviews in Allergy and Immunology Source Type: journals

Venous Thromboembolism in Young Female While on Oral Contraceptives: High Frequency of Inherited Thrombophilia and Analysis of Thrombotic Events in 400 Czech WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results confirm that venous thromboembolism is a multifactorial disease in which thrombophilia screening is needed in young symptomatic women on the pill with thrombosis. The results also emphasize the value of proper thromboprophylaxis in women while on oral contraceptive in situations of increased risk for venous thromboembolism. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 12, 2009 Category: Hematology Authors: Dulicek, P., Maly, J., Pecka, M., Beranek, M., Cermakova, E., Maly, R. Tags: Articles Source Type: journals

2010 ASN AbstractsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: VBD can enlarge to significant dimensions, producing compressive symptoms in the brainstem, as well as thrombosis and ischemic strokes. SACE of the dolichoectasia can be effective for the vessel reconstruction, to prevent progression of the dilatation, and other potential clinical events. 3. Three Case Reports of Multiple Carotid and/or Vertebral Artery Dissections in Female Mei Lu, Heather Gornik, Esteban Cheng Ching, Vikram Kashyap, Rishi Gupta Cleveland Clinic Foundation, Cleveland, OH 44195, United States Introduction: Multiple carotid and/or vertebral artery dissections are rare. However, patients with mul...
Source: Journal of Neuroimaging - November 11, 2009 Category: Radiology Source Type: journals

Thrombophilia investigation in Malaysian women with recurrent pregnancy lossEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Thrombophilia was identified in more than one-quarter (26.6% = 107/402) of the RPL subjects. APC-R not caused by FVL mutation was the most common thrombophilia marker in Malaysians, whereas in Caucasians it was the APC-R due to FVL mutation. The identification of FVL and PTG mutations in Malaysian women with RPL disputes prevailing evidences suggesting its non-occurrence in patients with Asian ancestries. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - November 9, 2009 Category: OBGYN Authors: Thiruchelvam Ayadurai, Sekaran Muniandy, Siti Zawiah Omar Source Type: journals

[Antiphospholipid syndrome - an update on diagnosis and treatment.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antiphospholipid syndrome (APS) was described by Hughes et al in 1986 and then by Harris et al in 1987. The symptoms of disease are related to the presence of autoantibodies directed against plasma and serum proteins that form complexes with phospholipids of cell membranes. The immunologic process involving vascular endothelium, thrombocytes and coagulation factors is responsible for enhancement of procoagulation mechanisms and as a result - venous and arterial thrombosis. Actual criteria of recognition of APS were published in 2006 as a result of 11(th) International Congress on Antiphospholipid Antibodies which was t...
Source: Pneumonologia i Alergologia Polska - November 6, 2009 Category: Respiratory Medicine Authors: Szturmowicz M Tags: Pneumonol Alergol Pol Source Type: journals

Thrombin Activatable Fibrinolysis Inhibitor and Clot Lysis Time in Pregnant Patients with Antiphospholipid Syndrome: Relationship with Pregnancy Outcome and ThrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Patients with APS have impairment in fibrinolysis evidenced by prolonged CLT at baseline. TAFI and CLT do not seem to be useful as markers of obstetric outcome or risk of thrombosis in patients with APS. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - November 6, 2009 Category: Allergy & Immunology Authors: Maria Angeles Martinez-Zamora, Dolors Tassies, Francisco Carmona, Gerard Espinosa, Ricard Cervera, Juan Carlos Reverter, Juan Balasch Tags: Original Articles Source Type: journals

Urgent Termination of Pregnancy in Pre-eclampsia and Panel of Antiphospholipid AntibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Supposed increase in various antiphospholipid antibodies (aPLs) levels due to the stress during the short time of admission and a need for a quick medical decision to terminate the pregnancy was not unambiguously proven, but our results are evidently influenced by the current urgent life-saving treatment. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - November 6, 2009 Category: Allergy & Immunology Authors: Libor Hradecky, Ivan Subrt, Zdenka Ulcova-Gallova Tags: Original Articles Source Type: journals

Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, women with thrombotic APS (Group 3) have higher rates of pregnancy complications than those with obstetric APS (Groups 1 and 2). Treatment with aspirin and LMWH is associated with improved outcomes for women with previous late fetal loss or early delivery due to placental dysfunction (Group 2). PMID: 19897518 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - November 6, 2009 Category: Rheumatology Authors: Bramham K, Hunt BJ, Germain S, Calatayud I, Khamashta M, Bewley S, Nelson-Piercy C Tags: Lupus Source Type: journals

Antiphospholipid antibodies in young Indian patients with strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions : APL, positive family history and smoking were significantly associated with stroke in the young. We advocate screening for APL in all young patients with stroke. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - November 2, 2009 Category: Internal Medicine Source Type: journals

Common infectious agents prevalence in antiphospholipid syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, 98 patients with antiphospholipid syndrome were screened for antibodies directed to several infectious agents. The main finding in this study is the significantly higher prevalence of IgM antibodies to toxoplasma and rubella. This novel finding suggests that these infections might be associated with antiphospholipid syndrome. As autoimmune diseases and, in particular, antiphospholipid syndrome are associated with infections, mainly the catastrophic type of the syndrome, this finding implies that a current infection with these agents, i.e. toxoplasma and rubella, might either be related to the pathogenesis of...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Zinger H, Sherer Y, Goddard G, Berkun Y, Barzilai O, Agmon-Levin N, Ram M, Blank M, Tincani A, Rozman B, Cervera R, Shoenfeld Y Tags: Lupus Source Type: journals

Antibody May Raise Heart Attack, Stroke Risks: Lupus anticoagulant said to be ‘a major risk factor for arterial thrombotic disease’ in young women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of lupus anticoagulant, an antiphospholipid antibody, increased the risk of stroke by 40-fold and of heart attack by 5-fold in a Dutch study that compared young women who had survived these conditions with a healthy control group. (Source: Family Practice News)
Source: Family Practice News - November 1, 2009 Category: Primary Care Authors: JANE SALODOF MacNEIL Tags: Cardiovascular Medicine Source Type: news

MI, Stroke Risk Soars With Lupus AnticoagulantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of lupus anticoagulant, an antiphospholipid antibody, increased the risk of stroke by 40-fold and of heart attack by 5-fold in a Dutch study that compared young women who had survived these conditions with a healthy control group. (Source: Cardiology News)
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: JANE SALODOF MacNEIL Tags: Epidemiology & Prevention Source Type: news

Peginterferon-/ribavirin: Antiphospholipid syndrome and cutaneous sarcoidosis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Combined central retinal artery and vein occlusion in a patient with systemic lupus erythematosus and antiphospholipid syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein a 35-year-old female patient displaying a transient and reversible process. Her best-corrected visual acuity improved from 6/60 to 6/8.6 1 day later, before the initiation of systemic corticosteroid and anti-coagulant treatment. The retina regained a normal appearance with her vision recovering to 6/6 2 weeks after the episode of temporary vision loss. Her rapid recovery suggests that continued anti-coagulation therapy and close follow-up to prevent severe complications and recurrent thrombosis is warranted. PMID: 19880552 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 30, 2009 Category: Rheumatology Authors: Chang PC, Chen WS, Lin HY, Lee HM, Chen SJ Tags: Lupus Source Type: journals

Distinct subtypes of myelitis in systemic lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken to determine whether SLE myelitis similarly encapsulates distinct syndromes.We analyzed a cohort of 22 patients with SLE and myelitis. Patients were assessed for neurologic variables related to myelitis and for clinical and serologic features of SLE. Magnetic resonance images of the spine, cerebrospinal fluid profiles, and autoantibody profiles were obtained.Eleven patients presented with signs of gray matter dysfunction (i.e., flaccidity and hyporeflexia), whereas 11 patients presented with signs of white matter dysfunction (i.e., spasticity and hyperreflexia). Patients with gray matter dysfuncti...
Source: Arthritis and Rheumatism - October 29, 2009 Category: Rheumatology Authors: J. Birnbaum, M. Petri, R. Thompson, I. Izbudak, D. Kerr Tags: Systemic Lupus Erythematosus Source Type: journals

Endothelial dysfunction in Iranian lupus patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Atherosclerosis has a high prevalence in systemic lupus erythematosus (SLE) patients and vascular endothelial dysfunction is the earliest stage of atherosclerosis. The aim of this study was to evaluate the prevalence of vascular endothelial dysfunction and its risk factors in SLE patients and to identify its correlation with disease activity, duration and concomitant conditions in these patients. A total of 84 female SLE patients and 18 healthy young women were included. The vascular endothelial function was evaluated via ultrasonographic assessment of the brachial artery diameter to determine flow-...
Source: Rheumatology International - October 23, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

Val247Leu polymorphism of β2 glycoprotein 1 gene may justify the genesis of anti β2GP1 antibodies and Antiphospholipid Syndrome in Multibacillary LeprosyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The prevalence of Val/Val homozygosis in leprosy group can partially justify the presence of anti-β2GP1 IgM antibodies in MB leprosy. The description of heterozygosis and Val/Val homozygosis in 7 patients with MB leprosy and thrombosis corroborates the implication of anomalous phenotype expression of β2GP1 and development of anti-β2GP1 antibodies, with consequent thrombosis and APS. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - October 23, 2009 Category: Dermatology Source Type: journals

Autoimmune diseases induced by biological agents A double-edged sword?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biological agents are increasingly used for a rapidly expanding number of rheumatic and systemic autoimmune diseases, with a growing number of reports of the paradoxical induction of autoimmune processes, overwhelmingly associated with anti-TNF agents. In this review, we analyze the clinical characteristics and outcomes of autoimmune diseases developing after biological therapies through a baseline Medline search as one of the objectives of the BIOGEAS project, created by the Spanish Society of Internal Medicine. The latest update of our registry (15 July 2009) included more than 800 cases of autoimmune diseases secon...
Source: Autoimmunity Reviews - October 22, 2009 Category: Allergy & Immunology Authors: Ramos-Casals M, Perez-Alvarez R, Diaz-Lagares C, Cuadrado MJ, Khamashta MA, Tags: Autoimmun Rev Source Type: journals

Autoimmunity and Recurrent Pregnancy LossesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The relationship between autoimmunity and reproduction has long been recognized. This relationship is bidirectional and includes many diverse issues, but in this review article, we focus on which autoimmune disturbances are the basic cause of recurrent pregnancy losses in patients with autoimmune diseases. The antiphospholipid antibodies seem to be clearly associated with recurrent miscarriage. Although there is no agreement on the mechanisms of recurrent pregnancy losses in patients with these antibodies, vasculopathy of the terminal spiral arteries may be implicated and there is a general consensu...
Source: Clinical Reviews in Allergy and Immunology - October 21, 2009 Category: Allergy & Immunology Tags: Clinical Reviews in Allergy and Immunology Source Type: journals

Mechanisms of antiphospholipid antibody-associated pregnancy complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) are at high risk for recurrent spontaneous miscarriage and late pregnancy complications, such as preeclampsia and preterm labor. Recent clinical and experimental observations suggest that the pathophysiology of pregnancy failure in patients with APS may involve inflammation at the maternal-fetal interface and disruption of normal trophoblast function and survival, rather than a pro-thrombotic event. While treatment with heparin and aspirin from early pregnancy has been shown to significantly increase the live birth rate in recurrent ...
Source: Thrombosis Research - October 20, 2009 Category: Hematology Authors: Vikki M. Abrahams Tags: Reviews Source Type: journals

Plasma gelsolin facilitates interaction between beta(2) glycoprotein I and alpha5beta1 integrin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we identified plasma gelsolin as a protein associated with beta(2)GPI by using immunoaffinity chromatography and mass spectrometric analysis. An in vivo binding assay showed that endogenous beta(2)GPI interacts with plasma gelsolin, which binds to integrin alpha5beta1 through fibronectin. The tethering of beta(2)GPI to monoclonal anti-beta(2)GPI autoantibody on the cell surface was enhanced in the presence of plasma gelsolin. Immunoblot analysis demonstrated that p38 MAPK protein was phosphorylated by monoclonal anti-beta(2)GPI antibody treatment, and its phosphorylation was attenuated in the presence of ant...
Source: J Cell Mol Med - October 15, 2009 Category: Molecular Biology Authors: Bohgaki M, Matsumoto M, Atsumi T, Kondo T, Yasuda S, Horita T, Nakayama KI, Okumura F, Hatakeyama S, Koike T Tags: J Cell Mol Med Source Type: journals

Lupoid sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Lupoid sclerosis (LS) is a controversial entity, comprising features of both systemic lupus erythematosus and multiple sclerosis. Diagnostic criteria are a matter of debate, as well as the role of antinuclear and antiphospholipid antibodies. In this review, clinical and laboratory findings of LS available on Pubmed up to date are discussed. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00296-009-1175-1Authors Briele Keiserman, Sao Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul Department of Rheumatology Av. Ipiranga 6690/220 90610-000 Porto Alegre BrazilLuiz Fernand...
Source: Rheumatology International - October 13, 2009 Category: Rheumatology Tags: Rheumatology International Source Type: journals

[Reflection and Reaction] Antiphospholipid antibodies: pinning risk on a moving targetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since one of the earliest descriptions of thrombosis associated with antiphospholipid antibodies, researchers have sought to characterise this syndrome of arterial and venous thrombotic manifestations, including miscarriage, combined with moving serological targets—the expanding array of circulating antiphospholipid antibodies (aPL). Urbanus and colleagues address several crucial questions in their multicentre, population-based, case–control investigation of aPL and the risk of myocardial infarction and ischaemic stroke in young women. The study also assessed the synergistic interaction between lupus anticoagulant and ...
Source: Lancet Neurology - October 11, 2009 Category: Neurology Authors: Kathryn Kirchoff-Torres, Steven R Levine Tags: Reflection and Reaction Source Type: journals

[Articles] Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arterial thrombosis is a major clinical manifestation of the antiphospholipid syndrome, which is an autoimmune disease found mostly in young women. Although the presence of circulating antiphospholipid antibodies in individuals who have a thrombotic event is a prerequisite for the diagnosis of the antiphospholipid syndrome, the risk of arterial thrombosis associated with antiphospholipid antibodies in the general population is unclear. (Source: Lancet Neurology)
Source: Lancet Neurology - October 11, 2009 Category: Neurology Authors: Rolf T Urbanus, Bob Siegerink, Mark Roest, Frits R Rosendaal, Philip G de Groot, Ale Algra Tags: Articles Source Type: journals

Right atrium myxoma coexisting with antiphospholipid syndrome: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the unusual findings and diagnostic challenges combined with a review of the literature. (Source: BioMed Central)
Source: BioMed Central - October 10, 2009 Category: Journals (General) Authors: Christos PliakosEleni AlexiadouSymeon MetallidisTheodossis PapavramidisStergios KapoulasKonstantinos SapalidisPavlos Nikolaidis Source Type: journals

Factors influencing polyautoimmunity in systemic lupus erythematosus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Polyautoimmunity is frequent in SLE, and it is influenced by clinical and immunological features. These findings support that clinically different autoimmune phenotypes might share common susceptibility variants. PMID: 19819350 [PubMed - as supplied by publisher] (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - October 7, 2009 Category: Allergy & Immunology Authors: Rojas-Villarraga A, Toro CE, Espinosa G, Rodríguez-Velosa Y, Duarte-Rey C, Mantilla RD, Iglesias-Gamarra A, Cervera R, Anaya JM Tags: Autoimmun Rev Source Type: journals

Cerebral venous thrombosis with dural arteriovenous fistulas and antiphospholipid syndrome: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0166-zAuthors Yasuo Miki, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanMasahiko Tomiyama, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanAkira Arai, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanTamaki Kimura, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanChieko Suzuki, Aomori Prefectural Central Hospital Department of Neurology Hig...
Source: Neurological Sciences - October 6, 2009 Category: Neurology Tags: Neurological Sciences Source Type: journals

How Can We Lower Risk for Clot in Patients With Antiphospholipid Antibodies?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Other factors may be associated with clotting that can be altered to lower patients' risk. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 5, 2009 Category: Consumer Health News Tags: Rheumatology Source Type: news

Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antiphospholipid (aPL) antibodies recognize receptor-bound β2 glycoprotein I (β2GPI) on target cells, and induce an intracellular signaling and a procoagulant/proinflammatory phenotype that leads to thrombosis. Evidence indicates that annexin A2 (A2), a receptor for tissue plasminogen activator and plasminogen, binds β2GPI on target cells. However, whether A2 mediates pathogenic effects of aPL antibodies in vivo is unknown. In this work, we studied the effects of human aPL antibodies in A2-deficient (A2–/–) mice. A2–/– and A2+/+ mice were injected with immunoglobulin G (IgG) isolated ...
Source: Blood - October 1, 2009 Category: Hematology Authors: Romay-Penabad, Z., Montiel-Manzano, M. G., Shilagard, T., Papalardo, E., Vargas, G., Deora, A. B., Wang, M., Jacovina, A. T., Garcia-Latorre, E., Reyes-Maldonado, E., Hajjar, K. A., Pierangeli, S. S. Tags: Thrombosis and Hemostasis Source Type: journals

Stillbirth Classification-Developing an International Consensus for Research: Executive Summary of a National Institute of Child Health and Human Development Workshop.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stillbirth is a major obstetric complication, with 3.2 million stillbirths worldwide and 26,000 stillbirths in the United States every year. The Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop from October 22-24, 2007, to review the pathophysiology of conditions underlying stillbirth to define causes of death. The optimal classification system would identify the pathophysiologic entity initiating the chain of events that irreversibly led to death. Because the integrity of the classification is based on available pathologic, clinical, and diagnostic data, experts emphasize...
Source: Obstetrics and Gynecology - October 1, 2009 Category: OBGYN Authors: Reddy UM, Goldenberg R, Silver R, Smith GC, Pauli RM, Wapner RJ, Gardosi J, Pinar H, Grafe M, Kupferminc M, Hulthén Varli I, Erwich JJ, Fretts RC, Willinger M Tags: Obstet Gynecol Source Type: journals

The Cardiac Manifestations of Antiphospholipid Syndrome and Their Echocardiographic RecognitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antiphospholipid syndrome is an autoimmune disorder characterized by the presence of antiphospholipid antibodies, hypercoagulability, vascular thrombosis, and recurrent fetal loss. Cardiac involvement occurs frequently. Leaflet thickening and vegetations are detected quite often echocardiographically, but hemodynamically significant stenotic and/or regurgitant valvular disease is uncommon. Antiphospholipid syndrome can also cause left and right ventricular systolic and diastolic dysfunction as well as pulmonary hypertension. Other findings include spontaneous echo contrast and in situ mural thrombosis. In this review, the ...
Source: Journal of the American Society of Echocardiography - September 30, 2009 Category: Cardiology Authors: Jeffrey J. Silbiger Tags: State of the Art Review Articles Source Type: journals

CME Test for The Cardiac Manifestations of Antiphospholipid Syndrome and Their Echocardiographic RecognitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Society of Echocardiography)
Source: Journal of the American Society of Echocardiography - September 30, 2009 Category: Cardiology Tags: Continuing Medical Education Source Type: journals

Autoimmune Condition, Especially Combined With Smoking And Oral Contraceptive Use, Massively Increases Risk Of Stroke And Heart Attack In Young WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The autoimmune condition antiphospholipid syndrome mainly affects young women. An Article published Online First and in the November edition of The Lancet Neurology shows that women with a particular subtype of antibody called lupus anticoagulant (LA) have a more than 40-fold increased risk of stroke and 5-fold increased risk of heart attack compared with the general population (of young women). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 29, 2009 Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news

Presence of low titre of antiphospholipid antibodies in cancer patients: a prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a high prevalence of low-titre aPL was found in cancer patients at diagnosis, but no statistical difference in thrombosis-free survival or in overall survival was observed between aPL positive and aPL negative patients. Content Type Journal ArticleCategory IM - OriginalDOI 10.1007/s11739-009-0316-6Authors Mario Bazzan, CMID, Centro Multidisciplinare di Ricerche di Immunopatologia e Documentazione su Malattie Rare, Struttura Complessa a Direzione Universitaria di Immunologia Clinica, Giovanni Bosco Hospital P.zza Donatori di Sangue 3 10154 Turin ItalyBarbara Montaruli, Laboratory Analysis and Oncology ...
Source: Internal and Emergency Medicine - September 29, 2009 Category: Emergency Medicine Tags: Internal and Emergency Medicine Source Type: journals

Young women with circulating antiphospholipid antibodies have increased risk of MI and strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Neurology Area: News Analysis of data from a large case-control study indicates that women who have some sub-types of circulating antiphospholipid antibodies are at significantly increased risk of myocardial infarction (MI) and stroke, especially those taking combined oral contraceptives (COC) and smokers. The antiphospholipid syndrome is an autoimmune disease found mostly in young women, and is associated with an increased risk of arterial thrombosis. However, the risk of arterial thrombosis associated with antiphospholipid antibodies in the general population is not clear: RATIO (Risk of Arteri...
Source: NeLM - News - September 28, 2009 Category: Drugs & Pharmacology Source Type: organizations

Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To test the hypothesis, utilizing 2 experimental mouse models, that plasmin is an important autoantigen that drives the production of certain IgG anticardiolipin (aCL) antibodies in patients with the antiphospholipid syndrome.BALB/cJ and MRL/MpJ mice were immunized with Freund's complete adjuvant in the presence or absence of human plasmin. The mouse sera were analyzed for production of IgG antiplasmin, IgG aCL, and IgG anti-[beta]2-glycoprotein I (anti-[beta]2GPI) antibodies. IgG monoclonal antibodies (mAb) were generated from the plasmin-immunized MRL/MpJ mice with high titers of aCL, and these 10 mAb were studied for th...
Source: Arthritis and Rheumatism - September 28, 2009 Category: Rheumatology Authors: Kaleo Ede, Kwan-Ki Hwang, Chen-Ching Wu, Meifang Wu, Yao-Hsu Yang, Wei-Shiang Lin, Daniel Chien, Pei-Chih Chen, Betty P. Tsao, Deborah K. McCurdy, Pojen P. Chen Tags: antiphospholipid Syndrome Source Type: journals

Lupus anticoagulant ‘a major risk factor for arterial thrombosis’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with a certain form of the autoimmune condition antiphospholipid syndrome face a more than 40-fold increased risk for stroke and a five-fold increased risk fold myocardial infarction compared with the general population, study findings show. (Source: MedWire News - Stroke)
Source: MedWire News - Stroke - September 28, 2009 Category: Neurology Source Type: news

Lupus anticoagulant ‘a major risk factor for arterial thrombosis’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with a certain form of the autoimmune condition antiphospholipid syndrome face a more than 40-fold increased risk for stroke and a five-fold increased risk fold myocardial infarction compared with the general population, study findings show. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - September 28, 2009 Category: Cardiology Source Type: news

Smoking, Oral Contraceptive Use Linked to Increased Cardiovascular Risks in Women with Antiphospholipid SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 27, 2009 Category: Primary Care Tags: Medical News Source Type: info

Newer antiphospholipid antibodies predict adverse outcomes in patients with acute coronary syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antiphospholipid antibodies (aPLs) have been implicated in atherogenesis. We studied 344 patients with acute coronary syndromes; approximately 40% were aPL+ in 1 or more tests and 60% aPL-. In 215 patients, coronary artery disease (CAD) was angiographically documented, with 43.7% positive for aPL vs 34.9% of patients without CAD positive for aPLs. Anti-beta(2)-glycoprotein I (beta2GPI; 54%) and anti-oxidized low-density lipoprotein (oxLDL)/beta2GPI (48%) were most frequent, accounting for 87% of all aPL+ CAD cases. aPLs correlated with severity of CAD (P = .012). Adverse events occurred in 16.7% of patients with CAD, m...
Source: American Journal of Clinical Pathology - September 21, 2009 Category: Pathology Authors: Greco TP, Conti-Kelly AM, Greco T, Doyle R, Matsuura E, Anthony JR, Lopez LR Tags: Am J Clin Pathol Source Type: journals

Isolated elevation of IgA anti-{beta}2glycoprotein I antibodies with manifestations of antiphospholipid syndrome: a case series of five patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report four cases of exclusive IgA anti-beta(2)GPI antibody sero-positivity with concomitant clinical manifestations associated with APS. Four of the five patients were LA negative. 1) Thirty-eight-year-old African-American female with SLE presented with resolving digital ulcers. Serum IgA anti-beta(2)GPI antibody titres were 118.5 SAU (normal range: 0-20 SAU). 2) Twenty-seven-year-old African-American woman with SLE was evaluated for recent onset of severe headaches, unresponsive to analgesics and anti-migraine medications. MRI of the brain revealed hyper-intensities in the white matter in the frontal lobes. Serum IgA ...
Source: Lupus - September 19, 2009 Category: Rheumatology Authors: Kumar S, Papalardo E, Sunkureddi P, Najam S, González E, Pierangeli S Tags: Lupus Source Type: journals

Digital vasculitis in systemic lupus erythematosus: a minor manifestation of disease activity?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, DV in patients with SLE identifies a subgroup of a mild disease. The high 'weighted' index attributed to this alteration in the SLEDAI score should therefore be revised. PMID: 19762400 [PubMed - in process] (Source: Lupus)
Source: Lupus - September 19, 2009 Category: Rheumatology Authors: Gomes C, Carvalho J, Borba E, Borges C, Vendramini M, Bueno C, Costa L, Bonfá E Tags: Lupus Source Type: journals

Catastrophic antiphospholipid syndrome in a patient with Down syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with Down syndrome, under treatment with carbamazepine, levopromazine and clonazepam. After urinary infection he developed glans necrosis requiring excision of prepuce. Six hours post surgery he presented right-hand ischemia followed by arterial and venous thrombosis of the right thoracic extremity. Later, he progressed to a compartment syndrome and presented ischemia of toes. All the clinical manifestations developed over a week. Anticardiolipin (aCL) antibodies, lupus anticoagulant and perinuclear antineutrophil antibodies were positive. Anticoagulant and immunosuppressive treatment were initiated. Ow...
Source: Lupus - September 19, 2009 Category: Rheumatology Authors: Medina G, Calleja C, Morán M, Vera-Lastra O, Jara LJ Tags: Lupus Source Type: journals

Antithyroid antibodies in antiphospholipid syndrome: prevalence and clinical associations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present novel associations between thyroid autoimmunity and ischemic CNS clinical manifestations in the setting of APS. PMID: 19762385 [PubMed - in process] (Source: Lupus)
Source: Lupus - September 19, 2009 Category: Rheumatology Authors: Mavragani C, Danielides S, Zintzaras E, Vlachoyiannopoulos P, Moutsopoulos H Tags: Lupus Source Type: journals

The Rationale for Comparative Studies of Accelerated Atherosclerosis in Rheumatic Diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The inflammatory pathogenesis of atherosclerosis is now well-established, owing to in vitro and in vivo studies and the application of high sensitivity assays for C-reactive protein (CRP) in the general population and specific groups at risk for cardiovascular disease (CVD). In view of the complexity of inflammation-induced atherosclerosis, the rationale for comparative studies of atherogenesis in rheumatic diseases with diverse inflammatory pathogenesis seems obvious; they are human in vivo models to study inflammatory mechanisms involved in atherosclerosis and the impact of treatment. Factors implicated in atherogene...
Source: Atherosclerosis - September 18, 2009 Category: Cardiology Authors: Gasparyan AY, Stavropoulos-Kalinoglou A, Mikhailidis DP, Toms TE, Douglas KM, Kitas GD Tags: Curr Vasc Pharmacol Source Type: journals

Antiphospholipid syndrome may be associated with dysfunctional HDLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women with antiphospholipid syndrome have lower paraoxonase activity and greater functional and structural arterial abnormalities than healthy controls, report researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - September 18, 2009 Category: Lipidology Source Type: news

PRELIMINARY COMMUNICATION: Vascular Abnormalities, Paraoxonase Activity, and Dysfunctional HDL in Primary Antiphospholipid SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Compared with controls, women with aPL had greater functional and structural arterial abnormalities, which were associated with lower activity of paraoxonase. In patients with aPL, HDL reduced nitric oxide bioavailability and had impaired anti-inflammatory and antioxidant properties. (Source: JAMA)
Source: JAMA - September 14, 2009 Category: Journals (General) Authors: Charakida, M., Besler, C., Batuca, J. R., Sangle, S., Marques, S., Sousa, M., Wang, G., Tousoulis, D., Delgado Alves, J., Loukogeorgakis, S. P., Mackworth-Young, C., D'Cruz, D., Luscher, T., Landmesser, U., Deanfield, J. E. Tags: Nutritional and Metabolic Disorders, Lipids and Lipid Disorders, Cardiovascular System, Rheumatology, Rheumatology, Other, Women's Health, Women's Health, Other, Cardiovascular Disease/ Myocardial Infarction, Immunology, Immunologic Disorders Preliminar Source Type: journals

Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Presumed underlying etiologies with POA follow a similar distribution pattern as reported for POF. POA and POF may, therefore, represent a continuum in phenotypical expression of different etiologies of premature ovarian senescence. Like POF, POA should be considered reason to investigate underlying etiologies. (Source: Human Reproduction)
Source: Human Reproduction - September 13, 2009 Category: Reproduction Medicine Authors: Gleicher, N., Weghofer, A., Oktay, K., Barad, D. Tags: OPINION Source Type: journals

Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine-prothrombin complex: Identical or distinct diagnostic tools for antiphospholipid syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our data shows lack of association between aPS/PT antibodies and LA in APS patients with recurrent pregnancy loss. In the evaluation of these patients, there may be redundancy in testing all three markers as the aPT and aPS assays formed part of the aPS/PT antibody repertoire. PMID: 19751711 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - September 10, 2009 Category: Chemistry Authors: Jaskowski TD, Wilson A, Hill HR, Branch WD, Tebo AE Tags: Clin Chim Acta Source Type: journals