Medicine RSS Search Engine

Bipolar

This page shows you the latest news and research items in this category.

Imaging Genetics Approaches to Identify Mechanisms in Severe Mental Illness
Schizophrenia, bipolar disorder, and major depressive disorders are heritable serious mental illnesses (SMI). What does this heritability mean? What are the underlying mechanisms? Large genome-wide association studies (GWAS) have identified both shared and unique genetic risk variants for these disorders; however, causal risk variants, their molecular mechanisms, and their effects on brain circuitry are mostly unknown. Targeted, possibly individualized, therapies addressing underlying mechanisms offer the promise of improved functioning and well-being for patients. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 21, 2014 Category: Psychiatry Authors: Steven G. Potkin, Fabio Macciardi, Theo G.M. van Erp Tags: Commentaries Source Type: research

Interface Recombination Current in Type II Heterostructure Bipolar Diodes
ACS Applied Materials & InterfacesDOI: 10.1021/am504454g (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - August 21, 2014 Category: Materials Science Authors: Marius Grundmann, Robert Karsthof and Holger von Wenckstern Source Type: research

The impact of past direct-personal traumatic events on 12-month outcome in first episode psychotic mania: Trauma and early psychotic mania - Daglas R, Conus P, Cotton SM, Macneil CA, Hasty MK, Kader L, Berk M, Hallam KT.
OBJECTIVE: Past traumatic events have been associated with poorer clinical outcomes in people with bipolar disorder. However, the impact of these events in the early stages of the illness remains unclear. The aim of this study was to investigate whether pr... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 21, 2014 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Psychiatric disorders, high-risk behaviors, and chronicity of episodes among predominantly african american homeless chicago youth.
Conclusions. Significant differences were evident between the three time parameters, suggesting that stratification of data by different time variables may benefit homelessness research by identifying meaningful subgroups who may benefit from individualized interventions. PMID: 25130234 [PubMed - in process] (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - August 21, 2014 Category: Global & Universal Authors: Castro AL, Gustafson EL, Ford AE, Edidin JP, Smith DL, Hunter SJ, Karnik NS Tags: J Health Care Poor Underserved Source Type: research

Robin Williams: “I’m Not Manic...
Robin Williams himself denied having either bipolar disorder or clinical depression. In the wake of his suicide, we now know his depression was severe. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What People With Bipolar Are Saying About Robin...
The suicide of Robin Williams hit many with mental illnesses especially hard. Here are some of the things people with bipolar disorder had to say. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Robert Downey, Jr. - Poster Child for...
Actor Robert Downey, Jr. has punctuated a career filled with talent and promise with arrests, imprisonments and time spent in drug rehabilitation. Though he has reportedly been diagnosed with bipolar disorder, nothing has ever been said about his receiving proper treatment for that condition. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Signs of Depression
When taken with other symptoms, increased or decreased appetite and/or quickly gaining or losing weight can be a sign of depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Unipolar Peak‐Negative Voltage as an Endocardial Electrographic Characteristic to Predict Overlying Abnormal Epicardial Substrates in Patients with Right Epicardial Ventricular Tachycardia
ConclusionsIn patients with RV epicardial VT, the presence of unipolar peak‐negative voltage of <1.66 mV in the endocardium predicted the presence of epicardial dense scar (<0.5 mV) and potential ablation targets in the overlying epicardium. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - August 21, 2014 Category: Cardiology Authors: PO‐CHING CHI, YENN‐JIANG LIN, SHIH‐LIN CHANG, LI‐WEI LO, YU‐FENG HU, TZE‐FAN CHAO, FA‐PO CHUNG, JONAN LIAO, TA‐CHUAN TUAN, JEN‐YUAN KUO, JIN‐LONG HUANG, SHIH‐ANN CHEN Tags: Original Article Source Type: research

When a Family Member Commits Suicide
There are many ways for one person to leave another's life. Suicide may be the most painful way for those left behind.read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - August 20, 2014 Category: Psychiatry & Psychology Authors: Rachel Pruchno, Ph.D. Tags: Depression Media Psychiatry bipolar disorder family manic depression mental health mental illness relationship robin williams suicide Source Type: news

Mixed Specifier for Bipolar Mania and Depression: Highlights of DSM-5 Changes and Implications for Diagnosis and Treatment in Primary Care.
Abstract Bipolar disorder, while commonly encountered in the primary care setting, is often misdiagnosed or undiagnosed. In the DSM-IV-TR, patients could be diagnosed as being in a mixed state only if they had concurrent manic and depressive symptoms; while this occurs in some patients, many more experience subsyndromal mixed symptoms that would disqualify a "mixed state" diagnosis. The recently released DSM-5 attempts to capture this large proportion of patients with subsyndromal mixed symptoms with the inclusion of the "mixed specifier." The presence of such subsyndromal mixed symptoms has significant implication...
Source: Primary Care - August 19, 2014 Category: Primary Care Authors: Hu J, Mansur R, McIntyre RS Tags: Prim Care Companion CNS Disord Source Type: research

Acute interventions and referral of patients with bipolar disorder by the psychiatric consultation liaison service in a general hospital in Germany: a retrospective analysis.
CONCLUSIONS: Psychiatric consultations are not frequently requested for bipolar patients compared to those with other psychiatric disorders. However, more than half of the bipolar patients needed further psychiatric treatment in a psychiatric hospital. This finding emphasizes the importance of psychiatric consultations in a general hospital for bipolar patients. The administration of benzodiazepines as an acute treatment seems to be the standard pharmacologic procedure, not a specific pharmacotherapy like mood stabilizers. PMID: 25133062 [PubMed] (Source: Primary Care)
Source: Primary Care - August 19, 2014 Category: Primary Care Authors: Anderson C, Quante A Tags: Prim Care Companion CNS Disord Source Type: research

Lithium-induced fixed drug eruption in a case of bipolar mania.
PMID: 25133053 [PubMed] (Source: Primary Care)
Source: Primary Care - August 19, 2014 Category: Primary Care Authors: Mehta VS, Raj S, Singh S, Sinha V Tags: Prim Care Companion CNS Disord Source Type: research

Bipolar transurethral vaporization: a superior procedure in benign prostatic hyperplasia: a prospective randomized comparison with bipolar TURP
Conclusions Bipolar TUVP is a safe, effective and low cost procedure among minimally invasive surgeries of BPH. Compared with bipolar TURP, the bipolar TUVP had similar complications, better perioperative and postoperative outcomes, superior hemostasis and higher efficacy. (Source: International Braz J Urol)
Source: International Braz J Urol - August 19, 2014 Category: Urology & Nephrology Source Type: research

Diagnosis and Management of Bipolar Disorder in Primary Care: A DSM-5 Update
This review discusses the diagnosis and detection of bipolar disorder in the primary care population with recent changes introduced by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and the pharmacotherapy and psychosocial management of this psychiatric condition. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - August 19, 2014 Category: Primary Care Authors: Carolyn J. Brenner, Stanley I. Shyn Source Type: research

Psychopharmacology
This article reviews mechanisms of action, indications, dosing, side effects, medication interactions, and general management considerations for common medications used to treat psychiatric conditions encountered in the primary care setting. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - August 19, 2014 Category: Primary Care Authors: L. Renata Thronson, Genevieve L. Pagalilauan Source Type: research

Lovastatin as an adjuvant to lithium for treating manic phase of bipolar disorder: a 4-week, randomized, double-blind, placebo-controlled clinical trial.
Conclusions. Lovastatin neither exacerbated nor decreased the symptoms of mania in patients with bipolar disorder. Current results support that the combination of lovastatin with lithium is tolerated well in bipolar disorder. The trial was registered with the Iranian Clinical Trials Registry (IRCT201302203930N18). PMID: 25132988 [PubMed] (Source: Depression Research and Treatment)
Source: Depression Research and Treatment - August 19, 2014 Category: Psychiatry Tags: Depress Res Treat Source Type: research

Should You Receive Inpatient Psychiatric Care?
The thought of inpatient psychiatric care may be very frightening. Here, from someone who knows, is a detailed description of what you may encounter during inpatient psychiatric care at a hospital. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 19, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Long-Term Follow-Up Shows Excellent Transmural Atrial Lead Performance in Patients With Complex Congenital Heart Disease [Original Articles]
Conclusions— TMA pacing leads had excellent longevity, initial, and chronic functional properties and provide an alternative to epicardial leads in patients with congenital heart disease. Patients who cannot receive transvenous leads, have epicardial scarring or have intra-atrial re-entrant tachycardia could benefit most from routine use of this technique. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - August 19, 2014 Category: Cardiology Authors: Williams, M. R., Shepard, S. M., Boramanand, N. K., Lamberti, J. J., Perry, J. C. Tags: Electrophysiology, Pacemaker, Pediatric and congenital heart disease, including cardiovascular surgery, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Ubiquitous Myocardial Extensions Into the Pulmonary Artery Demonstrated by Integrated Intracardiac Echocardiography and Electroanatomic Mapping: Changing the Paradigm of Idiopathic Right Ventricular Outflow Tract Arrhythmias [Original Articles]
Conclusions— Myocardial voltage extension into the pulmonary artery in humans is ubiquitous and can be demonstrated in vivo using 3-dimensional integrated intracardiac echocardiography to localize the PV. These extensions frequently serve as origins of presumed RVOT arrhythmias; intracardiac echocardiography localization of the PV allows reclassification of these as pulmonary arterial arrhythmias. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - August 19, 2014 Category: Cardiology Authors: Liu, C. F., Cheung, J. W., Thomas, G., Ip, J. E., Markowitz, S. M., Lerman, B. B. Tags: Electrophysiology, Cardiovascular imaging agents/Techniques, Ablation/ICD/surgery, Echocardiography, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Table of Contents
Abstract Antipsychotics found to increase risk of type 2 diabetes in children and adolescents Parents with mood episodes biased in reporting their children's psychopathology Bipolar disorder not necessarily a lifetime chronic condition: Researchers find four subtypes PCP screening and intervention for drugs a failure Underage drinking combined with drugs associated with more serious health outcomes than drinking alone Regular marijuana use harmful for teens' brains: APA CRAN RFI released A warning on the limitations of abuse deterrence (Source: The Brown University Child and Adolescent Psychopharmacology Update)
Source: The Brown University Child and Adolescent Psychopharmacology Update - August 18, 2014 Category: Psychiatry Source Type: research

Green Production of Ultrahigh-Basicity Polyaluminum Salts with Maximum Atomic Economy by Ultrafiltration and Electrodialysis with Bipolar Membranes
Industrial & Engineering Chemistry ResearchDOI: 10.1021/ie5023546 (Source: Industrial and Engineering Chemical Research)
Source: Industrial and Engineering Chemical Research - August 18, 2014 Category: Chemistry Authors: Qing Chen, Chang Xue, Wei-Ming Zhang, Wei-Guo Song, Li-Jun Wan and Kun-Song Ma Source Type: research

Stem cells reveal how illness-linked genetic variation affects neurons
A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports. The study used stem cells generated from people with and without mental illness to observe the effects of a rare and pernicious genetic variation on young brain cells. The results add to evidence that several major mental illnesses have common roots in faulty 'wiring' during early brain development. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 18, 2014 Category: Science Source Type: news

Lipophilic statin use and suicidal ideation in a sample of adults with mood disorders.
Conclusion: Individuals with mood disorders may be susceptible to neuropsychiatric effects of cholesterol-lowering drugs, which warrants further research. (PsycINFO Database Record (c) 2014 APA, all rights reserved) (Source: Crisis: The Journal of Crisis Intervention and Suicide Prevention)
Source: Crisis: The Journal of Crisis Intervention and Suicide Prevention - August 18, 2014 Category: Psychiatry & Psychology Authors: Davison, Karen M.; Kaplan, Bonnie J. Source Type: research

Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II
Bipolar disorder (BD) is a debilitating psychiatric disorder affecting millions of people worldwide with mean time to diagnosis estimated to be at least 10 years. Whilst many brain imaging studies have compared those with BD to controls, few have attempted to investigate differences between BD Type I and II and matched controls. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 18, 2014 Category: Neurology Authors: Jerome J. Maller, Prasanthan Thaveenthiran, Richard H. Thomson, Susan McQueen, Paul B. Fitzgerald Source Type: research

Stem cells reveal how illness-linked genetic variation affects neurons
(Johns Hopkins Medicine) A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports. The study used stem cells generated from people with and without mental illness to observe the effects of a rare and pernicious genetic variation on young brain cells. The results add to evidence that several major mental illnesses have common roots in faulty 'wiring' during early brain development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 17, 2014 Category: Global & Universal Source Type: news

Antidepressant Medications - Box Warning
The United States Food and Drug Administration has ordered that all antidepressants approved by the FDA must carry a boxed warning regarding an increased risk of suicidal thinking and behavior in children and young adults. Here is the text of that warning along with an explanation. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 17, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Why Ecstasy Is a Popular Street Drug for Those...
Facts about the drug Ecstasy and some things to consider if you have an affective disorder including bipolar disorder or major depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 17, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Heinz Prechter - Entrepreneur
The rags-to-riches story of German-American entrepreneur Heinz Prechter is inspirational - but his death revealed a long-fought battle with manic depression that ultimately took his life. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 17, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Robin Williams: Genius and Depression from the Same Well?
Robin Williams’s suicide was no surprise. Both the source of his genius and the source of his depression have been on display to the world all along.read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - August 16, 2014 Category: Psychiatry & Psychology Authors: Jonathan Shedler, PhD Tags: Depression bipolar creativity robin williams suicide Source Type: news

Op-Ed Contributor: Depression Can Be Treated, but It Takes Competence
Depression may be a deadly illness, but we can help people back to life. (Source: NYT Health)
Source: NYT Health - August 16, 2014 Category: Consumer Health News Authors: By KAY REDFIELD JAMISON Tags: Lithium (Drug) Mental Health and Disorders Psychiatry and Psychiatrists Bipolar Disorder Depression (Mental) Anxiety and Stress Source Type: news

Disturbed cortico-amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder.
Authors: Stegmayer K, Usher J, Trost S, Henseler I, Tost H, Rietschel M, Falkai P, Gruber O Abstract Patients suffering from bipolar affective disorder show deficits in working memory functions. In a previous functional magnetic resonance imaging study, we observed an abnormal hyperactivity of the amygdala in bipolar patients during articulatory rehearsal in verbal working memory. In the present study, we investigated the dynamic neurofunctional interactions between the right amygdala and the brain systems that underlie verbal working memory in both bipolar patients and healthy controls. In total, 18 euthymic bipol...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 15, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Mindfulness-based cognitive therapy versus psychoeducational intervention in bipolar outpatients with sub-threshold depressive symptoms: a randomized controlled trial
DiscussionThis is the first randomized controlled trial to evaluate the effects of MBCT compared to an active control group on depressive subthreshold depressive symptoms in patients with bipolar disorder.Trial registrationClinicalTrials.gov: NCT02133170. Registered 04/30/2014. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - August 15, 2014 Category: Epidemiology Authors: Guillermo LaheraCarmen BayónMaria Bravo-OrtizBeatriz Rodríguez-VegaSara BarbeitoMargarita SáenzCaridad AvedilloRosa VillanuevaAmaia UgarteAna González-PintoConsuelo de Dios Source Type: research

What Celebrities Have Bipolar Disease (P to R)?
Found here is the P to R portion of a registry of celebrities who have bipolar disorder (manic depression). In 1993, Joy Ikelman began compiling this list “to provide inspiration for those who have bipolar disorder” and has now passed the torch to the About Bipolar Disorder Guides. The compilation includes both living and deceased celebrities. This registry is a work in progress. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 15, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Jonathan Winters - Comedian, Actor, Artist
Comedian Jonathan Winters has always had a manic element to his humor. According to reports, he has stated that he has bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 15, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What Celebrities Have Bipolar Disorder (U to Z)?
Found here is the U to Z portion of a registry of celebrities who have bipolar disorder (manic depression). In 1993, Joy Ikelman began compiling this list “to provide inspiration for those who have bipolar disorder” and has now passed the torch to the About Bipolar Disorder Guides. The compilation includes both living and deceased celebrities. This registry is a work in progress. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 15, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Distribution and trends in outpatient utilization of generic versus brand name psychopharmaceuticals during a ten-year period in Croatia
Conclusions: The lack of uniform national guidelines and the still strong impact of pharmaceutical industry marketing continue favoring the rise in prescribing brand name antidepressants and antipsychotics. Depression, schizophrenia and bipolar diseases are complex diseases. As a result, specific measures are needed to encourage the prescribing of generic psychopharmaceuticals. (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 15, 2014 Category: Journals (General) Authors: Marina Poli¿-Vi¿intinDanijela ¿timacZvonimir ¿ostarIngrid Tripkovi¿ Source Type: research

Enhanced Neurocognitive Functioning and Positive Temperament in Twins Discordant for Bipolar Disorder.
Conclusions: These findings suggest that supra-normal levels of sociability and verbal functioning may be associated with liability for bipolar disorder. These effects were specific to liability for bipolar disorder and did not apply to schizophrenia. Such benefits may provide a partial explanation for the persistence of bipolar illness in the population. PMID: 25124743 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - August 15, 2014 Category: Psychiatry Authors: Higier RG, Jimenez AM, Hultman CM, Borg J, Roman C, Kizling I, Larsson H, Cannon TD Tags: Am J Psychiatry Source Type: research

Physical and Sexual Abuse and Early-Onset Bipolar Disorder in Youths Receiving Outpatient Services: Frequent, but Not Specific.
The objective of this study was to determine if physical and sexual abuse showed relationships to early-onset bipolar spectrum disorders (BPSD) consistent with findings from adult retrospective data. Participants (N = 829, M = 10.9 years old ± 3.4 SD, 60 % male, 69 % African American, and 18 % with BPSD), primarily from a low socio-economic status, presented to an urban community mental health center and a university research center. Physical abuse was reported in 21 %, sexual abuse in 20 %, and both physical and sexual abuse in 11 % of youths with BPSD. For youths without BPSD, physical abuse was repor...
Source: Journal of Abnormal Child Psychology - August 15, 2014 Category: Psychiatry & Psychology Authors: Du Rocher Schudlich T, Youngstrom EA, Martinez M, KogosYoungstrom J, Scovil K, Ross J, Feeny NC, Findling RL Tags: J Abnorm Child Psychol Source Type: research

What Robin Williams’ Death Tells Us About Parkinson’s Disease
The death of iconic comedian Robin Williams is still fresh in the minds and hearts of the public, with memorials and acts of remembrance taking place across the country. Williams passing has also shed light on his overall health; both mental and physical. Following Williams apparent suicide by hanging, questions about his battle with depression began surfacing, shedding light on a mental health issue that many turn a blind eye to or simply don’t know how to address. However, a statement provided by Williams’ wife Susan Schneider revealed another personal battle the world-class comedian was facing: Parkinson’s Disease...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 14, 2014 Category: Consumer Health News Authors: cbskapost Tags: Entertainment Health Celebrity Deaths Depression Michael J. Fox Muhammad Ali Parkinson's Disease Suicide Source Type: news

Risk and information evaluation of prioritized genes for complex traits: Application to bipolar disorder
Many susceptibility genes for complex traits were identified without conclusive findings. There is a strong need to integrate rapidly accumulated genomic data from multi‐dimensional platforms, and to conduct risk evaluation for potential therapeutic and diagnostic usages. We set up an algorithm to computationally search for optimal weight‐vector for various data sources, while minimized potential noises. Through gene‐prioritization framework, combined scores for the resulting prioritized gene‐set were calculated using a genome‐wide association (GWA) dataset, following with evaluation using weighted genetic risk s...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 14, 2014 Category: Genetics & Stem Cells Authors: Chung‐Feng Kao, Li‐Chung Chuang, Po‐Hsiu Kuo Tags: Research Article Source Type: research

3-D Modeling of Humeral Head Defects in Glenohumeral Instability: Clinical Implications of Lesion Morphology and the Glenoid Track Concept
Two-dimensional (2-D) CT scans accurately assess humeral head lesion depth, but consistently underestimate width in all imaging planes [1]. Three-dimensional (3-D) CT reconstructions are recommended to accurately characterize these lesions with respect to size, orientation and morphology. It has been shown in static 3-D models that humeral head lesions that are larger in 2-D size and horizontally-oriented are more likely to engage during dynamic arthroscopic evaluation [2]. The “glenoid track” concept was introduced to identify bipolar bony lesions at risk of interfacing dynamically, but may underestimate the significa...
Source: Journal of Shoulder and Elbow Surgery - August 14, 2014 Category: Orthopaedics Authors: Jaicharan J. Iyengar, Kevin N. Jiang, Dennis Kwon, Evan G. Lustbader, Christopher S. Ahmad Tags: Abstracts Source Type: research

Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway
Conclusions: This study demonstrates that lithium can inhibit LPS-induced TLR4 expression and microglial activation through the PI3K/Akt/FoxO1 signaling pathway. These results suggest that lithium plays an important role in microglial activation and neuroinflammation-related diseases, which may lead to a new therapeutic strategy for the treatment of neuroinflammation-related disorders. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - August 14, 2014 Category: Neurology Authors: Hongquan DongXiang ZhangXiaonan DaiShunmei LuBo GuiWenjie JinSusu ZhangShu ZhangYanning Qian Source Type: research

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
With the notable exception of B-cell malignancies, the efficacy of chimeric antigen receptor (CAR) T cells has been limited, and CAR T cells have not been shown to expand and persist in patients with nonlymphoid tumors. Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence. Compared with CARs containing the CD3 chain alone, or in tandem with the CD28 or the 4-1BB intracellular domains, ICOS signaling increased IL-17A, IL-17F, and IL-22 following antigen ...
Source: Blood - August 14, 2014 Category: Hematology Authors: Guedan, S., Chen, X., Madar, A., Carpenito, C., McGettigan, S. E., Frigault, M. J., Lee, J., Posey, A. D., Scholler, J., Scholler, N., Bonneau, R., June, C. H. Tags: Immunobiology, Gene Therapy Source Type: research

Diagnostic and clinical characteristics of early‐manifesting females with Duchenne or Becker muscular dystrophy
Manifestations of Duchenne and Becker muscular dystrophy (DBMD) are present in up to 40% of heterozygous females, but there are few reports of females who exhibit skeletal muscle symptoms in childhood. From the Muscular Dystrophy Surveillance Tracking and Research Network, a multi‐site population‐based surveillance network for dystrophinopathy, nine symptomatic female heterozygotes with onset of symptoms prior to age 9 years were identified. The median age at diagnosis was 8.3 years, and the median interval from first symptoms to diagnosis was 1.35 years. Of the nine female heterozygotes, four had a positive family his...
Source: American Journal of Medical Genetics Part A - August 14, 2014 Category: Genetics & Stem Cells Authors: Lauren Imbornoni, Elinora T. Price, Jennifer Andrews, F. John Meaney, Emma Ciafaloni, Christopher Cunniff Tags: Research Article Source Type: research

Reduced Dopamine Transporter Expression in the Amygdala of Subjects Diagnosed With Schizophrenia
A disruption of dopaminergic transmission in the amygdala of subjects with schizophrenia was proposed as a main contributor to pathophysiological and clinical manifestations of this disorder. We tested the hypothesis that the expression of the dopamine transporter (DAT) is decreased in the amygdala of subjects with schizophrenia. In normal control, schizophrenic subjects and bipolar disorder subjects, we measured numerical density of axon varicosities immunoreactive (IR) for DAT in the lateral (LN), basal, accessory basal (ABN), and cortical (CO) nuclei and intercalated cell masses (ITCM) of the amygdala. Tyrosine hydroxyl...
Source: Schizophrenia Bulletin - August 14, 2014 Category: Psychiatry Authors: Markota, M., Sin, J., Pantazopoulos, H., Jonilionis, R., Berretta, S. Tags: Regular Article Source Type: research

Elevated Antisaccade Error Rate as an Intermediate Phenotype for Psychosis Across Diagnostic Categories
Conclusions: These findings indicate that elevated antisaccade error rate represents an intermediate phenotype for psychosis across diagnostic categories, and that it tracks risk beyond that attributable to the generalized cognitive deficit. The greater severity of antisaccade impairment in schizophrenia and its independence from attention shifting processes suggest more severe and specific prefrontal inhibitory control deficits in this disorder. (Source: Schizophrenia Bulletin)
Source: Schizophrenia Bulletin - August 14, 2014 Category: Psychiatry Authors: Reilly, J. L., Frankovich, K., Hill, S., Gershon, E. S., Keefe, R. S. E., Keshavan, M. S., Pearlson, G. D., Tamminga, C. A., Sweeney, J. A. Tags: Regular Article Source Type: research

The influence of cognitive reserve on psychosocial and neuropsychological functioning in bipolar disorder
Cognitive Reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain pathology in order to minimize symptomatology. CR was initially investigated in dementia and acute brain damage, but it is being applied to other neuropsychiatric conditions. The present study aims at examining the fit of this concept to a sample of euthymic bipolar patients compared with healthy controls in order to investigate the role of CR in predicting psychosocial and cognitive outcome in bipolar disorder (BD). (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - August 14, 2014 Category: Psychiatry & Psychology Authors: Irene Forcada, Maria Mur, Ester Mora, Eduard Vieta, David Bartrés-Faz, Maria J. Portella Source Type: research

Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances
In this study we aimed to identify a “cognitive deficit” vs. “non-deficit” subgroup within BD by using an extensive neuropsychological test battery. The test performance of 70 euthymic outpatients (BD-I and II, recruited as a sample of convenience from our bipolar disorder program) was compared to 70 matched, healthy controls (HC). (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - August 14, 2014 Category: Psychiatry & Psychology Authors: J. Volkert, J. Kopf, J. Kazmaier, F. Glaser, K.C. Zierhut, M.A. Schiele, S. Kittel-Schneider, A. Reif Source Type: research

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder
Bipolar disorder (BD) has been associated with right hemisphere dysfunction. These findings usually come from studies that have not distinguished between symptomatic and euthymic states of BD. The present study aims to investigate atypical right (and left) hemispheric functioning in euthymic BD patients. We evaluated 40 participants (18 healthy controls and 22 euthymic BD patients) using an emotional prosody dichotic listening task and a linguistic dichotic listening task which have been shown to produce a strong left ear advantage (LEA) and right ear advantage (REA), indicating a right and left hemisphere superiority, res...
Source: Psychiatry Research - August 14, 2014 Category: Psychiatry Authors: Pablo Najt, Markus Hausmann Source Type: research