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Severe Manic Episode Associated With Tramadol in a Patient With Recurrent Depressive Disorder
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 3, 2015 Category: Psychiatry Tags: Letters to the Editors - Case Reports Source Type: research

An Association Between the Use of Hypnotics and Quit Status in the Treatment of Nicotine Dependence With Varenicline in Bipolar Disorder
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 3, 2015 Category: Psychiatry Tags: Letters to the Editors - Research Reports Source Type: research

A Naturalistic Retrospective Review of Weight Gain in Bipolar Patients Treated With Second Generation Antipsychotics
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - March 3, 2015 Category: Psychiatry Tags: Letters to the Editors - Research Reports Source Type: research

Inositol-Deficient Food Augments a Behavioral Effect of Long-Term Lithium Treatment Mediated by Inositol Monophosphatase Inhibition: An Animal Model With Relevance for Bipolar Disorder
Abstract: Lithium treatment in rodents markedly enhances cholinergic agonists such as pilocarpine. This effect can be reversed in a stereospecific manner by administration of inositol, suggesting that the effect of lithium is caused by inositol monophosphatase inhibition and consequent inositol depletion. If so, inositol-deficient food would be expected to enhance lithium effects. Inositol-deficient food was prepared from inositol-free ingredients. Mice with a homozygote knockout of the inositol monophosphatase 1 gene unable to synthesize inositol endogenously and mimicking lithium-treated animals were fed this diet or a c...
Source: Journal of Clinical Psychopharmacology - March 3, 2015 Category: Psychiatry Tags: Original Contributions Source Type: research

Study offers clues to early detection of bipolar disorders in high-risk children
(Nationwide Children's Hospital) New research published today in the American Journal of Psychiatry indicates a strong link between subthreshold manic episodes and likelihood of developing bipolar disorder in children of parents with bipolar disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 3, 2015 Category: Global & Universal Source Type: news

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities
S McCarroll, P Sklar, R H Perlis & S J Haggarty (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 3, 2015 Category: Psychiatry Authors: J M MadisonF ZhouA NigamA HussainD D BarkerR NehmeK van der VenJ HsuP WolfM FleishmanC O'DushlaineS RoseK ChambertF H LauT AhfeldtE H RueckertS D SheridanD M FassJ NemeshT E MullenL DaheronS McCarrollP SklarR H PerlisS J Haggarty Source Type: research

Mental Illness - What Does It Mean, And What...
Mental illness is a condition that affects a person's mood, behavior or thoughts in a way that is distressing or impairs functioning. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 3, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Flight of Ideas - Symptom of Bipolar and...
class="no-js" itemscope itemtype="http://schema.org/Article" > itemprop="description" >Definition: Flight (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 3, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

DUI Laws DO Apply to Prescriptions!
If your medications affect your driving, consider whether you should BE driving. DUI laws will apply if you are stopped for impaired driving. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 3, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Medicaid Prior Authorization Policies for Pediatric Use of Antipsychotic Medications
Over the past 2 decades, antipsychotic prescribing to youth, almost exclusively comprising atypical antipsychotic medications, was estimated to have increased from 0.16% in 1993-1998 to 1.07% in 2005-2009 in office-based physician visits. Antipsychotic use is also 5-fold greater in Medicaid-insured youth than in privately insured youth, and occurs mostly for youth with clinician-reported externalizing behavior disorders rather than indications approved by the US Food and Drug Administration (FDA) and indications that are evidence-supported without FDA-approved labeling (eg, psychotic disorders, bipolar disorder, autism-rel...
Source: JAMA - March 3, 2015 Category: Journals (General) Source Type: research

With kids' antipsychotic treatment on the rise, study looks at prescriber decision-making
(University of Vermont) More kids nationwide are taking medications designed to treat such mental health illnesses as schizophrenia and bipolar disorder. Vermont pediatricians and psychiatrists conducted a study to determine why. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 2, 2015 Category: Global & Universal Source Type: news

Adverse childhood events and psychosis in bipolar affective disorder [PAPERS]
Conclusions Within affective disorder, the relationship between childhood events and psychosis appears to be relatively symptom-specific. It is possible that the pathways leading to psychotic symptoms differ, with delusions and non-hallucinatory symptoms being influenced less by childhood or early environmental experience. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - March 2, 2015 Category: Psychiatry Authors: Upthegrove, R., Chard, C., Jones, L., Gordon-Smith, K., Forty, L., Jones, I., Craddock, N. Tags: PAPERS Source Type: research

Long-Term Morbidity in Bipolar-I, Bipolar-II, and Unipolar Major Depressive Disorders
Long-term symptomatic status in persons with major depressive and bipolar disorders treated clinically is not well established, although mood disorders are leading causes of disability worldwide. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - March 2, 2015 Category: Neurology Authors: Alberto Forte, Ross J. Baldessarini, Leonardo Tondo, Gustavo H. Vázquez, Maurizio Pompili, Paolo Girardi Tags: Special review article Source Type: research

The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review
Conclusion: This review confirms that psychiatric comorbidity, particularly depression and anxiety, is common in MS. However, the incidence of psychiatric comorbidity remains understudied. Future comparisons across studies would be enhanced by developing a consistent approach to measuring psychiatric comorbidity, and reporting of age-, sex-, and ethnicity-specific estimates. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 2, 2015 Category: Neurology Authors: Marrie, R. A., Reingold, S., Cohen, J., Stuve, O., Trojano, M., Sorensen, P. S., Cutter, G., Reider, N. Tags: Systematic Review Source Type: research

Robotics in the neurosurgical treatment of glioma.
CONCLUSION: Robotic surgical systems can potentially increase safety and performance of surgical operation via novel features such as virtual fixtures, augmented force feedback, and haptic high-force warning system. The case study using neuroArm robot to resect a glioma, for the first time, showed the positional information of surgeon's hand movement and tool-tissue interaction forces. PMID: 25722932 [PubMed] (Source: Hand Surgery)
Source: Hand Surgery - March 1, 2015 Category: Surgery Authors: Sutherland GR, Maddahi Y, Gan LS, Lama S, Zareinia K Tags: Surg Neurol Int Source Type: research

Psychiatric disorders in adolescents and young adults with Down syndrome and other intellectual disabilities
Conclusions: These preliminary observations warrant further studies on genetic, neurological, and psychosocial factors that place some young people with Down syndrome or other IDs at high risk for severe psychiatric illness. (Source: BioMed Central)
Source: BioMed Central - March 1, 2015 Category: Journals (General) Authors: Elisabeth M DykensBhavik ShahBruce DavisCourtney BakerTaylor FifeJeri Fitzpatrick Source Type: research

Affective Disorder - Definition and List
Affective disorders are those mental illnesses which predominantly affect mood and also have an effect on thoughts, behaviors and emotions. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 1, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Lithium Medication
This drug profile outlines the medication Lithium, including common side effects, necessary tests, precautions, warnings, and use during pregnancy. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 1, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Pregnancy and Lamictal
Is Lamictal safe when pregnant? Is the generic lamotrigine safe when breast feeding? Does Lamictal cause birth defects? We try to answer these questions. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 1, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar Disorder Special Diagnosis
This diagnosis is used to document symptoms of bipolar disorder that do not meet the requirements for a diagnosis of bipolar 1 or bipolar 2 disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 1, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

The Complexities Of Manic Depression
Manic depression, known as bipolar disorder, is more than mood swings. It can also feature mixed episodes, cycling, psychotic features and other issues. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 1, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Extrapyramidal Side Effects of Antipsychotic...
Extrapyramidal side effects are a group of symptoms that can occur in persons taking antipsychotic medications. More ... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 1, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

A Dynamic Attenuator Improves Spectral Imaging With Energy-Discriminating, Photon Counting Detectors
Energy-discriminating, photon counting (EDPC) detectors have high potential in spectral imaging applications but exhibit degraded performance when the incident count rate approaches or exceeds the characteristic count rate of the detector. In order to reduce the requirements on the detector, we explore the strategy of modulating the X-ray flux field using a recently proposed dynamic, piecewise-linear attenuator. A previous paper studied this modulation for photon counting detectors but did not explore the impact on spectral applications. In this work, we modeled detection with a bipolar triangular pulse shape (Taguchi , 20...
Source: IEE Transactions on Medical Imaging - March 1, 2015 Category: Biomedical Engineering Source Type: research

A systematic review and meta‐analysis of premature mortality in bipolar affective disorder
ConclusionDespite considerable heterogeneity, all summary SMR estimates and a large majority of individual studies showed elevated mortality in BPAD compared to the general population. This was true for all causes of mortality studied. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - March 1, 2015 Category: Psychiatry Authors: J. F. Hayes, J. Miles, K. Walters, M. King, D. P. J. Osborn Tags: Meta‐analysis Source Type: research

A qualitative investigation into the relationships between social factors and suicidal thoughts and acts experienced by people with a bipolar disorder diagnosis - Owen R, Gooding P, Dempsey R, Jones S.
BACKGROUND: The prevalence rate of completed suicide in bipolar disorder is estimated to be as high as 19%. Social factors or influences, such as stigmatisation and family conflict, contribute to the development of suicidal ideation in clinical and non-cli... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 28, 2015 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder - Breen ME, Seifuddin F, Zandi PP, Potash JB, Willour VL.
OBJECTIVE: Genes and the environment both play a major role in the risk for attempted suicide, and environments harboring stressors, such as early childhood abuse, have been linked to suicidal behavior. Such environments also disrupt the hypothalamic-pitui... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 28, 2015 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

Longitudinal Associations Between Interpersonal Relationship Functioning and Mood Episode Severity in Youth With Bipolar Disorder
This study examined the longitudinal association between mood episode severity and relationships in youth with bipolar (BP) disorder. Participants were 413 Course and Outcome of Bipolar Youth study youth, aged 12.6 ± 3.3 years. Monthly ratings of relationships (parents, siblings, and friends) and mood episode severity were assessed by the Adolescent Longitudinal Interval Follow-up Evaluation Psychosocial Functioning Schedule and Psychiatric Rating Scales, on average, every 8.2 months over 5.1 years. Correlations examined whether participants with increased episode severity also reported poorer relationships and whether fl...
Source: The Journal of Nervous and Mental Disease - February 28, 2015 Category: Psychiatry Tags: Original Articles Source Type: research

Affective processing bias in youth with primary bipolar disorder or primary attention-deficit/hyperactivity disorder
Abstract High rates of comorbidity and overlapping diagnostic criteria between pediatric bipolar disorder (BD) and attention-deficit/hyperactivity disorder (ADHD) contribute to diagnostic and treatment confusion. To advance what is known about both disorders, we compared effect of emotional stimuli on response control in children with primary BD, primary ADHD and typically developing controls (TDC). Participants included 7–17 year olds with either “narrow-phenotype” pediatric BD (n = 25), ADHD (n = 25) or TDC (n = 25). Groups were matched on participant age and FSIQ. The effect of emotional stimuli on...
Source: European Child and Adolescent Psychiatry - February 28, 2015 Category: Psychiatry Source Type: research

Post-partum depressive episodes and bipolar disorder
Publication date: 28 February–6 March 2015 Source:The Lancet, Volume 385, Issue 9970 Author(s): Mustaq Khan , Verinder Sharma (Source: The Lancet)
Source: The Lancet - February 28, 2015 Category: Journals (General) Source Type: research

Increased impulsivity as a vulnerability marker for bipolar disorder: Evidence from self-report and experimental measures in two high-risk populations
Heightened impulsivity has been suggested as a possible risk factor for bipolar disorder (BD). However, studies on high-risk populations are scarce and have mainly focused on individuals with a genetic risk. The present study investigated two high-risk samples for BD with regard to several aspects of the impulsivity construct. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - February 28, 2015 Category: Neurology Authors: Michèle Wessa, Bianca Kollmann, Julia Linke, Sandra Schönfelder, Philipp Kanske Tags: Research report Source Type: research

Risk of Subsequent Dementia Among Patients With Bipolar Disorder or Major Depression: A Nationwide Longitudinal Study in Taiwan
Both major depression and bipolar disorder are associated with an increased risk of developing dementia. However, the differential risk of dementia between major depression and bipolar disorder is rarely investigated. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - February 28, 2015 Category: Health Management Authors: Mu-Hong Chen, Cheng-Ta Li, Chia-Fen Tsai, Wei-Chen Lin, Wen-Han Chang, Tzeng-Ji Chen, Tai-Long Pan, Tung-Ping Su, Ya-Mei Bai Tags: Original Study Source Type: research

Increasing Our Ability to Cope With Stress Can Make Us Healthier, Part 4: Early Life Events That Increase the Response of the Brain to Stress
This is blog four of the series to educate you about stress and to help you increase your ability to cope with stress. Please refer to previous blogs for background information and to review the behaviors that reduce the response of the brain to chronic and acute stress. The focus of this blog is to make you aware of the effects of high levels of stress early in life on the structure and function of the brain, on an individual's susceptibility to mental and physical disease, and also on longevity. Understanding that early life abuse harms both mental and physical health across one's lifespan is the first step to developin...
Source: Healthy Living - The Huffington Post - February 27, 2015 Category: Consumer Health Advice Source Type: news

Macrospirocyclic Oligomer Based on Triphenylamine and Diphenylphosphine Oxide as a Bipolar Host for Efficient Blue Electrophosphorescent Organic Light-Emitting Diodes (OLEDs)
Organic LettersDOI: 10.1021/acs.orglett.5b00292 (Source: Organic Letters)
Source: Organic Letters - February 27, 2015 Category: Chemistry Authors: Kun Chen, Hui-Ru Zhao, Zhao-Kang Fan, Gui Yin, Qing-Min Chen, Yi-Wu Quan, Shu-Hua Li and Shang-Hui Ye Source Type: research

[Correspondence] Post-partum depressive episodes and bipolar disorder
With great interest, we read the Lancet Series on perinatal health. Louise Howard and colleagues' Series paper1 discussed non-psychotic mental disorders in the perinatal period. In the second paper of the Series, Ian Jones and colleagues2 provided a comprehensive overview of post-partum psychotic episodes occurring in the context of bipolar disorder or schizophrenia. Although Howard and colleagues1 methodically reviewed non-psychotic disorders, including major depressive disorder occurring during the perinatal period, an important topic that is not addressed is post-partum depression arising from an underlying bipolar diso...
Source: LANCET - February 27, 2015 Category: Journals (General) Authors: Mustaq Khan, Verinder Sharma Tags: Correspondence Source Type: research

New Internal Clock IdentifiedNew Internal Clock Identified
Researchers have identified a second internal clock in the brain that is desynchronized by changes in dopamine tone, leading to aberrant patterns of arousal similar those in bipolar disorder. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 27, 2015 Category: Consumer Health News Tags: Psychiatry News Source Type: news

The Form Of Bipolar Disorder
Bipolar disorder has three main forms: bipolar 1, bipolar 2 and cyclothymia, which are characterized by either mania or hypomania and depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - February 27, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Coping With Avoidant Behaviors
People well-acquainted with the avoidance behaviors common in depression share their methods of overcoming procrastination. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - February 27, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

The effect of ANK3 bipolar‐risk polymorphisms on the working memory circuitry differs between loci and according to risk‐status for bipolar disorder
This study provides new insights on the neurogenetic correlates of allelic variation at different genome‐wide supported BD‐risk associated ANK3 loci that support their involvement in BD and highlight the modulatory influence of increased background genetic risk for BD. © 2015 Wiley Periodicals, Inc. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - February 26, 2015 Category: Genetics & Stem Cells Authors: Giuseppe Delvecchio, Danai Dima, Sophia Frangou Tags: Research Article Source Type: research

Acute Effects of Concentric vs. Eccentric Exercise on Force Steadiness and Electromyographic Responses of the Forearm Flexors
Abstract: Ye, X, Beck, TW, and Wages, NP. Acute effects of concentric vs. eccentric exercise on force steadiness and electromyographic responses of the forearm flexors. J Strength Cond Res 29(3): 604–611, 2015—The purpose of this study was to examine the acute effects of concentric (CON) vs. eccentric (ECC) exercise on isometric strength, force steadiness, and surface electromyographic (EMG) responses of the forearm flexors. Fifteen resistance-trained men (mean ± SD: age = 23.7 ± 3.5 years; height = 178.9 ± 4.7 cm; body weight = 86.2 ± 9.8 kg) performed 6 sets of 10 maximal CON isokinetic or ECC isokinetic muscle a...
Source: Journal of Strength and Conditioning Research - February 26, 2015 Category: Sports Medicine Tags: Original Research Source Type: research

Second Generation Antipsychotics for Bipolar DisorderSecond Generation Antipsychotics for Bipolar Disorder
There are several second-generation antipsychotics approved for bipolar disorder. What factors influence providers' decisions to prescribe SGAs for these patients? BMC Psychiatry (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 26, 2015 Category: Consumer Health News Tags: Psychiatry Journal Article Source Type: news

Quality of Care for Medicaid-Enrolled Youth with Bipolar Disorders
This study examined conformance to clinical practice guidelines for children and adolescents with bipolar disorders and identified patient and provider factors associated with guideline concordant care. Administrative records were examined for 4,047 Medicaid covered youth aged 5–18 years with new episodes of bipolar disorder during 2006–2010. Main outcome measures included 5 claims-based quality of care measures reflecting national treatment guidelines. Measures addressed appropriate pharmacotherapy, therapeutic drug monitoring, and psychosocial treatment. The results indicated that current treatment practices for you...
Source: Administration and Policy in Mental Health and Mental Health Services Research - February 26, 2015 Category: Psychiatry Source Type: research

Individual and Organizational Predictors of Pediatric Psychiatric Inpatient Admission in Connecticut Hospitals: A 6 Month Secondary Analysis
The objective of this study is to test the hypotheses that bipolar disorders or depressive disorders, minority status, and the presence of pediatric inpatient psychiatric unit will be individual predictors of pediatric psychiatric inpatient admission, and to provide a model that will evaluate which individual and organizational characteristics predict pediatric psychiatric inpatient. For this purpose, a secondary analysis of the medical records of 1,520 pediatric patient visits between January 1, 2008 and June 30, 2008, was conducted using univariate and multivariate logistic regression. Independent predictors of pediatric...
Source: Administration and Policy in Mental Health and Mental Health Services Research - February 26, 2015 Category: Psychiatry Source Type: research

Far field R-wave sensing in Myotonic Dystrophy type 1: right atrial appendage versus Bachmann's bundle region lead placement.
Authors: Russo V, Nigro G, Antonio Papa A, Rago A, Di Meo F, Cristiano A, Molino A, Calabrò R, Giovanna Russo M, Politano L Abstract Aim of the present study was to investigate far field R-wave sensing (FFRS) timing and characteristics in 34 Myotonic Dystrophy type 1 (DM1) patients undergoing dual chamber pacemaker implantation, comparing Bachmann's bundle (BB) stimulation (16 patients) site with the conventional right atrial appendage (RAA) pacing site (18 patients). All measurements were done during sinus rhythm and in supine position, with unipolar (UP) and bipolar (BP) sensing configuration. The presence, ampl...
Source: Acta Myologica - February 26, 2015 Category: Neurology Tags: Acta Myol Source Type: research

DSM-5 reviewed from different angles: goal attainment, rationality, use of evidence, consequences—part 2: bipolar disorders, schizophrenia spectrum disorders, anxiety disorders, obsessive–compulsive disorders, trauma- and stressor-related disorders, personality disorders, substance-related and addictive disorders, neurocognitive disorders
Abstract Part 1 of this paper discussed several more general aspects of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and offered a detailed, paradigmatic analysis of changes made to the chapter on depressive disorders. This second part focusses on several other disorders, including bipolar and schizophrenia spectrum disorders. The respective changes and their possible consequences are discussed under consideration of traditional psychiatric classification, particularly from the perspective of European traditions and on the basis of a PubMed search and review papers. The general conclusion is ...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 26, 2015 Category: Neuroscience Source Type: research

Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia
Abstract The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schi...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 26, 2015 Category: Neuroscience Source Type: research

Modified energy settings are mandatory to minimize oesophageal injury using the novel multipolar irrigated radiofrequency ablation catheter for pulmonary vein isolation
Conclusion An unexpectedly high incidence of thermal EI was noted following PVI using the nMARQ™ with the initial ablation protocol. However, the incidence of thermal EI can be sigificantly reduced with limited power and RF application time at the posterior left atrium. (Source: Europace)
Source: Europace - February 26, 2015 Category: Cardiology Authors: Rillig, A., Lin, T., Burchard, A., Kamioka, M., Heeger, C., Makimoto, H., Metzner, A., Wissner, E., Wohlmuth, P., Ouyang, F., Kuck, K.-H., Tilz, R. R. Tags: Ablation for atrial fibrillation Source Type: research

Discrete potentials guided radiofrequency ablation for idiopathic outflow tract ventricular arrhythmias
Conclusion Discrete potentials and related low-voltage regions were common in idiopathic outflow tract ventricular arrhythmias. Discrete potential- and substrate-guided ablation strategy will help to reduce the recurrence of idiopathic outflow tract arrhythmias. (Source: Europace)
Source: Europace - February 26, 2015 Category: Cardiology Authors: Liu, E., Xu, G., Liu, T., Ye, L., Zhang, Q., Zhao, Y., Li, G. Tags: Cardiac electrophysiology Source Type: research

Fresh Osteochondral Allograft Transplantation for Bipolar Reciprocal Osteochondral Lesions of the Knee
Conclusion: Osteochondral allograft transplantation is a useful salvage treatment option for reciprocal bipolar cartilage lesions of the knee. High reoperation and failure rates were observed, but patients with surviving allografts showed significant clinical improvement. (Source: The American Journal of Sports Medicine)
Source: The American Journal of Sports Medicine - February 26, 2015 Category: Sports Medicine Authors: Meric, G., Gracitelli, G. C., Gortz, S., De Young, A. J., Bugbee, W. D. Tags: Knee, general, Knee, articular cartilage, Allografts Source Type: research

Wnt Signaling Regulates Multipolar-to-Bipolar Transition of Migrating Neurons in the Cerebral Cortex
Publication date: Available online 26 February 2015 Source:Cell Reports Author(s): Michael Boitard , Riccardo Bocchi , Kristof Egervari , Volodymyr Petrenko , Beatrice Viale , Stéphane Gremaud , Eloisa Zgraggen , Patrick Salmon , Jozsef Z. Kiss The precise timing of pyramidal cell migration from the ventricular germinal zone to the cortical plate is essential for establishing cortical layers, and migration errors can lead to neurodevelopmental disorders underlying psychiatric and neurological diseases. Here, we report that Wnt canonical as well as non-canonical signaling is active in pyramidal precursors during radia...
Source: Cell Reports - February 26, 2015 Category: Cytology Source Type: research

Does Ketamine Have Anti-Suicidal Properties? Current Status and Future Directions
Abstract Ketamine, a widely used anesthetic agent, is currently being investigated as a novel therapeutic for depression and suicidality. Ketamine has garnered substantial attention from researchers, clinicians, media outlets, and patients alike, but numerous questions remain. One of the compelling features of ketamine is the rapidity of its antidepressant effects, which peak just 24 h after infusion, setting it apart from other existing treatments. Ketamine’s rapid time course has inspired research efforts to explore its potential as a life-saving therapy for patients at imminent risk of suicide. In this artic...
Source: CNS Drugs - February 26, 2015 Category: Neurology Source Type: research