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Aspirin and clopidogrel use in the early postoperative period following on-pump and off-pump coronary artery bypass graftingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Early postoperative clopidogrel combined with aspirin may be safe and beneficial compared with perioperative aspirin treatment alone, in both on-pump and off-pump coronary artery bypass grafting. However, a possibility of selection bias calls for randomized controlled trials to confirm our findings. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Dae Hyun Kim, Constantine Daskalakis, Scott C. Silvestry, Mital P. Sheth, Andrew N. Lee, Suzanne Adams, Sam Hohmann, Sofia Medvedev, David J. Whellan Tags: Perioperative Management Source Type: journals

Mounier–Kuhn syndrome: A rare cause of bronchial dilatation: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of TBM with refractory lower respiratory infection and haemoptysis.The patient was a 53-year-old man with recurrent haemoptysis and without fever, wheezes, chest pain, weight loss or any respiratory disease. Chest helical computed tomography (CT) scan showed tracheomegaly with transversal diameters of the trachea of 50mm. A bronchoscopy was performed and revealed markedly enlarged airways and traces of bleeding arising from the right airways. The haemoptysis was stopped only after bronchial artery embolization. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 20, 2009 Category: Respiratory Medicine Authors: A. Abdelghani, H. Bouazra, A. Hayouni, S. Slama, A. Garrouche, S. Mezghani, N. Klabi, M. Benzarti Source Type: journals

Microdebrider resection of acquired subglottic cysts: Case series and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The laryngeal microdebrider offers a safe and effective way to remove SGC with a low recurrence rate. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Evan R. Ransom, Marcelo B. Antunes, Lee P. Smith, Ian N. Jacobs Tags: Case reports Source Type: journals

Antiplaque and antigingivitis effect of Lippia Sidoides: A double-blind clinical study in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OBJECTIVES: The antiplaque and antigingivitis effect of Lippia Sidoides (LS) was evaluated in this in vivo investigation. MATERIAL AND METHODS: Twenty-three subjects participated in a cross-over, double-blind clinical study, using 21-day partial-mouth experimental model of gingivitis. A toothshield was constructed for each volunteer, avoiding the brushing of the 4 experimental posterior teeth in the lower left quadrant. The subjects were randomly assigned initially to use either the placebo gel (control group) or the test gel, containing 10% LS (test group). RESULTS: The clinical results showed statistically significant di...
Source: Journal of Applied Oral Science - November 20, 2009 Category: Dentistry Source Type: journals

Oral Anticoagulants Redeemed? Daily Dabigatran "Safe" With Dual Antiplatelets After MIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A dose-finding study saw what were characterized as low bleeding rates associated with triple-drug antithrombotic therapy that included the oral anticoagulant dabigatran in patients with a recent ACS event and other cardiovascular risk factors. Heartwire (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

Study Investigates New Pulmonary Embolism ThrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers at Stanford have shown catheter-directed thrombolysis to be an effective procedure in first-line treatment for pulmonary embolism (PE). A meta-analysis published in the Journal of Vascular and Interventional Radiology found that, between 1990 and 2008, the procedure was successful in 86.5% of 594 patients who were at risk of dying of PE. Catheter-directed thrombolysis appeared effective and safer than injecting the high-dose thrombolytic drug into the bloodstream, which can cause bleeding in up to 20% of patients. By targeting blood clots directly, the catheter-based procedure was associated with only a 2.4% ch...
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Recent CDC report shows Chlamydia on the riseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Lowdown on STD’s: Chlamydia Chlamydia is the third most common sexually transmitted infection (STI) in the United States. It is the most common bacteria causing an STI. According to a 2007 Center for Disease Control report, South Carolina ranks 3rd out of the 50 states in chlamydial infections. Those at most risk of infection are single, minority women between ages 15-21 with new or multiple sexual partners. However, Chlamydia affects women and men of all backgrounds. Like all sexually transmitted infections, Chlamydia enters a woman’s body during intercourse. Chl...
Source: Women Speak - November 19, 2009 Category: OBGYN Authors: My name Tags: Infectious Disease Gynecological Health Sex & Relationships Source Type: consumer

Oral anticoagulants REDEEMed? Daily dabigatran "safe" with dual antiplatelets after MIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A dose-finding study saw what were characterized as low bleeding rates associated with triple-drug antithrombotic therapy that included the oral anticoagulant dabigatran in patients with a recent ACS event and other cardiovascular risk factors. (Source: theHeart.org)
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

RE-DEEM: Dabigatran causes no safety concerns in phase II ACS trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When added to dual anti-platelet therapy, the orally administered direct thrombin inhibitor, dabigatran etexilate, results in a “low and acceptable bleeding rate” compared with placebo in patients who have suffered an acute myocardial infarction, according to data presentedat the American Heart Association 2009 Scientific Sessions in, Orlando, Florida, USA. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - November 19, 2009 Category: Internal Medicine Source Type: news

Epidemiology and outcome of snake bite cases evaluated at a Tertiary Care Hospital in OmanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with envenoming following snakebite should receive antivenom as soon as possible: delayed presentation or administration may be very dangerous. The decision to give antivenom should be initiated as soon as possible after patients’ arrival at the Emergency Department and the use of the whole blood clotting test (WBCT) may facilitate the early administration of antivenom. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - November 19, 2009 Category: Global & Universal Authors: Adil Al-Lawati, Seif S. Al-Abri, David G. Lalloo Tags: Original Articles Source Type: journals

Handling Post–Dental Extraction Patients: How to Avoid Trans-Infection of Blood-Borne DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The danger of trans-infection of blood-borne diseases is evident, and a series of measures is proposed to control it. Proper patient education, use of alternative methods of stopping postoperative bleeding other than a gauze pad, appropriate scheduling of appointments of already infected patients, and widespread vaccinations are some such measures. Attention and critical evaluation of the case are necessary because the already existing policies and guidelines are always open to improvements. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - November 19, 2009 Category: ENT & OMF Authors: María Chatzoudi Tags: Basic and Patient-Oriented Research Source Type: journals

Can EP4 Agonist Alleviate Gastric Lesions?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding. To mitigate NSAIDs' adverse effects on the stomach, misoprostol, a non-selective prostaglandin E1 (PGE1) analogue, has been prescribed as the first choice for prevention of NSAID-induced injuries, but often induces severe adverse effects. (Source: Pain / Anesthetics News From Medical News Today)
Source: Pain / Anesthetics News From Medical News Today - November 19, 2009 Category: Anesthesiology Tags: GastroIntestinal / Gastroenterology Source Type: news

AHA: Low Bleeding Rates Observed in Dabigatran Dose-Ranging Trial (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ORLANDO (MedPage Today) -- The oral anticoagulant dabigatran did not appear to markedly increase major bleeding rates among post-MI patients who were already being treated with aspirin and clopidogrel (Plavix), researchers said here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

Swine Flu Deception and Disinformation ExposedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion - a recombinant strain produced from Bird Flu live viruses and a seasonal or Swine Flu strain can create a virus with morbidity (high widespread death rate).Last August, an international microbiologist in California, Joseph Moshe, called anti-vaccination activist Dr. A. True Ott, warning him of a bioweapon at Baxter's facilities in Ukraine that could be used to create a pandemic. Dr. Ott divulged this on Deagle's radio show after Moshe was forcefully apprehended.The Ukrainian IncidentUp until the 29th of October, there were only two non-lethal swine flu cases reported within Ukraine's 46 million population. Very...
Source: NaturalNews.com - November 19, 2009 Category: Consumer Health Advice Source Type: news

Effect of Recombinant Activated Factor VII in Critical Bleeding: Clinical Experience of a Single CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recombinant activated factor VII (rFVIIa) has been successfully used ‘‘off-label’’ in patients with refractory life-threatening hemorrhage. Intravenous rFVIIa was given to 31 patients unresponsive to standard therapy with blood products and surgical reexploration, who were bleeding due to trauma, surgery, organ transplantation, liver cirrhosis, ruptured uterus. We recorded their coagulation and hematologic profiles, acid-base balance, blood loss, number of red blood cells (RBC), plasma and platelet transfusions, complications, and survival. rFVIIa (mean dose 132.2 ± 56.3 µg/kg) effectiv...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Sartori, M. T., Imbergamo, S., Zanon, E., Bonaccorso, G., Pittoni, G., Feltracco, P., Ori, C., Pagnan, A., Cella, G. Tags: Articles Source Type: journals

A Platelet Defect Modulates Bleeding in Mild Hemophilia: The Tale of 2 BrothersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Lapecorella, M., Santacroce, R., Napolitano, M., Bafunno, V., Favuzzi, G., Longo, V., Grandone, E., Mariani, G., Margaglione, M. Tags: Articles Source Type: journals

Peutz-Jeghers syndrome: diagnostic and therapeutic approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280,000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgen...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Kopacova M, Tacheci I, Rejchrt S, Bures J Tags: World J Gastroenterol Source Type: journals

Spontaneous liver rupture in a patient with peliosis hepatis: a case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver failure. Here, we present a young male patient with aplastic anemia, who had received long-term treatment with oxymetholone. The patient suffered from sudden onset of intra-abdominal hemorrhage with profuse hemoperitoneum. The patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative months. We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility ...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Choi SK, Jin JS, Cho SG, Choi SJ, Kim CS, Choe YM, Lee KY Tags: World J Gastroenterol Source Type: journals

RE-DEEM: Dabigatran causes no safety concerns in phase II ACS trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When added to dual anti-platelet therapy, the orally administered direct thrombin inhibitor, dabigatran etexilate, results in a “low and acceptable bleeding rate” compared with placebo in patients who have suffered an acute myocardial infarction, according to data presentedat the American Heart Association 2009 Scientific Sessions in, Orlando, Florida, USA. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - November 19, 2009 Category: Cardiology Source Type: news

Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hepatocellular carcinoma patients with cardiac metastases were in the advanced stages. These patients had limited survival from the diagnosis of cardiac metastases. The most common cause of death was related to HCC per se or the underlying liver disease. Only a few patients expired because of cardiac metastases. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Yu-Chun Liu, Yi-Lwun Ho, Guan-Tarn Huang, Ding-Shinn Chen, Jin-Chuan Sheu, Chien-Hung Chen Source Type: journals

Cervical cytology in patients with postmenopausal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the role of cervical cytology in the diagnosis of post or perimenopausal (PM) bleeding was explored. A total of 135 patients with PM bleeding were selected. In all these cases both conventional cervical cytology and histopathology follow up were available. The commonest causes of postmenopausal (PM) bleeding with abnormal histopathology were squamous cell carcinoma of cervix (14), endocervical polyp (13), endometrial adenocarcinomas (13) and simple hyperplasia without atypia (13). There were a total 13 cases of endometrial adenocarcinoma and cervical smears of these cases were reported as high grade squamous...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Jasleen Kaur, Pranab Dey, Subhash Chandra Saha, Arvind Rajwanshi, Raje Nijhawan, Srinivasan Radhika, Nalini Gupta Source Type: journals

Topical recombinant thrombin at a concentration of 1000 IU/mL reliably shortens in vivo TTH and delivers durable hemostasis in the presence of heparin anticoagulation and clopidogrel platelet inhibition in a rabbit model of vascular bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to evaluate the effect of recombinant human thrombin (rThrombin) concentration on time to hemostasis (TTH), clot durability, and clot strength in settings that replicate the heparinization and platelet inhibition often found in surgical populations. Methods: A modified, anticoagulated rabbit arteriovenous shunt preparation was selected to model vascular anastomotic bleeding. Rabbits were treated with heparin or heparin + clopidogrel and TTH was measured after applying a range of topical rThrombin concentrations or placebo, in combination with absorbable gelatin sponge, USP. Treatments (placebo, rThr...
Source: Annals of Surgical Innovation and Research - November 19, 2009 Category: Surgery Authors: Steven HughesPaul BishopRichard GarciaTracy ZhangW. Allan Alexander Source Type: journals

An unusual cause of obscure gastrointestinal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Tai, C-M, Wang, H-P, Hwang, J-C, Lee, T-C, Lee, C-T, Lin, J-T Tags: GUT Snapshot Editor's quiz Source Type: journals

Apixaban: an emerging oral factor Xa inhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Apixaban, an oral direct factor Xa inhibitor, is currently in late stage clinical development for the prevention and treatment of thromboembolic diseases. In comparison with current treatment standards for venous thromboembolism (VTE) prophylaxis, apixaban has shown decreased rates of clinically significant bleeding with mixed results in terms of non-inferiority for VTE events. Secondary treatment of VTE with apixaban is currently in phase III clinical study after earlier trials showed comparable safety and efficacy outcomes. The APPRAISE-1 trial, a phase II investigation of apixaban versus placebo ...
Source: Journal of Thrombosis and Thrombolysis - November 18, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Evaluation of endometrial thickness with transvaginal ultrasonography and histopathology in premenopausal women with abnormal vaginal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion An endometrial thickness >8 mm is more likely than that of 8 mm or less to be indicated with endometrial biopsy in premenopausal uterine bleeding. Pipelle endometrial biopsy is an accurate diagnostic procedure for the detection of high-grade endometrial lesions in premenopausal women. Content Type Journal ArticleCategory General GynecologyDOI 10.1007/s00404-009-1290-yAuthors Suna Özdemir, Selçuk University Department of Gynecology and Obstetric, Meram Medical Faculty Konya TurkeyÇetin Çelik, Selçuk University Department of Gynecology and Obstetric, Meram Medical Faculty Ko...
Source: Archives of Gynecology and Obstetrics - November 18, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Anorectal symptoms during pregnancy: how important is trimester?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The frequency of anorectal symptom reporting appears to increase as pregnancy progresses. Further investigation and research is warranted to determine the configuration of services that may be required to treat those affected. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0845-5Authors Samit N. Unadkat, Imperial College Department of Biosurgery and Surgical Technology, Faculty of Medicine London UKDaniel R. Leff, Imperial College Department of Biosurgery and Surgical Technology, Faculty of Medicine London UKTiong-Ghee Teoh, Department of Obstetrics and Gynaecolo...
Source: International Journal of Colorectal Disease - November 18, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Laparoscopic correction of enterocele associated to stapled transanal rectal resection for obstructed defecation syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The combination of STARR and laparoscopy provides a safe and effective method to treat ODS caused by rectal internal prolapse and/or rectocele combined with enterocele. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0840-xAuthors Alfonso Carriero, Pelvic Floor Center Montecchio Emilia ItalyMarcello Picchio, Civil Hospital “A. Fiorini” Department of Surgery Via Firenze s.n.c 04019 Terracina ItalyJacopo Martellucci, Pelvic Floor Center Montecchio Emilia ItalyPasquale Talento, Pelvic Floor Center Montecchio Emilia ItalyDomenico Palimento, Civil Hospital “S. Pa...
Source: International Journal of Colorectal Disease - November 18, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Endovascular treatment of largely thrombosed saccular aneurysms: follow-up results in ten patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In a series of ten patients with largely thrombosed aneurysms, this study showed that endovascular treatment of the aneurysms was a safe procedure with a 30% rate of midterm recanalization. These results will provide preliminary information and a meaningful basis for further study on treatment outcomes of this specific subgroup of patients. Content Type Journal ArticleCategory Interventional NeuroradiologyDOI 10.1007/s00234-009-0622-8Authors Young Dae Cho, Seoul National University College of Medicine Department of Radiology 28 Yongon-dong, Jongno-gu Seoul South Korea 110-744Jung Cheol Par...
Source: Neuroradiology - November 18, 2009 Category: Radiology Tags: Neuroradiology Source Type: journals

Major orthopaedic surgeries for haemophilia with inhibitors using rFVIIaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report is the largest clinical report on major orthopaedic surgeries at a single institute. We have concluded that the combination of bolus and continuous infusion of rFVIIa is safe and effective, and more convenient to administer than simple bolus infusion therapy to achieve haemostasis at peri-operative periods. In addition, our data also concurs with the data of several previous reports which showed that orthopaedic surgery for haemophilia patients with inhibitors by means of rFVIIa is safe and effective. (Source: Haemophilia)
Source: Haemophilia - November 18, 2009 Category: Hematology Authors: H. TAKEDANI, H. KAWAHARA, M. KAJIWARA Source Type: journals

The optimal mode of delivery for the haemophilia carrier expecting an affected infant is vaginal deliveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary. The optimal mode of delivery of a haemophilia carrier expecting a child is still a matter of uncertainty and debate. The aim of this commentary/review is to suggest that normal vaginal delivery should be the recommended mode of delivery for the majority of carriers, based on review of studies on obstetric aspects of haemophilia. About 2.0[ndash]4.0% of all haemophilia boys born in countries with a good standard of health care will suffer from ICH during the neonatal period. This is an average figure including all modes of delivery and regardless of whether the carrier status of the mother or the haemophilia status...
Source: Haemophilia - November 18, 2009 Category: Hematology Authors: R. LJUNG Source Type: journals

Hemostasis and inflammation: two of a kind?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the coagulation cascade, tightly controlled by natural anticoagulants and the fibrinolytic system. Inflammation aims at restoring the integrity of damaged or threatened tissues, most frequently because of injury or infectious pathogens. Both are intimately coupled. (Source: Thrombosis Journal)
Source: Thrombosis Journal - November 18, 2009 Category: Hematology Authors: Peter VerhammeMarc Hoylaerts Source Type: journals

Preparing For Tubal Ligation ReversalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Chapel Hill Tubal Reversal Center message board member writes in to ask how best to determine when cycle day 1 starts. This future tubal reversal patient is planning to have a cycle day 3 FSH (Follicle Stimulating Hormone) level drawn prior to her reverse tubal surgery. The first day of menstrual bleeding - spotting does not count- is considered Cycle Day 1. Therefore Cycle Day 3 is the third day of a woman's period. Fertility testing is optional prior to scheduling ligation reversal at Chapel Hill Tubal Reversal Center. Patients or potential patients are welcome to join the Tubal Reversal Message board to have questions...
Source: Tubal Ligation Reversal News - November 18, 2009 Category: Reproduction Medicine Source Type: organizations

Evidence of recombination in Hepatitis C Virus populations infecting a hemophiliac patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although recombination may not appear to be common among natural populations of HCV it should be considered as a possible mechanism for generating genetic diversity in hemophiliacs patients. (Source: Virology Journal)
Source: Virology Journal - November 18, 2009 Category: Virology Authors: Pilar MorenoMacarena AlvarezLilia LopezGonzalo MoratorioDidier CasaneMatias CastellsSilvia CastroJuan CristinaRodney Colina Source Type: journals

Reirradiation to the abdomen for gastrointestinal malignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hyperfractionated accelerated reirradiation to the abdomen was well-tolerated with low rates of acute and late toxicity. Reirradiation could play a role in providing a limited duration of local control in gastrointestinal cancer patients with a history of prior abdominal radiotherapy. (Source: Radiation Oncology)
Source: Radiation Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Waqar HaqueChristopher CraneSunil KrishnanMarc DelclosMilind JavleChristopher GarrettRobert WolffPrajnan Das Source Type: journals

Non-saccular aneurysms of the supraclinoid internal carotid artery trunk causing subarachnoid hemorrhage: acute surgical treatments and review of literaturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to clarify the clinical features of NSAs and the results of early bypass and trapping. Nineteen ruptured NSAs were identified in 937 patients with subarachnoid hemorrhage (SAH). The principal treatment was to trap the aneurysm following bypass surgery as soon as possible after SAH onset. Angiography revealed nine BBAs and ten DAs. Eight patients (four BBA and four DA) were treated in the chronic stage because of delayed arrival (n = 3) or lack of aneurysm on initial angiography (n = 3), or other reasons (n = 2). The remaining 11 patients underwent early surgery using trapping after ...
Source: Urosurgical Review - November 17, 2009 Category: Urology & Nephrology Tags: Neurosurgical Review Source Type: journals

Generalized convulsion resulted in hyperammonemia during treatment with tranexamic acid for hemoptysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This case highlights that generalized convulsion is a very rare, but serious adverse effect of tranexamic acid. Generalized convulsion should be considered as a potential cause of transient hyperammonemia. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11845-009-0453-yAuthors C.-S. Wang, Kaohsiung Municipal Hsiao-Kang Hospital Department of Internal Medicine Kaohsiung Taiwan, ROCC.-J. Yang, Kaohsiung Medical University Hospital, Kaohsiung Medical University Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine No.100, Tzyou 1st Road Kaohsiung 807 Ta...
Source: Irish Journal of Medical Science - November 17, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Musculoskeletal Complications of HemophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The most important clinical strategy for management of patients with hemophilia is the avoidance of recurrent hemarthroses by means of continuous, intravenous hematological prophylaxis. When only intravenous on-demand hematological treatment is available, frequent evaluations are necessary for the early diagnosis and treatment of episodes of intra-articular bleeding. The natural history of the disease in patients with poorly controlled intra-articular bleeding is the development of chronic synovitis and, later, multi-articular hemophilic arthropathy. Once arthropathy develops, the functional prognos...
Source: HSS Journal - November 17, 2009 Category: Orthopaedics Tags: HSS Journal Source Type: journals

Splenic injury following diaphragmatic plication: an avoidable life-threatening complication [Case report - Thoracic non-oncologic]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual complication of left-sided diaphragmatic plication, namely bleeding from the spleen due to tearing of adhesions between the spleen and the abdominal aspect of the diaphragm. We believe that making a small incision in the diaphragm prior to the plication to identify and divide the adhesions could have prevented the complication, and that this manoeuvre should be a standard part of the operation. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - November 17, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Pathak, S., Page, R. D. Tags: Case report - Thoracic non-oncologic Source Type: journals

Splenic tear causing a hemoperitoneum after cardiac surgery [Case report - Cardiac general]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the first case of hemoperitoneum caused by a spontaneous rupture of the spleen. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - November 17, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Ceresa, F., Francio, G., Aldo Intili, P., Patane, F. Tags: Case report - Cardiac general Source Type: journals

Diagnosing cancer in the symptomatic patient.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article addresses several symptoms commonly reported in the primary care setting, including rectal bleeding, a breast lump, cough, lymphadenopathy, and weight loss, and offers an evidence-based approach to the consideration and possibly the diagnosis of cancer. PMID: 19913180 [PubMed - in process] (Source: Primary Care)
Source: Primary Care - November 17, 2009 Category: Primary Care Authors: Salzman BE, Lamb K, Olszewski RF, Tully A, Studdiford J Tags: Prim Care Source Type: journals

FDA Warns of Wound Therapy ComplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (MedPage Today) -- Negative pressure wound therapy (NPWT) may, rarely, cause bleeding, infection, and death, the FDA cautioned. (Source: MedPage Today Product Alert)
Source: MedPage Today Product Alert - November 17, 2009 Category: Drugs & Pharmacology Source Type: news

Ulcer meds may up death risk after heart surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heart patients who take certain stomach-acid-suppressing drugs to prevent gastrointestinal bleeding may be at increased risk of dying after a cardiac procedure, according to a study presented at the annual meeting of the American Heart Association (AHA) in Orlando, Florida. (Source: CNN.com - Health)
Source: CNN.com - Health - November 17, 2009 Category: Consumer Health News Source Type: news

Acute lower gastrointestinal haemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 17, 2009 Category: Journals (General) Authors: Edwards, A. J, Maskell, G. F Tags: Endoscopy, GI bleeding, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Colon cancer, Interventional cardiology, Radiology, Surgical diagnostic tests, Gastrointestinal surgery, General surgery, Radiology (diagnostics), Resuscita Source Type: journals

Xanodyne Announces FDA Approval Of Lysteda(TM) (Tranexamic Acid) For Treatment Of Women With Heavy Menstrual BleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xanodyne Pharmaceuticals, Inc., an integrated specialty pharmaceutical company with both development and commercial capabilities focused on women's healthcare and pain management, announced today that Lysteda(TM) (tranexamic acid) oral tablets has received U.S. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news

Xanodyne Announces FDA Approval Of Lysteda(TM) (Tranexamic Acid) For Treatment Of Women With Heavy Menstrual BleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xanodyne Pharmaceuticals, Inc., an integrated specialty pharmaceutical company with both development and commercial capabilities focused on women's healthcare and pain management, announced today that Lysteda(TM) (tranexamic acid) oral tablets has received U.S. Food and Drug Administration (FDA) approval for treatment of women suffering from cyclic heavy menstrual bleeding (HMB), also known as menorrhagia. (Source: Women's Health / OBGYN News From Medical News Today)
Source: Women's Health / OBGYN News From Medical News Today - November 17, 2009 Category: OBGYN Tags: Women's Health / Gynecology Source Type: news

Ticagrelor shows better efficacy compared to clopidogrel in patients with STEMI and planned PCIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Reuters Health News Area: News According to research presented at the American Heart Association Scientific Session, ticagrelor prevents cardiovascular (CV) events in very high risk patients (those with ST Segment Elevated Myocardial Infarction (STEMI) who require percutaneous coronary intervention (PCI)) with no increased risk of overall major bleeding compared to the current standard of treatment, clopidogrel. Researchers presented the results of the phase III PLATelet inhibition and patient Outcomes (PLATO study) which showed that compared to clopidogrel, treatment with ticagrelor resulted in a reduc...
Source: NeLM - Cardiovascular Medicine - November 17, 2009 Category: Cardiology Source Type: organizations

Addition of cilostazol reduces biological aspirin resistance in aspirin users with ischaemic stroke: a double-blind randomized clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although this was a negative study, our findings disclosed a trend toward enhanced antiplatelet effects when cilostazol was added to aspirin in ischaemic stroke patients. Combination of aspirin and cilostazol might be a treatment option in the ischaemic stroke patients with AR. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: J.-H. Lee, J.-K. Cha, S. J. Lee, S.-W. Ha, S. U. Kwon Source Type: journals

Prognostic Impact of Periprocedural Bleeding and Myocardial Infarction After Percutaneous Coronary Intervention in Unselected Patients: Results From the EVENT (Evaluation of Drug-Eluting Stents and Ischemic Events) RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Among unselected PCI patients, both post-PCI bleeding and pMI are independently associated with increased 1-year mortality. Continued efforts to reduce these complications after PCI are warranted. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - November 16, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Lindsey, J. B., Marso, S. P., Pencina, M., Stolker, J. M., Kennedy, K. F., Rihal, C., Barsness, G., Piana, R. N., Goldberg, S. L., Cutlip, D. E., Kleiman, N. S., Cohen, D. J., on behalf of the EVENT Registry Investigators Tags: Clinical Research Source Type: journals

Enoxaparin Versus Unfractionated Heparin in Elective Percutaneous Coronary Intervention: 1-Year Results From the STEEPLE (SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internationaL randomized Evaluation) TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The 1-year mortality rates were low and comparable between patients receiving enoxaparin and UFH during elective PCI. Periprocedural ischemic or bleeding events were the strongest independent predictors of 1-year mortality. (The STEEPLE Trial; NCT00077844) (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - November 16, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Montalescot, G., Gallo, R., White, H. D., Cohen, M., Steg, Ph. G., Aylward, P. E.G., Bode, C., Chiariello, M., King, S. B., Harrington, R. A., Desmet, W. J., Macaya, C., Steinhubl, S. R., for the STEEPLE Investigators Tags: Clinical Research Source Type: journals