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Light-Controlled Biphasic Current Stimulator IC Using CMOS Image Sensors for High-Resolution Retinal Prosthesis and In Vitro Experimental Results With rd1 Mouse
Retinal prosthetic devices stimulate retinal nerve cells with electrical signals proportional to the incident light intensities. For a high-resolution retinal prosthesis, it is necessary to reduce the size of the stimulator pixels as much as possible, because the retinal nerve cells are concentrated in a small area of approximately $5, hbox{mm} times 5, hbox{mm}$. In this paper, a miniaturized biphasic current stimulator integrated circuit is developed for subretinal stimulation and tested in vitro. The stimulator pixel is miniaturized by using a complementary metal-oxide-semiconductor (CMOS) image sensor composed of three...
Source: IEEE Transactions on Biomedical Engineering - December 19, 2014 Category: Biomedical Engineering Source Type: research

809: Laser umbilical cord occlusion (UCO) in obligate lethal discordant anomalous monochorionic multiple gestations
We describe perinatal outcomes after laser UCO (L-UCO). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Jennifer King, Charlotte Conturie, Joseph Ouzounian, Lisa Korst, Arlyn Llanes, Ramen Chmait Tags: Poster session V Source Type: research

Total laparoscopic hysterectomy, vaginal hysterectomy and total abdominal hysterectomy using electrosurgical bipolar vessel sealing technique: a randomized controlled trial
Conclusion TLH had a longer operation time, yet, less blood loss, shorter hospital stay, less postoperative pain and fewer complications, compared to TAH and VH using EBVS. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - December 19, 2014 Category: OBGYN Source Type: research

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder
Advances in molecular genetics, fueled by the results of large‐scale genome‐wide association studies, meta‐analyses, and mega‐analyses, have provided the means of identifying genetic risk factors for human disease, thereby enriching our understanding of the functionality of the genome in the post‐genomic era. In the past half‐decade, research on neuropsychiatric disorders has reached an important milestone: the identification of susceptibility genes reliably associated with complex psychiatric disorders at genome‐wide levels of significance. This age of discovery provides the groundwork for follow‐up studie...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 19, 2014 Category: Genetics & Stem Cells Authors: Jonathan L. Hess, Thomas P. Quinn, Schahram Akbarian, Stephen J. Glatt Tags: Review Article Source Type: research

The longitudinal course of sleep timing and circadian preferences in adults with bipolar disorder
ConclusionsDisturbances of sleep timing are prominent in individuals with BP. These disturbances are worse during mood episodes, but still apparent during euthymic periods. Evening preference was not associated with polarity type, or mood state in BP, suggesting that this characteristic may be a trait marker. (Source: Bipolar Disorders)
Source: Bipolar Disorders - December 19, 2014 Category: Psychiatry Authors: Mohammad A Seleem, John A Merranko, Tina R Goldstein, Benjamin I Goldstein, David A Axelson, David A Brent, Vishwajit L Nimgaonkar, Rasim S Diler, Dara J Sakolsky, David J Kupfer, Boris Birmaher Tags: Original Article Source Type: research

Melanoma-associated retinopathy
Publication date: December 2014 Source:Taiwan Journal of Ophthalmology, Volume 4, Issue 4 Author(s): Chun-Hsiu Liu , Nan-Kai Wang , Ming-Hui Sun A 63-year-old Taiwanese man with a history of cutaneous melanoma presented with a rapid onset of bilateral shimmering light and blurred vision. A fundoscopic examination was normal. However, visual field examination indicated generalized depression in both eyes. Scotopic rod-specific electroretinography (ERG) was undetectable and scotopic maximal combined-cone and rod-specific ERG showed the characteristics of negative ERG (a normal a-wave and a diminished b-wave, with the b-wav...
Source: Taiwan Journal of Ophthalmology - December 19, 2014 Category: Opthalmology Source Type: research

Relationship of alcohol and cocaine on mood episodes among HIV-infected adults with bipolar disorder and major depressive disorder
This study examined the weekly associations between mood episodes and substance use over a 12-week period. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - December 18, 2014 Category: Addiction Authors: Lakia J. King, Mary D. Key, Sheri Towe, Christina S. Meade Source Type: research

Pharmacokinetic–pharmacodynamic analyses in the assessment of abuse-deterrent opioid formulations
Aims: ADFs are being developed to mitigate opioid abuse while maintaining patient access to safe and effective analgesic therapy. It is generally expected that reducing and delaying peak opioid agonist concentration (Cmax) reduces abuse potential. To evaluate the utility of PK in assessing abuse deterrence, this exploratory analysis focused on the relationship between PK and subjective PD measures (e.g., bipolar Drug Liking visual analog scale) commonly used in human abuse potential (HAP) studies. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - December 18, 2014 Category: Addiction Authors: Megan Shram, Salvatore Colucci, Stephen Harris, Peter J. Perrino, Kerri A. Schoedel, Naama Levy-Cooperman, Sharon L. Walsh Source Type: research

[New insights into ways of determining cortisol exposure in patients with bipolar disorder.]
CONCLUSION: The use of hair analysis to measure mean cortisol levels over long periods seems to give added value to the hpa-axis tests currently used for measuring cortisol exposure. The technique may make it easier to differentiate between various subtypes of bipolar disorder. PMID: 25510453 [PubMed - as supplied by publisher] (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - December 18, 2014 Category: Psychiatry Authors: Spijker AT, Staufenbiel SM, van Rossum EF Tags: Tijdschr Psychiatr Source Type: research

Causes, Signs and Consequences of Low...
Many people who have bipolar disorder struggle with low self-esteem. So how do we get it and how do we end the struggle? (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - December 18, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Effects of erythropoietin on hippocampal volume and memory in mood disorders
Persistent cognitive dysfunction in depression and bipolar disorder (BD) impedes patients’ functional recovery. Erythropoietin (EPO) increases neuroplasticity and reduces cognitive difficulties in treatment-resistant depression (TRD) and remitted BD. This magnetic resonance imaging (MRI) study assessed the neuroanatomical basis for these effects. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 18, 2014 Category: Psychiatry Authors: Kamilla W. Miskowiak, Maj Vinberg, Julian Macoveanu, Hannelore Ehrenreich, Nicolai Køster, Becky Inkster, Olaf B. Paulson, Lars V. Kessing, Arnold Skimminge, Hartwig R. Siebner Source Type: research

Prescribing of antipsychotics in UK primary care: a cohort study
Conclusions In UK primary care, a large proportion of people prescribed antipsychotics have no record of psychotic or bipolar disorder. They are often older people with conditions including dementia, non-psychotic depression, anxiety and sleep disorders. (Source: BMJ Open)
Source: BMJ Open - December 18, 2014 Category: Journals (General) Authors: Marston, L., Nazareth, I., Petersen, I., Walters, K., Osborn, D. P. J. Tags: Open access, Press releases, Epidemiology, General practice / Family practice, Mental health Research Source Type: research

Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls.
CONCLUSION: Our results support the role of the amygdala-vlPFC as the system of dysfunctional contextual affective processing in patients with BD. Opposite amygdala reactivity unmasked by the mood challenge paradigm could represent a trait marker of altered mood regulation in patients with BD. PMID: 25510947 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 17, 2014 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Comparative neuropsychiatry: White matter abnormalities in children and adolescents with schizophrenia, bipolar affective disorder, and obsessive-compulsive disorder.
CONCLUSIONS: White matter abnormalities in early-onset schizophrenia and bipolar affective disorder are more global in nature, whereas children and adolescents with obsessive-compulsive disorder do not show widespread differences in FA. PMID: 25498242 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - December 17, 2014 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Influence of birth cohort on age of onset cluster analysis in bipolar I disorder.
CONCLUSION: These results using international data confirm prior findings using single country data, that there are subgroups of bipolar I disorder based on the age of onset, and that there is a birth cohort effect. Including the birth cohort adjustment altered the number and characteristics of subgroups detected when clustering by age of onset. Further investigation is needed to determine if combining both approaches will identify subgroups that are more useful for research. PMID: 25498240 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - December 17, 2014 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Brain functional changes across the different phases of bipolar disorder.
Conclusions Bipolar disorder is characterised by mood state-dependent hypoactivation in the parietal cortex. Reduced dorsolateral prefrontal activation is a further feature of mania and depression, which may improve partially in euthymia. Failure of de-activation in the medial frontal cortex shows trait-like characteristics. PMID: 25497296 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - December 17, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Interventions for Sleep Disturbance in Bipolar Disorder
Bipolar disorder is a severe and chronic disorder, ranked in the top 10 leading causes of disability worldwide. Sleep disturbances are strongly coupled with interepisode dysfunction and symptom worsening in bipolar disorder. Experimental studies suggest that sleep deprivation can trigger manic relapse. There is evidence that sleep deprivation can have an adverse impact on emotion regulation the following day. The clinical management of the sleep disturbances experienced by bipolar patients, including insomnia, hypersomnia delayed sleep phase, and irregular sleep-wake schedule, may include medication approaches, psychologic...
Source: Sleep Medicine Clinics - December 17, 2014 Category: Sleep Medicine Authors: Allison G. Harvey, Katherine A. Kaplan, Adriane M. Soehner Source Type: research

Alcohol withdrawal delirium manifested by manic symptoms in an elderly patient
Abstract Alcohol withdrawal syndrome is a commonly seen problem in psychiatric practice. Alcohol withdrawal delirium is associated with significant morbidity and mortality. Withdrawal symptoms usually include tremulousness, psychotic and perceptual symptoms, seizures, and consciousness disturbance. Herein, we report a case involving a 63‐year‐old man who had alcohol withdrawal delirium that was manifested mainly by manic symptoms. (Source: Psychogeriatrics)
Source: Psychogeriatrics - December 17, 2014 Category: Geriatrics Authors: Hung‐Yu Chan, Kuan‐I Lee Tags: CASE REPORT Source Type: research

Myelin vs Axon Abnormalities in White Matter in Bipolar Disorder
oldbach & Fei Du Keywords: (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - December 17, 2014 Category: Neurology Authors: Kathryn E LewandowskiDost OngürSarah H SperryBruce M CohenSelma SehovicJacqueline R GoldbachFei Du Source Type: research

Cone bipolar cells in the retina of the microbat Carollia perspicillata
This article is protected by copyright. All rights reserved. Graphical abstract ‐text Using intracellular DiI injections and immunolabeling, seven cone bipolar cell types are identified in the retina of a microchiropteran bat. In contrast to the traditional view, the strongly nocturnal microbats recently have been shown to possess some retinal prerequisites for cone‐based vision in addition to rod‐based vision. The presence of several cone bipolar cell types strengthens the conclusion that the microbat retina largely conforms to the general mammalian pattern of complex cone pathways. Graphical abstract ‐legend Dye...
Source: The Journal of Comparative Neurology - December 17, 2014 Category: Neurology Authors: Elisabeth Butz, Leo Peichl, Brigitte Müller Tags: Research Article Source Type: research

IL-23 and TGF-β1 levels as potential predictive biomarkers in treatment of bipolar I disorder with acute manic episode
This study aimed to explore the relationship between inflammatory cytokines—especially regulatory factors and the effect of combination treatment—with quetiapine and lithium in manic patients. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - December 17, 2014 Category: Neurology Authors: Haozhe Li, Wu Hong, Chen Zhang, Zhiguo Wu, Zuowei Wang, Chenmei Yuan, Zezhi Li, Jia Huang, Zhiguang Lin, Yiru Fang Tags: Research report Source Type: research

Cognitive performances associate with measures of white matter integrity in bipolar disorder
Neuropsychological deficits constitute enduring trait-like features in bipolar disorder (BD), and persist in euthymia. White matter (WM) abnormalities are one of the most consistently reported findings in neuroimaging studies of BD. We hypothesised that neuropsychological performances could correlate with WM integrity in a sample of bipolar patients in core WM tracts. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - December 17, 2014 Category: Neurology Authors: Sara Poletti, Irene Bollettini, Elena Mazza, Clara Locatelli, Daniele Radaelli, Benedetta Vai, Enrico Smeraldi, Cristina Colombo, Francesco Benedetti Tags: Research report Source Type: research

Multiple sclerosis and psychiatric disorders: Comorbidity and sibling risk in a nationwide Swedish cohort
Conclusion: We found a strong positive association between MS and bipolar disorder and depression that could not be explained by genetic liability. The unexpected negative association between MS and schizophrenia might be spurious or indicate possible protective mechanisms that warrant further exploration. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 17, 2014 Category: Neurology Authors: Johansson, V., Lundholm, C., Hillert, J., Masterman, T., Lichtenstein, P., Landen, M., Hultman, C. M. Tags: Research Papers Source Type: research

The Most Exciting Health Stories Of 2014
While 2014 will forever be known as the year of the world's biggest Ebola outbreak -- and the first cases of Ebola contracted in the United States -- the virus is just one of several impactful changes in our medical and personal health landscape. From cancer research breakthroughs to innovative food policies to strides in the search for an HIV vaccine, we're quite a bit further in our understanding of medicine than we were last year. Thanks to research in 2014... Your Fitness Tracker Data Could Lead To The Next Big Medical Discovery Your FitBit, Jawbone and other personal tracking devices and apps are logging every s...
Source: Science - The Huffington Post - December 16, 2014 Category: Science Source Type: news

The relationship between lifetime suicide attempts, serum lipid levels, and metabolic syndrome in patients with bipolar disorders
International Journal of Psychiatry in Clinical Practice, Ahead of Print. (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - December 16, 2014 Category: Psychiatry Tags: article Source Type: research

Selective reading of large online forum discussions: The impact of rating visualizations on navigation and learning
Publication date: March 2015 Source:Computers in Human Behavior, Volume 44 Author(s): Jürgen Buder , Christina Schwind , Anja Rudat , Daniel Bodemer As discussions in online forums can become quite large, participants must be highly selective in their reading behavior. Standard, chronological displays of discussions provide little guidance in how to find valuable content. An experimental study tested whether a group awareness tool can support individual navigation and subsequent learning within a forum. 127 participants read through a large online discussion in which contributions were rated on average quality and avera...
Source: Computers in Human Behavior - December 16, 2014 Category: Information Technology Source Type: research

Electrical Storm Induced by Cardiac Resynchronization Therapy Is Determined by Pacing on Epicardial Scar and Can be Successfully Managed by Catheter Ablation [Original Articles]
Conclusions— CRT-induced proarrhythmia presented early with electrical storm and was associated with an LV lead positioning within epicardial scar. Catheter ablation allowed for resumption of biventricular stimulation in all patients. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 16, 2014 Category: Cardiology Authors: Roque, C., Trevisi, N., Silberbauer, J., Oloriz, T., Mizuno, H., Baratto, F., Bisceglia, C., Sora, N., Marzi, A., Radinovic, A., Guarracini, F., Vergara, P., Sala, S., Paglino, G., Gulletta, S., Mazzone, P., Cireddu, M., Maccabelli, G., Della Bella, P. Tags: Congestive, Ablation/ICD/surgery, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Relationship Between Catheter Contact Force and Radiofrequency Lesion Size and Incidence of Steam Pop in the Beating Canine Heart: Electrogram Amplitude, Impedance, and Electrode Temperature Are Poor Predictors of Electrode-Tissue Contact Force and Lesion Size [Original Articles]
Conclusions— Radiofrequencylesion size and the incidence of steam pop increase strikingly with increasing CF. Electrogram parameters and initial impedance are poor predictors of CF for radiofrequency ablation. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - December 16, 2014 Category: Cardiology Authors: Ikeda, A., Nakagawa, H., Lambert, H., Shah, D. C., Fonck, E., Yulzari, A., Sharma, T., Pitha, J. V., Lazzara, R., Jackman, W. M. Tags: Ablation/ICD/surgery, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Bipolar Disorder - How Often Do People Cycle?
A cycle is the period of time an individual takes to go through one episode of mania and one of depression (or hypomania and depression). (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - December 16, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

How Long Will It Take to Get Disability Benefits?
To get disability benefits your medical condition(s) must have lasted, or be expected to last, at least one year or be expected to result in your death. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - December 16, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Serum uric acid levels and different phases of illness in bipolar I patients treated with lithium
Recent findings support the role of purinergic system dysfunction in the pathophysiology of bipolar disorder (BD). The present study aimed to evaluate the pattern of serum uric acid levels in a sample of 98 BD I patients followed-up prospectively in a naturalistic study and treated with lithium monotherapy or in association with other mood stabilizers (valproate or carbamazepine), in relation to different phases of illness and to pharmacological treatment. The results showed that uric acid levels were significantly higher in patients suffering from a manic/mixed episode, than in those euthymic or during a depressive phase....
Source: Psychiatry Research - December 16, 2014 Category: Psychiatry Authors: Matteo Muti, Claudia Del Grande, Laura Musetti, Donatella Marazziti, Milo Turri, Marco Cirronis, Irene Pergentini, Martina Corsi, Liliana Dell'Osso, Giovanni Umberto Corsini Source Type: research

Post‐tonsillectomy haemorrhage rates are related to technique for dissection and for haemostasis. An analysis of 15734 patients in the National Tonsil Surgery Register in Sweden
ConclusionsAll hot techniques resulted in a higher risk for late PTH compared with cold steel dissection +cold haemostasis. The risk for RTT was higher for all hot techniques except for coblation, while ultrascision resulted in a lower risk for early PTH. An early PTH was associated with an increased risk for late PTH.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - December 16, 2014 Category: ENT & OMF Authors: Anne‐Charlotte Hessén Söderman, Erik Odhagen, Elisabeth Ericsson, Claes Hemlin, Elisabeth Hultcrantz, Ola Sunnergren, Joacim Stalfors Tags: Original Manuscript Source Type: research

Disability in bipolar I disorder: The 36-item world health organization disability Assessment schedule 2.0
The WHODAS 2.0 is an ICF-based multidimensional instrument developed for measuring disability. The present study analyzes the utility of the 36-item interviewer-administered version in a sample of patients with bipolar disorder. There is no study to date that analyses how the scale works in a sample that only comprises such patients. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - December 16, 2014 Category: Neurology Authors: Georgina Guilera, Juana Gómez-Benito, Óscar Pino, Emilio Rojo, Eduard Vieta, Manuel J. Cuesta, Scot E. Purdon, Miguel Bernardo, Benedicto Crespo-Facorro, Manuel Franco, Anabel Martínez-Arán, Gemma Safont, Rafael Tabarés-Seisdedos, Javier Rejas, for t Tags: Research report Source Type: research

Microstructural abnormalities in anterior callosal fibers and their relationship with cognitive function in major depressive disorder and bipolar disorder: A tract-specific analysis study
The corpus callosum modulates interhemispheric communication and cognitive processes. It has been suggested that white matter abnormalities in the corpus callosum are related to the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). The aim of this study was to examine microstructural abnormalities in callosal fibers separated by their connection to functional brain regions and determine the relationship of these abnormalities with cognitive function in MDD and BD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - December 16, 2014 Category: Neurology Authors: Shinichi Yamada, Shun Takahashi, Satoshi Ukai, Tomikimi Tsuji, Jun Iwatani, Kumi Tsuda, Akira Kita, Yuka Sakamoto, Masahiro Yamamoto, Masaki Terada, Kazuhiro Shinosaki Tags: Research report Source Type: research

Effects of testosterone therapy on bipolar disorder with Klinefelter syndrome
We present the case of an 18-year-old man with KS who experienced rapidly repeating relapses of manic episodes. He was unresponsive to the usual pharmacotherapies for bipolar disorders such as mood stabilizers and second-generation antipsychotics. Mood was eventually improved with testosterone therapy in addition to pharmacotherapy, with no relapse of manic episodes for 3 years after discharge. (Source: General Hospital Psychiatry)
Source: General Hospital Psychiatry - December 16, 2014 Category: Psychiatry Authors: Kazuhiro Kawahara, Tadashi Jono, Yoshitomo Nishi, Hirokage Ushijima, Manabu Ikeda Source Type: research

Pro and Con: The British Psychological Society Report on Psychosis
The original etymologies and current usages of the words "psychosis" and "neurosis" are confusingly topsy-turvy. "Psychosis" literally means a disease of the soul or mind, but for more than 100 years this term has been used to describe only the severest forms of mental disorders, those that have at least partial causality in neurological (brain) malfunction. "Neurosis" literally means a disease of the nerves, but for more than 200 years this term has been used to describe a grab bag of mostly milder mental disorders more clearly related to psychology (the mind) or to social pressures than to any neurological disease. Re...
Source: Healthy Living - The Huffington Post - December 15, 2014 Category: Consumer Health Advice Source Type: news

Pro and Con: The British Psychological Society Report on Psychosis
The original etymologies and current usages of the words "psychosis" and "neurosis" are confusingly topsy-turvy. "Psychosis" literally means a disease of the soul or mind, but for more than 100 years this term has been used to describe only the severest forms of mental disorders, those that have at least partial causality in neurological (brain) malfunction. "Neurosis" literally means a disease of the nerves, but for more than 200 years this term has been used to describe a grab bag of mostly milder mental disorders more clearly related to psychology (the mind) or to social pressures than to any neurological disease. Re...
Source: Science - The Huffington Post - December 15, 2014 Category: Science Source Type: news

Two Years to Nowhere
Two years after Newtown, mental health still matters, and most people still don't care. This weekend, on the second anniversary of the Newtown shootings, I took my daughter to see her first performance of The Nutcracker. Unsure of the exact venue, we parked on the street and followed the hordes of blond girls dressed just like my daughter in velvet dresses with satin sashes. I have wanted to reenact this holiday tradition from my childhood with my own now 9-year-old for many years. But this year was the first time we could actually go together. Two years ago, her brother was in an acute care psychiatric hospital, and I sh...
Source: Healthy Living - The Huffington Post - December 15, 2014 Category: Consumer Health Advice Source Type: news

Depression: Discrete or Continuous
Elucidating the true structure of depression is necessary if we are to advance our understanding and treatment options. Central to the issue of structure is whether depression represents discrete types or occurs on a continuum. Nature almost universally operates on the basis of continuums, whereas human perception favors discrete categories. This reality might be formalized into a ‘continuum principle': natural phenomena tend to occur on a continuum, and any instance of hypothesized discreteness requires unassailable proof. Research evidence for discrete types falls far short of this standard, with most evidence supporti...
Source: Psychopathology - December 15, 2014 Category: Psychiatry & Psychology Source Type: research

Brain Imaging Findings Shed Light on Suicidal BehaviorBrain Imaging Findings Shed Light on Suicidal Behavior
Deficits in frontal brain systems may be associated with risk for suicide attempts in young people with bipolar disorder. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - December 15, 2014 Category: Psychiatry Tags: Psychiatry News Source Type: news

Ventral Anterior Cingulate Connectivity Distinguished Nonpsychotic Bipolar Illness From Psychotic Bipolar Disorder and Schizophrenia
Bipolar illness is a debilitating neuropsychiatric disorder associated with alterations in the ventral anterior cingulate cortex (vACC), a brain region thought to regulate emotional behavior. Although recent data-driven functional connectivity studies provide evidence consistent with this possibility, the role of vACC in bipolar illness and its pattern of whole brain connectivity remain unknown. Furthermore, no study has established whether vACC exhibits differential whole brain connectivity in bipolar patients with and without co-occurring psychosis and whether this pattern resembles that found in schizophrenia. We conduc...
Source: Schizophrenia Bulletin - December 15, 2014 Category: Psychiatry Authors: Anticevic, A., Savic, A., Repovs, G., Yang, G., McKay, D. R., Sprooten, E., Knowles, E. E., Krystal, J. H., Pearlson, G. D., Glahn, D. C. Tags: Regular Article Source Type: research

Correlations Between Brain Structure and Symptom Dimensions of Psychosis in Schizophrenia, Schizoaffective, and Psychotic Bipolar I Disorders
Conclusions: Structural measures correlate with positive and negative symptom severity in psychotic disorders. Cortical thickness demonstrated more associations with psychopathology than cortical surface area. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - December 15, 2014 Category: Psychiatry Authors: Padmanabhan, J. L., Tandon, N., Haller, C. S., Mathew, I. T., Eack, S. M., Clementz, B. A., Pearlson, G. D., Sweeney, J. A., Tamminga, C. A., Keshavan, M. S. Tags: Regular Article Source Type: research

Hippocampal Volume Is Reduced in Schizophrenia and Schizoaffective Disorder But Not in Psychotic Bipolar I Disorder Demonstrated by Both Manual Tracing and Automated Parcellation (FreeSurfer)
This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual ...
Source: Schizophrenia Bulletin - December 15, 2014 Category: Psychiatry Authors: Arnold, S. J. M., Ivleva, E. I., Gopal, T. A., Reddy, A. P., Jeon-Slaughter, H., Sacco, C. B., Francis, A. N., Tandon, N., Bidesi, A. S., Witte, B., Poudyal, G., Pearlson, G. D., Sweeney, J. A., Clementz, B. A., Keshavan, M. S., Tamminga, C. A. Tags: Regular Article Source Type: research

Left-Dominant Temporal-Frontal Hypercoupling in Schizophrenia Patients With Hallucinations During Speech Perception
Conclusions: These findings replicate our previous work showing generalized speech-related functional network hypercoupling in schizophrenia during inner verbal thought and SP, but extend them by suggesting that hypercoupling is related to past-week hallucination severity scores during SP only, when control over verbal material is not required. This result opens the possibility that practicing control over inner verbal thought processes may decrease the likelihood or severity of hallucinations. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - December 15, 2014 Category: Psychiatry Authors: Lavigne, K. M., Rapin, L. A., Metzak, P. D., Whitman, J. C., Jung, K., Dohen, M., L{oelig}venbruck, H., Woodward, T. S. Tags: Regular Article Source Type: research

Adeno-associated virus-RNAi of GlyR{alpha}1 and characterization of its synapse-specific inhibition in OFF alpha transient retinal ganglion cells
In the central nervous system, inhibition shapes neuronal excitation. In spinal cord glycinergic inhibition predominates, whereas GABAergic inhibition predominates in the brain. The retina uses GABA and glycine in approximately equal proportions. Glycinergic crossover inhibition, initiated in the On retinal pathway, controls glutamate release from presynaptic OFF cone bipolar cells (CBCs) and directly shapes temporal response properties of OFF retinal ganglion cells (RGCs). In the retina, four glycine receptor (GlyR) α-subunit isoforms are expressed in different sublaminae and their synaptic currents differ in decay ...
Source: Journal of Neurophysiology - December 15, 2014 Category: Neurology Authors: Zhang, C., Rompani, S. B., Roska, B., McCall, M. A. Tags: Neural Circuits Source Type: research

The impact of cognitive impairment, neurological soft signs and subdepressive symptoms on functional outcome in bipolar disorder
Cognitive impairments and subsyndromal depressive symptoms are present during euthymic periods of bipolar disorder (BD). Most studies have determined that cognitive impairments and residual depressive symptoms have major impacts on psychosocial functioning. The aim of the present study was to identify the major factor responsible for low psychosocial functioning in a subgroup of patients with BD despite clinical recovery. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - December 15, 2014 Category: Neurology Authors: Tuba Öcek Baş, Cana Aksoy Poyraz, Alper Baş, Burç Çağrı Poyraz, Musa Tosun Tags: Research report Source Type: research

Prevalence and predictors of bipolar disorders in patients with a major depressive episode: The Japanese epidemiological trial with latest measure of bipolar disorder (JET-LMBP)
This study, conducted in clinical settings in Japan, examines patients with a major depressive episode to investigate the prevalence and predictors of bipolar disorders. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - December 15, 2014 Category: Neurology Authors: Takeshi Inoue, Yoshifumi Inagaki, Toshifumi Kimura, Osamu Shirakawa Tags: Research report Source Type: research

The Prestige Model of Spectrum Bipolarity
Because affective pathogenesis is a hard problem for psychiatry, it behoves researchers to develop and test novel models of causality. We examine the notion that the adaptive drive to social investment – prestige - provides clues to the bipolar spectrum. A seven node bipolar spectrum is proposed, based on a putatative gradient of “bipolarity”. It is conceived that this gradient may correlate with the drive to social investment (prestige). In order to test this hypothesis with proof of concept data, a case control study categorised 228 subjects into a seven node bipolar spectrum. (Source: Medical Hypotheses)
Source: Medical Hypotheses - December 15, 2014 Category: Biomedical Science Authors: James Le Bas, Richard Newton, Rachel Sore, David Castle Source Type: research

27. Prognostic role of spectral analysis of the EEG in premature infants
Brain maturation at early stages may be assessed by changes in spectral power frequencies of electroencephalogram (EEG) (Scher et al., 1997), but their predictive value for later outcome remains poorly understood. The aim of this study is to correlate neonatal spectral power values with developmental scores obtained at one year in infants born premature. EEG was recorded on twenty infants (23–34weeks) at 35 post-conceptional weeks. In order to minimize handling, one bipolar channel (C3-C4) was recorded. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: M. Sole, E. Cainelli, A. Cappellari, P.S. Bisiacchi, A. Suppiej Source Type: research

Improved implant and postoperative lead performance in CRT-D patients implanted with a quadripolar left ventricular lead. A 6-month follow-up analysis from a multicenter prospective comparative study
Conclusions This multicenter study demonstrates that the use of a quadripolar LV lead results in significantly lower rates of lead-related problems and reduced procedural and fluoroscopic times for biventricular system implantation. This has important implications for LV pacing lead choice. (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - December 13, 2014 Category: Cardiology Source Type: research