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Mother’s Depression a Risk Factor in Childhood Asthma Symptoms, Study Suggests-11/19/09email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children’s Center published online in the Journal of Pediatric Psychology. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - November 21, 2009 Category: Research Source Type: news

Sweet! Sugared Polymer a New Weapon Against Allergies and Asthma-11/19/09email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - November 21, 2009 Category: Research Source Type: news

Do Endotoxin and Air Pollution Have a Synergistic Relationship to Asthma Onset or Exacerbation?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19923399 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 21, 2009 Category: Respiratory Medicine Authors: Delfino RJ Tags: Am J Respir Crit Care Med Source Type: journals

Identifying Chronic Obstructive Pulmonary Disease and Asthma by Exhaled Breath Analysis: Does the (e)Nose Know?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19923400 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 21, 2009 Category: Respiratory Medicine Authors: Machado RF Tags: Am J Respir Crit Care Med Source Type: journals

Mother's Depression A Risk Factor In Childhood Asthma Symptomsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Maternal depression can worsen asthma symptoms in their children, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 21, 2009 Category: Consumer Health News Tags: Respiratory / asthma Source Type: news

Mother's Depression A Risk Factor In Childhood Asthma Symptomsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Maternal depression can worsen asthma symptoms in their children, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology. (Source: Pediatrics News From Medical News Today)
Source: Pediatrics News From Medical News Today - November 21, 2009 Category: Pediatrics Tags: Respiratory / asthma Source Type: news

Particles From Car Brakes Harm Lung Cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Real-life particles released by car brake pads can harm lung cells in vitro. Researchers writing in BioMed Central's open access journal Particle and Fibre Toxicology found that heavy braking, as in an emergency stop, caused the most damage, but normal breaking and even close proximity to a disengaged brake resulted in potentially dangerous cellular stress. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 21, 2009 Category: Consumer Health News Tags: Respiratory / asthma Source Type: news

Phthalates, Common Plastics Chemicals, Linked To ADHD Symptomsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Phthalates are important components of many consumer products, including toys, cleaning materials, plastics, and personal care items. Studies to date on phthalates have been inconsistent, with some linking exposure to these chemicals to hormone disruptions, birth defects, asthma, and reproductive problems, while others have found no significant association between exposure and adverse effects. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 21, 2009 Category: Consumer Health News Tags: ADHD Source Type: news

Phthalates, Common Plastics Chemicals, Linked To ADHD Symptomsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Phthalates are important components of many consumer products, including toys, cleaning materials, plastics, and personal care items. Studies to date on phthalates have been inconsistent, with some linking exposure to these chemicals to hormone disruptions, birth defects, asthma, and reproductive problems, while others have found no significant association between exposure and adverse effects. (Source: ADHD News From Medical News Today)
Source: ADHD News From Medical News Today - November 21, 2009 Category: Pediatrics Tags: ADHD Source Type: news

Particles From Car Brakes Harm Lung Cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Real-life particles released by car brake pads can harm lung cells in vitro. Researchers writing in BioMed Central's open access journal Particle and Fibre Toxicology found that heavy braking, as in an emergency stop, caused the most damage, but normal breaking and even close proximity to a disengaged brake resulted in potentially dangerous cellular stress. (Source: Public Health News From Medical News Today)
Source: Public Health News From Medical News Today - November 21, 2009 Category: Primary Care Tags: Respiratory / asthma Source Type: news

FDA Advisory Committee Finds Data Support The Claim That SPIRIVA(R) HandiHaler(R) Reduces COPD Exacerbationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The U.S. Food and Drug Administration (FDA) Pulmonary-Allergy Drugs Advisory Committee voted 11 to 1 that clinical data included in a supplemental new drug application (sNDA) provide substantial and convincing evidence to support the claim that SPIRIVA® HandiHaler® (tiotropium bromide inhalation powder) reduces exacerbations (worsening of symptoms) in patients with chronic obstructive pulmonary disease (COPD). (Source: Asthma / Respiratory News From Medical News Today)
Source: Asthma / Respiratory News From Medical News Today - November 21, 2009 Category: Respiratory Medicine Tags: COPD Source Type: news

The olfactory system is affected by steroid aerosol treatment in miceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Asthma needs continuous treatment often for years. In humans, some drugs are administered via aerosol, therefore they come in contact with both respiratory and olfactory mucosa. We explored the possibility that antiasthma corticosteroid treatment could influence the olfactory function by passage through the nose. A group of mice was exposed twice daily for 42 days to fluticasone propionate aerosol and was compared with a control group. Olfactory behavior, respiratory mechanics, histology, and immunoreactivity in the olfactory system were assessed. Fluticasone-treated mice were slower in retrieving a piece of hidden food, b...
Source: AJP: Lung Cellular and Molecular Physiology - November 21, 2009 Category: Respiratory Medicine Authors: Mucignat-Caretta, C., Bondi, M., Rubini, A., Calabrese, F., Barbato, A. Tags: ARTICLES Source Type: journals

Recommendations for assessing Patient-Reported Outcomes and Health-Related quality of life in clinical trials on allergy: a GA2LEN taskforce position paperemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The aim of this Global Allergy and Asthma European Network (GA2LEN) consensus report is to provide recommendations for patient-reported outcomes (PROs) evaluation in clinical trials for allergic diseases, which constitute a global health problem in terms of physical, psychological economic and social impact. During the last 40 years, PROs have gained large consideration and use in the scientific community, to gain a better understanding of patients' subjective assessment with respect to elements concerning their health condition. They include all health-related reports coming from the patient, without involvement or interp...
Source: Allergy - November 21, 2009 Category: Allergy & Immunology Authors: I. Baiardini, P. J. Bousquet, Z. Brzoza, G. W. Canonica, E. Compalati, A. Fiocchi, W. Fokkens, R. G. van Wijk, S. La Grutta, C. Lombardi, M. Maurer, A. M. Pinto, E. Ridolo, G. E. Senna, I. Terreehorst, A. Todo Bom, J. Bousquet, T. Zuberbier, F. Braido Source Type: journals

Sweet! Sugared Polymer A New Weapon Against Allergies And Asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way. For more than a decade, a team led by Bruce S. Bochner, M.D. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Allergy Source Type: news

Sweet! Sugared Polymer A New Weapon Against Allergies And Asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way. For more than a decade, a team led by Bruce S. Bochner, M.D. (Source: Allergy News From Medical News Today)
Source: Allergy News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Allergy Source Type: news

Child asthma, mother's depression linkedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BALTIMORE, Nov. 20 (UPI) -- Maternal depression may aggravate a child's asthma but how often a child had symptoms did not seem to affect the mother's symptoms, U.S. researchers said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 20, 2009 Category: Consumer Health News Source Type: news

Beta-2 Receptor Variants Don't Affect LABA Response in Asthma (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Against expectations, asthma patients with different genotypes for the beta-2 adrenergic receptor all responded well to long-acting beta agonist (LABA) asthma drugs, researchers said. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - November 20, 2009 Category: Allergy & Immunology Source Type: news

Consistently poorly controlled asthma predicts exacerbationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Consistently very poorly controlled asthma is a significant predictor for exacerbations in both children and adults, study results show. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - November 20, 2009 Category: Respiratory Medicine Source Type: news

Five Tricks to Help Stressed Stepparents Enjoy the Holidaysemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A special guest post by stepmother, researcher, and author Jacquelyn Fletcher (A Career Girl's Guide to Becoming a Stepmom). While it's written specifically with stepmothers in mind, men with stepkids can benefit from Jacque's insights here as well...As Thanksgiving approaches, instead of feeling the warm anticipation of a day to spend with family, stepmothers across America are downing antacids. And really it's no surprise. "All of our experimental and clinical research confirms that the sense of having little or no control is always distressful," says Paul J. Rosch, MD, a clinical professor of medicine and psychiatry at ...
Source: Psychology Today Relationships Center - November 20, 2009 Category: Psychiatry & Psychology Authors: Wednesday Martin, Ph.D. Tags: Parenting Relationships Self-Help Source Type: consumer

Depression in the mother and asthma in the childemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Asthma symptoms can worsen in children with depressed mothers, as per research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology. Analyzing data from interviews with 262 mothers of African-American children with asthma - a population disproportionately affected by this inflammatory airway disorder - the Hopkins researchers observed that children whose mothers had more depressive symptoms had more frequent asthma symptoms during the six-months of the study. On the other hand, children whose mothers reported fewer depressive symptoms had less frequent asthma symptoms........ (Source...
Source: Medicineworld.org: New Article Alert - November 20, 2009 Category: Consumer Health News Source Type: info

A new weapon against allergies and asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Researchers at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - November 20, 2009 Category: Consumer Health News Source Type: info

A Risk Factor In Childhood Asthma Symptoms May Be Mother's Depressionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology. (Source: Depression News From Medical News Today)
Source: Depression News From Medical News Today - November 20, 2009 Category: Psychiatry Tags: Depression Source Type: news

Altair Therapeutics Announces Commencement Of A Multi-Center Phase IIa Clinical Trial Of Inhaled AIR645 To Treat Asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Altair Therapeutics, Inc., a privately-held, biopharmaceutical company developing novel therapeutics for respiratory diseases, announced the commencement of its IL-4 receptor alpha inhibitor bronchoprovocation trial. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Respiratory / asthma Source Type: news

A Risk Factor In Childhood Asthma Symptoms May Be Mother's Depressionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Asthma symptoms can worsen in children with depressed mothers, according to research from Johns Hopkins Children's Center published online in the Journal of Pediatric Psychology. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Depression Source Type: news

Asthma A Significant Risk Factor For Complications In Children With H1N1email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu. The study (http://www.cmaj.ca/cgi/rapidpdf/cmaj.091724), led by researchers from The Hospital for Sick Children (SickKids) in Toronto, Ontario, is published online in CMAJ (Canadian Medical Association Journal). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Swine Flu Source Type: news

Asthma A Significant Risk Factor For Complications In Children With H1N1email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu. The study (http://www.cmaj.ca/cgi/rapidpdf/cmaj.091724), led by researchers from The Hospital for Sick Children (SickKids) in Toronto, Ontario, is published online in CMAJ (Canadian Medical Association Journal). (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Swine Flu Source Type: news

Altair Therapeutics Announces Commencement Of A Multi-Center Phase IIa Clinical Trial Of Inhaled AIR645 To Treat Asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Altair Therapeutics, Inc., a privately-held, biopharmaceutical company developing novel therapeutics for respiratory diseases, announced the commencement of its IL-4 receptor alpha inhibitor bronchoprovocation trial. Study AIR645-CS2 is a phase 2, multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and efficacy of inhaled AIR645 in suppressing the asthmatic response in subjects with mild asthma. (Source: Asthma / Respiratory News From Medical News Today)
Source: Asthma / Respiratory News From Medical News Today - November 20, 2009 Category: Respiratory Medicine Tags: Respiratory / asthma Source Type: news

American Nurses Association Backs New Report Describing Effects Of Coal Pollution On Healthemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The American Nurses Association (ANA) joined other health care groups to support the Physicians for Social Responsibility's (PSR) newly-released report, "Coal's Assault on Human Health." Registered nurses see the effects of coal-generated pollution on the health of newborns who have elevated mercury levels and on patients with lung or cardiac disease. The PSR report concludes that coal contributes to four of the top five causes of mortality in the U.S. (Source: Asthma / Respiratory News From Medical News Today)
Source: Asthma / Respiratory News From Medical News Today - November 20, 2009 Category: Respiratory Medicine Tags: Water - Air Quality / Agriculture Source Type: news

Mother's depression a risk factor in childhood asthma symptoms, study suggestsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Maternal depression can worsen asthma symptoms in their children, according to new research. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news

U-M Opens New Research Studies For Emphysema & Other COPDemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Why do some smokers develop lung disease and others don't? And just how effective is supplemental oxygen therapy in treating patients with emphysema? The University of Michigan Health System will try to find out, through two new multi-center research studies that seek to improve diagnosis and treatment for millions of people affected by emphysema, chronic bronchitis and other lung diseases. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Respiratory / asthma Source Type: news

EFA Highlights The Urgent Need For Change And A Comprehensive European Strategy To Fight Chronic Obstructive Pulmonary Diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The European Federation of Allergy and Airways Diseases Patients Associations (EFA) today launched a book comparing and analysing the situation of Chronic Obstructive Pulmonary Disease (COPD) in Europe for the first time from the patients' perspective. The Book highlights and urgent need to reduce the suffering and mortality from this disease, which will - if not tackled appropriately - be the third leading cause of death worldwide by 2030. (Source: Asthma / Respiratory News From Medical News Today)
Source: Asthma / Respiratory News From Medical News Today - November 20, 2009 Category: Respiratory Medicine Tags: COPD Source Type: news

U-M Opens New Research Studies For Emphysema & Other COPDemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Why do some smokers develop lung disease and others don't? And just how effective is supplemental oxygen therapy in treating patients with emphysema? The University of Michigan Health System will try to find out, through two new multi-center research studies that seek to improve diagnosis and treatment for millions of people affected by emphysema, chronic bronchitis and other lung diseases. Together, those conditions are known as chronic obstructive pulmonary disease (COPD). (Source: Asthma / Respiratory News From Medical News Today)
Source: Asthma / Respiratory News From Medical News Today - November 20, 2009 Category: Respiratory Medicine Tags: Respiratory / asthma Source Type: news

Aspirin kills 400% more people than H1N1 swine fluemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(NaturalNews) The CDC now reports that nearly 4,000 Americans have been killed by H1N1 swine flu. This number is supposed to sound big and scary, motivating millions of people to go out and pay good money to be injected with untested, unproven H1N1 vaccines. But let's put the number in perspective: Did you know that more than four times as many people are killed each year by common NSAID painkillers like aspirin?The July 1998 issue of The American Journal of Medicine explains it as follows:"Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for nonsteroidal anti-inflammatory dr...
Source: NaturalNews.com - November 20, 2009 Category: Consumer Health Advice Source Type: news

Asthma Combo Seems Less Influenced by Genesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Title: Asthma Combo Seems Less Influenced by GenesCategory: Health NewsCreated: 11/20/2009 12:10:00 AMLast Editorial Review: 11/20/2009 (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - November 20, 2009 Category: Respiratory Medicine Source Type: consumer

Exercise-induced asthma: Preventive steps can ease symptomsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Exercise-induced asthma — Comprehensive overview covers treatment, symptoms of this type of asthma. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - November 20, 2009 Category: Consumer Health News Source Type: news

Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk. (Source: BMJ Online First)
Source: BMJ Online First - November 20, 2009 Category: Journals (General) Authors: Hippisley-Cox, J., Coupland, C. Tags: Liver disease, Smoking and tobacco, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Drugs: cardiovascular system, Menopause (including HRT), asthma, Connective tissue disease, Degenerative joint disease, Drugs: m Source Type: journals

[Comment] β2-receptor polymorphisms in asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In The Lancet today, Michael Wechsler and colleagues, from the Asthma Clinical Research Network (ACRN) of the US National Heart, Lung, and Blood Institute, report the LARGE study of the effects of a single-nucleotide polymorphism of the β2-adrenergic receptor on the addition of the longacting inhaled β2 agonist, salmeterol, to inhaled corticosteroid therapy. These investigators found significant improvements in baseline lung function as measured by morning peak expiratory flow with no genotype difference. They concluded that their data supported the current guideline recommendations for the use of these agonists in conju...
Source: LANCET - November 20, 2009 Category: Journals (General) Authors: H William Kelly Tags: Comment Source Type: journals

[Articles] Effect of β2-adrenergic receptor polymorphism on response to longacting β2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Some studies suggest that patients with asthma who are homozygous for arginine at the 16th aminoacid position of the β2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting β2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly). We investigated whether there is a genotype-specific response to treatment with a longacting β2 agonist in combination with inhaled corticosteroid. (Source: LANCET)
Source: LANCET - November 20, 2009 Category: Journals (General) Authors: Michael E Wechsler, Susan J Kunselman, Vernon M Chinchilli, Eugene Bleecker, Homer A Boushey, William J Calhoun, Bill T Ameredes, Mario Castro, Timothy J Craig, Loren Denlinger, John V Fahy, Nizar Jarjour, Shamsah Kazani, Sophia Kim, Monica Kraft, Stephen Tags: Articles Source Type: journals

Exhaled breath profiling can distinguish asthma from COPDemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Molecular profiling of exhaled breath using an “electronic nose” can accurately distinguish patients with asthma from those with chronic obstructive pulmonary disease, say Dutch researchers. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - November 20, 2009 Category: Respiratory Medicine Source Type: news

Cold-related respiratory symptoms in the general populationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Cold-related respiratory symptoms are common in patients with chronic respiratory diseases, but they start to emerge at relatively low temperatures. In a cold climate, the cold-related symptoms may have an impact on the health-related quality of life. Please cite this paper as: Harju T, Mäkinen T, Näyhä S, Laatikainen T, Jousilahti P and Hassi J. Cold-related respiratory symptoms in the general population. The Clinical Respiratory Journal 2009; DOI:10.1111/j.1752-699X.2009.00172.x. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 20, 2009 Category: Respiratory Medicine Authors: Terttu Harju, Tiina Mäkinen, Simo Näyhä, Tiina Laatikainen, Pekka Jousilahti, Juhani Hassi Source Type: journals

Asthma Combo Seems Less Influenced By Genesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Findings may not apply to blacks, researchers note Source: HealthDay Related MedlinePlus Topics: Asthma, Genes and Gene Therapy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 20, 2009 Category: Consumer Health News Source Type: consumer

FDA panel rejects omalizumab (Xolair®) for treatment of asthma in children aged 6 to 11email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Reuters Health News Area: News An advisory panel to the FDA has voted 10 to 4 against approval of omalizumab (Xolair®) for the treatment of asthma in children aged 6 to 11 years. The committee was split evenly on the effectiveness of the drug but voted by 9 to 5 that its safety record had not been adequately assessed. A member of the FDA's pulmonary and allergy products division told the meeting that while the drug had met its targets in clinical trials, its effectiveness in children was "invariably small and clinically modest." A decision by the FDA on this proposed paediatric use is expected in January 2010. Th...
Source: NeLM - News - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Beta2-receptor polymorphism doesn't seem to affect clinical response to LABA in asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Lancet Area: News Although there were apparent differences in test results, asthmatic patients with different polymorphisms of the beta2-adrenergic receptor had similar clinical responses to the combination or inhaled corticosteroid plus long-acting beta2 agonist (LABA) in a controlled trial.   There are genetically-determined variations in the beta2-receptor, with two possible amino acids (glycine, Gly, or arginine, Arg) in the 16 position; there is some evidence that patients who are B16 Arg/Arg may benefit less from LABA treatment than those who are B16 Gly/Gly and a retrospective analysis of clinical ...
Source: NeLM - News - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Bronchodilator effect of deep inspiration and bronchoconstriction-triggered coughemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: We found that methacholine-induced cough was associated with the bronchodilator effect of DI on methacholine induced-bronchoconstriction in normal subjects. (Source: BioMed Central)
Source: BioMed Central - November 20, 2009 Category: Journals (General) Authors: Noriyuki OhkuraMasaki FujimuraAkira TokudaJohsuke HaraAkihiro HoriMasaru NishitsujiMiki AboNobuyuki Katayama Source Type: journals

Salmeterol Found Similarly Effective in Asthma Genotypesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Outcomes in the long-acting β2 agonist in asthma trial showed no difference in treatment outcomes for patients taking salmeterol who had different B16 genotypes, according to a report in the Nov. 21 issue of The Lancet. (Source: Modern Medicine)
Source: Modern Medicine - November 20, 2009 Category: Journals (General) Source Type: info

Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthmaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background: Lysophosphatidic acid (LPA) plays a critical role in airway inflammation through G protein-coupled LPA receptors (LPA1-3). We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation. Methods: Wild type, LPA1 heterozygous knockout mice (LPA1+/-), and LPA2 heterozygous knockout mice (LPA2+/-) were sensitized with inactivated Schistosoma mansoni eggs and local antigenic challenge with Schistosoma mansoni soluble egg Ag (SEA) in the lungs. Bronchoalveolar larvage (BA...
Source: Respiratory Research - November 20, 2009 Category: Respiratory Medicine Authors: Yutong ZhaoJiankun TongDonghong HeSrikanth PendyalaBerdyshev EvgenyJerold ChunAnne SperlingViswanathan Natarajan Source Type: journals

H1N1 riskier for kids with asthma than regular fluemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Kids with asthma are at much higher risk of developing severe illness from H1N1 flu than they are with seasonal flu, a new Canadian study has found. (Source: CTV Health)
Source: CTV Health - November 19, 2009 Category: Consumer Health News Source Type: news

Asthma common in kids with severe H1N1: studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Asthma appears to be a significant risk factor for severe cases of disease in children who get the pandemic flu virus, compared to seasonal flu, Canadian researchers say. (Source: CBC | Health)
Source: CBC | Health - November 19, 2009 Category: Consumer Health News Source Type: news

H1N1 more a risk for kids with asthma than regular fluemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Kids with asthma are at much higher risk of developing severe illness from H1N1 flu than they are with seasonal flu, a new Canadian study has found. (Source: CTV Health)
Source: CTV Health - November 19, 2009 Category: Consumer Health News Source Type: news

Women Have a Lower Prevalence of Structural Heart Disease as a Precursor to Sudden Cardiac Arrest: The Ore-SUDS (Oregon Sudden Unexpected Death Study)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Women were significantly less likely than men to have a diagnosis of structural heart disease (LV dysfunction or coronary artery disease) before SCA. These findings suggest that fewer women may be eligible for prophylactic implantable cardioverter-defibrillator placement based on current guidelines and therefore may not have equal opportunity for prevention. Enhancement of SCA risk stratification may have even higher importance for women. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sumeet S. Chugh, Audrey Uy-Evanado, Carmen Teodorescu, Kyndaron Reinier, Ronald Mariani, Karen Gunson, Jonathan Jui Tags: Clinical Research Source Type: journals