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Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
. Reijo Pera The leading cause of infertility in men and women is quantitative and qualitative defects in human germ-cell (oocyte and sperm) development. Yet, it has not been possible to examine the unique developmental genetics of human germ-cell formation and differentiation owing to inaccessibility of germ cells during fetal development. Although several studies have shown that germ cells can be differentiated from mouse and human embryonic stem cells, human germ cells differentiated in these studies generally did not develop beyond the earliest stages. Here we used a germ-cell reporter to quantify and isolate primordia...
Source: Nature AOP - October 28, 2009 Category: Research Authors: Kehkooi KeeVanessa T. AngelesMartha FloresHa Nam NguyenRenee A. Reijo Pera Tags: Letter Source Type: journals

Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
. Reijo Pera The leading cause of infertility in men and women is quantitative and qualitative defects in human germ-cell (oocyte and sperm) development. Yet, it has not been possible to examine the unique developmental genetics of human germ-cell formation and differentiation owing to inaccessibility of germ cells during fetal development. Although several studies have shown that germ cells can be differentiated from mouse and human embryonic stem cells, human germ cells differentiated in these studies generally did not develop beyond the earliest stages. Here we used a germ-cell reporter to quantify and isolate primordia...
Source: Nature - October 28, 2009 Category: Research Authors: Kehkooi KeeVanessa T. AngelesMartha FloresHa Nam NguyenRenee A. Reijo Pera Tags: Letter Source Type: journals

Mutations in the protamine locus: association with spermatogenic failure?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The protamine locus consists of a 28.5 kb region with a linear array of the protamine (PRM)1, PRM2, PRM3 and transition nuclear protein (TNP)2 genes. Several studies indicate an abnormal expression pattern of protamine genes associated with male infertility, although the molecular mechanism underlying this observation is unclear. Here, we determined the spectrum of DNA variants present in all four genes in men with unexplained infertility compared with an ancestry-matched fertile/normospermic population. A total of 160 control individuals and at least 125 infertile men with either idiopathic azoospermia or oligozoospermia ...
Source: Molecular Human Reproduction - October 15, 2009 Category: Molecular Biology Authors: Imken, L., Rouba, H., El Houate, B., Louanjli, N., Barakat, A., Chafik, A., McElreavey, K. Tags: Original Research Source Type: journals

Quick recovery and characterization of cell-free DNA in seminal plasma of normozoospermia and azoospermia: implications for non-invasive genetic utilities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We established a quick and reliable method for recovering cell-free seminal DNA (cfsDNA), by using the binding-washing-elution procedure on the DNA purification column. Low variations (below 15%) among the triplicate values of cfsDNA quantity verified the reproducibility of our cfsDNA recovery method. Similar cfsDNA yield and size distribution between seminal plasma acquired by filtration and centrifugation confirmed the presence of cfsDNA. To investigate the general characterization of cfsDNA, the quantitation and size distribution of cfsDNA from normozoospermic and azoospermic semen were analyzed by real-time PCR and...
Source: Asian Journal of Andrology - October 11, 2009 Category: Urology & Nephrology Authors: Li HG, Huang SY, Zhou H, Liao AH, Xiong CL Tags: Asian J Androl Source Type: journals

[ICSI with non-ejaculated sperm: What about children?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For men presenting azoospermia, the development of ICSI with epidydimal (MESA) or testicular (TESE) sperm, allowed them to father their own progeny. Little is known about the issue of these ICSI, in terms of efficiency and quality of the conceptus, and many controversies remain. Some studies emphasized that children born after Assisted Reproductive Technology (ART) with surgically sperm retrieved were at increased risk of birth defects. In this context, we proposed a retrospective analysis of pregnancy issues with non-ejaculated sperm. PMID: 19818669 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetr...
Source: Gynecologie, Obstetrique & Fertilite - October 6, 2009 Category: OBGYN Authors: Hafhouf E, Taar JP, Demouzon J, Tibi C, Lévy R Tags: Gynecol Obstet Fertil Source Type: journals

LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The PARP-2 gene might be associated with azoospermia by meiotic arrest in humans. Content Type Journal ArticleCategory ANDROLOGYDOI 10.1007/s10815-009-9347-1Authors Naoko Sakugawa, Asahikawa Medical College Department of Obstetrics and Gynecology Midorigaokahigashi2-1-1-1 Asahikawa Hokkaido JapanToshinobu Miyamoto, Asahikawa Medical College Department of Obstetrics and Gynecology Midorigaokahigashi2-1-1-1 Asahikawa Hokkaido JapanAkira Tsujimura, Osaka University Department of Urology, Graduate School of Medicine Suita JapanEitetsu Koh, Kanazawa University Graduate School of Medical Science De...
Source: Journal of Assisted Reproduction and Genetics - October 6, 2009 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: journals

Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and ERbeta proteins in the human testis. Testis tissue samples were obtained from 12 men undergoing orchiectomy as adjuvant treatment for prostate cancer, and were stained by immunohistochemistry for c-fos, phosphorylated c-fos and ER...
Source: Cancer Control - October 3, 2009 Category: Cancer & Oncology Authors: Araújo FC, Oliveira CA, Reis AB, Del Puerto HL, Martins AS, Reis FM Tags: Histol Histopathol Source Type: journals

The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is an association of polymorphisms C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility. Therefore, the MSH5 and MLH3 polymorphisms may be genetic determinants for human spermatogenesis impairment. PMID: 19808033 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - October 2, 2009 Category: Chemistry Authors: Xu K, Lu T, Zhou H, Bai L, Xiang Y Tags: Clin Chim Acta Source Type: journals

Birth of a healthy male infant after transfer of vitrified-warmed blastocysts derived from intracytoplasmic sperm injection with vitrified-warmed oocytes and frozen-thawed spermatozoaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This is a rare case of a successful birth using a vitrified-warmed blastocyst grown after ICSI with a vitrified-warmed oocyte and frozen-thawed sperm. Content Type Journal ArticleCategory CRYOPRESERVATIONDOI 10.1007/s10815-009-9338-2Authors Koichi Kyono, Mitsui-Seimei Kyono ART Clinic Sendai Honcho Bl, 3F, 1-1-1, Honcho, Aobaku Sendai 980-0014 JapanYukiko Nakajo, Mitsui-Seimei Kyono ART Clinic Sendai Honcho Bl, 3F, 1-1-1, Honcho, Aobaku Sendai 980-0014 JapanMasakazu Doshida, Mitsui-Seimei Kyono ART Clinic Sendai Honcho Bl, 3F, 1-1-1, Honcho, Aobaku Sendai 980-0014 JapanMayumi Toya, Mitsui-S...
Source: Journal of Assisted Reproduction and Genetics - September 17, 2009 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: journals

Y chromosome gr/gr deletions are a risk factor for low semen qualityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION Y chromosome gr/gr deletions significantly reduce sperm counts and are thus associated with low semen quality. (Source: Human Reproduction)
Source: Human Reproduction - September 13, 2009 Category: Reproduction Medicine Authors: Visser, L., Westerveld, G.H., Korver, C.M., van Daalen, S.K.M., Hovingh, S.E., Rozen, S., van der Veen, F., Repping, S. Tags: Reproductive genetics Source Type: journals

Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the frequency and type of both chromosomal abnormalities and Y chromosome microdeletions in 90 patients with severe male factor infertility and 75 fertile control men. Thirty of the infertile patients had nonobstructive azoospermia, 30 had oligozoospermia and 30 had normozoospermia. Five of 30 were azoospermic, four of 30 were oligozoospermic and two of 30 were normozoospermic with Y chromosome microdeletions. The AZFc locus was the most frequently deleted region (64%). Ten cases with azoospermia, four cases with oligozoospermia and four cases with normozoospermia had chromosomal abnormalities. The 75 men with ...
Source: Genetics and Molecular Research - September 6, 2009 Category: Genetics & Stem Cells Authors: Ceylan GG, Ceylan C, Elyas H Tags: Genet Mol Res Source Type: journals

Beneficial effect of chlorambucil in steroid-dependent and cyclophosphamide-resistant minimal change nephrotic syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest a superior effect of chlorambucil over cyclophosphamide in steroid-dependent and cyclophosphamide-resistant children with MCNS. A future randomized controlled clinical trial is required to confirm our findings. PMID: 19809993 [PubMed - in process] (Source: Journal of Nephrology)
Source: Journal of Nephrology - August 31, 2009 Category: Urology & Nephrology Authors: Ueda N, Takahashi K, Akioka Y, Morooka M, Ogawa A, Tsuzuki K Tags: J Nephrol Source Type: journals

'Value of FSH and inhibin-B measurements in the diagnosis of azoospermia'– A clinician's overviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Azoospermia can be either of obstructive ctiology or due to the testis' failure to initiate or maintain spermatogenesis. FSH acts through its receptor at Sertoli cell level and modulates spermatogenesis initiation and maintenance. Inhibin B is a Sertoli cell product expressing the functional capacity of the cell and in an indirect way the state of seminiferous tubule activity. Both FSH and inhibin B differentiate clearly testicular from extra-testicular pathology of azoospermia while, none of these hormones has been convincingly established as predictory index for the finding of spermatozoa in TESE. (Source: International ...
Source: International Journal of Andrology - August 24, 2009 Category: Sexual Medicine Authors: D. A. Adamopoulos, E. G. Koukkou Source Type: journals

Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniques - ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Hadassah Hebrew University Hospital, Mt. Scopus, Jerusalem. (Source: UroToday)
Source: UroToday - August 23, 2009 Category: Urology & Nephrology Tags: Browse Categories - Pediatric Urology Source Type: info

'Value of FSH and inhibin-B measurements in the diagnosis of azoospermia'- A clinician's overview.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Azoospermia can be either of obstructive ctiology or due to the testis' failure to initiate or maintain spermatogenesis. FSH acts through its receptor at Sertoli cell level and modulates spermatogenesis initiation and maintenance. Inhibin B is a Sertoli cell product expressing the functional capacity of the cell and in an indirect way the state of seminiferous tubule activity. Both FSH and inhibin B differentiate clearly testicular from extra-testicular pathology of azoospermia while, none of these hormones has been convincingly established as predictory index for the finding of spermatozoa in TESE. PMID: 1...
Source: International Journal of Andrology - August 23, 2009 Category: Urology & Nephrology Authors: Adamopoulos DA, Koukkou EG Tags: Int J Androl Source Type: journals

Supernumerary marker chromosome 15 in a male with azoospermia and open bite deformity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Supernumerary marker chromosome 15 (sSMC[15]) is the most frequent marker chromosome, and it is generally regarded as unimportant if it does not contain the Prader-Willi/Angelman syndrome critical region (PWACR). The clinical importance of the larger markers in association with the critical region is mentioned in almost all reports related to marker chromosome 15, and smaller markers are solely associated with minor dysmorphic features, azoospermia and recurrent miscarriages. However, these small sSMC(15)s without the PWACR may also determine a specific phenotype. A dysmorphic examination of an azoospermic patient in a...
Source: Asian Journal of Andrology - August 23, 2009 Category: Urology & Nephrology Authors: Koç A, Onur SO, Ergün MA, Perçin EF Tags: Asian J Androl Source Type: journals

Diagnostic of infertility—immunological laboratory markersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
How to examine immunological factors of male and female infertility in routine clinical immunological laboratories? Proposed algorithms in clinical reproductive immunology—Male: Child (yes) (in the case of patients with long-term interval from the last delivery follow the childless patients guidelines). Childless: spermiogram 2 times with in 7 days—normal results: MAR test direct-positive-probable cause of infertility→anti sperm Ab in serum, MAR test direct negative→activation markers of NK cells+detection MIF (sperm)+aTTG+anti endomysium Ab+diagnostic of systemic diseases+acrosomal proteins. Abnormal result: agglu...
Source: Journal of Reproductive Immunology - August 18, 2009 Category: Allergy & Immunology Authors: M. Drahosova, J. Madar, I. Janatkova, K. Jankovicova Tags: 7th European Congress on Reproductive Immunology Source Type: journals

Serum Hormones in Patients With Nonobstructive Azoospermia After Microdissection Testicular Sperm ExtractionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hormonal followup after microdissection testicular sperm extraction is recommended, particularly in patients with Klinefelter's syndrome, to prevent the deleterious consequences of hypogonadism. (Source: The Journal of Urology)
Source: The Journal of Urology - August 16, 2009 Category: Urology & Nephrology Authors: Tomomoto Ishikawa, Kohei Yamaguchi, Koji Chiba, Atsushi Takenaka, Masato Fujisawa Tags: Sexual Function/Infertility Source Type: journals

Sperm Retrieval and Intracytoplasmic Sperm Injection in Men With Nonobstructive Azoospermia, and Treated and Untreated VaricoceleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that varicocele repair significantly increased the sperm retrieval rate in patients with clinical varicocele and nonobstructive azoospermia. (Source: The Journal of Urology)
Source: The Journal of Urology - August 16, 2009 Category: Urology & Nephrology Authors: Kubilay Inci, Metin Hascicek, Onder Kara, Ayse Veyhurda Dikmen, Timur Gürgan, Ali Ergen Tags: Sexual Function/Infertility Source Type: journals

MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS These results indicate that hyper-methylation in testis DNA from NOA patients is specific and not due a general methylation defect, and suggest that epigenetic silencing of MTHFR could play a role in azoospermic infertility. (Source: Human Reproduction)
Source: Human Reproduction - August 13, 2009 Category: Reproduction Medicine Authors: Khazamipour, N., Noruzinia, M., Fatehmanesh, P., Keyhanee, M., Pujol, P. Tags: Reproductive genetics Source Type: journals

Estrogen receptors alpha and beta in human testis: both isoforms are expressed.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates ERalpha mRNA expression in human testis and describes its localization in somatic and germ cell subtypes. These findings suggest that both ER isoforms are involved in the control of testicular function. PMID: 19886769 [PubMed - in process] (Source: Systems Biology in Reproductive Medicine)
Source: Systems Biology in Reproductive Medicine - August 1, 2009 Category: Reproduction Medicine Authors: Cavaco JE, Laurentino SS, Barros A, Sousa M, Socorro S Tags: Syst Biol Reprod Med Source Type: journals

Mutations of the cyclin A1 gene are not a common cause of male infertility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyclin A1 is essential for meiosis as shown by its essential role in mouse spermatogenesis, suggesting that changes in the gene may also alter male fertility in humans. In the present study, we performed a mutation screening of the cyclin A1 gene in order to investigate the possible association between the mutations of the gene and human impaired spermatogenesis using denaturing high performance liquid chromatography (DHPLC) in 347 infertile patients with azoospermia or severe oligozoospermia and 210 fertile controls. Four point mutations, c.321T>C, IVS3 +32G>C, IVS5+38A>G and c.1158G>A, were identified, bu...
Source: Systems Biology in Reproductive Medicine - August 1, 2009 Category: Reproduction Medicine Authors: Zhoucun A, Zhang S, Yang Y Tags: Syst Biol Reprod Med Source Type: journals

Optical coherence tomography: a novel modality for scrotal imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: We illustrate the usefulness of optical coherence tomography in the setting of testicular biopsy and the management of nonobstructive azoospermia. PMID: 19672447 [PubMed - as supplied by publisher] (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - July 31, 2009 Category: Urology & Nephrology Authors: Davis C, Kuang W Tags: Can Urol Assoc J Source Type: journals

PrefaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vasectomy is a safe and effective method of contraception that should be viewed as permanent. In the United States, it is employed by nearly 11% of all married couples and is performed on approximately one-half million men each year. Thus, vasectomies are carried out more often than any other urologic surgical procedure. Worldwide, however, far fewer vasectomies are performed than female sterilizations by tubal ligation, even though vasectomy is less expensive and is associated with less morbidity and mortality than tubal ligation. This apparent underutilization of a safe procedure is caused, in part, by concerns of men an...
Source: Neurologic Clinics - July 30, 2009 Category: Neurology Authors: Jay I. Sandlow, Harris M. Nagler Source Type: journals

Effects of Chloroformic Extracts from Washed and Unwashed Papaya Seeds (Carica papaya) on the Sperm Concentration of DogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Papaya seeds (Carica papaya Linn) have been found to have a significant effect on sperm characteristics in some mammals, including humans, but no studies have investigated the effects on dogs. In the present study, a significant decrease in sperm concentration was observed in a group of dogs treated with extracts from washed papaya seeds, but no decrease was observed in the group of dogs treated with non-washed seeds. An important effect of extract components from washed seeds such as fatty acids is probably involved in the reduction of sperm production because of Sertoli cell damage, as has been suggested for langur monke...
Source: Reproduction in Domestic Animals - July 23, 2009 Category: Reproduction Medicine Authors: A Ortega-Pacheco, M Jiménez-Coello, E Gutiérrez-Blanco, KY Acosta-Viana, E Guzmán-Marín, MA Zavala-Sánchez, NE Montalvo-Beltrán, MS Pérez-Gutiérrez Source Type: journals

Successful Fertility Treatment for Klinefelter's SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Microdissection testicular sperm extraction is an effective sperm retrieval technique in men with Klinefelter's syndrome. Men with hypogonadism who respond to medical therapy may have a better chance of sperm retrieval. (Source: The Journal of Urology)
Source: The Journal of Urology - July 20, 2009 Category: Urology & Nephrology Authors: Ranjith Ramasamy, Joseph A. Ricci, Gianpiero D. Palermo, Lucinda Veeck Gosden, Zev Rosenwaks, Peter N. Schlegel Tags: Sexual Function/Infertility Source Type: journals

Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniquesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aetiology of cryptorchidism is still undiscernible in the majority of cases. It has long been argued that cryptorchidism reflects a primary testicular maldevelopment, where the contralateral scrotal testis also suffers from aspermatogenesis and low spermatogonia count. The aim of the study was to determine the reproductive outcome of ex-cryptorchid men with azoospermia post-orchidopexy after testicular sperm extraction (TESE) and intracytoplasmatic sperm injection (ICSI). In a retrospective analysis, we compared the sperm retrieval, fertilization, pregnancy and live birth rates after ICSI of consecutive ex-cryptorchid ...
Source: International Journal of Andrology - July 19, 2009 Category: Sexual Medicine Authors: R. Haimov-Kochman, D. Prus, M. Farchat, Y. Bdolah, A. Hurwitz Source Type: journals

Reproductive outcome of men with azoospermia due to cryptorchidism using assisted techniques.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aetiology of cryptorchidism is still undiscernible in the majority of cases. It has long been argued that cryptorchidism reflects a primary testicular maldevelopment, where the contralateral scrotal testis also suffers from aspermatogenesis and low spermatogonia count. The aim of the study was to determine the reproductive outcome of ex-cryptorchid men with azoospermia post-orchidopexy after testicular sperm extraction (TESE) and intracytoplasmatic sperm injection (ICSI). In a retrospective analysis, we compared the sperm retrieval, fertilization, pregnancy and live birth rates after ICSI of consecutive ex-cryptorc...
Source: International Journal of Andrology - July 19, 2009 Category: Urology & Nephrology Authors: Haimov-Kochman R, Prus D, Farchat M, Bdolah Y, Hurwitz A Tags: Int J Androl Source Type: journals

Expansion of CAG repeats in the spinocerebellar ataxia type 1 (SCA1) gene in idiopathic oligozoospermia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions SCA1 in a subset of oligozoospermia patients has an increased number of CAG repeats. Content Type Journal ArticleCategory GENETICSDOI 10.1007/s10815-009-9325-7Authors Yen-Chein Lai, Chung Shan Medical University School of Medical Laboratory and Biotechnology Taichung TaiwanWen-Chung Wang, Jen-Ai Hospital Department of Obstetrics and Gynecology Taichung TaiwanJiann-Jou Yang, Chung Shan Medical University Department of Biomedical Sciences No.110, Sec. 1, Chien Kuo N. Road Taichung 402 TaiwanShuan-Yow Li, Chung Shan Medical University Department of Biomedical Sciences No.110, Sec. 1, Chien Ku...
Source: Journal of Assisted Reproduction and Genetics - July 14, 2009 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: journals

Functional polymorphism in H2BFWT -5'UTR is associated with susceptibility to male infertility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract H2B histone family, member W, testis-specific (H2BFWT) gene encodes a testis-specific histone that becomes incorporated into sperm chromatin. A male infertility-associated single nucleotide polymorphism (-9C>T) within the 5'untranslated region (5'UTR) of the H2BFWT gene was identified by direct sequencing. Statistical association studies showed the polymorphism significantly associated with male infertility (n=442, p=0.0157), specially in non-azoospermia (n=262, p=0.018). Furthermore, this polymorphism is also associated with sperm parameters, especially sperm count (n=164, p=0.0127) and vitality (n=164, p=...
Source: J Cell Mol Med - July 5, 2009 Category: Molecular Biology Authors: Lee J, Park HS, Kim HH, Yun YJ, Lee DR, Lee S Tags: J Cell Mol Med Source Type: journals

Polyorchidism in a patient with azoospermia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19587516 [PubMed - in process] (Source: Saudi Journal of Kidney Diseases and Transplantation)
Source: Saudi Journal of Kidney Diseases and Transplantation - June 30, 2009 Category: Urology & Nephrology Authors: Ahmadnia H, Molaei M Tags: Saudi J Kidney Dis Transpl Source Type: journals

Varicocelectomy in men with nonobstructive azoospermia: Is it beneficial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High ligation varicocelectomy may offer nonobstructive azoospermic men an opportunity to have motile sperm via ejaculate and even the chance of natural conception, instead of the more bothersome assisted reproductive techniques. (Source: International Journal of Surgery)
Source: International Journal of Surgery - June 18, 2009 Category: Surgery Authors: Tamer Youssef, Ebraheim Abd-Elaal, Ghada Gaballah, Samir Elhanbly, Ebraheim Eldosoky Tags: Original Research Source Type: journals

Use of the aromatase inhibitor letrozole to treat male infertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): This is the first case report on the use of letrozole to treat male infertility and the first case report on the induction of spermatogenesis in a man with NOA using any aromatase inhibitor. (Source: Fertility and Sterility)
Source: Fertility and Sterility - June 11, 2009 Category: Reproduction Medicine Authors: Geneviève Patry, Keith Jarvi, Ethan D. Grober, Kirk C. Lo Tags: Case report summaries Source Type: journals

Evaluation of breast enlargement in young males and factors associated with gynecomastia and pseudogynecomastiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We concluded that gynaecomastia in young adult males is mostly because of KS or idiopathic in origin. IG seems to be the result of androgen resistance and in part increased aromatization because of increased adiposity. Symptoms or findings for hypogonadism must be evaluated carefully in patients with pseudogynecomastia. We also suggest that the presence of both gynecomastia and azoospermia necessitate further karyotypic analyses for KS. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11845-009-0345-1Authors M. Yazici, Gulhane University Department of Endocrinology and...
Source: Irish Journal of Medical Science - June 4, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

A single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that SPATA17 may play a critical role in human spermatogenesis, especially in meiosis.Asian Journal of Andrology advance online publication. 1 June 2009; doi: 10.1038/aja.2009.30. PMID: 19483714 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - May 31, 2009 Category: Urology & Nephrology Authors: Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Sakugawa N, Miyakawa H, Sato H, Namiki M, Okuyama A, Sengoku K Tags: Asian J Androl Source Type: journals

Re: Value of Serum Antisperm Antibodies in Diagnosing Obstructive AzoospermiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lee R, Goldstein M, Ullery BW, et al.J Urol 2009;181:264–9Experts’ summary:The authors evaluated the diagnostic accuracy of the presence of antisperm antibodies (ASA) in serum to identify patients with obstructive azoospermia. A series of 484 infertile men with different etiologies underwent a clinical evaluation and measurement of ASA (immunoglobulin [Ig] G, IgA, IgM) in serum using indirect immunobead assay. Two possible outcomes were considered for ASA detection: negative (0% binding) and positive (>0% binding). Of the 484 patients recruited for the study, 272 had documented obstruction of the deferent duct (all had...
Source: European Urology - May 31, 2009 Category: Urology & Nephrology Authors: Marcelo Marconi, Wolfgang Weidner Tags: Words of Wisdom Source Type: journals

Mutations in the TSPYL1 gene associated with 46,XY disorder of sex development and male infertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We screened 100 individuals with anomalies of testicular development or function for mutations in the TSPYL1 gene. A 46,XY female with complete gonadal dysgenesis carried a p.K320R mutation in the highly conserved NAP domain, and a 46,XY male with idiopathic azoospermia harbored a p.R89H mutation, and this data supports the hypothesis that mutations in TSPYL1 may contribute to anomalies of testicular development/function. (Source: Fertility and Sterility)
Source: Fertility and Sterility - May 20, 2009 Category: Reproduction Medicine Authors: Giovanna Vinci, Raja Brauner, Attila Tar, Hassan Rouba, Jayesh Sheth, Frenny Sheth, Celia Ravel, Ken McElreavey, Anu Bashamboo Tags: Male factor Source Type: journals

Is this really a breakthrough in male contraception?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Men will not be falling over themselves to have monthly testosterone injections in a tender part of their anatomy. Fortunately a more acceptable form of male contraception is in the pipelineIf you're a heterosexual man in a long-term relationship but would rather not hear the patter of tiny feet just yet, would you willingly submit to a monthly contraceptive jab in the buttocks?The front page of yesterday's Daily Express trumpeted the development of a "male pill" – a hormone injection that renders men temporarily infertile and is "as effective as the female pill in preventing pregnancy". The story reported a phase III cl...
Source: Guardian Unlimited Science - May 6, 2009 Category: Science Tags: Science Reproduction Society Health Medical research Life and style & wellbeing guardian.co.uk Blogposts Source Type: news

Micro-TESE appears effective for preserving fertility in cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microdissection testicular sperm extraction (micro-TESE) appears to be an effective method for preserving fertility in men with cancer who have azoospermia at the time of their cancer diagnosis. (Source: Modern Medicine)
Source: Modern Medicine - April 30, 2009 Category: Journals (General) Source Type: info

Obstructive Azoospermia: A Microsurgical Success Story - AbstractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Massachusetts General Hospital, MGH Fertility Center, Boston, Massachusetts 02114, USA. (Source: UroToday)
Source: UroToday - April 20, 2009 Category: Urology & Nephrology Tags: Browse Categories - Male Infertility & Reproduction Source Type: info

Identification of Potentially Damaging Amino Acid Substitutions Leading to Human Male Infertility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are a number of known genetic alterations found in men with non-obstructive azoospermia, or testicular failure, such as Y-microdeletions and cytogenetic abnormalities. However, the etiology of non-obstructive azoospermia is unknown in the majority of men. The aim of this study was to investigate the possibility that unexplained cases of non-obstructive azoospermia are caused by non-synonymous Single Nucleotide Polymorphisms (SNPs) in the coding regions of autosomal genes associated with sperm production and fertility. Using a candidate gene approach based on genetics of male infertility in mice, we re-sequenced n...
Source: Biology of Reproduction - April 14, 2009 Category: Reproduction Medicine Authors: Kuzmin A, Jarvi K, Lo K, Spencer L, Chow GY, Macleod G, Wang Q, Varmuza S Tags: Biol Reprod Source Type: journals

Controversies in the management of nonobstructive azoospermiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article analyzes two competing approaches to these patients: noninvasive and invasive. The noninvasive approach, based on clinical, laboratory, and ultrasonographic investigations, excludes from IVF/ICSI a significant number of patients owing to errors in predicting the presence of sufficient intratesticular spermatozoa. The invasive approach, with available percutaneous or surgical testicular biopsy techniques followed by morphologic examination and or sperm recovery, permits many patients with NOA to receive a favorable prognosis and therapeutic trial. However, the available testicular biopsy techniques are so varia...
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Angelo Carpi, Edmund Sabanegh, Jeffrey Mechanick Tags: Modern trends Source Type: journals

Sequence alterations in the YBX2 gene are associated with male factor infertilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): These data indicate a significant association between gene alterations in the YBX2 gene and abnormal spermatogenesis in humans, including a potential role in altering protamine expression, and implicate YBX2 gene alterations as a potential cause of male factor infertility. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Sue Hammoud, Benjamin R. Emery, Diane Dunn, Robert B. Weiss, Douglas T. Carrell Tags: Male factor Source Type: journals

Consanguinity and family clustering of male factor infertility in LebanonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Consanguineous marriage is a socially supported institution throughout the Muslim world, yet its relationship to infertility is poorly understood. This study demonstrated a significant association between consanguinity and family clustering of male factor infertility cases, suggesting a strong genetic component. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Marcia C. Inhorn, Loulou Kobeissi, Zaher Nassar, Da'ad Lakkis, Michael H. Fakih Tags: Male factor Source Type: journals

Serum inhibin B and anti-Müllerian hormone are not superior to follicle-stimulating hormone as predictors of the presence of sperm in testicular fine-needle aspiration in men with azoospermiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion(s): Serum INHB and AMH, as well as their combination, are not superior to FSH as predictors of the presence of sperm in testicular FNA in men with azoospermia and should not be used for this purpose. (Source: Fertility and Sterility)
Source: Fertility and Sterility - April 1, 2009 Category: Reproduction Medicine Authors: Dimitrios G. Goulis, Christos Tsametis, Paschalia K. Iliadou, Paris Polychronou, Persefoni-Dimitra Kantartzi, Basil C. Tarlatzis, Ioannis N. Bontis, Ioannis Papadimas Tags: Techniques and instrumentation Source Type: journals

Male gonadal toxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer treatment with chemotherapy or radiotherapy causes gonadal toxicity in male patients. The endpoint of most concern for future reproductive options is the induction of prolonged azoospermia, which may or may not be reversible. The immediate effects of therapy and its reversibility are most readily observed in post-pubertal patients, but the same antineoplastic regimens given to prepubertal males can induce permanent azoospermia. The probability of permanent azoospermia is related to the specific agents used and their doses. The most damaging are alkylating agents (particularly chlorambucil, procarbazine, cyclophospha...
Source: Pediatric Blood and Cancer - March 26, 2009 Category: Cancer & Oncology Authors: Marvin L. Meistrich Source Type: journals

The role of ultrasound in assessment of male fertility.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ultrasonography (US) is a widely used and well tolerated imaging modality for evaluation of pathologic conditions of the testes. Recent technical advances of US applications and post processing developments have enabled new aspects in the structural and functional analysis of testicular tissue and therefore male fertility. This review covers the most relevant approaches due to recent technical advances. Testicular volume measured by B-mode US correlated significantly with testicular function. Increased resistive index (RI) and pulsatility index (PI) of capsular branches of testicular arteries on unenhanced color Dopple...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 19, 2009 Category: OBGYN Authors: Schurich M, Aigner F, Frauscher F, Pallwein L Tags: Eur J Obstet Gynecol Reprod Biol Source Type: journals

Hypergonadotropic Hypogonadism in Spinocerebellar Ataxia Type 2: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. The present study suggests that a common genetic implication may be shared between these neurologic and non-neurologic signs, and there may be various associations between these heterogeneous manifestations. The clinical spectrum of the SCA2 should be widened, and further data collection is needed to elucidate the relationship among the clinical manifestations. Kwon D-Y, and Park MH. Hypergonadotropic hypogonadism in spinocerebellar ataxia type 2: A case report. J Sex Med **;**:**[ndash]**. (Source: The Journal of Sexual Medicine)
Source: The Journal of Sexual Medicine - March 18, 2009 Category: Sexual Medicine Authors: Do-Young Kwon, Moon Ho Park Source Type: journals

Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel gene, TSG23/Tsg23, was identified by comparing the expression profiles of human adult and fetal testis using Affymetrix Genechips. RT–PCR analysis from multiple human and mouse tissues indicated TSG23/Tsg23 mRNA was mainly expressed in the testis. In situ hybridization revealed that TSG23/Tsg23 mRNA was located in spermatocytes and round spermatids of the seminiferous tubules in human and mouse testis. To further confirm the result from RT–PCR, the antibody for human TSG23 was generated against the protein encoded by the gene. Western blot analysis demonstrated that TSG23 was mainly expressed in human t...
Source: Molecular Human Reproduction - March 18, 2009 Category: Molecular Biology Authors: Zhou, Y., Qin, D., Tang, A., Zhou, D., Qin, J., Yan, B., Diao, R., Jiang, Z., Cai, Z., Gui, Y. Tags: Articles Source Type: journals

Multicenter Contraceptive Efficacy Trial of Injectable Testosterone Undecanoate in Chinese Men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Monthly injection of 500 mg TU provides safe, effective, reversible and reliable contraception in a high proportion of healthy fertile Chinese men. PMID: 19293262 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 17, 2009 Category: Endocrinology Authors: Gu Y, Liang X, Wu W, Liu M, Song S, Cheng L, Bo L, Xiong C, Wang X, Liu X, Peng L, Yao K Tags: J Clin Endocrinol Metab Source Type: journals