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Repetitive Elements and Epigenetic Marks in Behavior and Psychiatric Disease.
Abstract Repetitive elements, which are relics of previous transposition events, constitute a large proportion of the human genome. The ability of transposons to gives rise to new DNA combinations has clearly provided an evolutionary advantage to their hosts. Transposons have shaped our genomes by giving rise to novel coding sequences, alternative gene promoters, conserved noncoding elements, and gene networks. Despite its benefits, the process of transposition can also create deleterious DNA combinations, and a growing number of human diseases are being linked to abnormal repetitive element activity. To limit tran...
Source: Advances in Genetics - August 31, 2014 Category: Genetics & Stem Cells Authors: Darby MM, Sabunciyan S Tags: Adv Genet Source Type: research

An fMRI study of emotional face encoding in youth at risk for bipolar disorder.
Authors: Tseng WL, Bones BL, Kayser RR, Olsavsky AK, Fromm SJ, Pine DS, Leibenluft E, Brotman MA Abstract Face memory deficits may be a bipolar disorder (BD) endophenotype. BD (n=27) and unaffected youth at risk (n=13) exhibited middle frontal gyrus hypoactivation during successful vs. unsuccessful encoding. Parahippocampal gyrus dysfunction was found in BD and at-risk youth (vs. low-risk, n=37). Middle occipital gyrus hypoactivation was only present in BD. PMID: 25172156 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - August 31, 2014 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

ESC: Quadripolar Tops Bipolar in Cardiac Pacing (CME/CE)
BARCELONA (MedPage Today) -- Quadripolar left ventricle lead technology dramatically reduced perioperative complications in implanting cardiac pacemakers for cardiac resynchronization therapy, researchers reported here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 31, 2014 Category: Cardiology Source Type: news

Is There a "Cure" for Bipolar Disorder?
Every now and then I get an email from someone asking this question. Now that it's apparent that bipolar disorder is a physical illness that affects mind and (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 31, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Where Does My Mental Illness End, And Where Do...
Andy BehrmanFrom my friend Andy Electroboy Behrman comes a thoughtful and thought-provoking essay on the journey through life with bipolar disorder. Is (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 31, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Hospital stay in patients admitted for acute bipolar manic episodes prescribed quetiapine immediate or extended release: a retrospective non-interventional cohort study (HOME)
Background: Bipolar manic episodes often require hospital admission to ensure patient safety. The antipsychotic quetiapine is a common treatment for bipolar mania and is available in immediate release (IR) and extended release (XR) formulations; however, outcomes in patients receiving these different formulations have not been directly compared in an acute hospital setting. Methods: We conducted a multinational, observational, retrospective cohort study to describe and compare hospital stay in patients admitted for an acute bipolar manic episode treated with quetiapine IR or XR from 1 October 2009?1 October 2010. The prima...
Source: BMC Psychiatry - Latest articles - August 31, 2014 Category: Psychiatry Authors: O¿uz Karamustafal¿o¿luAndreas ReifMurad AtmacaDomingo GonzalezMiriam Moreno-ManzanaroMiguel GonzalezEsteban MedinaAntonello Bellomo Source Type: research

Bipolar Disorder Genes Uncovered
Novel genes have been identified as possible contributors to bipolar disorder. The condition, also known as manic-depressive illness, is a chronic and devastating psychiatric illness, affecting 0.5-1.6% of the general population across their lifetime. Its causes are not yet fully understood, but genetic factors are thought to play a large role. Professor Markus Nothen of the University of Bonn, Germany, explains, “There is no one gene that has a significant effect on the development of bipolar disorder. Many different genes are evidently involved and these genes work together with environmental factors in a complex w...
Source: Psych Central - August 30, 2014 Category: Psychiatry Authors: Jane Collingwood Tags: Bipolar Disorders Family Genetics Chromosomes Inflammation mania Metabolism Mood Disorder Neuroscience Research Twin Studies Source Type: news

Why Are There So Many Classifications of...
A brief look at the various subsets, descriptions and classifications for bipolar disorder and mood disorders - as defined in the United States and internationally. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 29, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Here's What You Need to Know About Bipolar...
Why do you get bipolar disorder? What are bipolar I and bipolar II, and what are mania, hypomania and bipolar depression? Answers can be found here. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 29, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

4 People - 4 Types of Depression
The first category of symptoms of depressions is low mood. People describe it variously as depression, sadness, emptiness or some similar term. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 29, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Imaging and epicardial substrate ablation of ventricular tachycardia in patients late after myocarditis
Conclusion Pre-procedural scar imaging and EAM findings support the necessity of an epicardial approach in patients with prior myocarditis. Epicardial unipolar mapping (<8 mV) is superior in scar identification and CA based on substrate modification is safe and effective in this setting. (Source: Europace)
Source: Europace - August 29, 2014 Category: Cardiology Authors: Maccabelli, G., Tsiachris, D., Silberbauer, J., Esposito, A., Bisceglia, C., Baratto, F., Colantoni, C., Trevisi, N., Palmisano, A., Vergara, P., De Cobelli, F., Del Maschio, A., Della Bella, P. Tags: Electrophysiology and ablation Source Type: research

In vivo left-ventricular contact force analysis: comparison of antegrade transseptal with retrograde transaortic mapping strategies and correlation of impedance and electrical amplitude with contact force
Conclusions Antegrade vs. retrograde LV-mapping approaches result in different CF. A combined approach to the LV mapping may improve the overall LV mapping, potentially resulting in better clinical outcomes for the left VT catheter ablation. The previous surrogate markers used to assess CF do correlate with in vivo CF; however, due to a larger overlap, their clinical value is limited. (Source: Europace)
Source: Europace - August 29, 2014 Category: Cardiology Authors: Tilz, R. R., Makimoto, H., Lin, T., Rillig, A., Metzner, A., Mathew, S., Deiss, S., Wissner, E., Rausch, P., Kamioka, M., Heeger, C., Kuck, K.-H., Ouyang, F. Tags: TECHNICAL ISSUES Source Type: research

Physico-chemical milling for controlled size reduction of metal beads
Phys. Chem. Chem. Phys., 2014, Accepted ManuscriptDOI: 10.1039/C4CP03279A, CommunicationJerome Roche, Eugenio Gianessi, Alexander KuhnHere we report a new physico-chemical method based on bipolar electrochemistry for producing spherical metal beads with a well-controlled size. Applying an electric field to a low conductivity electrolyte containing...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - August 28, 2014 Category: Chemistry Authors: Jerome Roche Source Type: research

DSM-5 reviewed from different angles: goal attainment, rationality, use of evidence, consequences-part 2: bipolar disorders, schizophrenia spectrum disorders, anxiety disorders, obsessive-compulsive disorders, trauma- and stressor-related disorders, personality disorders, substance-related and addictive disorders, neurocognitive disorders.
Authors: Möller HJ, Bandelow B, Bauer M, Hampel H, Herpertz SC, Soyka M, Barnikol UB, Lista S, Severus E, Maier W Abstract Part 1 of this paper discussed several more general aspects of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and offered a detailed, paradigmatic analysis of changes made to the chapter on depressive disorders. This second part focusses on several other disorders, including bipolar and schizophrenia spectrum disorders. The respective changes and their possible consequences are discussed under consideration of traditional psychiatric classification, particularly from the perspec...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 28, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Corpus callosal morphology in youth with bipolar depression
ConclusionsOur results suggest that commissural fibers of the corpus callosum are disrupted in early‐onset BD. Specific decreases in the anterior and posterior mid‐body callosal aspects may contribute to motor organization and inhibition deficits seen in BD. These findings are consistent with the involvement of inter‐hemispheric tracts in early‐onset BD, which may reflect an early deviation in white matter development. (Source: Bipolar Disorders)
Source: Bipolar Disorders - August 28, 2014 Category: Psychiatry Authors: Frank P MacMaster, Lisa Marie Langevin, Natalia Jaworska, Anne Kemp, Mariko Sembo Tags: Brief Report Source Type: research

Corrigendum
(Source: Bipolar Disorders)
Source: Bipolar Disorders - August 28, 2014 Category: Psychiatry Tags: Corrigendum Source Type: research

4 People - 4 Types of Depression
A discussion of the signs of depression from a less clinical viewpoint, using imaginary people to describe the symptoms of major depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 28, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar Tribocharging Signal During Friction Force Fluctuations at Metal-Insulator Interfaces.
Abstract Friction and triboelectrification of materials show a strong correlation during sliding contacts. Friction force fluctuations are always accompanied by two tribocharging events at metal-insulator [e.g., polytetrafluoroethylene (PTFE)] interfaces: injection of charged species from the metal into PTFE followed by the flow of charges from PTFE to the metal surface. Adhesion maps that were obtained by atomic force microscopy (AFM) show that the region of contact increases the pull-off force from 10 to 150 nN, reflecting on a resilient electrostatic adhesion between PTFE and the metallic surface. The reported r...
Source: Angewandte Chemie - August 28, 2014 Category: Chemistry Authors: Burgo TA, Erdemir A Tags: Angew Chem Int Ed Engl Source Type: research

Episodic memory impairments in bipolar disorder are associated with functional and structural brain changes
ConclusionsChanges in task‐related activation in frontal and parietal areas were associated with poorer episodic memory in patients with BD. Compared with data from single imaging modalities, integration of multimodal neuroimaging data enables the building of more complete neuropsychological models of mental disorders. (Source: Bipolar Disorders)
Source: Bipolar Disorders - August 27, 2014 Category: Psychiatry Authors: Viola Oertel‐Knöchel, Britta Reinke, Richard Feddern, Annika Knake, Christian Knöchel, David Prvulovic, Johannes Pantel, David EJ Linden Tags: Original Article Source Type: research

4 People - 4Types of Depression
A discussion of the signs of depression from a less clinical viewpoint, using imaginary people to describe the symptoms of major depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 27, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Methods For Treating Bipolar Disorder
A treatment plan for bipolar disorder primarily consists of pharmacological intervention (medications) with therapy as a possible intervention. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 27, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar disorder and comorbidity: Increased prevalence and increased relevance of comorbidity for Hospital-based mortality during a 12.5-year observation period in general Hospital admissions
Bipolar disorder (BD) is associated with an increase of psychiatric and physical comorbidities, but the effects of these disorders on general hospital-based mortality are unclear. Consequently, we investigated whether the burden of comorbidity and its relevance on hospital-based mortality differed between individuals with and without BD during a 12.5-year observation period in general hospital admissions. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 26, 2014 Category: Neurology Authors: Dieter Schoepf, Reinhard Heun Source Type: research

Prediction of higher visual function in macular degeneration with multifocal electroretinogram and multifocal visual evoked potential
ConclusionsContextual cueing is more dependent on parafoveal mfERG magnitude while visual acuity is more dependent on parafoveal mfVEP magnitude. The relation of contextual cueing to parafoveal mfERG magnitudes indicates the predictive value of retinal bipolar cell activity for this advanced level of visual function. (Source: Ophthalmic and Physiological Optics)
Source: Ophthalmic and Physiological Optics - August 26, 2014 Category: Opthalmology Authors: Anne Herbik, Franziska Geringswald, Hagen Thieme, Stefan Pollmann, Michael B. Hoffmann Tags: Original Article Source Type: research

'Emerging Biology of PDE10A'
Abstract Cyclic AMP and cyclic GMP are essential second messengers that regulate multiple signaling pathways in virtually all cell types. Their accumulation in cells is finely regulated by cyclic nucleotide phosphodiesterases (PDEs), the only enzymes that can degrade these signaling molecules and thus provide exquisite control over intracellular signaling processes. One PDE family, PDE10A, is highly enriched in the brain and its unique expression profile in specific brain regions of interest, in particular to antipsychotic treatment, has made it an attractive therapeutic target for the treatment of schizophrenia. H...
Source: Current Pharmaceutical Design - August 26, 2014 Category: Drugs & Pharmacology Authors: S Wilson L, Brandon NJ Tags: Curr Pharm Des Source Type: research

D1 Dopamine receptors modulate cone ON bipolar cell Nav channels to control daily rhythms in photopic vision.
Abstract In amphibians, voltage-gated sodium (Nav) channels in cone ON bipolar cells (ON-CBC) amplify cone signals in the dark and in mesopic background light. However, during light adaptation, dopamine, acting through D1 receptors (D1R), suppresses Nav channels and therefore act as a gain control mechanism. Curiously in rodents, Nav channel contributions to the ON-CBC-generated light-adapted electroretinogram (ERG) b-wave appear to exist even in fully light-adapted conditions. We sought to determine how rodent ON-CBC Nav channels are regulated by dopamine via D1R during light adaptation and during the circadian cy...
Source: Chronobiology International - August 26, 2014 Category: Biology Authors: Smith BJ, Côté PD, Tremblay F Tags: Chronobiol Int Source Type: research

What Are Animals Thinking? (Hint: More That You Suspect)
Let’s be honest, you’d probably rather die than wake up tomorrow morning and find out you’d turned into an animal. Dying, after all, is inevitable, and there’s even a certain dignity to it: Shakespeare did it, Einstein did it, Galileo and Washington and Twain all did it. And you, someone who was born a human and will live your life as a human, will end your life that way too. MoreHey, Did I See You Petting Another Dog?Emmys: Jimmy Kimmel Honors Robin Williams With Style NBC NewsJourney Home: How Did the U.S. Free Hostage From Syria Militants? NBC NewsHandcuffed Black Youth Killed Himself, Says Coron...
Source: TIME.com: Top Science and Health Stories - August 25, 2014 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized animal behavior animals Brain communication intelligence social groups tool use Source Type: news

What Are Animals Thinking? (Hint: More Than You Suspect)
Let’s be honest, you’d probably rather die than wake up tomorrow morning and find out you’d turned into an animal. Dying, after all, is inevitable, and there’s even a certain dignity to it: Shakespeare did it, Einstein did it, Galileo and Washington and Twain all did it. And you, someone who was born a human and will live your life as a human, will end your life that way too. MoreHey, Did I See You Petting Another Dog?Nowhere to Hide: U.S. Weighing Airstrikes Against ISIS in Syria NBC NewsEbola Anxiety: Americans Fear 'Large Outbreak' Coming to U.S. NBC News'Breaking Bad' and 'Modern Family' Win Top...
Source: TIME.com: Top Science and Health Stories - August 25, 2014 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized animal behavior animals Brain communication intelligence social groups tool use Source Type: news

Psychopharmacology.
This article reviews mechanisms of action, indications, dosing, side effects, medication interactions, and general management considerations for common medications used to treat psychiatric conditions encountered in the primary care setting. PMID: 25134867 [PubMed - as supplied by publisher] (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - August 25, 2014 Category: Journals (General) Authors: Thronson LR, Pagalilauan GL Tags: Med Clin North Am Source Type: research

Diagnosis and Management of Bipolar Disorder in Primary Care: A DSM-5 Update.
Abstract This review discusses the diagnosis and detection of bipolar disorder in the primary care population with recent changes introduced by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and the pharmacotherapy and psychosocial management of this psychiatric condition. PMID: 25134871 [PubMed - as supplied by publisher] (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - August 25, 2014 Category: Journals (General) Authors: Brenner CJ, Shyn SI Tags: Med Clin North Am Source Type: research

Are confusional arousals pathological?
Conclusions: CAs are highly prevalent in the general population. They are often reported allegedly as a consequence of the treatment of sleep disorders. For the majority of subjects experiencing CAs, no medications were used, but among those who were using medications, antidepressants were most common. Sleep and/or mental disorders were important factors for CAs independent of the use of any medication. (Source: Neurology)
Source: Neurology - August 25, 2014 Category: Neurology Authors: Ohayon, M. M., Mahowald, M. W., Leger, D. Tags: All Psychiatric disorders, Parasomnias, Prevalence studies ARTICLE Source Type: research

10 Things You Need to Know About Zoloft...
Ten important things about the antidepressant sertraline - brand name Zoloft - including information on side effects, withdrawal problems, overdose symptoms, drug interactions and more. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Impaired recognition of happy facial expressions in bipolar disorder.
CONCLUSIONS: Findings suggest a deficit in happy emotion recognition impacted by processing speed. Given the limited sample size, further investigation with a larger patient sample is warranted. PMID: 25142295 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 22, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Suppression of antipsychotic-induced tardive dyskinesia with aripiprazole in an elderly patient with bipolar I disorder.
CONCLUSION: Aripiprazole could be an effective drug in elderly bipolar patients with antipsychotic-induced TD while the patients are in a euthymic state. However, aripiprazole may only suppress TD rather than cure it. PMID: 25142102 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 22, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice.
CONCLUSIONS: These results demonstrate a behaviourally effective oral and chronic regimen for carbamazepine with mood stabilising-like activity in a standard model for mania-like behaviour and two standard models for depression-like behaviour. PMID: 25142097 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 22, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Clinical and neuropsychological characteristics of euthymic bipolar patients having a history of severe suicide attempt - Olié E, Seyller M, Beziat S, Loftus J, Bellivier F, Bougerol T, Azorin JM, Gard S, Kahn JP, Passerieux C, Leboyer M, Etain B, Henry C, Courtet P.
OBJECTIVE: Identifying bipolar patients at high-suicide risk is a major health issue. To improve their identification, we compared dimensional and neuropsychological profile of bipolar patients with or without history of suicide attempt, taking into accoun... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 22, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Pituitary gland volumes in bipolar disorder
Bipolar disorder has been associated with increased Hypothalamic-Pituitary-Adrenal axis function. The mechanism is not well understood, but there may be associated increases in pituitary gland volume (PGV) and these small increases may be functionally significant. However, research investigating PGV in bipolar disorder reports mixed results. The aim of the current study was twofold. First, to assess PGV in two novel samples of patients with bipolar disorder and matched healthy controls. Second, to perform a meta-analysis comparing PGV across a larger sample of patients and matched controls. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 22, 2014 Category: Neurology Authors: Ian A. Clark, Clare E. Mackay, Guy M. Goodwin Source Type: research

Bipolar Electrograms Characteristics at the Left Atrial–pulmonary Vein Junction: towards a New Algorithm for Automated Verification of Pulmonary Vein Isolation
Verification of PV isolation (PVI) is challenging due to co-existence of PV and far-field potentials in bipolar electrograms recorded at the left atrial-pulmonary vein (LA-PV) junction. (Source: Heart Rhythm)
Source: Heart Rhythm - August 22, 2014 Category: Cardiology Authors: Milad El Haddad, Richard Houben, Benjamin Berte, Frederic Van Heuverswyn, Roland Stroobandt, Yves Vandekerckhove, Rene Tavernier, Mattias Duytschaever Source Type: research

Clinical and psychological repercussions of videolaparoscopic tubal ligation: observational, single cohort, retrospective study.
CONCLUSION: Regardless of the technique used, videolaparoscopic tubal ligation had repercussions consisting of increased menstrual flow and premenstrual symptoms, especially in women aged ≤ 35 years, and also had a negative influence on sexual activity. PMID: 25166462 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - August 22, 2014 Category: Journals (General) Authors: Dias DS, Dias R, Nahás-Neto J, Nahás EA, Leite NJ, Bueloni-Dias FN, Modotti WP Tags: Sao Paulo Med J Source Type: research

Imaging Genetics Approaches to Identify Mechanisms in Severe Mental Illness
Schizophrenia, bipolar disorder, and major depressive disorders are heritable serious mental illnesses (SMI). What does this heritability mean? What are the underlying mechanisms? Large genome-wide association studies (GWAS) have identified both shared and unique genetic risk variants for these disorders; however, causal risk variants, their molecular mechanisms, and their effects on brain circuitry are mostly unknown. Targeted, possibly individualized, therapies addressing underlying mechanisms offer the promise of improved functioning and well-being for patients. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 21, 2014 Category: Psychiatry Authors: Steven G. Potkin, Fabio Macciardi, Theo G.M. van Erp Tags: Commentaries Source Type: research

Interface Recombination Current in Type II Heterostructure Bipolar Diodes
ACS Applied Materials & InterfacesDOI: 10.1021/am504454g (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - August 21, 2014 Category: Materials Science Authors: Marius Grundmann, Robert Karsthof and Holger von Wenckstern Source Type: research

The impact of past direct-personal traumatic events on 12-month outcome in first episode psychotic mania: Trauma and early psychotic mania - Daglas R, Conus P, Cotton SM, Macneil CA, Hasty MK, Kader L, Berk M, Hallam KT.
OBJECTIVE: Past traumatic events have been associated with poorer clinical outcomes in people with bipolar disorder. However, the impact of these events in the early stages of the illness remains unclear. The aim of this study was to investigate whether pr... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 21, 2014 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Psychiatric disorders, high-risk behaviors, and chronicity of episodes among predominantly african american homeless chicago youth.
Conclusions. Significant differences were evident between the three time parameters, suggesting that stratification of data by different time variables may benefit homelessness research by identifying meaningful subgroups who may benefit from individualized interventions. PMID: 25130234 [PubMed - in process] (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - August 21, 2014 Category: Global & Universal Authors: Castro AL, Gustafson EL, Ford AE, Edidin JP, Smith DL, Hunter SJ, Karnik NS Tags: J Health Care Poor Underserved Source Type: research

Robin Williams: “I’m Not Manic...
Robin Williams himself denied having either bipolar disorder or clinical depression. In the wake of his suicide, we now know his depression was severe. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What People With Bipolar Are Saying About Robin...
The suicide of Robin Williams hit many with mental illnesses especially hard. Here are some of the things people with bipolar disorder had to say. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Robert Downey, Jr. - Poster Child for...
Actor Robert Downey, Jr. has punctuated a career filled with talent and promise with arrests, imprisonments and time spent in drug rehabilitation. Though he has reportedly been diagnosed with bipolar disorder, nothing has ever been said about his receiving proper treatment for that condition. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Signs of Depression
When taken with other symptoms, increased or decreased appetite and/or quickly gaining or losing weight can be a sign of depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Unipolar Peak‐Negative Voltage as an Endocardial Electrographic Characteristic to Predict Overlying Abnormal Epicardial Substrates in Patients with Right Epicardial Ventricular Tachycardia
ConclusionsIn patients with RV epicardial VT, the presence of unipolar peak‐negative voltage of <1.66 mV in the endocardium predicted the presence of epicardial dense scar (<0.5 mV) and potential ablation targets in the overlying epicardium. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - August 21, 2014 Category: Cardiology Authors: PO‐CHING CHI, YENN‐JIANG LIN, SHIH‐LIN CHANG, LI‐WEI LO, YU‐FENG HU, TZE‐FAN CHAO, FA‐PO CHUNG, JONAN LIAO, TA‐CHUAN TUAN, JEN‐YUAN KUO, JIN‐LONG HUANG, SHIH‐ANN CHEN Tags: Original Article Source Type: research

Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
Abstract To maintain reliable signal transmission across a synapse, free synaptic neurotransmitters must be removed from the cleft in a timely manner. In the first visual synapse, this critical task is mainly undertaken by glutamate transporters (EAATs). Here we study the differential roles of the EAAT1, EAAT2 and EAAT5 subtypes in glutamate (GLU) uptake at the photoreceptor-to-depolarizing bipolar cell synapse in intact dark-adapted retina. Various doses of EAAT blockers and/or GLU were injected into the eye before the electroretinogram (ERG) was measured. Their effectiveness and potency in inhibiting the ERG b-wa...
Source: Vision Research - August 21, 2014 Category: Opthalmology Authors: Tse DY, Chung I, Wu SM Tags: Vision Res Source Type: research

When a Family Member Commits Suicide
There are many ways for one person to leave another's life. Suicide may be the most painful way for those left behind.read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - August 20, 2014 Category: Psychiatry & Psychology Authors: Rachel Pruchno, Ph.D. Tags: Depression Media Psychiatry bipolar disorder family manic depression mental health mental illness relationship robin williams suicide Source Type: news

The effect of personalized guideline-concordant treatment on quality of life and functional impairment in bipolar disorder
The aims of this study were to evaluate correlates and predictors of life functioning and quality of life in bipolar disorder during a comparative effectiveness trial of moderate doses of lithium. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 20, 2014 Category: Neurology Authors: Louisa G. Sylvia, Dustin J. Rabideau, Andrew A. Nierenberg, Charles L. Bowden, Edward S. Friedman, Dan V. Iosifescu, Michael E. Thase, Terence Ketter, Elizabeth A. Greiter, Joseph R. Calabrese, Andrew C. Leon, Michael J. Ostacher, Noreen Reilly-Harrington Source Type: research