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Lithium prevents aberrant NMDA-induced F-actin reorganization in neurons
Increasing evidence suggests that cellular stress may underlie mood disorders such as bipolar disorder and major depression, particularly as lithium and its targets can protect against neuronal cell death. Here we describe N-methyl-D-aspartate (NMDA)-induced filamentous actin reorganization (NIFAR) as a useful in-vitro model for studying acute neurocellular stress and investigating the effects of mood stabilizers. Brief incubation of cultured neurons with NMDA (50 µM, 5 min) induces marked reorganization of F-actin within the somatodendritic domain of a majority of neurons. During NIFAR, F-actin is rapidly depleted fr...
Source: NeuroReport - October 31, 2014 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Clinical and psychological repercussions of videolaparoscopic tubal ligation: observational, single cohort, retrospective study.
CONCLUSION: Regardless of the technique used, videolaparoscopic tubal ligation had repercussions consisting of increased menstrual flow and premenstrual symptoms, especially in women aged ≤ 35 years, and also had a negative influence on sexual activity. PMID: 25351752 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - October 31, 2014 Category: Journals (General) Authors: Dias DS, Dias R, Nahás-Neto J, Nahás EA, Leite NJ, Bueloni-Dias FN, Modotti WP Tags: Sao Paulo Med J Source Type: research

A cross‐sectional study of thyroid function in 66 patients with bipolar disorder receiving lithium for 10–44 years
ConclusionsThese results confirm the greater susceptibility of female subjects for disturbances of thyroid hormones during lithium therapy, with one‐fifth of them showing some features of hypothyroidism. Abnormally high levels of anti‐TPO and anti‐TG antibodies were shown in a significant proportion of patients. However, in contrast to the effect of lithium on kidney function, our results do not show an association between the duration of lithium therapy and thyroid dysfunction. (Source: Bipolar Disorders)
Source: Bipolar Disorders - October 31, 2014 Category: Psychiatry Authors: Agnieszka Kraszewska, Maria Chlopocka‐Wozniak, Maria Abramowicz, Jerzy Sowinski, Janusz K Rybakowski Tags: Original Article Source Type: research

Meta‐analysis of the association between suicidal ideation and later suicide among patients with either a schizophrenia spectrum psychosis or a mood disorder
ConclusionAlthough our findings suggest that the association between suicidal ideation and later suicide is stronger in schizophrenia spectrum psychosis than in mood disorders this result should be interpreted cautiously due to the high degree of between‐study heterogeneity and because studies that used stronger methods of reporting had a weaker association between suicidal ideation and suicide. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - October 31, 2014 Category: Psychiatry Authors: C. L. Chapman, K. Mullin, C. J. Ryan, A. Kuffel, O. Nielssen, M. M. Large Tags: Meta‐analysis Source Type: research

Suicidal behaviour in bipolar disorder: understanding the role of affective states - Saunders KE, Hawton K.
[Abstract unavailable] Language: en... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 31, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

The circadian system of patients with bipolar disorder differs in episodes of mania and depression
ConclusionsThe data revealed differences in the functional state of the circadian system in patients with bipolar disorder depending on whether they were experiencing a manic or a depressive episode. (Source: Bipolar Disorders)
Source: Bipolar Disorders - October 31, 2014 Category: Psychiatry Authors: Marta Nováková, Ján Praško, Klára Látalová, Martin Sládek, Alena Sumová Tags: Original Article Source Type: research

Neurofunctional effects of quetiapine in patients with bipolar mania
ConclusionsThese findings are consistent with suggestions that mania involves a loss of emotional modulatory activity in the prefrontal cortex—restoration of the relatively greater elevation in prefrontal activity widely observed in euthymic patients is associated with clinical improvement. It is not clear, however, whether changes are related to quetiapine treatment or represent a non‐specific marker of affective change. (Source: Bipolar Disorders)
Source: Bipolar Disorders - October 31, 2014 Category: Psychiatry Authors: Andrew K Davis, Melissa P DelBello, James Eliassen, Jeffrey Welge, Thomas J Blom, David E Fleck, Wade A Weber, Kelly B Jarvis, Emily Rummelhoff, Stephen M Strakowski, Caleb M Adler Tags: Brief Report Source Type: research

Don't Challenge My Bipolar Diagnosis!
One of the worst things you can do to someone with bipolar disorder is refuse to admit the diagnosis, or refuse to take it seriously. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 31, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Don't tell me how to get over bipolar disorder!
Your words can do a lot of damage to a loved one with bipolar disorder, and those who don't know enough about this illness can actually be cruel. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 31, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Factors That Increase the Risk of Violent...
Doctors have identified factors that increase the chance a person with bipolar will be violent, including a history of emotional abuse and other childhood traumas. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 31, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

12 Things You Need to Know About Zoloft...
Important information about the antidepressant sertraline - brand name Zoloft - including side effects, overdose symptoms, drug interactions and more. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 31, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Early parent–child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16‐year prospective cohort study
ConclusionsNeglect from mother is a significant early predictor of mood disorder in offspring at familial risk for BD and may increase emotional sensitivity. Psychosocial support and interventions for high‐risk families could be beneficial in reducing early adversity, maternal neglect and the risk of subsequent mood disorders in offspring. (Source: Early Intervention in Psychiatry)
Source: Early Intervention in Psychiatry - October 30, 2014 Category: Psychiatry Authors: Sarah Doucette, Adrian Levy, Gordon Flowerdew, Julie Horrocks, Paul Grof, Mark Ellenbogen, Anne Duffy Tags: Original Article Source Type: research

A bold meta-analysis on suicidality in bipolar disorder - Baethge C.
The International Society for Bipolar Disorders Task Force on Suicide presents the results of a bold undertaking. The task force members, 20 eminent researchers in the field, carried out a systemic review and meta-analysis on factors associated with sui... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 30, 2014 Category: Global & Universal Tags: Research Methods, Surveillance and Codes, Models Source Type: news

4 People - 4 Types of Depression
Feeling worthless and/or feeling unreasonably or excessively guilty is frequently found in people having a depressive episode of bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 30, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar staining of gram-negative bacillus in cerebrospinal fluid
(Source: Blood)
Source: Blood - October 30, 2014 Category: Hematology Authors: Racsa, L. D., Burd, E. M. Tags: Free Research Articles, BloodWork, Clinical Trials and Observations BLOOD WORK Source Type: research

Recovery From 'Schizophrenia': One Man's Journey From Patient to Therapist
"Schizophrenia" is a name, not a disease. It presents in many different ways and has many different outcomes. There is certainly not one cause of "schizophrenia"; there may be hundreds of contributing factors working through bewilderingly complex interactions. Figuring all this out will likely be the painstaking work of many decades. Eventually, what we now call "schizophrenia" will turn out to be hundreds of much better-defined conditions. There are many effective treatments for "schizophrenia," but no one size fits all. Most people need medication, at least during the acute phases. Psychotherapy, social-skills and vocat...
Source: Science - The Huffington Post - October 29, 2014 Category: Science Source Type: news

New technology shows promise for delivery of therapeutics to the brain
(Virginia Tech) The researchers from the Virginia Tech -- Wake Forest University School of Biomedical Engineering and Sciences described in their article in Technology published by the World Scientific Publishing Company that they have created 'a tool for blood-barrier-brain disruption that uses bursts of sub-microsecond bipolar pulses to enhance the transfer of large molecules to the brain.' (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2014 Category: Cancer & Oncology Source Type: news

Antitachycardia Pacing Therapy for the Successful Treatment of Lead Fracture
This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - October 29, 2014 Category: Cardiology Authors: Ashish A. Bhimani, Peerawut Deeprasertkul, Nischala Nannapaneni, George N. Carayannopoulos Tags: EP Image Source Type: research

Diagnostic stability in pediatric bipolar disorder
The diagnostic stability of pediatric bipolar disorder has not been investigated previously. The aim was to investigate the diagnostic stability of the ICD-10 diagnosis of pediatric mania/bipolar disorder. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 29, 2014 Category: Neurology Authors: Lars Vedel Kessing, Eleni Vradi, Per Kragh Andersen Tags: Research report Source Type: research

Clinical efficacy of bipolar radiofrequency ablation of small renal masses
Conclusions Multipolar RFA is clinically successful for treating SRMs. Using preoperatively calculated energy settings, tailored size tumor lesions could be created. Clinical efficacy and oncological outcomes need to be investigated further in studies using multipolar RFA in a percutaneous fashion. (Source: World Journal of Urology)
Source: World Journal of Urology - October 29, 2014 Category: Urology & Nephrology Source Type: research

Bipolar disorder.
Authors: Abstract Essential facts Bipolar disorder is a potentially lifelong and disabling condition. Bipolar I, characterised by episodes of mania and depression, is estimated to affect 1 per cent of the adult population. Bipolar II, characterised by hypomania and depression, affects an estimated 0.4 per cent of adults. Episodes can vary in length and frequency. PMID: 25351068 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - October 29, 2014 Category: Nursing Tags: Nurs Stand Source Type: research

The Secret World of Schizophrenia
The treatment for schizophrenia and manic-depression have shockingly deteriorated throughout my professional lifetime, dating back to 1971. During the hopeful period of deinstitutionalization, it seemed like we were turning the corner. Finally, an enlightened age, finally. It didn’t happen. read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - October 28, 2014 Category: Psychiatry & Psychology Authors: Robert Berezin, M.D. Tags: Cognition Depression Neuroscience Personality Psychiatry Source Type: news

Is it possible to combine different psychotic symptom scales in bipolar disorder?
It has been suggested that data on positive and negative psychotic symptoms in patients with schizophrenia as assessed using different scales may be combined. For the first time, we assessed correlations between the positive syndrome subscale of the Positive and Negative Syndrome Scale (PANSS-P) and the Scale for the Assessment of Positive Symptoms (SAPS), and between the negative syndrome subscale of the Positive and Negative Syndrome Scale (PANSS-N) and the Scale for the Assessment of Negative Symptoms (SANS) in patients with bipolar disorder. (Source: Psychiatry Research)
Source: Psychiatry Research - October 28, 2014 Category: Psychiatry Authors: Helena Fernandez-Garcimartin, Alexandra Bagney, Marta Moreno-Ortega, Monica Dompablo, Iosune Torio, Antonio Lobo, Miguel-Angel Jimenez-Arriero, Tomas Palomo, Roberto Rodriguez-Jimenez Source Type: research

Table of Contents
Abstract Use of easily available biomarker could predict antidepressant response Antipsychotics show differing risks of mortality in community‐living elderly Oxcarbazepine‐induced serious skin reaction Long‐acting injectable aripiprazole comparable to oral medication in preventing relapse Adjunctive armodafinil shows promising results for bipolar depression Omega‐3 fatty acids fail to prevent relapse in schizophrenia Lower‐dose quetiapine safe and effective for personality disorder Varenicline aids smoking cessation in patients with bipolar disorder Older adults see heart benefits from antidepressant adherence Ap...
Source: The Brown University Psychopharmacology Update - October 27, 2014 Category: Psychiatry Source Type: research

Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder
Conclusions Lithium and rs334558 influenced GM volumes in areas critical for the generation and control of affect, which have been widely implicated in the process of BD pathophysiology. In the light of the protective effects of lithium on white matter integrity, our results suggest that the clinical effects of lithium associate with a neurotrophic effect on the whole brain, probably mediated by GSK-3β inhibition. (Source: Psychopharmacology)
Source: Psychopharmacology - October 27, 2014 Category: Psychiatry Source Type: research

Clozapine for treatment‐resistant bipolar disorder: a systematic review
ConclusionThe limited current evidence supports the concept that clozapine may be both an effective and a relatively safe medication for TRBD. (Source: Bipolar Disorders)
Source: Bipolar Disorders - October 27, 2014 Category: Psychiatry Authors: Xian‐Bin Li, Yi‐Lang Tang, Chuan‐Yue Wang, Jose Leon Tags: Review Article Source Type: research

Whole genome/exome sequencing in mood and psychotic disorders - Kato T.
Recent developments in DNA sequencing technologies have allowed for genetic studies using whole genome or exome analysis, and these have been applied in the study of mood and psychotic disorders, including bipolar disorder, depression, schizophrenia, and s... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 27, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

The Story Behind Rapper DMX and Bipolar Disorder
DMX, born Earl Simmons, one of hip-hop's most beloved and influential heroes, admitted to having bipolar disorder, then denied it, then confirmed it. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 27, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Psychiatric factors do not affect recurrence risk of hyperemesis gravidarum
ConclusionThis study is the first to analyze the relationship of psychiatric factors to risk of recurrence of HG. No factors were identified that increase the risk of recurrence including stress symptoms following a HG pregnancy. Psychological sequelae associated with HG are probably a result of the physical symptoms of prolonged severe nausea and vomiting, medication and/or hospitalization, and likely play no role in disease etiology. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - October 27, 2014 Category: OBGYN Authors: Aromalyn Magtira, Frederic Paik Schoenberg, Kimber MacGibbon, Khalil Tabsh, Marlena S. Fejzo Tags: Original Article Source Type: research

Operational challenges of retinal prostheses
Two computational models for research on retinal implants are presented. In the first model, the electric field produced by a multi-electrode array in a uniform retina is calculated. It is shown how cross talk of activated electrodes and the resulting bunching of field lines in monopole and dipole activation prevent high resolution imaging with retinal implants. Furthermore, it is demonstrated how sequential stimulation and multipolar stimulation may overcome this limitation. In the second model a target volume, i.e., a probe cylinder approximating a bipolar cell, in the retina is chosen, and the passive Heaviside cable eq...
Source: Medical Engineering and Physics - October 27, 2014 Category: Biomedical Engineering Authors: Erich W. Schmid, Wolfgang Fink, Robert Wilke Source Type: research

Inositol synthesis regulates activation of GSK‐3α in neuronal cells
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - October 26, 2014 Category: Neurology Authors: Cunqi Ye, Miriam L. Greenberg Tags: Original Article Source Type: research

The expanding fireball of Nova Delphini 2013
Nature advance online publication 26 October 2014. doi:10.1038/nature13834 Authors: G. H. Schaefer, T. ten Brummelaar, D. R. Gies, C. D. Farrington, B. Kloppenborg, O. Chesneau, J. D. Monnier, S. T. Ridgway, N. Scott, I. Tallon-Bosc, H. A. McAlister, T. Boyajian, V. Maestro, D. Mourard, A. Meilland, N. Nardetto, P. Stee, J. Sturmann, N. Vargas, F. Baron, M. Ireland, E. K. Baines, X. Che, J. Jones, N. D. Richardson, R. M. Roettenbacher, L. Sturmann, N. H. Turner, P. Tuthill, G. van Belle, K. von Braun, R. T. Zavala, D. P. K. Banerjee, N. M. Ashok, V. Joshi, J. Becker & P. S. Muirhead A classical nova occurs when materi...
Source: Nature AOP - October 26, 2014 Category: Research Authors: G. H. SchaeferT. ten BrummelaarD. R. GiesC. D. FarringtonB. KloppenborgO. ChesneauJ. D. MonnierS. T. RidgwayN. ScottI. Tallon-BoscH. A. McAlisterT. BoyajianV. MaestroD. MourardA. MeillandN. NardettoP. SteeJ. SturmannN. VargasF. BaronM. IrelandE. K. Baines Tags: Letter Source Type: research

Carboxyhaemoglobin formation and ECG changes during hysteroscopic surgery, transurethral prostatectomy and tonsillectomy using bipolar diathermy
Summary Diathermy is known to produce a mixture of waste products including carbon monoxide. During transcervical hysteroscopic surgery, carbon monoxide might enter the circulation leading to the formation of carboxyhaemoglobin. In 20 patients scheduled for transcervical hysteroscopic resection of myoma or endometrium, carboxyhaemoglobin was measured before and at the end of the surgical procedure, and compared with levels measured in 20 patients during transurethral prostatectomy, and in 20 patients during tonsillectomy. Haemodynamic data, including ST‐segment changes, were recorded. Levels of carboxyhaemoglobin increas...
Source: Anaesthesia - October 25, 2014 Category: Anesthesiology Authors: L. E. Overdijk, P. J. M. Kesteren, P. Haan, N. C. J. Schellekens, L. M. Dijksman, M. C. Hovius, R. G. Berg, E. A. Bakkum, B. M. P. Rademaker Tags: Original Article Source Type: research

The role of the bipolar plasmakinetic TURP over 100 g prostate in the elderly patients
Conclusions BP-TURP is a safe and highly effective treatment modality for BPE in the elderly patients with prostate glands over 100 g. Clinical efficacy and postoperative 12th month’s results were similar to SP. Larger studies with longer follow-up are needed in order to confirm our findings. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 25, 2014 Category: Urology & Nephrology Source Type: research

Pregnancy in women with an implantable cardioverter-defibrillator: is it safe?
Conclusions Pregnancy had no effect on ICD operation and no evidence was found to link ICD carriage with adverse pregnancy outcomes, although one miscarriage may have been induced by ICD shock therapy. A worsening of cardiac condition occurs in specific cardiac diseases and β-blocker therapy should be continued for all women carrying ICDs in pregnancy as the benefits outweigh the risks of taking this medication. (Source: Europace)
Source: Europace - October 25, 2014 Category: Cardiology Authors: Boule, S., Ovart, L., Marquie, C., Botcherby, E., Klug, D., Kouakam, C., Brigadeau, F., Guedon-Moreau, L., Wissocque, L., Meurice, J., Lacroix, D., Kacet, S. Tags: Sudden death and ICDs Source Type: research

Bipolar ablation for deep intra-myocardial circuits: human ex vivo development and in vivo experience
Conclusion By using a bipolar ablation technique, we have demonstrated the creation of significantly deeper lesions without increasing the lesion width, compared with standard ablation. Further clinical trials are warranted to detail the risks of this technique. (Source: Europace)
Source: Europace - October 25, 2014 Category: Cardiology Authors: Gizurarson, S., Spears, D., Sivagangabalan, G., Farid, T., Ha, A. C. T., Masse, S., Kusha, M., Chauhan, V. S., Nair, K., Harris, L., Downar, E., Nanthakumar, K. Tags: BASIC SCIENCE Source Type: research

4 People - 4 Types of Depression
Being unable to concentrate or to make a decision easily may contribute to a diagnosis of depression or bipolar depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What Is Hyponatremia?
Hyponatremia is a low concentration of sodium in the blood. It can occur as a side effect of some medications that are used to treat bipolar disorder. More... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Monsters, Demons, and the Antichrist - 5...
These true stories of delusions experienced by people with bipolar disorder show just how frightening psychotic symptoms can be. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Hate Mail: "This bipolar nonsense"
It must be an American thing, this bipolar nonsense - or so says this writer, who also says that MAYBE there are legitimate bipolar patients. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Learn the Behaviors and Warning Signs of...
Behaviors and symptoms that are warning signs of bipolar disorder in adults and children. Also: information on diagnosing bipolar disorder and treatment options for people with bipolar. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Is Metformin Helpful for Weight Loss When...
It's well known that atypical antipsychotics (AAPs) such as Zyprexa and Seroquel cause weight gain. Can the diabetes drug metformin help? (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Incidence of urethral stricture after bipolar transurethral resection of the prostate using TURis: results from a randomised trial
ConclusionThe TURis system seems to be as efficacious and safe as conventional M‐TURP except that there was a higher incidence of urethral stricture in patients with larger preoperative prostate volumes. (Source: BJU International)
Source: BJU International - October 24, 2014 Category: Urology & Nephrology Authors: Kazumasa Komura, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Koichiro Minami, Rintaro Oide, Hirofumi Uehara, Kiyoshi Takahara, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Toshikazu Watsuji, Haruhito Azuma Tags: Functional Urology Source Type: research

A novel cognitive behaviour therapy for bipolar disorders (Think Effectively About Mood Swings or TEAMS): study protocol for a randomized controlled trial
DiscussionThe design will provide preliminary evidence of efficacy, feasibility, acceptability, uptake, attrition and barriers to treatment to design a definitive trial of this novel intervention compared to treatment as usual.Trial registration: This trial was registered with Current Controlled Trials (ISRCTN83928726) on registered 25 July 2014. (Source: Trials)
Source: Trials - October 24, 2014 Category: Journals (General) Authors: Warren MansellSara TaiAlexandra ClarkSavas AkgonulGraham DunnLinda DaviesHeather LawRichard MorrissNeil TinningAnthony Morrison Source Type: research

Table of Contents
Abstract Maternal depression, environmental factors linked to different trajectories of childhood irritability Family and cognitive therapy delivered via 12 manualized sessions effective for bipolar disorder Foster care intervention leads to reduction in psychotic symptoms College students’ daily use of marijuana at 30‐year high Lamotrigine found safe and effective in adolescent depression in retrospective chart review Inconclusive results for duloxetine treatment for MDD in children and adolescents Rescheduling prescription hydrocodone combination drug products (Source: The Brown University Child and Adolescent Psychopharmacology Update)
Source: The Brown University Child and Adolescent Psychopharmacology Update - October 23, 2014 Category: Psychiatry Source Type: research

Multipolar radiofrequency ablation with non-touch technique for hepatocellular carcinoma ≤ 3 cm: A preliminary report
Conclusion Multipolar RFA with non-touch technique is an effective method to achieve complete tumor ablation and an adequate safety margin. This method has low complication rate and bears minimal risk of tumor seeding. (Source: Advances in Digestive Medicine)
Source: Advances in Digestive Medicine - October 23, 2014 Category: Gastroenterology Source Type: research

Topoisomerase II Is Required for the Proper Separation of Heterochromatic Regions during Drosophila melanogaster Female Meiosis
by Stacie E. Hughes, R. Scott Hawley Heterochromatic homology ensures the segregation of achiasmate chromosomes during meiosis I in Drosophila melanogaster females, perhaps as a consequence of the heterochromatic threads that connect achiasmate homologs during prometaphase I. Here, we ask how these threads, and other possible heterochromatic entanglements, are resolved prior to anaphase I. We show that the knockdown of Topoisomerase II (Top2) by RNAi in the later stages of meiosis results in a specific defect in the separation of heterochromatic regions after spindle assembly. In Top2 RNAi-expressing oocytes, heterochroma...
Source: PLoS Genetics - October 23, 2014 Category: Genetics & Stem Cells Authors: Stacie E. Hughes et al. Source Type: research

Licensing of Yeast Centrosome Duplication Requires Phosphoregulation of Sfi1
by Jennifer S. Avena, Shannon Burns, Zulin Yu, Christopher C. Ebmeier, William M. Old, Sue L. Jaspersen, Mark Winey Duplication of centrosomes once per cell cycle is essential for bipolar spindle formation and genome maintenance and is controlled in part by cyclin-dependent kinases (Cdks). Our study identifies Sfi1, a conserved component of centrosomes, as the first Cdk substrate required to restrict centrosome duplication to once per cell cycle. We found that reducing Cdk1 phosphorylation by changing Sfi1 phosphorylation sites to nonphosphorylatable residues leads to defects in separation of duplicated spindle pole bodie...
Source: PLoS Genetics - October 23, 2014 Category: Genetics & Stem Cells Authors: Jennifer S. Avena et al. Source Type: research

Repeated positive fighting experience in male inbred mice
Nature Protocols 9, 2705 (2014). doi:10.1038/nprot.2014.156 Authors: Natalia N Kudryavtseva, Dmitry A Smagin, Irina L Kovalenko & Galina B Vishnivetskaya Repeated aggression is a frequent symptom of many psychiatric and neurological disorders, including obsessive-compulsive and attention deficit hyperactivity disorders, bipolar and post-traumatic stress disorders, epilepsy, autism, schizophrenia and drug abuse. However, repeated aggression is insufficiently studied because there is a lack of adequate models in (Source: Nature Protocols)
Source: Nature Protocols - October 23, 2014 Category: Biomedical Science Authors: Natalia N KudryavtsevaDmitry A SmaginIrina L KovalenkoGalina B Vishnivetskaya Tags: Protocol Source Type: research

Yes, "Walking Corpse Syndrome" Is a Real Thing
class="no-js" itemscope itemtype="http://schema.org/Article" > itemprop="description" >I was startled (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news