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Effects of asenapine in bipolar I patients meeting proxy criteria for moderate-to-severe mixed major depressive episodes: a post hoc analysis.
CONCLUSIONS: These data provide support for the potential efficacy of asenapine in mixed major depressive episodes; however, these data cannot be linearly extrapolated to nonmixed major depression. PMID: 25612216 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 26, 2015 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical risk factors and serotonin transporter gene variants associated with antidepressant-induced mania.
DISCUSSION: Narrowly defined, AIM appears to be at greatest risk for bipolar I patients. Our haplotype analysis of SLC6A4 suggests that future pharmacogenetic studies should not only focus on the SLC6A4 promotor variation but also investigate the role of other variants in the gene. PMID: 25611077 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 26, 2015 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Adverse childhood events and psychosis in bipolar affective disorder.
Conclusions Within affective disorder, the relationship between childhood events and psychosis appears to be relatively symptom-specific. It is possible that the pathways leading to psychotic symptoms differ, with delusions and non-hallucinatory symptoms being influenced less by childhood or early environmental experience. PMID: 25614532 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - January 26, 2015 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Lithium treatment and risk for dementia in adults with bipolar disorder: population-based cohort study.
Conclusions Continuous lithium treatment may reduce dementia risk in older adults with bipolar disorder. PMID: 25614530 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - January 26, 2015 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Tramadol-related psychosis in a patient with bipolar I disorder.
CONCLUSIONS: Tramadol HCl is commonly prescribed in clinical practice and psychotic symptoms related to it are uncommon. We should be careful about the rare but important adverse events while prescribing tramadol HCl. PMID: 25603153 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 26, 2015 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Bipolar Disorder: Role of Immune-Inflammatory Cytokines, Oxidative and Nitrosative Stress and Tryptophan Catabolites
Abstract Bipolar disorder (BD) is a complex disorder with a range of presentations. BD is defined by the presentation of symptoms of mania or depression, with classification dependent on patient/family reports and behavioural observations. Recent work has investigated the biological underpinnings of BD, highlighting the role played by increased immune-inflammatory activity, which is readily indicated by changes in pro-inflammatory cytokines or signalling, both centrally and systemically, e.g. increased interleukin-6 trans-signalling. Here, we review the recent data on immune-inflammatory pathways and cytokine cha...
Source: Current Psychiatry Reports - January 26, 2015 Category: Psychiatry Source Type: research

Suicidal behavior: Epidemiology
O Brasil encontra-se entre os dez países que registram os maiores números absolutos de suicídios, com 9.852 mortes em 2011. O coeficiente médio para o período 2004-2010 foi de 5,7%. Esse índice aumentou 29,5% nas duas últimas décadas e é mais elevado em homens, idosos, indígenas e em cidades de pequeno e de médio porte populacional. Transtornos mentais encontram-se presentes na maioria dos casos de suicídio, principalmente depressão, transtorno do humor bipolar e dependência de álcool e de outras drogas psicoativas. Um estudo populacional revelou que, ao longo da vid...
Source: Psicologia USP - January 25, 2015 Category: Psychiatry & Psychology Source Type: research

Issue Information
(Source: Bipolar Disorders)
Source: Bipolar Disorders - January 25, 2015 Category: Psychiatry Tags: Issue Information Source Type: research

Fall Out Boy Singer Pete Wentz Opens Up About His Battle With Bipolar Disorder
For the millions of people who have been touched by some form mental illness, Pete Wentz has a message for you: It's OK to open up. The Fall Out Boy singer joined HuffPost Live's Caroline Modarressy-Tehrani earlier this week, where they discussed mental health stigma and the common misconceptions about what it means to treat the disorders. While many who struggle with mental illness believe that they'll be on medication or in therapy forever, Wentz stressed that everyone's journey is different. "I think that the idea there's a 'one-size-fits-all' [treatment] is one of those myths," Wentz said. "Everybody figures themselv...
Source: Healthy Living - The Huffington Post - January 24, 2015 Category: Consumer Health Advice Source Type: news

Fall Out Boy Bassist Pete Wentz Opens Up About His Battle With Bipolar Disorder
For the millions of people who have been touched by some form mental illness, Pete Wentz has a message for you: It's OK to open up. The Fall Out Boy bassist joined HuffPost Live's Caroline Modarressy-Tehrani earlier this week, where they discussed mental health stigma and the common misconceptions about what it means to treat the disorders. While many who struggle with mental illness believe that they'll be on medication or in therapy forever, Wentz stressed that everyone's journey is different. "I think that the idea there's a 'one-size-fits-all' [treatment] is one of those myths," Wentz said. "Everybody figures themsel...
Source: Healthy Living - The Huffington Post - January 24, 2015 Category: Consumer Health Advice Source Type: news

Doubts about the crucial role of the rising-tube mechanism in the formation of sunspot groups
Publication date: 1 February 2015 Source:Advances in Space Research, Volume 55, Issue 3 Author(s): A.V. Getling , R. Ishikawa , A.A. Buchnev Some preliminary processing results are presented for a dataset obtained with the Solar Optical Telescope on the Hinode satellite. The idea of the project is to record, nearly simultaneously, the full velocity and magnetic-field vectors in growing active regions and sunspot groups at a photospheric level. Our ultimate aim is to elaborate observational criteria to distinguish between the manifestations of two mechanisms of sunspot-group formation — the rising of an Ω -shaped flux...
Source: Advances in Space Research - January 24, 2015 Category: Science Source Type: research

Unipolar versus bipolar hemiarthroplasty for displaced femoral neck fractures: a systematic review and meta-analysis of randomized controlled trials
Conclusions: Based on the current evidence, BH is not superior to UH in terms of surgical information and postoperative results. Despite similar or better clinical outcomes compared with UH, BH with a higher cost could not decrease long-term acetabular erosion rate. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - January 24, 2015 Category: Orthopaedics Authors: Zhiwei JiaFan DingYaohong WuWei LiHaifeng LiDeli WangQing HeDike Ruan Source Type: research

The Importance of Anxiety States in Bipolar Disorder
Abstract Anxiety symptoms and syndromes are common in bipolar disorders, occurring in over half of all subjects with bipolar disorder type I. Despite methodological and diagnostic inconsistencies, most studies have shown a robust association between the presence of a broadly defined comorbid anxiety disorder and important indices of clinical morbidity in bipolar disorder, including a greater number of depressive episodes, worse treatment outcomes, and elevated risk of attempting suicide. Anxiety symptoms and/or syndromes often precede the onset of bipolar disorder and may represent a clinical phenotype of increas...
Source: Current Psychiatry Reports - January 23, 2015 Category: Psychiatry Source Type: research

How Mindfulness Is Revolutionizing Mental Health Care
More than 350 million people globally suffer from depression, and 1 in 13 people around the world have been diagnosed with an anxiety disorder. Overall, the World Health Organization estimates that roughly 450 million people suffer from some form of mental or neurological disorder -- and that roughly one in four people will be affected at some point in their lives. These numbers are staggering. With the rise of mental illness and the increasingly pressing need for effective treatments, there's never been a more important moment for mindfulness -- the ability to cultivate a focused, non-judgmental awareness on the present...
Source: Science - The Huffington Post - January 23, 2015 Category: Science Source Type: news

Pseudoamniotic Band Syndrome after In Utero Intervention for Twin-to-Twin Transfusion Syndrome: Case Reports and Literature Review
We report 3 cases of PABS, 2 after fetoscopic laser photocoagulation and 1 after bipolar cord coagulation. Two cases were detected antenatally by ultrasound; out of the two, one underwent successful fetoscopic release of amniotic band, which is the first report in twin pregnancy to our knowledge. In our centre, the incidence of PABS was found to be 2%. There were 25 cases of PABS reported previously, of which 12 cases with clinical details were reviewed together with our 3 cases. The fetal limbs were involved in all 15 cases, leading to constriction or amputation. The umbilical cord was involved in 2 cases, resulting in fe...
Source: Fetal Diagnosis and Therapy - January 23, 2015 Category: Perinatology & Neonatology Source Type: research

Renaming schizophrenia to reduce stigma: comparison with the case of bipolar disorder - Ellison N, Mason O, Scior K.
This study compared the potentially destigmatising effects of renaming schizophrenia with the effects of renaming bipolar disorder by comparing the label 'schizophrenia' to 'i... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 23, 2015 Category: Global & Universal Tags: Commentary Source Type: news

Bipolar disorder subtypes in children and adolescents: demographic and clinical characteristics from an Australian sample - Hirneth SJ, Hazell PL, Hanstock TL, Lewin TJ.
BACKGROUND: Bipolar disorder (BD) phenomenology in children and adolescents remains contentious. The study investigated Australian children and adolescents with bipolar I disorder (BD-I), bipolar II disorder (BD-II), or BD not otherwise specified (BD-NOS).... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 23, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Childhood traumatic experiences of patients with bipolar disorder type I and type II - Janiri D, Sani G, Danese E, Simonetti A, Ambrosi E, Angeletti G, Erbuto D, Caltagirone C, Girardi P, Spalletta G.
BACKGROUND: Childhood trauma is an important environmental stressor associated with bipolar disorders (BD). It is still not clear if it is differently distributed between BD I and BD II. Therefore, the aim of this research was to investigate the distributi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 23, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double‐blind, placebo‐controlled trial
ConclusionThis study showed that pioglitazone could be a tolerable and effective adjunctive therapy for improving depressive symptoms in bipolar disorder without type 2 diabetes or metabolic syndrome. (Source: Depression and Anxiety)
Source: Depression and Anxiety - January 23, 2015 Category: Psychiatry Authors: Atefeh Zeinoddini, Maryam Sorayani, Elmira Hassanzadeh, Mohammad Arbabi, Mehdi Farokhnia, Samrand Salimi, Ali Ghaleiha, Shahin Akhondzadeh Tags: Research Article Source Type: research

Research Roundup
Teens who get sleep or anxiety medications more likely to abuse them Outcomes for ‘ultra‐high risk for psychosis' patients: Nonpsychotic disorders Olanzapine/fluoxetine superior to placebo in treating bipolar I depression in pediatric and adolescent patients Antidepressants for pediatric bipolar depression more likely than antipsychotics to cause manic switch (Source: The Brown University Child and Adolescent Psychopharmacology Update)
Source: The Brown University Child and Adolescent Psychopharmacology Update - January 23, 2015 Category: Psychiatry Tags: Research Roundup Source Type: research

Is There a Medical Test for Bipolar Disorder?
Medical tests for bipolar disorder may be in our future. Several avenues of research are promising and offer hope that soon diagnosis will be easier. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - January 23, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Benadryl / Diphenhydramine Side Effects
Catalogue of side effects for the medication Diphenhydramine / Benadryl. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - January 23, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder
This study demonstrated the potential interplay of three factors: BD offspring, anxiety symptoms and family dysfunction. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - January 23, 2015 Category: Psychiatry Source Type: research

Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder
Publication date: Available online 22 January 2015 Source:Journal of Psychiatric Research Author(s): Rosie May Walker , Joanna Rybka , Susan Maguire Anderson , Helen Scott Torrance , Ruth Boxall , Jessika Elizabeth Sussmann , David John Porteous , Andrew Mark McIntosh , Kathryn Louise Evans Bipolar disorder (BD) is a highly heritable psychiatric disorder characterised by recurrent episodes of mania and depression. Many studies have reported altered gene expression in BD, some of which may be attributable to the dysregulated expression of miRNAs. Studies carried out to date have largely studied medicated patients, so it i...
Source: Journal of Psychiatric Research - January 23, 2015 Category: Psychiatry Source Type: research

Bipolar resistive switching and charge transport in silicon oxide memristor
Publication date: April 2015 Source:Materials Science and Engineering: B, Volume 194 Author(s): Alexey N. Mikhaylov , Alexey I. Belov , Davud V. Guseinov , Dmitry S. Korolev , Ivan N. Antonov , Denis V. Efimovykh , Stanislav V. Tikhov , Alexander P. Kasatkin , Oleg N. Gorshkov , David I. Tetelbaum , Alexander I. Bobrov , Natalia V. Malekhonova , Dmitry A. Pavlov , Evgeny G. Gryaznov , Alexander P. Yatmanov Reproducible bipolar resistive switching has been studied in SiO x -based thin-film memristor structures deposited by magnetron sputtering technique on the TiN/Ti metalized SiO2/Si substrates. It is established that, a...
Source: Materials Science and Engineering: B - January 23, 2015 Category: Materials Science Source Type: research

Can Unipolar and Bipolar Pediatric Major Depression be Differentiated From Each Other? A Systematic Review of Cross-Sectional Studies Examining Differences in Unipolar and Bipolar Depression
While pediatric mania and depression can be distinguished from each other, differentiating between unipolar major depressive disorder (unipolar MDD) and bipolar major depression (bipolar MDD) poses unique clinical and therapeutic challenges. Our aim was to examine the current body of knowledge on whether unipolar MDD and bipolar MDD in youth could be distinguished from one another in terms of clinical features and correlates. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 23, 2015 Category: Neurology Authors: Mai Uchida, Giulia Serra, Lazaro Zayas, Tara Kenworthy, Stephen V. Faraone, Joseph Biederman Tags: Special review article Source Type: research

Age-dependent decreases of high energy phosphates in cerebral gray matter of patients with bipolar I disorder: A preliminary phosphorus-31 magnetic resonance spectroscopic imaging study
To identify abnormalities in high energy phosphate cerebral metabolism in euthymic bipolar disorder. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 23, 2015 Category: Neurology Authors: Jonathan A. Dudley, Jing-Huei Lee, Michelle Durling, Stephen M. Strakowski, James C. Eliassen Tags: Preliminary communication Source Type: research

A longitudinal proton magnetic resonance spectroscopy study investigating oxidative stress as A result of alcohol and tobacco use in youth with bipolar disorder
Alcohol and tobacco have been suggested to be “aggravating factors” for neuroprogression in bipolar disorder (BD), however the impact of these substances on the underlying neurobiology is limited. Oxidative stress is a key target for research into neuroprogression in BD and in accordance with this model, our previous cross-sectional studies have found that risky alcohol and tobacco use in BD is associated with increased oxidative stress, investigated via in vivo glutathione (GSH) measured by proton magnetic resonance spectroscopy (1H-MRS) in the anterior cingulate cortex (ACC). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 23, 2015 Category: Neurology Authors: Kate M. Chitty, Jim Lagopoulos, Ian B. Hickie, Daniel F. Hermens Tags: Research report Source Type: research

High-throughput RNA sequencing reveals the effects of 2,2¿,4,4¿ -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae
Conclusions: Our results suggest that high BDE47 concentrations disrupt the eye and bone development of zebrafish larvae based on both transcriptomic and morphological evidences. The abnormal visual perception may result in the alteration of dark adaption, which was probably responsible for the abnormal larval locomotion. Body curvature arose from enhanced bone resorption because of the intensive up-regulation of related genes. We also proposed the larval retina as a novel potential target tissue for BDE47 exposure. (Source: BMC Genomics)
Source: BMC Genomics - January 23, 2015 Category: Genetics & Stem Cells Authors: Ting XuJing ZhaoDaqiang YinQingshun ZhaoBingzhi Dong Source Type: research

Homogeneous Magnetic Resonance Imaging of Brain Abnormalities in Bipolar Spectrum Disorders Comorbid with Wilson's Disease
To determine if brain damage in Wilson’s Disease (WD) is different in comorbid Bipolar Spectrum Disorders (BDs), comorbid Major Depressive Disorder (MDD) or without any mood disorders. (Source: General Hospital Psychiatry)
Source: General Hospital Psychiatry - January 23, 2015 Category: Psychiatry Authors: Mauro Giovanni Carta, Luca Saba, Maria Francesca Moro, Enrico Demelia, Orazio Sorbello, Mirra Pintus, Elisa Pintus, Tatevik Simavorian, Hagop Akiskal, Luigi Demelia Tags: Psychiatric-Medical Comorbidity Source Type: research

Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder
In this study we investigated whether patients with schizophrenia, bipolar disorder, or major depressive disorder have abnormalities in PUFA levels in the prefrontal cortex [Brodmann area (BA) 8]. (Source: Psychiatry Research)
Source: Psychiatry Research - January 23, 2015 Category: Psychiatry Authors: Kei Hamazaki, Motoko Maekawa, Tomoko Toyota, Brian Dean, Tomohito Hamazaki, Takeo Yoshikawa Source Type: research

Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study.
Conclusions: This study identified three genetic components comprising multiple genes mediating ERP subcomponent abnormalities in schizophrenia and psychotic bipolar disorder. The data suggest a possible polygenic structure comprising genes influencing key neurodevelopmental processes, neural circuitry, and brain function mediating biological pathways plausibly associated with psychosis. PMID: 25615564 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - January 23, 2015 Category: Psychiatry Authors: Narayanan B, Ethridge LE, O'Neil K, Dunn S, Mathew I, Tandon N, Calhoun VD, Ruaño G, Kocherla M, Windemuth A, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD Tags: Am J Psychiatry Source Type: research

Diffusion-weighted imaging of the liver: comparison of image quality between monopolar and bipolar acquisition schemes at 3T
Conclusion In comparison with past studies performed at 1.5T, when using a modern 3T system, we observed improved image quality of liver DWI using a monopolar, rather than a bipolar, acquisition scheme, largely attributed to higher eSNR. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 22, 2015 Category: Radiology Source Type: research

Association between longitudinal changes in prefrontal hemodynamic responses and social adaptation in patients with Bipolar Disorder and Major Depressive Disorder
This study examined the region-specific functional abnormality associated with bipolar disorder (BD) and major depressive disorder (MDD), and the association between particular longitudinal changes in regional activation and social adaptation. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 22, 2015 Category: Neurology Authors: Toshiyuki Ohtani, Yukika Nishimura, Katsuyoshi Takahashi, Reina Ikeda-Sugita, Naohiro Okada, Yuji Okazaki Tags: Research report Source Type: research

Course and outcome following a first episode of mania: Four-year prospective data from the systematic treatment Optimization Program (STOP-EM)
We present 4-year outcomes from the STOP-EM FEM cohort. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 22, 2015 Category: Neurology Authors: Andréanne Gignac, Alexander McGirr, Raymond W. Lam, Lakshmi N. Yatham Tags: Research report Source Type: research

Rapid cycling as a feature of bipolar disorder and comorbid migraine
Previous research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 22, 2015 Category: Neurology Authors: K. Gordon-Smith, L. Forty, C. Chan, S. Knott, I. Jones, N. Craddock, L.A. Jones Tags: Brief report Source Type: research

Effectiviness of Individual Psychoeducation on Recurrence in Bipolar Disorder; A Controlled Study
This research was conducted as an controlled experimental study which aimed to determine the effectiveness of individual psychoeducation program on recurrence rate during 1year follow up period. The study included eighty-two patients who had been diagnosed with bipolar disorder. There were no hospitalizations in intervention group, while 7.3% of control patients experienced hospitalizations; recurrence rates were 18.9% in the intervention group patients and 34.1% in the control group patients, but statistical significant difference between the groups was not found. (Source: Archives of Psychiatric Nursing)
Source: Archives of Psychiatric Nursing - January 22, 2015 Category: Nursing Authors: Funda Gumus, Sevim Buzlu, Sibel Cakir Source Type: research

Maintaining mood stability in bipolar disorder: a clinical perspective on pharmacotherapy
Introduction Bipolar disorder is defined by its poles, elevated mood or irritability characterises mania, and marked low mood and lack of energy typifies depression. Treatment of these acute states is necessary for the patient's well-being but the major management challenge lies in reducing the frequency and severity of relapses and recurrences, and maintaining healthy mood. Typically, patients with bipolar disorder experience a recurrence every 17–30 months and have multiple episodes over the course of the illness.1 Successful management of this chronic, recurrent illness ultimately depends on maintaining long-...
Source: Evidence-Based Mental Health - January 22, 2015 Category: Psychiatry & Psychology Authors: Malhi, G. S., McAulay, C., Das, P., Fritz, K. Tags: Editor's choice, Bipolar disorder, Depressive disorder Clinical review Source Type: research

Early identification of recurrent mood disorders in youth: the importance of a developmental approach
Introduction Adolescence is an important developmental period characterised by accelerated biological, psychological and sociological development. Adolescence is also the high-risk period for onset of major psychiatric disorders that persist into adulthood. In particular, mood disorders in youth account for a substantial proportion of disability and premature death in those aged 10–24 years.1 In contrast to prepubertal mood disorders, adolescent mood disorders recur or persist lifelong and are associated with a high estimated heritability.2 Suicide is the second leading cause of death in youth in Canada and the ...
Source: Evidence-Based Mental Health - January 22, 2015 Category: Psychiatry & Psychology Authors: Duffy, A. Tags: Editor's choice, Neurology, Bipolar disorder, Suicide (psychiatry) Perspective Source Type: research

Mixed associations observed between advanced paternal age and psychiatric morbidity in offspring
What is already known on this topic? Advanced maternal age has long been acknowledged as a risk factor for genetic disorders such as Down's syndrome. Owing to the large number of cell divisions that occur during spermatogenesis, we can speculate that advanced paternal age (APA) can contribute to an increased number of de novo mutations.1 Autosomal dominant diseases such as achondroplasia and multiple endocrine neoplasia syndrome are strongly associated with APA. However, the association between APA and complex disorders such as cancer and psychopathology is less clear. What does this paper add? This is the largest populati...
Source: Evidence-Based Mental Health - January 22, 2015 Category: Psychiatry & Psychology Authors: Ramasamy, R., Lipshultz, L. I. Tags: Epidemiologic studies, Neurology, Autism, Attention-deficit hyperactivity disorder, Pervasive developmental disorder, Substance dependence, Bipolar disorder, Suicide (psychiatry), Epidemiology, Screening (epidemiology), Competing interests (ethics) Caus Source Type: research

Women on valproate drugs need clear warnings about risk to fetuses.
Abstract Women of childbearing age who have bipolar disorder or epilepsy need to be warned that medication for the conditions can damage unborn children, says the Medicines and Healthcare products Regulatory Agency (MHRA). PMID: 25608716 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - January 22, 2015 Category: Nursing Authors: Gillen S Tags: Nurs Stand Source Type: research

Epidemiological and clinical aspects will guide the neuroimaging research in bipolar disorder.
Authors: Houenou J, Perlini C, Brambilla P Abstract Although neurobiological mechanisms of bipolar disorder (BD) are still unclear, neural models of the disease have recently been conceptualised thanks to neuroimaging. Indeed, magnetic resonance imaging (MRI) studies investigating structural and functional connectivity between different areas of the brain suggest an altered prefrontal-limbic coupling leading to disrupted emotional processing in BD, including uncinate fasciculus, amygdala, parahippocampal cortex, cingulate cortex as well corpus callosum. Specifically, these models assume an altered prefrontal contro...
Source: Epidemiology and Psychiatric Sciences - January 21, 2015 Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research

Bipolar medications and weight gain
Some bipolar medications can cause weight gain. Here's what you need to know. (Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - January 21, 2015 Category: Consumer Health News Source Type: news

Intermediate-Term Results of Partial Plantar Fascia Release with Microtenotomy Using Bipolar Radiofrequency Microtenotomy
Publication date: Available online 21 January 2015 Source:The Journal of Foot and Ankle Surgery Author(s): Douglas E. Lucas , Scott R. Ekroth , Christopher F. Hyer Plantar fasciitis is a common condition, with most patients treated successfully with nonoperative management. Recalcitrant disease has been managed with surgical procedures that vary in design and associated morbidity. The present study sought to determine the intermediate-term results of percutaneous bipolar radiofrequency microtenotomy in recalcitrant plantar fasciitis. The patient medical records were reviewed, and data were gathered for all the patients w...
Source: The Journal of Foot and Ankle Surgery - January 21, 2015 Category: Orthopaedics Source Type: research

The trajectory of neuropsychological dysfunctions in bipolar disorders: A critical examination of a hypothesis
The hypothesis of a progressive nature of neuropsychological deficits in bipolar disorders is often accepted as an axiom by many clinicians and researchers in the field. However, contradictory pieces of data and a number of methodological concerns put it under debate. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - January 21, 2015 Category: Neurology Authors: Sergio A. Strejilevich, Cecilia Samamé, Diego J. Martino Tags: Special review article Source Type: research

Intermediate-Term Results of Partial Plantar Fascia Release with Microtenotomy Using Bipolar Radiofrequency Microtenotomy
Plantar fasciitis is a common condition, with most patients treated successfully with nonoperative management. Recalcitrant disease has been managed with surgical procedures that vary in design and associated morbidity. The present study sought to determine the intermediate-term results of percutaneous bipolar radiofrequency microtenotomy in recalcitrant plantar fasciitis. The patient medical records were reviewed, and data were gathered for all the patients who met the inclusion criteria. The foot function index and visual analog scale (VAS) pain scale questionnaires were mailed to the 111 patients. (Source: Journal of Fo...
Source: Journal of Foot and Ankle Surgery - January 21, 2015 Category: Orthopaedics Authors: Douglas E. Lucas, Scott R. Ekroth, Christopher F. Hyer Tags: Original Research Source Type: research

Effects of lithium on growth, maturation, reproduction and gene expression in the nematode Caenorhabditis elegans
This study was conducted to clarify the potential biological effects of LiCl and Li2CO3 on a nematode, Caenorhabditis elegans as a model system for evaluating soil contaminated with Li. Exposure of C. elegans to LiCl and Li2CO3 decreased growth/maturation and reproduction. The lowest observed effect concentrations for growth, maturation and reproduction were 1250, 313 and 10 000 µm, respectively, for LiCl and 750, 750 and 3000 µm, respectively, for Li2CO3. We also investigated the physiological function of LiCl and LiCO3 in C. elegans using DNA microarray analysis as an eco‐toxicogenomic approach. Among approximate...
Source: Journal of Applied Toxicology - January 21, 2015 Category: Toxicology Authors: Ayako Inokuchi, Ryoko Yamamoto, Fumiyo Morita, Shota Takumi, Hiromi Matsusaki, Hiroshi Ishibashi, Nobuaki Tominaga, Koji Arizono Tags: Research Article Source Type: research

Co-morbidity of Bipolar Disorder and Borderline Personality Disorder: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions
This study examines the prevalence and correlates of BPD in BD (I and II) in a longitudinal population-based survey. (Source: Comprehensive Psychiatry)
Source: Comprehensive Psychiatry - January 21, 2015 Category: Psychiatry Authors: Joanna McDermid, Jitender Sareen, Renée El-Gabalawy, Jina Pagura, Rae Spiwak, Murray W. Enns Source Type: research

Behavioral health acutely needs EHRs
A show of hands: Who believes depression or bipolar disorder have no impact on the severity and treatment of a patient’s diabetes and COPD? It’s an idea no practicing physician would support. Yet time and again, we act as though mental illness and care can be kept separate from physical ailments. read more (Source: Healthcare IT News)
Source: Healthcare IT News - January 20, 2015 Category: Information Technology Authors: Edmund Billings, MD Tags: Meaningful Use Electronic Health Records Quality and Safety Source Type: news

Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study
w & F Schlagenhauf (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - January 20, 2015 Category: Psychiatry Authors: M BauerS BermanT StammM PlotkinM AdliM PilhatschE D LondonG S HellemannP C WhybrowF Schlagenhauf Source Type: research