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The Human Bocaviruses: A Review and Discussion of Their Role in InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is a comprehensive review of what is known about HBoV. It includes an evaluation of diagnostic modalities, symptoms occurring in affected patients, and a discussion as to whether HBoV is responsible for identified clinical manifestations. The article reviews the incidence and effect of coinfection and updates on related members (HBoV-2 and HBoV-3) recently reported. Understanding of respiratory viruses such as HBoV remains vitally important to the health of adult and pediatric patients. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - November 4, 2009 Category: Laboratory Medicine Authors: Brian D.W. Chow, Frank P. Esper Source Type: journals

Prevalence of Parvovirus B19 and Human Bocavirus DNA in the Heart of Patients with no Evidence of Dilated Cardiomyopathy or MyocarditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our data suggest that B19V but not HBoV demonstrates a lifelong persistence in the heart. The detection of B19V DNA in heart tissue showed no correlation with clinical symptoms. We strongly recommend that serological testing become a standardized procedure for future studies, to obtain representative data concerning the prevalence of B19V in the heart. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 28, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Detection of Human Bocavirus-2 in children with acute Gastroenteritis in South KoreaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Human bocavirus (HBoV)-2, a new parvovirus, has been identified in stool samples and is suggested to be one of the etiologic agents of acute gastroenteritis (GE). The purpose of this study was to investigate the prevalence of HBoV-2 in children with GE. Stool samples were collected from 358 children hospitalized with GE. HBoV-2 was detected in 3.6% of the patients. HBoV-2 was co-detected with other viral agents in 53.8% of the patients. These findings suggest that HBoV-2 may be an etiologic agent in GE, but further studies are needed due to frequent co-detection with other enteric viruses. Conten...
Source: Archives of Virology - October 28, 2009 Category: Virology Tags: Archives of Virology Source Type: journals

Human bocavirus 2 in children, South Korea.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: In 2009, Kapoor et al. and Arthur et al. published reports on the prevalence of the newly identified parvovirus, human bocavirus 2 (HBoV-2), in fecal samples (1,2). HBoV-1 had been discovered in 2005 (3), and reports indicate its possible role in respiratory diseases such as upper respiratory tract infections, lower respiratory tract infections (LRTIs), and in exacerbation of asthma (4); in these diseases, the virus co-infects with other respiratory viruses (5). Systemic infection with HBoV-1 and possible association of this virus with other diseases such as gastroenteritis, Kawasaki disease, and hepatit...
Source: Emerging Infectious Diseases - October 1, 2009 Category: Infectious Diseases Authors: Han TH, Chung JY, Hwang ES Tags: Emerg Infect Dis Source Type: journals

Sequence analysis of an isolate of minute virus of canines in China reveals the closed association with bocavirus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, we have cloned and sequenced the nearly-full-length genome of minute virus of canines (MVC), SH26, in China. The genome of MVC, 5,132 nucleotides (nts) in length, contains three open reading frames (ORFs), which are 2,325-bp of NS1, 561-bp of NP1 and 2,112-bp of VP1/VP2 encoding three proteins of 774, 186 and 703 residues, respectively. Predicted amino acids sequence of NS1 of MVC has 44% identity with human bocavirus (HBoV) and human boacvirus 2 (HBoV2), NP1 has 48 and 45% identity with HBoV and HBoV2, VP1/VP2 has 45 and 46% identity with HBoV and HBoV2, respectively. Phylogenetic analysis showed...
Source: Molecular Biology Reports - September 16, 2009 Category: Molecular Biology Authors: Shan TL, Cui L, Dai XQ, Guo W, Shang XG, Yu Y, Zhang W, Kang YJ, Shen Q, Yang ZB, Zhu JG, Hua XG Tags: Mol Biol Rep Source Type: journals

Human bocavirus and rhino-enteroviruses in childhood otitis media with effusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that these common respiratory viruses can be associated with OME in children. Whether these viruses are causative etiologic factors of MEE persistence or merely remnants of previous infections is not known. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 6, 2009 Category: Virology Authors: Szilárd Rezes, Maria Söderlund-Venermo, Merja Roivainen, Kaisa Kemppainen, Zsolt Szabó, István Sziklai, Anne Pitkäranta Tags: Full length articles Source Type: journals

Absence of detectable replication of human bocavirus species 2 in respiratory tract.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human bocavirus (HBoV) commonly infects young children and is associated with respiratory disease; disease associations of the divergent HBoV-2 species are unknown. Frequent HBoV-2 detection in fecal samples indicated widespread circulation in the United Kingdom and Thailand, but its lack of detection among 6,524 respiratory samples indicates likely differences from HBoV-1 in tropism/pathogenesis. PMID: 19788826 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - August 31, 2009 Category: Infectious Diseases Authors: Chieochansin T, Kapoor A, Delwart E, Poovorawan Y, Simmonds P Tags: Emerg Infect Dis Source Type: journals

Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children, Finland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus-like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy adults in Finland were examined. Our assays had a sensitivity of 97% and a specificity of 99.5%. Of adults, 96% had immunity; none had an acute infection. Of 48 children with serologically diagnosed acute HBoV infections, 45 were viremic and 35 had virus in nasopharyngeal aspirates (NPAs). Of 39 HBoV NPA P...
Source: Emerging Infectious Diseases - August 31, 2009 Category: Infectious Diseases Authors: Söderlund-Venermo M, Lahtinen A, Jartti T, Hedman L, Kemppainen K, Lehtinen P, Allander T, Ruuskanen O, Hedman K Tags: Emerg Infect Dis Source Type: journals

Simultaneous detection of human bocavirus and adenovirus by multiplex real-time PCR in a Belgian paediatric population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since the discovery of human bocavirus (hBoV), the virus has been detected worldwide in respiratory tract samples from young children by various polymerase chain reaction (PCR) assays and real-time PCRs (Q-PCR). Until now, no data have been reported on the presence of hBoV in Belgium and the detection of hBoV in a multiplex Q-PCR setting has not been described. The aim of this study was to develop a fast and reliable multiplex Q-PCR for the simultaneous detection of hBoV DNA and adenovirus (AdV) DNA. During the winter of 2004-2005, 445 nasopharyngeal aspirates (NPAs) were analysed from 404 Belgian children up to 5 year...
Source: Adv Data - August 24, 2009 Category: Epidemiology Authors: De Vos N, Vankeerberghen A, Vaeyens F, Van Vaerenbergh K, Boel A, De Beenhouwer H Tags: Eur J Clin Microbiol Infect Dis Source Type: journals

Simultaneous detection of human bocavirus and adenovirus by multiplex real-time PCR in a Belgian paediatric populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Since the discovery of human bocavirus (hBoV), the virus has been detected worldwide in respiratory tract samples from young children by various polymerase chain reaction (PCR) assays and real-time PCRs (Q-PCR). Until now, no data have been reported on the presence of hBoV in Belgium and the detection of hBoV in a multiplex Q-PCR setting has not been described. The aim of this study was to develop a fast and reliable multiplex Q-PCR for the simultaneous detection of hBoV DNA and adenovirus (AdV) DNA. During the winter of 2004–2005, 445 nasopharyngeal aspirates (NPAs) were analysed from 404 Belgian...
Source: European Journal of Clinical Microbiology & Infectious Diseases - August 24, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals

The first detection of human bocavirus 2 infections in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human bocavirus (HBoV) was firstly discovered in children with respiratory tract infections (RTIs), but also has been found in children with gastroenteritis. The association between HBoV and respiratory infections and gastroenteritis are determined. Human bocavirus 2 (HBoV2), which is one species of the subfamily Parvovirinae of the family Parvoviridae, was firstly reported in children by Kapoor et al. To extend these initial findings and assess the pathogenicity of HBoV and HBoV2, we investigated their prevalence in children in China. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 11, 2009 Category: Virology Authors: T.L. Shan, W. Zhang, W. Guo, L. Cui, C.L. Yuan, X.Q. Dai, Q. Shen, Z.B. Yang, J.G. Zhu, X.G. Hua Tags: Letter to the Editor Source Type: journals

Prevalence and clinical aspects of human bocavirus infection in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect Human bocavirus (HBoV) was recently described as a new member of the Parvoviridae. In order to investigate the suggested association of HBoV with respiratory and gastric disease in infants and young children, sera of 357 paediatric patients hospitalized with infectious and non-infectious diseases were retrospectively analyzed for the presence of HBoV DNA and virus-specific antibodies using quantitative PCR and ELISA, respectively. HBoV seroprevalence was determined to range from 25% in infants younger than 1 year of age to 93% in children aged more than 3 years. Viral loads between 1 × 102 and 1.2 ×...
Source: Clinical Microbiology and Infection - August 3, 2009 Category: Microbiology Authors: L. Karalar, J. Lindner, S. Schimanski, M. Kertai, H. Segerer, S. Modrow Source Type: journals

Human Bocavirus: A Cause of Severe Asthma Exacerbation in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Real-time polymerase chain reaction for human bocavirus (HBoV) was performed in nasopharyngeal aspirate specimens from 166 children over 2 years of age hospitalized for severe asthma exacerbation. Whereas HBoV was detected in 21 of these children (13%), it was found in only 1 of 50 ambulatory children with stable asthma (2%), suggesting a major role of HBoV in acute exacerbations in asthmatic children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 22, 2009 Category: Pediatrics Authors: Christelle Vallet, Charlotte Pons-Catalano, Alexis Mandelcwajg, Andrew Wang, Josette Raymond, Pierre Lebon, Dominique Gendrel Tags: Clinical and Laboratory Observations Source Type: journals

[Media Watch] Books: The dictionary of virologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently we have witnessed an explosion in virus discovery. The highest profile of these “new” viruses is the severe acute respiratory syndrome coronavirus, which made its debut in 2001 with an alarming pandemic that infected 8000 people around the world and claimed 800 victims before it was brought under control. With new and rapid molecular techniques for virus discovery, and the recent development of mass sequencing, many new human and veterinary viruses have been discovered. These include several new polyomaviruses and picornaviruses, many of which might be pathogenic, and human bocavirus, which is implicated in ch...
Source: The Lancet Infectious Diseases - July 19, 2009 Category: Infectious Diseases Authors: Dorothy H Crawford Tags: Media Watch Source Type: journals

Detection of enteric viruses in rectal swabs from children with acute gastroenteritis attending the pediatric outpatient clinics in Sapporo, JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of each enteric virus in outpatients resembled that previously estimated in hospitalized patients, although the detection rate of rotavirus was slightly low. The contribution of bocavirus appears to be small. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 15, 2009 Category: Virology Authors: Kaori Nakanishi, Takeshi Tsugawa, Shinjiro Honma, Shuji Nakata, Masatoshi Tatsumi, Yuko Yoto, Hiroyuki Tsutsumi Tags: Short communications Source Type: journals

Prevalence of human bocavirus in human tonsils and adenoids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19624951 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - June 30, 2009 Category: Infectious Diseases Authors: Clément N, Battaglioli G, Jensen RL, Schnepp BC, Johnson PR, St George K, Linden RM Tags: Emerg Infect Dis Source Type: journals

Detection of, and frequent co-infection with, human bocavirus in faecal specimens from children in Wuhan, ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect A novel parvovirus, human bocavirus (HBoV), was first discovered in children with respiratory tract infections in Sweden. A retrospective study of HBoV in faecal samples from children suffering from diarrhea, covering a 3-year period (November 2000 to October 2003) in Wuhan, China, was undertaken. PCR assays were used to evaluate 214 faecal samples and to determine the role of HBoV in diarrhoea. Among 196 virus-infected children with diarrhoea, 2.55% were HBoV-positive; however, all HBoV-positive patients were co-infected with common enteric viruses. This result does not support the notion that HBoV i...
Source: Clinical Microbiology and Infection - June 21, 2009 Category: Microbiology Authors: Y. Huang, P. Mao, H. Wang Source Type: journals

No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - May 26, 2009 Category: Virology Authors: Martin Enders, Juha Lindner, Jürgen J. Wenzel, Carola Baisch, Gunnar Schalasta, Gisela Enders, Susanne Modrow Tags: Full length articles Source Type: journals

Detection of Human Bocavirus in bronchoalveolar lavage from Italian adult patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, no specimen resulted positive to HBoV and the authors concluded that this argued against a role for HBoV as a respiratory pathogen or co-pathogen in lung transplantation, as well as against a role as a bystander in the respiratory tract of adults. We have conducted a prospective study on HBoV prevalence in 341 consecutive BAL samples over an 18-month period. Bronchoalveolar lavage was performed for investigating the cause of unexplained fever and/or respiratory symptoms and/or new infiltrates on chest X-ray or as routine follow-up in lung transplant recipients at month 1 post-transplantation and subsequently...
Source: Journal of Clinical Virology - April 29, 2009 Category: Virology Authors: Cristina Costa, Massimiliano Bergallo, Rossana Cavallo Tags: Letters to the Editor Source Type: journals

Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: HRVs were proportionately under-represented among viral co-detections. For some period, HRVs may render the host less likely to be infected by other viruses. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - April 29, 2009 Category: Virology Authors: R.M. Greer, P. McErlean, K.E. Arden, C.E. Faux, A. Nitsche, S.B. Lambert, M.D. Nissen, T.P. Sloots, I.M. Mackay Tags: Full length articles Source Type: journals

[Respiratory infection] Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this cohort of hospitalised adults, respiratory viruses detected in BAL fluid specimens were associated with respiratory symptoms, absence of radiological infiltrates and a poor response to antibiotic therapy. (Source: Thorax)
Source: Thorax - April 28, 2009 Category: Respiratory Medicine Authors: Garbino, J, Soccal, P M, Aubert, J-D, Rochat, T, Meylan, P, Thomas, Y, Tapparel, C, Bridevaux, P-O, Kaiser, L Tags: Respiratory infection Source Type: journals

Detection of Human Bocavirus from Fecal Samples of Hungarian Children with Acute GastroenteritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intervirology 2009;52:17-21 (DOI:10.1159/000210834) (Source: Karger Publishers)
Source: Karger Publishers - April 6, 2009 Category: Cancer & Oncology Source Type: journals

Phylogenetic analysis of human bocavirus (HBoV) detected from children with acute respiratory infection in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, in an attempt to clarify the epidemiology, we performed phylogenetic analysis of HBoV detected from Japanese children with ARI in recent years. (Source: Journal of Infection)
Source: Journal of Infection - April 1, 2009 Category: Infectious Diseases Authors: Ikumi Hishinuma-Igarashi, Katsumi Mizuta, Yoshihiro Saito, Yoshimi Ohuchi, Masahiro Noda, Miho Akiyama, Hiroshi Sato, Hiroyuki Tsukagoshi, Nobuhiko Okabe, Masato Tashiro, Hirokazu Kimura Tags: Letters to the Editor Source Type: journals

Detection of Human Bocavirus in bronchoalveolar lavage from Italian adult patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19324589 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 24, 2009 Category: Virology Authors: Costa C, Bergallo M, Cavallo R Tags: J Clin Virol Source Type: journals

Human bocavirus and KI/WU polyomaviruses in pediatric intensive care patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We evaluated the prevalence of human bocavirus and KI and WU polyomaviruses in pediatric intensive care patients with and without lower respiratory tract infection (LRTI). The prevalence of these viruses was 5.1%, 0%, and 2.6%, respectively, in children with LRTI and 4.8%, 4.8%, and 2.4%, respectively, in those without LRTI. PMID: 19239763 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - February 28, 2009 Category: Infectious Diseases Authors: van de Pol AC, Wolfs TF, Jansen NJ, Kimpen JL, van Loon AM, Rossen JW Tags: Emerg Infect Dis Source Type: journals

[Paediatric lung disease] Induced sputum in the diagnosis of childhood community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sputum induction provides good quality sputum specimens with high microbiological yield in children with community-acquired pneumonia. Induced sputum analysis can be useful in the microbiological diagnosis of childhood community-acquired pneumonia. (Source: Thorax)
Source: Thorax - February 27, 2009 Category: Respiratory Medicine Authors: Lahti, E, Peltola, V, Waris, M, Virkki, R, Rantakokko-Jalava, K, Jalava, J, Eerola, E, Ruuskanen, O Tags: Paediatric lung disease Source Type: journals

Evidence of prior exposure to Human Bocavirus: a retrospective serological study of 404 adult sera in the United States.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently, molecular screening for pathogenic agents has identified a partial genome of a novel parvovirus, called human bocavirus (HBoV). The presence of this newly described parvovirus correlated with upper and lower respiratory tract infections (LRTI) in children. LRTIs are a leading cause of hospital admission in children and the etiological agent has not been identified in up to 39% of these cases. Using baculovirus expression vectors (BEVs) and insect cell system; we produced virus-like-particles (VLP) of HBov. The engineered BEVs express the HBov capsid proteins stoichiometrically from a single open reading frame...
Source: Clinical and Vaccine Immunology - February 25, 2009 Category: Allergy & Immunology Authors: Cecchini S, Negrete A, Virag T, Graham B, Cohen JI, Kotin RM Tags: Clin Vaccine Immunol Source Type: journals

Clinical and microbiological impact of human bocavirus on children with acute otitis mediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, HBoV may worsen the clinical symptoms and prolong the clinical outcome of AOM in pediatric population. Finally, HBoV may prime the secondary bacterial infection in the middle ear in favor of S. pneumoniae. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00431-009-0939-7Authors Levent Bekir Beder, Wakayama Medical University Department of Otolaryngology-Head and Neck Surgery Kimiidera 811-1, Wakayama-shi 641-0012 Wakayama JapanMuneki Hotomi, Wakayama Medical University Department of Otolaryngology-Head and Neck Surgery Kimiidera 811-1, Wakayama-shi 641-0012 Wakayama JapanMasashi Ogami, W...
Source: European Journal of Pediatrics - February 17, 2009 Category: Pediatrics Tags: European Journal of Pediatrics Source Type: journals

Healthcare-Associated Atypical PneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the history, epidemiology, and pathogenesis of infection; control of infection; clinical findings; diagnosis; and, where applicable, treatment of the agents of healthcare-associated atypical pneumonia. Bacterial agents include species, , species, and . Although there are over 100 viruses that can cause respiratory tract infections, only a fraction of those have been defined in the context of healthcare-associated atypical pneumonia: adenovirus and human bocavirus (HBoV); rhinovirus; human coronaviruses (HCoV), including HCoV 229E, HCoV OC43, HCoV NL63, HCoV HKU1; members of the paramyxoviridae (parai...
Source: Seminars in Respiratory and Critical Care Medicine - February 8, 2009 Category: Respiratory Medicine Source Type: journals

Clinical and genetic analysis of Human Bocavirus in children with lower respiratory tract infection in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: HBoV may have circulated in Taiwan for some time and it appears to be one of the etiological agents responsible for lower respiratory tract infection in children. PMID: 19208496 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - February 7, 2009 Category: Virology Authors: Lin JH, Chiu SC, Lin YC, Chen HL, Lin KH, Shan KH, Wu HS, Liu HF Tags: J Clin Virol Source Type: journals

Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To reduce morbidity and mortality through integrated case management, a pilot study to detect respiratory viruses in patients with acute lower respiratory infections (ALRIs) was designed as part of a nationwide surveillance for this disease in Korea. The study population consisted of hospitalized patients under the age of 5 years with bronchiolitis, pneumonia, croup, or acute respiratory distress syndrome. A prospective 6-month study was performed. Two hundred and ninety-seven nasopharyngeal secretions were collected and multiplex reverse transcriptase polymerase chain reactions (RT-PCR)/polyme...
Source: European Journal of Clinical Microbiology & Infectious Diseases - February 4, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals

Human Bocavirus and KI/WU Polyomaviruses in Pediatric Intensive Care Patients, A.C. van de Pol et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - February 3, 2009 Category: Infectious Diseases Source Type: journals

Detection of human bocavirus in hospitalised childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results contribute to the interest in the HBoV detection in children. HBoV detection in hospitalised children with or without any other respiratory virus detection was essentially associated with lower respiratory tract infection and in a lower score with upper respiratory tract infection and gastroenteritis. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - February 3, 2009 Category: Pediatrics Authors: Julia Dina, Astrid Vabret, Stephanie Gouarin, Joelle Petitjean, Julie Lecoq, Jacques Brouard, Alina Arion, Françoise Lafay-Delaire, François Freymuth Source Type: journals

Human Metapneumovirus and Human Bocavirus in Children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several new viruses have recently been described in children, including human metapneumovirus (hMPV) and human bocavirus (HBoV). hMPV has been established as a common cause of upper and lower respiratory tract infections in children, often second only to respiratory syncytial virus as a cause of bronchiolitis in infants. Diagnostic tools have been developed for the clinician and effective treatment and prevention strategies are being investigated. HBoV was more recently identified. Although it was initially identified in the airway of children, high rates of co-detection of other viral pathogens and detection of the vi...
Source: Pediatric Research - January 28, 2009 Category: Pediatrics Authors: Milder E, Arnold JC Tags: Pediatr Res Source Type: journals

Humoral Immune Response Against Human Bocavirus VP2 Virus-Like ParticlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Viral Immunology Dec 2008, Vol. 21, No. 4: 443-450. Human bocavirus (HBoV) was recently detected in samples from children and infants with infections of the respiratory tract. Here we analyze the prevalence of IgG and IgM antibodies against HBoV virus-like VP2 particles in healthy adult blood donors and ... (Source: Viral Immunology)
Source: Viral Immunology - December 30, 2008 Category: Allergy & Immunology Tags: article Source Type: journals

Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We have developed a real-time reverse transcription-PCR (RT-PCR) method to detect 13 respiratory viruses: influenza virus A and B; respiratory syncytial virus (RSV) subgroup A and B; parainfluenza virus (PIV) 1, 2, and 3; adenovirus; rhinovirus (RV); enterovirus; coronavirus (OC43); human metapneumovirus (hMPV); and human bocavirus (HBoV). The new method for detection of these viruses was applied simultaneously with real-time PCR for the detection of six bacterial pathogens in clinical samples from 1700 pediatric patients with community-acquired pneumonia (CAP). Of all the patients, 32.5% were suspe...
Source: Journal of Infection and Chemotherapy - December 17, 2008 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Absence of human Bocavirus in bronchoalveolar lavage fluid of lung transplant patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19083266 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - December 9, 2008 Category: Virology Authors: Miyakis S, van Hal SJ, Barratt J, Stark D, Marriott D, Harkness J Tags: J Clin Virol Source Type: journals

Comparison of four nasal sampling methods for the detection of viral pathogens by RT-PCR-A GA(2)LEN project.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to compare the efficacy and patient discomfort between four techniques for obtaining nasal secretions. Nasal secretions from 58 patients with symptoms of a common cold, from three clinical centers (Amsterdam, Lodz, Oslo), were obtained by four different methods: swab, aspirate, brush, and wash. In each patient all four sampling procedures were performed and patient discomfort was evaluated by a visual discomfort scale (scale 1-5) after each procedure. Single pathogen RT-PCRs for Rhinovirus (RV), Influenza virus and Adenovirus, and multiplex real-time PCR for RV, Enterovirus, Influenza virus, A...
Source: Journal of Virological Methods - November 25, 2008 Category: Virology Authors: Spyridaki IS, Christodoulou I, de Beer L, Hovland V, Kurowski M, Olszewska-Ziober A, Carlsen KH, Lødrup-Carlsen K, van Drunen CM, Kowalski ML, Molenkamp R, Papadopoulos NG Tags: J Virol Methods Source Type: journals

Human Bocavirus Is a Common, Asymptomatic Infection in InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recently discovered human bocavirus, a parvovirus found in the respiratory tracts of children with acute respiratory tract infections and in the feces of children with gastroenteritis, does not appear to be the cause of illness, Danish researchers report in the October issue of The Pediatric Infectious Disease Journal. Reuters Health Information (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - November 7, 2008 Category: Pediatrics Tags: Pediatrics Source Type: info

Human bocavirus infection in children with acute gastroenteritis and healthy controls.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human bocavirus (HBoV) is a novel virus which can cause respiratory tract disease in infants and children. Recently, the prevalence of this virus was studied worldwide not only in the respiratory tract, but also in the gastrointestinal tract. The results of this study focusing on the HBoV detection in stool samples showed that HBoV could only be found in the stool of children with acute gastroenteritis (0.9%), not in the healthy control samples. Moreover, the complete coding sequences of these HBoV also showed very conserved sequences. PMID: 19050360 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - November 1, 2008 Category: Infectious Diseases Authors: Chieochansin T, Thongmee C, Vimolket L, Theamboonlers A, Poovorawan Y Tags: Jpn J Infect Dis Source Type: journals

Human Bocavirus Infection in Children With Respiratory Tract Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 969DOI: 10.1097/INF.0b013e31817acfaaAuthors: Brieu, Nathalie MSc *; Guyon, Gael MD +; Rodiere, Michel MD +; Segondy, Michel PhD *; Foulongne, Vincent PhD * (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 28, 2008 Category: Infectious Diseases Tags: Abstract HTML PDF (227 K) Source Type: journals

Role of Human Bocavirus infections in outbreaks of gastroenteritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study indicates that HBoV is not a causative agent for gastroenteritis outbreaks. PMID: 18835213 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - October 1, 2008 Category: Virology Authors: Campe H, Hartberger C, Sing A Tags: J Clin Virol Source Type: journals

Bocavirus infections in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pediatric Health , October 2008, Vol. 2, No. 5, Pages 549-551. (Source: Future Medicine: Pediatric Health)
Source: Future Medicine: Pediatric Health - September 29, 2008 Category: Pediatrics Tags: article Source Type: journals

Clinical and Epidemiologic Characteristics of Human Bocavirus in Danish Infants: Results From a Prospective Birth Cohort Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 897DOI: 10.1097/INF.0b013e3181757b16Authors: von Linstow, Marie-Louise MD, PhD *; Hogh, Mette MSc, PhD +; Hogh, Birthe MD, DMSc * (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 27, 2008 Category: Infectious Diseases Tags: Abstract HTML PDF (257 K) Source Type: journals

Clinical and epidemiological aspects of human bocavirus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human bocavirus was recently described as a novel member of the Parvoviridae to infect humans. Based on accumulating clinical and epidemiological data the virus is currently being associated with respiratory infections in young children and infants and is furthermore discussed as causative agent of gastrointestinal illness. PMID: 18823816 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 25, 2008 Category: Virology Authors: Lindner J, Karalar L, Schimanski S, Pfister H, Struff W, Modrow S Tags: J Clin Virol Source Type: journals

Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HBoV circulates in Cleveland, OH, in children and adults with similar frequencies, and can warrant hospitalization and intensive care. Further study would clarify our understanding of this newly recognized human pathogen. PMID: 18805051 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 18, 2008 Category: Virology Authors: Chow BD, Huang YT, Esper FP Tags: J Clin Virol Source Type: journals

The challenge of respiratory virus infections in hematopoietic cell transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the spectrum of pathogens, epidemiology, risk factors and clinical manifestations of infection, as well as recent advances in diagnostic and clinical management. (Source: British Journal of Haematology)
Source: British Journal of Haematology - September 12, 2008 Category: Hematology Authors: Michael Boeckh Source Type: journals

Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: HBoV was detected in about 5% of children with acute lower respiratory infection seen in Beijing Children's Hospital. Further investigations regarding clinical and epidemiologic characteristics of HBoV infection are needed. PMID: 19024084 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - September 5, 2008 Category: Journals (General) Authors: Zhang LL, Tang LY, Xie ZD, Tan XJ, Li CS, Cui AL, Ji YX, Xu ST, Mao NY, Xu WB, Shen KL Tags: Chin Med J (Engl) Source Type: journals

Bocavirus infection in children: what should be the next to do?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19024083 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - September 5, 2008 Category: Journals (General) Authors: Zhaori GT Tags: Chin Med J (Engl) Source Type: journals

No gastroenteric Bocavirus in high risk patients stool samples.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18755626 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 26, 2008 Category: Virology Authors: Ziegler S, Tillmann RL, Müller A, Simon A, Schildgen V, Schildgen O Tags: J Clin Virol Source Type: journals