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Proteomic analysis of rat prefrontal cortex after chronic valproate treatment
Valproic acid (VPA) is commonly used to treat bipolar disorder (BD), but its therapeutic role has not been clearly elucidated. To gain insights into VPA's mechanism of action, proteomic analysis was used to identify differentially expressed proteins in the rat prefrontal cortex (PFC), a region particularly affected in BD, after 6 weeks of VPA treatment. Proteins from PFCs of control and VPA‐treated rats were separated by 2D‐DIGE and identified by mass spectrometry. Among the 2,826 protein spots resolved, the abundance of 19 proteins was found to be significantly altered in the VPA‐treated group (with the levels of th...
Source: Journal of Neuroscience Research - April 2, 2014 Category: Neuroscience Authors: Muthusamy Thangavel, Ratnam S. Seelan, Jaganathan Lakshmanan, Robert E. Vadnal, John I. Stagner, Latha K. Parthasarathy, Manuel F. Casanova, Rifaat Shody El‐Mallakh, Ranga N. Parthasarathy Tags: Research Article Source Type: research

Quetiapine-Related Tic in a Pediatric Bipolar Patient
Journal of Child and Adolescent Psychopharmacology , Vol. 0, No. 0. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - April 1, 2014 Category: Pediatrics Tags: article Source Type: research

A long self life
Egomania is an obsessive preoccupation with one's self and applies to someone who follows their own ungoverned impulses and is possessed by delusions of personal greatness and feels a lack of appreciation. But what does the psychological literature say on the topic?read more (Source: Psychology Today Personality Center)
Source: Psychology Today Personality Center - April 1, 2014 Category: Psychiatry & Psychology Authors: Dr. Mark D. Griffiths, Ph.D. Tags: Addiction Personality celebrity Egocentric behaviour egocentricism Egomania Egomaniac fame Loving oneself Manic behaviour megalomania narcissistic personality disorder obsession politicians Source Type: news

Mp1-04 dramatic effects of bilateral bipolar l6-s1 trunk neurostimulation on continuous cystometric parameters before and after bladder irritation
(Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2014 Category: Urology & Nephrology Authors: Matthew O. Fraser, Alexis A. Dieter, Danielle J. Degoski, Paul C. Dolber Tags: Urodynamics/Incontinence/Female Urology (MP1) Source Type: research

Common and Costly Hospitalizations for Pediatric Mental Health Disorders
The pediatric mental health burden is substantial, with >4 million children meeting criteria for a mental health disorder. Mental health is a key priority for national pediatric inpatient quality measures, but little is known about admitted patients and their diagnoses. Nationally, nearly 10% of hospitalizations in children >3 years are for primary mental health diagnoses. The most common and costly are depression, bipolar disorder, and psychosis. Fewer free-standing children’s hospitalizations (3%) were for mental health admissions, although diagnostic distributions were similar. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - April 1, 2014 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Common and Costly Hospitalizations for Pediatric Mental Health Disorders
CONCLUSIONS: We identified the child mental health inpatient diagnoses with the highest frequency and highest costs as depression, bipolar disorder, and psychosis, with substance abuse an important comorbid diagnosis. These diagnoses can be used as priority conditions for pediatric mental health inpatient quality measurement. (Source: PEDIATRICS)
Source: PEDIATRICS - April 1, 2014 Category: Pediatrics Authors: Bardach, N. S., Coker, T. R., Zima, B. T., Murphy, J. M., Knapp, P., Richardson, L. P., Edwall, G., Mangione-Smith, R. Tags: Article Source Type: research

Is borderline personality disorder a mood disorder? [EDITORIALS]
Borderline personality disorder is by its very naming positioned as an Axis II personality disorder and thus seemingly distinct from an Axis I mood state. Clinical differentiation of those with a borderline condition and those with a bipolar disorder is commonly held to be difficult, so raising the question as to whether they may be independent or interdependent conditions, and allowing several possible answers. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - April 1, 2014 Category: Psychiatry Authors: Parker, G. Tags: EDITORIALS Source Type: research

Working memory networks and activation patterns in schizophrenia and bipolar disorder: comparison with healthy controls [PAPERS]
Conclusions The same brain networks were related to working memory in schizophrenia, bipolar disorder and controls. However, some key networks showed a graded hyperactivation in the two patient groups, in line with a continuum of neuronal abnormalities across psychotic disorders. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - April 1, 2014 Category: Psychiatry Authors: Brandt, C. L., Eichele, T., Melle, I., Sundet, K., Server, A., Agartz, I., Hugdahl, K., Jensen, J., Andreassen, O. A. Tags: PAPERS Source Type: research

Lithium dually regulates GIRK channels [Neuroscience]
Lithium (Li+) is widely used to treat bipolar disorder (BPD). Cellular targets of Li+, such as glycogen synthase kinase 3β (GSK3β) and G proteins, have long been implicated in BPD etiology; however, recent genetic studies link BPD to other proteins, particularly ion channels. Li+ affects neuronal excitability, but the underlying... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 1, 2014 Category: Science Authors: Farhy Tselnicker, I., Tsemakhovich, V., Rishal, I., Kahanovitch, U., Dessauer, C. W., Dascal, N. Tags: Biological Sciences Source Type: research

Reliability of clinical office-based laryngeal electromyography in vocally healthy adults.
CONCLUSION: Using a quantitative analysis protocol to inform an essentially qualitative technique, our results indicated that there was generally poor to fair reliability in the LEMG signal over testing sessions. Vocal intensity was an important variable that affected LEMG signal reliability. Standardization of LEMG protocols using vocal control parameters and quantitative analyses may help improve LEMG reliability in clinical settings. PMID: 24671483 [PubMed - in process] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - April 1, 2014 Category: ENT & OMF Authors: Croake DJ, Stemple JC, Uhl T, Archer S, Andreatta RD Tags: Ann Otol Rhinol Laryngol Source Type: research

Mp71-04 the long term outcome of bipolar plasma enucleation in large bph cases - the test of time in a prospective, randomized comparison to open prostatectomy
(Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2014 Category: Urology & Nephrology Authors: Bogdan Geavlete, Florin Stanescu, Cristian Moldoveanu, Marian Jecu, Leon Adou, Cosmin Ene, Catalin Bulai, Petrisor Geavlete Tags: Benign Prostatic Hyperplasia: Surgical Therapy & New Technology II (MP71) Source Type: research

Pd26-02 vascular endothelial growth factor (vegf) and cd34 to evaluate if dutasteride can reduce intraoperative bleeding during bipolar trans-urethral resection of the prostate
(Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2014 Category: Urology & Nephrology Authors: Gian Maria Busetto, Riccardo Giovannone, Gabriele Antonini, Vincenzo Gentile, Ettore De Berardinis Tags: Benign Prostatic Hyperplasia: Surgical Therapy & New Technology I (PD26) Source Type: research

Mp56-08 incidence of severe bladder injury among the monopolar and bipolar transurethral resection of bladder tumor: a population-based study based on 28141 cases
(Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2014 Category: Urology & Nephrology Authors: Toru Sugihara, Hideo Yasunaga, Hiromasa Horiguchi, Michael Kattan, Kiyohide Fushimi, Yukio Homma Tags: Bladder Cancer: Superficial (MP56-01) Source Type: research

Methylene Blue Used in the Treatment of Refractory Shock Resulting from Drug Poisoning: Fisher J, Taori G, Braitberg G, et al. Clin Toxicol 2013;52:63–5.
Methylene blue is commonly recognized as a treatment for methemoglobinemia, but reports have also shown its utility in the treatment of vasodilatory shock as a result of sepsis, postcardiac bypass, and toxic ingestions, including metformin and amlodipine. The proposed mechanism for this action is the interruption of the nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathway, resulting in decreased smooth muscle relaxation. This case report described the use of methylene blue as a rescue agent in severe refractory hypotension resulting from polypharmacy ingestion. A 41-year-old man with a history of epilepsy and bi...
Source: The Journal of Emergency Medicine - March 31, 2014 Category: Emergency Medicine Authors: W. Gannon Sungar Tags: Abstracts Source Type: research

Novel Stem Cell Research to Shed Light on Bipolar DisorderNovel Stem Cell Research to Shed Light on Bipolar Disorder
Stem cell-derived neurons from patients with bipolar disorder promise to shed light on the origins of the disease and point to new treatments. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - March 31, 2014 Category: Psychiatry Tags: Psychiatry News Source Type: news

Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder
We examined gene expression (mRNA) and protein levels of candidate immune and neurotrophic markers in well-characterized offspring of bipolar parents in order to identify reliable indicators of illness risk status and the early clinical stages of illness development. We measured mRNA expression and protein levels in candidate immune (TNF-alpha, IL-1beta, IL-10, IFN-delta) and neurotrophic (brain-derived neurotrophic factor (BDNF)) markers from plasma. High-risk offspring were identified from families in which one parent had confirmed bipolar disorder. Control offspring were identified from families in which neither parent ...
Source: Epidemiologic Perspectives and Innovations - March 31, 2014 Category: Epidemiology Authors: Anne DuffyJulie HorrocksSarah DoucetteCharles Keown-StonemanPaul GrofAna AndreazzaL Trevor Young Source Type: research

Surgical therapy for benign prostatic hypertrophy/bladder outflow obstruction
Nikesh ThiruchelvamIndian Journal of Urology 2014 30(2):202-207Monopolar transurethral resection of the prostate (TURP) with endoscopic electrocautery remains the gold standard surgical technique for benign prostatic hypertrophy (BPH) by which all new procedures are compared. We reviewed the current literature, and international urological guidelines and consensus opinion on various surgical options for BPH and present a brief overview of alternative techniques including bipolar TURP, transurethral incision of the prostate, transurethral vaporization of the prostate, laser prostatectomy (with holmium, thulium and potassium...
Source: Indian Journal of Urology - March 29, 2014 Category: Urology & Nephrology Authors: Nikesh Thiruchelvam Source Type: research

Development of acute pancreatitis caused by sodium valproate in a patient with bipolar disorder on hemodialysis for chronic renal failure: a case report
Conclusion: It has been reported that acute pancreatitis induced by VPA is caused by intermediate metabolites of VPA. We consider that patients with renal failure are prone to pancreatitis caused by VPA because of the accumulation of these intermediate metabolites. We need close monitoring for serious adverse effects such as pancreatitis when we prescribe VPA to patients with bipolar disorder on hemodialysis for chronic renal failure, although VPA is safer than other mood stabilizers. (Source: BMC Psychiatry - Latest articles)
Source: BMC Psychiatry - Latest articles - March 29, 2014 Category: Psychiatry Authors: Hiroaki OkayasuTakahiro ShinozakiAkira OsoneYuji OzekiKazutaka Shimoda Source Type: research

Science News » Brain Region Singled Out for Social Memory, Possible Therapeutic Target for Select Brain Disorders
The hippocampus houses learning and memory—specifically the storage of knowledge of who, what, where, and when. Using a special transgenic mouse, researchers have now pinpointed a hippocampal region called CA2 that is important for social memory, the ability of animal to recognize another of the same species. Understanding this region could be useful in understanding and treating disorders characterized by altered social behaviors such as schizophrenia, bipolar disorder, and autism. (Source: National Institute of Mental Health)
Source: National Institute of Mental Health - March 28, 2014 Category: Psychiatry Authors: Jackie Oberst Source Type: news

Synthesis of dimesitylborane-substituted phenylcarbazoles as bipolar host material and green PHOLED performances with substitute position of boron atom
Dalton Trans., 2014, Accepted ManuscriptDOI: 10.1039/C4DT00101J, CommunicationHong-Gu Jang, Bo Seong Kim, Jun Yeob Lee, Seok-Ho HwangTwo structural isomers of bipolar host material containing dimesitylborane moiety were synthesized and their device performance were investigated. Quantum efficiency of their device took place depending on the substituent position...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - March 28, 2014 Category: Chemistry Authors: Hong-Gu Jang Source Type: research

Older Men Are More Likely to Have Children With...
Research confirms that older men are more likely than younger men to father children with mental disorders, including bipolar, ADHD and autism. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 28, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Inspiration linked to bipolar disorder risk
Inspiration has been linked with people at risk of developing bipolar disorder for the first time in a study. For generations, artists, musicians, poets and writers have described personal experiences of mania and depression, highlighting the unique association between creativity and bipolar disorder -- experiences which are backed up by recent research. But, until now, the specific links between inspiration -- the generation of ideas that form the basis of creative work -- and bipolar disorder has received little attention. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 27, 2014 Category: Science Source Type: news

An Examination of the Strength and Electromyographic Responses After Concentric Vs. Eccentric Exercise of the Forearm Flexors
Abstract: Ye, X, Beck, TW, DeFreitas, JM, and Wages, NP. An examination of the strength and electromyographic responses after concentric vs. eccentric exercise of the forearm flexors. J Strength Cond Res 28(4): 1072–1080, 2014—The purpose of this study was to examine the strength and electromyographic (EMG) responses in exercised and nonexercised limbs after concentric (CON) vs. eccentric (ECC) exercise of the forearm flexors. Twenty-five men (mean ± SD age, 23.6 ± 3.8 years; height, 179.7 ± 6.6 cm; body weight, 87.4 ± 14.6 kg) performed 6 sets of 10 maximal CON isokinetic (CON exercise) or ECC isokinetic (ECC exer...
Source: Journal of Strength and Conditioning Research - March 27, 2014 Category: Sports Medicine Tags: Original Research Source Type: research

Epidemiology and course of unipolar mania: results from the national epidemiologic survey on alcohol and related conditions (nesarc)
ConclusionsUM is an infrequent but clinically distinct subtype of bipolar I disorder. Further research delineating the characteristics of UM is warranted. (Source: Depression and Anxiety)
Source: Depression and Anxiety - March 27, 2014 Category: Psychiatry Authors: Ji Hyun Baek, Lori R. Eisner, Andrew A. Nierenberg Tags: Research Article Source Type: research

First stem cell model for bipolar disorder could lead to new treatments
It is unclear what causes bipolar disorder - a condition characterized by dramatic changes in mood. But researchers from the University of Michigan Medical School have created the first stem cell model for bipolar disorder, which they say could uncover the origins of the condition and open the door to new treatments.The research team recently published their study in the journal Translational Psychiatry.To reach their findings, the investigators obtained skin samples from people with bipolar disorder, alongside skin samples from individuals without the condition. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 26, 2014 Category: Consumer Health News Tags: Bipolar Source Type: news

Bipolar Disorder Benefits from Stem Cell Research
University of Michigan scientists have managed to create brain cells from embryonic-like stem cells that they have grown from individuals with bipolar disorder, and these brain cells are providing insight into some of the mysteries of the psychiatric condition. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - March 26, 2014 Category: Pharmaceuticals Source Type: news

Determination of serum lithium: comparison between atomic emission and absorption spectrometry methods
Conclusion: Both methods were considered satisfactory, precise and accurate and can be adopted for lithium quantification. In the comparison of quantitative results in lithium-treated patients through statistical tests, no significant differences were observed. Therefore the methods for lithium quantification by flame atomic absorption spectrometry (FAAS) and flame atomic emission spectrometry (FAES) may be considered similar. Introdução: A monitorização terapêutica por meio da determinação sérica de lítio é importante para proporcionar o ajuste individual da dose, como marcador de adesão e para prevenir intoxic...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 26, 2014 Category: Pathology Source Type: research

Anafranil / Clomipramine Side Effects
Catalogue of side effects for the medication Anafranil - generic Clomipramine - an antidepressant used in the treatment of obsessive compulsive disorder, self-injury, panic attacks, phobias, depression, migraines and other comorbid symptoms of bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 26, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Treatment for illegal drug use disorders: the role of comorbid mood and anxiety disorders
Conclusions: Individuals with an illegal drug use disorder and comorbid mood or anxiety disorders are disproportionately likely to report unmet need for treatment. Integrated mental health and substance use programs could prove effective in addressing their treatment needs. (Source: BMC Psychiatry - Latest articles)
Source: BMC Psychiatry - Latest articles - March 26, 2014 Category: Psychiatry Authors: Maria MelchiorElena ProkofyevaNadia YounèsPamela SurkanSilvia Martins Source Type: research

Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-L-cysteine analogue as a photochromic inhibitor
In this study, we synthesized a novel photochromic S-trityl-l-cysteine analogue, 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene (ACTAB), composed of a trityl group, azobenzene and N-acetyl-l-cysteine, which exhibits cis–trans photoisomerization in order to photocontrol the function of Eg5. ACTAB exhibited cis–trans photoisomerization upon alternating irradiation at two different wavelengths in the visible range, 400 and 480 nm. ACTAB induced reversible changes in the inhibitory activity of ATPase and motor activities correlating with the cis–tran...
Source: Journal of Biochemistry - March 26, 2014 Category: Biochemistry Authors: Ishikawa, K., Tohyama, K., Mitsuhashi, S., Maruta, S. Tags: Regular Papers Source Type: research

Efficacy of ECT in bipolar and unipolar depression in a real life hospital setting.
CONCLUSIONS: We did not find any difference in efficacy of ECT between the two forms of depression in real life setting. This calls for justification of use of ECT in all patients with depression irrespective of the type of illness polarity and inclusion of ECT as a routine treatment option in bipolar depression guidelines. PMID: 24655625 [PubMed - in process] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - March 25, 2014 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Stem cells offer clue to bipolar disorder treatment
Brain cells grown from the skin cells of people with bipolar disorder are revealing details about how it arises     (Source: New Scientist - Health)
Source: New Scientist - Health - March 25, 2014 Category: Consumer Health News Source Type: research

Production of Lithium Hydroxide from Lake Brines through Electro–Electrodialysis with Bipolar Membranes (EEDBM)
Industrial & Engineering Chemistry ResearchDOI: 10.1021/ie404334s (Source: Industrial and Engineering Chemical Research)
Source: Industrial and Engineering Chemical Research - March 25, 2014 Category: Chemistry Authors: Chenxiao Jiang, Yaoming Wang, Qiuyue Wang, Hongyan Feng and Tongwen Xu Source Type: research

Scientists Use Stem Cells to Study Bipolar Disorder
Approach may further understanding of this mental illness Source: HealthDay Related MedlinePlus Pages: Bipolar Disorder, Stem Cells (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 25, 2014 Category: Consumer Health News Source Type: news

First stem cell study of bipolar disorder yields promising results
What makes a person bipolar, prone to manic highs and deep, depressed lows? Why does bipolar disorder run so strongly in families, even though no single gene is to blame? And why is it so hard to find new treatments for a condition that affects 200 million people worldwide? New stem cell research may help scientists find answers to these questions. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 25, 2014 Category: Science Source Type: news

Social support in late life mania: GERI‐BD
ConclusionsIn late life mania, more social interaction with one's community appears to be associated with less severe symptoms at presentation for treatment, however, it can also be associated with slightly longer the duration of episode. Two aspects of the Duke Social Support Index are associated with a shorter episode duration prior to seeking treatment: being part of a larger family network and a having a higher level of instrumental support prior to treatment. The Instrumental Support Subscale measures the degree of assistance that is available for the respondent in performing daily tasks. These findings suggest that i...
Source: International Journal of Geriatric Psychiatry - March 25, 2014 Category: Geriatrics Authors: John L. Beyer, Rebecca L. Greenberg, Patricia Marino, Martha L. Bruce, Rayan K. Al Jurdi, Martha Sajatovic, Laszlo Gyulai, Benoit H. Mulsant, Ariel Gildengers, Robert C. Young Tags: Research Article Source Type: research

Response to Lithium in Bipolar Disorder: Clinical and Genetic Findings
ACS Chemical NeuroscienceDOI: 10.1021/cn5000277 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - March 25, 2014 Category: Neuroscience Authors: Janusz K. Rybakowski Source Type: research

First stem cell study of bipolar disorder yields promising results
(University of Michigan Health System) What makes a person bipolar, prone to manic highs and deep, depressed lows? Why does bipolar disorder run so strongly in families, even though no single gene is to blame? And why is it so hard to find new treatments for a condition that affects 200 million people worldwide? New stem cell research may help scientists find answers to these questions. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 25, 2014 Category: Biology Source Type: news

Buying Medications Online? Think Again
Most of the time, buying medications online just isn't safe. When the National Association of Boards of Pharmacy reviewed a large sample of online pharmacies, it found that only 3 percent were in compliance with U.S. pharmacy laws and practice standards. Worse yet, says the FDA, it isn't always easy to tell a fake site from one that is legitimate. The consequences of purchasing drugs over the internet can be serious. The FDA says, "The drugs you receive may look real, but they could be counterfeit, contaminated, expired or otherwise unsafe. If you receive counterfeit or substandard medicines, they could keep you from get...
Source: About.com Bipolar Disorder - March 25, 2014 Category: Psychiatry Source Type: news

Long‐term use of valproic acid in US veterans is associated with a reduced risk of smoking‐related cases of head and neck cancer
CONCLUSIONSUse of VPA is associated with a lower risk of developing head and neck cancers. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - March 24, 2014 Category: Cancer & Oncology Authors: Hyunseok Kang, Theresa W. Gillespie, Michael Goodman, Seth A. Brodie, Mina Brandes, Maria Ribeiro, Suresh S. Ramalingam, Dong M. Shin, Fadlo R. Khuri, Johann Christoph Brandes Tags: Original Article Source Type: research

Imaging Redox Activity at Bipolar Electrodes by Indirect Fluorescence Modulation
Analytical ChemistryDOI: 10.1021/ac500623v (Source: Analytical Chemistry)
Source: Analytical Chemistry - March 24, 2014 Category: Chemistry Authors: Laurent Bouffier, Thomas Doneux, Bertrand Goudeau and Alexander Kuhn Source Type: research

Construction of High Tg Bipolar Host Materials with Balanced Electron–Hole Mobility Based on 1,2,4-Thiadiazole for Phosphorescent Organic Light-Emitting Diodes
Chemistry of MaterialsDOI: 10.1021/cm403388s (Source: Chemistry of Materials)
Source: Chemistry of Materials - March 24, 2014 Category: Materials Science Authors: Jiangjiang Jin, Wenzhi Zhang, Bo Wang, Guanyuan Mu, Peng Xu, Lei Wang, Hong Huang, Jiangshan Chen and Dongge Ma Source Type: research

Mood-stabilizing drug could reduce risk of head and neck cancer
New research suggests that a commonly used mood-stabilizing drug - valproic acid - could help reduce the risk of developing head and neck cancer.The research team, led by Dr. Johann Christoph Brandes of the Atlanta Veterans Medical Center and Emory University in Atlanta, GA, recently published their findings in the journal Cancer.Valproic acid (VPA) is a medication used to treat epilepsy and manic-depressive illness, such as bipolar disorder. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 24, 2014 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Federal Register: Premarket Notification Submissions for Bipolar Electrosurgical Vessel Sealers for General Surgery; Draft Guidance for Industry and Food and Drug Administration Staff; Availability
The FDA is announcing the availability of the draft guidance entitled "Premarket Notification (510(k)) Submissions for Bipolar Electrosurgical Vessel Sealers for General Surgery.' FDA has developed this guidance document to assist industry in... (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - March 24, 2014 Category: Medical Equipment Source Type: news

Bipolar dislocation of the forearm (floating forearm).
We report a 28-year-old male patient who presented at another center with a history of a fall while climbing a tree. The patient's left elbow was treated with closed reduction and immobilization with a long-arm cast brace due to elbow dislocation. However, the patient was admitted with pain and swelling of the wrist to our emergency department the following day. Physical and radiological examination revealed dorsal trans-scaphoid perilunate dislocation. A dorsal incision was performed for open reduction and internal fixation to provide wide surgical exposure. Concomitant occurrence of elbow dislocation and fracture-disloca...
Source: Acta Orthopaedica et Traumatologica Turcica - March 24, 2014 Category: Orthopaedics Authors: Aşkar H, Ertürk C, Akif Altay M, Bilge A Tags: Acta Orthop Traumatol Turc Source Type: research

Relation of the Unipolar Low‐Voltage Penumbra Surrounding the Endocardial Low‐Voltage Scar to Ventricular Tachycardia Circuit Sites and Ablation Outcomes in Ischemic Cardiomyopathy
ConclusionIn ischemic cardiomyoapthy, unipolar LVA penumbra of varying size surrounds endocardial bipolar LVA, indicating intramural/epicardial scar. Although the size of this area did not predict early recurrence after endocardial ablation, frequent recurrences after VT ablation at scar periphery suggests deeper substrate toward the infarct border. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - March 24, 2014 Category: Cardiology Authors: NAGESH CHOPRA, MICHIFUMI TOKUDA, JUSTIN NG, TOBIAS REICHLIN, EYAL NOF, ROY M. JOHN, USHA B. TEDROW, WILLIAM G. STEVENSON Tags: Original Article Source Type: research

Volumetric R2* mapping using z‐shim multi‐echo gradient echo imaging
ConclusionThe proposed method improves R2* estimation, especially in the frontal and temporal regions. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - March 24, 2014 Category: Radiology Authors: Dongyeob Han, Yoonho Nam, Sung‐Min Gho, Dong‐Hyun Kim Tags: Note Source Type: research

Norepinephrine in Mental Illness
Norepinephrine - also known as noradrenaline - acts in more than one way in the human body. At moments of sudden stress, when adrenaline kicks in to give you extra energy, norepinephrine is at work as well. It also works as a neurotransmitter. More ... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Suicide risk factors in Iranian patients with bipolar disorder: A 21- month follow-up from BDPF study - Shabani A, Teimurinejad S, Kokar S, Ahmadzad Asl M, Shariati B, Mousavi Behbahani Z, Ghasemzadeh MR, Hasani S, Taban M, Shirekhoda S, Ghorbani Z, Tat S, Nohesara S, Shariat SV.
OBJECTIVE: Bipolar disorder is strongly associated with suicidal ideations, attempts and commissions. Although several studies have been conducted on suicide risk factors in patients with bipolar disorder worldwide, a comprehensive study has not been repor... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 22, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Differences in incidence of suicide attempts between bipolar I and II disorders and major depressive disorder - Holma KM, Haukka J, Suominen K, Valtonen HM, Mantere O, Melartin TK, Sokero TP, Oquendo MA, Isometsä ET.
OBJECTIVES: Whether risk of suicide attempts (SAs) differs between patients with bipolar disorder (BD) and patients with major depressive disorder (MDD) is unclear. We investigated whether cumulative risk differences are due to dissimilarities in time spen... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 22, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news