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The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Treatment with statins already in early stages of ICA stenosis might delay the progression and even reverse the degree of stenosis. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 16, 2009 Category: Neurology Authors: O. Hegland, M. W. Kurz, P. S. Munk, J. P. Larsen Source Type: journals

American Heart Association Junior Investigator Award for WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sponsored by the Women’s Leadership Committee of the Council on Arteriosclerosis, Thrombosis and Vascular BiologyThe Junior Investigator Award for Women helps recruit and retain women in the field of arteriosclerosis, thrombosis and vascular biology by recognizing excellent research conducted by women.CriteriaThe applicant must: * Be a junior female investigator in training in one or more ATVB fields at the time of application (graduate student or postdoctoral fellow, with no more than five consecutive years as a postdoctoral fellow). * Achieve a rating among the top 5 abstracts, fitting the criteria presented abo...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: American Heart Association Source Type: funding

American Heart Association Kenneth M. Brinkhous Young Investigator Prize in ThrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sponsored by the Council on Arteriosclerosis, Thrombosis and Vascular BiologyThe Kenneth M. Brinkhous Young Investigator Prize in Thrombosis recognizes outstanding endeavors by new investigators in fundamental and applied research in thrombosis including the mechanism, detection, treatment, and prevention of thrombotic disorders.Criteria * Manuscript must be unpublished or published (or accepted for publication) after Jan. 1, 2009. * Individuals with doctoral degrees are eligible from the time of obtaining their terminal degrees to within the first five years of an initial faculty appointment at the time of the award ap...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: American Heart Association Source Type: funding

American Heart Association Irvine H. Page Young Investigator Research AwardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sponsored by the Council on Arteriosclerosis, Thrombosis and Vascular BiologyThe Irvine H. Page Young Investigator Research Award is open to new investigators in arteriosclerosis and vascular biology. The award recognizes investigators in the formative years of their careers who have the potential to become future leaders in cardiovascular research.Criteria * Manuscript must be unpublished or published (or accepted for publication) after Jan. 1, 2009. * Persons with doctoral degrees are eligible from the time of obtaining their terminal degrees to within the first five years of an initial faculty appointment at the time...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: American Heart Association Source Type: funding

Effectiveness and tolerability of the homeopathic treatment Vertigoheel for the treatment of vertigo in hypertensive subjects in general clinical practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Vertigoheel appears to have positive effects on vertigo in hypertensive patients >aged 50 years. Given its good tolerability Vertigoheel could be particularly beneficial for treating vertigo in an elderly population with a diagnosis of hypertension and further concomitant diseases. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: E. Seeger-Schellerhoff, M. Corgiolu Source Type: journals

CAM-orientated therapy for age-related vertigo in cases of suspected arteriosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many elderly patients with comorbid conditions such as hypertension or lipid disorders suffer from vertigo and dizziness, one of the 10 symptoms that are most commonly seen in general medical practice. The prevalence of these symptoms increases with age. Patients reported feeling unsteady, to stagger, or to have tendencies to fall. Overall, these symptoms interfere with patients’ ability of coping with everyday tasks. In up to 80% of patients, no vestibular findings are apparent, meaning that the feeling of vertigo is likely to be related to circulatory problems, orthostatic disorders or psychological causes. Symptomatic...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: Elfi Seeger-Schellerhoff Source Type: journals

Vertigo—The practitioner's viewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dizziness and vertigo (International Classification of Disease-R42) are listed under the top 10 symptoms in an outpatient setting seeking advice by a primary care physician. The lifetime prevalence of dizziness/vertigo is reported to be up to 30% with a female preponderance. The incidence of dizziness and vertigo increases with age. Common findings of comorbidities like hypertension, lipid disorders and others pointing to arteriosclerosis in the elderly are associated with dizziness symptoms; however, a causal relationship is not uniformly given. Therefore the role of concomitant disease for dizziness in the elderly is sti...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: J.-H. Wichert Source Type: journals

Leptin Enhances the Potency of Circulating Angiogenic Cells Via Src Kinase and Integrin {alpha}v{beta}5. Implications for Angiogenesis in Human Obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results point to the ObR-Src kinase-alphavbeta5 cross talk as a distinct novel component of the network of specific interactions between integrins and cytokine receptors in angiogenesis. PMID: 19910644 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Heida NM, Leifheit-Nestler M, Schroeter MR, Müller JP, Cheng IF, Henkel S, Limbourg A, Limbourg FP, Alves F, Quigley JP, Ruggeri ZM, Hasenfuss G, Konstantinides S, Schäfer K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Altered Plasma Fibrin Clot Properties Are Associated With In-Stent Thrombosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: IST patients tend to form dense fibrin clots resistant to lysis, and altered plasma fibrin clot features might contribute to the occurrence of IST. PMID: 19910643 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Undas A, Zalewski J, Krochin M, Siudak Z, Sadowski M, Pregowski J, Dudek D, Janion M, Witkowski A, Zmudka K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Loss of Stearoyl-CoA Desaturase-1 Attenuates Adipocyte Inflammation. Effects of Adipocyte-Derived Oleate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Loss of SCD1 attenuates adipocyte inflammation and its paracrine regulation of inflammation in macrophages and endothelial cells. The reduced oleate level is linked to the inflammation-modulating effects of SCD1 deficiency. PMID: 19910642 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Liu X, Miyazaki M, Flowers MT, Sampath H, Zhao M, Chu K, Paton CM, Joo DS, Ntambi JM Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Obesity Genotype Score and Cardiovascular Risk in Women With Type 2 Diabetes Mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Obesity-predisposing variants may jointly affect CVD risk among women with diabetes. PMID: 19910641 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L Tags: Arterioscler Thromb Vasc Biol Source Type: journals

NADPH Oxidases: Functions and Pathologies in the Vasculature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reactive oxygen species are ubiquitous signaling molecules in biological systems. Four members of the NADPH oxidase (Nox) enzyme family are important sources of reactive oxygen species in the vasculature: Nox1, Nox2, Nox4, and Nox5. Signaling cascades triggered by stresses, hormones, vasoactive agents, and cytokines control the expression and activity of these enzymes and of their regulatory subunits, among which p22phox, p47phox, Noxa1, and p67phox are present in blood vessels. Vascular Nox enzymes are also regulated by Rac, ClC-3, Poldip2, and protein disulfide isomerase. Multiple Nox subtypes, simultaneously present...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Lassègue B, Griendling KK Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Genetic Association and Interaction Analysis of USF1 and APOA5 on Lipid Levels and Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our findings in these unique samples reinforce the roles of APOA5 and USF1 variants on cardiovascular phenotypes and suggest that both genes contribute to lipid levels and aortic atherosclerosis individually and possibly through epistatic effects. PMID: 19910639 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Laurila PP, Naukkarinen J, Kristiansson K, Ripatti S, Kauttu T, Silander K, Salomaa V, Perola M, Karhunen PJ, Barter PJ, Ehnholm C, Peltonen L Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our data show that loss of Tie1 results in lymphatic vascular abnormalities that precede the blood vessel phenotype. These findings indicate that Tie1 is involved in lymphangiogenesis and suggest differential requirements for Tie1 signaling in the 2 vascular compartments. PMID: 19910638 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: D'Amico G, Korhonen E, Waltari M, Saharinen P, Laakkonen P, Alitalo K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Claudin-5 as a Novel Estrogen Target in Vascular Endothelium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We describe claudin-5 as a novel estrogen target in vascular endothelium and show in vivo (brain endothelium) and in vitro (brain and heart endothelium) effects of estrogen on claudin-5 levels. The estrogen-induced increase in junctional protein levels may lead to an improvement in vascular structural integrity and barrier function of vascular endothelium. PMID: 19910637 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Burek M, Arias-Loza PA, Roewer N, Förster CY Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Metabolism of Very-Low-Density Lipoprotein and Low-Density Lipoprotein Containing Apolipoprotein C-III and Not Other Small Apolipoproteins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results suggest that apoCIII strongly inhibits hepatic uptake of VLDL and IDL overriding the opposite influence of apoE when both are present. The presence of apoCIII on dense VLDL is not associated with slow conversion to IDL, a lipoprotein lipase-dependent process; but when on light LDL, apoCIII is associated with enhanced conversion to dense LDL, a process involving hepatic lipase. PMID: 19910636 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Mendivil CO, Zheng C, Furtado J, Lel J, Sacks FM Tags: Arterioscler Thromb Vasc Biol Source Type: journals

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Diet-induced obesity increased CD11c in both AT and blood in mice and humans. CD11c plays an important role in T-cell accumulation and activation in AT, and contributes to insulin resistance associated with obesity. PMID: 19910635 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Wu H, Perrard XD, Wang Q, Perrard JL, Polsani VR, Jones PH, Smith CW, Ballantyne CM Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Human Apolipoprotein A-II Determines Plasma Triglycerides by Regulating Lipoprotein Lipase Activity and High-Density Lipoprotein Proteome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ApoA-II plays a crucial role in triglyceride catabolism by regulating LPL activity, at least in part, through HDL proteome modulation. PMID: 19910634 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Julve J, Escolà-Gil JC, Rotllan N, Fiévet C, Vallez E, de la Torre C, Ribas V, Sloan JH, Blanco-Vaca F Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Hemorphin 7 Reflects Hemoglobin Proteolysis in Abdominal Aortic Aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that circulating H7 peptides may reflect proteolysis of hemoglobin in the aneurysmal intraluminal thrombus and may be used as a biological marker of pathological vascular remodeling. PMID: 19910633 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Dejouvencel T, Féron D, Rossignol P, Sapoval M, Kauffmann C, Piot JM, Michel JB, Fruitier-Arnaudin I, Meilhac O Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data show that TZDs attenuate pathological retinal microvessel formation through APN-mediated modulation of TNF-alpha production. PMID: 19910632 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Higuchi A, Ohashi K, Shibata R, Sono-Romanelli S, Walsh K, Ouchi N Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: NKT cells play a crucial role in the development of adipose tissue inflammation and glucose intolerance in diet-induced obesity. PMID: 19910631 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 12, 2009 Category: Cardiology Authors: Ohmura K, Ishimori N, Ohmura Y, Tokuhara S, Nozawa A, Horii S, Andoh Y, Fujii S, Iwabuchi K, Onoé K, Tsutsui H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Bronchial Arteries: An Arteriosclerosis-Resistant CirculationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Respiration (DOI:10.1159/000257926) (Source: Karger Publishers)
Source: Karger Publishers - November 9, 2009 Category: Cancer & Oncology Source Type: journals

Vital Signs: Nutrition: Chocolate Milk May Reduce InflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect, though not as pronounced as with red wine, was seen in a Spanish study. (Source: NYT > Health)
Source: NYT > Health - November 9, 2009 Category: Consumer Health News Authors: By RONI CARYN RABIN Tags: arteriosclerosis and Atherosclerosis Milk Heart Chocolate Cholesterol Medicine and Health Source Type: news

Collagen-bound LDL modifies endothelial cell adhesion to type V collagen: Implications for atherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Low density lipoprotein (LDL) is retained in the extracellular matrix of the arterial wall where it is considered to be atherogenic, but little is known about how cell adhesion to the matrix is affected by collagen-bound LDL. We tested the effect of native, oxidized and acetylated LDL reacted with adsorbed monomeric type I, III and V collagen on endothelial cell adhesion to collagen using a colorimetric adhesion assay. We found that none of the LDL species affected adhesion to type I and III collagen, but that collagen-bound native and acetylated LDL enhanced attachment to type V collagen, whereas b...
Source: Central European Journal of Biology - November 5, 2009 Category: Biology Tags: Central European Journal of Biology Source Type: journals

Fibulin-2 and Fibulin-5 Cooperatively Function to Form the Internal Elastic Lamina and Protect From Vascular Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Fibulin-2 and fibulin-5 cooperatively function to form the IEL during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury. The DKO mouse will serve as a unique animal model to test the effect of vessel integrity during various pathological insults. PMID: 19893004 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 5, 2009 Category: Cardiology Authors: Chapman SL, Sicot FX, Davis EC, Huang J, Sasaki T, Chu ML, Yanagisawa H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CCL5 could participate in the inflammation of obese WAT by recruiting blood monocytes and exerting antiapoptotic properties on WAT macrophages. This specific role of CCL5 on macrophage survival with maintenance of their lipid scavenging function should be taken into account for future therapeutic strategies in obesity-related diseases. PMID: 19893003 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 5, 2009 Category: Cardiology Authors: Keophiphath M, Rouault C, Divoux A, Clément K, Lacasa D Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Accelerated arteriosclerosis: a form of transplant arteriopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PURPOSE OF REVIEW: Terminology for posttransplant renal arterial lesions is confusing, with multiple terms being applied, the more common among them being the comprehensive terms, transplant arteriosclerosis and transplant atherosclerosis; endarteritis, for intimal lesions with an inflammatory component; and finally for advanced lesions with or without intimal inflammation, transplant arteriopathy. However, these latter lesions may present the appearance of banal arteriosclerosis, albeit more advanced expected on the basis of donor age. This review explores the distinctions to be drawn among these various descriptive t...
Source: Current Opinion in Organ Transplantation - November 5, 2009 Category: Transplant Surgery Authors: Hill GS, Nochy D, Loupy A Tags: Curr Opin Organ Transplant Source Type: journals

Long Graft Cold Ischemia Time Is Associated With Increased Arterial Stiffness in Renal Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Long CIT was associated with increased arterial stiffness. Further studies are necessary to understand the cause effect relationship of this finding. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: P. Stróżecki, A. Adamowicz, M. Kozłowski, Z. Włodarczyk, J. Manitius Tags: Ischemia/Reperfusion Injury Source Type: journals

The Effects of C-Reactive Protein, Interleukin-6, and Tumor Necrosis Factor-α in Rat Allograft Adventitial Inflammation and Allograft ArteriosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to investigate the role of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) during allograft adventitial inflammation and arteriosclerosis. Lewis rats were used as donors and Wistar rats as recipients for the experimental groups, while both donors and recipients were Wistar rats in the control groups. The 36 experimental and 16 control allografts were divided into four groups (nine in each experimental and four in each control group): group A animals were euthanized at 1 week posttransplantation; groups B, C, and D animals were euthanized at 2, 3, and 4 weeks pos...
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: H. Sun, X. Lu, S. Wu, W. Sun Tags: Experimental Animal Models Source Type: journals

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This data provides, we believe for the first time, a more comprehensive understanding of Skp2 in the regulation of VSMC proliferation and neointimal formation and suggests that Skp2 is a promising target in the treatment of vasculoproliferative diseases.Clinical Relevance: This manuscript describes our latest work investigating the role of the Skp2, an F-box protein component of the SCFskp2 ubiquitin-ligase, in promoting VSMC proliferation, and neointima formation in response to vascular injury in vivo. Our previous work has identified a major role for Skp2 as a key target for numerous positive and negative gro...
Source: Journal of Vascular Surgery - October 30, 2009 Category: Surgery Authors: Yih-Jer Wu, Graciela B. Sala-Newby, Kuo-Tung Shu, Hung-I. Yeh, Keiichi I. Nakayama, Keiko Nakayama, Andrew C. Newby, Mark Bond Tags: Basic research studies Source Type: journals

Tyrosine sulfation of leukocyte adhesion molecules and chemokine receptors promotes atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19846834 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Koltsova E, Ley K Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Dimorphisms in the Membrane-Spanning Domain of EPCR Impact Systemic Coagulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19846835 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Esmon CT Tags: Arterioscler Thromb Vasc Biol Source Type: journals

The discovery of cellular immunity in the atherosclerotic plaque.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept. PMID: 19846836 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Hansson GK, Jonasson L Tags: Arterioscler Thromb Vasc Biol Source Type: journals

The Molecular Mechanisms of HDL and Associated Vesicular Trafficking Mechanisms to Mediate Cellular Lipid Homeostasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HDL functions mainly as a cholesterol scavenger, facilitating transport of cholesterol to the liver for conversion to bile acids and secretion into the bile for elimination or recycling in the enterohepatic bile acid cycle. Because of its major function in cholesterol clearance, HDL is in general considered to be atheroprotective. From cell cholesterol can be removed by efflux especially to apoA-I and HDL as extracellular acceptors which transport the cholesterol to the liver for excretion. This process is called reverse cholesterol transport. In this context the ATP binding cassette transporter protein ABCA1 facilitat...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 24, 2009 Category: Cardiology Authors: Schmitz G, Grandl M Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Dietary intake and plasma concentrations of PUFA and LC-PUFA in breastfed and formula fed infants under real-life conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Infants consuming present-day LC-PUFA-supplemented formula achieved plasma LC-PUFA concentrations similar to breastfed infants. In infants consuming non-LC-PUFA-supplemented formula, the favorable PUFA pattern of the formula may have supported n-3 LC-PUFA biosynthesis. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s00394-009-0067-1Authors Jana Schwartz, Rheinische Friedrich-Wilhelms-Universität Bonn Research Institute of Child Nutrition Dortmund Heinstück 11 44225 Dortmund GermanyClaudia Drossard, Rheinische Friedrich-Wilhelms-Universität Bonn Research Institute o...
Source: European Journal of Nutrition - October 22, 2009 Category: Nutrition Tags: European Journal of Nutrition Source Type: journals

PON-1 dysregulation in obesity linked to reduced cellular repair, protectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reduced paraoxonase -1 activity may be one mechanism underlying the accelerated cellular oxidative damage and arteriosclerosis seen in obese individuals, say Italian researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - October 21, 2009 Category: Lipidology Source Type: news

Assessment of cardiovascular risk in paediatric peritoneal dialysis patients: a Turkish Pediatric Peritoneal Dialysis Study Group (TUPEPD) reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Elevated levels of atherosclerotic/ inflammatory risk factors, low haemoglobin levels and loss of residual renal function and their negative effects on heart are of remarkable importance in paediatric patients on maintenance peritoneal dialysis. Achieving recommended targets for haemoglobin, blood pressure and Kt/V urea, preserving residual renal function as well as managing inflammation and subsequent arteriosclerosis is obviously essential to improve the patients’ prognosis. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - October 15, 2009 Category: Urology & Nephrology Authors: Bakkaloglu, S. A., Saygili, A., Sever, L., Noyan, A., Akman, S., Ekim, M., Aksu, N., Doganay, B., Yildiz, N., Duzova, A., Soylu, A., Alpay, H., Sonmez, F., Civilibal, M., Erdem, S., Kardelen, F. Tags: Dialysis Source Type: journals

HDL-paraoxonase and Membrane Lipid Peroxidation: A Comparison Between Healthy and Obese Subjects.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the decrease of HDL-PON activity and the lower HDL protective action against membrane peroxidation in obese patients could contribute to accelerate the cellular oxidative damage and arteriosclerosis in obesity. PMID: 19834469 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - October 14, 2009 Category: Eating Disorders and Weight Management Authors: Ferretti G, Bacchetti T, Masciangelo S, Bicchiega V Tags: Obesity (Silver Spring) Source Type: journals

Anthropometric Measures of Obesity and Risk of Venous Thromboembolism. The Tromso Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our findings indicate that WC is the preferable anthropometric measure of obesity to identify subjects at risk and to predict risk of VTE. PMID: 19834110 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Borch KH, Brækkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Bone Marrow AT1 Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitors via Platelet-Derived SDF-1{alpha}Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The BM-AT1 receptor promotes neointima formation by regulating the mobilization and homing of BM-derived VPCs in a platelet-derived SDF-1alpha-dependent manner without affecting EPC-mediated reendothelialization. PMID: 19834109 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Kato T, Matsui A, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H Tags: Arterioscler Thromb Vasc Biol Source Type: journals

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: JAK/STAT is a key regulator of Nox1 and Nox4 in human vascular SMCs. Inhibition of JAK/STAT pathway and the consequent Nox-dependent oxidative stress may be an efficient therapeutic strategy to reduce atherogenesis. PMID: 19834108 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Manea A, Irina Tanase L, Raicu M, Simionescu M Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Adenosine Modulates HIF-1{alpha}, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study provides the first evidence that A3, A2B, or mixed A3/A2B antagonists may be useful to block important steps in the atherosclerotic plaque development ado-induced. PMID: 19834107 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Gessi S, Fogli E, Sacchetto V, Merighi S, Varani K, Preti D, Leung E, Maclennan S, Borea PA Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism. Results From the E3N Cohort Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this large study, we found that route of estrogen administration and concomitant progestogens type are 2 important determinants of thrombotic risk among postmenopausal women using hormone therapy. Transdermal estrogens alone or combined with progesterone might be safe with respect to thrombotic risk. PMID: 19834106 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Canonico M, Fournier A, Carcaillon L, Olié V, Plu-Bureau G, Oger E, Mesrine S, Boutron-Ruault MC, Clavel-Chapelon F, Scarabin PY Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Molecular Imaging of the Initial Inflammatory Response in Atherosclerosis. Implications for Early Detection of Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Noninvasive ultrasound molecular imaging of endothelial activation can detect lesion-prone vascular phenotype before the appearance of obstructive atherosclerotic lesions. PMID: 19834105 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Kaufmann BA, Carr CL, Belcik JT, Xie A, Yue Q, Chadderdon S, Caplan ES, Khangura J, Bullens S, Bunting S, Lindner JR Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Familial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our data indicate that both men and women with FCH have alterations in the cholesterol synthesis pathway, resulting in 51% higher levels of lathosterol (and additionally desmosterol in women). Plasma levels of the cholesterol precursor sterol squalene were only slightly increased (6%), suggesting enhanced conversion of squalene to lathosterol in this disorder. PMID: 19834104 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: van Himbergen TM, Otokozawa S, Matthan NR, Schaefer EJ, Buchsbaum A, Ai M, van Tits LJ, de Graaf J, Stalenhoef AF Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: SCD1 ASO treatment in conjunction with dietary fish oil supplementation is an effective combination therapy to comprehensively combat the metabolic syndrome and atherosclerosis in mice. PMID: 19834103 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 14, 2009 Category: Cardiology Authors: Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen TM, Zhu X, Duong MN, Brown AL, Lord C, Shah R, Davis MA, Kelley K, Wilson MD, Madenspacher J, Fessler MB, Parks JS, Rudel LL Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Is lowering phosphate exposure the key to preventing arterial stiffening with age?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiovascular disease remains the leading cause of death world wide. Although atheroma is clearly important, the role of arteriosclerotic vascular disease is often overlooked. Arteriosclerosis causes increased arterial stiffness, with consequent systolic hypertension and left ventricular hypertrophy. Serum phosphate is increasingly being recognised as a cardiovascular risk factor and has been implicated in the development of arteriosclerosis and arterial calcification. Its determinants are unclear, but both diet and minor reductions in renal function may be important. Diets in affluent populations are high in phosphate be...
Source: Heart - October 14, 2009 Category: Cardiology Authors: Ferro, C J, Chue, C D, Steeds, R P, Townend, J N Tags: Viewpoints Source Type: journals

Use of structure-based virtual screening in the investigation of novel human sialidase inhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recent studies have determined the molecular mechanisms underlying the pathological alterations of sialic acid or its conjugates in various human disease states, and the sialic acid modifying enzyme sialidase has been adopted as an attractive therapeutic option for diseases like cancer, diabetes, inflammation, and arteriosclerosis. Isoform human sialidase inhibitors are also a good chemical tool for exploring the differential functions of human sialidases. In the current study, structure-based virtual screening was attempted to identify the compounds containing novel structures for human sialidase i...
Source: Medicinal Chemistry Research - October 14, 2009 Category: Chemistry Tags: Medicinal Chemistry Research Source Type: journals

High-Density Lipoprotein-Based Contrast Agents for Multimodal Imaging of Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lipoproteins, natural nanoparticles, have a well-recognized biological role and are highly suitable as a platform for delivering imaging agents. The ease with which both the exterior and interior of the particles can be modified permits the creation of multifunctional nanoparticles for imaging as well as the delivery of therapeutics. Importantly, their endogenous nature may make them biocompatible and biodegradable and allows them to avoid the recognition of the reticuloendothelial system. In particular, high-density lipoproteins (HDL) are of interest, because of their small size they can easily cross the endothelium a...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Skajaa T, Cormode DP, Falk E, Mulder WJ, Fisher EA, Fayad ZA Tags: Arterioscler Thromb Vasc Biol Source Type: journals

Alzheimer Disease-Associated Peptide, Amyloid {beta}40, Inhibits Vascular Regeneration With Induction of Endothelial Autophagy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our present findings indicate that the initial progression of AD might be in part driven by Abeta40-induced endothelial autophagy and impairment of neurovascular regeneration, suggesting important implications for therapeutic approaches to AD. PMID: 19815818 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 7, 2009 Category: Cardiology Authors: Hayashi SI, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R Tags: Arterioscler Thromb Vasc Biol Source Type: journals