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Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
rzej Stepulak Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modul...
Source: Cancers - September 23, 2023 Category: Cancer & Oncology Authors: Paulina Miziak Marzena Baran Ewa B łaszczak Alicja Przybyszewska-Podstawka Joanna Ka łafut Jolanta Smok-Kalwat Magdalena Dmoszy ńska-Graniczka Micha ł Kiełbus Andrzej Stepulak Tags: Review Source Type: research

AstraZeneca Surges As It Takes A Shot At Gilead ' s Second-Biggest Cancer Drug
and Daiichi Sankyo said Friday their breast cancer treatment outperformed chemotherapy in a Phase 3 study, and AZN stock jumped to its 50-day line. The companies are in the antibody drug conjugate, or ADC, space with a medicine called datopotamab deruxteca. ADCs are like smart bombs, targeting…#daiichisankyo #azn #astrazeneca #adc #marketsmithcom #trodelvy #gileadsciences #gild #isi #umerraffat
Source: Reuters: Health - September 22, 2023 Category: Consumer Health News Source Type: news

what med schools would you recommend with ucat 2530 B2 and gcses 4 9s,4 8s, a 7
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Source: The Student Room - September 22, 2023 Category: Universities & Medical Training Authors: ceezee Tags: Medicine Source Type: forums

A Multicenter RWS Study Comparing the Benefits of Continued Use of OFS After 5 Years
Condition:   To Observe and Evaluate the Clinical Efficacy and Safety of Continuous Use of OFS for Premenopausal Patients With Early Breast Cancer After 5 Years Interventions:   Drug: OFS continues to use group after 5 years;   Diagnostic Test: Immunohistochemical detection of HR status Sponsor:   Hongmei Zheng Active, not recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

The Effect of Simulation-Based Breast Health Education on Breast Cancer Awareness and Breast Self-Examination Practices
Conditions:   Breast Cancer;   Health Knowledge, Attitudes, Practice Intervention:   Behavioral: simulation-based breast health education Sponsor:   Hacettepe University Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

A Multicenter RWS Study Comparing the Benefits of Continued Use of OFS After 5 Years
Condition:   To Observe and Evaluate the Clinical Efficacy and Safety of Continuous Use of OFS for Premenopausal Patients With Early Breast Cancer After 5 Years Interventions:   Drug: OFS continues to use group after 5 years;   Diagnostic Test: Immunohistochemical detection of HR status Sponsor:   Hongmei Zheng Active, not recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

The Effect of Simulation-Based Breast Health Education on Breast Cancer Awareness and Breast Self-Examination Practices
Conditions:   Breast Cancer;   Health Knowledge, Attitudes, Practice Intervention:   Behavioral: simulation-based breast health education Sponsor:   Hacettepe University Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

AstraZeneca, Daiichi post early win in Phase 3 trial for breast cancer therapy
Source: Reuters: Health - September 22, 2023 Category: Consumer Health News Source Type: news

Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research

Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research

Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research

Characterization of the Tumor Microenvironment of De Novo Oligometastatic Breast Cancer in a Nationwide Cohort
CONCLUSION: We identified tumor and ECM features in the primary tumor of patients with de novo OMBC that were associated with long-term survival. Our data should be validated in other patients with OMBC before they can be used in clinical practice.PMID:37738542 | DOI:10.1200/PO.22.00670
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Tessa G Steenbruggen Denise M Wolf Bram Thijssen Joyce Sanders Sten Cornelissen Roberto Salgado Lorenza Mittempergher Rajith Bhaskaran Annegien Broeks Esther H Lips Sabine Siesling Gabe S Sonke Hugo M Horlings Laura J van 't Veer Source Type: research

The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.PMID:37737712 | DOI:10.18632/aging.205051
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Yao Li Xue Meng Yuqing Luo Shuai Luo Jin Li Jiafei Zeng Xiang Huang Jinjing Wang Source Type: research

Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research

FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
In this study, we identified positive as well as negative regulators of Moesin. Our study reveals that Moesin is a cellular target of F-box protein FBXW2. We showed that FBXW2 suppresses breast cancer progression through directing proteasomal degradation of Moesin. In contrast, AKT kinase plays an important role in oncogenic function of Moesin by protecting it from FBXW2-mediated proteasomal degradation. Mechanistically, AKT phosphorylates Moesin at Thr-558 and thereby prevents its degradation by FBXW2 via weakening the association between FBXW2 and Moesin. Further, accumulated Moesin prevents FBXW2-mediated degradation of...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ganesh Kumar Barik Osheen Sahay Anindya Mukhopadhyay Rajesh Kumar Manne Sehbanul Islam Anup Roy Somsubhra Nath Manas Kumar Santra Source Type: research