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5273 records returned

Novel de novo Mutation in the KCNJ2 Gene in a Patient With Andersen-Tawil SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Andersen-Tawil syndrome is a rare autosomal-dominant disease characterized by episodic muscle weakness, cardiac arrhythmias, and dysmorphic features. Mutations in the KCNJ2 gene (which encodes an inward-rectifying potassium channel protein, Kir2.1) have been reported to be responsible for this disorder. Reported here is a novel de novo mutation in the KCNJ2 gene in a patient with Andersen-Tawil syndrome. This mutation predicts the substitution of alanine for glycine at position 146 (Gly146Ala, c.437G > C) of Kir2.1 and is located at the extracellular pore loop region that serves as a principal ion-selective filter. The pat...
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: June-Bum Kim, Ki-Wha Chung Tags: Case Reports Source Type: journals

Videothoracoscopy for isolated atrial fibrillation ablation through bipolar radiofrequencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The video-assisted surgery for the treatment of atrial fibrillation is reproducible and safe. There is a heart failure symptom evolution improvement after the surgery. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Peri-operative evaluation by holter in elderly patients submitted to prostatectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Ambulatory monitoring is not regarded as an appropriate procedure for the screening of myocardial ischemia, due to the characteristics and technical limitations of the method, especially in populations with a low prevalence of coronary disease. In this cross-sectional and observational study, we concluded that the Holter recordings provided additional information which could not be obtained by conventional electrocardiogram. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Postpartum torsades de pointes and long QT syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reports the case of a puerperal patient admitted with diagnosis of urinary tract infection and heart failure. This condition evolved with torsades de pointes ventricular arrhythmias, then, hypokalemia, and use of Ciprofloxacin. Ventricular arrhythmias did not present any improvement after potassium and magnesium replacement, but after implantation of temporary pacemaker, this condition showed signs of improvement. The patient was discharged with QTc at 490 ms, taking Propranolol. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Sleep-Related Breathing Pauses May Trigger Nocturnal ArrhythmiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risk of nocturnal arrhythmias is markedly increased shortly after the occurrence of sleep-related breathing pauses in patients with sleep-disordered breathing, according to study findings in the Journal of the American College of Cardiology for November. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Genotype–Phenotype Relationship in the Long QT Syndrome: Brimming With Knowledge but Thirsting for a Therapeutic Solution⁎Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since it was first reported 50 years ago, the long QT syndrome (LQTS) is now recognized as a genetic disease caused by mutations of ion channel genes encoding a cardiac channel essential for the control of ventricular repolarization (). The LQTS is not only the most common and extensively researched genetic cardiac arrhythmia (), it has also attracted premier scientists and scholars in single-cell electrophysiology and molecular genetics. In turn, they have produced seminal discoveries that shaped our understanding of the syndrome. The mutated genes in LQTS patients cause delayed repolarization and, in turn, prolong the QT...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Koonlawee Nademanee Tags: Editorial Comment Source Type: journals

A Comparison of Atrial Arrhythmias After Heart or Double-Lung Transplantation at a Single Center: Insights Into the Mechanism of Post-Operative Atrial FibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In heart transplant recipients, AF is uncommon and occurs in the setting of myocardial dysfunction and graft rejection. In contrast, AF is more common after lung transplantation despite the absence of graft rejection and cardiac dysfunction. Pulmonary vein isolation alone cannot explain the discrepancy in AF incidence between heart transplant recipients and double-lung transplant recipients. Cardiac autonomic denervation may have a protective effect for heart transplant patients in the post-operative setting. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: José Dizon, Kimberly Chen, Matthew Bacchetta, Michael Argenziano, Donna Mancini, Angelo Biviano, Joshua Sonett, Hasan Garan Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Acute abdomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 19, 2009 Category: Journals (General) Tags: Neurogastroenterology, Pancreas and biliary tract, Infectious diseases, Small intestine, Immunology (including allergy), Drugs: cardiovascular system, Pain (neurology), Stroke, Inflammation, Trauma, arrhythmias, Injury ENDGAMES Source Type: journals

Lidocaine Hydrochloride Injection BP 1% w/v/, 2% w/v - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.2 (Posology and method of administration) Addition of children's age - "Single doses of Lidocaine (for anaesthesia other than spinal) should not exceed 4.5 mg/kg (or 200 mg) in adults or children 12 - 18 years of age." A further addition of: "Lidocaine by local infiltration for children under the age of 12 years should not exceed 3mg/kg, repeated not more often than every 4 hours." Section 4.3 (Contraindications) In ventricular arrhythmia: Sino-atrial disorders, all g...
Source: NeLM - Anaesthesia - November 19, 2009 Category: Anesthesiology Source Type: organizations

Prognostic value of coronary revascularisation-related myocardial injury: a cardiac magnetic resonance imaging studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Myocardial injury during PCI or CABG, identified by DE-CMR, adversely affects clinical outcome. This suggests the benefits from revascularisation could partially be offset by new myocardial injury caused by the intervention itself. (Source: Heart)
Source: Heart - November 18, 2009 Category: Cardiology Authors: Rahimi, K, Banning, A P, Cheng, A S H, Pegg, T J, Karamitsos, T D, Channon, K M, Darby, S, Taggart, D P, Neubauer, S, Selvanayagam, J B Tags: Editor's choice, Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Percutaneous intervention, Clinical diagnostic tests Original articles Source Type: journals

Congenital Left Atrial Appendage Aneurysm: A Case Report and Brief Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 28-year-old woman with congenital aneurysm of the left atrial appendage was successfully treated by aneurysmectomy and is reported for its rarity. The exact diagnosis is relatively easy to make by contrast echocardiography, magnetic resonance imaging, and/or computerised tomographic angiography, provided the possibility is entertained. Because of supraventricular arrhythmias and systemic thromboembolism, surgical resection was deemed the best curative option to avoid further episodes and recurrence. Published reports detailing the diagnostic evaluation and surgical management for congenital left atrial appendage aneurysm...
Source: Heart, Lung & Circulation - November 18, 2009 Category: Cardiology Authors: Ujjwal K. Chowdhury, Sandeep Seth, Raghu Govindappa, Priya Jagia, Poonam Malhotra Tags: Case Reports Source Type: journals

Ventricular fibrillation: A life-threatening, but treatable heart arrhythmiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ventricular fibrillation — Comprehensive overview covers the causes and treatments of this life-threatening heart arrhythmia. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - November 18, 2009 Category: Consumer Health News Source Type: news

Determining Arrhythmia Mechanism: Still Critical or Now Obsolete?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - November 18, 2009 Category: Cardiology Authors: FRANK C. CHEN, SAMUEL J. ASIRVATHAM Source Type: journals

Does This Patient With Palpitations Have a Cardiac Arrhythmia? [The Rational Clinical Examination]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions While the presence of a regular rapid-pounding sensation in the neck or visible neck pulsations associated with palpitations makes the diagnosis of atrioventricular nodal reentry tachycardia likely, the reviewed studies suggest that the clinical examination is not sufficiently accurate to exclude clinically significant arrhythmias in most patients. Thus, prolonged electrocardiographic monitoring with demonstration of symptom-rhythm correlation is required to make the diagnosis of a cardiac arrhythmia for most patients with recurrent palpitations. (Source: JAMA)
Source: JAMA - November 17, 2009 Category: Journals (General) Authors: Thavendiranathan, P., Bagai, A., Khoo, C., Dorian, P., Choudhry, N. K. Tags: Physical Examination, Cardiovascular System, Radiologic Imaging, Diagnosis, Echocardiography, arrhythmias, Cardiac Diagnostic Tests The Rational Clinical Examination Source Type: journals

Monitoring of atrial fibrillation burden after surgical ablation: relevancy of end-point criteria after radiofrequency ablation treatment of patients with lone atrial fibrillation [Institutional report - Arrhythmia]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Studies have shown that continuous rhythm monitoring enables the detection of significantly more atrial fibrillation (AF) episodes than routine follow-up of patients, i.e. based on perception of symptoms or on 24–48 h Holter monitoring. The positive outcome of radiofrequency ablation (RFA) may be easily overestimated, especially in patients with paroxysmal AF. Thirty-three consecutive patients, aged 59.4±8.9 years (range 38–75 years) participated in this study. All patients had documented AF episodes with an AF duration of 9.4±7.1 years (range 1.5–25 years). A new monitor...
Source: Interactive CardioVascular and Thoracic Surgery - November 17, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Beukema, R., Beukema, W. P., Sie, H. T., Misier, A. R., Delnoy, P. P., Elvan, A. Tags: Institutional report - arrhythmia Source Type: journals

A Prospective Randomized Multicenter Comparison on Health-Related Quality of Life: The Value of Add-on Arrhythmia Surgery in Patients with Paroxysmal, Permanent or Persistent Atrial Fibrillation Undergoing Valvular and/or Coronary Bypass SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Health-related quality of life in patients with paroxysmal, permanent and persistent atrial fibrillation improves after cardiac surgery regardless of giving add-on surgery or not, but this improvement is presumably more affected by treating the underlying heart disease than by restoring sinus rhythm. (J Cardiovasc Electrophysiol, Vol. pp. 1[ndash]10) (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - November 17, 2009 Category: Cardiology Authors: H. N. A. M. VAN BREUGEL, F. H. M. NIEMAN, R. E. ACCORD, G. A. P. G. VAN MASTRIGT, J. F. M. A. NIJS, J. L. SEVERENS, R. VRAKKING, J. G. MAESSEN Source Type: journals

MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that the β-adrenergic pathway can stimulate expression of arrhythmogenic miR-1, contributing to ischaemic arrhythmogenesis, and β-blockers produce their beneficial effects partially by down-regulating miR-1, which might be a novel strategy for ischaemic cardioprotection. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Lu, Y., Zhang, Y., Shan, H., Pan, Z., Li, X., Li, B., Xu, C., Zhang, B., Zhang, F., Dong, D., Song, W., Qiao, G., Yang, B. Tags: ORIGINAL ARTICLES Source Type: journals

Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Loss of the regulatory domain of Cx43 leads to an increase in infarct size and increased susceptibility to arrhythmias following acute coronary occlusion. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Maass, K., Chase, S. E., Lin, X., Delmar, M. Tags: ORIGINAL ARTICLES Source Type: journals

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Redox modulation of RyRs promotes generation of Ca2+ alternans by enhancing the steepness of the Ca2+ release–load relationship and thereby providing a substrate for post-MI arrhythmias. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Belevych, A. E., Terentyev, D., Viatchenko-Karpinski, S., Terentyeva, R., Sridhar, A., Nishijima, Y., Wilson, L. D., Cardounel, A. J., Laurita, K. R., Carnes, C. A., Billman, G. E., Gyorke, S. Tags: ORIGINAL ARTICLES Source Type: journals

Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Cardiac overexpression of a Ca2+-channel β2a-subunit alone is sufficient to induce Ca2+-channel properties characteristic of chronic human heart failure. β2a-overexpression by itself did not induce cardiac hypertrophy or contractile dysfunction, but aggravated the development of arrhythmia and fibrosis in Cav1.2-transgenic mice. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Beetz, N., Hein, L., Meszaros, J., Gilsbach, R., Barreto, F., Meissner, M., Hoppe, U. C., Schwartz, A., Herzig, S., Matthes, J. Tags: ORIGINAL ARTICLES Source Type: journals

FDA recalls dietary supplement Pai You Guo due to presence of undeclared drug ingredientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: FDA Area: News GMP Herbal Products and the FDA have notified consumers and healthcare professionals in the US of a recall of Pai You Guo, a weight loss dietary supplement, due to the presence of undeclared drug ingredients (sibutramine and phenolphthalein). The FDA advises that these products pose a threat to consumers because sibutramine is known to substantially increase blood pressure and/or pulse rate in some patients, and may present a significant risk for patients with a history of coronary artery disease, congestive heart failure, arrhythmias or stroke. The Agency has not a...
Source: NeLM - News - November 16, 2009 Category: Drugs & Pharmacology Source Type: organizations

Ca(V)1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations of human Ca(V)1.2 channel gene were identified only recently. The gain-of-function mutations were found at two mutually exclusive exons in patients with Timothy syndrome (TS). These patients exhibit prolonged QT interval and lethal cardiac arrhythmias. In contrast, the loss-of-function mutations of Ca(V)1.2 channel in patients with Brugada syndrome produce short QT interval that could result in sudden cardiac death. TS patients also suffer from multi-organ dysfunction that includes neurological disorder such as autism and mental retardation reflecting the wide tissue distribution of Ca(V)1.2 channel. Mutation...
Source: Pflugers Archiv : European Journal of Physiology - November 15, 2009 Category: Physiology Authors: Liao P, Soong TW Tags: Pflugers Arch Source Type: journals

Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Together these data demonstrate that autologous MSCs can be safely delivered in an adult heart failure model, producing substantial structural and functional reverse remodelling. These findings demonstrate the safety and efficacy of autologous MSC therapy and support clinical trials of MSC therapy in patients with chronic ischaemic cardiomyopathy. (Source: European Heart Journal)
Source: European Heart Journal - November 14, 2009 Category: Cardiology Authors: Schuleri, K. H., Feigenbaum, G. S., Centola, M., Weiss, E. S., Zimmet, J. M., Turney, J., Kellner, J., Zviman, M. M., Hatzistergos, K. E., Detrick, B., Conte, J. V., McNiece, I., Steenbergen, C., Lardo, A. C., Hare, J. M. Tags: Coronary heart disease Source Type: journals

A simplified biventricular defibrillator with fixed long detection intervals reduces implantable cardioverter defibrillator (ICD) interventions and heart failure hospitalizations in patients with non-ischaemic cardiomyopathy implanted for primary prevention: the RELEVANT [Role of long dEtection window programming in patients with LEft VentriculAr dysfunction, Non-ischemic eTiology in primary prevention treated with a biventricular ICD] studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A simplified CRT-D device with fixed long detection reduced overall ICD therapy burden and HF hospitalizations without entailing any additional adverse events in primary prevention non-ischaemic HF patients. (Source: European Heart Journal)
Source: European Heart Journal - November 14, 2009 Category: Cardiology Authors: Gasparini, M., Menozzi, C., Proclemer, A., Landolina, M., Iacopino, S., Carboni, A., Lombardo, E., Regoli, F., Biffi, M., Burrone, V., Denaro, A., Boriani, G. Tags: arrhythmia/electrophysiology Source Type: journals

Beat-to-Beat QT Interval Dynamics and Variability in Familial DysautonomiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, most QT dynamics parameters in patients with FD are similar to that of normal controls. Nevertheless, FD patients have significantly higher QTVN, which might indicate higher risk for ventricular arrhythmias. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00246-009-9575-2Authors Udi Nussinovitch, Tel Aviv University Department of Internal Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel and Sackler Faculty of Medicine Tel Aviv IsraelUriel Katz, Tel Aviv University Department of Pediatric Cardiology, Chaim Sheba Medical Center, Tel Hashomer, Israel and Sackler Faculty of Me...
Source: Pediatric Cardiology - November 14, 2009 Category: Cardiology Tags: Pediatric Cardiology Source Type: journals

Heart Rate Variability in Children with Exercise-Induced Idiopathic Ventricular ArrhythmiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Ventricular arrhythmias (VAs) are common pediatric rhythm disorders requiring comprehensive laboratory evaluation. Although usually idiopathic, implying a benign character and favorable prognosis, the initial clinical approach is still not established in all cases. Considering their prognostic significance, exercise-induced (precipitated or aggravated) VAs usually require additional diagnostics, treatment, and follow-up. A number of reports have presented experimental and clinical evidence that increased sympathetic activity can initiate, or at least facilitate, VAs. Recent data highlight the relati...
Source: Pediatric Cardiology - November 14, 2009 Category: Cardiology Tags: Pediatric Cardiology Source Type: journals

Catheter ablation of supraventricular arrhythmias and atrial fibrillation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Supraventricular arrhythmias are relatively common, often persistent, and rarely life-threatening cardiac rhythm disturbances that arise from the sinus node, atrial tissue, or junctional sites between the atria and ventricles. The term "supraventricular arrhythmia" most often is used to refer to supraventricular tachycardias and atrial flutter. The term "supraventricular tachycardia" commonly refers to atrial tachycardia, atrioventricular nodal reentrant tachycardia, and atrioventricular reciprocating tachycardia, an entity that includes Wolff-Parkinson-White syndrome. Atrial fibrillation is a distinct entity classifie...
Source: American Family Physician - November 13, 2009 Category: Primary Care Authors: Shapira AR Tags: Am Fam Physician Source Type: journals

A Single Exposure to Particulate or Gaseous Air Pollution Increases the Risk of Aconitine-Induced Cardiac Arrhythmia in Hypertensive RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a single exposure to air pollution may increase the sensitivity of cardiac electrical conduction to disruption. Moreover, there seem to be host factors (e.g., cardiovascular disease) that increase vulnerability to triggered arrhythmias regardless of the pollutant or its concentration. (Source: Toxicological Sciences)
Source: Toxicological Sciences - November 13, 2009 Category: Toxicology Authors: Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Costa, D. L., Farraj, A. K. Tags: SYSTEMS TOXICOLOGY Source Type: journals

Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licoriceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia. He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy. After taking him off all drugs and administering spironolactone supplemented with potassium, his low serum potassium level was ameliorated. Therefore, although garenoxacin reportedly causes fewer advers...
Source: Clinical and Experimental Nephrology - November 13, 2009 Category: Urology & Nephrology Tags: Clinical and Experimental Nephrology Source Type: journals

Integrated treatment of cardiovascular common pathologies with conventional pharmacological therapy integrated with a typical remedy of anthroposophic medicine, Cardiodoron (Onopordon/Primula comp)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anthroposophic medicine (AM) in Italy is mostly practiced in private settings: practices, multidisciplinary day-centers and a thermal clinic. In the General Medicine Department of the Istituto Clinico San Siro (ICSS), in Milan, AM has been used since 2000 in an integrated context, as a complementary or alternative treatment to conventional therapies.The department has one ambulance and 10 beds and treats acute, subacute and chronic orthopedic, postoperative, cardiovascular and oncological pathologies. Approximately 250 patients are treated each year. ICSS is a private clinic operating under a convention with the Italian NH...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: E. Mariani, C. Donarini, D. Grampella, T. Guerrerio, G. Landoni, E. Portalupi Source Type: journals

New Center For Cardiac Safety And Innovation Launched By URMCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The University of Rochester Medical Center (URMC) has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety - funded by a $2. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 13, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

New Center For Cardiac Safety And Innovation Launched By URMCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The University of Rochester Medical Center (URMC) has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety - funded by a $2. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 13, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Large People Prone To Enlarged Hearts: Obesity Leading Risk Factor Of Left Atrial Enlargement During AgingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aside from aging itself, obesity appears to be the most powerful predictor of left atrial enlargement, upping one's risk of atrial fibrillation (the most common type of arrhythmia), stroke and death, according to a new article. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 13, 2009 Category: Science Source Type: news

CVN: Heart MinuteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heart Minute: Sleep Apnea and Arrhythmias (Source: Cardiosource)
Source: Cardiosource - November 13, 2009 Category: Cardiology Source Type: organizations

High Resolution Electrical Mapping of Depolarization and Repolarization Alternans in an Ischemic Dog Model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac electrical alternans have been associated with spontaneous ventricular arrhythmias during myocardial ischemia. The study aims were to use a new algorithm to measure depolarization and repolarization alternans from epicardial electrograms in an ischemia model and evaluate which features are predictive of ventricular fibrillation (VF). The left anterior descending coronary artery was occluded in 21 dogs of which six developed spontaneous VF. Four seconds of unipolar epicardial electrograms were recorded before and five minutes after occlusion from an 8x14 electrode plaque placed on the anterior left ventricle. Al...
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 13, 2009 Category: Physiology Authors: Gordon D, Kadish AH, Koolish D, Taneja T, Ulphani J, Goldberger JJ, Ng J Tags: Am J Physiol Heart Circ Physiol Source Type: journals

Adult Congenital Heart Disease: Importance of the Right VentricleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The right ventricle (RV) is of lesser importance in acquired heart disease, but its role is of increasing importance in congenital heart disease. It may function as a subpulmonary ventricle or as a subaortic (systemic) ventricle in transposition complexes. The RV has a remarkable ability to adapt to pressure and volume load, but its size and function are often overlooked. Patients usually develop symptoms only after RV dysfunction has occurred, and in many diverse clinical scenarios, late referral is common. Advanced RV enlargement and dysfunction are responsible for not only impaired functional capacity but also lethal ve...
Source: Journal of the American College of Cardiology - November 12, 2009 Category: Cardiology Authors: Carole A. Warnes Tags: STATE-OF-THE-ART PAPERS Source Type: journals

Percutaneous Access of the Epicardial Space for Mapping Ventricular and Supraventricular Arrhythmias in Patients With and Without Prior Cardiac SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In patients without prior cardiac surgery, percutaneous epicardial access can be obtained in the majority of patients. Prior cardiac surgery precludes access in the most patients and when possible adhesions may limit catheter movement. Repeat access is possible in the majority of patients without the installation of intrapericardial glucocorticoid at the first procedure. (J Cardiovasc Electrophysiol, Vol. pp. 1[ndash]6) (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - November 12, 2009 Category: Cardiology Authors: KURT C. ROBERTS-THOMSON, JENS SEILER, DANIEL STEVEN, KEIICHI INADA, GREGORY F. MICHAUD, ROY M. JOHN, BRUCE A. KOPLAN, LAURENCE M. EPSTEIN, WILLIAM G. STEVENSON, USHA B. TEDROW Source Type: journals

New Technology Increases Odds Of A Cure For Patients With ArrhythmiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physicians with California Pacific Medical Center are among the first in the nation to use a new advanced mapping technology to help treat patients suffering from debilitating and potentially dangerous heart rhythm disorders. The technology, the newly FDA-approved CARTO® 3 Navigation System, uses a three-dimensional mapping system to enable doctors to quickly and accurately maneuver within the complex anatomy of the heart. (Source: Medical Devices News From Medical News Today)
Source: Medical Devices News From Medical News Today - November 11, 2009 Category: Medical Equipment Tags: Heart Disease Source Type: news

New Technology Increases Odds Of A Cure For Patients With ArrhythmiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physicians with California Pacific Medical Center are among the first in the nation to use a new advanced mapping technology to help treat patients suffering from debilitating and potentially dangerous heart rhythm disorders. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Heart Disease Source Type: news

New research center to focus on cardiac safety and innovationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Rochester Medical Center) The University of Rochester Medical Center has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety -- funded by a $2.3 million grant from NIH -- brings together an international network of academic researchers, pharmaceutical and medical device companies, and government regulators. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 11, 2009 Category: Global & Universal Source Type: news

The Death of John Paul Jones and Resurrection as 'Father of the US Navy'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
John Paul Jones, 'father of the US Navy', died under mysterious circumstances on July 18, 1792. Although his remains were resurrected and autopsied 113 years later, the cause of his death has yet to be explained fully. In this detailed review of his clinical history and autopsy findings, we conclude, as have others, that Jones died of kidney failure of undermined etiology. Although 'interstitial nephritis' was diagnosed by the prosectors who performed his autopsy, we believe glomerulopathy (possibly IgA nephropathy) was more likely responsible for his kidney failure and that his death was due to a cardiac arrhythmia or...
Source: American Journal of Nephrology - November 11, 2009 Category: Urology & Nephrology Authors: Weir MR, Bogle LL, Mackowiak PA Tags: Am J Nephrol Source Type: journals

Outcomes in Patients With Prolonged PR Interval or First-Degree Atrioventricular Block [Letters]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JAMA)
Source: JAMA - November 10, 2009 Category: Journals (General) Authors: Oh, J., Won, H. Y., Kang, S.-M. Tags: Pacemakers/ Defibrillators, Cardiovascular System, Prognosis/ Outcomes, arrhythmias, Cardiac Diagnostic Tests, Cardiovascular Intervention Letters Source Type: journals

Outcomes in Patients With Prolonged PR Interval or First-Degree Atrioventricular Block--Reply [Letters]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JAMA)
Source: JAMA - November 10, 2009 Category: Journals (General) Authors: Cheng, S., Wang, T. J. Tags: Pacemakers/ Defibrillators, Cardiovascular System, Prognosis/ Outcomes, arrhythmias, Cardiac Diagnostic Tests, Cardiovascular Intervention Letters Source Type: journals

The Leading Risk Factor Of Left Atrial Enlargement During Aging Is ObesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aside from aging itself, obesity appears to be the most powerful predictor of left atrial enlargement (LAE), upping one's risk of atrial fibrillation (the most common type of arrhythmia), stroke and death, according to findings published in the November 17, 2009, issue of the Journal of the American College of Cardiology. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news

The Leading Risk Factor Of Left Atrial Enlargement During Aging Is ObesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aside from aging itself, obesity appears to be the most powerful predictor of left atrial enlargement (LAE), upping one's risk of atrial fibrillation (the most common type of arrhythmia), stroke and death, according to findings published in the November 17, 2009, issue of the Journal of the American College of Cardiology. (Source: Cardiovascular / Cardiology News From Medical News Today)
Source: Cardiovascular / Cardiology News From Medical News Today - November 10, 2009 Category: Cardiology Tags: Obesity / Weight Loss / Fitness Source Type: news

Atrial fibrillation affects outcome of acute coronary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with acute coronary syndrome and new-onset atrial fibrillation have worse in-hospital outcomes than those without the arrhythmia, Australian researchers report. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 10, 2009 Category: Cardiology Source Type: news

Medtronic Inc. Cardiac Rhythm Disease Managment - Medtronic Virtuoso DR - Class 2 RecallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medtronic Virtuoso DR, D154AWG, Dual Chamber implantable cardioverter defibrillator with atrial and ventricular therapies. Medtronic, Inc., 710 Medtronic Parkway, Minneapolis, MN 55432-5604 USA. This device is indicated to provide ventricular antitachycardia pacing and ventricular defibrillation for automated treatment of life-threatening ventricular arrhythmias in patients with NYHA functional Class II/III heart failure. In addition, the device is indicated for use in the above patients with atrial tachyarrhythmias, or those patients who are at significant risk of developing atrial tachyarrhythmias. (Source: Medical Devic...
Source: Medical Device Recalls since July 07, 2006 - November 10, 2009 Category: Medical Equipment Source Type: organizations

Medtronic Inc. Cardiac Rhythm Disease Managment - Medtronic Virtuoso VR - Class 2 RecallEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medtronic Virtuoso VR, Model D154VWC, Single Chamber implantable cardioverter defibrillator with atrial therapies. Medtronic, Inc., 710 Medtronic Parkway, Minneapolis, MN 55432-5604 USA. This device is indicated to provide ventricular antitachycardia pacing and ventricular defibrillation for automated treatment of life-threatening ventricular arrhythmias in patients with NYHA functional Class II/III heart failure. (Source: Medical Device Recalls since July 07, 2006)
Source: Medical Device Recalls since July 07, 2006 - November 10, 2009 Category: Medical Equipment Source Type: organizations

Transseptal Dispersion of Repolarization and Its Role in the Development of Torsade de Pointes ArrhythmiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data indicate that dispersion of repolarization across the interventricular septum is twice that of the LV free wall, predisposing to development of TdP under long-QT conditions. Our findings suggest that the coronary-perfused ventricular septal preparation may be a sensitive model in which to assess the potential arrhythmogenic effects of drugs and pathophysiological conditions. (J Cardiovasc Electrophysiol, Vol. pp. 1[ndash]7) (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - November 10, 2009 Category: Cardiology Authors: SERGE SICOURI, AARON GLASS, MARCELA FERREIRO, CHARLES ANTZELEVITCH Source Type: journals