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Corrigendum to “Effect of adjunctive benzodiazepines on clinical outcomes in lithium- or quetiapine-treated outpatients with bipolar I or II disorder: Results from the bipolar CHOICE trial” [J. Affect. Disord. 161 (2014) 30–35]
We recently became aware of an error that occurred when constructing the “complex polypharmacy” variable for our inverse probability weighted analysis of clinical outcome conditional on benzodiazepine use in the Bipolar CHOICE sample. The error resulted in an over-inclusion of individuals classified as having been treated with complex polypharmacy. This misclassification occurred in both benzodiazepine initiators and non-initiators and did not affect our results or conclusions. Nevertheless, we believe that it is our responsibility to report the error and updated results. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 29, 2014 Category: Neurology Authors: William V. Bobo, Noreen A. Reilly-Harrington, Terence A. Ketter, Benjamin D. Brody, Gustavo Kinrys, David E. Kemp, Richard C. Shelton, Susan L. McElroy, Louisa G. Sylvia, James H. Kocsis, Melvin G. McInnis, Edward S. Friedman, Vivek Singh, Mauricio Tohen, Tags: Corrigenda Source Type: research

Researchers develop passive, voice analysis mood detection app for patients with bipolar disorder
Researchers at the University of Michigan are developing an app that monitors a person’s voice during phone calls to detect mood changes in people who have bipolar disorder. The app, called PRIORI, still needs more testing before it can be commercialized, the researchers said, but a small pilot study of six individuals with bipolar disorder has shown the […] (Source: mobihealthnews)
Source: mobihealthnews - July 28, 2014 Category: Information Technology Authors: Aditi Pai Tags: Uncategorized Bipolar disorder app PRIORI University of Michigan Source Type: news

Melanie de Blank: I'm so proud of Polly, my bipolar daughter
A year after her daughter Polly's death, Melanie de Blank says that poor services and the stigma associated with mental illness hurt thousands (Source: Telegraph Health)
Source: Telegraph Health - July 28, 2014 Category: Consumer Health News Source Type: news

Unipolar Peak Negative Voltage as an Endocardial Electrographic Characteristic to Predict Overlying Abnormal Epicardial Substrates in Patients with Right Epicardial Ventricular Tachycardia
ConclusionsIn patients with RV epicardial ventricular tachycardia, the presence of unipolar peak‐negative voltage of <1.66 mV in the endocardium predicted the presence of epicardial dense scar (<0.5 mV) and potential ablation targets in the overlying epicardium.This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - July 28, 2014 Category: Cardiology Authors: PO‐CHING CHI, YENN‐JIANG LIN, SHIH‐LIN CHANG, LI‐WEI LO, YU‐FENG HU, TZE‐FAN CHAO, FA‐PO CHUNG, JONAN LIAO, TA‐CHUAN TUAN, JEN‐YUAN KUO, JIN‐LONG HUANG, SHIH‐ANN CHEN Tags: Original Article Source Type: research

Should You Take Zoloft for Bipolar Disorder?
Some of the most common Zoloft side effects are sweating, stomach problems and headache. Blurred vision and others are among the less common, some of which can be serious. If you are taking Zoloft for bipolar disorder, depression or any other condition, knowing all the potential side effects is important. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 28, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

Illness-course modulates suicidality-related prefrontal gray matter reduction in women with bipolar disorder - Lijffijt M, Rourke ED, Swann AC, Zunta-Soares GB, Soares JC.
OBJECTIVE: Explore interrelationships between suicide attempt history (Objective 1) or suicide attempt severity (Objective 2) with prefrontal cortex gray matter (PFCGM ) volume and illness-course in patients with bipolar disorder (BD). METHOD: Nine... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 26, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Brief report novel mechanism for valproate‐induced teratogenicity
Conclusion: If these data translate to the overall transport and subsequent bioavailability of folates, noncompetitive inhibition of the folate receptors by VPA may serve to lower the bioavailable folates in VPA treated mothers. This represents a novel mechanism by which in utero VPA exposure could be disrupting developmental processes by noncompetitively binding to the folate receptors during embryogenesis, thus inducing the wide range of defects seen in babies born to VPA treated mothers. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 26, 2014 Category: Perinatology & Neonatology Authors: Kristin Fathe, Ana Palacios, Richard H. Finnell Tags: Brief Report Source Type: research

Should You Take Lexapro for Your Bipolar...
Information about Lexapro (generic escitalopram) including basic information, precautions and warnings, common side effects, and information about Lexapro and pregnancy. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 26, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

A web-based self-management intervention for bipolar disorder ‘Living with bipolar’: A feasibility randomised controlled trial
This study assessed the feasibility and potential effectiveness of a recovery informed web-based self-management intervention for people with BD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 26, 2014 Category: Neurology Authors: Nicholas J. Todd, Steven H. Jones, Anna Hart, Fiona A. Lobban Source Type: research

Post-discharge suicides of inpatients with bipolar disorder in Finland - Isometsä E, Sund R, Pirkola S.
OBJECTIVES: Suicide risk in psychiatric inpatients is known to be remarkably high after discharge. However, temporal patterns and risk factors among patients with bipolar disorder remain obscure. We investigated post-discharge temporal patterns of hazard a... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 25, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

Photostable Bipolar Fluorescent Probe for Video Tracking Plasma Membranes Related Cellular Processes
ACS Applied Materials & InterfacesDOI: 10.1021/am503849c (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - July 25, 2014 Category: Materials Science Authors: Xinfu Zhang, Chao Wang, Liji Jin, Zhuo Han and Yi Xiao Source Type: research

A novel channel selection method for multiple motion classification using high-density electromyography
Conclusions: The proposed MCCSP method would be a practicable means in channel selection and would facilitate the design of practical myoelectric control systems in the active rehabilitation of mildly-impaired TBI patients and in other rehabilitation applications such as the multifunctional myoelectric prostheses for limb amputees. (Source: BioMed Central)
Source: BioMed Central - July 25, 2014 Category: Journals (General) Authors: Yanjuan GengXiufeng ZhangYuan-Ting ZhangGuanglin Li Source Type: research

Population study of disease burden, management, and treatment of bipolar disorder in Sweden: a retrospective observational registry study
ConclusionsIn Sweden, the incidence and prevalence of diagnosed bipolar disorder have increased during the last 20 years. Compared to the general population, these patients had similar education levels, lower employment levels, less disposable income, more sick leave, and twice the mortality. A trend towards earlier diagnosis, more use of antidepressants, and less use of lithium was seen. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 24, 2014 Category: Psychiatry Authors: Andreas Carlborg, Lena Ferntoft, Marcus Thuresson, Johan Bodegard Tags: Original Article Source Type: research

The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial
ConclusionCariprazine demonstrated superior efficacy versus placebo and was generally well tolerated in patients experiencing acute manic or mixed episodes associated with bipolar I disorder. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 24, 2014 Category: Psychiatry Authors: Suresh Durgam, Anju Starace, Dayong Li, Raffaele Migliore, Adam Ruth, György Németh, István Laszlovszky Tags: Original Article Source Type: research

What Are Benzodiazepine Medications Used to...
Information about the benzodiazepine family of medications, generally used to treat anxiety and related conditions, including Valium, Librium, Xanax and several others. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 24, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

Everything You Need to Know About Topamax/Topir...
Topamax - generic topiramate - is an anticonvulsant approved for use in treating epilepsy and migraine headaches. It is also frequently prescribed off-label for bipolar disorder. Information on uses, major warnings, and the effectiveness of Topamax for weight loss. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 24, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

Structural Basis of LC8-mediated Ana2 Oligomerization [Protein Structure and Folding]
We present two independent atomic structures of LC8 dimers in complex with Ana2 LC8-binding site 1 and site 2 peptides. The Ana2 peptides form β-strands that extend a central composite LC8 β-sandwich. LC8 recognizes the signature TQT motif in the first LC8 binding site of Ana2, forming extensive van der Waals contacts and hydrogen bonding with the peptide, whereas the Ana2 site 2 TQC motif forms a uniquely extended β-strand, not observed in other dynein light chain-target complexes. Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2...
Source: Journal of Biological Chemistry - July 24, 2014 Category: Chemistry Authors: Slevin, L. K., Romes, E. M., Dandulakis, M. G., Slep, K. C. Tags: Protein Structure and Folding Source Type: research

Cost-Effectiveness of Asenapine in the Treatment of Patients with Bipolar I Disorder with Mixed Episodes in an Italian Context.
CONCLUSIONS: Results from this study suggest that the management of bipolar I patients with mixed episodes using ASE as alternative to OLA can lead to cost saving for the Italian NHS and improve patients quality of life. PMID: 25055791 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - July 24, 2014 Category: Drugs & Pharmacology Authors: Caresano C, Di Sciascio G, Fagiolini A, Maina G, Perugi G, Ripellino C, Vampini C Tags: Adv Ther Source Type: research

New funds jump-start mental illness research
What will happen in the field of serious mental illness when human need, scientific progress and a major influx of funding converge? Scientists on Tuesday predicted that the world could see the same kind of progress in understanding schizophrenia and bipolar disorder that's been seen in the... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - July 23, 2014 Category: Science Source Type: news

Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder
ConclusionsPrior linkage evidence and our findings suggest NPTX1 as a novel candidate gene for BD. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 23, 2014 Category: Psychiatry Authors: Anto P Rajkumar, Jane H Christensen, Manuel Mattheisen, Iben Jacobsen, Iben Bache, Jonatan Pallesen, Jakob Grove, Per Qvist, Andrew McQuillin, Hugh M Gurling, Zeynep Tümer, Ole Mors, Anders D Børglum Tags: Brief Report Source Type: research

Decision-making and trait impulsivity in bipolar disorder are associated with reduced prefrontal regulation of striatal reward valuation
Bipolar disorder is characterized by impaired decision-making captured in impulsivity and risk-taking. We sought to determine whether this is driven by a failure to effectively weight the lower-order goal of obtaining a strongly desired reward in relation to higher-order goals, and how this relates to trait impulsivity and risk-taking. We hypothesized that in bipolar disorder the weighting of valuation signals converging on ventromedial prefrontal cortex are more heavily weighted towards ventral striatum inputs (lower-order), with less weighting of dorsolateral prefrontal cortex inputs (higher-order). Twenty euthymic patie...
Source: Brain - July 23, 2014 Category: Neurology Authors: Mason, L., O'Sullivan, N., Montaldi, D., Bentall, R. P., El-Deredy, W. Tags: Original Articles Source Type: research

Myelination, oligodendrocytes, and serious mental illness
Historically, the human brain has been conceptually segregated from the periphery and further dichotomized into gray matter (GM) and white matter (WM) based on the whitish appearance of the exceptionally high lipid content of the myelin sheaths encasing neuronal axons. These simplistic dichotomies were unfortunately extended to conceptually segregate neurons from glia, cognition from behavior, and have been codified in the separation of clinical and scientific fields into medicine, psychiatry, neurology, pathology, etc. The discrete classifications have helped obscure the importance of continual dynamic communication betwe...
Source: Glia - July 23, 2014 Category: Neurology Authors: V. Haroutunian, P. Katsel, P. Roussos, K. L. Davis, L. L. Altshuler, G. Bartzokis Tags: Review Article Source Type: research

Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: A proton magnetic resonance spectroscopy study
Depression in the context of bipolar disorder (BD) is often misdiagnosed as major depressive disorder (MDD), leading to mistreatments and poor clinical outcomes for many bipolar patients. Previous neuroimaging studies found mixed results on brain structure, and biochemical metabolism of the two disorders. To eliminate the compounding effects of medication, and aging, this study sought to investigate the brain biochemical changes of treatment-naïve, non-late-life patients with MDD and BD in white matter in prefrontal (WMP) lobe, anterior cingulate cortex (ACC) and hippocampus by using proton magnetic resonance spectroscopy...
Source: Journal of Affective Disorders - July 23, 2014 Category: Neurology Authors: Shuming Zhong, Ying Wang, Guoxiang Zhao, Qi Xiang, Xueying Ling, Sirun Liu, Li Huang, Yanbin Jia Source Type: research

New Schizophrenia Genes IdentifiedNew Schizophrenia Genes Identified
Eighty-three novel genes linked to schizophrenia, including one that also raises the risk for bipolar disorder and alcoholism, have been identified. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - July 22, 2014 Category: Psychiatry Tags: Psychiatry News Source Type: news

Electrical Stimulation of the Ventral Tegmental Area Induces Reanimation from General Anesthesia
Background: Methylphenidate or a D1 dopamine receptor agonist induces reanimation (active emergence) from general anesthesia. The authors tested whether electrical stimulation of dopaminergic nuclei also induces reanimation from general anesthesia. Methods: In adult rats, a bipolar insulated stainless steel electrode was placed in the ventral tegmental area (VTA, n = 5) or substantia nigra (n = 5). After a minimum 7-day recovery period, the isoflurane dose sufficient to maintain loss of righting was established. Electrical stimulation was initiated and increased in intensity every 3 min to a maximum of 120 µA. If stimulat...
Source: Anesthesiology - July 22, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Basic Science Source Type: research

Maternal hypothyroidism and psychiatric disease
Psychiatric disease, manifesting as depression, bipolar disease and schizophrenia, is a leading cause of disease in adolescents and young adults. Although the aetiology of psychiatric diseases is only partly understood, it is believed that the causation may start early in life. Andersen et al. hypothesized that maternal hypothyroidism during pregnancy could programme the foetus to develop psychiatric disease later in life. To examine this hypothesis, they used Danish nationwide registers and identified a cohort of adolescents and obtained information on their use of anxiolytics, antipsychotics and antidepressants from th...
Source: Society for Endocrinology - July 22, 2014 Category: Endocrinology Source Type: news

Cardiovascular risk factors among bipolar disorder patients admitted to an inpatient unit of a tertiary care hospital in India.
CONCLUSIONS: Findings of the present study suggest the presence of cardiovascular risk factors and higher rate of metabolic syndrome in patients with bipolar disorder. Considering this fact, there is an urgent need for routine screening for cardiovascular risk factors in these patients. Mental health professionals should be aware of these risks; there is need to develop preventive strategies to reduce the cardiovascular risk in this population. PMID: 25042952 [PubMed - in process] (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - July 22, 2014 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Son's Mental Illness Prompts Billionaire's Big Donation To Psychiatric Research
Ted Stanley is giving $650 million to the Broad Institute of MIT and Harvard to find and treat the genetic underpinnings of mental illnesses. His son has bipolar disorder.» E-Mail This (Source: NPR Health and Science)
Source: NPR Health and Science - July 22, 2014 Category: Consumer Health News Source Type: news

UCLA faculty contribute to international study on the biology behind schizophrenia
UCLA researchers were part of a multinational effort that has identified more than 100 locations in the human genome associated with the risk of developing schizophrenia. The study, the largest genomic study published on any psychiatric disorder to date, provides important new insights about the biological causes of schizophrenia, and it could lead to new approaches to treatment. The report was published in the July 22 online edition of the journal Nature. "As recently as five years ago, we still lacked proof that mental disorders had a genetic basis," said Dr. Nelson Freimer, a UCLA professor of psychiatry and director of...
Source: UCLA Newsroom: Health Sciences - July 22, 2014 Category: Universities & Medical Training Source Type: news

All the world’s a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective
All the world’s a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective Molecular Psychiatry advance online publication, July 22 2014. doi:10.1038/mp.2014.71 Authors: E Frank, V L Nimgaonkar, M L Phillips & D J Kupfer (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - July 22, 2014 Category: Psychiatry Authors: E FrankV L NimgaonkarM L PhillipsD J Kupfer Source Type: research

Endogenous calcium buffering at photoreceptor synaptic terminals in salamander retina
Abstract Calcium operates by several mechanisms to regulate glutamate release at rod and cone synaptic terminals. In addition to serving as the exocytotic trigger, Ca2+ accelerates replenishment of vesicles in cones and triggers Ca2+‐induced Ca2+ release (CICR) in rods. Ca2+ thereby amplifies sustained exocytosis, enabling photoreceptor synapses to encode constant and changing light. A complete picture of the role of Ca2+ in regulating synaptic transmission requires an understanding of the endogenous Ca2+ handling mechanisms at the synapse. We therefore used the “added buffer” approach to measure the endogenous Ca2+ ...
Source: Synapse - July 22, 2014 Category: Neurology Authors: Matthew J. Van Hook, Wallace B. Thoreson Tags: Research Article Source Type: research

Buzz Aldrin, Ph.D. (Colonel, USAF, Ret.) - Not...
Edwin Eugene Aldrin, Jr. (aka Buzz) was one of the earliest astronauts in the NASA program. The highlights of his career include the record for time spent in space outside of a craft and he was the second person to step foot on the moon. He has authored a number of books about his experiences and he has been very open about his personal struggles with mental illness and alcoholism. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 22, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

How Can Family Members Help Those With Bipolar...
Community member llb asks her spouse to forgive angry outbursts when her bipolar disorder is speaking, to hold her when she is scared, and to know when she is truly suicidal and when she is only venting. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 22, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

Analysis of Genes in Serotonin Pathway with Attention and Executive Function in Patients with Bipolar Affective Disorder
The reason why it is difficult to identify susceptibility genes attributed to bipolar disorder (BPD) is the phenotypic heterogeneity. The use of endophenotypes has been advocated as one possible strategy to discovery cause variants of BPD. (Source: Comprehensive Psychiatry)
Source: Comprehensive Psychiatry - July 22, 2014 Category: Psychiatry Authors: Zhenxing Yang, Yin Lin, Lijie Guan, Xuan Li, Wei Deng, Zeyu Jiang, Guohui Lao, Qiang Wang, Xiaoyu Hao, Xiang Liu, Yingcheng Wang, Lianshen Zhao, Xiaohong Ma, Liping Cao, Tao Li Source Type: research

A Clinically useful self-report measure of the DSM-5 mixed Features specifier of major depressive disorder
To acknowledge the clinical significance of manic features in depressed patients, DSM-5 included criteria for a mixed features specifier for major depressive disorder (MDD). In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project we modified our previously published depression scale to include a subscale assessing the DSM-5 mixed features specifier. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 22, 2014 Category: Neurology Authors: Mark Zimmerman, Iwona Chelminski, Diane Young, Kristy Dalrymple, Jennifer H. Martinez Source Type: research

A $650 Million Donation for Psychiatric Research
As research into mental illness sputters, the father of a man effectively treated for bipolar disorder is donating $650 million to the cause through his foundation. (Source: NYT Health)
Source: NYT Health - July 21, 2014 Category: Consumer Health News Authors: By CARL ZIMMER and BENEDICT CAREY Tags: Genetics and Heredity Mental Health and Disorders Stanley, Jonathan Research Bipolar Disorder Source Type: news

Combined treatment: impact of optimal psychotherapy and medication in bipolar disorder
ConclusionsCombined pharmacological and adjunctive psychosocial treatments appeared to provide an improved course of illness compared to the results of previous studies. Efforts to further improve the course of illness beyond that provided by current optimal treatment regimens will require a substantial focus on both subsyndromal and syndromal depressive symptoms. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 21, 2014 Category: Psychiatry Authors: Sagar V Parikh, Lisa D Hawke, Vytas Velyvis, Ari Zaretsky, Serge Beaulieu, Irene Patelis‐Siotis, Glenda MacQueen, L Trevor Young, Lakshmi N Yatham, Pablo Cervantes Tags: Original Article Source Type: research

Adverse childhood experiences worsen cognitive distortion during adult bipolar depression
Cognitive distortion is a central feature of depression, encompassing negative thinking, dysfunctional personality styles and dysfunctional attitudes. It has been hypothesised that ACE could increase the vulnerability to depression by contributing to the development of a stable negative cognitive style. Nevertheless, little research has been carried out on possible associations between adverse childhood experiences (ACEs) and cognitive distortion, and whether any gender differences exist.AimThe aim of this study was to examine the association between ACEs and cognitive distortions and possible differences between genders i...
Source: Comprehensive Psychiatry - July 21, 2014 Category: Psychiatry Authors: Sara Poletti, Cristina Colombo, Francesco Benedetti Source Type: research

Morning cortisol levels in schizophrenia and bipolar disorder: A meta-analysis
Schizophrenia and bipolar disorder are severe neuropsychiatric disorders likely caused by an interaction of multiple biological and environmental factors, with a prominent role for stress-related pathology proposed within current diathesis-stress models of illness development (Rethelyi et al., 2013). Shared environmental risk factors have been estimated to account for 3-6% of vulnerability for schizophrenia and bipolar disorder (Lichtenstein et al., 2009), and include a higher prevalence of pre- or post-natal insults (Demjaha et al., 2012; Murray et al., 2004), early childhood maltreatment (Aas et al., 2011), and/or cannab...
Source: Psychoneuroendocrinology - July 21, 2014 Category: Psychiatry Authors: Leah Girshkin, Sandra L. Matheson, Alana M. Shepherd, Melissa J. Green Source Type: research

Clinical course of the bipolar II disorder in a Japanese sample
(Background) The bipolar II disorder has been recognized a mental disorder distinctive from the bipolar I disorder, showing the stability of diagnosis in prospective studies. However, the characterization of the bipolar II disorder still remains under investigation.(Methods) The present study was conducted on consecutively admitted bipolar II inpatients diagnosed by DSM-IV-TR to delineate the clinical features.(Results) The types of initial mood disorders of the bipolar II inpatients were divided into four groups, i.e., major depressive episode (MDE), hypomanic episode (HME), dysthymic and cyclothymic disorders. (Source: J...
Source: Journal of Affective Disorders - July 21, 2014 Category: Neurology Authors: Akeo Kurumaji, Kenji Narushima, Kazunari Ooshima, Tomoaki Yukizane, Mitsuhiro Takeda, Toru Nishikawa Source Type: research

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase with constitutive activity involved in cellular architecture, gene expression, cell proliferation, fate decision and apoptosis, among others. GSK-3 expression is particularly high in brain where it may be involved in neurological and psychiatric disorders such as Alzheimer’s disease, bipolar disorder and major depression. A link with schizophrenia is suggested by the antipsychotic drug-induced GSK-3 regulation and by the involvement of the Akt/GSK-3 pathway in dopaminergic neurotransmission. (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - July 21, 2014 Category: Psychiatry & Psychology Authors: Raquel Gomez-Sintes, Analia Bortolozzi, Francesc Artigas, José J. Lucas Source Type: research

Behavioral approach system sensitivity and risk taking interact to predict left-frontal EEG asymmetry.
Abstract The Behavioral Approach System (BAS) hypersensitivity theory of bipolar disorder (BD; Alloy & Abramson, 2010; Depue & Iacono, 1989) suggests that hyperreactivity in the BAS results in the extreme fluctuations of mood characteristic of BD. In addition to risk conferred by BAS hypersensitivity, cognitive and personality variables may play a role in determining risk. We evaluated relationships among BAS sensitivity, risk taking, and an electrophysiological correlate of approach motivation, relative left-frontal electroencephalography (EEG) asymmetry. BAS sensitivity moderated the relationship between ...
Source: Behavior Therapy - July 20, 2014 Category: Psychiatry & Psychology Authors: Black CL, Goldstein KE, LaBelle DR, Brown CW, Harmon-Jones E, Abramson LY, Alloy LB Tags: Behav Ther Source Type: research

When You Shouldn’t Drink Grapefruit Juice...
Drinking grapefruit juice can cause serious problems with your medications. Here's why, and a partial list of drugs that can be affected. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 20, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

How to Recognize a Manic or Hypomanic Episode
Here's what you need to watch for that may signal someone you know is starting into or having a bipolar manic or hypomanic episode. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 20, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

3 Red Flags That Could Signal Bipolar Disorder
Learn how to tell when your experiences are normal and when they’ve pushed into the extremes of depression or mania associated with bipolar disorder. (Source: Bipolar Disorder)
Source: Bipolar Disorder - July 20, 2014 Category: Psychiatry Authors: at Tags: health Source Type: news

The duration of undiagnosed bipolar disorder: Effect on outcomes and treatment response
There are commonly long delays between the onset of bipolar disorder (BP), seeking of treatment and acquiring a bipolar disorder diagnosis. Whether a longer duration of undiagnosed bipolar disorder (DUBP) leads to an inferior treatment response is unclear in the literature. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 19, 2014 Category: Neurology Authors: Stacey McCraw, Gordon Parker, Rebecca Graham, Howe Synnott, P.B. Mitchell Source Type: research

Brain-derived neurotrophic factor (BDNF) – epigenetic regulation in unipolar and bipolar affective disorder
Alterations of brain-derived neurotrophic factor (BDNF) DNA methylation at specific BDNF promoters and corresponding gene expressions are associated with pathology and the response to antidepressant (AD) therapy in affective disorders such as major depressive disorder (MDD) and bipolar disorder (BD). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 19, 2014 Category: Neurology Authors: Laura Carlberg, Janine Scheibelreiter, Melanie R. Hassler, Monika Schloeglhofer, Michaela Schmoeger, Birgit Ludwig, Siegfried Kasper, Harald Aschauer, Gerda Egger, Alexandra Schosser Source Type: research

Experts urge new discipline combining benefits of neuroscience, psychology treatments
For some conditions, such as bipolar disorder, psychological treatments are not effective or are in their infancy. A 'culture gap' between neuroscientists and clinical scientists is hindering mental health treatment, say the life scientists, who call on scientists from both disciplines to work together to advance the understanding and treatment of psychological disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 18, 2014 Category: Science Source Type: news

Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.
Authors: Nickl-Jockschat T, Stöcker T, Krug A, Markov V, Maximov II, Huang R, Schneider F, Habel U, Eickhoff SB, Zerres K, Nöthen MM, Rietschel M, Jon Shah N, Treutlein J, Kircher T Abstract G72 (syn. DAOA, D-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. Diffusion tensor imaging studies hint at changes in fiber tract integrity in both disorders. We aimed to investigate whether a G72 susceptibility haplotype causes changes in fiber tract integrity in young healthy subjects. We compared fractional anisotropy in 47 subjects that were either homozygous for the M23...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 18, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Experts urge new discipline combining benefits of neuroscience and psychology treatments
(University of California - Los Angeles) For some conditions, such as bipolar disorder, psychological treatments are not effective or are in their infancy. A 'culture gap' between neuroscientists and clinical scientists is hindering mental health treatment, say the life scientists, who call on scientists from both disciplines to work together to advance the understanding and treatment of psychological disorders. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2014 Category: Global & Universal Source Type: news