The responsiveness of triaxial accelerometer measurement of gait ataxia is higher than that of the scale for the assessment and rating of ataxia in the early stages of spinocerebellar degeneration - Shirai S, Yabe I, Takahashi-Iwata I, Matsushima M, Ito YM, Takakusaki K, Sasaki H.
We reported previously that the average medial-lateral gait amplitude while walking on a straight path determined using triaxial accelerometers fixed on the middle of the upper back may be a quantitative and concise indicator for the severity of cerebellar... (Source: SafetyLit)
Source: SafetyLit - April 19, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
How Common Is Unintentional Cannabis Ingestion?
Discussion
“[Cannabis] is a genus of flowering plant with three main varieties: sativa, indica and ruderalis.” It has been used for hundreds of years for hemp or fiber and also for psychoactive and medicinal effects. The active compounds are collectively called cannabinoids, of which delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most abundant. The floral buds or calyxes of the plant have the most cannabinoids, but other parts of the plant are also used such as leaves. Hash oil, hashish (or resin) and marijuana (dried leaves) are the common products from strongest to least strongest products. ...
Source: PediatricEducation.org - March 11, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
C-Path, FARA launch Friedreich's Ataxia Clinical Database for Development of Treatments
(Critical Path Institute (C-Path)) C-Path's Data Collaboration Center and FARA announced the launch of the Friedreich's Ataxia Integrated Clinical Database. The platform will enable collaborative research and data sharing to support the understanding of natural history, biomarkers and clinical endpoints, and promote research into clinical trial design in Friedreich's ataxia. The organizations hope to enable the development of tools that will help design and interpret efficient clinical trials -- leading to effective treatments for FA as soon as possible. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 27, 2019 Category: International Medicine & Public Health Source Type: news
Delayed presentation of neck arteries dissection, caused by water slide activity - Alboudi AM, Sarathchandran P, Geblawi SS.
A 16-year-old Korean boy presented with acute onset vertigo, dysphagia and gait ataxia of 16 hours duration. He had history of headache and neck pain along with transient vertigo during a water slide ride 12 days before presentation. CT brain showed left... (Source: SafetyLit)
Source: SafetyLit - December 25, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Patient survival after acute voluntary poisoning with a huge dose of oxcarbazepine and olanzapine - Kalogera V, Galopoulos D, Eleftheriotis G, Meimeti E, Malios I, Marathonitis G, Loupa C.
INTRODUCTION: Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses... (Source: SafetyLit)
Source: SafetyLit - December 8, 2018 Category: International Medicine & Public Health Tags: Poisoning Source Type: news
What is the Recurrence Rate for Guillian-Barr é Syndrome and Should She Get An Influenza Vaccine?
Discussion
Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males.
GBS usually occurs 2-4 weeks after a prodromal gastroenteritis or respiratory illness. GBS causes autoantibody production against Schwann cells of the neuron and the axon itself. There is ...
Source: PediatricEducation.org - November 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
New study offers hope for patients suffering from a rare form of blindness
(Duke Department of Neurology) A new form of therapy may halt or even reverse a form of progressive vision loss that, until now, has inevitably led to blindness. This hyper-targeted approach offers hope to individuals living with spinocerebellar ataxia type 7 (SCA7) and validates a new form of therapy with the potential to treat neurogenetic diseases effectively and with far fewer side effects than other medications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 1, 2018 Category: International Medicine & Public Health Source Type: news
Finding that links ALS/ataxia to cellular stress opens new approaches for treatment
(University of Utah) Scientists at University of Utah Health report for the first time that a protein, called Staufen1, accumulates in cells of patients suffering from degenerative ataxia or amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Depleting the protein from affected mice improved symptoms including motor function. These results suggest that targeting Staufen1 could have therapeutic potential in people. The research is published in Nature Communications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news
An intrinsic S/G2 checkpoint enforced by ATR
The cell cycle is strictly ordered to ensure faithful genome duplication and chromosome segregation. Control mechanisms establish this order by dictating when a cell transitions from one phase to the next. Much is known about the control of the G1/S, G2/M, and metaphase/anaphase transitions, but thus far, no control mechanism has been identified for the S/G2 transition. Here we show that cells transactivate the mitotic gene network as they exit the S phase through a CDK1 (cyclin-dependent kinase 1)–directed FOXM1 phosphorylation switch. During normal DNA replication, the checkpoint kinase ATR (ataxia-telangiectasia a...
Source: ScienceNOW - August 23, 2018 Category: Science Authors: Saldivar, J. C., Hamperl, S., Bocek, M. J., Chung, M., Bass, T. E., Cisneros-Soberanis, F., Samejima, K., Xie, L., Paulson, J. R., Earnshaw, W. C., Cortez, D., Meyer, T., Cimprich, K. A. Tags: Cell Biology, Molecular Biology reports Source Type: news
Electrical Stimulation Helps Ataxia Symptoms (CME/CE)
(MedPage Today) -- Brain and spinal cord tDCS improved all performance scores in trial (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - August 22, 2018 Category: Neurology Source Type: news
Mechanism behind rare ataxia disease found by NIEHS scientists
NIEHS researchers reported how inactivation of a protein causes the rare disorder known as ataxia with oculomotor apraxia 1. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - August 2, 2018 Category: Environmental Health Source Type: news
An ATM that dispenses antioxidants
(Salk Institute) Research led by a Salk Institute professor along with collaborators from Yale, Appalachian State University and other institutions found that a protein called ATM (short for ataxia-telangiectasia mutated) can sense the presence of ROS and responds by sounding the alarm to trigger the production of antioxidants. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 10, 2018 Category: Biology Source Type: news
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Mitochondria are integral to cellular energy metabolism and ATP production and are involved in regulating many cellular processes. Mitochondria produce reactive oxygen species (ROS), which not only can damage cellular components but also participate in signal transduction. The kinase ATM, which is mutated in the neurodegenerative, autosomal recessive disease ataxia-telangiectasia (A-T), is a key player in the nuclear DNA damage response. However, ATM also performs a redox-sensing function mediated through formation of ROS-dependent disulfide-linked dimers. We found that mitochondria-derived hydrogen peroxide promoted ATM d...
Source: Signal Transduction Knowledge Environment - July 10, 2018 Category: Science Authors: Zhang, Y., Lee, J.-H., Paull, T. T., Gehrke, S., DAlessandro, A., Dou, Q., Gladyshev, V. N., Schroeder, E. A., Steyl, S. K., Christian, B. E., Shadel, G. S. Tags: STKE Research Articles Source Type: news
Gene silencing alleviates Machado-Joseph disease in study with mice
A gene-silencing technique was effective in slowing the progression of ataxia, according to a study with mice. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 20, 2018 Category: Consumer Health News Source Type: news
University of Michigan researchers use gene silencing to alleviate common ataxia
(Michigan Medicine - University of Michigan) In what researchers are calling a game changer for future ataxia treatments, a new study showed the ability to turn down the disease progression of the most common dominantly inherited ataxia, Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease. A single gene mutation causes this neurodegenerative disease, making it an ideal target for researchers. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 20, 2018 Category: Biology Source Type: news
