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The Bipolar Depression Electrical Treatment Trial (BETTER): design, rationale, and objectives of a randomized, sham-controlled trial and data from the pilot study phase - Pereira Junior Bde S, Tortella G, Lafer B, Nunes P, Benseñor IM, Lotufo PA, Machado-Vieira R, Brunoni AR.
Background. Bipolar depression (BD) is a prevalent condition, with poor therapeutic options and a high degree of refractoriness. This justifies the development of novel treatment strategies, such as transcranial direct current stimulation (tDCS) that showe... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 5, 2015 Category: Global & Universal Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news

Clinical characteristics of bipolar disorder: a comparative study between Argentina and the United States - Holtzman JN, Lolich M, Ketter TA, Vazquez GH.
BACKGROUND: Bipolar disorder presents with diverse clinical manifestations. Numerous investigators have sought to identify variables that may predict a more severe illness course. METHODS: With the objective of studying the clinical characteristics... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 5, 2015 Category: Global & Universal Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news

Bipolar hip arthroplasty for avascular necrosis of femoral head in young adults
Conclusion: Bipolar hip arthroplasty (BHA) using tight fitting cup and acetabular reaming in AVN hip has a low incidence of groin pain, acetabular erosion and revision in midterm followup. Good outcome and mid term survival can be achieved irrespective of the Ficat Stage. (Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1))
Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1) - May 5, 2015 Category: Orthopaedics Authors: Baldev DudaniAshok K ShyamPankush AroraArjun Veigus Source Type: research

The physical and degradation properties of starch-graft-acrylonitrile/carboxylated nitrile butadiene rubber latex films
Publication date: 5 September 2015 Source:Carbohydrate Polymers, Volume 128 Author(s): M.A. Misman , A.R. Azura , Z.A.A. Hamid Starch-graft-acrylonitrile (ANS) is compounded with carboxylated nitrile butadiene rubber (XNBR) latex. The control XNBR and the ANS/XNBR latex films were prepared through a coagulant dipping process. The films were subjected to ageing and soil burial procedures. For the biodegradation experiment, the surface of the film was assessed after the 2nd, 4th and 8th week of soil burial. The ANS, XNBR, and ANS/XNBR colloidal stability were determined with a Malvern® Zetasizer. For the dipped latex film...
Source: Carbohydrate Polymers - May 5, 2015 Category: Biomedical Science Source Type: research

BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis
Conclusion This meta-analysis suggests that there is no association between this BDNF polymorphism and hippocampal volumes. For each BDNF genotype, the hippocampal volumes were significantly lower in neuropsychiatric patients than in healthy controls. (Source: Neuroscience and Biobehavioral Reviews)
Source: Neuroscience and Biobehavioral Reviews - May 5, 2015 Category: Neuroscience Source Type: research

Patterns of response to aripiprazole, lithium, haloperidol, and placebo across factor scores of mania
Conclusions: This analysis confirms clinical benefits in early treatment/assessment for subjects with bipolar mania and suggests that certain symptom factors in mixed or manic episodes may be most predictive of treatment response. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - May 5, 2015 Category: Psychiatry Authors: Michael OstacherTrisha SuppesAlan SwannJames EudiconeWally LandsbergRoss BakerBerit Carlson Source Type: research

'Fuzzy thinking' in depression, bipolar disorder: New research finds effect is real
People with depression or bipolar disorder often feel their thinking ability has gotten “fuzzy”, or less sharp than before their symptoms began. Now, researchers have shown in a large study that effect is indeed real – and rooted in brain activity differences that show up on advanced brain scans. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 4, 2015 Category: Science Source Type: news

Mood spectrum disorders in chronic pain patients
Background: Chronic pain is a complex syndrome that affects thinking, mood and behaviour (Nekovarova et al., 2014). It is strongly associated with major depressive disorders (30–40%) but few studies have investigated the prevalence of bipolar disorders in chronic pain patients (Holmes et al., 2012; Nicholl et al., 2014). (Source: Journal of Psychosomatic Research)
Source: Journal of Psychosomatic Research - May 4, 2015 Category: Psychiatry & Psychology Authors: A. Ciaramella, P. Poli Source Type: research

Does severe affective disorder affect renal function?
Background: There is a relationship between affective and somatic morbidity. For instance, patients with bipolar affective disorder (BPAD) and schizophrenia have more diabetes mellitus and a higher cardiovascular mortality. Psychotropic medications seem to only partly account for such associations. The aim of the study was to compare renal function of patients with severe affective disorders with the general population. (Source: Journal of Psychosomatic Research)
Source: Journal of Psychosomatic Research - May 4, 2015 Category: Psychiatry & Psychology Authors: U. Werneke, M. Ott, B. Stegmayr, E. Salander Renberg Source Type: research

Implementing a Web-Based Intervention to Train Community Clinicians in an Evidence-Based Psychotherapy: A Pilot Study.
CONCLUSIONS: Internet-supported e-learning by community clinicians was found to be feasible and led to uptake of an evidence-based psychotherapy comparable to that by clinicians who received face-to-face training. PMID: 25930041 [PubMed - as supplied by publisher] (Source: Psychiatric Services)
Source: Psychiatric Services - May 4, 2015 Category: Psychiatry Tags: Psychiatr Serv Source Type: research

'Fuzzy thinking' in depression & bipolar disorder: New research finds effect is real
(University of Michigan Health System) People with depression or bipolar disorder often feel their thinking ability has gotten 'fuzzy', or less sharp than before their symptoms began. Now, researchers have shown in a very large study that effect is indeed real -- and rooted in brain activity differences that show up on advanced brain scans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 4, 2015 Category: Global & Universal Source Type: news

Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism
ConclusionOur results bring further evidence for the potential involvement of endothelial NOS gene variants in susceptibility to suicidal behaviour. Future exploration of this pathway on larger cohort of suicidal behaviour is warranted. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - May 4, 2015 Category: Psychiatry Authors: J. Oliveira, M. Debnath, B. Etain, M. Bennabi, N. Hamdani, M. Lajnef, D. Bengoufa, C. Fortier, W. Boukouaci, F. Bellivier, J.‐P. Kahn, C. Henry, D. Charron, R. Krishnamoorthy, M. Leboyer, R. Tamouza Tags: Original Article Source Type: research

What You Need to Know About Bipolar Depression
Have you thought the depressed phase of bipolar d/o was just like Major Depression? That could be holding you back. Find out up to date treatment here (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - May 3, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

ZNF804A Genetic Variation Confers Risk to Bipolar Disorder
In this study, we aimed to examine whether ZNF804A may confer susceptibility to BD in Han Chinese. We measured the mRNA expression level of ZNF804A in patients with BD and controls. Two functional variants (rs1344706 and rs359895) in ZNF804A were genotyped among 1508 individuals with or without BD. We then performed a meta-analysis based on present literature. Our results showed that ZNF804A mRNA level in peripheral blood mononuclear cells was significantly higher in BD patients than that in controls (P = 0.01). The rs1344706 showed significant allelic association with BD (P = 0.034). The frequency of T allele of r...
Source: Molecular Neurobiology - May 2, 2015 Category: Neurology Source Type: research

A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report.
This study examined 76 consecutive outpatients with an anxiety disorder plus at least one somatic condition from three domains. More than 80% of the patients had panic attacks, fibromyalgia, and major depressive episodes. Associations were found between joint laxity and bipolar III, headache with bipolar II, and bipolar II with chronic fatigue syndrome. Significant relationships were demonstrated within and between domains, validating ALPIM as a syndrome. PMID: 25923849 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 1, 2015 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

A meta-review of lifestyle interventions for cardiovascular risk factors in the general medical population: lessons for individuals with serious mental illness.
CONCLUSIONS: Studies from the general medical literature demonstrate considerable promise in addressing lifestyle risk factors. Existing programs will require tailoring to address the needs of those with serious mental illness and may be harder to implement given the challenges faced by this population. However, successful lifestyle interventions for those with serious mental illness can make a significant impact on the health and well-being of this vulnerable population and may inform future strategies for other underserved groups. PMID: 25919840 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 1, 2015 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Illness perception of dropout patients followed up at bipolar outpatient clinic, Turkey.
In conclusion, the nonattendance of patients with serious mental illness can result in non-compliance of therapeutic drug regimens, and a recurrence of the appearance symptoms. The perception of illness in dropout patients with BD may be important for understanding and preventing nonattendance. PMID: 25921931 [PubMed - as supplied by publisher] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - May 1, 2015 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Antidepressant Effects of Open Label Treatment With Coenzyme Q10 in Geriatric Bipolar Depression
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - May 1, 2015 Category: Psychiatry Tags: Letters to the Editors - Research Reports Source Type: research

A 13-Week, Randomized Double-Blind, Placebo-Controlled, Cross-Over Trial of Ziprasidone in Bipolar Spectrum Disorder
Objective: Features of bipolarity in a major depressive disorder sample were used to define a “bipolar spectrum disorder” population for treatment with a neuroleptic agent, ziprasidone. Methods: Forty-nine acutely depressed patients were randomized to ziprasidone-washout-placebo or placebo-washout-ziprasidone in this double-blind, prospective, 13-week crossover trial. All patients met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for a major depressive episode and were positive for at least 3 predictors of bipolarity: family history of bipolar disorder, antidepressant-induced mania...
Source: Journal of Clinical Psychopharmacology - May 1, 2015 Category: Psychiatry Tags: Brief Reports Source Type: research

Just A Reminder That There's Nothing Wrong With Going To Therapy
"Therapy" is often regarded as an unsavory word, viewed as an admission that someone's not totally together. But here's the reality: There's absolutely nothing wrong with needing or wanting to get help. Mental health is a landscape that many people still don't understand (in fact, only 25 percent of people with mental illness feel that others are compassionate toward them). The term "bipolar" is casually thrown around when someone can't make a decision on their hairstyle, or folks call themselves "OCD" when they feel the need to organize their desks. Mental illness is viewed as something that's "all in your head" or you...
Source: Healthy Living - The Huffington Post - May 1, 2015 Category: Consumer Health Advice Source Type: news

Association between the dopamine transporter gene (DAT1) and attention deficit hyperactivity disorder-related traits in healthy adults
Conclusion: Our study results suggest that DAT1 polymorphisms may modulate mood instability traits in the normal population. Considering that mood instability tends to persist through the entire course of ADHD and is highly prevalent in many diseases that are comorbid with ADHD, this trait may be a core endophenotype that defines the role of the DAT1 gene in various psychiatric conditions. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder
Conclusion: Our findings suggest that further work and larger sample sizes are required to elucidate the link between early childhood abuse and the HPA axis in suicidal behavior. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - May 1, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

Immune abnormalities across psychiatric disorders: clinical relevance [Articles]
It is well established that the immune system can modulate brain functioning and influence behavioural processes. Awareness of communication between the immune and nervous systems has, over the years, progressively heightened interest in the relationship between psychiatric disorders and immune function. By reviewing findings from studies investigating inflammation in the periphery and in the central nervous systems, we summarise here the evidence linking inflammation to the development of depression, schizophrenia and bipolar disorder. We discuss how a pathophysiological role for inflammation has now been recognised acros...
Source: Advances in Psychiatric Treatment - May 1, 2015 Category: Psychiatry Authors: Mondelli, V., Dazzan, P., Pariante, C. M. Tags: Articles Source Type: research

Collaborative care for patients with bipolar disorder: randomised controlled trial [PAPERS]
Conclusions When compared with treatment as usual, collaborative care substantially reduced the time participants with bipolar disorder experienced depressive symptoms. Also, depressive symptom severity decreased significantly. As persistent depressive symptoms are difficult to treat and contribute to both disability and impaired quality of life in bipolar disorder, collaborative care may be an important form of treatment for people with this disorder. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - May 1, 2015 Category: Psychiatry Authors: van der Voort, T. Y. G., van Meijel, B., Goossens, P. J. J., Hoogendoorn, A. W., Draisma, S., Beekman, A., Kupka, R. W. Tags: PAPERS Source Type: research

Reduced interhemispheric resting‐state functional connectivity in unmedicated bipolar II disorder
ConclusionThese findings suggest substantial impairment of interhemispheric coordination in BD II. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - May 1, 2015 Category: Psychiatry Authors: Y. Wang, S. Zhong, Y. Jia, Z. Zhou, Q. Zhou, L. Huang Tags: Original Article Source Type: research

Lithium modulates the production of peripheral and cerebral cytokines in an animal model of mania induced by dextroamphetamine
ConclusionsLi modulates peripheral and cerebral cytokine production in an animal model of mania induced by d‐AMPH, suggesting that its action on the inflammatory system may contribute to its therapeutic efficacy. (Source: Bipolar Disorders)
Source: Bipolar Disorders - May 1, 2015 Category: Psychiatry Authors: Samira S Valvassori, Paula T Tonin, Roger B Varela, André F Carvalho, Edemilson Mariot, Rafaela T Amboni, Guilherme Bianchini, Monica L Andersen, João Quevedo Tags: Original Article Source Type: research

Effects of ECT in treatment of depression: study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function
DiscussionThe study will contribute to our understanding of the pathophysiology of major depression as well as mechanisms of action for the most effective treatment for the disorder; ECT. (Source: BMC Psychiatry)
Source: BMC Psychiatry - May 1, 2015 Category: Psychiatry Authors: Leif OltedalUte KesslerLars ErslandRenate GrünerOle AndreassenJan HaavikPer HoffÅsa HammarAnders DaleKenneth HugdahlKetil Oedegaard Source Type: research

A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update
Conclusions This meta-analysis shows that HoLEP is associated with more favorable outcomes than M-TURP in published RCTs. B-TURP and PVP have resulted in better perioperative outcomes without significant differences regarding efficacy parameters after short-term follow-up compared with M-TURP. Further studies are needed to provide long-term comparative data and head-to head comparisons of emerging techniques. Patient summary Bipolar transurethral resection of the prostate, photovaporization of the prostate, and holmium laser enucleation of the prostate have shown efficacy outcomes comparable with conventional techniques y...
Source: European Urology - May 1, 2015 Category: Urology & Nephrology Source Type: research

Predictors of functional outcome after A manic episode
The identification of functional outcome predictors after acute episodes of bipolar disorders (BD) may allow designing appropriate treatment aiming at restoring psychosocial functioning. Our objective was to identify the best functional outcome predictors at a 6-month follow-up after an index manic episode. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - May 1, 2015 Category: Neurology Authors: C. Mar Bonnín, María Reinares, Diego Hidalgo-Mazzei, Juan Undurraga, Maria Mur, Cristina Sáez, Evaristo Nieto, Gustavo H. Vázquez, Vicent Balanzá-Martínez, Rafael Tabarés-Seisdedos, Eduard Vieta Tags: Research report Source Type: research

Including family members in psychoeducation for bipolar disorder: is it worth it?
(Source: Bipolar Disorders)
Source: Bipolar Disorders - May 1, 2015 Category: Psychiatry Authors: Mario Luciano, Valeria Del Vecchio, Gaia Sampogna, Corrado De Rosa, Andrea Fiorillo Tags: Letter to the Editor Source Type: research

Outpatient Follow-Up Visits After Hospital Discharge for Mental Illness and Implications for re-admissions
This study evaluated rates of follow-up visits and implications for re-admissions for patients with schizophrenia or bipolar disorder using administrative claims data. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: I. Lin, E. Muser, M. Munsell, J. Menzin Source Type: research

Assessing the full burden of care for agitation in patients with Schizophrenia and Bipolar I disorder
Patient care burden to health professionals (HPs) and health care institutions for many disorders, including agitation in schizophrenia or bipolar I disorder, may not be fully captured through claims data and/or medical records. The study objective was to assess this burden, specifically for agitated patients with schizophrenia and bipolar I disorder who visit emergency departments or psychiatric emergency service units. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: M.K. Margolis, B. Bapat, S. Blume, S. Cicero, S.K. Gandhi Source Type: research

Reimbursment and prescribing in exchange-based plans: how does formulary generosity differ from commercial plans and is indication a key factor?
This study examined formulary decisions made by managed care organizations for their exchange-based plans, and assessed the impact of these decisions on brand prescribing for asthma, bipolar disorder, and multiple sclerosis, to discern differences between indications. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: R. Moore, C. Lewis Source Type: research

Cardiovascular Safety With The Concurrent Use Of Mood Stabilizers Or Atypical Antipsychotics And Stimulants In Children And Adolescents With Attention Deficit/Hyperactivity Disorder And Bipolar Disorder
This study compared the cardiovascular safety of the addition of mood stabilizers or atypical antipsychotics to stimulant monotherapy in children and adolescents diagnosed with ADHD and bipolar disorder. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: P. Rane, Bali, R.R. Aparasu Source Type: research

Qualitative study of Patients’ preferences for Bipolar Depression Treatment
Patient focus groups were conducted to identify the most important clinical attributes and outcomes of pharmacological treatments for bipolar depression influencing patients’ treatment adherence decisions. Qualitative results will guide the development of a quantitative discrete choice experiment to determine patient preferences and willingness to trade-off between medication characteristics. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: D.S. Ng-Mak, J.L. Poon, K. Rajagopalan, L. Kleinman, L. Roberts, D.A. Revicki, A. Loebel Source Type: research

A Cost-effectiveness model to Guide Health policy in Bipolar Disorder Treatment
To evaluate the cost-effectiveness of bipolar disorder (I and II) treatments to assist in efficient resource allocation. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: M.L. Chatterton, C. Mihalopoulos, J. Barendregt, M. Berk, P.B. Mitchell, J. Khoo, R. Carter Source Type: research

Changes in Healthcare costs associated with the Treatment of Bipolar Disorder following initiation of Asenapine versus Aripiprazole
To assess differences in healthcare costs associated with initiation of asenapine versus aripiprazole among patients with bipolar disorder (BD). (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: A. Chitnis, R. Wang, S.X. Sun, S. Dixit, A. Tawah, L. Boulanger Source Type: research

The impact of alternative Antipsycontic Medications on the risk of adverse events in patients treated for Bipolar disorders
This study compares the risks of side effects [SE] associated with a broad of range of atypical and typical antipsychotics used to treatment patients with bipolar disorder. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: Y. Jiang, S. Park, J. McCombs Source Type: research

The Importance of Having an Advocate
One of the most important things I have learned while on this journey of living with bipolar disorder is that it is imperative to have an advocate. For the most part I have my illness under control; however, bipolar disorder is a tricky illness. It can lie dormant for quite some time with the help of medications and therapy, yet the things we call “triggers” can awaken that beast rather quickly. Triggers are real, and specific to individuals. What triggers me, or sets my moods cycling, may have little or no effect on someone else. For example, I know how busy my neighborhood grocery store is on the weekend. It ...
Source: Psych Central - April 30, 2015 Category: Psychiatry Authors: Nicole Lyons Tags: Anti-anxiety Bipolar Caregivers Disorders Family General Medications Panic Disorder Personal Stories Psychology Advocate Bipolar Disorder Caregiving Catastrophize mania Manic Episode Mental Health Advocacy Mood Cycling Source Type: news

A comparative study of caregivers’ perceptions of health-care needs and burden of patients with bipolar affective disorder and schizophrenia
Nordic Journal of Psychiatry, Ahead of Print. (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - April 30, 2015 Category: Psychiatry Tags: article Source Type: research

Validity and reliability of the Finnish version of the Functioning Assessment Short Test (FAST) in bipolar disorder
Background: The Functioning Assessment Short Test (FAST) was developed for the clinical evaluation of functional impairment of patients suffering from bipolar disorder. The aim of this study was to validate the Finnish version of FAST. Methods: Translation and back-translation of FAST were performed. Fifty patients with the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) bipolar type I and II were interviewed at the Bipolar Disorder Research and Treatment Centre, City of Helsinki, Finland. Participants completed the FAST, the Social and Occupational Functioning Assessment Scale (SOFAS) of DSM-...
Source: BioMed Central - April 30, 2015 Category: Journals (General) Authors: Kirsi SuominenElina SalminenSusanna LähteenmäkiTiina TupalaErkki Isometsä Source Type: research

Tuning Charge Balance in Solution-Processable Bipolar Triphenylamine-diazafluorene Host Materials for Phosphorescent Devices
ACS Applied Materials & InterfacesDOI: 10.1021/am509014v (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - April 30, 2015 Category: Materials Science Authors: Zhaokang Fan, Huiru Zhao, Nengquan Li, Yiwu Quan, Qingmin Chen, Shanghui Ye, Shuhua Li, Ying Wang, Quli Fan and Wei Huang Source Type: research

The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors
This study evaluated the effects of asenapine in a validated test battery for manic-like behaviors in Black Swiss mice. Male Black Swiss mice received asenapine at 0.03, 0.1, and 0.3 mg/kg twice daily for 7 days and were tested for spontaneous activity, sweet solution preference, forced-swim test, social interaction, and amphetamine-induced hyperactivity. Asenapine treatment resulted in dose-dependent, clinically relevant plasma levels. Asenapine, at the 0.1 and 0.3 mg/kg doses, reduced activity, with the 0.3 mg/kg dose also resulting in increased time in the center of an open field, increased immobility in the force...
Source: Behavioural Pharmacology - April 30, 2015 Category: Drugs & Pharmacology Tags: Research Reports Source Type: research

Introducing Female Black Swiss Mice: Minimal Effects of Sex in a Strain-Specific Battery of Tests for Mania-Like Behavior and Response to Lithium
This study was therefore designed to examine the possibility of using both male and female BS mice in future studies. Groups of male and female BS mice were compared with each other, with or without lithium treatment, in tests for domains of mania-like behavior including activity in an open field, sweet solution preference, elevated plus maze, forced swim and amphetamine-induced hyperactivity. The results indicate mostly a similarity between female and male BS mice, both naïve and after chronic lithium treatment. The results are discussed in the context of the deficiency in utilizing female mice in animal models research ...
Source: Pharmacology - April 30, 2015 Category: Drugs & Pharmacology Source Type: research

Confusing borderline personality with severe bipolar illness
(Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - April 30, 2015 Category: Psychiatry Authors: S. N. Ghaemi, S. Barroilhet Tags: Commentary Source Type: research

Brain structure in schizophrenia vs. psychotic bipolar I disorder: A VBM study
In this study, we used voxel-based morphometry (VBM8) in 34 schizophrenia patients, 17 euthymic bipolar I disorder patients (with a history of psychotic symptoms), and 34 healthy controls. Our results indicate that compared to healthy controls schizophrenia patients show grey matter deficits (p (Source: Schizophrenia Research)
Source: Schizophrenia Research - April 30, 2015 Category: Psychiatry Authors: Igor Nenadic, Raka Maitra, Kerstin Langbein, Maren Dietzek, Carsten Lorenz, Stefan Smesny, Jürgen R. Reichenbach, Heinrich Sauer, Christian Gaser Source Type: research

Radiofrequency Thermal Ablation versus Bipolar Electrocautery for the Treatment of Inferior Turbinate Hypertrophy: Comparison of Efficacy and Postoperative Morbidity
Conclusion Submucosal cauterization with preservation of the nasal mucosa and periosteum is as effective and safe as RFTA and should be considered when planning inferior turbinate interventions.[...]Thieme Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - April 30, 2015 Category: ENT & OMF Authors: Uluyol, SinanKarakaya, Nermin ErdasGur, Mehmet HafitKilicaslan, SaffetKantarcioglu, Esin OzlemYagiz, OzlemArslan, Ilker Burak Tags: Original Research Source Type: research

FDA grants approval for generic version of antipsychotic drug Abilify
The US Food and Drug Administration (FDA) has granted approval for the first generic versions of Abilify (aripiprazole), which is an atypical antipsychotic drug to treat schizophrenia and bipolar disorder. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - April 29, 2015 Category: Pharmaceuticals Source Type: news

Predictors of the Onset of Schizophrenia in US Military Personnel
We examined the associations of pentraxin-3 (PTX3) with the onset of schizophrenia or bipolar disorder. We tested preonset serum specimens from 160 US military service members who were later diagnosed with schizophrenia or bipolar disorder and 160 matched controls without psychiatric disorders. Lower serum levels of PTX3 were predictive of schizophrenia but not of bipolar disorder. Subjects with below-median PTX3 levels had a 3.0 odds ratio (confidence interval, 1.6–5.7) for schizophrenia onset in the multivariable logistic regression model controlling for demographic and military variables. The test for trends was signi...
Source: The Journal of Nervous and Mental Disease - April 29, 2015 Category: Psychiatry Tags: Original Articles Source Type: research

Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior
In this study we used a genetic system to titrate the rate of GPCR signaling in ON-BC dendrites by varying the concentration of key RGS proteins and measuring the impact on transmission of signal between photoreceptors and ON-BC neurons using electroretinography and single cell recordings. We found that sensitivity, onset timing, and the maximal amplitude of light-evoked responses in rod- and cone-driven ON-BCs are determined by different RGS concentrations. We further show that changes in RGS concentration differentially impact visually guided-behavior mediated by rod and cone ON pathways. These findings illustrate that n...
Source: eLife - April 29, 2015 Category: Biomedical Science Authors: Sarria, I., Pahlberg, J., Cao, Y., Kolesnikov, A. V., Kefalov, V. J., Sampath, A. P., Martemyanov, K. A. Tags: Neuroscience Source Type: research