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Assessment of 1p/19q status by fluorescence <i>in situ</i> hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and astrocytic tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion</b> : Loss of 1p/19q is strongly associated with oligodendroglial phenotype, while astrocytic tumors are more likely to show p53 over-expression. p53 expression and 1p/19q status appear to be mutually exclusive. (Source: Neurology India)
Source: Neurology India - November 20, 2009 Category: Neurology Authors: Shukla Bhaskar, Agarwal Shipra, Suri Vaishali, Pathak Pankaj, Sharma Mehar Chand, Gupta Deepak, Sharma Bhavani Shankar, Suri Ashish, Halder Ashutosh, Sarkar Chitra Source Type: journals

Goldhirsh Foundation 2010 Grant Cycle of the Brain Tumor Research Awards ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Goldhirsh Foundation is pleased to announce the 2010 Grant Cycle of the Brain Tumor Research Awards Program. The next application deadline is Thursday, January 7, 2010, 12:00 Noon, U.S. and Canada Eastern Time (GMT-5) for awards beginning on July 1, 2010. The Goldhirsh Foundation was established by Bernard A. Goldhirsh in 2000, shortly after he was diagnosed with brain cancer. Since his death in 2003, the Board of Directors of the Foundation (which includes his two children) has been shaping a grantmaking program that reflects his values and entrepreneurial spirit. We are dedicated to making a difference in the lives ...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: Goldhirsh Foundation Source Type: funding

Chronic uncal herniation secondary to posterior fossa shunting: case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that a negative pressure gradient in the posterior fossa, relative to the supratentorial compartment, is the etiology of the chronic uncal herniation in our patient. Comparing the case reports in the literature with our case, we postulate that chronic uncal herniation is a complication of shunting of a posterior fossa fluid cavity in children, many of them with Dandy–Walker syndrome and/or other cerebellar cystic formations. The treatment priority at presentation should be to rule out shunt malfunction. In the event of association with clinical over-drainage syndrome, there may be a ...
Source: Child's Nervous System - November 14, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Atypical Pilocytic Astrocytoma of the Third Ventricle Appearing as a Colloid CystEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00062-009-9016-xAuthors Ulrich Missler, Evangelisches und Johanniter Klinikum Niederrhein Central Division of Diagnostic and Interventional Neuroradiology Duisburg GermanyMichael Zimmermann, Evangelisches und Johanniter Klinikum Niederrhein Department of Neurosurgery Duisburg GermanyHolger Grehl, Evangelisches und Johanniter Klinikum Niederrhein Department of Neurology Duisburg Germany Journal Clinical NeuroradiologyOnline ISSN 1615-6706Print ISSN 0939-7116 (Source: Klinische Neuroradiologie)
Source: Klinische Neuroradiologie - November 12, 2009 Category: Neurology Tags: Clinical Neuroradiology Source Type: journals

Extracellular Osmolarity Modulates G protein-Coupled Receptor Dependent ATP Release from 1321N1 Astrocytoma Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported that ATP release from 1321N1 human astrocytoma cells could be stimulated either by activation of G protein-coupled receptors (GPCR) or hypotonic stress. Cheema et al. (12) have demonstrated that thrombin activation of protease-activated receptor 1 (PAR1) in 1321N1 cells and primary astrocytes acts synergistically with hypotonic stress to gate the opening of volume-sensitive organic osmolyte and anion channels (VSOAC) and that hypertonic stress strongly inhibits PAR1-gating of VSOAC. We tested the hypothesis that a VSOAC-type permeability might comprise a GPCR-regulated pathway for ATP export by d...
Source: American Journal of Physiology. Cell Physiology - November 11, 2009 Category: Cytology Authors: Blum AE, Walsh BC, Dubyak GR Tags: Am J Physiol Cell Physiol Source Type: journals

Pathologic intracellular signaling in childhood pilocytic astrocytomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Pomeroy, S. L. Tags: Primary brain tumor, Gene expression studies, Neurofibromatosis EDITORIALS Source Type: journals

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: BRAF rearrangement represents the most common genetic alteration in sporadic, but not neurofibromatosis type 1-associated, pilocytic astrocytomas (PAs). These findings implicate BRAF in the pathogenesis of these common low-grade astrocytomas in children, and suggest that PAs arise either from NF1 inactivation or BRAF gain of function. (Source: Neurology)
Source: Neurology - November 9, 2009 Category: Neurology Authors: Yu, J., Deshmukh, H., Gutmann, R. J., Emnett, R. J., Rodriguez, F. J., Watson, M. A., Nagarajan, R., Gutmann, D. H. Tags: Primary brain tumor, Gene expression studies, Neurofibromatosis ARTICLES Source Type: journals

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heterozygous point mutations of isocitrate dehydrogenase (IDH)1 codon 132 are frequent in grade II and III gliomas. Recently, we reported an antibody specific for the IDH1R132H mutation. Here we investigate the capability of this antibody to differentiate wild type and mutated IDH1 protein in central nervous system (CNS) tumors by Western blot and immunohistochemistry. Results of protein analysis are correlated to sequencing data. In Western blot, anti-IDH1R132H mouse monoclonal antibody mIDH1R132H detected a specific band only in mutated tumors. Immunohistochemistry of 345 primary brain tumors demonstrated a strong cytopl...
Source: Brain Pathology - November 9, 2009 Category: Neurology Authors: David Capper, Susanne Weißert, Jörg Balss, Antje Habel, Jochen Meyer, Diana Jäger, Ulrike Ackermann, Claudia Tessmer, Andrey Korshunov, Hanswalter Zentgraf, Christian Hartmann, Andreas von Deimling Source Type: journals

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE). About 664 patients with SCA and 1,057 patients with SCE were analyzed using the Surveillance, Epidemiology, and End Results database. For grade 1, 2, 3 and 4 SCA, the 5-year OS was 82, 70, 28 and 14%; the 5-year CSS was 89, 77, 36 and 20%. For SCA, lower grade, younger age, and undergoing resection significantly improved OS and CSS; treatment without radiotherapy was favorable for CSS. Smaller tumor size also improv...
Source: Journal of Neuro-Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Multiple extracranial metastases from secondary glioblastoma multiforme: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Extracranial metastasis of glioblastoma multiforme (GBM) is very rare, in spite of very aggressive tumor behavior and being documented in only a few patients. In this article we present a 25-year-old man with secondary glioblastoma associated with extracranial progression and distant metastasis. He was diagnosed by magnetic resononce (MR) with an intracranial lesion in the right parietofrontal region, which was subsequently resected. Histology revealed a diffuse astrocytoma (grade II). The tumor recurred 1 year later and the patient received a second craniotomy. A diagnosis of GBM was made. Aft...
Source: Journal of Neuro-Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[(18)F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new (18)F-labeled 2-nitroimidazole analog.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Imaging with FRP-170 PET can visualize hypoxic lesions in patients with glioma, as confirmed by histological examination. This new method can assess tumor hypoxia preoperatively and noninvasively. PMID: 19895196 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 6, 2009 Category: Neurosurgery Authors: Shibahara I, Kumabe T, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T Tags: J Neurosurg Source Type: journals

Correlation of glioma proliferation assessed by flow cytometry with 99mTc-Tetrofosmin SPECT uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: George A. Alexiou, Spyridon Tsiouris, George Vartholomatos, George Fotakopoulos, Athanasios Papadopoulos, Athanasios P. Kyritsis, Spyridon Voulgaris, Andreas D. Fotopoulos Tags: Original articles Source Type: journals

Therapy-related myelodysplastic syndrome/acute myeloid leukemia after treatment with temozolomide in a patient with glioblastoma multiforme.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Therapy-related myelodysplastic syndrome and acute leukemia after treatment with temozolomide have rarely been described in the literature. Only 10 cases in association with temozolomide have been documented. The cases included anaplastic astrocytoma (4 cases), anaplastic oligodendroglioma (2 cases), low grade astrocytoma (2 cases), low grade oligodendroglioma (1 case), and one case of secondary Philadelphia-positive acute lymphoblastic leukemia in a patient with glioblastoma multiforme. Here we report a novel case of therapy-related myelodysplastic syndrome/acute myeloid leukemia associated with der(1;7)(q10;p10) in a...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Kim SJ, Park TS, Lee ST, Song J, Suh B, Kim SH, Jang SJ, Lee CH, Choi JR Tags: Ann Clin Lab Sci Source Type: journals

Evaluation of intracranial space-occupying lesion with Tc99m-glucoheptonate brain single photon emission computed tomography in treatment-naïve patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions : Glucoheptonate has high degree of specificity for neoplastic tissues of brain and may be used as a tracer for SPECT study to differentiate neoplastic intracranial lesions from non-neoplastic ones. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - November 2, 2009 Category: Internal Medicine Source Type: journals

Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, not only shares a high degree of similarity with p53 in its primary sequence, but also has similar functions. Like p53, p73 can bind to DNA and activate transcription. Using PCR-SSCP and gene sequencing, we analyzed the TP53 and TP73 genes in a case of a grade III anaplastic astrocytoma that progressed to glioblastoma. We found a deletion of AAG at position 595-597 of TP53 (exon 6), resulting in the de...
Source: Genetics and Molecular Research - November 1, 2009 Category: Genetics & Stem Cells Authors: Anselmo NP, Rey JA, Almeida LO, Custódio AC, Almeida JR, Clara CA, Santos MJ, Casartelli C Tags: Genet Mol Res Source Type: journals

5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We confirmed the expression of 5-LO in various human brain tumors and demonstrated the partial suppression of tumor growth by inhibitors of the 5-LO-LTA4 hydrolase pathway in human glioma cell lines. The 5-LO-LTA4 pathway might play roles in the proliferation of human glioma cells. PMID: 19919819 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - November 1, 2009 Category: Pathology Authors: Ishii K, Zaitsu M, Yonemitsu N, Kan Y, Hamasaki Y, Matsuo M, Tags: Clin Neuropathol Source Type: journals

Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal disseminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the brain and leptomeninges was diagnosed, so the patient started chemotherapy with temozolomide and liposomal cytarabine. Complete remission was achieved after 12 months of treatment and the patient is still free from the disease after a follow-up of 24 months. We suggest that this ...
Source: Journal of Neuro-Oncology - October 30, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
g & C Choi (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - October 30, 2009 Category: Cytology Authors: K ChoiS-W RyuS SongH ChoiS W KangC Choi Source Type: journals

Hepatocyte growth factor in cerebrospinal fluid is associated with mortality and recurrence of glioblastoma, and could be of prognostic valueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Malignant gliomas—glioblastoma multiforme and anaplastic astrocytoma—are among the most fatal forms of cancer in humans. It has been suggested that hepatocyte growth factor (HGF) is a reliable predictor of glioma malignancy; amounts of HGF are directly related to cellular proliferation, angiogenesis, low apoptotic rate, and poor prognosis (WHO III and IV). We measured the HGF content of cerebrospinal fluid (CSF) from patients with malignant glioma glioblastoma multiforme (WHO IV; n = 14), anaplastic astrocytoma (WHO III; n = 4), and meningioma (WHO I; n = 9), and fro...
Source: Journal of Neuro-Oncology - October 25, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tuberous sclerosis complex (TSC) is associated with hamartomatous growths including subependymal giant cell astrocytomas (SEGAs). Since chemo-radiation therapies offer scant benefit, oncologists had traditionally been little involved in managing SEGAs. Recent evidence demonstrating rapamycin efficacy in adults and children with TSC-associated tumors foresee a practice change. We summarize our institutional experience and literature review that highlight potential benefits and hazards of rapamycin therapy, for TSC patients with SEGA, and other syndromal brain tumors. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: P...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Catherine Lam, Eric Bouffet, Uri Tabori, Donald Mabbott, Michael Taylor, Ute Bartels Source Type: journals

Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in ...
Source: Nutrition and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD Tags: Nutr Cancer Source Type: journals

Cytogenetic study of glioneuronal tumor with neuropil-like islands: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glioneuronal tumor with neuropil-like islands (GTNI) is a recently recognized glioneuronal neoplasm but it was classified as an astrocytic tumor by the World Health Organization (WHO) in 2007. We performed a cytogenetic study in a case of GTNI arising in a 55-year-old man and analyzed its genetic alteration. It presented as a heterogeneously enhancing, multi-lobulating solid mass on MRI. Histopathologically, the tumor showed the biphasic feature of the predominating micronodular neuropil-like islands and the diffusely infiltrating glial component. In addition, the prominent blood vessels with perivascular hyalinization wer...
Source: Neuropathology - October 20, 2009 Category: Neurology Authors: Hye Sook Min, Sang Hyun Lee, Heon Yoo, Jaekyung Myung, Eun Kyoung Hong, Sung-Hye Park Source Type: journals

Water Diffusivity: Comparison of Primary CNS Lymphoma and Astrocytic Tumor Infiltrating the Corpus CallosumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. The water diffusivity and the ADC ratio of the tumor to normal-appearing corpus callosum of astrocytic tumor differ significantly from those of lymphoma infiltrating the corpus callosum, allowing reliable differentiation of the two types of tumor. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - October 20, 2009 Category: Radiology Authors: Horger, M., Fenchel, M., Nagele, T., Moehle, R., Claussen, C. D., Beschorner, R., Ernemann, U. Tags: Neuroradiology/Head and Neck Imaging Source Type: journals

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the proper influence of sulfasalazine treatment on patient outcome was difficult to ascertain in these debilitated patients with a large tumor burden (median KPS=50), ISRCTN45828668 was terminated after its interim analysis. This study urges to exert cautiousness in future trials of Sulfasalazine for the treatment of malignant gliomas.Trial Registration: Current Controlled Trials ISRCTN45828668 (Source: BMC Cancer)
Source: BMC Cancer - October 18, 2009 Category: Cancer & Oncology Authors: Pierre RobeDidier MartinMinh Nguyen-KhacMaria ArtesiManuel DeprezAdelin AlbertSophie VanbelleStephane CalificeMarkus BredelVincent Bours Source Type: journals

Heparanase expression of glioma in human and animal models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Glioma tissues contain increased levels of heparanase. Multiple cell types contribute to the expression of heparanase, including neovessel endothelial cells, tumor cells, and infiltrated neutrophils. Heparanase plays an important role in the control of cell proliferation and invasion. Animal models using Ast11.9-2 and primary neurospheres are suitable for antitumor studies targeting heparanase. PMID: 19835469 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - October 15, 2009 Category: Neurosurgery Authors: Hong X, Nelson KK, Decarvalho AC, Kalkanis SN Tags: J Neurosurg Source Type: journals

Change in Intracellular pH Causes the Toxic Ca(2+) Entry via NCX1 in Neuron- and Glia-Derived Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brain hypoxia or ischemia causes acidosis and the intracellular accumulation of Ca(2+) in neuron. The aims of the present study were to elucidate the interaction between intracellular pH and Ca(2+) during transient acidosis and its effects on the viability of neuronal and glial cells. Intracellular Ca(2+) and pH were measured using the fluorescence of fura-2 and 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester in neuroblastoma (IMR-32), glioblastoma (T98G), and astrocytoma (CCF-STTG1) cell lines. The administration of 5 mM propionate caused intracellular acidification in IMR-32 and T98G cells but n...
Source: Cellular and Molecular Neurobiology - October 14, 2009 Category: Cytology Authors: Shono Y, Kamouchi M, Kitazono T, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida M Tags: Cell Mol Neurobiol Source Type: journals

In pursuit of prognostic factors in children with pilocytic astrocytomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Aside from GTR, no other clinical, histopathological, or immunohistochemical features were found to be related to the prognosis. We postulate that strict follow-up is recommended if piloA is associated with high mitotic activity/Ki67-LI, or if GTR cannot be achieved at surgery. Tumor recurrence or progression of the residual lesion should be strictly observed. In some aspects, childhood piloA remains an enigmatic tumor. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00381-009-0990-8Authors Aline Paixão Becker, University of São Paulo Department of Pathology, Ribeirão P...
Source: Child's Nervous System - October 13, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Integrated Molecular Analysis Suggests a Three-Class Model for Low-Grade Gliomas: A Proof-of-Concept Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Integration of genomic, transcriptomic, and morphologic data for class discovery suggests a three class model for low-grade gliomas. Class I represents tumors with molecular similarity to pilocytic astrocytomas, class II tumors are similar to 1p/19q codeleted oligodendrogliomas, and class III represents infiltrative low-grade gliomas. This classification is similar to current clinical paradigms for low-grade gliomas; our work suggests a molecular basis for such models. This classification may supplement or may serve as the basis for a molecular pathologic alternative to current grading schemes for low-grade gl...
Source: Genomics - October 12, 2009 Category: Genetics & Stem Cells Authors: Marko NF, Prayson RA, Barnett GH, Weil RJ Tags: Genomics Source Type: journals

Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a pilocytic astrocytoma of the CPA that was found to arise from the proximal portion of trigeminal nerve without any anatomic continuity with the brain stem and the cerebellum. Pre-operative MRI suggested a schwannoma. The proposed origin of this extremely rare tumor is the root entry zone of the involved nerve. The tumor was completely resected via a suboccipital retrosigmoid approach. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0020-4Authors Formica Francesco, Università Politecnica delle Marche Clinica di Neurochirurgia v. Conca no 71 60020 Ancona ItalyIacoangeli Maurizio,...
Source: Journal of Neuro-Oncology - October 10, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Pilocytic astrocytoma as a predominant component of a recurrent complex type DNT.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of a 7-year-old girl with a temporal lobe DNT, which recurred four years after subtotal resection of the tumour. In the recurrent lesion we identified pilocytic astrocytoma (PA) as a predominant component of the tumour. Small pieces of the removed tissues also disclosed remnants of DNT. Clinical presentation of the primary tumour consisted of partial simple seizures, while the recurrent tumour manifested with headache and vomiting. Likewise, the radiological appearance of both tumours was different. We conclude that patients with incompletely removed DNT may suffer local recurrence of that tumour....
Source: Folia Neuropathologica - October 9, 2009 Category: Pathology Authors: Zakrzewski K, Biernat W, Liberski PP, Polis L, Perek D, Nowoslawska E Tags: Folia Neuropathol Source Type: journals

Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The expression of protein RCAS1 (receptor-binding cancer antigen expressed on SiSo cells), possibly involved in the mechanisms of evasion of immune surveillance by tumours, has been studied in brain astrocytomas grade III and IV and in metastatic carcinomas to the brain by means of double immunofluorescence with antibodies against RCAS1 and respectively anti-GFAP (astroglia) or CD68 or CD74 (macrophages/microglia). Expression of RCAS1 has been reported in many types of carcinomas and in some normal cells, including bone marrow macrophages. Nakabayashi and coworkers recently reported expression of RCAS1 in gliomas. So f...
Source: Folia Neuropathologica - October 9, 2009 Category: Pathology Authors: Adamek D, Radwańska E, Gajda M Tags: Folia Neuropathol Source Type: journals

Brain Tumor: Anaplastic AstrocytomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anaplastic Astrocytoma is a primary grade III (malignant) brain tumor. Anaplastic Astrocytoma comprises about 4 percent of all primary brain tumors diagnosed in the United States. (Source: MyBiopsy.org)
Source: MyBiopsy.org - October 7, 2009 Category: Cancer & Oncology Source Type: consumer

Brain Tumor: GlioblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glioblastoma is a type of primary malignant brain tumor. Glioblastoma is also known as grade 4 (IV) astrocytoma, Glioblastoma multiforme and GBM. (Source: MyBiopsy.org)
Source: MyBiopsy.org - October 7, 2009 Category: Cancer & Oncology Source Type: consumer

Brain Tumor: Pilocytic AstrocytomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pilocytic Astrocytoma is a type of benign brain tumor that rarely spreads into surrounding tissues. Starting in brain cells called astrocytes, this type of tumor is slow-growing tumor but can become very large. (Source: MyBiopsy.org)
Source: MyBiopsy.org - October 7, 2009 Category: Cancer & Oncology Source Type: consumer

Thromboxane A(2) receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-delta and PKC-varepsilon in the shedding of epidermal growth factor receptor ligands.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined thromboxane A(2) receptor (TP)-mediated transactivation of epidermal growth factor receptor (EGFR) through the shedding of EGFR ligands. A TP agonist U46619 caused the phosphorylation of EGFR in 1321N1 human astrocytoma cells, which was inhibited by an EGFR selective inhibitor AG1478 and by a disintegrin and metalloproteinase (ADAM) inhibitor TAPI-2, indicating TP stimulation caused the EGFR transactivation through the EGFR ligand shedding. Since 1321N1 cells expressed heparin binding-EGF (HB-EGF) mRNA, the mechanism of TP-mediated EGFR transactivation was examined in HEK293 cells expressing alkaline phosphatas...
Source: European Journal of Pharmaceutical Sciences - October 1, 2009 Category: Drugs & Pharmacology Authors: Uchiyama K, Saito M, Sasaki M, Obara Y, Higashiyama S, Nakahata N Tags: Eur J Pharm Sci Source Type: journals

Monoclonal antibody specific for IDH1 R132H mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. We developed a mouse monoclonal antibody targeting the IDH1 R132H mutation. Here, we show the high specificity and sensitivity of this antibody on Western blots and tissue sections from formalin fixed paraffin embedded tumor specimens. This antibody is highly useful for tumor classification, in detecting single infiltrating tumor cells and for the characterization of the cellular role of mutant IDH1 protein. Content Type Journal ArticleCategory Short ReportDOI 10.1007/s00401-009-0595-zAuthors David Cap...
Source: Acta Neuropathologica - October 1, 2009 Category: Neurology Tags: Acta Neuropathologica Source Type: journals

Neurofibroma adjacent to the thyroid gland and a thyroid papillary carcinoma in a patient with neurofibromatosis type 1: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents a case of a neurofibroma adherent to the thyroid gland with thyroid papillary carcinoma in a 26-year-old woman with NF type 1. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00595-008-3946-9Authors Yavuz Koksal, Selcuk University Department of Pediatric Oncology Konya 42080 TurkeyMustafa Sahin, Selcuk University Department of General Surgery Konya 42080 TurkeyHande Koksal, Konya Numune State Hospital Department of General Surgery Konya TurkeyHasan Esen, Selcuk University Department of Pathology, Meram Faculty of Medicine Konya 42080 TurkeyMetin Sen, Selcuk University Department of P...
Source: Surgery Today - September 29, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Liver grafts from donors with central nervous system tumors: A single-center perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in our experience, despite violation of the blood-brain barrier and high-grade CNS tumors, recurrence was uncommon. Grafts from these donors are often an overlooked source of high-quality organs from younger donors and can be appropriately used, particularly in patients who, despite low Model for End-Stage Liver Disease scores, carry a high risk of mortality. Liver Transpl 15:1204-1208, 2009. © 2009 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - September 28, 2009 Category: Transplant Surgery Authors: Randeep Kashyap, Charlotte Ryan, Rajeev Sharma, Manoj K. Maloo, Saman Safadjou, Maureen Graham, David Tretheway, Ashokkumar Jain, Mark Orloff Tags: Original Articles Source Type: journals

Low-Grade Gliomas: Six-month Tumor Growth Predicts Patient Outcome Better than Admission Tumor Volume, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient [Neuroradiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Six-month tumor growth helps predict outcome in patients with LGG better than parameters derived from perfusion- or diffusion-weighed MR imaging. Tumor growth can readily be calculated from volume measurements on images acquired with standard MR imaging protocols and may well prove most useful among various MR imaging findings in clinical practice. © RSNA, 2009 (Source: Continuous Publishing articles)
Source: Continuous Publishing articles - September 28, 2009 Category: Radiology Authors: Brasil Caseiras, G., Ciccarelli, O., Altmann, D. R., Benton, C. E., Tozer, D. J., Tofts, P. S., Yousry, T. A., Rees, J., Waldman, A. D., Jager, H. R. Tags: Neuroradiology Source Type: journals

Low-Grade Gliomas: Six-month Tumor Growth Predicts Patient Outcome Better than Admission Tumor Volume, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Six-month tumor growth helps predict outcome in patients with LGG better than parameters derived from perfusion- or diffusion-weighed MR imaging. Tumor growth can readily be calculated from volume measurements on images acquired with standard MR imaging protocols and may well prove most useful among various MR imaging findings in clinical practice. (c) RSNA, 2009. PMID: 19789244 [PubMed - as supplied by publisher] (Source: Radiology)
Source: Radiology - September 28, 2009 Category: Radiology Authors: Brasil Caseiras G, Ciccarelli O, Altmann DR, Benton CE, Tozer DJ, Tofts PS, Yousry TA, Rees J, Waldman AD, Jäger HR Tags: Radiology Source Type: journals

Stereotactic biopsy for brainstem tumors in pediatric patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Stereotactic biopsy done for clarifiying a diagnostic imaging in brainstem tumors is important in obtaining a definitive diagnosis with a low rate of complications. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00381-009-1000-xAuthors José L. Pérez-Gómez, Instituto Nacional de Pediatría Departamento de Neurocirugía Pediátrica Insurgentes Sur 3700-C, Col. Insurgentes Cuicuilco, Deleg. Coyoacán Mexico C.P. 04530 Mexico D.F.Carlos A. Rodríguez-Álvarez, Instituto Nacional de Pediatría Departamento de Neurocirugía Pediátrica Insurgentes Sur 3700-C, Col. Insurgentes ...
Source: Child's Nervous System - September 28, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Pilocytic astrocytoma as a predominant component of a recurrent complex type DNTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of a 7-year-old girl with a temporal lobe DNT, which recurred four years after subtotal resection of the tumour. In the recurrent lesion we identified pilocytic astrocytoma (PA) as a predominant component of the tumour. Small pieces of the removed tissues also disclosed remnants of DNT. Clinical presentation of the primary tumour consisted of partial simple seizures, while the recurrent tumour manifested with headache and vomiting. Likewise, the radiological appearance of both tumours was different. We conclude that patients with incompletely removed DNT may suffer local recurrence of that tumour....
Source: Articles of Folia Neuropathologica - TERMEDIA publishing house - September 25, 2009 Category: Neurology Source Type: journals

Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The expression of protein RCAS1 (receptor-binding cancer antigen expressed on SiSo cells), possibly involved in the mechanisms of evasion of immune surveillance by tumours, has been studied in brain astrocytomas grade III and IV and in metastatic carcinomas to the brain by means of double immunofluorescence with antibodies against RCAS1 and respectively anti-GFAP (astroglia) or CD68 or CD74 (macrophages/microglia). Expression of RCAS1 has been reported in many types of carcinomas and in some normal cells, including bone marrow macrophages. Nakabayashi and co-workers recently reported expression of RCAS1 in gliomas. So far ...
Source: Articles of Folia Neuropathologica - TERMEDIA publishing house - September 25, 2009 Category: Neurology Source Type: journals

Anaplastic oligo-astrocytoma occurring after resection of a cerebral cavernous malformation; malignant transformation? Case report and review on etiologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 71-year-old woman who presented with a cerebral cavernous malformation in the right frontal lobe for which she underwent total resection. Three years later, she was admitted with seizures and neuroimaging revealed a partially calcified lesion in the area of the earlier cavernous malformation, consistent with a residual malformation. A few months later she presented with cognitive decline and neuroimaging now revealed a large mass lesion in the same area as the cavernous malformation, irregularly enhancing, spreading through the corpus callosum to the left frontal lobe. Histological examination showed an an...
Source: Journal of Neurology - September 24, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals

Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of GliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diffuse astrocytoma of World Health Organization (WHO) grade II has an inherent tendency to spontaneously progress to anaplastic astrocytoma WHO grade III or secondary glioblastoma WHO grade IV. We explored the role of microRNAs (miRNAs) in glioma progression by investigating the expression profiles of 157 miRNAs in four patients with primary WHO grade II gliomas that spontaneously progressed to WHO grade IV secondary glioblastomas. Thereby, we identified 12 miRNAs (miR-9, miR-15a, miR-16, miR-17, miR-19a, miR-20a, miR-21, miR-25, miR-28, miR-130b, miR-140 and miR-210) showing increased expression, and two miRNAs (miR-184 ...
Source: Brain Pathology - September 23, 2009 Category: Neurology Authors: Bastian Malzkorn, Marietta Wolter, Franziska Liesenberg, Michael Grzendowski, Kai Stühler, Helmut E. Meyer, Guido Reifenberger Source Type: journals

High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have chosen to study using different technical approaches (Q-RT-PCR, in situ hybridization and immunohistochemistry) the expression of five molecules involved in extracellular matrix degradation (cathepsin B, MMP2, MMP9, uPA and PAI-1) in glioblastomas in order to determine their prognostic impact among grade IV gliomas. Pilocytic astrocytomas were used as controls. Q-RT-PCR showed that transcripts of uPA, PAI-1, cathepsin B and MMP9 were significantly more expressed in glioblastomas (n = 52), in comparison to pilocytic astrocytomas (n = 17) (P = 0.049, P < 0....
Source: Acta Neuropathologica - September 23, 2009 Category: Neurology Tags: Acta Neuropathologica Source Type: journals

A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We have found that a secretory phospholipase (nPLA) purified from snake venom could reduce infarct volume in rodent stroke model. nPLA, has also been found to reduce neuronal cell death, apoptosis and promote cell survival in in-vitro ischemic conditions. In all conditions, the protective effects could be seen at sub-lethal concentrations of the protein. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - September 22, 2009 Category: Neuroscience Authors: Arunmozhiarasi ArmugamCharmian CherKaiYing LimDawn KohDavid HowellsKandiah Jeyaseelan Source Type: journals

Impact of Morphology, MIB-1, p53 and MGMT on Outcome in Pilocytic AstrocytomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pilocytic astrocytoma (PA) is the most common glioma in the pediatric population. PAs can exhibit variable behavior that does not always correlate with location, yet at present there is no way to predict which tumors will be more aggressive. To address this problem, an institutional cohort of 147 PAs (118 with outcome data) from both cerebellar and noncerebellar locations (spine, diencephalon, midbrain, brainstem and cortex) was utilized. Parameters included quantification of characteristic morphologic variables as well as genes previously shown to be of relevance in high-grade gliomas, including MIB-1, p53 and MGMT. In th...
Source: Brain Pathology - September 20, 2009 Category: Neurology Authors: Craig Horbinski, Ronald L. Hamilton, Colleen Lovell, Judith Burnham, Ian F. Pollack Source Type: journals

A phase II prospective study of sequential myeloablative chemotherapy with hematopoietic stem cell rescue for the treatment of selected high risk and recurrent central nervous system tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract High risk/recurrent CNS tumors have a poor prognosis. We studied tandem high dose chemotherapy (HDC) with hematopoietic progenitor stem cell rescues (HPCR) as potentially curative therapy. Twenty-four patients (mean age 6.8 years) were enrolled, 19 underwent HDC/HPCR. Diagnoses were medulloblastoma (n = 9), germ cell tumor (n = 4), high grade astrocytoma (n = 2), supratentorial PNET (n = 1), pineoblastoma (n = 2), or papillary meningioma (n = 1). Cytoreduction regimen #1 consisted of carboplatin (500 mg/m2) × 3 days,...
Source: Journal of Neuro-Oncology - September 20, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Involvement of aquaporin in thromboxane A(2) receptor-mediated, G(12/13)/RhoA/NHE-sensitive cell swelling in 1321 N1 human astrocytoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The physiological role of the thromboxane A(2) (TXA(2)) receptor expressed on glial cells remains unclear. We previously reported that 1321 N1 human astrocytoma cells pretreated with dibutyryl cyclic AMP (dbcAMP) became swollen in response to U46619, a TXA(2) analogue. In the present study, we examined the detailed mechanisms of TXA(2) receptor-mediated cell swelling in 1321 N1 cells. The cell swelling caused by U46619 was suppressed by expression of p115-RGS, an inhibitory peptide of Galpha(12/13) pathway and C3 toxin, an inhibitory protein for RhoA. The swelling was also inhibited by treatment with Y27632, a Rho kina...
Source: Cellular Signalling - September 18, 2009 Category: Cytology Authors: Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N Tags: Cell Signal Source Type: journals