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Statin Wars: Less-is-More versus Unlimited Medicine
By SARAH JHA, MD
It is the beauty of evidence-based medicine (EBM) that a scientist can at once be a Pope and a Galileo. His transmutation is as effortless as it is discretionary. If you think you’ve met Galileo – a rebel, a free thinker, a rocker of the establishment – the following week he is a Pope, castigating detractors, censoring critics, and celebrating uniformity. He changes by a roll of the dice. His change is decided by a quirk in hypothesis-testing known as statistical significance. If the p value is 0.051 he is Galileo, if the p value is 0.049 he becomes the cardinal. He is one day a raging skepti...
Source: The Health Care Blog - September 20, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
How To Think About Health Technology Assessment: A Response To Goldman And Coauthors
From 3,000 miles away—on the other side of the Atlantic and more precisely from England—it is hard not to sense a note of frustration in the Health Affairs Blog post by Dana Goldman, Sam Nussbaum, and Mark Linthicum: “We need health technology assessment. Only we can’t have it. Because we are us. But we need it. But we can’t have it. So what do we do?”
It is also hard not to offer sympathy, not least because every country that has what the three authors dub “full” health technology assessment (also referred to here as “HTA”) finds it endlessly controversial. But at least some of the dilemma that...
Source: Health Affairs Blog - September 15, 2016 Category: Health Management Authors: Nicholas Timmins Tags: Costs and Spending Drugs and Medical Innovation Featured Health IT Europe health technology assessment National Health Service Source Type: blogs
Rapid Biomedical Innovation Calls For Similar Innovation In Pricing And Value Measurement
Advances in foundational science, technology, and clinical knowledge are driving a revolution in patient care. Minimally invasive surgery has reduced rates of post-surgical complications, reduced hospitalization, and dramatically accelerated recovery; direct-acting antivirals have brought a cure for hepatitis C; and novel immunotherapies have brought the promise of increased survival to late-stage cancer patients. The list goes on.
At the same time, spending on these innovative drugs and devices has increased dramatically. Between 1980 and 2010, overall personal health care expenditures in the US grew nearly four-fold, dri...
Source: Health Affairs Blog - September 15, 2016 Category: Health Management Authors: Dana Goldman, Samuel Nussbaum and Mark Linthicum Tags: Drugs and Medical Innovation Featured Comparative Effectiveness health technology assessment National Health Service National Institute for Health and Care Excellence PCORI Source Type: blogs
How Can The Government Improve Prevention Programs In The Workplace?
In the U.S., over 150 million adults go to work daily and spend the majority of their waking hours engaged in some form of employment. Prior to the passage of the Affordable Care Act (ACA), the federal government had not seriously considered the workplace as an appropriate venue for improving population health, although the Centers for Disease Control and Prevention (CDC) had funded a small number of workplace projects dating back to the mid-1980s.
In a bipartisan manner, the federal government can play a significant role to engage the business community in building and sustaining workplace health promotion programs that w...
Source: Health Affairs Blog - September 2, 2016 Category: Health Management Authors: Ron Goetzel Tags: Costs and Spending Organization and Delivery Population Health Quality health promotion Prevention Workplace Wellness Source Type: blogs
Fight Aging! Newsletter, August 29th 2016
This study demonstrates that TNTs play a significant part in the intercellular transfer of α-synuclein fibrils and reveals the specific role of lysosomes in this process. This represents a major breakthrough in understanding the mechanisms underlying the progression of synucleinopathies. These compelling findings, together with previous reports from the same team, point to the general role of TNTs in the propagation of prion-like proteins in neurodegenerative diseases and identify TNTs as a new therapeutic target to combat the progression of these incurable diseases.
Shorter Period of Rapamycin Treatment in Mice...
Source: Fight Aging! - August 28, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How to Eliminate Innovation Obstacles
Innovation — whether in business, technology or health care delivery — is about figuring out how to do something in a new and better way. To succeed we must overcome challenges and obstacles, and one of the most common challenges is the unknown. Fortunately there are methods and tools for gaining most of the knowledge necessary to innovate; we will discuss some of them in this post.
Into the Unknown
By definition, when you’re innovating, you’re doing something that hasn’t been done before — if not ever, at least by your organization. These things for which you and your organization lack experienc...
Source: Medical Connectivity Consulting - August 25, 2016 Category: Information Technology Authors: Tim Gee Tags: Connectivity Patient Safety Product Development Strategy & Planning Source Type: blogs
The SENS Rejuvenation Research Supporters of the German Party for Health Research to Run in Berlin State Parliament Elections
Single issue political parties are near invisible in the US, thanks to the political duopoly that manifests as an outcome of the use of first-past-the-post election rules. In many European countries more representative voting rules allow for the existence of a much larger number of competing parties, and as a result forming a political party to advance a single issue is a entire viable way to run a long-term advocacy campaign. You only have to look at the many environmentalist Green parties, or the more recent growth of the Pirate party, or even the lasting message provided by the Official Monster Raving Loony Party of the...
Source: Fight Aging! - August 5, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Six Reasons That Justify A ‘Marriage Of Convenience’ Between HIV And Noncommunicable Disease Programs
Another round in the battle to end HIV/AIDS began on June 10, 2016, at United Nations (UN) headquarters in New York, when the HIV community adopted targets and actions to end the AIDS epidemic by 2030. For Sub-Saharan Africa (SSA), which bears the largest burden of HIV deaths (800,000 in 2015), this is the promise of a new dawn.
However, this ambitious goal to improve health for people with HIV will not be fully realized unless health systems in sub-Saharan Africa address another threat that looms large on the horizon: the growing epidemic of chronic noncommunicable diseases (NCDs). These include heart disease, respiratory...
Source: Health Affairs Blog - August 5, 2016 Category: Health Management Authors: Irene Yameogo Ngendakumana and Mohammed K. Ali Tags: Costs and Spending Featured Global Health Public Health HIV/AIDS NCDs sub-saharan africa United Nations Source Type: blogs
Fight Aging! Newsletter, August 1st 2016
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 31, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Review of Telomerase as a Therapeutic Target
Telomerase provides the primary mechanism by which cells lengthen their telomeres. In our species only stem cells and cancer cells do this, while in mice more types of cell use more telomerase. Telomere length determines the limit to cell divisions, a little of the length being lost each time a cell divides. Cells that can lengthen their telomeres can continue dividing indefinitely, and that is how stem cells can continually deliver a useful supply of daughter cells to support surrounding tissues. It is also how cancer grows. Cancer and regeneration are the two sides of the same coin of growth and regeneration, one control...
Source: Fight Aging! - July 30, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Ubl Gets Personal, Lays Out Vision for Future of PhRMA
PhRMA President and CEO Steve Ubl recently joined the Medium blogging website and penned his first post, "Health Care Veteran Gaines New Perspective." The post goes through the struggles his family experienced with chronic disease, and how they have shaped his approach to his role at PhRMA. This post is expected to be the first of many where he will dive into topics such as: PhRMA's policy solutions to deliver innovative treatments to patients, promise in the pipeline, and the biopharmaceutical industry's economic footprint, among many other issues.
Ubl opens his inaugural post by opening up about a phone call he receive...
Source: Policy and Medicine - July 28, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Fight Aging! Newsletter, July 25th 2016
This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke.
To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti...
Source: Fight Aging! - July 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aubrey de Grey AMA at /r/Futurology: the SENS Approach to Cancer and More
Today, July 19th, Aubrey de Grey of the SENS Research Foundation and Haroldo Silva, lead SENS cancer researcher, are hosting an AMA - Ask Me Anything - event at /r/futurology. They will be there for a few hours to answer questions on rejuvenation research, fundraising for work on aging and cancer, and other aspects of the work of the SENS Research Foundation. This is a chance to ask about the SENS approach to a universal cancer therapy, one that targets the common mechanism of telomere lengthening that all cancers must employ to grow. The SENS researchers are focused on alternative lengthening of telomeres, ALT, a collecti...
Source: Fight Aging! - July 19, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Proposed Drug and Device Laws Should Be Pushed to 2017
By PAUL BROWN, TRACY RUPP, and STEVEN FINDLAY
Senate leaders now say they won’t consider companion legislation to the House-passed 21st Century Cures Act until September, after months of delay. Lawmakers would then have to reconcile the differing House and Senate versions, presumably by year’s end during a lame-duck Congress.
We believe the summer delay is a good thing, and that Congress should actually extend consideration of the complex legislation into 2017 when must-pass FDA funding through industry user-fees will be on the congressional calendar. That way, lawmakers can debate the implications of the propos...
Source: The Health Care Blog - July 14, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized 21st Century Cures Act Consumer's Union FDA User Fees Medical Devices Steven Findlay Source Type: blogs
So Much Talk, So Little Walk on Quality
By CECI CONNOLLY
Quality is all the rage in health care these days. It rolls off the presidential tongue and is at the heart of robust targets set by Health and Human Services Secretary Sylvia Burwell. (No less than half of all Medicare payments to be quality based by the end of 2018!)
“We’re moving Medicare toward a payment model that rewards quality of care instead of quantity of care,” President Obama declared at a March 2015 summit dedicated to alternative payment models that move away from volume-based, fee-for-service payment
Industry is on the rhetorical bandwagon too. A quick search for the word quality on ...
Source: The Health Care Blog - July 11, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
