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Cardiovascular risk factors among bipolar disorder patients admitted to an inpatient unit of a tertiary care hospital in India.
CONCLUSIONS: Findings of the present study suggest the presence of cardiovascular risk factors and higher rate of metabolic syndrome in patients with bipolar disorder. Considering this fact, there is an urgent need for routine screening for cardiovascular risk factors in these patients. Mental health professionals should be aware of these risks; there is need to develop preventive strategies to reduce the cardiovascular risk in this population. PMID: 25042952 [PubMed - in process] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - July 22, 2014 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

UCLA faculty contribute to international study on the biology behind schizophrenia
UCLA researchers were part of a multinational effort that has identified more than 100 locations in the human genome associated with the risk of developing schizophrenia. The study, the largest genomic study published on any psychiatric disorder to date, provides important new insights about the biological causes of schizophrenia, and it could lead to new approaches to treatment. The report was published in the July 22 online edition of the journal Nature. "As recently as five years ago, we still lacked proof that mental disorders had a genetic basis," said Dr. Nelson Freimer, a UCLA professor of psychiatry and director of...
Source: UCLA Newsroom: Health Sciences - July 22, 2014 Category: Universities & Medical Training Source Type: news

All the world’s a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective
All the world’s a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective Molecular Psychiatry advance online publication, July 22 2014. doi:10.1038/mp.2014.71 Authors: E Frank, V L Nimgaonkar, M L Phillips & D J Kupfer (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - July 22, 2014 Category: Psychiatry Authors: E FrankV L NimgaonkarM L PhillipsD J Kupfer Source Type: research

Endogenous calcium buffering at photoreceptor synaptic terminals in salamander retina
Abstract Calcium operates by several mechanisms to regulate glutamate release at rod and cone synaptic terminals. In addition to serving as the exocytotic trigger, Ca2+ accelerates replenishment of vesicles in cones and triggers Ca2+‐induced Ca2+ release (CICR) in rods. Ca2+ thereby amplifies sustained exocytosis, enabling photoreceptor synapses to encode constant and changing light. A complete picture of the role of Ca2+ in regulating synaptic transmission requires an understanding of the endogenous Ca2+ handling mechanisms at the synapse. We therefore used the “added buffer” approach to measure the endogenous Ca2+ ...
Source: Synapse - July 22, 2014 Category: Neurology Authors: Matthew J. Van Hook, Wallace B. Thoreson Tags: Research Article Source Type: research

Combined treatment: impact of optimal psychotherapy and medication in bipolar disorder
ConclusionsCombined pharmacological and adjunctive psychosocial treatments appeared to provide an improved course of illness compared to the results of previous studies. Efforts to further improve the course of illness beyond that provided by current optimal treatment regimens will require a substantial focus on both subsyndromal and syndromal depressive symptoms. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 21, 2014 Category: Psychiatry Authors: Sagar V Parikh, Lisa D Hawke, Vytas Velyvis, Ari Zaretsky, Serge Beaulieu, Irene Patelis‐Siotis, Glenda MacQueen, L Trevor Young, Lakshmi N Yatham, Pablo Cervantes Tags: Original Article Source Type: research

Behavioral approach system sensitivity and risk taking interact to predict left-frontal EEG asymmetry.
Abstract The Behavioral Approach System (BAS) hypersensitivity theory of bipolar disorder (BD; Alloy & Abramson, 2010; Depue & Iacono, 1989) suggests that hyperreactivity in the BAS results in the extreme fluctuations of mood characteristic of BD. In addition to risk conferred by BAS hypersensitivity, cognitive and personality variables may play a role in determining risk. We evaluated relationships among BAS sensitivity, risk taking, and an electrophysiological correlate of approach motivation, relative left-frontal electroencephalography (EEG) asymmetry. BAS sensitivity moderated the relationship between ...
Source: Behavior Therapy - July 20, 2014 Category: Psychiatry & Psychology Authors: Black CL, Goldstein KE, LaBelle DR, Brown CW, Harmon-Jones E, Abramson LY, Alloy LB Tags: Behav Ther Source Type: research

How to Recognize a Manic or Hypomanic Episode
Here's what you need to watch for that may signal someone you know is starting into or having a bipolar manic or hypomanic episode. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 20, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

When You Shouldn’t Drink Grapefruit Juice...
Drinking grapefruit juice can cause serious problems with your medications. Here's why, and a partial list of drugs that can be affected. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 20, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

3 Red Flags That Could Signal Bipolar Disorder
Learn how to tell when your experiences are normal and when they’ve pushed into the extremes of depression or mania associated with bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 20, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Experts urge new discipline combining benefits of neuroscience, psychology treatments
For some conditions, such as bipolar disorder, psychological treatments are not effective or are in their infancy. A 'culture gap' between neuroscientists and clinical scientists is hindering mental health treatment, say the life scientists, who call on scientists from both disciplines to work together to advance the understanding and treatment of psychological disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 18, 2014 Category: Science Source Type: news

Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.
Authors: Nickl-Jockschat T, Stöcker T, Krug A, Markov V, Maximov II, Huang R, Schneider F, Habel U, Eickhoff SB, Zerres K, Nöthen MM, Rietschel M, Jon Shah N, Treutlein J, Kircher T Abstract G72 (syn. DAOA, D-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. Diffusion tensor imaging studies hint at changes in fiber tract integrity in both disorders. We aimed to investigate whether a G72 susceptibility haplotype causes changes in fiber tract integrity in young healthy subjects. We compared fractional anisotropy in 47 subjects that were either homozygous for the M23...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 18, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Experts urge new discipline combining benefits of neuroscience and psychology treatments
(University of California - Los Angeles) For some conditions, such as bipolar disorder, psychological treatments are not effective or are in their infancy. A 'culture gap' between neuroscientists and clinical scientists is hindering mental health treatment, say the life scientists, who call on scientists from both disciplines to work together to advance the understanding and treatment of psychological disorders. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2014 Category: Global & Universal Source Type: news

Combination of Omega-3 Fatty Acids, Lithium, and Aripiprazole Reduces Oxidative Stress in Brain of Mice with Mania.
Abstract Manic episode in bipolar disorder (BD) was evaluated in the present study with supplementation of omega-3 fatty acids in combination with aripiprazole and lithium on methylphenidate (MPD)-induced manic mice model. Administration of MPD 5 mg/kg bw intraperitoneally (i.p.) caused increase in oxidative stress in mice brain. To retract this effect, supplementation of omega-3 fatty acids 1.5 ml/kg (p.o.), aripiprazole 1.5 mg/kg bw (i.p.), and lithium 50 mg/kg bw (p.o) were given to mice. Omega-3 fatty acids alone and in combination with aripiprazole- and lithium-treated groups significantly reduced the leve...
Source: Biological Trace Element Research - July 18, 2014 Category: Biology Authors: Arunagiri P, Rajeshwaran K, Shanthakumar J, Tamilselvan T, Balamurugan E Tags: Biol Trace Elem Res Source Type: research

A network meta-analysis on comparative efficacy and all-cause discontinuation of antimanic treatments in acute bipolar mania.
CONCLUSIONS: Hierarchical rank ordering by comparative efficacy and risk of all-cause discontinuations should help to guide antimanic treatment choices by clinicians, healthcare policy makers, and guideline developers. PMID: 25036226 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 18, 2014 Category: Psychiatry Authors: Yildiz A, Nikodem M, Vieta E, Correll CU, Baldessarini RJ Tags: Psychol Med Source Type: research

Retinal bipolar cells: elementary building blocks of vision
Nature Reviews Neuroscience 15, 507 (2014). doi:10.1038/nrn3783 Authors: Thomas Euler, Silke Haverkamp, Timm Schubert & Tom Baden Retinal bipolar cells are the first 'projection neurons' of the vertebrate visual system — all of the information needed for vision is relayed by this intraretinal connection. Each of the at least 13 distinct types of bipolar cells systematically transforms the photoreceptor input in a (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - July 18, 2014 Category: Neuroscience Authors: Thomas EulerSilke HaverkampTimm SchubertTom Baden Tags: Review Source Type: research

5 Requirements to Qualify for Disability
The Social Security Administration has a formula for determining if an individual is considered disabled. There are five basic steps that must be met in order to qualify for disability. Here is an outline of these steps. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 18, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Pdoc
is a term derived from the compression of two words. More ... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 18, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Anxiety Attacks Happen in Bipolar Disorder
Anxiety attacks or panic attacks are common in people who have bipolar disorder. Many with bipolar disorder also suffer from one or more anxiety or panic disorders. Here is an overview of the various types of anxiety attacks and panic disorders that may affect those who have bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 18, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What Is Stevens-Johnson Syndrome and What...
Stevens-Johnson Syndrome is a severe inflammatory eruption of the skin and mucous membranes that may occur as a result of treatment with Lamictal (lamotrigine). More ... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 18, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity.
This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. We measured plasma PON1 activity and serum HDL cholesterol and determined PON1 Q192R genotypes through functional analysis in 335 subjects, consisting of 97 with and 238 without MetS. The severity of nicotine dependence was measured using the Fagerström Nicotine Dependence Scale. Results PON1 Q192R functional genotypes and PON1 Q192R genotypes by smoking i...
Source: Redox Report : communications in free radical research - July 18, 2014 Category: Biochemistry Authors: Bortolasci CC, Vargas HO, Souza-Nogueira A, Gastaldello Moreira E, Vargas Nunes SO, Berk M, Dodd S, Barbosa DS, Maes M Tags: Redox Rep Source Type: research

Need exists for genetic predictors of lithium response
What is already known on this topic? Patients with bipolar disorder respond differentially to lithium; some predictors of good response, including a family history of such, are known, though their predictive power is modest.1 As other medications are available for this illness, it would be valuable to identify biomarkers, including genetic ones, with greater ability to accurately forecast which patients will respond to lithium and which will not. One prior study examined genetic biomarkers of response and found no significant results.2 What does this paper add? Genetic variation in one gene almost entirely determined wheth...
Source: Evidence-Based Mental Health - July 18, 2014 Category: Psychiatry & Psychology Authors: Potash, J. B., Schulze, T. G. Tags: Drugs: psychiatry, Bipolar disorder, Competing interests (ethics) Causes and risk factors Source Type: research

One-third of children of parents with severe mental illness are at risk of developing severe mental illness
This study provides the most current systematic evidence on the level of risk for children developing the same type of mental illness, or other types of mental illness, when their parents have schizophrenia, bipolar disorder or major depression. The results (32% risk of serious mental illness, 55% risk of any mental illness) extend the existing knowledge on this group of children's vulnerability for developing mental illness by adulthood, revealing a level of risk higher than previously identified.... (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - July 18, 2014 Category: Psychiatry & Psychology Authors: Foster, K. Tags: General practice / family medicine, Bipolar disorder, Depressive disorder, Schizophrenia spectrum, Competing interests (ethics) Causes and risk factors Source Type: research

Experts urge new discipline combining benefits of neuroscience and psychology treatments
When a patient talks with a psychological therapist, what changes occur in the patient's brain that relieve mental disorders? UCLA psychology professor Michelle Craske says the honest answer is that we don't know. But, according to Craske and two colleagues, we need to find out. Mental health disorders — such as depression, schizophrenia, post-traumatic stress disorder, obsessive–compulsive disorder and eating disorders — affect 1 in 4 people worldwide. Psychological treatments "hold the strongest evidence base for addressing many such conditions," but they need improvement, according to a study by Craske, Cambridge ...
Source: UCLA Newsroom: Health Sciences - July 17, 2014 Category: Universities & Medical Training Source Type: news

Assessing and staging bipolar disorder.
Authors: Agius M, Rogers J, Bongards E, O'Connor S, Verdolini N, Elisei S PMID: 25029698 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - July 17, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

The Use of Simulation to Teach Suicide Risk Assessment to Health Profession Trainees-Rationale, Methodology, and a Proof of Concept Demonstration with a Virtual Patient.
CONCLUSIONS: Our study provides proof of concept that both VP and video module approaches are feasible for teaching students to assess suicide risk, and we present evidence about the role of active learning to improve communication skills. Depending on the learning context, interviewing a VP or observation of a videotaped interview can enhance the students' suicide risk assessment proficiency in an interview with a standardized patient. An interactive VP is a plausible modality to deliver basic concepts of suicide risk assessment to medical students, can facilitate individual preferences by providing easy access and portab...
Source: The Journal of American Association of Directors of Psychiatric Residency Training - July 17, 2014 Category: Psychiatry Tags: Acad Psychiatry Source Type: research

Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning
Abstract Glutamatergic signaling through N‐methyl‐D‐aspartate receptors (NMDARs) is important for neuronal development and plasticity and is often dysregulated in psychiatric disorders. Mice mutant for the transcription factor Sp4 have reduced levels of NMDAR subunit 1 (NR1) protein, but not mRNA, and exhibit behavioral and memory deficits (Zhou et al., 2010). In developing cerebellar granule neurons (CGNs), Sp4 controls dendrite patterning (Ramos et al., 2007). Sp4 target genes that regulate dendrite pruning or NR1 levels are not known. Here we report that Sp4 activates transcription of Nervous Wreck 2 (Nwk2; also k...
Source: Journal of Neurobiology - July 17, 2014 Category: Neurology Authors: Xinxin Sun, Raquel Pinacho, Gregory Saia, Diana Punko, J.Javier Meana, Belén Ramos, Grace Gill Tags: Research Article Source Type: research

Sleep architecture and cognitive changes in olanzapine-treated patients with depression: A double blind randomized placebo controlled trial
Conclusions: Olanzapine augmentation treatment generally did not improve SWS but did improve sleep continuity and depression. Olanzapine may be one of few medications that improve sleep continuity, thus directly targeting symptoms of depression.Trial registration: ClinicalTrials.gov, NCT00520507. (Source: BMC Psychiatry - Latest articles)
Source: BMC Psychiatry - Latest articles - July 17, 2014 Category: Psychiatry Authors: Lauren LazowskiBen TownsendEmily HawkenRuzica JokicRegina du ToitRoumen Milev Source Type: research

Do You Have Manic Episodes? Take This Bipolar...
This quiz is an informal checklist for you to use to determine whether you're likely to have experienced, or are currently in a state of, bipolar mania. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 16, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Antifungal Drugs and Psychiatric Medications
If you have a fungus problem such as athlete's foot, a vaginal infection, or jock itch, you'll probably be using an antifungal agent to treat it. There are also prescription drugs taken orally to treat conditions like thrush and other yeast infections. It's important to know that some antidepressants and antipsychotics in particular can react badly to medications that treat fungus. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 16, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

6 Red Flag Signs You Might Be Depressed
Depression is considered one of the primary symptoms of bipolar disorder. However, it is actually a set of symptoms characteristic of one aspect of bipolar disorder. An episode of depression, as it relates to bipolar disorder, is the downswing in a mood cycle. An episode of depression is very debilitating often leaving the sufferer completely dysfunctional. It is an extreme emotional state that impairs daily living so it is important to be familiar with the warning signs of depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 16, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Impulsivity predicts time to reach euthymia in adults with bipolar disorder
ConclusionsBetter trait impulse control may be associated with better treatment responsiveness among adults with bipolar disorder. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 16, 2014 Category: Psychiatry Authors: Erica L Dawson, Paula K Shear, Steven R Howe, Caleb M Adler, Melissa P DelBello, David E Fleck, Stephen M Strakowski Tags: Original Article Source Type: research

Effective connectivity of the posterior cingulate and medial prefrontal cortices relates to working memory impairment in schizophrenic and bipolar patients
(Source: Schizophrenia Research)
Source: Schizophrenia Research - July 16, 2014 Category: Psychiatry Authors: Guowei Wu, Yunxia Wang, Tumbwene E. Mwansisya, Weidan Pu, Huiran Zhang, Chang Liu, Qing Yang, Eric Y.H. Chen, Zhimin Xue, Zhening Liu, Baoci Shan Source Type: research

Is There a Link Between OCD and Bipolar Disorder?
Clinical research suggests that OCD and bipolar disorder co-occur with each other at a higher rate than would be expected by chance. Importantly, the comorbidity between OCD and bipolar disorder can affect symptoms and treatment. Learn more about the association between OCD and bipolar disorder. (Source: About.com Obsessive Compulsive Disorder)
Source: About.com Obsessive Compulsive Disorder - July 16, 2014 Category: Psychiatry Tags: health Source Type: news

[Services on early recognition of psychoses and bipolar disorders in Germany : Inventory survey study.]
CONCLUSION: Despite widespread interest and the increasingly recognized importance of early recognition and intervention services in psychiatry, there is currently no nationwide coverage with early recognition services for severe mental disorders in Germany. Public relations and information activities are not (yet) sufficiently provided to reach affected persons and their environment. Common standards are (still) missing and interdisciplinary models are sparse. To correct these shortcomings, amongst other factors, acquisition of sufficient funding for such services is required. PMID: 25022895 [PubMed - as supplied by p...
Source: Der Nervenarzt - July 16, 2014 Category: Neurology Authors: Leopold K, Nikolaides A, Bauer M, Bechdolf A, Correll CU, Jessen F, Juckel G, Karow A, Lambert M, Klosterkötter J, Ruhrmann S, Pfeiffer S, Pfennig A Tags: Nervenarzt Source Type: research

Spatial Resolution of Defibrillator Electrograms to Detect Distinct Exit Sites of Scar‐Related Ventricular Tachycardia
ConclusionsAnalysis of IEGM morphology with pacing around the edge of the scar is unable to distinguish distinct VT exit sites spaced <2 cm apart, with an average spatial resolution of 5 cm. Given the wide range of values observed, detailed pace mapping over a perimeter of 10–15 cm along the scar edge appears crucial to define the boundaries of a linear ablation strategy to target the VT exit site based on IEGM pace match alone. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - July 15, 2014 Category: Cardiology Authors: PASQUALE SANTANGELI, OSCAR ALCALDE, ERICA S. ZADO, DAVID J. CALLANS, FRANCIS E. MARCHLINSKI Tags: ORIGINAL ARTICLE Source Type: research

The Developmental Basis of Epigenetic Regulation of HTR2A and Psychiatric Outcomes
The objective of this perspective article is to address the medical implications of HTR2A epigenetic regulation, which has been associated with both infant neurobehavioral outcomes and adult mental health. Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. Epigenetic regulation of HTR2A has been studied in several different types of tissues, including the placenta. The placenta is an impo...
Source: Journal of Cellular Biochemistry - July 15, 2014 Category: Biochemistry Authors: Alison G. Paquette, Carmen J. Marsit Tags: Prospects Source Type: research

Maurice Benard - Actor
Maurice Benard, who plays Sonny Corinthos on General Hospital, has spoken openly about having bipolar disorder for many years and acts as a spokesman for two major mental health organizations. Breakdowns, medication compliance and anxiety attacks are just some of the things he has taken into the public eye. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 14, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Negative psychological sense of community: development of a measure and theoretical implications
Psychological sense of community (PSOC) has been a focus of extensive research investigation. However, despite the emphasis on the positive aspects of PSOC, scholars have paid relatively little attention on its negative aspects. The present work assumes PSOC to be a bipolar construct (Brodsky, ), introduces negative psychological sense of community (NPSOC) as a centrifugal force that drives individuals away from the community, and reports the development of the NPSOC scale. Community residents (N = 612) were sampled and surveyed to examine the statistical validity and the psychometric properties of the NPSOC scale. Confirm...
Source: Journal of Community Psychology - July 14, 2014 Category: Psychiatry & Psychology Authors: Terri Mannarini, Alessia Rochira, Cosimo Talò Tags: ARTICLE Source Type: research

Time‐dependent tree‐structured survival analysis with unbiased variable selection through permutation tests
We present a method that uses unbiased significance levels from newly proposed permutation tests to select the time‐dependent or baseline covariate with the strongest relationship with the survival outcome. The specific splitting value is identified using only the selected covariate. Simulation results show that the proposed time‐dependent TSSA method produces tree models of equal or greater accuracy as compared to baseline TSSA models, even with high censoring rates and large within‐subject variability in the time‐dependent covariate. To illustrate, the proposed method is applied to data from a cohort of bipolar y...
Source: Statistics in Medicine - July 14, 2014 Category: Statistics Authors: M. L. Wallace Tags: Research Article Source Type: research

DSM‐5‐defined ‘mixed features’ and Benazzi's mixed depression: Which is practically useful to discriminate bipolar disorder from unipolar depression in patients with depression?
ConclusionsDSM‐5‐defined mixed features were too restrictive to discriminate BP from MDD in patients with depression compared with Benazzi's definition. To confirm this finding, studies that include patients with BP‐I and using tools to assess manic/hypomanic symptoms during MDE are necessary. (Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - July 14, 2014 Category: Neuroscience Authors: Minoru Takeshima, Takashi Oka Tags: Regular Article Source Type: research

Recoupling Mitotic Stress to Programmed Cell Death
Non–small cell lung cancer (NSCLC) is notorious for its paltry responses to first-line therapeutic regimens. In contrast to acquired chemoresistance, little is known about the molecular underpinnings of the intrinsic resistance of chemo-naïve NSCLC. Here we report that intrinsic resistance to paclitaxel in NSCLC occurs at a cell-autonomous level because of the uncoupling of mitotic defects from apoptosis. To identify components that permit escape from mitotic stress–induced death, we used a genome-wide RNAi-based strategy, which combines a high-throughput toxicity screen with a live-cell imaging platform to measure mi...
Source: Cancer Research - July 14, 2014 Category: Cancer & Oncology Authors: Sinnott, R., Winters, L., Larson, B., Mytsa, D., Taus, P., Cappell, K. M., Whitehurst, A. W. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

Outcomes of simple saline-coupled bipolar electrocautery for hepatic resection.
CONCLUSION: Simple saline-coupled BIP should be considered a safe and reliable technique for liver resection to decrease intraoperative hemorrhage and postoperative complications. PMID: 25024620 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2014 Category: Gastroenterology Authors: Guo JY, Li DW, Liao R, Huang P, Kong XB, Wang JM, Wang HL, Luo SQ, Yan X, Du CY Tags: World J Gastroenterol Source Type: research

[Accidental finding of a cri du chat syndrome in an adult patient by means of array-CGH].
CONCLUSIONS. The multiple gene deletions confirmed the CDCS diagnosis, being responsible for the patient phenotype. It has been showed up the importance of using the correct diagnosis techniques (array-CGH, peripheral blood karyotype) as well as their appropriate choice. PMID: 25005318 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - July 13, 2014 Category: Neurology Authors: Ferreiros-Martinez R, Lopez-Manzanares L, Alonso-Cerezo C Tags: Rev Neurol Source Type: research

Association of testosterone levels and future suicide attempts in females with bipolar disorder - Sher L, Grunebaum MF, Sullivan GM, Burke AK, Cooper TB, Mann JJ, Oquendo MA.
BACKGROUND: Considerable evidence suggests that testosterone may play a role in the pathophysiology of mood disorders in females. This is the first prospective study to examine whether blood testosterone levels predict suicide attempts in females with bipo... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 13, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Starting lithium prophylaxis early v. late in bipolar disorder.
CONCLUSIONS: Starting lithium treatment early following first psychiatric contact or a single manic/mixed episode is associated with increased probability of lithium response. PMID: 25012681 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - July 12, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Do Comedians Possess Bipolar Traits?
read more (Source: Psychology Today Personality Center)
Source: Psychology Today Personality Center - July 12, 2014 Category: Psychiatry & Psychology Authors: Gil Greengross, Ph.D. Tags: Creativity Evolutionary Psychology Intelligence Personality Psychiatry bipolar disorder humor stand-up comedy Source Type: news

Subjective and Physiological Emotional Response in Euthymic Bipolar Patients: A Pilot Study
(Source: Psychiatry Research)
Source: Psychiatry Research - July 12, 2014 Category: Psychiatry Authors: Mathieu Lemaire, Nadia Hernandez, Frédérique Bonnet-Brilhault, Joëlle Martineau, Wissam El-Hage Source Type: research

Should You Take Symbyax for Your Bipolar...
Symbyax is a combination of olanzapine, the active ingredient in Zyprexa, and fluoxetine, the active ingredient in Prozac. It is the first medication approved by the FDA the treatment of the depressive phase of bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 12, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

What Is a Mixed Episode in Bipolar Disorder?
Using the strict definition, a mixed episode can only be experienced by someone with Bipolar I disorder. However, many researchers - and many patients - agree that there are several types of mixed episodes that can be experienced by just about anyone with manic depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 12, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

The effect of cognitive functioning on treatment attendance and adherence in comorbid bipolar disorder and cocaine dependence
(Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - July 12, 2014 Category: Addiction Authors: Colleen S. Fagan, Thomas J. Carmody, Shawn M. McClintock, Alina Suris, Alyson Nakamura, Haekyung Jeon-Slaughter, Alexander Lo, E. Sherwood Brown Source Type: research