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Retro Report: Debate Persists Over Diagnosing Mental Health Disorders, Long After ‘Sybil’
Bipolar disorder or attention deficit hyperactivity disorder has been diagnosed in millions of Americans, but is that a result of more expert diagnosis, or simply too frequent diagnosis? (Source: NYT Health)
Source: NYT Health - November 24, 2014 Category: Consumer Health News Authors: By CLYDE HABERMAN Tags: Mental Health and Disorders Shirley Ardell Mason Sybil Psychiatry and Psychiatrists Multiple Personalities Dr. Cornelia B. Wilbur Source Type: news

Placebos Can Work - Even When Patients Know...
Astonishing results from a Harvard study showed that placebos worked even when patients knew what they were taking. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar Teen - Insights on Doctors, Meds and...
Interview with a 14-year-old boy who has bipolar disorder. Zach discussed seeing a psychiatrist, how he feels about taking meds, and what makes him angry. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Delusions of Paranoia and Persecution
Delusions of paranoia and persecution can occur during bipolar mania and depression. Here, four people tell their own experiences with such delusions. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Essential Information About Seroquel (Quetiapine)
Essential information about Seroquel (quetiapine), an antipsychotic medication used to treat psychotic symptoms and bipolar depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Characterization of dsRed2-positive cells in the doublecortin-dsRed2 transgenic adult rat retina
In this study, we characterize dsRed2 reporter protein-expressing cells in the adult retina of the transgenic DCX promoter-dsRed2 rat model, with the aim to identify cells with putative neurogenic activity. Additionally, we confirmed the expression of the dsRed2 protein in DCX-expressing cells in the adult hippocampal dentate gyrus. Adult DCX-dsRed2 rat retinas were analyzed by immunohistochemistry for expression of DCX, NF200, Brn3a, Sox2, NeuN, calbindin, calretinin, PKC-a, Otx2, ChAT, PSA-NCAM and the glial markers GFAP and CRALBP, followed by confocal laser-scanning microscopy. In addition, brain sections of transgenic...
Source: Histochemistry and Cell Biology - November 22, 2014 Category: Biomedical Science Source Type: research

Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses? - Busse M, Busse S, Myint AM, Gos T, Dobrowolny H, Müller UJ, Bogerts B, Bernstein HG, Steiner J.
Disturbances of glutamatergic neurotransmission and mononuclear phagocyte system activation have been described uni- and bipolar depression (UD/BD). Linking the glutamate and immune hypotheses of depression, quinolinic acid (QUIN) is synthesized by activat... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 22, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder - Youssef NA, Bradford DW, Kilts JD, Szabo ST, Naylor JC, Allen TB, Strauss JL, Hamer RM, Brunca M, Shampine LJ, Marx CE.
BACKGROUND: Clozapine and lithium increase neurosteroids in rodents, and both drugs demonstrate antisuicidal actions. We therefore hypothesized that neurosteroid levels may be reduced in patients with schizophrenia or bipolar disorder who completed suicide... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 22, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

The relationship between lifetime suicide attempts, serum lipid levels, and metabolic syndrome in patients with bipolar disorders - Shakeri J, Farnia V, Valinia K, Hashemian AH, Bajoghli H, Holsboer-Trachsler E, Brand S.
OBJECTIVES: To assess the relationship between lifetime suicide attempts (SA), serum lipid values, and metabolic syndrome (MetS) in patients with bipolar disorders (BPD). METHODS: Eighty patients with BPD took part in the study (M=40.60 years). Aft... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 22, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Recent Progress in Radiofrequency Ablation Therapy for Hepatocellular Carcinoma
In order to attain better ablation and more effective management of hepatocellular carcinoma (HCC), new approaches and devices in radiofrequency ablation (RFA) therapy were presented and discussed in a workshop at the 50th Annual Meeting of the Liver Cancer Study Group of Japan. A novel bipolar RFA apparatus was introduced in Japan in January 2013. Hundreds of subjects with HCC were treated with multipolar RFA with varied devices and plans. Among these, no-touch ablation was one of the most useful procedures in the treatment of HCC with the apparatus. In RFA therapy, a few assisting devices and techniques were applied for ...
Source: Oncology - November 22, 2014 Category: Cancer & Oncology Source Type: research

A short-term evaluation of the safety and the efficacy of bipolar transurethral resection of the prostate in patients with a large prostate (>90g)
Conclusion Bipolar technology makes it possible to use TURP to treat patients with very large prostates and who are at risk when treated by the standard monopolar technology, with a satisfactory safety profile and with favourable efficacy. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - November 22, 2014 Category: Urology & Nephrology Source Type: research

Predominant polarity in bipolar disorder and validation of the polarity index in a German sample
Conclusion: The reason for this negative finding might well be that for several drugs, which were used frequently, no PI value is available. Nevertheless we suggest PP as an important concept in the planning of BD maintenance treatment. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - November 22, 2014 Category: Epidemiology Authors: Julia VolkertKathrin C ZierhutMiriam A SchieleMartina WenzelJuliane KopfSarah Kittel-SchneiderAndreas Reif Source Type: research

Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats
Publication date: Available online 21 November 2014 Source:Journal of Psychiatric Research Author(s): Roger B. Varela , Samira S. Valvassori , Jéssica Lopes-Borges , Edemilson Mariot , Gustavo C. Dal-Pont , Rafaela T. Amboni , Guilherme Bianchini , João Quevedo Bipolar Disorder (BD) is one of the most severe psychiatric disorders. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on manic-like behaviors. Neurotrophins have been considered important mediators in the p...
Source: Journal of Psychiatric Research - November 22, 2014 Category: Psychiatry Source Type: research

Interparental violence and maternal mood disorders as predictors of adolescent physical aggression within the family
This study examined levels of physical IPV perpetration and victimization in mothers with unipolar depression or Bipolar Disorder (BD) and the processes by which maternal physical IPV moderated adolescents' physical aggression in families with maternal mood disorders. Mothers with lifetime mood disorders were predicted to have elevated IPV compared to well mothers, and maternal IPV was expected to moderate the association between lifetime mood disorders and adolescent aggression. Participants included 61 intact families with maternal depression (n = 24), BD (n = 13), or well mothers (n = 24) and two siblings (a...
Source: Aggressive Behavior - November 22, 2014 Category: Psychiatry & Psychology Authors: Angela J. Narayan, Muzi Chen, Pedro P. Martinez, Philip W. Gold, Bonnie Klimes‐Dougan Tags: Research Article Source Type: research

Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans
Publication date: Available online 22 November 2014 Source:International Journal of Psychophysiology Author(s): Aleksandar Kalauzi , Aleksandra Vuckovic , Tijana Bojić Organization of resting state cortical networks is of fundamental importance for the phenomenon of awareness, which is altered in the first part of hypnagogic period (Hori stages 1–4). Our aim was to investigate the change in brain topography pattern of EEG alpha attractor correlation dimension (CD) in the period of transition from Hori stage 1 to 4. EEG of ten healthy adult individuals was recorded in the wake and drowsy states, using a 14 channel aver...
Source: International Journal of Psychophysiology - November 22, 2014 Category: Psychiatry & Psychology Source Type: research

Treatment Moderators of Child- and Family-Focused Cognitive-Behavioral Therapy for Pediatric Bipolar Disorder
Prior work has demonstrated the efficacy of child- and family-focused cognitive-behavioral therapy (CFF-CBT) versus enhanced treatment as usual (TAU; unstructured psychotherapy) for pediatric bipolar disorder (PBD). The current study builds on primary findings by examining baseline child, parent, and family characteristics as moderators of symptom response trajectories. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - November 22, 2014 Category: Psychiatry Authors: Sally M. Weinstein, David Henry, Andrea Katz, Amy T. Peters, Amy E. West Source Type: research

Insight in bipolar disorder: a systematic review
Conclusion Insight is greatly impaired in BD, especially during mania. Several clinical factors seem to influence the level of insight. (Source: Jornal Brasileiro de Psiquiatria)
Source: Jornal Brasileiro de Psiquiatria - November 21, 2014 Category: Psychiatry Source Type: research

Choosing Mania or Depression Without Disorder
Do you have bipolar disorder or know somebody who does? What would change if you could learn how to turn depression and mania on and off whenever you wanted to? The entire way we look at bipolar disorder would change in profound ways. Some are beyond most people’s imagination, but a simple illustration will help you to see why some of us say bipolar is an advantage.read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - November 21, 2014 Category: Psychiatry & Psychology Authors: Tom Wootton Tags: Depression Evolutionary Psychology Psychiatry Self-Help bipolar disorder Bipolar in order mania mood disorders Tom Wootton Source Type: news

C11: Restoring long term spontaneous voiding in prostate cancer related urinary retention – Bipolar plasma vaporization, a palliative therapeutic approach
Publication date: November 2014 Source:European Urology Supplements, Volume 13, Issue 6 Author(s): B. Geavlete , F. Stanescu , G. Nita , C. Moldoveanu , M. Jecu , C. Ene , C. Bulai , P. Geavlete (Source: European Urology Supplements)
Source: European Urology Supplements - November 21, 2014 Category: Urology & Nephrology Source Type: research

Risperdal (Risperidone) - What You Need to Know
Essential information about Risperdal - generic risperidone - an antipsychotic medication approved to treat several mental disorders, including bipolar. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Consideration on bipolar manio-depressive disease and the effect of Lithium. A neurophysiological view on mental disorders
Publication date: Available online 20 November 2014 Source:Journal of Psychiatric Research Author(s): Jens Chr. Skou (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 21, 2014 Category: Psychiatry Source Type: research

A genome-wide association study of suicide severity scores in bipolar disorder
Conclusions Our GWAS findings suggest that likely many gene variants of small effects contribute collectively to the risk for suicidal behaviour severity in BD. Larger independent replications are required to strengthen the findings from the GWAS presented here. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 21, 2014 Category: Psychiatry Source Type: research

Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine
Publication date: 15 August 2011 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 35, Issue 7 Author(s): Raquel Levin , Mariana Bendlin Calzavara , Camila Maurício Santos , Wladimir Agostini Medrano , Suzy Tamie Niigaki , Vanessa Costhek Abílio Deficits in an operational measure of sensorimotor gating – the prepulse inhibition of startle (PPI) – are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). Some previous studies showed that the spontaneously hypertensive rats (SHR) present PPI deficit. Although SHR is...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 21, 2014 Category: Psychiatry Source Type: research

Anxiety comorbidity in bipolar spectrum disorders: The Mediational Role of Perfectionism in Prospective Depressive Symptoms
This study examined the role of maladaptive cognitive styles in the co-occurrence of BSDs and anxiety disorders and prediction of depressive symptoms. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - November 21, 2014 Category: Neurology Authors: Jared K. O'Garro-Moore, Ashleigh Molz Adams, Lyn Y. Abramson, Lauren B. Alloy Tags: Research report Source Type: research

Subcortical mapping of calculation processing in the right parietal lobe.
This report therefore supports direct electrical stimulation as a promising tool to improve the current knowledge on calculation processing connectivity. PMID: 25415072 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 21, 2014 Category: Neurosurgery Authors: Della Puppa A, De Pellegrin S, Lazzarini A, Gioffrè G, Rustemi O, Cagnin A, Scienza R, Semenza C Tags: J Neurosurg Source Type: research

Internet-Delivered Cognitive Behavior Therapy for Anxiety Disorders Is Here to Stay
Abstract Anxiety disorders are common and disabling. Cognitive behavior therapy is the treatment of choice but is often difficult to obtain. Automated, internet-delivered, cognitive behavior therapy (iCBT) courses may be an answer. There are three recent systematic reviews of randomized controlled trials that show that the benefits are substantial (d = 1.0) and similar to face to face CBT. There are two large effectiveness trials that demonstrate strong effects when iCBT is used in primary care; 60 % of patients who complete the courses no longer meet diagnostic criteria. The courses are suitable for most pe...
Source: Current Psychiatry Reports - November 20, 2014 Category: Psychiatry Source Type: research

Combined Ketamine/Transcranial Magnetic Stimulation Treatment of Severe Depression in Bipolar I Disorder
No abstract available (Source: The Journal of ECT)
Source: The Journal of ECT - November 20, 2014 Category: Psychiatry Tags: Letters to the Editor Source Type: research

Role of High-Frequency Repetitive Transcranial Magnetic Stimulation in Augmentation of Treatment of Bipolar Depression
No abstract available (Source: The Journal of ECT)
Source: The Journal of ECT - November 20, 2014 Category: Psychiatry Tags: Letters to the Editor Source Type: research

Predictors of Remission in 208 Drug-Resistant Depressive Patients Treated With Electroconvulsive Therapy
ConclusionMajor depressive disorder, short duration of the current episode, absence of psychotic symptoms, preserved insight, and adequate personal care are associated with complete remission in our sample of drug-resistant depressive patients treated with ECT. (Source: The Journal of ECT)
Source: The Journal of ECT - November 20, 2014 Category: Psychiatry Tags: Original Study Source Type: research

The Mood-Stabilizing Effects of Electroconvulsive Therapy
AbstractThe “ideal” mood stabilizer has been defined as an agent displaying demonstrated efficacy for the acute treatment and long-term prevention of both mania and depression. On the basis of a selective and an extensive review of the existing literature primarily focused on prospective and controlled studies, we discuss the potential mood-stabilizing effects of electroconvulsive therapy (ECT) and its efficacy for the acute treatment of bipolar depressive and mixed-manic states and the prevention of all types of recurrences of bipolar disorder (BD). We conclude that ECT should be considered an effective acute treatmen...
Source: The Journal of ECT - November 20, 2014 Category: Psychiatry Tags: Review Source Type: research

Amisulpride-associated mania in a young adult with schizophrenia and cerebral disease.
CONCLUSION: A 19-year-old man with schizophrenia and underlying cerebral disease developed rapid-onset mania after risperidone was replaced with amisulpride. The reaction resolved soon after amisulpride was discontinued and treatment with risperidone was reinstituted. PMID: 25404595 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2014 Category: Drugs & Pharmacology Authors: Chuang WC, Chen CY, Kuo SC, Chen TY, Yeh YW Tags: Am J Health Syst Pharm Source Type: research

Multielectrode Pulmonary Vein Ablation Catheter (PVAC ® )
Abstract Electrical isolation of pulmonary veins is the cornerstone of catheter ablation for patients with symptomatic atrial fibrillation. However, uncertainty surrounds the choice of energy source in pulmonary vein isolation (PVI). Various alternative techniques such as the Pulmonary Vein Ablation Catheter (PVAC®, Medtronic Inc., Minneapolis, MN, USA) have been developed to facilitate PVI. This over-the-wire multielectrode catheter is delivering duty-cycled bipolar and unipolar radiofrequency (RF) energy at relatively low power. PVI with this “one-shot” PVACatheter can shorten the procedure durat...
Source: Herzschrittmachertherapie und Elektrophysiologie - November 20, 2014 Category: Cardiology Source Type: research

Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?
Abstract Disturbances of glutamatergic neurotransmission and mononuclear phagocyte system activation have been described uni- and bipolar depression (UD/BD). Linking the glutamate and immune hypotheses of depression, quinolinic acid (QUIN) is synthesized by activated microglia and acts as an endogenous N-methyl-D-aspartate glutamate receptor (NMDA-R) agonist with neurotoxic properties. Recently, we observed an increased microglial QUIN expression in the subgenual and supracallosal, but not in the pregenual part of the anterior cingulate cortex in postmortem brains of suicide cases with severe depression. Since sev...
Source: European Archives of Psychiatry and Clinical Neuroscience - November 20, 2014 Category: Neuroscience Source Type: research

Reducing stigma toward people with bipolar disorder: Impact of a filmed theatrical intervention based on a personal narrative
Conclusion: This study demonstrated that a filmed dramatic intervention based on the lived experience of BD has statistically significant, sustainable stigma-reduction impacts for health-care service providers and more limited impacts for other target groups. This intervention can be considered an effective tool for use in stigma-reduction campaigns specifically targeting members of the health-care sector. Results are discussed in the context of multi-component stigma-reduction campaigns and the potential needs of target groups. (Source: International Journal of Social Psychiatry)
Source: International Journal of Social Psychiatry - November 20, 2014 Category: Psychiatry Authors: Hawke, L. D., Michalak, E. E., Maxwell, V., Parikh, S. V. Tags: Articles Source Type: research

Can You Get a Rash from Lamictal?
Lamictal - generic lamotrigine - prescribed for epilepsy and as a mood stabilizer for bipolar disorder - can cause serious, even life-threatening rashes. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 20, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Phase-corrected bipolar gradients in multi-echo gradient-echo sequences for quantitative susceptibility mapping
Conclusion With a linear phase correction between odd–even echoes, bipolar readout gradients can be used in multi-echo GRE sequences for QSM. (Source: Magnetic Resonance Materials in Physics, Biology and Medicine)
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - November 20, 2014 Category: Materials Science Source Type: research

A case of luteinized thecoma associated with sclerosing peritonitis treated with GnRH agonist and tamoxifen
We report a case of luteinized thecoma associated with sclerosing peritonitis in a 31-year-old woman with a history of bipolar disorder. The patient presented with abdominal distension, and imaging examinations revealed bilateral ovarian tumors with ascites and pleural effusion. A diagnostic laparotomy was performed and showed bilateral ovarian tumors with polypoid surface contours, yellow watery ascites, and diffusely indurated omentum. Left salpingo-oophorectomy followed by right salpingo-oophorectomy and omentectomy were performed. Twenty-one days after surgery, the patient developed an intestinal obstruction resistant ...
Source: International Cancer Conference Journal - November 20, 2014 Category: Cancer & Oncology Source Type: research

Bipolar versus monopolar transurethral resection of the prostate: A prospective randomized trial focussing on bleeding complications
To compare monopolar versus bipolar transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH) focussing on functional outcome, and rates of bleeding complications and TURP syndrome. (Source: The Journal of Urology)
Source: The Journal of Urology - November 20, 2014 Category: Urology & Nephrology Authors: P. Stucki, L. Marini, A. Mattei, K. Xafis, M. Boldini, H. Danuser Source Type: research

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans
by Lukas von Tobel, Tamara Mikeladze-Dvali, Marie Delattre, Fernando R. Balestra, Simon Blanchoud, Susanne Finger, Graham Knott, Thomas Müller-Reichert, Pierre Gönczy Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sperm cells, where such integrity is particularly critical. We identified C. elegans sas-1 in a genetic screen as a locus required for bipolar spindle assembly in the early embryo. Our analysis reveals that...
Source: PLoS Genetics - November 20, 2014 Category: Genetics & Stem Cells Authors: Lukas von Tobel et al. Source Type: research

De novo CNVs in bipolar affective disorder and schizophrenia
An increased rate of de novo copy number variants (CNVs) has been found in schizophrenia (SZ), autism and developmental delay. An increased rate has also been reported in bipolar affective disorder (BD). Here, in a larger BD sample, we aimed to replicate these findings and compare de novo CNVs between SZ and BD. We used Illumina microarrays to genotype 368 BD probands, 76 SZ probands and all their parents. Copy number variants were called by PennCNV and filtered for frequency (<1%) and size (>10 kb). Putative de novo CNVs were validated with the z-score algorithm, manual inspection of log R ratios (LRR) and qPCR prob...
Source: Human Molecular Genetics - November 20, 2014 Category: Genetics & Stem Cells Authors: Georgieva, L., Rees, E., Moran, J. L., Chambert, K. D., Milanova, V., Craddock, N., Purcell, S., Sklar, P., McCarroll, S., Holmans, P., O'Donovan, M. C., Owen, M. J., Kirov, G. Tags: ASSOCIATION STUDIES ARTICLES Source Type: research

Phase-corrected bipolar gradients in multi-echo gradient-echo sequences for quantitative susceptibility mapping.
CONCLUSION: With a linear phase correction between odd-even echoes, bipolar readout gradients can be used in multi-echo GRE sequences for QSM. PMID: 25408108 [PubMed - as supplied by publisher] (Source: Magma)
Source: Magma - November 20, 2014 Category: Radiology Authors: Li J, Chang S, Liu T, Jiang H, Dong F, Pei M, Wang Q, Wang Y Tags: MAGMA Source Type: research

Impact of cross-disorder polygenic risk on frontal brain activation with specific effect of schizophrenia risk
We examined this relationship in healthy individuals with (n=82) and without (n=57) a family history of bipolar disorder to determine whether this effect was additive or interactive dependent on the presence of family history. (Source: Schizophrenia Research)
Source: Schizophrenia Research - November 20, 2014 Category: Psychiatry Authors: Heather C. Whalley, Lynsey Hall, Liana Romaniuk, Alix Macdonald, Stephen M. Lawrie, Jessika E. Sussmann, Andrew M. McIntosh Source Type: research

Thyroid functioning in patients with bipolar disorder with mixed features
We compared the prevalence of thyroid dysfunction in patients with bipolar disorder with and without mixed features by measuring the levels of TSH, fT4, and T3. We reviewed the medical charts of patients between 2005 and 2013. No significant correlation was observed for any thyroid status between with and without mixed features. Taken together, these results did not show a significant difference in the association between thyroid dysfunction and the presence of mixed features. (Source: Psychiatry Research)
Source: Psychiatry Research - November 20, 2014 Category: Psychiatry Authors: In Hee Shim, Young Sup Woo, Dong Sik Bae, Won-Myong Bahk Tags: Brief report Source Type: research

Occipital bending (Yakovlevian torque) in bipolar depression
Differing levels of occipital lobe asymmetry and enlarged lateral ventricles have been reported within patients with bipolar disorder (BD) compared with healthy controls, suggesting different rates of occipital bending (OB). This may exert pressure on subcortical structures, such as the hippocampus, reduced among psychiatric patients. We investigated OB prevalence in 35 patients with BD and 36 healthy controls, and ventricular and occipital volumes. Prevalence was four times higher among BD patients (12/35 [34.3%]) than in control subjects (3/36 [8.3%]), as well as larger lateral ventricular volumes. (Source: Psychiatry Re...
Source: Psychiatry Research: Neuroimaging - November 20, 2014 Category: Psychiatry Authors: Jerome J. Maller, Rodney Anderson, Richard H. Thomson, Jeffrey V. Rosenfeld, Zafiris J. Daskalakis, Paul B. Fitzgerald Source Type: research

Degradation and biodegradability improvement of the olive mill wastewater by peroxi-electrocoagulation/electrooxidation-electroflotation process with bipolar aluminum electrodes.
In this study, the removal of pollutants (chemical oxygen demand (COD), biochemical oxygen demand (BOD5), polyphenols, turbidity, color, total suspended solids (TSS), and oil and grease) from olive oil mill processing wastewater by peroxi-electrocoagulation/electrooxidation-electroflotation process with bipolar aluminum electrodes was evaluated using a pilot continuous reactor. In the electrochemical unit, aluminum (Al), stainless steel, and RuO2/Ti plates were used. The effects of pH, hydrogen peroxide doses, current density, NaCl concentrations, and reaction times were studied. Under optimal conditions of pH 4, current d...
Source: Environmental Science and Pollution Research International - November 20, 2014 Category: Environmental Health Authors: Esfandyari Y, Mahdavi Y, Seyedsalehi M, Hoseini M, Safari GH, Ghozikali MG, Kamani H, Jaafari J Tags: Environ Sci Pollut Res Int Source Type: research

Validation of the Italian Version of the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN): Some Considerations on its Screening Usefulness.
CONCLUSION: The results show that the Italian version of BRIAN has good discriminant validity in detecting BD from healthy controls and shows good test-retest reliability. The study suggests the possibility of developing mixed screening tools by introducing items on dysregulation of biological rhythms to the usual measures of mood. PMID: 24987447 [PubMed] (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - November 19, 2014 Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research

Misdiagnosed hypomanic symptoms in patients with treatment-resistant major depressive disorder in Italy: results from the improve study.
CONCLUSIONS: This study suggests that screening for hypomania in MDD-resistant patients facilitates identification of a notable proportion of undiagnosed cases of bipolar spectrum disorder. Patients with a positive history of hypomania at screening had a demographic/clinical bipolar-like profile that included young age, higher number of previous depressive episodes and higher frequency of comorbid conditions. They also had both higher active and irritable hypomania symptom scores. PMID: 24761153 [PubMed] (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - November 19, 2014 Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research

The Use of Antidepressants in the Long-Term Treatment Should not Improve the Impact of Fibromyalgia on Quality of Life.
DISCUSSION: The results should be read in the light of the high prevalence of patients screened positive for Bipolar Disorders and of the well-known poor response of the mood symptoms to antidepressants in Bipolar Depression. The deterioration in the long-term management of FM patients following AD treatments suggests the need for new and robust studies. PMID: 23986787 [PubMed] (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - November 19, 2014 Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research

Social change and increasing of bipolar disorders: an evolutionary model.
CONCLUSIONS: If we postulate that mood disorders are on the increase and that the epidemic began in the 17th century with the "English malady", we must suppose that at least the "light" forms have an adaptive advantage, otherwise the expansion of the disorder would have been self-limiting. "Compulsive hyper-responsabilization", as well as explorative behaviours, may represent a base for adaptation in certain conditions of social change. The social emphasis in individualism and responsibility may have changed not only the frequency, but also the phenomenology of mood disorders particularly the increases in bipolar disorders...
Source: Clinical Practice and Epidemiology in Mental Health - November 19, 2014 Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research

Could hypomanic traits explain selective migration? Verifying the hypothesis by the surveys on sardinian migrants.
DISCUSSION: Data point to a bipolar disorder risk for young (probably hypomanic) male migrants in competitive, challenging conditions; and a different kind of depressive episodes for women in trying economic conditions. The results of the survey on Sardinian migrants are partially in agreement with the hypothesis of a selective migration of people with a hypomanic temperament. Early motivations and self-esteem seem related to the ways mood disorders are expressed, and to the vulnerability to specific triggering situations in the host country. PMID: 23248679 [PubMed] (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - November 19, 2014 Category: Psychiatry Tags: Clin Pract Epidemiol Ment Health Source Type: research