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Carvedilol shown to have unique characteristics among beta blockersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(University of Illinois at Urbana-Champaign) In a new study, researchers report that a class of heart medications called beta-blockers can have a helpful, or harmful, effect on the heart, depending on their molecular activity. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 20, 2009 Category: Biology Source Type: news

New osteoporosis risk scores highly effectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Algorithms effectively predict osteoporotic risk and hip fractureRelated items from OnMedicaBooklet cuts antibiotic use for respiratory infectionsLarge rise in women having cervical screeningPolyclinics will destroy patient trust, warns studyPatient care improves in ScotlandGPs not prescribing enough beta blockers (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 20, 2009 Category: UK Health Source Type: news

Appropriate Evaluation and Treatment of Heart Failure Patients After Implantable Cardioverter-Defibrillator Discharge: Time to Go Beyond the Initial ShockEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiple clinical trials support the use of implantable cardioverter-defibrillators (ICDs) for prevention of sudden cardiac death in patients with heart failure (HF). Unfortunately, several complicating issues have arisen from the universal use of ICDs in HF patients. An estimated 20% to 35% of HF patients who receive an ICD for primary prevention will experience an appropriate shock within 1 to 3 years of implant, and one-third of patients will experience an inappropriate shock. An ICD shock is associated with a 2- to 5-fold increase in mortality, with the most common cause being progressive HF. The median time from initi...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Joseph D. Mishkin, Sherry J. Saxonhouse, Gregory W. Woo, Thomas A. Burkart, William M. Miles, Jamie B. Conti, Richard S. Schofield, Samuel F. Sears, Juan M. Aranda Tags: State-of-the-Art Paper Source Type: journals

Commentary: Reconsidering the role for digoxin in the management of acute heart failure syndromesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: JAMA Area: News This Commentary article in JAMA discusses how the use of digoxin in the treatment of patients with chronic heart failure has decreased considerably, and argues that it is time to 'remember a forgotten drug'. Digoxin was licensed for this use based on the results of the Digitalis Investigation Group trial, which found that it reduced hospitalisations when added to standard therapy (diuretics and ACE inhibitors), although there was no effect on survival. Available data suggest that digoxin use has decreased considerably in the last 10 years; the author postulates several factor...
Source: NeLM - Cardiovascular Medicine - November 18, 2009 Category: Cardiology Source Type: organizations

Health Care Services Provided During Physician Office Visits for Hypertension: Differences by SpecialtyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to compare differences by physician specialty in the provision of health care services during office visits for hypertension. The authors examined office visits for US physicians by using data from the National Ambulatory Medical Care Survey for 2003 to 2005. Of more than 274 million hypertension visits, 35.5%, 43.9%, 8.5%, and 12.1% visits were made to general practitioners/family physicians, internists, cardiologists, and other specialties, respectively. Visitors to cardiologists were more likely to have coronary heart disease and heart failure than visitors to other physicians. While presc...
Source: The Journal of Clinical Hypertension - November 17, 2009 Category: Cardiology Authors: Jing Fang, Nora L. Keenan, Carma Ayala Source Type: journals

MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that the β-adrenergic pathway can stimulate expression of arrhythmogenic miR-1, contributing to ischaemic arrhythmogenesis, and β-blockers produce their beneficial effects partially by down-regulating miR-1, which might be a novel strategy for ischaemic cardioprotection. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Lu, Y., Zhang, Y., Shan, H., Pan, Z., Li, X., Li, B., Xu, C., Zhang, B., Zhang, F., Dong, D., Song, W., Qiao, G., Yang, B. Tags: ORIGINAL ARTICLES Source Type: journals

Procoralen 5mg, 7.5mg tablets (ivabradine) - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.1 (Therapeutic indications) - the indication has been updated and the indication of ivabradine in combination with beta-blockers has been added. Section 4.4 (Special warnings and precautions for use) - combination with calcium channel blockers. The paragraph Chronic heart failure has been updated Section 5.1 (Pharmacodynamic Properties) - Two paragraphs have been added, refer to SPC for full details. (Source: NeLM - Cardiovascular Medicine)
Source: NeLM - Cardiovascular Medicine - November 16, 2009 Category: Cardiology Source Type: organizations

Treatment disparities and effect on late mortality in patients with diabetes presenting with acute myocardial infarction: observations from the ACACIA registry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Patients with diabetes have a higher risk than non-diabetic patients of late mortality following an acute MI, yet receive fewer guideline-recommended medications and early invasive procedures. Increased application of proven pharmacotherapies and an early invasive management strategy in patients with diabetes presenting with ACS might improve their outcomes. STUDY PROTOCOL NUMBER (SANOFI-AVENTIS): PML-0051. PMID: 19912085 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - November 16, 2009 Category: Journals (General) Authors: Hung J, Brieger DB, Amerena JV, Coverdale SG, Rankin JM, Astley CM, Soman A, Chew DP Tags: Med J Aust Source Type: journals

Review: Cardioversion of atrial fibrillation and the use of antiarrhythmic drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Heart Area: News This review on the treatment of atrial fibrillation (AF) looks at the following: . Indications for cardioversion of AF . Anti-arrhythmic drugs used for cardioversion or prevention of AF recurrence (digoxin, beta-blockers, non-dihydropyridine calcium antagonists, quinidine, disopyramide, propafenone, procainamide, dofetilide, amiodarone, sotalol, flecainide, dronedarone) . Non-anti-arrhythmic agents . Optimal management of patients with AF requiring rhythm control The authors note that large RCTs have shown that a rhythm control strategy (using antiarrhythm...
Source: NeLM - Cardiovascular Medicine - November 12, 2009 Category: Cardiology Source Type: organizations

Clinical Review: Is the Perioperative Use of {beta}-Blockers Still Recommended? A Critical Review of Recent ControversiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The optimal role of β-adrenergic receptor blockade in the perioperative period remains unclear in patients at risk for cardiovascular events. Cardiovascular complications continue to be the most common cause of perioperative morbidity and mortality, and cardioprotective properties of β-blockers are widely recognized, yet the results of the clinical trials investigating the use of different β-blockers in the perioperative period are controversial. The discrepancy might be related to differences in the design of studies, use of different agents, administration by different routes, and continuation for differen...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - November 11, 2009 Category: Cardiology Authors: Domanski, D., Schwarz, E. R. Tags: Articles Source Type: journals

Compliance With the Treatment of Hypertension: The Potential of Combination TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J Clin Hypertens (Greenwich). Patient adherence to antihypertensive medication is vital to ensure the successful treatment of hypertension. Low levels of adherence to and persistence with prescribed therapy are major factors leading to the current poor rates of blood pressure control among patients with hypertension. There are many reasons for nonadherence to therapy including patient-, physician-, and therapy-related factors. Poor tolerability has a detrimental effect on adherence, therefore reducing the apparent effectiveness of agents with dose-dependent side effects. Various effective combination therapies are recommen...
Source: The Journal of Clinical Hypertension - November 9, 2009 Category: Cardiology Authors: Serap Erdine Source Type: journals

Heart Rate Predicts Outcomes in an Implantable Cardioverter-Defibrillator Population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions-In this ICD population, the mean intrinsic HR was strongly associated with outcomes. Clinical Trial Registration-http://www.clinicaltrials.gov. Identifier: NCT00148967. PMID: 19901194 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - November 9, 2009 Category: Cardiology Authors: Ahmadi-Kashani M, Kessler DJ, Day J, Bunch TJ, Stolen KQ, Brown S, Sbaity S, Olshansky B, Tags: Circulation Source Type: journals

Is Pretreatment with Beta-Blockers Beneficial in Patients with Acute Coronary Syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiology 2010;115:91-97 (DOI:10.1159/000256384) (Source: Karger Publishers)
Source: Karger Publishers - November 6, 2009 Category: Cancer & Oncology Source Type: journals

Helical prospective ECG-gating in cardiac computed tomography: radiation dose and image qualityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Helical prospective ECG-gating (pECG) may reduce radiation dose while maintaining the advantages of helical image acquisition for coronary computed tomography angiography (CCTA). Aim of this study was to evaluate helical pECG–gating in CCTA in regards to radiation dose and image quality. 86 patients undergoing 64-multislice CCTA were enrolled. pECG-gating was performed in patients with regular heart rates (HR) < 65 bpm; with the gating window set at 70–85% of the cardiac cycle. All patients received oral and some received additional IV beta-blockers to achieve HR < ...
Source: The International Journal of Cardiovascular Imaging - November 6, 2009 Category: Radiology Tags: The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging) Source Type: journals

Prognostic value of myocardial perfusion SPECT images in combination with the maximal heart rate at exercise testing in Japanese patients with suspected ischemic heart disease: a sub-analysis of J-ACCESSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The combination of SSS using Ex-SPECT and the maximal heart rate is a useful predictor of cardiac events in patients with suspected coronary artery disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-009-0315-8Authors Kenji Ueshima, Kyoto University Graduate School of Medicine EBM Research Center Yoshida-Konoecho, Sakyo-ku Kyoto 606-8501 JapanAkira Yamashina, Tokyo Medical University Second Department of Internal Medicine Tokyo JapanSatoru Usami, Kyoto University Graduate School of Medicine Department of Medicine and Clinical Science Kyoto JapanShinji Yasuno, Kyo...
Source: Annals of Nuclear Medicine - November 6, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This review concluded that the magnitude of heart rate reduction was statistically significantly associated with the survival benefit of beta-blockers in heart failure, but the dose of beta-blocker was not. The majority of the review process and the synthesis were well conducted. Despite the absence of a validity assessment, the conclusions appear likely to be reliable. [Included studies assessed metoprolol, carvedilol, bisoprolol, bucindolol, nebivolol and atenolol. ] CRD Commentary: The review question was clear and was supported by specific inclusio...
Source: NeLM - Disease Focused Reviews - November 6, 2009 Category: Internal Medicine Source Type: organizations

Preventing Heart Attacks During Surgery: Drugs Not FoolproofEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prescription of beta blockers to prevent heart attack during non-cardiac surgery does not prevent cardiac events in all cases, and can even be dangerous to some patients. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - November 5, 2009 Category: Consumer Health News Source Type: news

{beta}-Blocker Compliance, Mortality, and Reinfarction: Validation of Clinical Trial Association Using Insurer Claims DataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although randomized controlled trials show that long-term β-blocker use post acute myocardial infarction (AMI) reduces mortality and subsequent cardiovascular events, and that increased compliance lowers mortality, there is limited published research on the effects of long-term β-blocker compliance in observational community settings. The authors retrospectively study the effect of β -blocker compliance on mortality and repeat reinfarction using claims records from a major health insurer of all patients who were discharged alive after AMI between January 2003 and June 2004, covered by that health insurer&rsq...
Source: American Journal of Medical Quality - November 4, 2009 Category: Health Management Authors: Kleiner, S. A., Vogt, W. B., Gladowski, P., DeVries, A., Levin, G., Antonucci, C., Fong, J. Tags: Articles Source Type: journals

Dose dependent effect of statins on postoperative atrial fibrillation after cardiac surgery among patients treated with beta blockersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Among cardiac surgery patients treated with postoperative beta blockers Statin treatment reduces the incidence of postoperative AF when used at higher dosages (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - November 4, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Salima MithaniMuhammad AkbarDeborah JohnsonMichael KuskowskiKatherine AppleJana Bonawitz-ConlinHerbert WardRosemary KellyEdward McFallsHanna BloomfieldJian-Ming LiSelcuk Adabag Source Type: journals

US Updates Advice on Perioperative Beta-Blocker Use in Noncardiac SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A US update on the perioperative use of beta blockers for noncardiac surgery is, says the lead author, "similar" to recent European guidance on this issue. Heartwire (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 3, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

US updates advice on perioperative beta-blocker use in noncardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A US update on the perioperative use of beta blockers for noncardiac surgery is, says the lead author, "similar" to recent European guidance on this issue. (Source: theHeart.org)
Source: theHeart.org - November 3, 2009 Category: Cardiology Source Type: info

ACCF/AHA Issue Guidelines for Perioperative Use of Beta-BlockersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 3, 2009 Category: Primary Care Tags: Medical News Source Type: info

Revised Guidelines From ACC/AHA For The Perioperative Use Of Beta Blockers To Minimize Cardiac RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac complications around the time of noncardiac surgery are relatively common and can be serious. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

American College of Cardiology Foundation/American Heart Association focused update on peri-operative beta blockadeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Circulation Area: News The American College of Cardiology Foundation/American Heart Association have produced a focused update of the "ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Non-cardiac Surgery", addressing predominantly the prophylactic use of beta blockers peri-operatively to minimise cardiac risk. Please see the link below for access (free full text at time of publication). (Source: NeLM - News)
Source: NeLM - News - November 3, 2009 Category: Drugs & Pharmacology Source Type: organizations

[Response to oral propranolol therapy for ulcerated hemangiomas in infancy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of an 8-month-old girl with a voluminous ulcerated hemangioma of the left forearm with a large, painful, central ulceration. Conventional treatment with topical and/or systemic antibiotics was unsuccessful. Flashlamp-pumped pulsed-dye laser (FPDL) could not be used because of the thickness of the lesions. We decided to use beta-blocker therapy (propanolol) for 4 months with a noteworthy efficacy. DISCUSSION: Systemic corticosteroids and FPDL are currently the reference treatment of the superficial hemangioma during infancy, but the head and neck location or complications such as ulceration or the need fo...
Source: Archives de Pediatrie - November 3, 2009 Category: Pediatrics Authors: Michel JL, Patural H Tags: Arch Pediatr Source Type: journals

ACC/AHA Say Don't Start Beta-Blockers on Day of Surgery (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-risk patients who are not taking beta-blockers should have beta-blocker therapy started well before scheduled cardiovascular surgery, with doses titrated up as the surgery date approaches, according to updated guidelines released today by the American College of Cardiology and American Heart Association. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 2, 2009 Category: Cardiology Source Type: news

Perioperative Beta-Blocker Therapy Guidelines UpdatedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The American College of Cardiology Foundation/American Heart Association recommends perioperative beta-blocker use dependent on careful consideration of the benefits and risks to an individual patient, according to an update of the 2007 guidelines outlining cardiovascular evaluation and care for non-cardiac surgery published online Nov. 2 in the Journal of the American College of Cardiology. (Source: Modern Medicine)
Source: Modern Medicine - November 2, 2009 Category: Journals (General) Source Type: info

New guideline addresses beta blocker usage to lessen cardiac risk during surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The American College of Cardiology and the American Heart Association have released a Focused Update to the Practice Guidelines based on new clinical trial data on the risks and benefits of using beta blockers to reduce cardiac events during non-cardiac surgeries. It provides specific recommendations about which patients will likely benefit from beta blockers and in which patients there is not enough evidence to recommend their use. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - November 1, 2009 Category: Cardiology Tags: Latest News Source Type: news

Perioperative Beta-Blockade May Reduce Cardiac RisksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BARCELONA — Pre- and perioperative treatment with a beta-blocker is an important part of managing cardiac risk in selected patients undergoing noncardiac surgery, according to new guidelines from the European Society of Cardiology. (Source: Rheumatology News)
Source: Rheumatology News - November 1, 2009 Category: Rheumatology Authors: MITCHEL L. ZOLER Tags: Across Specialties Source Type: journals

Beta-Blockers May Cut Mortality in TBI PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PITTSBURGH — Beta-blockers may have a protective effect in patients with traumatic brain injury, significantly reducing mortality, based on a retrospective study of more than 2,000 patients. (Source: Clinical Neurology News)
Source: Clinical Neurology News - November 1, 2009 Category: Neurology Authors: KERRI WACHTER Tags: News Source Type: news

Beta-Blockers May Cut Mortality in Patients With TBIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PITTSBURGH — Beta-blockers may have a protective effect in patients with traumatic brain injury, significantly reducing mortality, based on a retrospective study of more than 2,000 patients. (Source: Clinical Psychiatry News)
Source: Clinical Psychiatry News - November 1, 2009 Category: Psychiatry Authors: KERRI WACHTER Tags: Neurology Source Type: journals

The effect of prostaglandin analogues on central corneal thickness of patients with chronic open-angle glaucoma: a 2-year study on 129 eyesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The possibility of corneal thickening under prolonged, local prostaglandin treatment should be investigated further. However, in clinical practice, CCT changes may sometimes influence intraocular pressure measurements significantly. (Source: Acta Ophthalmologica)
Source: Acta Ophthalmologica - October 30, 2009 Category: Opthalmology Authors: Maria Bafa, Gerasimos Georgopoulos, Constantinos Mihas, Panagiotis Stavrakas, Dimitrios Papaconstantinou, Ioannis Vergados Source Type: journals

Improving survival in the 6 months after diagnosis of heart failure in the past decade: population-based data from the UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although early mortality remains high among patients with newly diagnosed heart failure in the UK general population, there is strong evidence of a marked improvement in survival from 1995–7 to 2004–5, perhaps partly explained by an increased usage of neurohormonal antagonists. (Source: Heart)
Source: Heart - October 29, 2009 Category: Cardiology Authors: Mehta, P A, Dubrey, S W, McIntyre, H F, Walker, D M, Hardman, S M C, Sutton, G C, McDonagh, T A, Cowie, M. R Tags: Drugs: cardiovascular system, Epidemiology Original articles Source Type: journals

Therapeutic Management in Patients with Renal Failure who Experience an Acute Coronary Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest that in patients with ACS, the extent of undertreatment due to chronic kidney disease is less than reported previously, which is partially explained by more complete adjustment for cotreatments/comorbidities. PMID: 19875769 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 29, 2009 Category: Urology & Nephrology Authors: Cardinal H, Bogaty P, Madore F, Boyer L, Joseph L, Brophy JM Tags: Clin J Am Soc Nephrol Source Type: journals

Impact of Heart Rate Frequency and Variability on Radiation Exposure, Image Quality, and Diagnostic Performance in Dual-Source Spiral CT Coronary Angiography [Cardiac Imaging]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: DS spiral CT coronary angiography performed with adaptive ECG pulsing results in preserved diagnostic image quality and performance independent of HRF or HRV at the cost of limited dose reduction in arrhythmic patients. © RSNA, 2009 (Source: Continuous Publishing articles)
Source: Continuous Publishing articles - October 28, 2009 Category: Radiology Authors: Weustink, A. C., Neefjes, L. A., Kyrzopoulos, S., van Straten, M., Neoh Eu, R., Meijboom, W. B., van Mieghem, C. A., Capuano, E., Dijkshoorn, M. L., Cademartiri, F., Boersma, E., de Feyter, P. J., Krestin, G. P., Mollet, N. R. Tags: Cardiac Imaging Source Type: journals

Four Basics And Some Good Information About Beta-Blocker Treatment For High Blood PressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
If you're one of the millions of Americans taking a medicine called a beta-blocker for high blood pressure, here are some basics about this family of medicines: -- Beta-blockers are a family of medicines also known as beta-adrenergic blocking agents. When you take beta blockers, the heart beats more slowly and with less force, reducing blood pressure. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 28, 2009 Category: Consumer Health News Tags: Hypertension Source Type: news

Incremental benefits of raising high-density lipoprotein cholesterol during lipid therapy after adjustment for reductions in other lipid levelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Arch Internal Med Area: News According to research published in the Archives of Internal Medicine, raising HDL-C levels with commonly used lipid medications appears to be an important determinant of the benefits associated with lipid therapy. Researchers evaluated data from the Framingham Offspring Study from 1975 through 2003 to determine whether increases in HDL-C levels after lipid therapy was started were independently associated with a reduction in cardiovascular (CV) events. The independent effect of HDL-C levels on future CV risk (average follow-up, 8 years) was estimated after adjustment for chang...
Source: NeLM - Cardiovascular Medicine - October 28, 2009 Category: Cardiology Source Type: organizations

The challenge of analyzing beta-blocker drugs in sludge and wastewater.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, different approaches were used to assess and overcome the severe effects of interference from the sample matrix from different types of sludges and wastewater on the analysis of nine beta-blockers and the beta sympathomimetic clenbuterol. The partitioning of the target compounds into sludge was investigated in wastewater treatment plants (WWTPs) in both Canada and Germany to evaluate whether this is an important mechanism for removal from sewage. Due to ion suppression in the electro spray interface, absolute recoveries were for certain compounds even lower than 20%. By using surrogate standards, acceptable ...
Source: Analytical and Bioanalytical Chemistry - October 28, 2009 Category: Chemistry Authors: Scheurer M, Ramil M, Metcalfe CD, Groh S, Ternes TA Tags: Anal Bioanal Chem Source Type: journals

Impact of Heart Rate Frequency and Variability on Radiation Exposure, Image Quality, and Diagnostic Performance in Dual-Source Spiral CT Coronary Angiography.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: DS spiral CT coronary angiography performed with adaptive ECG pulsing results in preserved diagnostic image quality and performance independent of HRF or HRV at the cost of limited dose reduction in arrhythmic patients. (c) RSNA, 2009. PMID: 19864512 [PubMed - as supplied by publisher] (Source: Radiology)
Source: Radiology - October 28, 2009 Category: Radiology Authors: Weustink AC, Neefjes LA, Kyrzopoulos S, van Straten M, Neoh Eu R, Meijboom WB, van Mieghem CA, Capuano E, Dijkshoorn ML, Cademartiri F, Boersma E, de Feyter PJ, Krestin GP, Mollet NR Tags: Radiology Source Type: journals

Trial-generated profiles for implantation of electrical devices in outpatients with heart failure: real-world prevalence and 1-year outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions As many as half the IN-CHF outpatients fulfilled current criteria for device implantation. Various subgroups had higher 1-year mortality than patients in trial control arms [ndash] a finding that may not be entirely attributable to differences in drug therapy (especially beta blockers). (Source: Journal of Evaluation in Clinical Practice)
Source: Journal of Evaluation in Clinical Practice - October 27, 2009 Category: Journals (General) Authors: Giuseppe Boriani, Claudio Rapezzi, Igor Diemberger, Lucio Gonzini, Marco Gorini, Donata Lucci, Gianfranco Sinagra, Robin M. T. Cooke, Giuseppe Di Pasquale, Luigi Tavazzi, Aldo P. Maggioni Source Type: journals

Microvascular oxygen delivery-to-utilization mismatch at the onset of heavy-intensity exercise in optimally treated patients with CHFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Impaired muscle blood flow at the onset of heavy-intensity exercise may transiently reduce microvascular O2 pressure and decrease the rate of O2 transfer from capillary to mitochondria in chronic heart failure (CHF). However, advances in the pharmacological treatment of CHF (e.g., angiotensin-converting enzyme inhibitors and third-generation β-blockers) may have improved microvascular O2 delivery to an extent that intramyocyte metabolic inertia might become the main locus of limitation of O2 uptake (Vo2) kinetics. We assessed the rate of change of pulmonary Vo2 (Vo2p), (estimated) fractional O2 extraction in the vastu...
Source: AJP: Heart and Circulatory Physiology - October 26, 2009 Category: Cardiology Authors: Sperandio, P. A., Borghi-Silva, A., Barroco, A., Nery, L. E., Almeida, D. R., Neder, J. A. Tags: ARTICLES Source Type: journals

ORIGINAL INVESTIGATION: Evaluating the Incremental Benefits of Raising High-Density Lipoprotein Cholesterol Levels During Lipid Therapy After Adjustment for the Reductions in Other Blood Lipid LevelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Raising HDL-C levels with commonly used lipid medications appears to be an important determinant of the benefits associated with lipid therapy. These results support the further evaluation of therapies to raise HDL-C levels to prevent CV events. (Source: Archives of Internal Medicine)
Source: Archives of Internal Medicine - October 26, 2009 Category: Internal Medicine Authors: Grover, S. A., Kaouache, M., Joseph, L., Barter, P., Davignon, J. Tags: Nutritional and Metabolic Disorders, Lipids and Lipid Disorders, Cardiovascular System, Cardiovascular Disease/ Myocardial Infarction, Drug Therapy, Adverse Effects, Drug Therapy, Other Original Investigation Source Type: journals

Evaluating the Incremental Benefits of Raising High-Density Lipoprotein Cholesterol Levels During Lipid Therapy After Adjustment for the Reductions in Other Blood Lipid Levels [Original Investigation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Raising HDL-C levels with commonly used lipid medications appears to be an important determinant of the benefits associated with lipid therapy. These results support the further evaluation of therapies to raise HDL-C levels to prevent CV events. (Source: Archives of Internal Medicine)
Source: Archives of Internal Medicine - October 26, 2009 Category: Internal Medicine Authors: Grover, S. A., Kaouache, M., Joseph, L., Barter, P., Davignon, J. Tags: Nutritional and Metabolic Disorders, Lipids and Lipid Disorders, Cardiovascular System, Cardiovascular Disease/ Myocardial Infarction, Drug Therapy, Adverse Effects, Drug Therapy, Other Original Investigation Source Type: journals

Benefit of Perioperative Beta Blockers Confirmed in Large StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Perioperative beta blockers cut 1-year mortality by 50% in surgical patients with cardiovascular risk factors. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 23, 2009 Category: Consumer Health News Tags: Anesthesiology Source Type: news

Suboptimal management of severe menopausal symptoms by Nigerian Gynaecologists: a call for mandatory continuing medical education for physicians.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The result revealed that most Nigerian Gynaecologists prefer reassurance and anxiolytics for managing severe menopausal symptoms instead of evidence-based effective therapies. A policy of mandatory continuing medical education for Nigerian physicians is recommended to ensure evidence-based management of gynaecological problems, including menopause. (Source: BioMed Central)
Source: BioMed Central - October 22, 2009 Category: Journals (General) Authors: Peter Nkwo Source Type: journals

Mucosal (oral and vulval) lichen planus in women: are angiotensin-converting enzyme inhibitors protective, and beta-blockers and non-steroidal anti-inflammatory drugs associated with the condition?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Beta-blockers and NSAIDS are associated with LP, suggesting that withdrawal of these drugs should be considered. Further studies are needed to confirm or refute the inverse relationship between mucosal LP and use of ACE inhibitors. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: R. Clayton, S. Chaudhry, I. Ali, S. Cooper, T. Hodgson, F. Wojnarowska Source Type: journals

Topical Beta-Blockers Seen as First-Line Treatment for Glaucoma in PregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Topical beta-blockers can be the first-line drugs for intraocular pressure control for the medical treatment of glaucoma in pregnant women, according to researchers from Taiwan. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines)
Source: Medscape Ob/Gyn & Women's Health Headlines - October 22, 2009 Category: OBGYN Tags: Ophthalmology Source Type: info

Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of EplerenoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates progressive increases in markers of collagen turnover and inflammation in HFPSF with diastolic dysfunction. Despite high background utilization of renin-angiotensin-aldosterone modulators, eplerenone therapy prevents a progressive increase in pro-collagen type-III aminoterminal peptide and may have a role in management of this disease. (The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure; NCT00505336) (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - October 22, 2009 Category: Cardiology Authors: George J. Mak, Mark T. Ledwidge, Chris J. Watson, Dermot M. Phelan, Ian R. Dawkins, Niamh F. Murphy, Anil K. Patle, John A. Baugh, Kenneth M. McDonald Tags: Clinical Research Source Type: journals

Ronald Reagan UCLA Medical Center receives award for excellence in heart careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ronald Reagan UCLA Medical Center has been honored by the American College of Cardiology and the American Heart Association for its commitment to and success in implementing a higher standard of care for heart attack patients. The medical center was one of only 121 hospitals nationwide to be recognized for achieving the aggressive goal of treating acute myocardial infarction patients with high compliance to levels of care outlined by these two leading national organizations dedicated to promoting quality cardiovascular care and reducing mortality from heart disease. The...
Source: UCLA Newsroom: Health Sciences - October 21, 2009 Category: Universities & Medical Training Source Type: organizations

[News in emergency medicine 2009.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is my personal selection of recently published scientific work on pulmonary embolism, classification of circulatory shock, betablockers in acute decompensated heartfailure, advanced cardiac life support, subarachnoid hemorrhage, inhalation therapy with ipratropiumbromide, community acquired pneumonia, diverticulosis, gout and pancreatitis. Last but not least there is a choice of prophylactic interventions, you might not yet be aware of. Some of the discussed publications may help you manage the next patient you'll encounter, when you're on call next time. PMID: 19844880 [PubMed - in process] (Source: Praxis)
Source: Praxis - October 20, 2009 Category: Journals (General) Authors: Heer K Tags: Praxis (Bern 1994) Source Type: journals