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New antidepressant: Rapid agent restores pleasure-seeking ahead of other antidepressant action
A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of -- and ahead of -- its other antidepressant effects. Within 40 minutes after a single infusion of ketamine, treatment-resistant depressed bipolar disorder patients experienced a reversal of a key symptom -- loss of interest in pleasurable activities -- which lasted up to 14 days. Brain scans traced the agent's action to boosted activity in areas at the front and deep in the right hemisphere of the brain. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 20, 2014 Category: Science Source Type: news

Aspirin shown to benefit schizophrenia treatment
Some anti-inflammatory medicines, such as aspirin, estrogen, and Fluimucil, can improve the efficacy of existing schizophrenia treatments, new research suggests. Research has shown that the immune system is linked to certain psychiatric disorders, such as schizophrenia and bipolar disorder. Research has shown that "antioxidants and anti-inflammatory drugs could not only reduce symptoms associated with the disorders but also prevent the appearance of neurobiological abnormalities and transition to psychosis if given early during brain development," experts say. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 20, 2014 Category: Science Source Type: news

Rapid agent restores pleasure-seeking ahead of other antidepressant action
(NIH/National Institute of Mental Health) A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of -- and ahead of -- its other antidepressant effectsWithin 40 minutes after a single infusion of ketamine, treatment-resistant depressed bipolar disorder patients experienced a reversal of a key symptom -- loss of interest in pleasurable activities -- which lasted up to 14 days. Brain scans traced the agent's action to boosted activity in areas at the front and deep in the right hemisphere of the brain. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 20, 2014 Category: Global & Universal Source Type: news

Postsurgical Hypoparathyroidism—Risk of Fractures, Psychiatric Diseases, Cancer, Cataract, and Infections
In conclusion, HypoPT is associated with an increased risk of depression and other types of neuropsychiatric diseases as well as infections, whereas patients seem to be protected against fractures at the upper extremities and gastrointestinal malignancies. © 2014 American Society for Bone and Mineral Research. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - October 20, 2014 Category: Orthopaedics Authors: Line Underbjerg, Tanja Sikjaer, Leif Mosekilde, Lars Rejnmark Tags: Original Article Source Type: research

Minimally Invasive Vaginal Hysterectomy: A Single Surgeons’ Experience of the ERBE BiClamp Bipolar Vessel Sealing System
Does the use of the ERBE BiClamp© bipolar vessel sealing system (BVSS) in vaginal hysterectomy compromise surgical outcome? (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: G.V. Blayney, J.P. Beirne, L. Hinds, G.J. Dorman, D. Quinn Source Type: research

Assessment of Pressure Control Characteristics of the MyoSure, TruClear, and Symphion Bipolar Hysteroscopic Tissue Removal Systems. A Three-Arm, Bench Study
To compare the intrauterine pressure control characteristics of the MyoSure tissue removal device with the Aquilex fluid management controller, the TruClear morcellator with the Smith & Nephew Hysteroscopic Fluid Management controller, and the integrated Symphion bipolar hysteroscopic tissue removal system. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: A.I. Brill, A. Garcia Source Type: research

Removal of Endometrial Polyps: Hysteroscopic Morcellation vs. Bipolar Resectoscopy, a Randomized Trial
To compare hysteroscopic morcellation (HM) with bipolar resectoscopy for removal of endometrial polyps in terms of procedure time, peri- and post-operative adverse events, tissue availability, and short-term effectiveness. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: T.W.O. Hamerlynck, B.C. Schoot, H.A.A.M. Van Vliet, S. Weyers Source Type: research

Endometrioma Excision Utilizing Plasma Energy
Optimal endometrioma treatment in reproductive age women weighs inadvertent follicle destruction against endometrioma recurrence. Current endometrioma surgical management is largely influenced by a Cochrane review that reported endometriomas greater than 3cm have a higher recurrence rate when ablated with bipolar energy versus cyst excision. Recent investigation by Roman et al, however, suggests that cyst fenestration and plasma vaporization may preserve antral follicles without compromising cyst recurrence or subsequent pregnancy rates. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: M.J.S. Uy-Kroh, T. Falcone Source Type: research

New-Generation Reusable Bipolar Electrode in Office Hysteroscopy
To determine the feasibility of using a new-generation reusable bipolar electrode to perform surgery of focal uterine lesions in office hysteroscopy and secondly the possibility of cost reduction in office hysteroscopy. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: G. Cammareri, C. Lanzani, F. Cirillo, F.G. Turba, S. Rehman, E. Ferrazzi Source Type: research

“Cold Loop Technique” and Bipolar Technology: A Safer Hysteroscopic Approach to Remove Submucosal Myomas with Intramural Development in a Single Surgical Step
To evaluate safety and efficacy of the cold loop technique applied to bipolar resectoscope for the removal of submucosal myomas with intramural development. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: A. Di Spiezio Sardo, G. Calagna, M. Spinelli, C. Coppola, B. Zizolfi, A. Perino, C. Nappi Source Type: research

Preliminary Results of a Randomized Controlled Trial of the Cardea™ GEA System Versus Transcervical Resection of the Endometrium (TCRE) Combined with Roller-Ball Ablation for the Treatment of Abnormal Uterine Bleeding
To evaluate the safety and effectiveness of the CardeaTM GEA System (a bipolar RF ablation system with 5.5 mm probe diameter) as compared to the control (TCRE - Trans Cervical Resection of the Endometrium combined with roller-ball ablation) for the treatment of abnormal uterine bleeding. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: L. Feng, Z. Zhang, Q. Yang, Q. Chen Source Type: research

A Pilot Study to Assess the Feasibility of the Symphion Bipolar Hysteroscopic Tissue Resection System in an Office Environment
To assess the feasibility of the Symphion bipolar hysteroscopic tissue resection system for advanced hysteroscopic surgical procedures such as polypectomy and myomectomy performed in the office. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: A.L. Garcia, A.I. Brill, E. Skalnyi Source Type: research

Short Term Complication Rate of Operative Hysteroscopy Using Only Bipolar Technology: Analysis of 709 Cases
To evaluate short term complication rate of operative hysteroscopy using only bipolar energy with normal saline solution. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: J. Sroussi, A. Hamidouche, M. Mezzadri, A.S. Chevalier, M. Piketty, J.L. Benifla Source Type: research

TLH Made More Safe by Tackling Uterine Artery at Origin
Laparoscopic Hysterectomy techniques keeps changing, specially with different methods of tackling uterine arteries. A comparative evaluation of skeletonization of uterines followed by Bipolar or suturing, vessel sealing devices & tackling uterine artery at the origin from internal iliac artery. We evaluated bleeding, possiblity in difficult pathology & specially ureteric or vesical injury. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: P.H. Trivedi Source Type: research

Uterine Septum Resection
A 20 year old G0 presented with right lower quadrant pain and was found to have broad based uterine septum potentially inhibiting menstrual efflux from the right side of the uterus. Ultrasound images are shown to aid in the diagnosis. We demonstrate safe excision of a large uterine septum using simultaneous hysteroscopy and laparoscopy. Hemostatic dissection is demonstrated using the a bipolar twizzle electrode and hysteroscopic scissors. We highlight the use of simultaneous laparoscopy to confirm the diagnosis prior to resection, monitor the depth of dissection in order to avoid uterine perforation, and to evaluate and tr...
Source: The Journal of Minimally Invasive Gynecology - October 19, 2014 Category: OBGYN Authors: J.M.B. Ritch, A.C. Yunker, T.L. Anderson Source Type: research

Insulin resistance and outcome in bipolar disorder.
Conclusions Comorbid insulin resistance may be an important factor in resistance to treatment in bipolar disorder. PMID: 25323142 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - October 19, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

4 People - 4 Types of Depression
When take with other symptoms, insomnia - having trouble getting to sleep or staying asleep - and hypersomnia - sleeping too much - can be a sign of depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 19, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

YouTube as peer support for severe mental illness
People with severe mental illness such as schizophrenia, schizoaffective disorder or bipolar disorder use a popular social media website like YouTube to provide and receive naturally occurring peer support, researchers report. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 17, 2014 Category: Science Source Type: news

Immunohistochemical mapping of neuropeptide Y in the tree shrew brain
ABSTRACT Day‐active tree shrews are promising animals as research models for a variety of human disorders. Neuropeptide Y (NPY) modulates many behaviors in vertebrates. Here, we examined the distribution of NPY in the brain of tree shrews (Tupaia belangeri chinensis) using immunohistochemical techniques. The differential distribution of NPY‐immunoreactive (‐ir) cells and fibers were observed in the rhinencephalon, telencephalon, diencephalon, mesencephalon, metencephalon and myelencephalon of tree shrews. Most NPY‐ir cells were multipolar or bipolar in shape with triangular, fusiform and/or globular perikarya. The ...
Source: The Journal of Comparative Neurology - October 17, 2014 Category: Neurology Authors: Rong‐Jun Ni, Yu‐Mian Shu, Peng‐Hao Luo, Hui Fang, Yu Wang, Lei Yao, Jiang‐Ning Zhou Tags: Research Article Source Type: research

YouTube as Peer Support for Severe Mental Illness
People with severe mental illness such as schizophrenia, schizoaffective disorder or bipolar disorder use a popular social media website like YouTube to provide and receive naturally occurring peer support, Dartmouth researchers report in the journal PLOS ONE. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - October 17, 2014 Category: Hospital Management Authors: Annmarie Christensen Tags: Features News John Naslund mental illness research social media The Dartmouth Institute Source Type: news

YouTube as peer support for severe mental illness
(The Geisel School of Medicine at Dartmouth) People with severe mental illness such as schizophrenia, schizoaffective disorder or bipolar disorder use a popular social media website like YouTube to provide and receive naturally occurring peer support, Dartmouth researchers report in the journal PLOS ONE. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 17, 2014 Category: Global & Universal Source Type: news

The diagnosis and treatment of bipolar disorder: decision-making in primary care.
This article describes key decision-making steps in the management of bipolar disorder from the primary care perspective: from initial clinical suspicion to confirmation of the diagnosis to decision-making in acute and longer-term management and the importance of patient monitoring. PMID: 25317368 [PubMed] (Source: Primary Care)
Source: Primary Care - October 17, 2014 Category: Primary Care Authors: Culpepper L Tags: Prim Care Companion CNS Disord Source Type: research

Demographics, clinical characteristics, and treatment of aggressive patients admitted to the acute behavioral unit of a community general hospital: a prospective observational study.
CONCLUSION: Patients significantly improved over time in both severity of illness and level of aggression. PMID: 25317364 [PubMed] (Source: Primary Care)
Source: Primary Care - October 17, 2014 Category: Primary Care Authors: Nourse R, Reade C, Stoltzfus J, Mittal V Tags: Prim Care Companion CNS Disord Source Type: research

[Report] Laboratory formation of a scaled protostellar jet by coaligned poloidal magnetic field
A scaled-down plasma experiment shows that axial magnetic fields in young stars can shape their bipolar jet outflows. Authors: B. Albertazzi, A. Ciardi, M. Nakatsutsumi, T. Vinci, J. Béard, R. Bonito, J. Billette, M. Borghesi, Z. Burkley, S. N. Chen, T. E. Cowan, T. Herrmannsdörfer, D. P. Higginson, F. Kroll, S. A. Pikuz, K. Naughton, L. Romagnani, C. Riconda, G. Revet, R. Riquier, H.-P. Schlenvoigt, I. Yu. Skobelev, A.Ya. Faenov, A. Soloviev, M. Huarte-Espinosa, A. Frank, O. Portugall, H. Pépin, J. Fuchs (Source: Science: Current Issue)
Source: Science: Current Issue - October 17, 2014 Category: Science Authors: B. Albertazzi Source Type: research

Young maternal age and old paternal age induce similar risk of mental disorders in offspring
What is already known on this topic? There is robust evidence of an increased risk for autism, schizophrenia and learning disabilities in children born to older fathers, and an increased risk for Down's syndrome in children born to older mothers.1 Advanced parental age may prompt mental disorders in the offspring via de novo mutations in the male germline or chromosomal abnormalities in the female gamete.2 On the other hand, the children of young parents more frequently display conduct disorders and poor outcomes, such as substance use or academic problems, a finding that has been attributed to the socioeconomic deprivatio...
Source: Evidence-Based Mental Health - October 17, 2014 Category: Psychiatry & Psychology Authors: Lopez-Castroman, J. Tags: Neurology, Autism, Pervasive developmental disorder, Conduct disorder, Bipolar disorder, Schizophrenia spectrum, Competing interests (ethics) Causes and risk factors Source Type: research

Ziprasidone monotherapy is ineffective for bipolar-associated anxiety
What is already known on this topic? Anxiety disorders are common among patients with bipolar disorder. Bipolar patients with anxiety disorders have poorer treatment outcomes, greater numbers of suicide attempts, higher rates of substance abuse and lower quality of life.1 Complicating treatment, standard antianxiety agents, such as antidepressants, may worsen the course of bipolar disorder, and there is conflicting evidence about antipsychotics. Some data support the use of quetiapine2 or olanzapine for the treatment of bipolar anxiety, while one trial found risperidone to be ineffective.3 What does this paper add? Ziprasi...
Source: Evidence-Based Mental Health - October 17, 2014 Category: Psychiatry & Psychology Authors: Dunlop, B. W. Tags: Neurology, Substance dependence, Drugs: psychiatry, Bipolar disorder, Suicide (psychiatry), Competing interests (ethics) Pharmacological interventions Source Type: research

Dystonia - Possible Side Effect of Antipsychoti...
Dystonia - a movement disorder that causes abnormal movements or postures - can be a side effect of certain psychiatric medications. More... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 17, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What Is a Sociopath? 3 Vicious Examples
Ted Kaczynski, better known as the Unabomber, was a vicious sociopath whose crime spree lasted more than 20 years. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 17, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Are You Having Racing Thoughts? Here’s...
When a bipolar person has racing thoughts, it doesn't mean he or she is just thinking quickly. Racing thoughts can be very uncomfortable and disturbing. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 17, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Quantitative EEG and Current Source Density Analysis of Combined Antiepileptic Drugs and Dopaminergic Agents in Genetic Epilepsy: Two Case Studies.
This study presents preliminary evidence for a neurophysiologic approach to patients with absence epilepsy and comorbid disorders and may provide a method for further research. PMID: 25326290 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - October 17, 2014 Category: Neuroscience Authors: Emory H, Wells C, Mizrahi N Tags: Clin EEG Neurosci Source Type: research

Neuro-cognitive functioning in unaffected siblings of patients with bipolar disorder: Comparison with bipolar patients and healthy controls.
CONCLUSION: Verbal memory can serve as an endophenotype of bipolar disorder. PMID: 25316940 [PubMed] (Source: Indian Journal of Psychiatry)
Source: Indian Journal of Psychiatry - October 16, 2014 Category: Psychiatry Tags: Indian J Psychiatry Source Type: research

Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression.
Abstract Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed a review on the involvement of cytokines in BD. We also discuss the cytokines involvement in the neuroprogression of BD. It has been demonstrated that increased expression of cytokines in the central nervous system in pos...
Source: Neural Plasticity - October 16, 2014 Category: Neurology Authors: Barbosa IG, Bauer ME, Machado-Vieira R, Teixeira AL Tags: Neural Plast Source Type: research

Long-Term Clinical Outcomes from a Randomized Controlled Trial of Two Implementation Strategies to Promote Collaborative Care Attendance in Community Practices
Abstract This randomized controlled implementation study compared the effectiveness of a standard versus enhanced version of the replicating effective programs (REP) implementation strategy to improve the uptake of the life goals-collaborative care model (LG-CC) for bipolar disorder. Seven community-based practices (384 patient participants) were randomized to standard (manual/training) or enhanced REP (customized manual/training/facilitation) to promote LG-CC implementation. Participants from enhanced REP sites had no significant changes in primary outcomes (improved quality of life, reduced functioning or mood s...
Source: Administration and Policy in Mental Health and Mental Health Services Research - October 16, 2014 Category: Psychiatry Source Type: research

Cochrane Depression, Anxiety and Neurosis Group supports launch of priority-setting initiative for bipolar research in the UK
A new UK-wide survey about bipolar has been launched by a partnership of mental health groups, supported by the Cochrane Depression, Anxiety, and Neurosis Group.The survey gives individuals, families, clinicians and other professionals the opportunity to influence research into the causes, diagnosis, treatment and care of bipolar.The survey has been developed by the James Lind Alliance Bipolar Priority Setting Partnership (PSP) with partners including charities, research funders, clinicians and service users.  External link for more information:  http://www.ouh.nhs.uk/bipolar Con...
Source: The Cochrane Collaboration - Current news at The Cochrane Collaboration - October 15, 2014 Category: Databases & Libraries Authors: Nancy Owens Tags: Current news Cochrane contributors Evidence-based health care Funding & Partnerships Events Source Type: news

Ketamine’s effectiveness in unipolar versus bipolar depression
(Source: Psychopharmacology)
Source: Psychopharmacology - October 15, 2014 Category: Psychiatry Source Type: research

The Story Behind Demi Lovato’s Bipolar...
Teen idol Demi Lovato hid a troubled life for a long time, concealing issues with self-injury by cutting and bulimia, an eating disorder. While in treatment for those issues, she was diagnosed with bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 15, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What's a Sociopath? 4 Frightening Female Serial...
Four female serial killers, all of whom demonstrated a large number of sociopathic symptoms: Aileen Wuornos, Martha Wise, Genene Jones and Kate Bender. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 15, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What's the RIGHT Thing to Say to Someone With...
People who have bipolar talk about the best things others could say to them when their moods have taken control of them. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - October 15, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Receptive field properties of bipolar cell axon terminals in direction-selective sublaminas of the mouse retina
Retinal bipolar cells (BCs) transmit visual signals in parallel channels from the outer to the inner retina, where they provide glutamatergic inputs to specific networks of amacrine and ganglion cells. Intricate network computation at BC axon terminals has been proposed as a mechanism for complex network computation, such as direction selectivity, but direct knowledge of the receptive field property and the synaptic connectivity of the axon terminals of various BC types is required in order to understand the role of axonal computation by BCs. The present study tested the essential assumptions of the presynaptic model of di...
Source: Journal of Neurophysiology - October 15, 2014 Category: Neurology Authors: Chen, M., Lee, S., Park, S. J. H., Looger, L. L., Zhou, Z. J. Tags: Sensory Processing Source Type: research

Intensive ketamine use for multiple years: A case report.
Abstract Ketamine is known within the medical field for its anesthetic properties, yet its unique psychedelic and antidepressant properties are being increasingly recognized. We document the case of a patient with bipolar I disorder and an extensive history of substance dependence who used large doses of ketamine (1-3 g) on a daily basis over a period of 5 years, and described acute antidepressant effects as well as diminished cravings for alcohol. While his use was untenable and ultimately led to an inpatient admission, it is notable that he did not experience a withdrawal syndrome nor did he have any observable...
Source: The American Journal on Addictions - October 15, 2014 Category: Addiction Authors: Liu JX, Zerbo E, Ross S Tags: Am J Addict Source Type: research

Distinguishing Bipolar Disorder From Other Psychiatric Disorders in Children
Abstract Pediatric onset bipolar disorder (BD) is a challenging diagnosis with potentially debilitating outcomes. This review aims to critically evaluate recently published literature relevant to the diagnosis of BD in youth, emphasizing interesting and important new findings characterizing pediatric BD and reporting updates in the diagnostic and statistical manual relevant to this disorder in youth. Challenges regarding the diagnosis of BD will be discussed, in addition to important distinctions with other childhood disorders, including other bipolar spectrum disorders; major depressive disorder; dysthymia; disr...
Source: Current Psychiatry Reports - October 14, 2014 Category: Psychiatry Source Type: research

Antipsychotic exposure prior to acute myocardial infarction in patients with serious mental illness
ConclusionThese findings are consistent with a short‐term risk effect of antipsychotic exposure on risk of AMI and identify potentially vulnerable groups. Further research is required to clarify underlying biological mechanisms. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - October 14, 2014 Category: Psychiatry Authors: S.‐I. Wu, K.‐L. Kao, S.‐C. Chen, J. J. M. Juang, C.‐J. Lin, C.‐K. Fang, C.‐S. Wu, M. Dewey, M. J. Prince, R. Stewart Tags: Original Article Source Type: research

People with Serious Mental Illnesses in Criminal Justice System - New Approaches Needed
In many ways, the criminal justice system is the largest provider of mental health services in the country. Estimates vary, but previous research has found that about 14 percent of persons in the criminal justice system have a serious mental illness, and that number is as high as 31 percent for female inmates. Researchers are defining serious mental illnesses to include such things as schizophrenia, bipolar spectrum disorders and major depressive disorders. (Source: Disabled World)
Source: Disabled World - October 14, 2014 Category: Disability Tags: Cognitive Source Type: news

Intracallosal nNOSneurons co‐localize with NK1 substance P receptor in the rat
Abstract The corpus callosum (cc) contains nitric oxide (NO)‐producing neurons. Since NO is a potent vasodilator, these neurons could translate neuronal signals into vascular responses that can be detected by functional brain imaging. Substance P (SP), one of the most widely expressed peptides in the central nervous system (CNS), also produces vasomotor responses by inducing calcium release from intracellular stores through its preferred neurokinin 1 (NK1) receptor, thus inducing NO production via activation ofneuronal NO synthase (nNOS). Single and double‐labeling (DL) experiments were performed to establish whether N...
Source: The Journal of Comparative Neurology - October 14, 2014 Category: Neurology Authors: Paolo Barbaresi, Emanuela Mensà, Vincenzo Lariccia, Genni Desiato, Mara Fabri, Santo Gratteri Tags: Research Article Source Type: research

Rare genetic disease protects against bipolar disorder
(University of Massachusetts Medical School) A team of scientists led by researchers at the University of Massachusetts Medical School and the University of Miami Miller School of Medicine show that a rare genetic dwarfism called Ellis van-Creveld syndrome protects against bipolar disorder. Thanks to the discovery, they have identified what is likely a key genetic pathway underlying bipolar disorder, a breakthrough that could lead to better drugs for treating bipolar affective disorder, as well as depression and other related mood disorders. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 14, 2014 Category: Global & Universal Source Type: news

Wake-Promoting Pharmacotherapy for Psychiatric Disorders
Abstract Medications promoting wakefulness are currently used in psychopharmacology in different contexts and with different objectives. In particular, they may be used for the treatment of syndromes that primarily show significant impairment in alertness/wakefulness (e.g., excessive sleepiness and other sleep disorders) as well as for the symptomatic treatment of different neuropsychiatric disorders that, in turn, are not exclusively characterized by sleep-wake disturbances (like mood disorders, for instance). In addition, several psychotropic compounds, including some antipsychotics, mood stabilizers, antidepre...
Source: Current Psychiatry Reports - October 14, 2014 Category: Psychiatry Source Type: research

Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ANK3 gene variation in patients with bipolar disorder and healthy controls
#197;gren & K Funa (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - October 14, 2014 Category: Psychiatry Authors: A HayashiK Le GalK SöderstenD Vizlin-HodzicH ÅgrenK Funa Source Type: research

Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder
p; J A Egeland (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - October 14, 2014 Category: Psychiatry Authors: E I GinnsM GaldzickaR C ElstonY E SongS M PaulJ A Egeland Source Type: research

Factors That Affect Radiofrequency Heat Lesion Size
ConclusionsTip gauge, tip length, temperature, and time substantially affect RF lesion size. (Source: Pain Medicine)
Source: Pain Medicine - October 14, 2014 Category: Anesthesiology Authors: Eric R. Cosman, Joseph R. Dolensky, Ryan A. Hoffman Tags: Original Article Source Type: research

Rice SUV3 is a bidirectional helicase that binds both DNA and RNA
Conclusions: This study is the first direct evidence to show the bipolar DNA helicase activity of OsSUV3 protein. The unique properties of OsSUV3 including its dual helicase activity imply that it could be a multifunctional protein involved in biologically significant process of DNA and RNA metabolisms. These results should make significant contribution towards better understanding of SUV3 protein in plants. (Source: BMC Plant Biology)
Source: BMC Plant Biology - October 14, 2014 Category: Biology Authors: Narendra TutejaMohammed TariqueRenu Tuteja Source Type: research