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ICYMI: The Perils Of A Bad Mug Shot And Why STD-Testing Condoms Might Not Be That Awesome
ICYMI Health features what we're reading this week. This week, first-person essays by individuals affected by stigmatized diseases and disorders caught our eye. We spent time with the account of a writer struggling with chronic kidney damage from the lithium she has used to manage her bipolar disorder for 20 years. We had our hearts broken reading about a sister who had to pick up the pieces after her talented sibling died of a drug overdose. And we tuned in when a handful of a celebrities described how it feels to have a panic attack -- a good reminder that anxiety can affect anyone, regardless of life circumstances. R...
Source: Healthy Living - The Huffington Post - June 29, 2015 Category: Consumer Health Advice Source Type: news

Bipolar and Fixable Probe Targeting Mitochondria to Trace Local Depolarization via Two-photon Fluorescence Lifetime Imaging
Analyst, 2015, Accepted ManuscriptDOI: 10.1039/C5AN01063B, PaperBenlei Wang, Xinfu Zhang, Chao Wang, Lingcheng Chen, Yi Xiao, Yi PangPolarization/depolarization levels of different single mitochondria in a cell are inhomogeneous, and always varying. Because depolarization is an indicator of mitochondrial dysfunction, tracing local depolarization is highly desirable. The existing...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 29, 2015 Category: Chemistry Authors: Benlei Wang Source Type: research

Diversity and plasticity of microglial cells in psychiatric and neurological disorders
Publication date: Available online 27 June 2015 Source:Pharmacology & Therapeutics Author(s): Yutaka Nakagawa , Kenji Chiba Recent advanced immunological analyses have revealed that the diversity and plasticity of macrophages lead to the identification of functional polarization states (classically activated M1 type and alternatively activated M2 type) which are dependent on the extracellular environment.  M1 and M2 polarization states of macrophages play an important role in controlling the balance between pro-inflammatory and anti-inflammatory conditions. Microglial cells are resident mononuclear phagocytes i...
Source: Pharmacology and Therapeutics - June 28, 2015 Category: Drugs & Pharmacology Source Type: research

[The Relationship of Suicide Attempts with Affective Temperament and Relevant Clinical Features in Patients with Mood Disorders].
CONCLUSION: The findings are expected to guadiance to preventing suicide in patients with affective disorders. The inclusion in this study of patients with different index episodes of illness, including manic, depressive and mixed periods, can be accepted as a significant limitation of this study. PMID: 26111285 [PubMed - in process] (Source: Turkish Journal of Psychiatry)
Source: Turkish Journal of Psychiatry - June 27, 2015 Category: Psychiatry Authors: Ekşioğlu S, Güleç H, Şimşek G, Semiz ÜB Tags: Turk Psikiyatri Derg Source Type: research

A Novel Bipolar Phosphorescent Host for Highly Efficient Deep-Red OLEDs at Wide Luminance Range of 1000-10000 cd m-2
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC04297F, CommunicationYansong Feng, Ping Li, Xuming Zhuang, Kaiqi Ye, Tai Peng, Yu Liu, Yue WangA novel phosphorescent host FPYPCA possessing the bipolar charge transporting ability realizes the most efficient deep-red PhOLED, which maintains very high-level EQEs of >23% at rather high and wide luminance...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - June 27, 2015 Category: Chemistry Authors: Yansong Feng Source Type: research

The use of cannabis as a predictor of early onset of bipolar disorder and suicide attempts - Leite RT, Nogueira Sde O, do Nascimento JP, de Lima LS, da Nóbrega TB, Virgínio Mda S, Moreno LM, Sampaio BH, Souza FG.
Introduction. Bipolar disorder (BD) implies risk of suicide. The age at onset (AAO) of BD carries prognostic significance. Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to revi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - June 27, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Justifying medication decisions in mental health care: Psychiatrists' accounts for treatment recommendations
Publication date: August 2015 Source:Social Science & Medicine, Volume 138 Author(s): Beth Angell , Galina B. Bolden Psychiatric practitioners are currently encouraged to adopt a patient centered approach that emphasizes the sharing of decisions with their clients, yet recent research suggests that fully collaborative decision making is rarely actualized in practice. This paper uses the methodology of Conversation Analysis to examine how psychiatrists justify their psychiatric treatment recommendations to clients. The analysis is based on audio-recordings of interactions between clients with severe mental illness...
Source: Social Science and Medicine - June 27, 2015 Category: Psychiatry & Psychology Source Type: research

Cariprazine Delays ouabain-evoked epileptiform Spikes and loss of activity in rat hippocampal Slices
In this study, we tested the ability of cariprazine a new antipsychotic candidate to block ouabain-induced changes in rat hippocampal slices. (Source: Psychiatry Research)
Source: Psychiatry Research - June 27, 2015 Category: Psychiatry Authors: Rif S. El-Mallakh, Ralphiel S. Payne, Avital Schurr, Yonglin Gao, Zhemin Lei, Béla Kiss, István Gyertyán, Nika Adham Source Type: research

The Effects of childhood abuse on self-reported psychotic Symptoms in severe mental illness: Mediating Effects of posttraumatic stress Symptoms
The present study examined the role of posttraumatic stress symptoms in the relationship between childhood abuse and self-reported psychotic symptoms in severe mental illness. A total of 126 patients diagnosed with major psychiatric conditions with comorbid symptoms of psychosis participated in the present study. The representative psychiatric diagnoses included schizophrenia, bipolar disorder with psychotic features, major depressive disorder with psychotic features, schizoaffective disorder, schizophreniform disorder, and delusional disorder. (Source: Psychiatry Research)
Source: Psychiatry Research - June 27, 2015 Category: Psychiatry Authors: Ji Young Choi, Young Min Choi, Bongseog Kim, Dong Woo Lee, Min Sook Gim, Soo Hyun Park Source Type: research

Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios as Inflammation Markers for Bipolar Disorder
In the present study we investigated the involvement of inflammatory cells and their ratios as inflammation markers in Bipolar Disorder. We have enrolled 61 manic, 55 euthymic patients and 54 control subjects to the study. Neutrophil-lymphocyte and platelet-lymphocyte ratios were found significantly higher in both manic and euthymic patients compared to control group. These findings suggest that the inflammatory cells have a role in the pathophysiology of bipolar disorder manic and even in euthymic state. (Source: Psychiatry Research)
Source: Psychiatry Research - June 27, 2015 Category: Psychiatry Authors: Tevfik Kalelioglu, Mustafa Akkus, Nesrin Karamustafalioglu, Abdullah Genc, Esra Sena Genc, Alparslan Cansiz, Murat Emul Source Type: research

Assessment of cytokıne levels and hs-CRP ın bıpolar I dısorder before and after treatment
We aimed to assess the relationship between cytokine levels and the severity of the manic period in medication free patients. 30 medication free patients and 28 healthy subjects (HS) were recruited. Plasma levels of pro-inflammatory, anti-inflammatory, inflammatory cytokines, and hs-CRP levels were investigated upon hospital admission, after six weeks follow up in bipolar disease manic episode and compared the results to HS. The severity of the manic episodes were assessed according to the Young mania rating scale. (Source: Psychiatry Research)
Source: Psychiatry Research - June 27, 2015 Category: Psychiatry Authors: Vesile Uyanik, Cengiz Tuglu, Yasemin Gorgulu, Hakan Kunduracilar, Mehmet Sevki Uyanik Source Type: research

Impaired conflict resolution and vigilance in euthymic bipolar disorder
In this study, we explored whether and which of the three attentional networks are altered in euthymic Bipolar Disorder (BD). (Source: Psychiatry Research)
Source: Psychiatry Research - June 27, 2015 Category: Psychiatry Authors: Andrea Marotta, Roberto Delle Chiaie, Alfredo Spagna, Laura Bernabei, Martina Sciarretta, Javier Roca, Massimo Biondi, Maria Casagrande Source Type: research

Obesity, but not metabolic syndrome, negatively affects outcome in bipolar disorder
ConclusionObesity and abdominal obesity, but not metabolic syndrome, were associated with less improvement after 6 months of lithium‐ or quetiapine‐based treatment. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - June 26, 2015 Category: Psychiatry Authors: S. L. McElroy, D. E. Kemp, E. S. Friedman, N. A. Reilly‐Harrington, L. G. Sylvia, J. R. Calabrese, D. J. Rabideau, T. A. Ketter, M. E. Thase, V. Singh, M. Tohen, C. L. Bowden, E. E. Bernstein, B. D. Brody, T. Deckersbach, J. H. Kocsis, G. Kinrys, W. V. Tags: Original Article Source Type: research

Potential eligibility of congenital heart disease patients for subcutaneous implantable cardioverter-defibrillator based on surface electrocardiogram mapping
Conclusion No significant differences were observed between S-ICD eligibility in C-CHD patients and controls. The AV and PV are most suitable in C-CHD patients. No significant impact of postural change was observed for S-ICD eligibility between the two groups. No significant difference was observed in S-ICD eligibility when screening using two or six postures in both groups. (Source: Europace)
Source: Europace - June 26, 2015 Category: Cardiology Authors: Zeb, M., Curzen, N., Veldtman, G., Yue, A., Roberts, P., Wilson, D., Morgan, J. Tags: Sudden death and ICDs Source Type: research

Chronobiology of Bipolar Disorder: Therapeutic Implication
Abstract Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder arise in part from a malfunction of the circadian system, linking the disease with an abnormal internal timing. Alterations in circadian rhythms and sleep are core elements in the disorders, characterizing both mania and depression and having recently been shown during euthymia. Several human genetic studies have implicated specific genes that make up the genesis of circadian rhythms in the manifestation of mood disorders with polymorphisms in molecular clock genes not only showing an association with the disorder but...
Source: Current Psychiatry Reports - June 26, 2015 Category: Psychiatry Source Type: research

Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis
In this study, we aimed to quantify the lifetime prevalence of anxiety disorders in individuals with bipolar disorder and compare it with rates in people without the disorder. Methods We searched the Web of Knowledge and Medline (through the PubMed interface) for articles published in any language from the database inception dates up until June 1, 2014, using a combination of the word “bipolar” and search terms for anxiety disorders. We included studies that reported original data about the lifetime prevalence of DSM-III and DSM-IV anxiety disorders in adults with bipolar disorder that recruited participants irrespect...
Source: The Lancet Psychiatry - June 26, 2015 Category: Psychiatry Source Type: research

Bipolar disorder and anxiety: a comorbidity needing better treatments
Publication date: Available online 23 June 2015 Source:The Lancet Psychiatry Author(s): Philip B Mitchell (Source: The Lancet Psychiatry)
Source: The Lancet Psychiatry - June 26, 2015 Category: Psychiatry Source Type: research

Nonconvulsive electrotherapy for treatment resistant unipolar and bipolar major depressive disorder: a proof-of-concept trial
Electroconvulsive therapy (ECT) is the most effective therapy for treatment resistant major depressive disorder (TRD); however, some individuals with TRD refuse ECT over concern about adverse cognitive effects. Clinical observation of two patients with TRD who had a therapeutic response to intended ECT despite having only one or no seizure suggested that nonconvulsive electrical stimulation may be effective in some patients. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 26, 2015 Category: Neurology Authors: William T. Regenold, Robert J. Noorani, Deborah Piez, Palak Patel Source Type: research

Safety and effectiveness of continuation antidepressant versus mood stabilizer monotherapy for relapse-prevention of bipolar II depression: A randomized, double-blind, parallel-group, Prospective study
Compare the safety and effectiveness of continuation antidepressant versus mood stabilizer monotherapy for preventing depressive relapse in bipolar II disorder. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - June 26, 2015 Category: Neurology Authors: Jay D. Amsterdam, Lorenzo Lorenzo-Luaces, Irene Soeller, Susan Qing Li, Jun J. Mao, Robert J. DeRubeis Source Type: research

Management of Complete Vagino-uterine Septum in Patients Seeking Fertility: Report of Two Cases and Review of Literature
Publication date: Available online 26 June 2015 Source:Gynecology and Minimally Invasive Therapy Author(s): Meei Jiun Seet , Matthew Lau , Jerry.K.Y. Chan , Heng Hao Tan Septate uterus is the most common congenital uterine anomaly encountered clinically. It is associated with infertility and adverse pregnancy outcomes including miscarriages and preterm births. Over the past few decades, the diagnosis and surgical management of uterine septum has changed significantly. Here, we present two women with complete vagino-uterine septum presenting with infertility. The diagnoses of septate uterus were made through three-dimensi...
Source: Gynecology and Minimally Invasive Therapy - June 26, 2015 Category: OBGYN Source Type: research

Irreversible Electroporation Can Effectively Ablate Hepatocellular Carcinoma to Complete Pathologic Necrosis
Conclusions This study demonstrates the efficacy of IRE for HCC based on pathologic evaluation and correlation to radiologic findings. (Source: Journal of Vascular and Interventional Radiology)
Source: Journal of Vascular and Interventional Radiology - June 26, 2015 Category: Radiology Source Type: research

Cemented bipolar hemiarthroplasty and neck fracture
Yurdakul E, Karaaslan F, Korkmaz M, Duygulu F, Baktır A (Source: Clinical Interventions in Aging)
Source: Clinical Interventions in Aging - June 25, 2015 Category: Geriatrics Source Type: research

Translational Research in Bipolar Disorders.
PMID: 26097751 [PubMed - in process] (Source: Neural Plasticity)
Source: Neural Plasticity - June 25, 2015 Category: Neurology Authors: Machado-Vieira R, Frey BN, Andreazza AC, Quevedo J Tags: Neural Plast Source Type: research

The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts.
Discussion. Cannabis use is associated with increased risk of suicide attempts and with early AAO. However, the effect of cannabis at the AAO and suicide attempts is not clear. PMID: 26097750 [PubMed - in process] (Source: Neural Plasticity)
Source: Neural Plasticity - June 25, 2015 Category: Neurology Authors: Leite RT, Nogueira Sde O, do Nascimento JP, de Lima LS, da Nóbrega TB, Virgínio Mda S, Moreno LM, Sampaio BH, Souza FG Tags: Neural Plast Source Type: research

Safety and tolerability of antipsychotic-mood stabilizer co-treatment in the management of acute bipolar disorder: results from a systematic review and exploratory meta-analysis
Expert Opinion on Drug Safety, Ahead of Print. (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - June 25, 2015 Category: Drugs & Pharmacology Tags: article Source Type: research

Gray‐matter loss greater in schizophrenia offspring than BD or control offspring
There is evidence that the biological underpinnings of schizophrenia and bipolar disorder (BD) are similar, although developmental trajectories show a difference in clinical onset. High‐risk studies show a genetic basis to both schizophrenia and bipolar disorder, with first‐degree relatives having a 10–15% risk. Using neuroimaging of children of patients with schizophrenia or bipolar disorder, researchers compared gray‐matter volume with that of controls and found great reductions in children and adolescents of patients with schizophrenia, but not in children or adolescents of patients with bipolar disorder or cont...
Source: The Brown University Child and Adolescent Psychopharmacology Update - June 25, 2015 Category: Psychiatry Tags: Schizophrenia Source Type: research

Genetic variation links creativity to psychiatric disorders
Nature Neuroscience 18, 928 (2015). doi:10.1038/nn.4047 Authors: Matthew C Keller & Peter M Visscher Epidemiological studies and anecdotal evidence show overlap between psychiatric disorders and creativity, but why? A new study uses genome-wide association data from schizophrenia and bipolar disorder to show that genetics are part of the explanation. (Source: Nature Neuroscience)
Source: Nature Neuroscience - June 25, 2015 Category: Neuroscience Authors: Matthew C KellerPeter M Visscher Tags: News and Views Source Type: research

Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by schizophrenia and bipolar disorder and controls
A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4,486 Schizophrenic patients and 4,477 controls served as the investigation sample. 3,521 Bipolar patients and 3,195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance. (Source: Psychiatry Research)
Source: Psychiatry Research - June 25, 2015 Category: Psychiatry Authors: Calabrò Marco, Drago. Antonio, Sidoti Antonina, Serretti Alessandro, Crisafulli Concetta Source Type: research

Evaluation of bipolar radiofrequency ablation for occluded self-expandable metal stents in the bile duct: in vivo and in vitro study
Conclusions: The presence of SEMSs attenuated the effect of bipolar endobiliary RFA. Tumorous tissue outside the SEMS is unlikely to be affected.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Endoscopy)
Source: Endoscopy - June 25, 2015 Category: Gastroenterology Authors: Yoon, Won JaeKim, Yong-TaeDaglilar, Ebubekir S.Mino-Kenudson, MariBrugge, William R. Tags: Innovations and brief communications Source Type: research

My Depression Is Not an Accessory
Largely among teens and young adults, there seems to be this false idea of what depression actually is. I've often heard the narrative of depression being embodied by two rebellious, black-clad lovers curled up on the hood of a car, cigarette smoke trailing figures around them. The pair whisper to each other, "I'm depressed," which is somehow supposed to make the situation all the more deeper and "cool." These beautified pictures of mental illness don't serve to show the excruciating monotony of depression, but instead dress it up as a way to achieve a deep personality. Views on mental illness have shifted from utter reje...
Source: Healthy Living - The Huffington Post - June 24, 2015 Category: Consumer Health Advice Source Type: news

Assessment of co-morbidity of adult separation anxiety in patients with bipolar disorder
Nordic Journal of Psychiatry, Ahead of Print. (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - June 24, 2015 Category: Psychiatry Tags: article Source Type: research

Medtech approvals: FDA releases April 2015 PMAs
The FDA released its list of the pre-market approvals it granted for medical devices in April 2015. Summary of PMA Originals & Supplements Approved Originals: 5 Supplements: 65 Summary of PMA Originals Under Review Total Under Review: 60 Total Active: 31 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 561 Total Active: 390 Total On Hold: 171 Summary of All PMA Submissions Originals: 4 Supplements: 87 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 65 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 154.1 FDA Time: 127.9 Days ...
Source: Mass Device - June 24, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news

Hope And Hype For New Type Of Antidepressant
Two brothers – one an entrepreneur, the other a Columbia University psychiatrist – are claiming today that a new combination of experimental medicines may prevent suicidal thoughts in people with bipolar disorder. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 24, 2015 Category: Pharmaceuticals Authors: Matthew Herper Source Type: news

Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
Conclusions: PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins (MAPs). Our finding of PIWIL1’s function in neuronal development implies conserved functions of molecules participating in morphogenesis of brain and germline tissue and provides a mechanism as to how mutations of PIWI may be associated with autism. (Source: Molecular Brain)
Source: Molecular Brain - June 24, 2015 Category: Neuroscience Authors: Ping-ping ZhaoMao-jin YaoSi-yuan ChangLan-tao GouMo-fang LiuZi-long QiuXiao-bing Yuan Source Type: research

Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses
Conclusions: Quantifying phenotypic patterns of illness beyond bipolar subtype can provide more detailed clinical disease characteristics for biomarker research, including genomic-risk studies. Future research can harness clinically useful biomarkers using state-of-the-art research technology to help stage disease burden and better individualize treatment selection for patients with bipolar disorder. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - June 24, 2015 Category: Psychiatry Authors: Mark FryeSusan McElroyManuel FuentesBruce SutorKathryn SchakChristine GalardyBrian PalmerMiguel PrietoSimon KungChristopher SolaEuijung RyuMarin VeldicJennifer GeskeAlfredo Cuellar-BarbozaLisa SeymourNicole MoriScott CroweTeresa RummansJoanna Biernacka Source Type: research

SAPHRIS approved for pediatric manic or mixed bipolar I
The Food and Drug Administration in March approved the supplemental new drug application of Actavis for SAPHRIS (asenapine) as a monotherapy for the acute treatment of manic or mixed episodes associated with bipolar I disorder in pediatric patients (ages 10–17). SAPHRIS is the only atypical antipsychotic treatment option with a sublingual (under the tongue) formulation. (Source: The Brown University Child and Adolescent Psychopharmacology Update)
Source: The Brown University Child and Adolescent Psychopharmacology Update - June 24, 2015 Category: Psychiatry Tags: From the FDA Source Type: research

Integrated theory to unify status among schizophrenia and manic depressive illness
Tryptophan hydroxylase 1 is primarily expressed in the gastrointestinal tract, and has been associated with both schizophrenia and depression. Although decreased serotonin activity has been reported in both depression and mania, it is important to investigate the interaction between serotonin and other neurotransmitter systems.There are competitive relationships between branched-chain amino acids, and tryptophan and tyrosine that relate to physical activity, and between L-3,4-dihydroxyphenylalanine (L-DOPA) and 5-hydroxytryptophan (5-HTP), both highly dependent on intracellular tetrahydrobiopterin concentrations. (Source: Medical Hypotheses)
Source: Medical Hypotheses - June 24, 2015 Category: Biomedical Science Authors: K. Fukuda Source Type: research

MedicationDiscountCard.com Now Offering National Discounts On Leading...
Drugs for the treatment of clinical depression, bipolar and other mental health conditions represent one of the strongest markets in the entire pharmaceutical industry. Since the introduction of the...(PRWeb June 23, 2015)Read the full story at http://www.prweb.com/releases/2015/06/prweb12804111.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - June 23, 2015 Category: Pharmaceuticals Source Type: news

Preliminary Transcriptome Analysis in Lymphoblasts from Cluster Headache and Bipolar Disorder Patients Implicates Dysregulation of Circadian and Serotonergic Genes
Abstract Bipolar disorder (BD) and cluster headache (CH) are distinct conditions with important similarities such as a temporal pattern of disturbances, dysregulation of the sleep–wake cycle, and response to lithium treatment in a proportion of patients. Aiming to identify common transcription signatures in these two disorders, we carried out an exploratory microarray gene expression analysis in lymphoblasts from 8 CH and 10 BD I patients selected for positive response to lithium and 10 healthy controls (CO). Gene expression levels of BD and CH were compared with CO to create two lists of differentially express...
Source: Journal of Molecular Neuroscience - June 23, 2015 Category: Neuroscience Source Type: research

Individualized differential diagnosis of schizophrenia and mood disorders using neuroanatomical biomarkers
Magnetic resonance imaging-based markers of schizophrenia have been repeatedly shown to separate patients from healthy controls at the single-subject level, but it remains unclear whether these markers reliably distinguish schizophrenia from mood disorders across the life span and generalize to new patients as well as to early stages of these illnesses. The current study used structural MRI-based multivariate pattern classification to (i) identify and cross-validate a differential diagnostic signature separating patients with first-episode and recurrent stages of schizophrenia (n = 158) from patients with major depression ...
Source: Brain - June 23, 2015 Category: Neurology Authors: Koutsouleris, N., Meisenzahl, E. M., Borgwardt, S., Riecher-Rossler, A., Frodl, T., Kambeitz, J., Kohler, Y., Falkai, P., Moller, H.-J., Reiser, M., Davatzikos, C. Tags: Original Articles Source Type: research

Brain structure-function associations in multi-generational families genetically enriched for bipolar disorder
Recent theories regarding the pathophysiology of bipolar disorder suggest contributions of both neurodevelopmental and neurodegenerative processes. While structural neuroimaging studies indicate disease-associated neuroanatomical alterations, the behavioural correlates of these alterations have not been well characterized. Here, we investigated multi-generational families genetically enriched for bipolar disorder to: (i) characterize neurobehavioural correlates of neuroanatomical measures implicated in the pathophysiology of bipolar disorder; (ii) identify brain–behaviour associations that differ between diagnostic g...
Source: Brain - June 23, 2015 Category: Neurology Authors: Fears, S. C., Schur, R., Sjouwerman, R., Service, S. K., Araya, C., Araya, X., Bejarano, J., Knowles, E., Gomez-Makhinson, J., Lopez, M. C., Aldana, I., Teshiba, T. M., Abaryan, Z., Al-Sharif, N. B., Navarro, L., Tishler, T. A., Altshuler, L., Bartzokis, Tags: Original Articles Source Type: research

Connectome signatures of neurocognitive abnormalities in euthymic bipolar I disorder
Conclusions This study suggests that structural connectome changes underlie abnormalities in fMRI activation and cognitive performance in euthymic BPI subjects. Results support that BA47 structural connectome changes may be a trait marker for BPI. Future studies are needed to determine if these “connectome signatures” may also confer a biological risk and/or serve as predictors of relapse. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - June 23, 2015 Category: Psychiatry Source Type: research

Quality of life and risk of psychiatric disorders among regular users of alcohol, nicotine, and cannabis: An analysis of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC)
Publication date: July–August 2015 Source:Journal of Psychiatric Research, Volumes 66–67 Author(s): Jesse R. Cougle , Jahn K. Hakes , Richard J. Macatee , Jesus Chavarria , Michael J. Zvolensky Research is limited on the effects of regular substance use on mental health-related outcomes. We used a large nationally representative survey to examine current and future quality of life and risk of psychiatric disorders among past-year regular (weekly) users of alcohol, nicotine, and cannabis. Data on psychiatric disorders and quality of life from two waves (Wave 1 N = 43,093, Wave 2 N = 34,653) of the National Epide...
Source: Journal of Psychiatric Research - June 23, 2015 Category: Psychiatry Source Type: research

Subcortical Volumes Differentiate Major Depressive Disorder, Bipolar Disorder, and Remitted Major Depressive Disorder
In this study, we examined differences in subcortical gray matter volumes among euthymic BD, MDD, remitted MDD (RMD), and healthy (CTL) individuals. Using automated gray matter segmentation of T1-weighted MRI images, we estimated volumes of 16 major subcortical gray matter structures in 40 BD, 57 MDD, 35 RMD, and 61 CTL individuals. We used multivariate analysis of variance to examine group differences in these structures, and support vector machines (SVMs) to assess individual-by-individual classification. Analyses yielded significant group differences for caudate (p = 0.029) and ventral diencephalon (VD) volumes (p = 0.0...
Source: Journal of Psychiatric Research - June 23, 2015 Category: Psychiatry Source Type: research

Disturbed Sleep as Risk Factor for the subsequent onset of Bipolar Disorder – Data from a 10-year prospective-longitudinal study among adolescents and young adults
Publication date: Available online 16 June 2015 Source:Journal of Psychiatric Research Author(s): Philipp S. Ritter , Michael Höfler , Hans Ulrich Wittchen , Roselind Lieb , Michael Bauer , Andrea Pfennig , Katja Beesdo-Baum There is ample data suggesting that individuals with bipolar disorder more frequently suffer from disturbed sleep even when euthymic. Since sleep is a process that is crucial for affective homeostasis, disturbed sleep in healthy individuals may be a risk factor for the subsequent onset of bipolar disorder. Utilizing data from a large cohort of adolescents and young adults, this study tests the hypot...
Source: Journal of Psychiatric Research - June 23, 2015 Category: Psychiatry Source Type: research

Plasma Linoleic Acid Partially Mediates the Association of Bipolar Disorder on Self-Reported Mental Health Scales
Publication date: Available online 14 June 2015 Source:Journal of Psychiatric Research Author(s): Simon J. Evans , Shervin Assari , Gloria J. Harrington , Ya-Wen Chang , Charles F. Burant , Melvin G. McInnis We have shown that bipolar individuals have reduced quality diets, including lower intake of polyunsaturated fatty acids (PUFA). We have also reported reduced plasma levels of the n-6 PUFA, linoleic acid (LA), and the n-3 PUFA, eicosapentaenoic acid (EPA) in bipolar subjects. In the current analysis we hypothesized that LA and EPA plasma levels would mediate lower self-reported mental health and life functioning scor...
Source: Journal of Psychiatric Research - June 23, 2015 Category: Psychiatry Source Type: research

Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study
Keshavan & G D Pearlson (Source: Translational Psychiatry)
Source: Translational Psychiatry - June 23, 2015 Category: Psychiatry Authors: B NarayananP SohV D CalhounG RuañoM KocherlaA WindemuthB A ClementzC A TammingaJ A SweeneyM S KeshavanG D Pearlson Source Type: research

Prefrontal gyrification in psychotic bipolar I disorder vs. schizophrenia
Bipolar disorder and schizophrenia share phenotypic and genotypic features, but might differ in aspects of abnormal neurodevelopmental trajectories. We studied gyrification, a marker of early developmental pathology, in high-resolution MRI scans of 34 patients with schizophrenia, 17 euthymic bipolar I disorder patients with previous psychotic symptoms, and 34 matched healthy controls in order to test the hypothesis of overlapping and diverging prefrontal gyrification abnormalities. We applied a novel, validated method for measuring local gyrification in each vertex point of the reconstructed cortical surface. (Source: Jour...
Source: Journal of Affective Disorders - June 23, 2015 Category: Neurology Authors: Igor Nenadic, Raka Maitra, Maren Dietzek, Kerstin Langbein, Stefan Smesny, Heinrich Sauer, Christian Gaser Source Type: research

Conversion from depression to bipolar disorder in a cohort of young people in England, 1999–2011: A national record linkage study
To estimate the conversion rate from unipolar depression (ICD10 codes F32 – F33) to bipolar disorder (BP) (ICD10 codes F31) in an English national cohort. It was hypothesised that early–onset BP (age (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - June 23, 2015 Category: Neurology Authors: Anthony James, Michael Goldacre, Clare J Wotton, Uy Hoang, Anne Duffy Source Type: research

Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients
The molecular understanding of bipolar disorder (BD) aetiology has advanced over the last years through the identification of peripheral disease biomarkers. Here, we have attempted to identify plasma biomarkers associated with distinct BD mood states. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - June 23, 2015 Category: Neurology Authors: Frieder Haenisch, Murtada Alsaif, Paul C. Guest, Hassan Rahmoune, Robert H. Yolken, Faith Dickerson, Sabine Bahn Tags: Research report Source Type: research