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Circadian abnormalities as markers of susceptibility in bipolar disorders.
Authors: Milhiet V, Boudebesse C, Bellivier F, Drouot X, Henry C, Leboyer M, Etain B Abstract Chronobiological models have contributed to a better understanding of the pathophysiology of bipolar disorders. Circadian functions dysregulations are associated with bipolar disorders, including biochemical (melatonin and cortisol profiles), actigraphic (sleep/wake patterns), and dimensional (chronotypes) circadian markers. These associations are observed not only during acute episodes but also during euthymic periods. Most markers that are associated with bipolar disorders are also found in the healthy relatives of patie...
Source: Frontiers in Bioscience - Scholar - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research

Can the response to mood stabilizers be predicted in bipolar disorder?
Authors: Geoffroy PA, Bellivier F, Leboyer M, Etain B Abstract Bipolar disorder (BD) is a severe chronic multifactorial disease that requires maintenance therapy with mood stabilizers (MS). Even with medications, the rate of response among patients with BD is low and the risk of relapse is high. Therefore, in this context of the urgent need for reliable and reproducible predictors of individual responses to MS, pharmacogenetics research is expected to provide helpful progress. Most pharmacogenetic studies of MS have focused on the response to lithium with several good putative candidate genes but informative result...
Source: Frontiers in Bioscience - Elite - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Neurocognitive performance as an endophenotype for bipolar disorder.
Authors: Raust A, Daban C, Cochet B, Henry C, Bellivier F, Scott J Abstract Identification of the underlying liability to develop bipolar disorders (BD) is hindered by the genetic complexity and phenotypic heterogeneity of the disease. The use of endophenotypes has been acknowledged as a promising approach that may detect the hidden manifestations of a genetic liability for an illness. One of the most commonly proposed endophenotypes in BD is neurocognitive performance. We identified and examined previously published review articles that had any data pertaining to endophenotypes in BD and combined this with an exte...
Source: Frontiers in Bioscience - Elite - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Biomarkers of bipolar disorder: specific or shared with schizophrenia?
Authors: Bellivier F, Geoffroy PA, Scott J, Schurhoff F, Leboyer M, Etain B Abstract Kraepelin's observations of the differences in the course and outcome of dementia praecox and manic depression fundamentally influenced thinking about bipolar disorder (BP) and schizophrenia (SZ) for over a century. In modern times, there is increasing awareness that a greater understanding of the similarities between these two highly prevalent and disabling conditions can teach us as many lessons about the pathophysiology of severe mental disorders as does the pursuit of differentiating factors. We review publications on developme...
Source: Frontiers in Bioscience - Elite - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement: a quality and meta-analysis.
CONCLUSIONS: The selection of an appropriate surgical modality for BPH should be assessed by fully understanding each patient's clinical conditions. PMID: 23869269 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - November 25, 2014 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Psychosis: a rare but serious psychiatric anomaly in patients with sarcoidosis.
Authors: Kapoor S Abstract I read with great interest the recent article by Hinz et al. 1 Interestingly, sarcoidosis may rarely be associated with manic or psychotic symptoms.   Psychotic disorders are seen in 6.3% of all patients with sarcoidosis, especially in patients with "neurosarcoidosis". 2 Neurosarcoidosis usually occurs in conjunction with systemic sarcoidosis.  Rarely, neurosarcoidosis may be present as an isolated syndrome with no systemic involvement. Overall psychosis is seen in 16.9% of patients with neurosarcoidosis. 3 The cerebrum and the meninges are the sites most commonly involved. However, the...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Optimal transmit phasing for harmonic-background suppression with bipolar square-wave pulser.
In this study, sigma-delta modulation is combined with code tuning to achieve this goal. Measurements of echoes from a wire phantom were performed to investigate the difference in harmonic suppression between the original transmit waveform and its bipolar counterpart. In-vivo cardiac imaging of a rabbit model was also established in the clinical ultrasound system to test the efficacy of a bipolar waveform in optimal transmit phasing. Our results indicate that although the harmonic magnitude becomes abrupt with the transmit phasing when a bipolar waveform is utilized in optimal transmit phasing, effective harmonic suppressi...
Source: Ultrasonic Imaging - November 25, 2014 Category: Radiology Tags: Ultrason Imaging Source Type: research

Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics.
This study used a cross-sectional design, fasting blood draws, and genetic analysis to investigate associations between polymorphisms, haplotypes, and metabolic measures. A total of 320 subjects with schizophrenia (n = 226) or bipolar disorder (n = 94) were included in this study. The mean age of the population was 42.5 years and 45% were male. A significant association between FADS1 and FADS2 haplotypes was found with insulin resistance while controlling for confounders. Further investigation is required to replicate this finding. PMID: 24455201 [PubMed] (Source: Cardiovascular Psychiatry and Neurology)
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Risk of mortality (including sudden cardiac death) and major cardiovascular events in atypical and typical antipsychotic users: a study with the general practice research database.
Conclusions. Antipsychotic users had an increased risk of cardiac mortality, all-cause mortality, and SCD compared to a psychiatric nonuser cohort. PMID: 24455199 [PubMed] (Source: Cardiovascular Psychiatry and Neurology)
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Mood disorders are glial disorders: evidence from in vivo studies.
Authors: Schroeter ML, Abdul-Khaliq H, Sacher J, Steiner J, Blasig IE, Mueller K Abstract It has recently been suggested that mood disorders can be characterized by glial pathology as indicated by histopathological postmortem findings. Here, we review studies investigating the glial marker S100B in serum of patients with mood disorders. This protein might act as a growth and differentiation factor. It is located in, and may actively be released by, astro- and oligodendrocytes. Studies consistently show that S100B is elevated in mood disorders; more strongly in major depressive than bipolar disorder. Successful anti...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Matrix Metalloproteinase-9 (MMP9)-A Mediating Enzyme in Cardiovascular Disease, Cancer, and Neuropsychiatric Disorders.
Authors: Rybakowski JK Abstract Matrix metalloproteinase-9 (MMP9) has been implicated in numerous somatic illnesses, including cardiovascular disorders and cancer. Recently, MMP9 has been shown to be increasingly important in several aspects of central nervous system activity. Furthermore, a pathogenic role for this enzyme has been suggested in such neuropsychiatric disorders as schizophrenia, bipolar illness, and multiple sclerosis. In this paper, the results of biochemical and molecular-genetic studies on MMP9 that have been performed in these pathological conditions will be summarized. Furthermore, I hypothesize...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Saline-coupled bipolar sealing in simultaneous bilateral total knee arthroplasty.
CONCLUSIONS: Bipolar sealing shows promise as a blood loss reduction tool in simultaneous bilateral TKA. The marginal savings attributed to reduced transfusion rates with use of the bipolar sealer did not exceed the additional per-case expense of using the device. The decision to use the device with the goal of less blood loss must come with the additional expense associated with its use. PMID: 25177455 [PubMed - in process] (Source: Clinics in Orthopedic Surgery)
Source: Clinics in Orthopedic Surgery - November 25, 2014 Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

Thank You to Reviewers
(Source: Bipolar Disorders)
Source: Bipolar Disorders - November 25, 2014 Category: Psychiatry Tags: Thank You to Reviewers Source Type: research

Research Roundup
Increased amygdala response to negative stimuli found in adolescents with history of depression Using fMRI to find brain markers for youths with bipolar disorder: A meta‐analysis (Source: The Brown University Child and Adolescent Psychopharmacology Update)
Source: The Brown University Child and Adolescent Psychopharmacology Update - November 25, 2014 Category: Psychiatry Tags: Research Roundup Source Type: research

What's the Manufacturer's Recommended Dosage...
Learn about the available strengths and manufacturer's recommended dosages for Lamictal, a mood stabilizer used in patients with bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 25, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar treatment efficacy
Publication date: November 2014 Source:The Lancet Psychiatry, Volume 1, Issue 6 Author(s): Matthew J Taylor (Source: The Lancet Psychiatry)
Source: The Lancet Psychiatry - November 25, 2014 Category: Psychiatry Source Type: research

Bipolar treatment efficacy – Authors' reply
Publication date: November 2014 Source:The Lancet Psychiatry, Volume 1, Issue 6 Author(s): Tomofumi Miura , Toshi A Furukawa , Andrea Cipriani , Keisuke Motomura , Hiroshi Mitsuyasu , Shiro Tanaka , Stefan Leucht , Satomi Shimano-Katsuki , Georgia Salanti , Hisashi Noma , Sarah Stockton , John R Geddes , Shigenobu Kanba (Source: The Lancet Psychiatry)
Source: The Lancet Psychiatry - November 25, 2014 Category: Psychiatry Source Type: research

A diagnosis of bipolar spectrum disorder predicts diagnostic conversion from unipolar depression to bipolar disorder: A 5-year retrospective study
The major aims of this study were to identify factors that may predict the diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BP) and to evaluate the predictive performance of the bipolar spectrum disorder (BPSD) diagnostic criteria. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - November 25, 2014 Category: Neurology Authors: Young Sup Woo, In Hee Shim, Hee-Ryung Wang, Hoo Rim Song, Tae-Youn Jun, Won-Myong Bahk Tags: Research report Source Type: research

Melancholia and Catatonia: Disorders or Specifiers?
Abstract The fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 defines mental disorders as syndromes and also introduced disorder “specifiers” with the aim of providing increased diagnostic specificity by defining more homogeneous subgroups of those with the disorder and who share certain features. While the majority of specifiers in DSM-5 define a specific aspect of the disorder such as age at onset or severity, some define syndromes that appear to meet the DSM-5 definition of a mental disorder. Specifically, melancholia is positioned in DSM-5 as a major depressive disorder ...
Source: Current Psychiatry Reports - November 24, 2014 Category: Psychiatry Source Type: research

Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?
Authors: Busse M, Busse S, Myint AM, Gos T, Dobrowolny H, Müller UJ, Bogerts B, Bernstein HG, Steiner J Abstract Disturbances of glutamatergic neurotransmission and mononuclear phagocyte system activation have been described uni- and bipolar depression (UD/BD). Linking the glutamate and immune hypotheses of depression, quinolinic acid (QUIN) is synthesized by activated microglia and acts as an endogenous N-methyl-D-aspartate glutamate receptor (NMDA-R) agonist with neurotoxic properties. Recently, we observed an increased microglial QUIN expression in the subgenual and supracallosal, but not in the pregenual part ...
Source: European Archives of Psychiatry and Clinical Neuroscience - November 24, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Retro Report: Debate Persists Over Diagnosing Mental Health Disorders, Long After ‘Sybil’
Bipolar disorder or attention deficit hyperactivity disorder has been diagnosed in millions of Americans, but is that a result of more expert diagnosis, or simply too frequent diagnosis? (Source: NYT Health)
Source: NYT Health - November 24, 2014 Category: Consumer Health News Authors: By CLYDE HABERMAN Tags: Mental Health and Disorders Shirley Ardell Mason Sybil Psychiatry and Psychiatrists Multiple Personalities Dr. Cornelia B. Wilbur Source Type: news

Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion
Cytoplasmic dynein 1 (dynein) is a minus end–directed microtubule motor protein with many cellular functions, including during cell division. The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood. In this paper, we have used small interfering RNAs or morpholino oligonucleotides to deplete the LICs in human cell lines and Xenopus laevis early embryos to dissect the LICs’ role in cell division. We show that although dynein lacking LICs drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. Multipo...
Source: Journal of Cell Biology - November 24, 2014 Category: Cytology Authors: Jones, L. A., Villemant, C., Starborg, T., Salter, A., Goddard, G., Ruane, P., Woodman, P. G., Papalopulu, N., Woolner, S., Allan, V. J. Tags: Articles Source Type: research

Measuring cognitive function in mdd: emerging assessment tools
The objective of this general overview is to briefly review the evidence for cognitive impairment in MDD and to summarize a representative sample of cognitive assessment tools currently available to assess cognitive function in depressed patients. Study results in MDD patients with cognitive dysfunction are somewhat inconsistent, likely due to the heterogeneity of the disorder as well as the use of diverse assessment tools. Measuring cognitive changes in this population is challenging. Cognitive symptoms are typically less severe than in patients with schizophrenia and bipolar disorder, requiring greater sensitivity than a...
Source: Depression and Anxiety - November 24, 2014 Category: Psychiatry Authors: Manuela Russo, Katie Mahon, Katherine E. Burdick Tags: Review Source Type: research

Dopamine receptors – IUPHAR Review 13
The variety of physiological functions controlled by dopamine in the brain and periphery is mediated by the D1, D2, D3, D4 and D5 dopamine GPCRs. Drugs acting on dopamine receptors are significant tools for the management of several neuropsychiatric disorders including schizophrenia, bipolar disorder, depression and Parkinson's disease. Recent investigations of dopamine receptor signalling have shown that dopamine receptors, apart from their canonical action on cAMP‐mediated signalling, can regulate a myriad of cellular responses to fine‐tune the expression of dopamine‐associated behaviours and functions. Such signal...
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Jean‐Martin Beaulieu, Stefano Espinoza, Raul R. Gainetdinov Tags: NC‐IUPHAR REVIEW Source Type: research

Rigour of development of clinical practice guidelines for the pharmacological treatment of bipolar disorder: Systematic review
There is increasing concern about the quality of clinical practice guidelines. Because no information is available on the rigour of development of clinical practice guidelines for bipolar disorder, we carried out a systematic review of those focusing on its pharmacological treatment. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - November 24, 2014 Category: Neurology Authors: Arianna Castellani, Francesca Girlanda, Corrado Barbui Tags: Review Source Type: research

Test-retest reliability of a new questionnaire for the retrospective assessment of long-term lithium use in bipolar disorder
The identification of predictors of treatment response holds tremendous potential for the improvement of clinical outcomes in bipolar disorder (BP). The goal of this project is to evaluate the test-retest reliability of a new clinical tool, the Lithium Questionnaire (LQ), for the retrospective assessment of long-term lithium use in research participants with BP. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - November 24, 2014 Category: Neurology Authors: Sarah K. Tighe, Megan Ritchey, Barbara Schweizer, Fernando S. Goes, Dean MacKinnon, Francis Mondimore, J. Raymond DePaulo, Francis J. McMahon, Thomas G. Schulze, Peter P. Zandi, James B. Potash Tags: Research report Source Type: research

Cariprazine in the treatment of acute mania in bipolar I disorder: A double-blind, placebo-controlled, phase III trial
This phase III, randomized, double-blind, placebo-controlled study investigated the efficacy and tolerability of flexibly-dosed cariprazine in patients with acute manic or mixed episodes associated with bipolar I disorder. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - November 24, 2014 Category: Neurology Authors: Gary S. Sachs, William M. Greenberg, Anju Starace, Kaifeng Lu, Adam Ruth, István Laszlovszky, György Németh, Suresh Durgam Tags: Research report Source Type: research

Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder
The phenomenological overlap between the behavioral changes observed in humans and animals suffering from infection (e.g. anhedonia, fatigue, sleep disturbances, and the desire for social isolation, a.k.a. sickness behavior) and certain symptoms of idiopathic major depression led to the hypothesis that the peripheral immune system communicates with the central nervous system (CNS) to modulate emotions and behavior, and that immunological dysregulation may be an important component of primary mood disorders (Dantzer et al., 2008). (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 24, 2014 Category: Psychiatry Authors: Jonathan Savitz, Robert Dantzer, Brent E. Wurfel, Teresa A. Victor, Bart N. Ford, Jerzy Bodurka, P.S.F. Bellgowan, T. Kent Teague, Wayne C. Drevets Source Type: research

Placebos Can Work - Even When Patients Know...
Astonishing results from a Harvard study showed that placebos worked even when patients knew what they were taking. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Bipolar Teen - Insights on Doctors, Meds and...
Interview with a 14-year-old boy who has bipolar disorder. Zach discussed seeing a psychiatrist, how he feels about taking meds, and what makes him angry. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Delusions of Paranoia and Persecution
Delusions of paranoia and persecution can occur during bipolar mania and depression. Here, four people tell their own experiences with such delusions. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Essential Information About Seroquel (Quetiapine)
Essential information about Seroquel (quetiapine), an antipsychotic medication used to treat psychotic symptoms and bipolar depression. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 23, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Characterization of dsRed2-positive cells in the doublecortin-dsRed2 transgenic adult rat retina
In this study, we characterize dsRed2 reporter protein-expressing cells in the adult retina of the transgenic DCX promoter-dsRed2 rat model, with the aim to identify cells with putative neurogenic activity. Additionally, we confirmed the expression of the dsRed2 protein in DCX-expressing cells in the adult hippocampal dentate gyrus. Adult DCX-dsRed2 rat retinas were analyzed by immunohistochemistry for expression of DCX, NF200, Brn3a, Sox2, NeuN, calbindin, calretinin, PKC-a, Otx2, ChAT, PSA-NCAM and the glial markers GFAP and CRALBP, followed by confocal laser-scanning microscopy. In addition, brain sections of transgenic...
Source: Histochemistry and Cell Biology - November 22, 2014 Category: Biomedical Science Source Type: research

Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses? - Busse M, Busse S, Myint AM, Gos T, Dobrowolny H, Müller UJ, Bogerts B, Bernstein HG, Steiner J.
Disturbances of glutamatergic neurotransmission and mononuclear phagocyte system activation have been described uni- and bipolar depression (UD/BD). Linking the glutamate and immune hypotheses of depression, quinolinic acid (QUIN) is synthesized by activat... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 22, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder - Youssef NA, Bradford DW, Kilts JD, Szabo ST, Naylor JC, Allen TB, Strauss JL, Hamer RM, Brunca M, Shampine LJ, Marx CE.
BACKGROUND: Clozapine and lithium increase neurosteroids in rodents, and both drugs demonstrate antisuicidal actions. We therefore hypothesized that neurosteroid levels may be reduced in patients with schizophrenia or bipolar disorder who completed suicide... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 22, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

The relationship between lifetime suicide attempts, serum lipid levels, and metabolic syndrome in patients with bipolar disorders - Shakeri J, Farnia V, Valinia K, Hashemian AH, Bajoghli H, Holsboer-Trachsler E, Brand S.
OBJECTIVES: To assess the relationship between lifetime suicide attempts (SA), serum lipid values, and metabolic syndrome (MetS) in patients with bipolar disorders (BPD). METHODS: Eighty patients with BPD took part in the study (M=40.60 years). Aft... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 22, 2014 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Recent Progress in Radiofrequency Ablation Therapy for Hepatocellular Carcinoma
In order to attain better ablation and more effective management of hepatocellular carcinoma (HCC), new approaches and devices in radiofrequency ablation (RFA) therapy were presented and discussed in a workshop at the 50th Annual Meeting of the Liver Cancer Study Group of Japan. A novel bipolar RFA apparatus was introduced in Japan in January 2013. Hundreds of subjects with HCC were treated with multipolar RFA with varied devices and plans. Among these, no-touch ablation was one of the most useful procedures in the treatment of HCC with the apparatus. In RFA therapy, a few assisting devices and techniques were applied for ...
Source: Oncology - November 22, 2014 Category: Cancer & Oncology Source Type: research

A short-term evaluation of the safety and the efficacy of bipolar transurethral resection of the prostate in patients with a large prostate (>90g)
Conclusion Bipolar technology makes it possible to use TURP to treat patients with very large prostates and who are at risk when treated by the standard monopolar technology, with a satisfactory safety profile and with favourable efficacy. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - November 22, 2014 Category: Urology & Nephrology Source Type: research

Predominant polarity in bipolar disorder and validation of the polarity index in a German sample
Conclusion: The reason for this negative finding might well be that for several drugs, which were used frequently, no PI value is available. Nevertheless we suggest PP as an important concept in the planning of BD maintenance treatment. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - November 22, 2014 Category: Epidemiology Authors: Julia VolkertKathrin C ZierhutMiriam A SchieleMartina WenzelJuliane KopfSarah Kittel-SchneiderAndreas Reif Source Type: research

Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats
Publication date: Available online 21 November 2014 Source:Journal of Psychiatric Research Author(s): Roger B. Varela , Samira S. Valvassori , Jéssica Lopes-Borges , Edemilson Mariot , Gustavo C. Dal-Pont , Rafaela T. Amboni , Guilherme Bianchini , João Quevedo Bipolar Disorder (BD) is one of the most severe psychiatric disorders. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on manic-like behaviors. Neurotrophins have been considered important mediators in the p...
Source: Journal of Psychiatric Research - November 22, 2014 Category: Psychiatry Source Type: research

Interparental violence and maternal mood disorders as predictors of adolescent physical aggression within the family
This study examined levels of physical IPV perpetration and victimization in mothers with unipolar depression or Bipolar Disorder (BD) and the processes by which maternal physical IPV moderated adolescents' physical aggression in families with maternal mood disorders. Mothers with lifetime mood disorders were predicted to have elevated IPV compared to well mothers, and maternal IPV was expected to moderate the association between lifetime mood disorders and adolescent aggression. Participants included 61 intact families with maternal depression (n = 24), BD (n = 13), or well mothers (n = 24) and two siblings (a...
Source: Aggressive Behavior - November 22, 2014 Category: Psychiatry & Psychology Authors: Angela J. Narayan, Muzi Chen, Pedro P. Martinez, Philip W. Gold, Bonnie Klimes‐Dougan Tags: Research Article Source Type: research

Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans
Publication date: Available online 22 November 2014 Source:International Journal of Psychophysiology Author(s): Aleksandar Kalauzi , Aleksandra Vuckovic , Tijana Bojić Organization of resting state cortical networks is of fundamental importance for the phenomenon of awareness, which is altered in the first part of hypnagogic period (Hori stages 1–4). Our aim was to investigate the change in brain topography pattern of EEG alpha attractor correlation dimension (CD) in the period of transition from Hori stage 1 to 4. EEG of ten healthy adult individuals was recorded in the wake and drowsy states, using a 14 channel aver...
Source: International Journal of Psychophysiology - November 22, 2014 Category: Psychiatry & Psychology Source Type: research

Treatment Moderators of Child- and Family-Focused Cognitive-Behavioral Therapy for Pediatric Bipolar Disorder
Prior work has demonstrated the efficacy of child- and family-focused cognitive-behavioral therapy (CFF-CBT) versus enhanced treatment as usual (TAU; unstructured psychotherapy) for pediatric bipolar disorder (PBD). The current study builds on primary findings by examining baseline child, parent, and family characteristics as moderators of symptom response trajectories. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - November 22, 2014 Category: Psychiatry Authors: Sally M. Weinstein, David Henry, Andrea Katz, Amy T. Peters, Amy E. West Source Type: research

Insight in bipolar disorder: a systematic review
Conclusion Insight is greatly impaired in BD, especially during mania. Several clinical factors seem to influence the level of insight. (Source: Jornal Brasileiro de Psiquiatria)
Source: Jornal Brasileiro de Psiquiatria - November 21, 2014 Category: Psychiatry Source Type: research

Choosing Mania or Depression Without Disorder
Do you have bipolar disorder or know somebody who does? What would change if you could learn how to turn depression and mania on and off whenever you wanted to? The entire way we look at bipolar disorder would change in profound ways. Some are beyond most people’s imagination, but a simple illustration will help you to see why some of us say bipolar is an advantage.read more (Source: Psychology Today Depression Center)
Source: Psychology Today Depression Center - November 21, 2014 Category: Psychiatry & Psychology Authors: Tom Wootton Tags: Depression Evolutionary Psychology Psychiatry Self-Help bipolar disorder Bipolar in order mania mood disorders Tom Wootton Source Type: news

C11: Restoring long term spontaneous voiding in prostate cancer related urinary retention – Bipolar plasma vaporization, a palliative therapeutic approach
Publication date: November 2014 Source:European Urology Supplements, Volume 13, Issue 6 Author(s): B. Geavlete , F. Stanescu , G. Nita , C. Moldoveanu , M. Jecu , C. Ene , C. Bulai , P. Geavlete (Source: European Urology Supplements)
Source: European Urology Supplements - November 21, 2014 Category: Urology & Nephrology Source Type: research

Risperdal (Risperidone) - What You Need to Know
Essential information about Risperdal - generic risperidone - an antipsychotic medication approved to treat several mental disorders, including bipolar. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 21, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Consideration on bipolar manio-depressive disease and the effect of Lithium. A neurophysiological view on mental disorders
Publication date: Available online 20 November 2014 Source:Journal of Psychiatric Research Author(s): Jens Chr. Skou (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 21, 2014 Category: Psychiatry Source Type: research

A genome-wide association study of suicide severity scores in bipolar disorder
Conclusions Our GWAS findings suggest that likely many gene variants of small effects contribute collectively to the risk for suicidal behaviour severity in BD. Larger independent replications are required to strengthen the findings from the GWAS presented here. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - November 21, 2014 Category: Psychiatry Source Type: research

Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine
Publication date: 15 August 2011 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 35, Issue 7 Author(s): Raquel Levin , Mariana Bendlin Calzavara , Camila Maurício Santos , Wladimir Agostini Medrano , Suzy Tamie Niigaki , Vanessa Costhek Abílio Deficits in an operational measure of sensorimotor gating – the prepulse inhibition of startle (PPI) – are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). Some previous studies showed that the spontaneously hypertensive rats (SHR) present PPI deficit. Although SHR is...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 21, 2014 Category: Psychiatry Source Type: research