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Three New neuroscienceCME Snacks in Depression, Bipolar Depression,...
Three neuroscienceCME Snacks Now Available Online For Physicians Seeking Credit; Featuring Expert Faculty Alan Schatzberg, MD, Charles Nemeroff, MD, Joseph Calabrese, MD, Mark Frye, MD, and Anand...(PRWeb February 05, 2016)Read the full story at http://www.prweb.com/releases/2016/02/prweb13202431.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 7, 2016 Category: Pharmaceuticals Source Type: news

A photocatalytic graphene quantum dots-Cu2O/bipolar membrane as a separator for water splitting
New J. Chem., 2016, Advance ArticleDOI: 10.1039/C5NJ03604F, PaperXian Liu, Xuan Jian, Huimin Yang, Xiuli Song, Zhenhai LiangA novel graphene quantum dots-Cu2O/bipolar membrane was used for water splitting with photoelectron-synergistic catalysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - February 6, 2016 Category: Chemistry Authors: Xian Liu Source Type: research

The microtubular cytoskeleton of olfactory neurons derived from patients with schizophrenia or with bipolar disorder: Implications for biomarker characterization, neuronal physiology and pharmacological screening
Publication date: Available online 4 February 2016 Source:Molecular and Cellular Neuroscience Author(s): G. Benítez-King, M. Valdés-Tovar, C. Trueta, T. Galván-Arrieta, J. Argueta, S. Alarcón, A. Lora-Castellanos, H. Solís-Chagoyán Schizophrenia (SZ) and Bipolar Disorder (BD) are highly inheritable chronic mental disorders with a worldwide prevalence of around 1%. Despite that many efforts had been made to characterize biomarkers in order to allow for biological testing for their diagnoses, these disorders are currently detected and classified only by clinical appraisal based on the Diagnostic and Statistic...
Source: Molecular and Cellular Neuroscience - February 6, 2016 Category: Neuroscience Source Type: research

Regulation of Memory Formation by the Transcription Factor XBP1
Publication date: Available online 4 February 2016 Source:Cell Reports Author(s): Gabriela Martínez, René L. Vidal, Pablo Mardones, Felipe G. Serrano, Alvaro O. Ardiles, Craig Wirth, Pamela Valdés, Peter Thielen, Bernard L. Schneider, Bredford Kerr, Jose L. Valdés, Adrian G. Palacios, Nibaldo C. Inestrosa, Laurie H. Glimcher, Claudio Hetz Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer’s disease and bipolar disorders. XBP1 is a major regulator of t...
Source: Cell Reports - February 6, 2016 Category: Cytology Source Type: research

Mood stabilizing drugs regulate transcription of immune, neuronal and metabolic pathway genes in Drosophila
Conclusions (i) Transcriptional effects of lithium and VPA in Drosophila S2 cells and heads show significant overlap. (ii) The overlap between transcriptional alterations in peripheral versus neuronal cells at the single gene level is negligible, but at the gene ontology and pathway level considerable overlap can be found. (iii) Lithium and VPA act on evolutionarily conserved pathways in Drosophila and mammalian models. (Source: Psychopharmacology)
Source: Psychopharmacology - February 6, 2016 Category: Psychiatry Source Type: research

The Connection Between Bipolar Disorder and...
Hypersexuality is said to be a symptom of the manic phase of bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - February 6, 2016 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

NICE guidance on psychological treatments for bipolar disorder: searching for the evidence
Publication date: Available online 5 February 2016 Source:The Lancet Psychiatry Author(s): Sameer Jauhar, Peter J McKenna, Keith R Laws The recent National Institute for Health and Care Excellence guidelines for bipolar disorder offer a number of recommendations for the psychological treatment of bipolar disorder. Scrutiny of the evidence on which these guidelines are based reveals significant flaws in the methodology and conduct of the relevant meta-analyses, and calls into question the interpretation of the evidence. (Source: The Lancet Psychiatry)
Source: The Lancet Psychiatry - February 6, 2016 Category: Psychiatry Source Type: research

Temperament, character and suicide attempts in unipolar and bipolar mood disorders - Jylhä PJ, Rosenström T, Mantere O, Suominen K, Melartin TK, Vuorilehto MS, Holma MK, Riihimäki KA, Oquendo MA, Keltikangas-Järvinen L, Isometsä ET.
OBJECTIVE: Personality features may indicate risk for both mood disorders and suicidal acts. How dimensions of temperament and character predispose to suicide attempts remains unclear. METHOD: Patients (n = 597) from 3 prospective cohort studies (V... (Source: SafetyLit)
Source: SafetyLit - February 5, 2016 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Scientists discover molecular link between psychiatric disorders and type 2 diabetes
Scientists show that a gene called 'DISC1,' which is believed to play a role in mental health disorders, such as schizophrenia, bipolar disorder and some forms of depression, influences the function of pancreatic beta cells which produce insulin to maintain normal blood glucose levels. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 5, 2016 Category: Science Source Type: news

Complementary resistive switching behaviors evolved from bipolar TiN/HfO2/Pt device
In this letter, the dynamic evolution of TiN/HfO2/Pt device from bipolar resistive switching (BRS) to complementary resistive switching (CRS) was reported. The device exhibits the uniform BRS with long retention, good endurance, and self-compliance characteristics after the asymmetric two-step electroforming. However, BRS of the device eventually transforms to CRS after the transitional processes through controlling the compliance current. Meanwhile, the effective barrier height rises up accordingly as the device evolves from BRS to CRS. These superior resistive switching performances of TiN/HfO2/Pt device here can be eluc...
Source: Applied Physics Letters - February 5, 2016 Category: Physics Authors: Xinman Chen, Wei Hu, Yan Li, Shuxiang Wu and Dinghua Bao Source Type: research

Mechanisms underlying the benefits of anticonvulsants over lithium in the treatment of bipolar disorder
Close to 3% of the world’s population suffers from bipolar disease (I and II). Of this 3%, bipolar disease affects largely women (∼3 : 2 compared with men). The median age of diagnosis is 25 in women and even lower in men. A diagnosis of bipolar disease is an expensive psychiatric diagnosis, costing patients more than twice as much money as a diagnosis of unipolar depression. Bipolar I is characterized by one or more manic or mixed episodes, with both mania and depression occurring each day for at least 1 week, whereas bipolar II is characterized by one or more major depressive episode and at least one episode of h...
Source: NeuroReport - February 5, 2016 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Bipolar plasma vaporization using plasma-cutting and plasma-loop electrodes versus cold-knife transurethral incision for the treatment of posterior urethral stricture: a prospective, randomized study
CONCLUSIONS: The application of bipolar plasma-cutting and plasma-loop electrodes for the management of urethral stricture disease is a safe and reliable method that minimizes the morbidity of urethral stricture resection. The advantages include a lower recurrence rate and shorter operative time compared to the cold-knife technique. (Source: Clinics)
Source: Clinics - February 5, 2016 Category: Journals (General) Source Type: research

Actress fights bipolar disorder stigma with comedy
Victoria Maxwell had her first psychotic episode, ironically enough, after attending a meditation retreat. (Source: CNN.com - Health)
Source: CNN.com - Health - February 5, 2016 Category: Consumer Health News Source Type: news

Scientists discover molecular link between psychiatric disorders and type 2 diabetes
(Federation of American Societies for Experimental Biology) In a new report appearing in the Feb. 2016 issue of The FASEB Journal, scientists show that a gene called 'DISC1,' which is believed to play a role in mental health disorders, such as schizophrenia, bipolar disorder and some forms of depression, influences the function of pancreatic beta cells which produce insulin to maintain normal blood glucose levels. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 5, 2016 Category: Global & Universal Source Type: news

Alternating bipolar field stimulation identifies muscle fibers with defective excitability but maintained local Ca2+ signals and contraction
Most cultured enzymatically dissociated adult myofibers exhibit spatially uniform (UNI) contractile responses and Ca2+ transients over the entire myofiber in response to electric field stimuli of either polarity ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 5, 2016 Category: Research Authors: Erick O. Hernández-Ochoa, Camilo Vanegas, Shama R. Iyer, Richard M. Lovering and Martin F. Schneider Source Type: research

Multi-mode resistive switching behaviors induced by modifying Ti interlayer thickness and operation scheme
Publication date: 15 May 2016 Source:Journal of Alloys and Compounds, Volume 667 Author(s): M.J. Wang, F. Zeng, S. Gao, C. Song, F. Pan To overcome the practical issues existed in RRAMs application, complementary resistive switching (CRS) and self-compliance effect are investigated to alleviate sneak current issue and avoid external compliance current (I comp), respectively. It is remarkable that the two resistive switching (RS) behaviors are attempted to achieve in the same system of Pt/HfO2(7.5−x)/Ti(2x)/HfO2(7.5−x)/Pt (x = 0, 2.5, 3.5 nm) device fabricated by magnetron sputtering, i.e., multi-mode resistiv...
Source: Journal of Alloys and Compounds - February 5, 2016 Category: Chemistry Source Type: research

The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis
Data about the prevalence of borderline personality (BPD) and bipolar (BD) disorders comorbidity are scarce and the boundaries remain controversial. We conducted a systematic review and meta-analysis investigating the prevalence of BPD in BD and BD in people with BPD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - February 5, 2016 Category: Neurology Authors: M. Fornaro, L. Orsolini, S. Marini, D. De Berardis, G. Perna, A. Valchera, L. Ganança, M. Solmi, N. Veronese, B. Stubbs Source Type: research

A Time Course Study of Different Methods of Extraneural Scar Induction in a Rat Model
Conclusion We conclude that: (1) the impact of the extraneural scar on the nerve is morphologically and functionally different, based on the method of scarring; (2) to achieve a scar model comparable to the human situation, a method in which the involved nerve is functionally impaired, is preferred over the ones that merely produce a bulky scar.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Journal of Reconstructive Microsurgery)
Source: Journal of Reconstructive Microsurgery - February 5, 2016 Category: Surgery Authors: Zanjani, Leila OriadyFirouzi, MasoumehNabian, Mohammad HosseinZadegan, Shayan AbdollahNategh, MohsenErfanian, RezaAshtiani, Ahmad MohebbiKamrani, Reza Shahryar Tags: Original Article Source Type: research

Elevated midline-parietal gamma band noise power in schizophrenia but not in bipolar patients.
Authors: Suazo V, Lubeiro A, Jurado-Barba R, Moreno-Ortega M, Dompablo M, Morales-Muñoz I, Rodriguez-Jimenez R, Palomo T, Molina V Abstract Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and cognition in schizophrenia. In the current study, we sought to replicate those findings and to study its specificity for schizophrenia in a completely independent ...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 4, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Gabapentin Therapy in Psychiatric Disorders: A Systematic Review.
CONCLUSIONS: Further research is required to better clarify the benefit of gabapentin in psychiatric disorders. PMID: 26835178 [PubMed] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - February 4, 2016 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

A sensitive and practical RP-HPLC-FLD for determination of the low neuroactive amino acid levels in body fluids and its application in depression
Publication date: 11 March 2016 Source:Neuroscience Letters, Volume 616 Author(s): Juan-Li Wu, Si-Yang Yu, Shi-Hua Wu, Ai-Min Bao Ion-exchange high performance liquid chromatography (HPLC) generally fails as a method to determine low levels of free amino acids (AAs) in body fluids. Here we present a modified reversed-phase HPLC (RP-HPLC) protocol for the determination of AAs in body fluids and its application in mood disorder patients. We improved a previous research protocol by modifying i) sample preparation, including deproteination, ii) derivitization, including derivating agent and condition, and iii) sample sep...
Source: Neuroscience Letters - February 4, 2016 Category: Neuroscience Source Type: research

Reply to the Letter to the Editor by Murru et al.
(Source: Bipolar Disorders)
Source: Bipolar Disorders - February 4, 2016 Category: Psychiatry Authors: Hanno Santelmann, Christopher Baethge Tags: Letter to the Editor Source Type: research

Ethnicity and cardiovascular health inequalities in people with severe mental illnesses: protocol for the E-CHASM study
Conclusions There is a dearth of research examining cardiovascular disease in minority ethnic groups with severe mental illnesses. The E-CHASM study will address this knowledge gap. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - February 4, 2016 Category: Psychiatry Source Type: research

Effectiveness of traditional healers in treating mental disorders: a systematic review
Publication date: February 2016 Source:The Lancet Psychiatry, Volume 3, Issue 2 Author(s): Gareth Nortje, Bibilola Oladeji, Oye Gureje, Soraya Seedat Traditional healers form a major part of the mental health workforce worldwide. Despite this, little systematic examination has been done of their effectiveness in treating mental illness or alleviating psychological distress. In this Review, we aim to fill this gap, with a focus on quantitative outcomes. We searched four databases and reference lists for papers that explicitly measured the effectiveness of traditional healers on mental illness and psychological distres...
Source: The Lancet Psychiatry - February 4, 2016 Category: Psychiatry Source Type: research

Impaired glucose metabolism moderates the course of illness in bipolar DISORDER
This study aimed to investigate the moderating effects of impaired glucose metabolism (IGM) on variables of illness course and severity in a BD population. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - February 4, 2016 Category: Neurology Authors: Rodrigo B. Mansur, Lucas B. Rizzo, Camila M. Santos, Elson Asevedo, Graccielle R. Cunha, Mariane N. Noto, Mariana Pedrini, Maiara Zeni, Quirino Cordeiro, Roger S. McIntyre, Elisa Brietzke Source Type: research

Treatment Attendance among Veterans with Depression, Substance Use Disorder, and Trauma.
CONCLUSIONS: Few variables were significantly predictive of treatment attendance, possibly due to the complex nature of comorbid disorders. Including a focus on trauma was not associated with lower attendance. Special consideration may need to be given to education level, homelessness, and trauma when trying to engage and retain patients with comorbid disorders in treatment. This clinical trial is registered at www.ClinicalTrials.gov as NCT00958217. PMID: 26828770 [PubMed - as supplied by publisher] (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - February 3, 2016 Category: Addiction Tags: J Dual Diagn Source Type: research

Top 10 research questions to promote physical activity in bipolar disorders: A consensus statement from the International Organization of Physical Therapists in Mental Health
Research has only recently started to consider the importance and applicability of physical activity (PA) for people with bipolar disorder (BD). The aim of the current study is to highlight 10 pertinent PA research questions in people with BD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - February 3, 2016 Category: Neurology Authors: Davy Vancampfort, Simon Rosenbaum, Michel Probst, Joanne Connaughton, Christy du Plessis, Taisei Yamamoto, Brendon Stubbs Source Type: research

The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders
Previous studies demonstrated levels of serum CK (sCK) in the majority of patients undergoing acute psychosis. Records of 1054 patients hospitalized in Geha Mental Health Center during the study period were analysed. Of them, 743 have been diagnosed with schizophrenia (Sz), 170 with schizoaffective disorder (SzA), and 158 with bipolar disorder (BP-I). Baseline sCK and PANSS values were obtained from each patient upon admission. Our results show that LnsCK is higher in patients with BP-I in comparison with patients with SZ, but not significantly different compared to patients with SzA. (Source: Psychiatry Research)
Source: Psychiatry Research - February 3, 2016 Category: Psychiatry Authors: Sarah Hollander, Eldar Hochman, Gal Shoval, Michal Taler, Sharon Trommer, Haggai Hermesh, Abraham Weizman, Amir Krivoy Source Type: research

Tales from the Couch: A Clinical Psychologist’s True Stories of Psychotherapy
Sitting across from someone in a therapy session is simultaneously intimate and clinical. As the therapist, you must balance a few things at once: develop a diagnostic understanding of the client while also integrating the individual experiences that make each person’s story unique. Having sat on both sides of the therapeutic couch, so to speak, I always look forward to reading about other therapists’ experiences. In his latest book, Tales from the Couch: A Clinical Psychologist’s True Stories of Psychotherapy, clinical psychologist Bob Wendorf lets us inside his office, showing us glimpses of rich clinical relat...
Source: Psych Central - February 2, 2016 Category: Psychiatry Authors: Megan Riddle Tags: Book Reviews Clinicians on the Couch Disorders General Interview Motivation and Inspiration Personal Stories Personality Professional Psychological Assessment Psychology Psychotherapy Therapists Spill a clinical psychologist's tr Source Type: news

Deficient inhibitory control as an outcome of childhood trauma - Marshall DF, Passarotti AM, Ryan KA, Kamali M, Saunders EFH, Pester B, McInnis MG, Langenecker SA.
This study aimed to investigate the performance of bipolar disorder (BD) patients and healthy controls (HC), with or wit... (Source: SafetyLit)
Source: SafetyLit - February 2, 2016 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Genetic Variants Predict Lithium Response in Bipolar DisorderGenetic Variants Predict Lithium Response in Bipolar Disorder
A genome-wide analysis by a global consortium reveals four single-nucleotide polymorphisms on chromosome 21 that could affect responses to lithium in patients with bipolar disorder. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - February 2, 2016 Category: Psychiatry Tags: Psychiatry News Source Type: news

Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia–reperfusion
Publication date: 24 March 2016 Source:Neuroscience, Volume 318 Author(s): H. Ueda, S.K. Halder, H. Matsunaga, K. Sasaki, S. Maeda Prothymosin alpha (ProTα) has robustness roles against brain and retinal ischemia or serum-starvation stress. In the ProTα sequence, the active core 30-amino acid peptide/P30 (a.a.49–78) is necessary for the original neuroprotective actions against ischemia. Moreover, the 9-amino acid peptide sequence/P9 (a.a.52–60) in P30 still shows neuroprotective activity against brain and retinal ischemia, though P9 is less potent than P30. As the previous structure–activity relationship stu...
Source: Neuroscience - February 2, 2016 Category: Neuroscience Source Type: research

Changes in mood stabilizer prescription patterns in bipolar disorder
Lithium is a first line treatment option in bipolar disorder, but several alternative treatments have been introduced in recent years, such as antiepileptic and atypical antipsychotic drugs. Little is known about how this has changed the prescription patterns. We investigated possible changes in the use of mood stabilizers and antidepressants in Sweden during 2007–2013. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - February 2, 2016 Category: Neurology Authors: Alina Karanti, Mathias Kardell, Ulrika Lundberg, Mikael Landén Tags: Research paper Source Type: research

Long-term results of minimally invasive stand-alone bi-atrial surgical ablation with a bipolar ablation device for persistent and longstanding persistent AF: a single-center case series of 91 patients
Conclusions: In the present series, the efficacy of epicardial surgical ablation was similar to that reported previously. The rate of arrhythmia recurrence increased over time. Achieving pulmonary vein isolation is essential to AF elimination. The division of ligament of Marshall could contribute to improved rates of SR restoration in patients with persistent or long-standing persistent AF if PVI is achieved. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - February 2, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Vilius JanusauskasLina PuodziukaiteVyte ManeikieneGitana ZuozieneGreta RadauskaiteGreta BurneikaiteRobertas SamalaviciusSigita AidietieneKestutis RucinskasAudrius Aidietis Source Type: research

NIDS in bipolar disorder with psychosis
Ueda S, Sakayori T, Omori A, Fukuta H, Kobayashi T, Ishizaka K, Saijo T, Okubo Y (Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - February 1, 2016 Category: Psychiatry Source Type: research

Frank Bruno announces boxing comeback as fans question if he is well enough to be on TV
Fans said Bruno's TV interview was 'uncomfortable viewing', but the boxer claimed he was fighting fit (Source: Telegraph Health)
Source: Telegraph Health - February 1, 2016 Category: Consumer Health News Tags: bipolar depression frank bruno boxing comeback this morning tv return Source Type: news

Lipophosphoramidate-based bipolar amphiphiles: syntheses and transfection properties
Org. Biomol. Chem., 2016, Accepted ManuscriptDOI: 10.1039/C5OB02512E, PaperMathieu Berchel, Tony Le GAll, Olivier Lozach, Jean-Pierre Haelters, Tristan Montier, Paul-Alain JaffresSix new cationic bolaamphiphiles (also called bipolar amphiphiles, bolaform amphiphiles, or bolalipids) were readily prepared by thiol-ene click reaction that engaged a mercapto-alcohol (mercapto-ethanol or mercapto-hexanol) and a cationic based...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - February 1, 2016 Category: Molecular Biology Authors: Mathieu Berchel Source Type: research

The Burden of Repeated Mood Episodes in Bipolar I Disorder: Results From the National Epidemiological Survey on Alcohol and Related Conditions
Abstract: The aim of this study was to examine the association between previous mood episodes and clinical course/functioning in a community sample (National Epidemiological Survey on Alcohol and Related Conditions [NESARC]). Subjects (n = 909) met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, criteria for bipolar I disorder and provided data on number of previous episode recurrences. Number of previous mood episodes was used to predict outcomes at wave 1 and wave 2 of the NESARC. Previous mood episodes accounted for small but unique variance in outcomes. Recurrence was associated with poorer function...
Source: The Journal of Nervous and Mental Disease - February 1, 2016 Category: Psychiatry Tags: Original Articles Source Type: research

Safety and Efficacy of a New Bipolar Energy Device for Parenchymal Dissection in Laparoscopic Liver Resection
Background: Despite emerging technologies, parenchymal transection still remains challenging in liver resection. The aim of this study is to assess the safety and efficacy of a new articulating vessel sealer for laparoscopic hepatectomy. Our hypothesis was that this new device would facilitate parenchymal transection and reduce intraoperative costs in laparoscopic hepatectomy. Methods: Within 18 months, a 5 cm bipolar articulating vessel sealer was used in 32 laparoscopic liver resections (LLR). By excluding 4 patients who underwent concomitant colorectal resections, the outcomes of the remaining 28 patients (group 1) wer...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - February 1, 2016 Category: Surgery Tags: Original Articles Source Type: research

Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance [PAPERS]
Conclusions Our findings suggest that 20q11.22 is likely a risk region for bipolar disorder; they also highlight the informative value of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex disorders, such as bipolar disorder. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - February 1, 2016 Category: Psychiatry Authors: Li, M., Luo, X.-j., Landen, M., Bergen, S. E., Hultman, C. M., Li, X., Zhang, W., Yao, Y.-G., Zhang, C., Liu, J., Mattheisen, M., Cichon, S., Mühleisen, T. W., Degenhardt, F. A., Nöthen, M. M., Schulze, T. G., Grigoroiu-Serbanescu, M., Li, Tags: PAPERS Source Type: research

Elevated C-reactive protein and late-onset bipolar disorder in 78 809 individuals from the general population [PAPERS]
Conclusion Elevated CRP is associated with increased risk of late-onset bipolar disorder in the general population which was supported by the genetic analysis. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - February 1, 2016 Category: Psychiatry Authors: Wium-Andersen, M. K., Orsted, D. D., Nordestgaard, B. G. Tags: PAPERS Source Type: research

Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder [PAPERS]
Conclusions Together with our volumetric studies, these results suggest that higher BMI is associated with more pronounced structural and neurochemical limbic brain changes in bipolar disorder, even in early-stage patients with low obesity rates. (Source: The British Journal of Psychiatry)
Source: The British Journal of Psychiatry - February 1, 2016 Category: Psychiatry Authors: Bond, D. J., da Silveira, L. E., MacMillan, E. L., Torres, I. J., Lang, D. J., Su, W., Honer, W. G., Lam, R. W., Yatham, L. N. Tags: PAPERS Source Type: research

CACNA1C polymorphism and altered phosphorylation of tau in bipolar disorder [SHORT REPORTS]
Several genome-wide association studies and case–control studies have associated the single nucleotide polymorphism (SNP) rs1006737, situated in CACNA1C encoding the alpha 1C subunit of the L-type voltage-gated calcium channel, with bipolar disorder and other psychiatric disorders. However, the causal pathway linking genetic variants in CACNA1C with increased risk for developing brain disorders remains unclear. Here, we explored the association between the rs1006737 SNP and cerebrospinal fluid (CSF) markers. We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylate...
Source: The British Journal of Psychiatry - February 1, 2016 Category: Psychiatry Authors: Jakobsson, J., Palsson, E., Sellgren, C., Rydberg, F., Ekman, A., Zetterberg, H., Blennow, K., Landen, M. Tags: SHORT REPORTS Source Type: research

Maintaining Adherence Programme: evaluation of an innovative service model [Original papers]
Aims and method The Maintaining Adherence Programme (MAP) is a new model of care for patients with schizophrenia, schizoaffective disorder and bipolar affective disorder which aims to encourage adherence and prevent relapse. This evaluation, conducted by retrospective and prospective data collection (including patient questionnaires and staff interviews), aimed to describe MAP's impact on healthcare resource use, clinical measures and patient and staff satisfaction, following its implementation in a university National Health Service (NHS) foundation trust in England. We included 143 consenting patients who entered MAP bef...
Source: Psychiatric Bulletin - February 1, 2016 Category: Psychiatry Authors: Lewis, L., O'Keeffe, C., Smyth, I., Mallalieu, J., Baldock, L., Oliver, S. Tags: Original papers Source Type: research

Differential Prevalence and Demographic and Clinical Correlates of Second-Generation Antipsychotic Use in Bipolar I versus Bipolar II Disorder
Conclusions Current SGA use was robustly associated with prior psychiatric hospitalization in BDI and to a more limited extent with current mood stabilizer use in BDII. SGA use associations with other unfavorable illness characteristics in BDI were less robust. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - February 1, 2016 Category: Psychiatry Source Type: research

Elevated midline-parietal gamma band noise power in schizophrenia but not in bipolar patients
Abstract Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and cognition in schizophrenia. In the current study, we sought to replicate those findings and to study its specificity for schizophrenia in a completely independent sample. A principal component analysis (PCA) was used to determine the factorial structure of gamma noise power acquired with an el...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 1, 2016 Category: Neuroscience Source Type: research

Clinical efficacy and safety of repetitive transcranial magnetic stimulation in acute bipolar depression.
PMID: 26833619 [PubMed] (Source: World Psychiatry)
Source: World Psychiatry - February 1, 2016 Category: Psychiatry Authors: McGirr A, Karmani S, Arsappa R, Berlim MT, Thirthalli J, Muralidharan K, Yatham LN Tags: World Psychiatry Source Type: research

Lithium vs. valproate vs. olanzapine vs. quetiapine as maintenance monotherapy for bipolar disorder: a population-based UK cohort study using electronic health records.
Abstract It is unclear which maintenance treatment for bipolar disorder is superior in clinical practice. Randomized controlled head-to-head trials of available drugs either do not exist or are inconclusive. We aimed to compare rates of monotherapy treatment failure in individuals prescribed lithium, valproate, olanzapine or quetiapine by a population-based cohort study using electronic health records. 5,089 patients with bipolar disorder were prescribed lithium (N=1,505), valproate (N=1,173) olanzapine (N=1,366) or quetiapine (N=1,075) as monotherapy. Treatment failure was defined as time to stopping medication or...
Source: World Psychiatry - February 1, 2016 Category: Psychiatry Authors: Hayes JF, Marston L, Walters K, Geddes JR, King M, Osborn DP Tags: World Psychiatry Source Type: research

The Prevalence and Diagnostic Validity of Short-Duration Hypomanic Episodes and Major Depressive Episodes
Abstract Current diagnostic criteria for a hypomanic episode, as outlined in both the fourth and fifth editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV and DSM-5), require a minimum duration of four consecutive days of symptoms of mood elevation. The 4-day criterion for duration of hypomania has been challenged as arbitrary and lacking empirical support, with many arguing that shorter-duration hypomanic episodes are highly prevalent and that those experiencing these episodes are clinically more similar to patients with bipolar disorder than to those with unipolar major depressive diso...
Source: Current Psychiatry Reports - February 1, 2016 Category: Psychiatry Source Type: research

Trajectories of ADHD severity over 10 years from childhood into adulthood
Abstract The study examined unique trajectories of ADHD severity from childhood (7–16 yo at baseline) through adulthood in a sample of ADHD, bipolar and healthy subjects. Comorbid disorders and temperament were examined as correlates of course of ADHD. N = 81 participants with an ADHD diagnosis, ascertained as a comparison group in a study of bipolar disorder (BP-I), were followed over a 10-year period. Growth mixture modeling (GMM) of ADHD severity was used to investigate trajectories of ADHD severity over 10 years. GMM revealed four trajectories in the N = 251 participants included in these analyses. A pe...
Source: ADHD Attention Deficit and Hyperactivity Disorders - February 1, 2016 Category: Psychiatry Source Type: research