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Agomelatine or placebo as adjunctive therapy to a mood stabiliser in bipolar I depression: randomised double-blind placebo-controlled trial.
Conclusions Agomelatine adjunctive therapy was not superior to placebo adjunctive therapy for acute bipolar depression. PMID: 25999335 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - May 23, 2015 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Taste Sensor Based on Lipid/Polymer Membrane Using Cascoded Compatible Lateral Bipolar Transistor
(Source: Sensor Letters)
Source: Sensor Letters - May 23, 2015 Category: Medical Equipment Authors: Jeong, Hyun-MinYun, Hyeon-JiKwon, Jin-BumKwon, Hyurk-ChoonKim, Sae-WanYoon, Na-RaeKim, Ju-SeongKang, Shin-Won Tags: Research Articles Source Type: research

Electroconvulsive Therapy–Induced Manic Episode for a Patient With Bipolar Depression: A Case Report
No abstract available (Source: The Journal of ECT)
Source: The Journal of ECT - May 23, 2015 Category: Psychiatry Tags: Letters to the Editor Source Type: research

Electroconvulsive Therapy and Its Association With Demographic and Clinical Characteristics in Chinese Psychiatric Patients
Conclusions: In a major psychiatric center in China, the use of ECT was much more common than the figures reported from most countries around the world. Reasons for this difference and variances in outcomes between settings with higher and lower ECT use should be studied. (Source: The Journal of ECT)
Source: The Journal of ECT - May 23, 2015 Category: Psychiatry Tags: Original Studies Source Type: research

The validity of the mood disorder questionnaire for screening bipolar disorder: a meta‐analysis
We conducted a meta‐analysis to review the diagnostic accuracy of the Mood Disorder Questionnaire (MDQ) among patients with mood disorders. We used a bivariate random effects model to calculate summary sensitivity and specificity. Twenty‐one studies were included. At the standard or modified cutoff value of 7, summary sensitivity was .62 and summary specificity was .85. When we pooled 11 studies including both patients with bipolar disorder (BD) and those with unipolar depression, the summary sensitivity was .76 and summary specificity was .81. However, among the six studies that excluded patients with known BD, the su...
Source: Depression and Anxiety - May 23, 2015 Category: Psychiatry Authors: Hee Ryung Wang, Young Sup Woo, Hyeong Sik Ahn, Il Min Ahn, Hyun Jung Kim, Won‐Myong Bahk Tags: Review Source Type: research

The association between biological rhythms, depression, and functioning in bipolar disorder: a large multi‐center study
ConclusionOur study shows a dose‐dependent association between the severity of depressive symptoms and degree of biological rhythms disturbance. Biological rhythms disturbance was also an independent predictor of functional impairment. Although the directionality of this relationship remains unknown, our results suggest that stability of biological rhythms should be an important target of acute and long‐term management of bipolar disorder and may aid in the improvement of functioning. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - May 23, 2015 Category: Psychiatry Authors: M. Pinho, M. Sehmbi, L. E. Cudney, M. Kauer‐Sant'anna, P. V. Magalhães, M. Reinares, C. M. Bonnín, R. B. Sassi, F. Kapczinski, F. Colom, E. Vieta, B. N. Frey, A. R Rosa Tags: Original Article Source Type: research

Effects of the jimpy mutation on mouse retinal structure and function
In conclusion, while the Jimpy mutation has dramatic effects on the myelination of retinal ganglion cell axons, it has moderate effects on retinal morphology and function. This article is protected by copyright. All rights reserved. Graphical Abstract Text In the Jimpy mutant mouse, axons in the CNS do not myelinate. The authors show that the lack of myelination in the optic nerve has surprisingly little consequences for retinal function. (Source: The Journal of Comparative Neurology)
Source: The Journal of Comparative Neurology - May 23, 2015 Category: Neurology Authors: Anahit Hovhannisyan, Boris Benkner, Antje Biesemeier, Ulrich Schraermeyer, Maria Kukley, Thomas A. Münch Tags: Research Article Source Type: research

Overmedicating Children in Foster Care
On any given day nearly one in four children in foster care is taking at least one psychotropic medication—more than four times the rate for all children. Nearly half of children living in residential treatment centers or group homes take psychotropic medications. Children in foster care are more likely to be prescribed multiple psychotropic medications at very high doses, although research shows higher doses can result in serious side effects. Viewers of the ABC News program 20/20 may remember Ke’onte Cook from a few years ago; he was a 10-year-old who had already spent four years in foster care being treated ...
Source: Healthy Living - The Huffington Post - May 22, 2015 Category: Consumer Health Advice Source Type: news

PCORI gives $120M for clinical research
The Patient-Centered Outcomes Research Institute has approved $120 million to fund 34 clinical comparative effectiveness research studies on a range of conditions and patient populations. The new awards include nearly $58.5 million to fund five pragmatic clinical studies that seek to answer important questions about radiation therapy for breast cancer, fractures in older adults, and treatments for children with bipolar disorder and Crohn's disease. Clinical read more (Source: Healthcare IT News)
Source: Healthcare IT News - May 22, 2015 Category: Information Technology Authors: Bernie Monegain Tags: Online Only Clinical Policy and Legislation Source Type: news

Toward Designing Efficient Multifunctional Bipolar Molecules: DFT Study of Hole and Electron Mobilities of 1,3,4-Oxadiazole Derivatives
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.5b04504 (Source: The Journal of Physical Chemistry C)
Source: The Journal of Physical Chemistry C - May 22, 2015 Category: Chemistry Authors: B. Priyanka, V. Anusha and K. Bhanuprakash Source Type: research

Problem Gambling and Homelessness: Results from an Epidemiologic Study
This study provides evidence that problem gambling is a significant public health issue among the African-American homeless population. Homeless services should include assessment for problem gambling along with psychiatric disorders and referrals to resources and treatment programs. Future studies should explore the relationship of the onset and course of problem gambling and other psychiatric disorders with homelessness as well as racial differences in gambling patterns and problem severity over time. (Source: Journal of Gambling Studies)
Source: Journal of Gambling Studies - May 22, 2015 Category: Addiction Source Type: research

Mood instability common to mental health disorders, associated with poor outcomes
Mood instability occurs in a wide range of mental disorders, and is not exclusive to affective conditions such as depression, bipolar disorder and anxiety disorder, new research confirms. The research also found that mood instability was associated with poorer clinical outcomes. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 22, 2015 Category: Science Source Type: news

Long-term effects of lithium on renal, thyroid, and parathyroid function: a retrospective analysis of laboratory data
Publication date: Available online 20 May 2015 Source:The Lancet Author(s): Brian Shine , Rebecca F McKnight , Laurence Leaver , John R Geddes Background Lithium is a widely used and highly effective treatment for mood disorders, but causes poorly characterised adverse effects in kidney and endocrine systems. We aimed to analyse laboratory information system data to determine the incidence of renal, thyroid, and parathyroid dysfunction associated with lithium use. Methods In a retrospective analysis of laboratory data from Oxford University Hospitals National Health Service Trust (Oxfordshire, UK), we investigated the i...
Source: The Lancet - May 22, 2015 Category: Journals (General) Source Type: research

Lithium therapy in bipolar disorder: a balancing act?
Publication date: Available online 20 May 2015 Source:The Lancet Author(s): Gin S Malhi (Source: The Lancet)
Source: The Lancet - May 22, 2015 Category: Journals (General) Source Type: research

Infrared Evaluation of The Heat-Sink Bipolar Diathermy Dissection Technique
This study examines the thermal effects of bipolar cautery upon the microvasculature and investigates the efficacy of heat sinking as a thermally protective technique in microsurgical dissection. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - May 22, 2015 Category: Cosmetic Surgery Authors: J. Allan, J. Dusseldorp, N.G. Rabey, C.M. Malata, D. Goltsman, A.F. Phoon Source Type: research

Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats.
Abstract Cecropia species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from Cecropia pachystachya leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content. Moreo...
Source: Neurochemical Research - May 22, 2015 Category: Neuroscience Authors: Gazal M, Kaufmann FN, Acosta BA, Oliveira PS, Valente MR, Ortmann CF, Sturbelle R, Lencina CL, Stefanello FM, Kaster MP, Reginatto FH, Ghisleni G Tags: Neurochem Res Source Type: research

A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline for Cocaine Dependence in Bipolar I Disorder.
CONCLUSIONS: Citicoline was well tolerated for treatment of cocaine dependence in patients with bipolar disorder. Cocaine use was significantly reduced with citicoline initially, although treatment effects diminished over time, suggesting the need for augmentation strategies to optimize long-term benefit. PMID: 25998279 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 22, 2015 Category: Psychiatry Authors: Brown ES, Todd JP, Hu LT, Schmitz JM, Carmody TJ, Nakamura A, Sunderajan P, Rush AJ, Adinoff B, Bret ME, Holmes T, Lo A Tags: Am J Psychiatry Source Type: research

Acute kidney injury, hyperbilirubinemia, and ischemic skin necrosis due to massive sulindac overdose.
We report the case of a 22-year old male with a history of bipolar disorder who was brought to the emergency department after ingesting approximately 15 g of sulindac in a suicide attempt. He was found to have acute kidney injury and hyperbilirubinemia. Despite aggressive fluid resuscitation, his renal function progressively worsened requiring the initiation of hemodialysis. Ten days following ingestion of sulindac, he began to develop ischemic skin changes with a gangrenous appearance in his hands and feet. He continued to receive supportive treatment, and his acute kidney injury, hyperbillirubinemia, and ischemic skin ne...
Source: Current Drug Safety - May 21, 2015 Category: Drugs & Pharmacology Authors: Vaughn JL, Shah KV, Ghossein MM, Meyer WL, Kirkpatrick RB Tags: Curr Drug Saf Source Type: research

One-of-a-kind star discovered, nicknamed 'Nasty'
Astronomers have spent decades trying to determine the oddball behavior of an aging star nicknamed "Nasty 1" residing in our Milky Way galaxy. Looking at the star using NASA's Hubble Space Telescope, astronomers had expected to see a bipolar outflow of twin lobes of gas from the star. The astronomers were surprised, however, to find a pancake-shaped disk of gas encircling the star. The vast disk is nearly 1,000 times the diameter of our solar system. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 21, 2015 Category: Science Source Type: news

Bipolar Disorder Recognized Earlier but Mortality Remains HighBipolar Disorder Recognized Earlier but Mortality Remains High
Bipolar disorder is being diagnosed at an earlier age, but there has been no significant decrease in BD-related mortality. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - May 21, 2015 Category: Psychiatry Tags: Psychiatry News Source Type: news

Genetic and genomic analyses as a basis for new diagnostic nosologies.
Authors: Gershon ES, Grennan KS Abstract For schizophrenia, bipolar disorder, and autism, clinical descriptions are precise and reliable, but there is great overlap among diagnoses in associated genetic polymorphisms and rare variants, treatment response, and other phenomenological findings such as brain imaging. It is widely hoped that new diagnostic categories can be developed which are more precise and predictive of important features of illness, particularly response to pharmacological agents. It is the intent of this paper to describe the diagnostic implications of some current genetic findings, and to describ...
Source: Dialogues in Clinical Neuroscience - May 21, 2015 Category: Neuroscience Tags: Dialogues Clin Neurosci Source Type: research

Homotopic reciprocal functional connectivity between anterior human insulae
This report demonstrates for the first time bi-directional homotopic and heterotopic functional connectivity between right and left anterior insulae. The short latency of the evoked responses suggests mono- or oligo-synaptic connections, most likely via the corpus callosum. (Source: Anatomy and Embryology)
Source: Anatomy and Embryology - May 21, 2015 Category: Anatomy Source Type: research

Fixed dose-combination products in psychiatry: Systematic review and meta-analysis
Despite highly prevalent use of drug combinations in psychiatry, combination products are not commonly available. We aimed to systematically review the evidence for the use and efficacy of combination products in the practice of psychiatry. Systematic search of major data bases yielded nine double-blind randomized controlled trials, which generated 15 comparisons of combination products against a single therapeutic agent, that included a placebo. All these studies included 2827 participants: 976 in their combination products arms and 1851 patients in the comparator arms. The number of combination products were identified, ...
Source: Journal of Psychopharmacology - May 21, 2015 Category: Psychiatry Authors: Farooq, S., Singh, S. P. Tags: Reviews Source Type: research

Reduced maternal levels of common viruses during pregnancy predict offspring psychosis: Potential role of enhanced maternal immune activity?
Viral infections during the prenatal or early childhood periods are one of the environmental factors which might play an etiological role in psychoses. Several studies report higher antibody levels against viruses during pregnancy in blood of mothers of offspring with psychotic disorders, but the presence of such viruses has never been demonstrated.The goal of this study was to investigate the potential association between viral infections during pregnancy and progeny with psychotic disorders and, for this purpose, we performed a nested case–control study involving pregnant mothers of offspring with schizophrenia or bipo...
Source: Schizophrenia Research - May 21, 2015 Category: Psychiatry Authors: Marta Canuti, Stephen Buka, Seyed Mohammad Jazaeri Farsani, Bas B. Oude Munnink, Maarten F. Jebbink, Nico J.M. van Beveren, Lieuwe de Haan, Jill Goldstein, Larry J. Seidman, Ming T. Tsuang, Jitschak G. Storosum, Lia van der Hoek Source Type: research

Mood instability is a common feature of mental health disorders and is associated with poor clinical outcomes
Conclusions Mood instability occurs in a wide range of mental disorders and is not limited to affective disorders. It is generally associated with relatively poor clinical outcomes. These findings suggest that clinicians should screen for mood instability across all common mental health disorders. The data also suggest that targeted interventions for mood instability may be useful in patients who do not have a formal affective disorder. (Source: BMJ Open)
Source: BMJ Open - May 21, 2015 Category: Journals (General) Authors: Patel, R., Lloyd, T., Jackson, R., Ball, M., Shetty, H., Broadbent, M., Geddes, J. R., Stewart, R., McGuire, P., Taylor, M. Tags: Open access, Health informatics, Mental health Research Source Type: research

Polygenic risk scores in bipolar disorder subgroups
This study aims at investigating whether a BD polygenic risk score (PGRS) can validate BD subtypes including diagnostic sub-categories (BD-I versus BD-II), patients with and without psychotic symptoms, polarity of first presenting episode and age at onset based groups. We also wanted to investigate whether illness severity indicators were associated with a higher polygenic risk for BD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - May 21, 2015 Category: Neurology Authors: Sofie Ragnhild Aminoff, Martin Tesli, Francesco Bettella, Monica Aas, Trine Vik Lagerberg, Srdjan Djurovic, Ole A Andreassen, Ingrid Melle Source Type: research

Homotopic reciprocal functional connectivity between anterior human insulae.
This report demonstrates for the first time bi-directional homotopic and heterotopic functional connectivity between right and left anterior insulae. The short latency of the evoked responses suggests mono- or oligo-synaptic connections, most likely via the corpus callosum. PMID: 25993901 [PubMed - as supplied by publisher] (Source: Brain Structure and Function)
Source: Brain Structure and Function - May 21, 2015 Category: Neuroscience Authors: Lacuey N, Zonjy B, Kahriman ES, Marashly A, Miller J, Lhatoo SD, Lüders HO Tags: Brain Struct Funct Source Type: research

Intraoperative functional mapping of calculation in parietal surgery. New insights and clinical implications
Conclusions Our findings support the specificity of the reported technique in the intraoperative identification of sites functional for calculation. Our data show the bilateral involvement of parietal cortex, especially of the inferior lobule, in calculation processing. Furthermore, our study suggests the existence of a sub-cortical pathway specific for calculation, whose better understanding might be crucial for the clinical outcome of patients. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - May 20, 2015 Category: Neurosurgery Source Type: research

Mood Disturbance in Adolescents Screened by the Mood Disorder Questionnaire Predicts Poorer Social Adjustment
Early-onset bipolar disorder is associated with a more severe illness course and poorer outcome. Its identification in adolescents may provide the opportunity for adequate intervention to improve global functioning and long-term prognosis. Thus, this study aimed to screen mood disturbance in a sample of high school students using Mood Disorder Questionnaire (MDQ) and follow up their adaptive functioning 1 year later. (Source: Journal of Adolescent Health)
Source: Journal of Adolescent Health - May 20, 2015 Category: Child Development Authors: Pei-Yin Pan, Chin-Bin Yeh Tags: Original article Source Type: research

Another Peek Behind the Curtain: How a Psychiatrist Diagnoses and Treats Bipolar Disorder
My previous article "How a Psychiatrist Treats Depression: A Peek Behind the Curtain" discusses the experience of seeing a psychiatrist for the first time. However, not every patient who comes to my office for an initial evaluation with depression has major depressive disorder. Some people suffering from depression may have (or think that they have) bipolar disorder. In brief, as a psychiatrist, when a new patient presents for evaluation and treatment, I always conduct a detailed patient interview to collect a thorough history. The patient will find that we have a wide ranging discussion. At times it will be open-ended ...
Source: Healthy Living - The Huffington Post - May 20, 2015 Category: Consumer Health Advice Source Type: news

No evidence for metabolic syndrome and lipid profile differences in patients suffering from bipolar I disorder with and without suicide attempts - Ahmadpanah M, Haghighi M, Jahangard L, Borzoei S, Heshmati S, Bajoghli H, Holsboer-Trachsler E, Brand S.
OBJECTIVES: The aim of the present study was to provide further evidence of 1) metabolic syndrome and blood lipids differences between suicide attempting and non-attempting patients with bipolar I disorder (BPD) and 2) as a function of acute depressive or ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 20, 2015 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Nature Or Nurture? The Long-Running Debate May Finally Be Settled
It's an age-old debate: do our genes make us who we are, or is it the environment in which we were raised? There's long been agreement that both "nature" and "nurture" play some role in determining many aspects of our physical and mental selves, from our height and weight to our intelligence and disposition. But as to which plays the bigger role in shaping us, scientists have never seemed to agree. That debate may now be over, thanks to a sweeping analysis of studies conducted around the world for more than five decades. The analysis -- involving more than 14.5 million twin pairs from 39 countries -- indicates that natu...
Source: Science - The Huffington Post - May 20, 2015 Category: Science Source Type: news

Cardiac perfusion imaging using hyperpolarized 13c urea using flow sensitizing gradients
ConclusionThe new pulse sequence was used to obtain dynamic images of the first passage of hyperpolarized 13C urea in the rodent heart, without contamination from bright signal within the neighboring cardiac lumen. This probe of myocardial perfusion is expected to enable new hyperpolarized 13C studies in which the cardiac metabolism/perfusion mismatch can be identified. Magn Reson Med, 2015. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attr...
Source: Magnetic Resonance in Medicine - May 20, 2015 Category: Radiology Authors: Angus Z. Lau, Jack J. Miller, Matthew D. Robson, Damian J. Tyler Tags: Full Paper Source Type: research

Patient-Important Outcomes in the Long-Term Treatment of Bipolar Disorder: A Mixed-Methods Approach Investigating Relative Preferences and a Proposed Taxonomy
Conclusions Patients’ preferences for outcomes in the long-term treatment of bipolar disorder vary considerably. To advance patient-centered healthcare, we propose that researchers, clinical guideline producers, and patient–clinician dyads integrate a taxonomy of patient-important outcomes, such as constructed in this study, when assessing treatment options. (Source: The Patient - Patient-Centered Outcomes Research)
Source: The Patient - Patient-Centered Outcomes Research - May 20, 2015 Category: Global & Universal Source Type: research

Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study
& Udo Dannlowski Keywords: (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - May 20, 2015 Category: Neurology Authors: Ronny RedlichKatharina DohmDominik GrotegerdNils OpelPienie ZwitserloodWalter HeindelVolker AroltHarald KugelUdo Dannlowski Source Type: research

Altered prefrontal cortex activity during working memory task in bipolar disorder: A functional magnetic resonance imaging study in euthymic bipolar I and II patients
Working memory (WM) deficits are among the most frequently impaired cognitive domains in patients with bipolar disorder (BD), being considered promising cognitive endophenotype of the disorder. However, the related neurobiological correlates still deserve further investigation. The present study was aimed to explore whether dorsolateral prefrontal cortex (DLPFC) activity during WM task was abnormal in euthymic bipolar patients and may represent a potential trait-related phenotype associated with the disorder. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - May 20, 2015 Category: Neurology Authors: Bernardo Dell’Osso, Claudia Cinnante, Annabella Di Giorgio, Laura Cremaschi, M. Carlotta Palazzo, Marta Cristoffanini, Leonardo Fazio, Cristina Dobrea, Sabrina Avignone, Fabio Triulzi, Alessandro Bertolino, A. Carlo Altamura Tags: Research report Source Type: research

Dıssocıatıon ın bıpolar dısorder: Relatıonshıps between clınıcal varıables and chıldhood trauma
The dissociative experiences of patients with bipolar disorder (BD) differ from those of patients with other psychiatric disorders with regard to certain features. The primary goal of this study was to evaluate the relationship between the clinical variables of BD and childhood trauma using the factor structure, psychometric features, and potential subdimensions of the Dissociative Experience Scale (DES). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - May 20, 2015 Category: Neurology Authors: Aytül Gursu Harırı, Medine Yazıcı Gulec, Fatma Fariha Cengız Orengul, Esra Aydın Sumbul, Rumeysa Yenı Elbay, Huseyin Gulec Source Type: research

Transcription factor SP4 phosphorylation Is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects
Transcription factors play important roles in the control of neuronal function in physiological and pathological conditions. We previously reported reduced levels of transcription factor SP4 protein, but not transcript, in the cerebellum in bipolar disorder and associated with more severe negative symptoms in schizophrenia. We have recently reported phosphorylation of Sp4 at S770, which is regulated by membrane depolarization and NMDA receptor activity. The aim of this study was to investigate SP4 S770 phosphorylation in bipolar disorder and its association with negative symptoms in schizophrenia, and to explore the potent...
Source: European Neuropsychopharmacology - May 20, 2015 Category: Psychiatry & Psychology Authors: Raquel Pinacho, Gregory Saia, J. Javier Meana, Grace Gill, Belén Ramos Source Type: research

Cardiac perfusion imaging using hyperpolarized (13) c urea using flow sensitizing gradients.
CONCLUSION: The new pulse sequence was used to obtain dynamic images of the first passage of hyperpolarized (13) C urea in the rodent heart, without contamination from bright signal within the neighboring cardiac lumen. This probe of myocardial perfusion is expected to enable new hyperpolarized (13) C studies in which the cardiac metabolism/perfusion mismatch can be identified. Magn Reson Med, 2015. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Comm...
Source: Magnetic Resonance in Medicine - May 20, 2015 Category: Radiology Authors: Lau AZ, Miller JJ, Robson MD, Tyler DJ Tags: Magn Reson Med Source Type: research

Global Day for Hope Kicks Off Mental Health Awareness Month
The International Foundation for Research and Education on Depression (iFred) launched its first annual Global Day for Hope on May 2, 2015, to support the 350 million people living with the treatable disease of depression. Organizations and individuals from around the globe joined together in solidarity to plant sunflowers, the international symbol of hope, in an effort to raise awareness and educate the public about treatment for depression. Through these efforts iFred aims to end the stigma around the disease that prevents so many people from seeking support. To date, plantings have taken place in Nepal, Germany, Sout...
Source: Healthy Living - The Huffington Post - May 19, 2015 Category: Consumer Health Advice Source Type: news

What types of neocortical GABAergic neurons do really exist?
Abstract The neocortex is regarded as the brain structure responsible for mediating higher brain functions, like conscious perception of sensory signals, learning and memory or programming of goal-directed behavior. Cortical circuits that enable these functions are formed by, first, a larger population of excitatory so-called principal cells (i.e., glutamatergic pyramidal cells; ca. 80–85 %), which issue long-distance projections, in addition to local recurrent collaterals, which form the major part of local cortical excitatory circuits. A second, smaller population of inhibitory also called local or short-axo...
Source: e-Neuroforum - May 19, 2015 Category: Neuroscience Source Type: research

The countertransference impact of autistic defence in an otherwise neurotic patient
This paper investigates the question of why, in the psychoanalytic psychotherapy of a patient with encapsulated autistic pathology, the steady maintenance of a therapeutically neutral stance can be especially difficult. Transference and countertransference vicissitudes are examined. The author notices that the patient's intolerance of ‘opposites’ (cf. Tustin, 1986), combined with extreme antipathy to having that intolerance noticed, can elicit corresponding, and potentially destabilizing, countertransference reactions. These reactions comprise an unstable tension between co‐existing pressures towards fusion with, or ...
Source: The International Journal of Psychoanalysis - May 19, 2015 Category: Psychiatry & Psychology Authors: Sylvia O'Neill Tags: Original Article Source Type: research

Endomyocardial biopsy-integrating electrode at the bioptome tip
Conclusions: Using existing technology, the 3DEAM, which integrates unipolar and bipolar signal from the bioptome tip, is feasible, and can be safely added to a standard echocardiographically guided endomyocardial biopsy. Future studies should investigate whether such a technique could increase the safety and diagnostic yield of endomyocardial biopsies in patients with suspected cardiomyopathies. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - May 19, 2015 Category: Cardiology Authors: Konecny, T., Noseworthy, P. A., Kapa, S., Cooper, L. T., Mulpuru, S. K., Sandhu, G. S., Asirvatham, S. Tags: Original Research Source Type: research

Valley detection using a graphene gradual pn junction with spin–orbit coupling: An analytical conductance calculation
Publication date: 4 September 2015 Source:Physics Letters A, Volume 379, Issues 30–31 Author(s): Mou Yang , Rui-Qiang Wang , Yan-Kui Bai Graphene pn junction is the brick to build up variety of graphene nano-structures. The analytical formula of the conductance of graphene gradual pn junctions in the whole bipolar region has been absent up to now. In this paper, we analytically calculated that pn conductance with the spin–orbit coupling and stagger potential taken into account. Our analytical expression indicates that the energy gap causes the conductance to drop a constant value with respect to that without gap in a...
Source: Physics Letters A - May 19, 2015 Category: Physics Source Type: research

Prevalence of psychiatric co-morbidity in treatment-seeking problem gamblers: A systematic review and meta-analysis
Conclusions: The findings highlight the need for gambling treatment services to undertake routine screening and assessment of psychiatric co-morbidity and provide treatment approaches that adequately manage these co-morbid disorders. Further research is required to explore the reasons for the variability observed in the prevalence estimates. (Source: Australian and New Zealand Journal of Psychiatry)
Source: Australian and New Zealand Journal of Psychiatry - May 19, 2015 Category: Psychiatry Authors: Dowling, N. A., Cowlishaw, S., Jackson, A. C., Merkouris, S. S., Francis, K. L., Christensen, D. R. Tags: Review Source Type: research

Making sense of DSM-5 mania with depressive features
Conclusion: A total of 27% of manic patients showed mixed features. Groups differed regarding clinical characteristics, course of illness, psychosocial functioning, prescribed treatment and symptom progress. Depressive symptoms in mania should be routinely assessed and considered to guide treatment. (Source: Australian and New Zealand Journal of Psychiatry)
Source: Australian and New Zealand Journal of Psychiatry - May 19, 2015 Category: Psychiatry Authors: Reinares, M., del Mar Bonnin, C., Hidalgo-Mazzei, D., Undurraga, J., Mur, M., Nieto, E., Saez, C., Vieta, E. Tags: Research Source Type: research

Eating behavior and obesity in bipolar disorder
Conclusions: These results suggest that disinhibition and perception of hunger may be linked to the disproportionately high rate of obesity in bipolar disorder. (Source: Australian and New Zealand Journal of Psychiatry)
Source: Australian and New Zealand Journal of Psychiatry - May 19, 2015 Category: Psychiatry Authors: Bernstein, E. E., Nierenberg, A. A., Deckersbach, T., Sylvia, L. G. Tags: Research Source Type: research

The clinical meaning of obsessive-compulsive symptoms in bipolar disorder and schizophrenia
(Source: Australian and New Zealand Journal of Psychiatry)
Source: Australian and New Zealand Journal of Psychiatry - May 19, 2015 Category: Psychiatry Authors: Tonna, M., Amerio, A., Ottoni, R., Paglia, F., Odone, A., Ossola, P., De Panfilis, C., Ghaemi, S. N., Marchesi, C. Tags: Letters Source Type: research

The Humors
For more than a thousand years, the humoral theory, derived from Aristotle and Galen, dominated medical and psychological thought. The body and mind were supposed to be ruled by four humors which, in equilibrium, brought perfect health; but the predominance of any one, whether from birth or age or circumstances, produced a certain type of physique and a cast of mind appropriate to certain activities and to a certain social status. The wrong humor in a given situation invited tragedy, for each humor belonged with certain stars and planets. The sanguine humor (blood) was under the astral influence of the planet Jupiter, and ...
Source: JAMA - May 19, 2015 Category: Journals (General) Source Type: research

Efficacy and tolerability of Treatments for bipolar depression
Depression in bipolar disorder is a major therapeutic challenge associated with disability and excess mortality. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - May 19, 2015 Category: Neurology Authors: Gustavo H Vázquez, Jessica N Holtzman, Leonardo Tondo, Ross J Baldessarini Source Type: research