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Antidepressants in Type II Versus Type I Bipolar Depression: A Randomized Discontinuation Trial
Conclusions: The findings do not confirm the hypothesis that long-term AD treatment in patients with BP-II has better outcomes than in patients with BD-I, except somewhat lower risk of manic/hypomanic episodes. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - September 1, 2015 Category: Psychiatry Tags: Brief Reports Source Type: research

Exploring Genetic Variability at PI, GSK3, HPA, and Glutamatergic Pathways in Lithium Response: Association With IMPA2, INPP1, and GSK3B Genes
Abstract: Lithium is considered the first-line treatment in bipolar disorder, although response could range from an excellent response to a complete lack of response. Response to lithium is a complex phenotype in which different factors, part of them genetics, are involved. In this sense, the aim of this study was to investigate the potential association of genetic variability at genes related to phosphoinositide, glycogen synthetase kinase-3 (GSK3), hypothalamic-pituitary-adrenal, and glutamatergic pathways with lithium response. A sample of 131 bipolar patients (99 type I, 32 type II) were grouped and compared according ...
Source: Journal of Clinical Psychopharmacology - September 1, 2015 Category: Psychiatry Tags: Brief Reports Source Type: research

Efficacy and Safety of Risperidone and Quetiapine in Adolescents With Bipolar II Disorder Comorbid With Conduct Disorder
Abstract: Although a frequent co-occurrence between bipolar disorder (BD) and conduct disorder (CD) in youth has been frequently reported, data about pharmacological management are scarce and focused on BD type I. Second generation antipsychotics are frequently used in clinical practice, but no comparative studies are available. The aim of this exploratory study was to compare efficacy and safety of risperidone and quetiapine in a sample of adolescents presenting a BD type II comorbid with CD. Twenty-two patients diagnosed with a structured interview according to Diagnostic and Statistical Manual of Mental Disorders, Fourt...
Source: Journal of Clinical Psychopharmacology - September 1, 2015 Category: Psychiatry Tags: Brief Reports Source Type: research

Asenapine in the Treatment of Acute Mania: A Real-World Observational Study With 6 Months Follow-Up
Abstract: Asenapine is a second-generation antipsychotic with a unique pharmacological profile that was recently approved for the treatment of moderate/severe manic episodes. Real-world data on rapidity of action in inpatient settings are lacking. The aims of the current real-world observational study were to evaluate: (i) short-term efficacy of asenapine after 7 days (T0-T1) in patients hospitalized for a manic episode in the course of bipolar I disorder or schizoaffective disorder (group A), (ii) differences in length of stay (LoS), and (iii) rehospitalization compared to a control population (group B) with a 6-month fol...
Source: Journal of Clinical Psychopharmacology - September 1, 2015 Category: Psychiatry Tags: Original Contributions Source Type: research

Higher-Order Motion-Compensation for In Vivo Cardiac Diffusion Tensor Imaging in Rats
This study presents diffusion-encoding schemes that are designed to compensate for higher-order motion components, including acceleration and jerk, which also have the desirable practical features of minimal TEs and high achievable b-values. The effectiveness of these schemes was verified numerically on a realistic beating heart phantom, and demonstrated empirically with in vivo cardiac diffusion MRI in rats. Compensation for acceleration, and lower motion components, was found to be both necessary and sufficient for obtaining diffusion-weighted images of acceptable quality and SNR, which yielded the first in vivo cardiac ...
Source: IEE Transactions on Medical Imaging - September 1, 2015 Category: Biomedical Engineering Source Type: research

Child & Adolescent Mental Health: A Practical, All-in-One Guide
About twenty percent of children and adolescents in the United States — that’s roughly fifteen million kids — have a diagnosable mental health condition. Odds are, you know one, or have one, yourself: a child who struggles to control their emotions and behaviors, or has a hard time in school or relating to others. Whatever happened to our free-spirited, happy, socially adjusted, emotionally stable children and adolescents, you might ask. They still exist. But it’s a widely accepted fact in psychiatry and clinical psychotherapy that children and adolescents are dealing with an increased number of educational, socia...
Source: Psych Central - August 31, 2015 Category: Psychiatry Authors: Tamara Hill, MS Tags: Book Reviews Children and Teens Disorders Family General Parenting Professional Psychiatry Psychological Assessment Psychology Psychotherapy School Issues Students a practical all in one guide Child & Adolescent Mental Health Source Type: news

Distinct trafficking of cell surface and endosomal TIM‐1 to the immune synapse
Abstract The T cell/transmembrane, mucin and immunoglobulin domain protein 1 (TIM‐1) is a phosphatidlyserine (PtdSer) receptor and a T cell costimulatory molecule linked to the development of atopic diseases. TIM‐1 locates preferentially in intracellular compartments. Here we show that in human and mouse lymphoid cells, TIM‐1 localizes in different types of endosomes and that its domain structure is important for protein sorting to intracellular vesicles. The BALB/c mouse TIM‐1 protein, which has a longer mucin domain, is sorted more efficiently to endosomes than the shorter C57BL/6 variant. High affinity ligands s...
Source: Traffic - August 31, 2015 Category: Research Authors: Meriem Echbarthi, Manuela Zonca, Rachel Mellwig, Yannick Schwab, Gerardo G. Kaplan, Rosemarie H. DeKruyff, Pedro Roda‐Navarro, Jose M. Casasnovas Tags: Original Article Source Type: research

Learn More About Neurologist Oliver Sacks' Greatest Works
(Reuters) - Oliver Sacks, the neurologist who studied the intricacies of the brain and wrote eloquently about them in books such as "Awakenings" and "The Man Who Mistook His Wife for a Hat," died on Sunday at the age of 82, his personal assistant said. The British-born Sacks, who announced in February that he had terminal liver cancer, died at his home in New York City at 1:30 a.m. with his partner, the writer Billy Hayes, and his personal assistant, Kate Edgar, at his side, Edgar told Reuters. "He definitely wrote to the very end," said Edgar, noting Sacks in his final days never stopped penning a legacy that will be publ...
Source: Science - The Huffington Post - August 31, 2015 Category: Science Source Type: news

An Investigation into the Effects of Different Types of Exercise on the Maintenance of Approach Motivation Levels
Conclusions These results provide a first step in investigating the possible risks associated with engaging in different intensities of exercise during a hypomanic episode. Any recommendations within this study should however be taken in light of the limitations identified. Further research replicating these results with a larger sample and among individuals with Bipolar Disorder is recommended. (Source: Mental Health and Physical Activity)
Source: Mental Health and Physical Activity - August 31, 2015 Category: Psychiatry & Psychology Source Type: research

Maurice Benard - Spokesman For Bipolar Disorder
Maurice Benard, from General Hospital, has spoken openly about having bipolar disorder and acts as a spokesman for two major mental health organizations. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - August 31, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Ribosomal DNA transcription in dorsal raphe nucleus neurons is increased in residual schizophrenia compared to depressed patients with affective disorders
The central serotonergic system is implicated differentially in the pathogenesis of depression and schizophrenia. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in both disorders. The study was carried out on paraffin-embedded brains from 27 depressed (15 major depressive disorder, MDD and 12 bipolar disorder, BD) and 17 schizophrenia (9 residual and 8 paranoid) patients and 28 matched controls without mental disorders. The transcriptional activity of ribosomal DNA (rDNA) in DRN neurons was evaluated by the AgNOR silver staining method. (Source: Psychiatry Research)
Source: Psychiatry Research - August 31, 2015 Category: Psychiatry Authors: Marta Krzyżanowska, Johann Steiner, Ralf Brisch, Christian Mawrin, Stefan Busse, Katharina Braun, Zbigniew Jankowski, Hans-Gert Bernstein, Bernhard Bogerts, Tomasz Gos Source Type: research

Social functioning as a predictor of the use of mental health resources in patients with severe mental disorder
This study aims to assess the effect of social functioning on mental health service use in a sample of patients with severe mental disorder (schizophrenia, other psychotic disorders or bipolar affective disorder) in an area of Spain. (Source: Psychiatry Research)
Source: Psychiatry Research - August 31, 2015 Category: Psychiatry Authors: Gloria Bellido-Zanin, Maria Ángeles Perez-San-Gregorio, Agustin Martin-Rodriguez, Antonio J Vázquez-Morejón Source Type: research

Bipolar Disorder: Functional Neuroimaging Markers in Relatives
We reported and summarized all functional magnetic resonance imaging (fMRI) studies focusing on first-degree relatives of BD patients. We found 29 studies reporting neural correlates of working memory (WM), emotional processing, executive functions and resting state in relatives of BD patients, compared to healthy subjects. Overall, the same regions that have been involved in patients, such as the inferior frontal gyrus and limbic areas, seem to be functionally altered in high-risk subjects. We conclude that the same brain regions already implicated in the pathophysiology of the disease such as the amygdala are also associ...
Source: Neuroscience and Biobehavioral Reviews - August 30, 2015 Category: Neuroscience Source Type: research

Spontaneous dissociation of bipolar hip hemiarthroplasty in a patient with nerve palsy: A case report and review of the literature
CONCLUSION To prevent this condition, preoperative planning and proper techniques should be done as an index procedure. In the case of marked shortening of the limb after an operation in patients with lower limb muscle weakness, we hypothesize that early full weight bearing with immediate use of a shoe lift might help prevent this condition. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - August 30, 2015 Category: Surgery Source Type: research

Association of arterial hypertension and cognitive impairment in euthymic bipolar disorder.
CONCLUSION: Despite relatively small sample size, noticeable association of hypertension and cognitive impairment was revealed. This might indicate possible way of enhancing cognition in bipolar disorder by treating elevated blood pressure. PMID: 26313398 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - August 29, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Single Use Energy Sources and Operating Room Time for Laparoscopic Hysterectomy: a Randomized Controlled Trial
Conclusion A single use energy device that both desiccates and cuts significantly reduced operating room time to justify its own cost and reduced total intraoperative direct costs during laparoscopic hysterectomy in our institution. It is notable that operating room cost per minute varies between institutions and must be considered before generalizing our results. Teaser A single use energy device that both desiccates and cuts significantly reduced operating room time to justify its own cost and reduced total intraoperative direct costs during laparoscopic hysterectomy. (Source: Journal of Minimally Invasive Gynecology)
Source: Journal of Minimally Invasive Gynecology - August 29, 2015 Category: OBGYN Source Type: research

Increases in multiple psychiatric disorders in parents and grandparents of patients with bipolar disorder from the USA compared with The Netherlands and Germany
Conclusion: The increased complexity of psychiatric illness and its occurrence over several generations in the families of patients with bipolar disorder from the USA versus Europe could be contributing to the higher incidence of childhood onsets and greater virulence of illness in the USA compared with Europe. These data are convergent with others suggesting increased both genetic and environmental risk in the USA, but require replication in epidemiologically-derived populations with data based on interviews of the family members. (Source: Psychiatric Genetics)
Source: Psychiatric Genetics - August 28, 2015 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research

The association between childhood trauma and facial emotion recognition in adults with bipolar disorder - Russo M, Mahon K, Shanahan M, Solon C, Ramjas E, Turpin J, E Burdick K.
Many patients with bipolar disorder (BD) have difficulties in facial emotion recognition, which may also be impaired in maltreated children and in subjects who have a positive history of childhood traumatic experiences. Childhood trauma is reported with a ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 28, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Schizophrenia and bipolar disorder: The road from similarities and clinical heterogeneity to neurobiological types
Publication date: 20 September 2015 Source:Clinica Chimica Acta, Volume 449 Author(s): Claudia Dacquino, Pietro De Rossi, Gianfranco Spalletta Although diagnosis is a central issue in medical care, in psychiatry its value is still controversial. The function of diagnosis is to indicate treatments and to help clinicians take better care of patients. The fundamental role of diagnosis is to predict outcome and prognosis. To date serious concern persists regarding the clinical utility and predictive validity of the diagnosis system in psychiatry, which is at the most syndromal. Schizophrenia and bipolar disorder, which no...
Source: Clinica Chimica Acta - August 28, 2015 Category: Laboratory Medicine Source Type: research

Comparison of bipolar hemiarthroplasty and total hip arthroplasty for displaced femoral neck fractures in the healthy elderly: a meta-analysis
Conclusions: For healthy elderly patients with displaced FNFs, treatment with BHA led to better outcomes regarding dislocation rate, while THA was better regarding acetabular erosion rate and reoperation rate. When comparing BHA with THA, there were no significant differences in other important outcomes such as Harris Hip Score, infection rate, general complications, and 1-year mortality. Further high-quality RCTs are needed to provide robust evidence and evaluate the treatment options. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - August 28, 2015 Category: Orthopaedics Authors: Feng WangHaifei ZhangZhiyu ZhangChengbin MaXimin Feng Source Type: research

Hubble Telescope Spies A Cosmic 'Butterfly'
Who knew that there are "butterflies" in deep space? A new image taken by the Hubble Space Telescope shows the bipolar planetary nebula PN M2-9, known as the Twin Jet Nebula, in all of its glory -- and the cosmic beauty appears butterfly-like in shape and color. The Twin Jet Nebula was first discovered by German-American astronomer Rudolph Minkowski (1895-1976) in 1947. While a previous image of the brilliant nebula was released in 1997, this latest image incorporates more recent observations. (Story continues below.) A ground-based view of the night sky, before zooming in on the Twin Jet Neb...
Source: Science - The Huffington Post - August 27, 2015 Category: Science Source Type: news

Is our desire for genetic answers cultural rather than scientific?
Genes and the Bioimaginary, by Professor Deborah Lynn Steinberg, investigates whether the foundations of much genetic research are scientifically soundThe last few decades have seen what some describe as a “genetic revolution”. Advances in genetic science have seen genes become all-encompassing in political and scientific discussion.Do a quick survey of recent stories, for example, and you will find research that claims “intelligence, creativity and bipolar disorder may share underlying genetics” and a much-reported story that found that Holocaust survivors may have passed ontrauma to their children through their g...
Source: Guardian Unlimited Science - August 27, 2015 Category: Science Authors: Simon Copland Tags: Genetics Science Biology Books Source Type: news

Internet-based psychological interventions for bipolar disorder: Review of the present and insights into the future
In the last decade, there has been an increasing advent of innovative concepts in psychological interventions aimed at empowering bipolar patients by means of technological advancements and taking advantage of the proliferation of the Internet. Since the adoption of these technologies for behavioral monitoring and intervention is not trivial in clinical practice, the main objective of this review is to provide an overview and to discuss the several initiatives published so far in the literature related to the Internet-based technologies aimed to deliver evidence-based psychological interventions for bipolar disorder patien...
Source: Journal of Affective Disorders - August 27, 2015 Category: Neurology Authors: Diego Hidalgo-Mazzei, Ainoa Mateu, María Reinares, Aleksandar Matic, Eduard Vieta, Francesc Colom Source Type: research

Facial recognition deficits as a potential endophenotype in bipolar disorder
Bipolar disorder (BD) is considered a highly heritable and genetically complex disorder. Several cognitive functions, such as executive functions and verbal memory have been suggested as promising candidates for endophenotypes. Although there is evidence for deficits in facial emotion recognition in individuals with BD, studies investigating these functions as endophenotypes are rare. The current study investigates emotion recognition as a potential endophenotype in BD by comparing 36 BD participants, 24 of their 1st degree relatives and 40 healthy control participants in a computerised facial emotion recognition task. (So...
Source: Psychiatry Research - August 27, 2015 Category: Psychiatry Authors: Esther Vierck, Richard J. Porter, Peter R. Joyce Source Type: research

Side effects limit acute efficacy of unilateral unipolar electrical carotid sinus stimulation in patients with treatment resistant arterial hypertension
Electrical carotid sinus stimulation is a treatment modality in resistant arterial hypertension. The first generation device (Rheos™) relying on bilateral placement of bipolar electrodes acutely reduced muscle sympathetic nerve activity (MSNA) and blood pressure (BP) but is no longer available. The second-generation device (Neo™) utilizes a small unilateral unipolar disk electrode to reduce invasiveness while saving battery life. We tested acute effects of the latter on BP and MSNA. We studied 18 patients (9 women, 53±11years, 34±5kg/m2) with refractory hypertension on stable medication who had been implanted with th...
Source: Autonomic Neuroscience: Basic and Clinical - August 26, 2015 Category: Neuroscience Authors: K Heusser, J. Brinkmann, J. Menne, J. Kaufeld, S. Linnenweber-Held, M. Wilhelmi, A. Diedrich, H. Haller, J. Jordan, J. Tank Tags: 17.4 Source Type: research

Suicide risk after nonfatal self-harm: a national cohort study, 2000-2008.
CONCLUSION: Individuals with severe mental disorders (affective and psychotic disorders) have a poor prognosis in the first years after hospital admission due to self-harm. The risk of subsequent suicide is higher after attempts by hanging and other self-injury methods (vs self-poisoning). Aftercare for those with a self-harm episode should focus on treatment of the mental disorder present at the time of the episode. PMID: 26301588 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 26, 2015 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Robotic right colectomy with intracorporeal anastomosis: Video Vignette
This article is protected by copyright. All rights reserved. (Source: Colorectal Disease)
Source: Colorectal Disease - August 26, 2015 Category: Gastroenterology Authors: Samson Tou, Andrew Duncan, Simona Giuratrabocchetta, Roberto Bergamaschi Tags: Correspondence Source Type: research

Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder
Conclusion: This analysis identified a lower estimated suicide rate in bipolar disorder than what was previously published. Understanding the overall risk of suicide deaths and attempts, and the most common methods, are important building blocks to greater awareness and improved interventions for suicide prevention in bipolar disorder. Replication of genetic findings and stronger prospective data on treatment options are required before more decisive conclusions can be made regarding the neurobiology and specific treatment of suicide risk in bipolar disorder. (Source: Australian and New Zealand Journal of Psychiatry)
Source: Australian and New Zealand Journal of Psychiatry - August 26, 2015 Category: Psychiatry Authors: Schaffer, A., Isometsa, E. T., Tondo, L., Moreno, D. H., Sinyor, M., Kessing, L. V., Turecki, G., Weizman, A., Azorin, J.-M., Ha, K., Reis, C., Cassidy, F., Goldstein, T., Rihmer, Z., Beautrais, A., Chou, Y.-H., Diazgranados, N., Levitt, A. J., Zarate, C. Tags: Review Source Type: research

Functioning in bipolar disorder with substance abuse/dependence in a community sample of young adults
To assess the functional impairment of young adults with bipolar disorder with substance abuse/dependence comorbidity. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 26, 2015 Category: Neurology Authors: Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Pedro V S Magalhães, Flavio Kapczinski, Karen Jansen Source Type: research

Safety and efficacy of bipolar versus monopolar transurethral resection of the prostate in patients with large prostates or severe lower urinary tract symptoms: Post hoc analysis of a European multicenter randomized controlled trial
To compare B-TURP vs. M-TURP safety/secondary outcomes including efficacy in patients with large PV or severe LUTS. (Source: The Journal of Urology)
Source: The Journal of Urology - August 26, 2015 Category: Urology & Nephrology Authors: A. Skolarikos, J. Rassweiler, J.J. de la Rosette, G. Alivizatos, C. Scoffone, R.M. Scarpa, M. Schulze, C. Mamoulakis Source Type: research

A Preliminary Observation of Increased Glial Cell Line-Derived Neurotrophic Factor in Manic Switch due to Electroconvulsive Treatment in Depressive Patients
Conclusions: Our data suggest the role of GDNF in manic switch and the involvement of glial system in the pathogenesis of mood disorders. (Source: The Journal of ECT)
Source: The Journal of ECT - August 25, 2015 Category: Psychiatry Tags: Original Studies Source Type: research

The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia
CONCLUSION: Together, the results of this study suggest that the DISC1 translocation may increase the risk of psychiatric disorders in this pedigree by affecting neurostructural phenotypes such as cortical thickness.FUNDING: This work was supported by the National Health Service Research Scotland, the Scottish Translational Medicine Research Collaboration, the Innovative Medicines Initiative (IMI), the Engineering and Physical Sciences Research Council (EPSRC), The Wellcome Trust, the National Institute of Health Research (NIHR), and Pfizer. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - August 25, 2015 Category: Biomedical Science Authors: Orla M. Doyle, Catherine Bois, Pippa Thomson, Liana Romaniuk, Brandon Whitcher, Steven C.R. Williams, Federico E. Turkheimer, Hreinn Stefansson, Andrew M. McIntosh, Mitul A. Mehta, Stephen M. Lawrie Source Type: research

Olanzapine Is Faster than Haloperidol in Inducing Metabolic Abnormalities in Schizophrenic and Bipolar Patients
The effects of olanzapine and haloperidol on metabolic parameters in bipolar patients have been evaluated much less comprehensively than in schizophrenic patients. Therefore, in this study, medical records of 343 schizophrenic and bipolar patients treated with haloperidol or olanzapine for 1 year were retrospectively reviewed and metabolic outcomes were evaluated. After 12 months of follow-up, 25.9% of patients showed ≥3 metabolic abnormalities with a point prevalence of 27.2% in the bipolar and 24.9% in the schizophrenic group: 22.0% of the schizophrenic patients treated with haloperidol and 29.8% of those treated with ...
Source: Neuropsychobiology - August 25, 2015 Category: Psychiatry & Psychology Source Type: research

Simultaneous removal of hexavalent chromium and COD from industrial wastewater by bipolar electrocoagulation
Publication date: Available online 24 August 2015 Source:Chemical Engineering and Processing: Process Intensification Author(s): Karima Cheballah, Amar Sahmoune, Karima Messaoudi, Nadjib Drouiche, Hakim Lounici The purpose of this study is to remove hexavalent chromium and COD from wastewater by electrocoagulation. The experiments were carried out in an electrochemical reactor using iron sacrificial electrode. Operating parameters such as current density (100, 150, 200A/m2), pH of the effluent, number of electrodes and their materials were studied. The optimal operating conditions were determined and applied to the ...
Source: Chemical Engineering and Processing: Process Intensification - August 25, 2015 Category: Chemistry Source Type: research

Treatment Resistant Schizophrenia is associated to the worst community functioning among severely-ill highly-disabling psychiatric conditions and is the most relevant predictor of poorer achievements in functional milestones
Publication date: Available online 25 August 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Felice Iasevoli, Sara Giordano, Raffaele Balletta, Gianmarco Latte, Maria Vittoria Formato, Emiliano Prinzivalli, Domenico De Berardis, Carmine Tomasetti, Andrea de Bartolomeis The aim of this work was to compare achievements in milestones of community functioning in highly disabling psychiatric conditions, including Treatment Resistant Schizophrenia (TRS), schizophrenia (responsive to antipsychotics), bipolar disorder, anxiety/depressive diseases. Also, we investigated the predictor...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 25, 2015 Category: Psychiatry Source Type: research

The relationship between sleep quality and neurocognition in bipolar disorder
We examined the association between sleep dysfunction and neurocognition in BD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 25, 2015 Category: Neurology Authors: Manuela Russo, Katie Mahon, Megan Shanahan, Elizabeth Ramjas, Carly Solon, Shaun M Purcell, Katherine E Burdick Source Type: research

Corrigendum to: Antidepressants worsen rapid-cycling course in bipolar disorder: A STEP-BD randomized clinical trial. J. Affect. Disord. (Jun. 10, 2015); http://dx.doi.org/10.1016/j.jad.2015.04.054
The ratio of 2.93 times more depressive episodes in rapid cyclers versus non-rapid cyclers continued on antidepressants was presented as 293% instead of 193%, as it should be. So too with the ratio of 2.68 times more overall mood episodes in rapid cyclers versus non-rapid cyclers continued on antidepressants, which should have been converted to 168% increase, not 268%. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 25, 2015 Category: Neurology Authors: RS El-mallakh, PA Vohringer, MM Ostacher, CF Baldassano, NS Holtzman, EA Whitham, SB Thommi, FK Goodwin, SN Ghaemi Source Type: research

Elevated serum immunoinflammation-related protein complexes are associated with psychosis
Emerging evidence suggests an underlying immune and inflammatory response for a variety of psychiatric disorders. Herein, we employed an optimized native-polyacrylamide gel electrophoresis to isolate psychosis-related serum immunoinflamation-related protein complexes (IIRPCs) from 147 patients with schizophrenia (SCH), 158 patients with bipolar disorder (BPD), 132 patients with other psychosis group, and 145 normal controls. All participants could be classified into four categories based on serum IIRPCs, which correspond to 290, 215, 70, and 7 serum samples, respectively. (Source: Psychiatry Research)
Source: Psychiatry Research - August 25, 2015 Category: Psychiatry Authors: Yujie Liu, Dan Zhang, Yuhang Cheng, Zhili Li Source Type: research

Alzheimer´s Disease associated with Psychiatric Comorbidities.
Abstract Alzheimer's disease (AD) is the most common cause of dementia and has become a severe public health issue. It is estimated that globally, 35.6% of people have some form of dementia. This number is expected to double by 2030, and possibly even triple by 2050. The disease is associated with deficits in cognition/memory and a reduced ability in coping with everyday life. Moreover, patients can experience behavioral alterations such as mood swings, depression and hallucinations. Therefore, it is common to find the presence of neuropsychiatric comorbidities such as depression, schizophrenia and bipolar disorder...
Source: An Acad Bras Cienc - August 25, 2015 Category: Science Authors: Garcez ML, Falchetti AC, Mina F, Budni J Tags: An Acad Bras Cienc Source Type: research

“Button Type” Bipolar Plasma Vaporization of the Prostate Compared with Standard Transurethral Resection: A Systematic Review and Meta‐Analysis of short‐term outcome studies
ConclusionButton‐Type plasma vaporisation is an efficient and safe treatment of BPH. The improvement of urinary symptoms and overall complications are comparable to conventional TURP. However, BTVP appears to be associated with a lower rate of major complications.This article is protected by copyright. All rights reserved. (Source: BJU International)
Source: BJU International - August 24, 2015 Category: Urology & Nephrology Authors: Marcelo Langer Wroclawski, Arie Carneiro, Rodrigo Dal Moro Amarante, Carlos Eduardo Bonafe Oliveira, Victor Shimanoe, Bianca Alves Vieira Bianco, Paulo Kouiti Sakuramoto, Antonio Carlos Lima Pompeo Tags: Original Article Source Type: research

Multimodal responses induced by cortical stimulation of the parietal lobe: a stereo-electroencephalography study
The functional complexity of the parietal lobe still represents a challenge for neurophysiological and functional neuroimaging studies. While the somatosensory functions of the anterior parietal cortex are well established, the posterior parietal cortex has a relevant role in processing the sensory information, including visuo-spatial perception, visual attention, visuo-motor transformations and other complex and not completely understood functions. We retrospectively analysed all the clinical manifestations induced by intracerebral bipolar electrical stimulation in 172 patients suffering from drug-resistant focal epilepsy...
Source: Brain - August 24, 2015 Category: Neurology Authors: Balestrini, S., Francione, S., Mai, R., Castana, L., Casaceli, G., Marino, D., Provinciali, L., Cardinale, F., Tassi, L. Tags: Epilepsy and Sleep Original Articles Source Type: research

Altered amygdala-prefrontal response to facial emotion in offspring of parents with bipolar disorder
This study aimed to identify neuroimaging measures associated with risk for, or protection against, bipolar disorder by comparing youth offspring of parents with bipolar disorder versus youth offspring of non-bipolar parents versus offspring of healthy parents in (i) the magnitude of activation within emotional face processing circuitry; and (ii) functional connectivity between this circuitry and frontal emotion regulation regions. The study was conducted at the University of Pittsburgh Medical Centre. Participants included 29 offspring of parents with bipolar disorder (mean age = 13.8 years; 14 females), 29 offspring of n...
Source: Brain - August 24, 2015 Category: Neurology Authors: Manelis, A., Ladouceur, C. D., Graur, S., Monk, K., Bonar, L. K., Hickey, M. B., Dwojak, A. C., Axelson, D., Goldstein, B. I., Goldstein, T. R., Bebko, G., Bertocci, M. A., Hafeman, D. M., Gill, M. K., Birmaher, B., Phillips, M. L. Tags: Neuropsychiatry Original Articles Source Type: research

Epilepsy and bipolar disorder.
Abstract It is well recognized that mood disorders and epilepsy commonly co-occur. Despite this, our knowledge regarding the relationship between epilepsy and bipolar disorder is limited. Several shared features between the two disorders, such as their episodic nature and potential to run a chronic course, and the efficacy of some antiepileptic medications in the prophylaxis of both disorders, are often cited as evidence of possible shared underlying pathophysiology. The present paper aims to review the bidirectional associations between epilepsy and bipolar disorder, with a focus on epidemiological links, evidence...
Source: Epilepsy and Behaviour - August 24, 2015 Category: Neurology Authors: Knott S, Forty L, Craddock N, Thomas RH Tags: Epilepsy Behav Source Type: research

Prevalence and risk factors for intra-operative periprosthetic fractures in one thousand eight hundred and seventy two patients undergoing total hip arthroplasty: a cross-sectional study
Conclusions Intraoperative periprosthetic fracture is a rare event, and it is associated with revision type surgery and THA in a previously operated hip. (Source: International Orthopaedics)
Source: International Orthopaedics - August 23, 2015 Category: Orthopaedics Source Type: research

Impact of lithium alone or in combination with haloperidol on oxidative stress parameters and cell viability in SH-SY5Y cell culture.
CONCLUSIONS: The results of our study may indicate that lithium possess neuroprotective properties that may be partly due to antioxidative effects. The combination of lithium and haloperidol may generate increased oxidative stress. PMID: 26286703 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - August 22, 2015 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

A group ICA based framework for evaluating resting fMRI markers when disease categories are unclear: application to schizophrenia, bipolar, and schizoaffective disorders
This study is aimed to explore biomarkers from resting-state fMRI networks for differentiating these disorders and investigate the relationship among these disorders based on fMRI networks with an emphasis on SAD. Firstly, a novel group ICA method, group information guided independent component analysis (GIG-ICA), was applied to extract subject-specific brain networks from fMRI data of 20 healthy controls (HC), 20 SZ patients, 20 BP patients, 20 patients suffering from SAD with manic episodes (SADM), and 13 patients suffering from SAD with depressive episodes exclusively (SADD). Then, five-level one-way analysis of covaria...
Source: NeuroImage - August 22, 2015 Category: Neuroscience Source Type: research

Symptom severity of bipolar disorder during the menopausal transition
Conclusions: These results support the theory that times of increased reproductive hormonal changes, such as the late MT and early postmenopause, here compared to early MT, are associated with greater mood symptom severity in bipolar spectrum women. Nonetheless, absolute or change in FSH and estradiol levels were not significantly associated with depression or mood elevation severity. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - August 22, 2015 Category: Psychiatry Authors: Wendy MarshBernice GershensonAnthony Rothschild Source Type: research

Optical magnification devices in tonsillectomy: a prospective randomised clinical study
Abstract Tonsillectomy is one of the most common surgical procedure in otorhinolaryngology. A plethora of approaches has been undertaken so far to limit postoperative pain, one of the major problems patients are concerned with. Thermal damages of the surrounding tissue caused by coagulation during surgery are discussed to correlate with postoperative pain. Therefore, we studied whether the use of magnification devices reduced coagulation procedures and consequently limited post-operative pain. Following an intraindividual design, we performed tonsillectomy on one side using a microscope or magnifying glasses wher...
Source: European Archives of Oto-Rhino-Laryngology - August 21, 2015 Category: ENT & OMF Source Type: research

Severe Darier's disease in a psychiatric patient
We report a case of Darier’s disease in a 48-year-old female patient presenting severe cutaneous and psychiatric manifestations. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - August 21, 2015 Category: Dermatology Source Type: research

Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models Rodent and human studies
Publication date: Available online 19 August 2015 Source:Neuroscience & Biobehavioral Reviews Author(s): Jordy van Enkhuizen, Mark A. Geyer, Arpi Minassian, William Perry, Brook L. Henry, Jared W. Young Psychiatric patients with bipolar disorder suffer from states of depression and mania, during which a variety of symptoms are present. Current treatments are limited and neurocognitive deficits in particular often remain untreated. Targeted therapies based on the biological mechanisms of bipolar disorder could fill this gap and benefit patients and their families. Developing targeted therapies would benefit ...
Source: Neuroscience and Biobehavioral Reviews - August 21, 2015 Category: Neuroscience Source Type: research