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Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Recent evidence indicates common genetic, neurobiological, and psychopharmacological aspects of schizophrenia and psychotic affective disorders. Some similarities in neurocognitive deficits associated with these disorders have also been reported. We investigated performance on antisaccade and visually-guided saccade tasks in treatment-naïve first-episode psychosis patients (schizophrenia n=59, major depression n=15, bipolar disorder n=9), matched non-psychotic major depression patients (n=40), and matched healthy individuals (n=106). All psychosis groups displayed elevated antisaccade error rates relative to hea...
Source: Psychiatry Research - November 20, 2009 Category: Psychiatry Authors: Margret S.H. Harris, James L. Reilly, Michael E. Thase, Matcheri S. Keshavan, John A. Sweeney Tags: Articles Source Type: journals

No affective temperament gradient across patient diagnostic groupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is no gradient in affective temperament scores from bipolar I disorder through unipolar depressive patients to healthy individuals, say UK researchers who found high dysthymic scores in both patient groups. (Source: MedWire News - Psychiatry)
Source: MedWire News - Psychiatry - November 20, 2009 Category: Psychiatry Source Type: news

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Risperidone Reduces Acute Manic Symptoms in Bipolar I YouthAripiprazole Study Indicates Promise for Atypicals in Treating Autism SymptomsCommentary by Lead Author Magali Haas, M.D., Ph.D.Weight Gain With Antipsychotics in Treatment-Naïve YouthQuetiapine vs. Risperidone in PsychosisMisuse of ADHD Drugs by College StudentsAdjunctive Lithium for Clozapine-Induced NeutropeniaAntiepileptic Drug Treatment and SchizophreniaTopiramate for Treating Tourette SyndromeLamotrigine-Induced Mania in an Epileptic Child With AutismNew ApprovalUpdated List of Authorized GenericsSafe Drug Disposal (Source: The Brown University Child & Adole...
Source: The Brown University Child & Adolescent Psychopharmacology Update - November 20, 2009 Category: Psychiatry Source Type: journals

Cortical neurochemistry in euthymic patients with bipolar I disorder.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. In contrast to prior findings, we could not observe any metabolic alterations in euthymic patients with bipolar disorder. PMID: 19921970 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 20, 2009 Category: Psychiatry Authors: Scherk H, Backens M, Schneider-Axmann T, Usher J, Kemmer C, Reith W, Falkai P, Gruber O Tags: World J Biol Psychiatry Source Type: journals

Circadian rhythm genes linked to pediatric bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polymorphisms in two genes related to the circadian rhythm may be associated with the development of pediatric bipolar disorder, although not with age at onset, US researchers have discovered. (Source: MedWire News - Pediatrics)
Source: MedWire News - Pediatrics - November 20, 2009 Category: Pediatrics Source Type: news

Videothoracoscopy for isolated atrial fibrillation ablation through bipolar radiofrequencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The video-assisted surgery for the treatment of atrial fibrillation is reproducible and safe. There is a heart failure symptom evolution improvement after the surgery. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Otsuka withdraws application for an extension of indication for aripiprazole (Abilify®) in EUEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: EMEA Area: News Otsuka Pharmaceutical Europe Ltd has informed the European Medicines of its decision to withdraw its application for an extension of indication for aripiprazole (Abilify®) tablets, orodispersible tablets and oral solution. The application had been for use in the treatment of major depressive episodes, as adjunctive therapy, in patients who have had an inadequate response to previous treatment with antidepressants. The drug is currently indicated for the treatment of schizophrenia and for the treatment and prevention of manic episodes in bipolar I disorder. The company stated that the withdrawal wa...
Source: NeLM - Mental Health - November 20, 2009 Category: Psychiatry Source Type: organizations

Lexapro Drug ProfileEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
What is Lexapro? It is an antidepressant in the SSRI class that is approved to treat major depression and generalized anxiety disorder. Here is information about Lexapro including basic information, precautions and warnings, common side effects, and information about Lexapro and pregnancy. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 20, 2009 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: consumer

AnticonvulsantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
s are medications used to treat seizures. Some are also used in bipolar disorder as mood stabilizers. More ... (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - November 20, 2009 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: consumer

Performance analysis and comparison of a minimum interconnections direct storage model with traditional neural bidirectional memoriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study proposes an efficient and improved model of a direct storage bidirectional memory, improved bidirectional associative memory (IBAM), and emphasises the use of nanotechnology for efficient implementation of such large-scale neural network structures at a considerable lower cost reduced complexity, and less area required for implementation. This memory model directly stores the X and Y associated sets of M bipolar binary vectors in the form of (M X Nx) and (M X Ny) memory matrices, requires O(N ) or about 30% of interconnections with weight strength ranging between ±1, and is computationally very efficient...
Source: IET Nanobiotechnology - November 19, 2009 Category: Nanotechnology Source Type: journals

Circadian rhythm genes linked to pediatric bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polymorphisms in two genes related to the circadian rhythm may be associated with the development of pediatric bipolar disorder, although not with age at onset, US researchers have discovered. (Source: MedWire News - Psychiatry)
Source: MedWire News - Psychiatry - November 19, 2009 Category: Psychiatry Source Type: news

A Tissue Framework for Simulating the Effects of Gastric Electrical Stimulation and In Vivo ValidationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastric pacing is used to modulate normal or abnormal gastric slow-wave activity for therapeutic purposes. New protocols are required that are optimized for motility outcomes and energy efficiency. A computational tissue model was developed, incorporating smooth muscle and interstitial cell of Cajal layers, to enable predictive simulations of slow-wave entrainment efficacy under different pacing frequencies. Concurrent experimental validation was performed via high-resolution entrainment mapping in a porcine model (bipolar pacing protocol: 2 mA amplitude; 400 ms pulsewidth; 17-s period; midcorpus). Entrained gastric slow-w...
Source: IEEE Transactions on Biomedical Engineering - November 19, 2009 Category: Biomedical Engineering Source Type: journals

Bipolar resistive switching in individual AuNiOAu segmented nanowiresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Edward D. Herderick, Kongara M. Reddy, Rachel N. Sample, Thomas I. Draskovic, and Nitin P. Padture Evidence for bipolar resistive switching is reported in individual metal-oxide-metal (MOM) nanowires in the system AuNiOAu, and a plausible mechanism for the same is presented. The MOM nanowire architecture may be well suited for much needed fundamental studies of resistive switching because it prov ... [Appl. Phys. Lett. 95, 203505 (2009)] published Tue Nov 17, 2009. (Source: Applied Physics Letters)
Source: Applied Physics Letters - November 19, 2009 Category: Physics Source Type: journals

FDA openly allows criminally-convicted doctors, researchers to keep working on pharmaceuticals and clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The U.S. Government Accountability Office (GAO) recently released a report indicting the U.S. Food and Drug Administration (FDA) for allowing health professionals convicted of crimes to perform research for the agency and to supervise patients' safety during clinical trials.The FDA is required by law to disqualify from positions within its organization doctors that have been convicted of fraud or other crimes. Yet the GAO is publicizing that it takes an average of four years for criminals to be disbarred from their positions.In one case, a doctor who was convicted of 53 counts of criminal offense was allowed ...
Source: NaturalNews.com - November 19, 2009 Category: Consumer Health Advice Source Type: news

Avoiding the effect of item wording by means of bipolar instead of unipolar items: An application to social optimismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scales including positively and negatively worded items usually show an impaired degree of homogeneity. The transformation of unipolar positively and negatively worded items into bipolar items can avoid this disadvantageous effect. The precondition for this transformation is that each pair of items refers to the same topic. It is this topic that serves as the heading of the bipolar item. This scale construction method is demonstrated in the items of the social optimism scale (Schweizer & Schneider, 1997) that comprises unipolar items. The investigation of both the original and the transformed scales in a sample of 808 part...
Source: European Journal of Personality - November 19, 2009 Category: Psychiatry & Psychology Authors: Karl Schweizer, Michael Schreiner Source Type: journals

A systematic association mapping on chromosome 6q in bipolar affective disorder - evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Strong evidence of linkage between chromosomal region 6q16-q22 and bipolar affective disorder (BPAD) has previously been reported. We conducted a systematic association mapping of the 6q-linkage interval using 617 SNP markers in a BPAD case-control sample of German descent (cases = 330, controls = 325). In this screening step, 46 SNPs showed nominally significant BPAD-association (P-values between 0.0007 and 0.0484). Although none of the 46 SNPs survived correction for multiple testing, they were genotyped in a second and ethnically matched BPAD sample (cases = 328, controls = 397). At the melanin-concentrating-hormone-rec...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 19, 2009 Category: Genetics & Stem Cells Authors: Rami Abou Jamra, Thomas G. Schulze, Tim Becker, Felix F. Brockschmidt, Elaine Green, Margrieta A. Alblas, Jens R. Wendland, Mazda Adli, Detelina Grozeva, Jana Strohmeier, Alexander Georgi, Nick Craddock, Peter Propping, Marcella Rietschel, Markus M. Nöth Source Type: journals

Psychiatric syndromes in individuals with chromosome 18 abnormalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study focuses on the presentations of psychiatric syndromes as they relate to specific chromosomal abnormalities of chromosome 18. Twenty-five subjects (13 with an 18q deletion, 9 with 18p tetrasomy, and 3 with an 18p deletion), were interviewed by psychiatrists (blind to specific chromosomal abnormality) using the DIGS (subjects 18 and older) or KSADS-PL (subjects under 18). A consensus best estimation diagnostic process was employed to determine psychiatric syndromes. Oligonucleotide Array Comparative Genomic Hybridization (Agilent Technologies) was utilized to define specific regions of chromosome 18 that were dele...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 19, 2009 Category: Genetics & Stem Cells Authors: Juan Zavala, Mercedes Ramirez, Rolando Medina, Patricia Heard, Erika Carter, AnaLisa Crandall, Daniel Hale, Jannine Cody, Michael Escamilla Source Type: journals

Bipolar Electrode Focusing: The Effect of Current and Electric Field on Concentration EnrichmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analytical Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Analytical Chemistry)
Source: Analytical Chemistry - November 18, 2009 Category: Chemistry Tags: article Source Type: journals

GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The SCZ (schizophrenia)-associated GABA(A) receptor (gamma-aminobutyric acid type A receptor) beta(2) subunit gene GABRB2 was recently associated with BPD (bipolar disorder). Although weaker than its association with SCZ, significant association of GABRB2 with BPD was found in both German and Chinese, especially for the haplotypes rs1816071-rs187269 and rs1816072-rs187269 for which the M-M variants showed higher frequency in disease than the control. Significant genotype-dependent reduction in GABRB2 expression was shown for BPD, but to a lesser extent than that for SCZ. Temporal effects on GABRB2 expression were obser...
Source: Biochemical Society Transactions - November 18, 2009 Category: Biochemistry Authors: Chen J, Tsang SY, Zhao CY, Pun FW, Yu Z, Mei L, Lo WS, Fang S, Liu H, Stöber G, Xue H Tags: Biochem Soc Trans Source Type: journals

Differences between bipolar II and unipolar depression ‘limited’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are limited differences between bipolar II disorder depression and unipolar depression, say Australian scientists who suggest previously suggested differences can be explained by age, gender, and severity. (Source: MedWire News - Psychiatry)
Source: MedWire News - Psychiatry - November 18, 2009 Category: Psychiatry Source Type: news

Mapping and Isolation of the Pulmonary Veins Using the PVAC CatheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:(1) PVAC-guided ablation (i.e., mapping and ablation with a single catheter) results in isolation of all PVs in 73% of the patients. (2) An additional circular mapping catheter is required to increase complete isolation rate to 93% of the patients. (3) Given the esophageal T° rise in almost 50% of patients, safety precautions are needed. (PACE 2009; 1[ndash]11) (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - November 18, 2009 Category: Cardiology Authors: MATTIAS DUYTSCHAEVER, WIM ANNE, GIORGI PAPIASHVILI, YVES VANDEKERCKHOVE, RENE TAVERNIER Source Type: journals

Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small angle x-ray scattering, and molecular theory.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Binary mixtures of C(20)BAS and POPC membranes were studied by solid-state (2)H NMR spectroscopy and small angle x-ray scattering (SAXS) over a wide range of concentrations and at different temperatures. Three specifically deuterated C(20)BAS derivatives--[1',1',20',20'-(2)H(4)]C(20)BAS, [2',2',19',19'-(2)H(4)]C(20)BAS, and [10',11'-(2)H(2)]C(20)BAS--combined with protiated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), as well as membranes containing POPC-d(31) and fully protiated bolalipid, were used in NMR experiments to obtain structural information for the mixtures. The (2)H NMR spectra of [10',11'-(2)H(...
Source: Biophysical Journal - November 18, 2009 Category: Physics Authors: Brownholland DP, Longo GS, Struts AV, Justice MJ, Szleifer I, Petrache HI, Brown MF, Thompson DH Tags: Biophys J Source Type: journals

Are Your Prescription Prices Increasing?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Does it seem like your prescriptions for bipolar disorder are getting more expensive every time you go to the pharmacy? You may be right. There is growing concern that drug manufacturers are raising prices to bolster their return on investment before health care legislation is enacted that might impact what they can charge. Duff Wilson, in an article published Monday by the New York Times, reported that "the industry has raised the wholesale prices of brand-name prescription drugs by about 9 percent, according to industry analysts. That will add more than $10 billion to the nation's drug bill, which is on track to exceed $...
Source: About.com Bipolar Disorder - November 18, 2009 Category: Psychiatry Source Type: consumer

Postoperative analgesia with minidose intrathecal morphine for bipolar hip prosthesis in extremely elderly patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results show that minidose intrathecal morphine provides a good analgesic effect without side effects, and it would be an effective and safe procedure for bipolar hip prosthesis in seniors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-009-0817-5Authors Kazunori Yamashita, Nagasaki Rosai Hospital Department of Anesthesia Sasebo JapanMakoto Fukusaki, Nagasaki Rosai Hospital Department of Anesthesia Sasebo JapanYuko Ando, Nagasaki University School of Medicine Division of Anesthesiology, Department of Translational Medical Science 1-7-1 Sakamoto Nagasaki 852-8501 ...
Source: Journal of Anesthesia - November 17, 2009 Category: Anesthesiology Tags: Journal of Anesthesia Source Type: journals

Comorbid disorders differ among men, women with BDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study findings suggest that illness-related clinical characteristics are similar between men and women with type I and II bipolar disorder, but that comorbid disorder profiles differ significantly between the genders. (Source: MedWire News - Psychiatry)
Source: MedWire News - Psychiatry - November 17, 2009 Category: Psychiatry Source Type: news

The role of dopamine in bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Future research into the pathophysiological mechanisms of bipolar disorder and the development of new treatments for bipolar disorder should focus on the dopaminergic system. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 17, 2009 Category: Psychiatry Authors: David A Cousins, Kelly Butts, Allan H Young Tags: Review Articles Source Type: journals

Star likely to become a Type 1a supernovaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physics Today: A white dwarf star called V445 in the constellation of Puppis, that is digesting its closest neighbor, is a prime candidate to explode as a Type Ia Supernova, ejecting a large quantity of matter into space. V445 Puppis has been under a two-year observation by the European Southern Observatory's Very Large Telescope. The star was discovered by a amateur Japanese astronomer when it became visible as a nova in November 2000. It is the only nova appearing that has no hydrogen and provides the first evidence for an outburst on the surface of a white dwarf dominated by helium. "This is critical, as we know that ...
Source: Physics Today News Picks - November 17, 2009 Category: Physics Authors: Physics Today Source Type: news

Relationships Connections. Seriously?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Relationships are hard. I often think of my marriage like a binary star system with each of us on our own ecliptic but orbiting each other in tandem. However, the reality is that the physics of gravity that keep stars in beautiful synchronicity don't work so well with people. Add a severe mental illness such as bipolar disorder to the equation of relationships and the potential for difficulties is exponential. Lifevirtues, a member of our forums, eloquently shares her fear of relationships, "Damn the social experience. It is a deceitful dynamic; we are perpetually befriending our enemies, and we inevitably hurt the ones w...
Source: About.com Bipolar Disorder - November 17, 2009 Category: Psychiatry Source Type: consumer

Synergetics USA, Inc. Announces Addendum to Marketing Partner Agreement with Codman and Shurtleff, Inc. for Disposable Bipolar ForcepsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OFALLON, Mo.--(HSMN NewsFeed)--Synergetics USA, Inc. (NASDAQ: SURG ), a medical device company that designs, manufactures, and markets innovative microsurgical instruments and other devices, today announced the signing of an addendum to its three year agr... Devices, Neurosurgery, DistributionSynergetics, Codman & Shurtleff, Spetzler-Malis, bipolar forceps (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 16, 2009 Category: Pharmaceuticals Source Type: news

Learn About LexaproEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lexapro is one of the SSRI antidepressants and was created from Celexa (citalopram). The generic name of Lexapro is escitalopram, but Lexapro is not currently available in generic form. There are several warnings about Lexapro, especially about mixing it with other drugs and over-the-counter supplements, and discontinuing Lexapro treatment too quickly can cause a variety of unpleasant side effects. Our Lexapro Drug Profile will give you in-depth information about this antidepressant. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Learn more or join the conversation! NEWSLETTER | FOR...
Source: About.com Bipolar Disorder - November 16, 2009 Category: Psychiatry Source Type: consumer

No medication impact on bipolar neurocognitive performanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The neurocognitive performance of bipolar disorder patients is unaffected by medication use, says a team of researchers in findings that suggest that neurocognitive deficits form a part of the disorder. (Source: MedWire News - Bipolar Disorder)
Source: MedWire News - Bipolar Disorder - November 16, 2009 Category: Psychiatry Source Type: news

Bupropion: Delirium in a patient with bipolar disorder: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Gray matter, white matter, brain, and intracranial volumes in first-episode bipolar disorder: a meta-analysis of magnetic resonance imaging studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The available MRI literature indicates that specific structural brain abnormalities are already present in first-episode bipolar patients. These do not overlap with those emerging from previous meta-analyses performed in patients with chronic BD. These findings support the hypothesis of different patterns of changes in brain morphology over the time course of bipolar disorder. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Antonio Vita, Luca De Peri, Emilio Sacchetti Tags: Review Articles Source Type: journals

A randomized, double-blind, placebo-controlled study of maintenance treatment with adjunctive risperidone long-acting therapy in patients with bipolar I disorder who relapse frequentlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adjunctive RLAT significantly delayed time to relapse in patients with bipolar disorder type I who relapse frequently. Safety and tolerability of RLAT were generally consistent with that previously observed. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Wayne Macfadden, Larry Alphs, J Thomas Haskins, Norris Turner, Ibrahim Turkoz, Cynthia Bossie, Mary Kujawa, Ramy Mahmoud Tags: Original Articles Source Type: journals

Functional imaging of emotional memory in bipolar disorder and schizophreniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results provide evidence that there are distinct patterns of activation in the MTL during an emotional memory task in bipolar disorder and schizophrenia. They also demonstrate that different mood states are associated with different neurobiological responses to emotion across the patient groups. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Heather C Whalley, James McKirdy, Liana Romaniuk, Jessika Sussmann, Eve C Johnstone, Hong I Wan, Andrew M McIntosh, Stephen M Lawrie, Jeremy Hall Tags: Original Articles Source Type: journals

Relationships between auditory event-related potentials and mood state, medication, and comorbid psychiatric illness in patients with bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results suggest that disrupted auditory attention may be observed in BD patients regardless of their mood state at testing, medication status, or history of psychosis. These results extend previous findings, and provide further evidence for aberrations in the P300 ERP as an endophenotype for BD. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Daniel J Fridberg, William P Hetrick, Colleen A Brenner, Anantha Shekhar, Ashley N Steffen, Frederick W Malloy, Brian F O'Donnell Tags: Original Articles Source Type: journals

Stability of symptoms across major depressive episodes in bipolar disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: While the overall dimensional structure of depressive symptoms lacks temporal stability, individual symptoms including suicidality, mood, psychomotor, and neurovegetative symptoms are stable across major depressive episodes in bipolar disorder and should be considered in future investigations of course and pathophysiology in bipolar disorder. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Roy H Perlis, Michael J Ostacher, Rudolf Uher, Andrew A Nierenberg, Francesco Casamassima, Christine Kansky, Joseph R Calabrese, Michael Thase, Gary S Sachs Tags: Original Articles Source Type: journals

Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregiversEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Caregivers, rightly concerned about patients becoming suicidal or depressed, may try to care for the patient at the expense of their own health and well-being. Treatments that focus on the health of caregivers must be developed and tested. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Cheryl A Chessick, Deborah A Perlick, David J Miklowitz, L Miriam Dickinson, Michael H Allen, Chad D Morris, Jodi M Gonzalez, Lauren B Marangell, Victoria Cosgrove, Michael Ostacher Tags: Original Articles Source Type: journals

Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Lithium and carbamazepine preferentially inhibit AC5, albeit via different mechanisms. Lithium competes with Mg2+, which is essential for AC activity; carbamazepine competes for AC's catechol-estrogen site. Antidepressant-like behavior of AC5 knockout mice in the forced-swim test supports the notion that AC5 inhibition is involved in the antidepressant effect of lithium and carbamazepine. The effect of lithium and carbamazepine to lower cAMP formation in AC5-rich dopaminergic brain regions suggests that D1-dopamine receptors in these regions are involved in the antidepressant effect of mood stabilizers. (Sourc...
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Liad Mann, Eliahu Heldman, Yuly Bersudsky, Stephen F Vatner, Yoshihiro Ishikawa, Orna Almog, Robert H Belmaker, Galila Agam Tags: Original Articles Source Type: journals

Effects of night shifts in bipolar disorders and extreme morningnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case highlights the possibility of a sensitizing role of chronotype in triggering episodes of bipolar disorder after the sleep-wake rhythm has been disrupted by night work or shift work. The evaluation of a person's capability to perform night work or shift work should take into account psychiatric disorders and chronotype as well as physical conditions. (Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Robert Meyrer, Joachim Demling, Johannes Kornhuber, Magdalena Nowak Tags: Case Report Source Type: journals

Problems with single-factor solutions in factor analyses of low-end scoresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Pedro Vieira da Silva Magalhães, Patrícia Manzolli, Flávio Kapczinski Tags: Letters to the Editor Source Type: journals

Letter to the Editor: reply to Magalhães et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Philip D. Harvey Tags: Letters to the Editor Source Type: journals

Thank You to ReviewersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Tags: Thank You to Reviewers Source Type: journals

CorrigendumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Bipolar Disorders)
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Tags: Corrigendum Source Type: journals

Smoking Adds Suicide Risk to BPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ABC News and other organizations are reporting on a study that found people with bipolar who smoke appear to have a higher risk of suicidal behavior than those who don't. Prior studies have had similar results, but this time researchers think they have come up with one possible reason. The study by Dr. Michael Ostacher and others at Massachusetts General Hospital looked at 31 smokers and 85 non-smokers. The researchers a standard questionnaire that measured suicidal thoughts and behaviors along with one that measures impulsiveness, as well as noting actual suicide attempts. They found that smokers had a higher rate of im...
Source: About.com Bipolar Disorder - November 16, 2009 Category: Psychiatry Source Type: consumer

Amygdala Activation During Emotion Processing of Neutral Faces in Children With Severe Mood Dysregulation Versus ADHD or Bipolar Disorder.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings support the role of unique neural correlates in face-emotion processing among youths with bipolar disorder, ADHD, and severe mood dysregulation. PMID: 19917597 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 16, 2009 Category: Psychiatry Authors: Brotman MA, Rich BA, Guyer AE, Lunsford JR, Horsey SE, Reising MM, Thomas LA, Fromm SJ, Towbin K, Pine DS, Leibenluft E Tags: Am J Psychiatry Source Type: journals

Decision Resources predicts that the bipolar disorder drug market will decline by more than $US1 billion over the next decade.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - November 15, 2009 Category: Health Management Tags: Short communication Source Type: journals

Treating Bipolar DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study in a recent Journal of the American Medical Association warned psychiatrists that children and teens who take medications for conditions such as bipolar disorder and autism tend to put on a substantial, and worrisome, amount of weight. That weight gain can put young people at risk for chronic health problems as adults, including diabetes and metabolic syndrome. That study will no dou.... (Source: Sound Medicine)
Source: Sound Medicine - November 15, 2009 Category: Global & Universal Authors: Sound Medicine Source Type: info

Ca(V)1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations of human Ca(V)1.2 channel gene were identified only recently. The gain-of-function mutations were found at two mutually exclusive exons in patients with Timothy syndrome (TS). These patients exhibit prolonged QT interval and lethal cardiac arrhythmias. In contrast, the loss-of-function mutations of Ca(V)1.2 channel in patients with Brugada syndrome produce short QT interval that could result in sudden cardiac death. TS patients also suffer from multi-organ dysfunction that includes neurological disorder such as autism and mental retardation reflecting the wide tissue distribution of Ca(V)1.2 channel. Mutation...
Source: Pflugers Archiv : European Journal of Physiology - November 15, 2009 Category: Physiology Authors: Liao P, Soong TW Tags: Pflugers Arch Source Type: journals

Bipolar transurethral resection of the prostate causes less bleeding than the monopolar technique: a single-centre randomized trial of 202 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To compare bipolar with the conventional monopolar transurethral resection of the prostate (TURP) for blood loss and speed of resection. In all, 202 consecutive patients from the hospital waiting list were randomized to undergo TURP using either a bipolar system (Surgmaster TURis, Olympus, Tokyo, Japan) or a monopolar system (24 F, Storz, Tübingen, Germany). The blood loss during and after surgery was measured using a photometer. Other variables compared included indices of resection speed and transfusion rate. There were no statistically significant differences in operative duration, resection weight, resection speed or ...
Source: BJU International - November 14, 2009 Category: Urology & Nephrology Authors: Tim Fagerström, Claes R. Nyman, Robert G. Hahn Source Type: journals