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Neurological manifestations in Baggio-Yoshinari Syndrome (Brazilian Lyme disease-like syndrome)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The BYS is considered a new tick borne disease in Brazil that differs from classical LD observed in the Northern hemisphere. BYS replicates most of the neurological symptoms observed in LD, except for the additional presence of relapsing episodes and the tendency to cause chronic neurological and articular manifestations. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Frequency of antibodies against the etiologic agents of acquired imunodeficiency syndrome, syphilis, hepatitis B and C, and Chagas' disease in patients with rheumatic diseases treated with anti-tumor necrosis factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The frequency of seropositivity for different infectious diseases in patients under anti-TNF therapy is low. Individuals with positive serology for hepatitis C deserve close attention. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Cerebrospinal Fluid Neopterin and Cryopyrin-Associated Periodic SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cryopyrin-associated periodic syndrome is a category of autoinflammatory disorders caused by mutations of the NLRP3 gene, with chronic infantile neurologic cutaneous and articular syndrome being the severest clinical phenotype. Various pterins have been reported as mediating immunologic functions in the central nervous system, but to date studies of pterin cerebrospinal fluid (CSF) values and cryopyrin-associated periodic syndrome have been lacking. A 2-year-old child was affected with a severe atypical form of cryopyrin-associated periodic syndrome, suspected based on the analysis of neopterin in CSF. He initially present...
Source: Pediatric Neurology - November 20, 2009 Category: Neurology Authors: Mercedes Serrano, Aida Ormazábal, Jordi Antón, Juan I. Aróstegui, Àngels García-Cazorla Tags: Case Reports Source Type: journals

Aspirin kills 400% more people than H1N1 swine fluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The CDC now reports that nearly 4,000 Americans have been killed by H1N1 swine flu. This number is supposed to sound big and scary, motivating millions of people to go out and pay good money to be injected with untested, unproven H1N1 vaccines. But let's put the number in perspective: Did you know that more than four times as many people are killed each year by common NSAID painkillers like aspirin?The July 1998 issue of The American Journal of Medicine explains it as follows:"Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for nonsteroidal anti-inflammatory dr...
Source: NaturalNews.com - November 20, 2009 Category: Consumer Health Advice Source Type: news

ACTEMRA Improves Signs and Symptoms in Children with Systemic Onset Juvenile Idiopathic Arthritis (sJIA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Roche announced today that ACTEMRA (tocilizumab, known as RoACTEMRA within the EU) successfully met its primary endpoint in a paediatric study of systemic onset Juvenile Idiopathic Arthritis (sJIA), by significantly improving disease signs and symptoms, a critical effectiveness measure of a sJIA treatment. (Source: Roche Investor Update)
Source: Roche Investor Update - November 20, 2009 Category: Pharmaceuticals Source Type: organizations

The effect of triptolide on CD4+ and CD8+ cells in the Peyer's patch of DA rats with collagen induced arthritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effect of triptolide on the CD4+ and CD8+ cell distribution in Peyer's patch cells and periphery lymphocytes and TGF-beta and IFN-gamma levels in periphery in collagen induced arthritis (CIA) in DA rats. CIA in the rat is a widely studied animal model of inflammatory polyarthritis, with similarities to RA, and the DA rat is one of most susceptible strains for CIA. Our data show that triptolide could lower the arthritic scores of CIA. The more CD8+ cells in the Peyer's patch, the more CD4+ cells in periphery. High level IFN-gamma and low level TGF-beta in periphery are observed in CIA rats...
Source: Natural Product Research - November 20, 2009 Category: Biochemistry Authors: Xiao C, Zhao L, Liu Z, Lu C, Zhao N, Yang D, Chen S, Tang JC, Chan A, Lu AP Tags: Nat Prod Res Source Type: journals

Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk. (Source: BMJ Online First)
Source: BMJ Online First - November 20, 2009 Category: Journals (General) Authors: Hippisley-Cox, J., Coupland, C. Tags: Liver disease, Smoking and tobacco, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Drugs: cardiovascular system, Menopause (including HRT), Asthma, Connective tissue disease, Degenerative joint disease, Drugs: m Source Type: journals

Cancer Risk Not Affected by Anti-TNF Therapies for Rheumatoid ArthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anti-tumor necrosis factor (TNF) agents do not increase the risk of cancer during the first few years of use for rheumatoid arthritis, according to one of the largest and longest duration population-based assessments to study this issue. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2009 Category: Consumer Health News Tags: Rheumatology Source Type: news

Answer to Case of the Month #158: Lymphocytic Interstitial PneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 52-year-old woman with a 10-year history of seropositive rheumatoid arthritis presented with insidious onset of breathlessness over a 6-month period. Clinical examination was unremarkable. She was acyanotic, not clubbed and on auscultation, there was good air entry bilaterally and no crepitations. Pulmonary function tests revealed a mild restrictive defect and reduced transfer factor. Chest radiograph showed haziness in the perihilar regions, with widespread nodularity. A high-resolution computed tomography was performed (). (Source: Canadian Association of Radiologists Journal)
Source: Canadian Association of Radiologists Journal - November 19, 2009 Category: Radiology Authors: Edward Hoey, Kshitij Mankad Tags: Canadian Residents' Corner Source Type: journals

Management, complications and clinical results of femoral head fracturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A systematic review of the literature was conducted to investigate data regarding femoral head fractures, particularly focusing on their management, complications and clinical results.Twenty-nine eligible articles, meeting prespecified inclusion criteria, reported on 453 femoral head fractures in 450 patients (mean age of 38.9 years with a mean follow-up of 55.6 months). 84.3% of patients had been victims of an automobile accident. The most widespread classification scheme used was that of Pipkin (65.4% of cases) whereas clinical results were evaluated mainly according to Thompson–Epstein criteria (63.3% of cas...
Source: Injury - November 19, 2009 Category: Orthopaedics Authors: P.V. Giannoudis, G. Kontakis, Z. Christoforakis, M. Akula, T. Tosounidis, C. Koutras Tags: Reviews Source Type: journals

Can EP4 Agonist Alleviate Gastric Lesions?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding. To mitigate NSAIDs' adverse effects on the stomach, misoprostol, a non-selective prostaglandin E1 (PGE1) analogue, has been prescribed as the first choice for prevention of NSAID-induced injuries, but often induces severe adverse effects. (Source: Pain / Anesthetics News From Medical News Today)
Source: Pain / Anesthetics News From Medical News Today - November 19, 2009 Category: Anesthesiology Tags: GastroIntestinal / Gastroenterology Source Type: news

HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HMGB1, an evolutionarily conserved chromosomal protein, was recently re-discovered to act as a "danger signal" (alarmin) to alert the innate immune system for the initiation of host defense or tissue repair. Extracellular HMGB1 can be either passively released from damaged/necrotic cells or secreted by activated immune cells. Upon stimulation, dendritic cells (DCs), macrophages and natural killer (NK) cells secrete high levels of HMGB1 into the intercellular milieu. HMGB1 is potent to target DCs, macrophages, neutrophils and CD4(+) T cells. It also upregulates the expression of BCL-XL by which it may prevent the elimin...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhang S, Zhong J, Yang P, Gong F, Wang CY Tags: Int J Clin Exp Pathol Source Type: journals

Biomarkers as tools for improved diagnostic and therapeutic monitoring in SLEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the major challenges in rheumatology is to overcome the classification criteria that previously defined SLE since the heterogeneity of the disease(s) appears to represent a complexity that likely substantially contributed to the failure of a number of recent trials. For those engaged in clinical trials, validated disease activity biomarkers which respond rapidly to treatment and are predictive of clinical response would greatly facilitate early decision making around futility and dose selection. Likewise, use of validated patient stratification biomarkers possibly in conjunction with autoantibody profiles and diseas...
Source: Arthritis Research and Therapy - November 19, 2009 Category: Rheumatology Authors: Michael SmithFalk HiepeThomas DornerGerd Burmester Source Type: journals

The incidence of juvenile rheumatoid arthritis in Quebec: a population data-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our population based incidence estimate was similar to others. Children and adolescents with JRA are heavy users of medical care. Additional study of environmental or climate- related triggers may be warranted. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - November 19, 2009 Category: Rheumatology Authors: Debbie Ehrmann FeldmanSasha BernatskyMichelle Houde Source Type: journals

Anti-TNF drugs do not seem to increase medium-term cancer risk in rheumatoid arthritis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Arthr Rheum Area: News Over a period of at least six years, treatment of rheumatoid arthritis (RA) with drugs inhibiting tumour necrosis factor -alpha (anti-TNF drugs) does not seem to raise the risk of cancer, according to a population-based observational study. Patients with RA may be at modestly increased risk of cancer, and there is some concern that the anti-TNF drugs may further increase the risk; however clinical trials are not long enough to detect whether this is so in practice. Observational studies are necessary to identify such risks, and this paper reports such a study using the population ...
Source: NeLM - Oncology - November 19, 2009 Category: Cancer & Oncology Source Type: organizations

Trial drug Lupuzor may treat lupusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with lupus may benefit from a new drug that is currently progressing through clinical trials, called Lupuzor. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 19, 2009 Category: Rheumatology Authors: arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Impact of stumbling may be enough to cause fractureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The sequence of events leading to a fracture may seem clear - a trip and fall followed by a broken bone. However, new research suggests that in some cases, the force exerted on a bone when an elderly person stumbles is enough to cause a fracture by itself, before the person has even fallen. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 19, 2009 Category: Rheumatology Authors: arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Wright Medical Group, Inc. Announces Initial Release of the VALOR Ankle Fusion Nail SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New Foot & Ankle Product Solidifies Wrights Market-Leadership in Products for Surgical Treatment of Hindfoot Arthritis ARLINGTON, Tenn.--(HSMN NewsFeed)--Wright Medical Group, Inc. (NASDAQ: WMGI ), a global orthopaedic medical device company, today ann... Devices, OrthopaedicWright Medical Group, VALOR Ankle Fusion Nail, (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 18, 2009 Category: Pharmaceuticals Source Type: news

Impact of Adalimumab on Symptoms of Psoriatic Arthritis in Patients with Moderate to Severe Psoriasis: A Pooled Analysis of Randomized Clinical TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dermatology (DOI:10.1159/000260371) (Source: Dermatology)
Source: Dermatology - November 18, 2009 Category: Dermatology Source Type: journals

Arthritis "healing" advert bannedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An advert claiming that a special patch can help to heal arthritis, back pain, sciatica and fibromyalgia has been banned by the advertising watchdog (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 18, 2009 Category: Drugs & Pharmacology Source Type: news

Benefit-Risk Assessment of Leflunomide: An Appraisal of Leflunomide in Rheumatoid Arthritis 10 Years After LicensingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Drug Safety)
Source: Drug Safety - November 18, 2009 Category: Drugs & Pharmacology Authors: Alcorn, NicolaSaunders, SarahMadhok, Rajan Tags: Review Article Source Type: journals

Is primary care research a lost cause?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 18, 2009 Category: Journals (General) Authors: Mar, C. D. Tags: Liver disease, Infectious diseases, General practice / family medicine, Immunology (including allergy), Drugs: cardiovascular system, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis EDITORIALS Source Type: journals

Health Tip: Help Prevent BunionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Health Tip: Help Prevent BunionsCategory: Health NewsCreated: 11/18/2009 8:10:00 AMLast Editorial Review: 11/18/2009 (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - November 18, 2009 Category: Rheumatology Source Type: consumer

Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, to determine whether CREB is implicated in IL-6 production from arthritic synovial cells, a dominant negative molecule of activation transcription factor 1 (ATF-1) was transfected into synovial cells obtained from arthritic joints of env-pX rats. These transgenic rats carrying the env-pX gene of human T-cell leukemia virus type-1 develop destructive arthritis with high titers of serum rheumatoid factor and are thus regarded as a suitable model of RA. The dominant negative ATF-1 (ATF-1DN) constitutes a heterodimer with CREB and inhibits CREB function, as CREB/ATF-1DN heterodimers no longer bind to the tar...
Source: Modern Rheumatology - November 18, 2009 Category: Rheumatology Tags: Modern Rheumatology Source Type: journals

Pain relief patch advert bannedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An advert for a pain relief patch endorsed by tennis champion Virginia Wade is banned on the grounds it could mislead arthritis sufferers. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 18, 2009 Category: Consumer Health News Tags: UK Source Type: news

Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that aberrant CTGF production induced by TNFalpha plays a central role for the abnormal osteoclastic activation in RA patients. Restoration for dysregulation of CTGF production may contribute to the inhibition of articular destruction in infliximab treatment. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 18, 2009 Category: Rheumatology Authors: Kazuhisa NozawaMaki FujishiroMikiko KawasakiHiroshi KanekoKazuhisa IwabuchiMitsuaki YanagidaFujihiko SuzukiKeiji MiyazawaYoshinari TakasakiHideoki OgawaKenji TakamoriIwao Sekigawa Source Type: journals

'Hedgehog' proteins may hold key to osteoarthritis pain reliefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Canadian scientists believe they may have found a promising target for developing new osteoarthritis treatments. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 18, 2009 Category: Rheumatology Authors: arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Five exercises may ease neck and shoulder painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Danish scientists have found that office workers who suffer from neck and shoulder pain may benefit from doing five simple strength training exercises. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 18, 2009 Category: Rheumatology Authors: arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Heart disease was rife in ancient EgyptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
X-rays of mummies reveal atherosclerosis, suggesting there may be more to heart disease than bad diet and smokingHeart disease plagued human society long before fry-ups and cigarettes came along, researchers say. The upper classes of ancient Egypt were riddled with cardiovascular disease that dramatically raised their risk of heart attacks and strokes.Doctors made the discovery after taking hospital X-ray scans of 20 Egyptian mummies that date back more than 3,500 years.The scans revealed signs of atherosclerosis, a life-threatening condition where fat and calcium build up in the arteries, clogging them and stiffening thei...
Source: Guardian Unlimited Science - November 17, 2009 Category: Science Authors: Ian Sample Tags: Science Archaeology Nutrition Medical research Heart attack Heart and circulation problems in diabetes Life and style Health & wellbeing Society Egypt World news The Guardian Source Type: news

Low Vitamin D Levels May Raise Heart RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Low Vitamin D Levels May Raise Heart RiskCategory: Health NewsCreated: 11/17/2009 9:59:00 AMLast Editorial Review: 11/17/2009 9:59:51 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - November 17, 2009 Category: Rheumatology Source Type: consumer

Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that phosphorylated PYK2 in SLE PBMCs may induce the expression of CD40L and CTLA4, and subsequently the cell proliferation. PYK2 signaling enhances the autoreactive lymphocyte activation and plays an important role in the pathogenesis of SLE. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Meiying WangHongsheng SunWei ZhangYuanchao Zhang Source Type: journals

TWEAK: a novel biomarker for lupus nephritis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renal involvement is common in systemic lupus erythematosus. Early diagnosis of lupus nephritis (LN), allowing the instigation of appropriate therapy, remains an important clinical challenge. Current biomarkers in clinical practice are less than ideal lacking both sensitivity and specificity. In this issue of the Journal Schwartz and colleagues demonstrate the potential value of urinary TWEAK (uTWEAK) as a biomarker for LN. They show that uTWEAK is elevated in subjects with LN at diagnosis compared to those with SLE but no renal disease, and correlates with the degree of clinical disease activity. These data are thought pr...
Source: Arthritis Research and Therapy - November 17, 2009 Category: Rheumatology Authors: Neeraj DhaunDavid Kluth Source Type: journals

Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Aggrecanase-mediated aggrecanolysis, typical of degenerative articular cartilage, may play a physiologic role in the development of the immature bovine meniscus. IL-1-induced release of sGAG and loss of mechanical properties can be ascribed primarily to the activity of MMPs or aggrecanases other than ADAMTS-4 and ADAMTS-5. These results may have implications for the clinical management of osteoarthritis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 17, 2009 Category: Rheumatology Authors: Christopher WilsonEric VanderploegFengrong ZuoJohn SandyMarc Levenston Source Type: journals

UK physios 'unsure' about exercise benefits for osteoarthritis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many physiotherapists in the UK are uncertain about the benefits of exercise for people with osteoarthritis of the knee, a new survey has found. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 17, 2009 Category: Rheumatology Authors: arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Scientists study impact of rheumatoid arthritis on heart riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new study has confirmed that people with rheumatoid arthritis face a significantly heightened risk of heart disease. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - November 17, 2009 Category: Rheumatology Authors: arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Reg Windett obituaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Former wartime RAF pilot, he worked for the MoD helping to create the first radio approach system for planesThe great throng at the funeral of my friend Reg Windett, who has died aged 88, testified to an exceptionally well-lived life.He was born in Finchley, north London, the only son of Bert and Connie Windett. After leaving Haberdashers' Aske's school, he joined the RAF and flew Wellingtons for Coastal Command in the Mediterranean, surviving three crashes and nearly falling through a door which "some fool had left open". After the war, he worked for the Ministry of Defence, helping to create the first radio approach syst...
Source: Guardian Unlimited Science - November 16, 2009 Category: Science Tags: Aeronautics Air transport Poetry Golf The Guardian Obituaries Science Source Type: news

Infliximab and anterior optic neuropathy: case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00417-009-1227-yAuthors Jane W. Chan, University of Kentucky College of Medicine Department of Neurology and Ophthalmology KY Clinic L-445 Lexington KY 40536 USAAlberto Castellanos, Central Baptist Hospital Department of Internal Medicine Lexington KY 40503 USA Journal Graefe's Archive for Clinical and Experimental Ophthal...
Source: Graefe's Archive for Clinical and Experimental Ophthalmology - November 16, 2009 Category: Opthalmology Tags: Graefe's Archive for Clinical and Experimental Ophthalmology Source Type: journals

Response of elderly patients with rheumatoid arthritis to methotrexate or TNF inhibitors compared with younger patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Responsiveness of elderly patients with RA to MTX or TNFi+MTX is similar to that observed in patients of younger age. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Koller, M. D., Aletaha, D., Funovits, J., Pangan, A., Baker, D., Smolen, J. S. Tags: Pharmacology, Rheumatoid arthritis CLINICAL Source Type: journals

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results suggest that although IL-23 may have pathogenic activity in a proportion of patients with late-stage RA, it is not abundantly produced in this inflammatory tissue, nor does it have a dominant role in all patient tissues analysed. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Hillyer, P., Larche, M. J., Bowman, E. P., McClanahan, T. K., de Waal Malefyt, R., Schewitz, L. P., Giddins, G., Feldmann, M., Kastelein, R. A., Brennan, F. M. Tags: Rheumatoid arthritis CLINICAL Source Type: journals

Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This is the first study to show that the levels of the S100A4 protein are correlated with RA disease activity. Furthermore, only the bioactive form, but not the total amount of S100A4, decreases after successful TNF- blocking therapy in patients with RA. These data support an important role for the S100A4 multimer in the pathogenesis of RA. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Oslejskova, L., Grigorian, M., Hulejova, H., Vencovsky, J., Pavelka, K., Klingelhofer, J., Gay, S., Neidhart, M., Brabcova, H., Suchy, D., Senolt, L. Tags: Rheumatoid arthritis CLINICAL Source Type: journals

Cardiovascular morbidity and mortality remain similar in two cohorts of patients with long-standing rheumatoid arthritis seen in 1978 and 1995 in Malmo, SwedenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. There were similar elevations in the incidence of cardiovascular comorbidity in RA patients, identified two decades apart compared with the general population, in spite of more extensive treatment and reduced disease severity in the more recent cohort. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Bergstrom, U., Jacobsson, L. T. H., Turesson, C. Tags: Rheumatoid arthritis CLINICAL Source Type: journals

Arterial stiffness and cumulative inflammatory burden in rheumatoid arthritis: a dose-response relationship independent of established cardiovascular risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. In RA patients free of overt arterial disease, a dose–response relationship exists between cumulative inflammatory burden and arterial stiffness. This relationship is independent of established CV risk factors. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Crilly, M. A., Kumar, V., Clark, H. J., Scott, N. W., MacDonald, A. G., Williams, D. J. Tags: Rheumatoid arthritis CLINICAL Source Type: journals

No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Phipps-Green, A. J., Topless, R. K. G., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., Harrison, P., Wordsworth, B. P., Merriman, T. R. Tags: Rheumatoid arthritis, Systemic Lupus Erythematosus and Autoimmunity LETTERS TO THE EDITOR Source Type: journals

Comment on: Methotrexate pharmacogenomics in rheumatoid arthritis: introducing false positive report probabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Beretta, L. Tags: Pharmacology, Rheumatoid arthritis MATTERS ARISING Source Type: journals

Comment on: Methotrexate pharmacogenomics in rheumatoid arthritis: introducing false positive report probability: replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Dervieux, T. Tags: Pharmacology, Rheumatoid arthritis MATTERS ARISING Source Type: journals

Bone erosions at the distal ulna detected by ultrasonography are associated with structural damage assessed by conventional radiography and MRI: a study of patients with recent onset rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. A significant number of patients had US erosions at the distal ulna at baseline, with increased prevalence after 1 year. The US-detected erosions were associated with structural joint damage in hands assessed by both MRI and CR. US of the distal ulna could thus give useful clinical information. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Hammer, H. B., Haavardsholm, E. A., Boyesen, P., Kvien, T. K. Tags: Rheumatoid arthritis CLINICAL Source Type: journals

Fatigue is a reliable, sensitive and unique outcome measure in rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This study demonstrates that measures of fatigue are reliable and sensitive to change, and should be considered for inclusion as a core outcome measure in RA. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Minnock, P., Kirwan, J., Bresnihan, B. Tags: Rheumatoid arthritis CLINICAL Source Type: journals

Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. RF-positive rather than anti-CCP-positive RA patients with lower baseline disability and a lower number of previously failed TNF blockers may be the best candidates to RTX. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Quartuccio, L., Fabris, M., Salvin, S., Atzeni, F., Saracco, M., Benucci, M., Cimmino, M., Morassi, P., Masolini, P., Pellerito, R., Cutolo, M., Puttini, P. S., De Vita, S. Tags: Pharmacology, Rheumatoid arthritis CLINICAL Source Type: journals

Benefits of ultrasonography in the management of early arthritis: a cross-sectional study of baseline data from the ESPOIR cohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. US on six joints detected 1.4-fold more patients with erosions (3.3-fold more with the usual reading). In clinical practice, US combined with X-rays is of helpful diagnostic value in EA. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Funck-Brentano, T., Etchepare, F., Joulin, S. J., Gandjbakch, F., Pensec, V. D., Cyteval, C., Miquel, A., Benhamou, M., Banal, F., Le Loet, X., Cantagrel, A., Bourgeois, P., Fautrel, B. Tags: Rheumatoid arthritis CLINICAL Source Type: journals