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More on clinical trials
Previously, I discussed the basic concept of randomized controlled trials, but didn ' t go into all the complexities. Actually, I can ' t go intoallthe complexities without writing a very big book, and that ' s not the book I want to write. However, there are some important points I ' d like to cover here.First, there ' s the question of what drugs (or possibly other kinds of interventions) even get into clinical trials in the first place. In order to conduct trials, the sponsor needs to get approval of what ' s called an Investigational New Drug Application from the FDA. This requires a reasonable expectation of safety an...
Source: Stayin' Alive - February 18, 2021 Category: American Health Source Type: blogs
What ’s behind racial disparities in kidney disease?
My first exposure to kidney disease and its impact on communities of color occurred when I was in high school. An elderly neighbor, who was like a grandfather to me, had been diagnosed with kidney failure. At about the same time, my older first cousin, who had children about my age, was starting dialysis due to kidney failure attributed to hypertension. She would go on to get a kidney transplant. If you ask any African American, he or she is likely to have at least one relative with kidney disease requiring dialysis or transplantation.
Disparities in kidney disease not noted in medical literature until early 1980s
When I b...
Source: Harvard Health Blog - February 3, 2021 Category: Consumer Health News Authors: J. Kevin Tucker, MD Tags: Health care disparities Kidney and urinary tract Source Type: blogs
Fight Aging! Newsletter, February 1st 2021
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSCs). We report increased frequencies of HSC, hematopoetic progenitor cells (HPC), and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics. The activity of the small RhoGTPase Cdc42 was elevated in aged human hematopoietic cells and we identified a positive correlation between Cdc42 activity and the frequency of HSCs upon aging.
The frequency of human HSCs polar fo...
Source: Fight Aging! - January 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Are early detection and treatment always best?
Throughout my medical career, I’ve heard statements like these:
Early detection offers the best chance of cure.
If you wait for symptoms, you’ve waited too long.
Knowledge is power, and the sooner you have the information, the better.
Over time, I’ve realized they are often untrue. Many health conditions go away on their own. In such cases, early testing may amount to wasted effort, time, and medical cost. Some testing is invasive and has a significant risk of complications. And minor abnormalities may lead to more testing. There’s also the anxiety of waiting for results, or learning you have an abnormality of unce...
Source: Harvard Health Blog - January 28, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Back Pain Heart Health Managing your health care Prevention Screening Tests and procedures Source Type: blogs
Fight Aging! Newsletter, January 25th 2021
In conclusion, our studies highlight the important role of the tyrosine degradation pathway and position TAT as a link between neuromediator production, dysfunctional mitochondria, and aging.
Source: Fight Aging! - January 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Considering the Ethics of Extending the Healthy Human Life Span
To suffer or become incapacitated is to diminish the utility of being alive. The way to minimize this loss is to work towards removing the causes of suffering and incapacitation. The greatest such causes are medical, and of those, aging is by far the largest. Similarly, to die is to suffer the loss of all that one might have been and done after that time. It is a tragedy that any individual ceases to exist. The way to minimize this loss is to work to remove the causes of death. The greatest such causes are medical, and of those, aging is by far the largest. Ethically, the case for working to extend healthy human life spans...
Source: Fight Aging! - January 19, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why Won ’t the Doctor Do More Tests on Older Parent?
Photo Credit Unsplash
Dear Carol: My mom is 78 and she’s thrilled because her doctor told her that since she’s over 75, she’s done with taking colonoscopies and “a bunch of other tests.” I was alarmed, but she said that there’s not a lot of good to be gotten from the tests at her age, and there are risks in having them. Mom is healthy and I want to keep her that way. What if she develops colon cancer? Granted, she has no sign of any problem with her test last year, but the possibility still worries me. Is this policy just to save the health insurance companies money or is this ageism because older people ...
Source: Minding Our Elders - January 17, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
How to avoid 5 common mistakes that can lead to large medical bills
Even if you have a great health insurance plan, you may be faced with large unexpected medical bills that can significantly impact your finances and may lead to medical debt. High deductible plans, the rising cost of care, and high-cost treatments for conditions ranging from cancer to COVID-19 can put almost anyone at risk for […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - January 12, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/miles-j-varn" rel="tag" > Miles J. Varn, MD < /a > < /span > Tags: Physician Practice Management Primary Care Source Type: blogs
Getting a second opinion can save lives. It is time we make Miranda rights for patients.
The Lebanese-born former American oncologist Farid Fata committed one of the most malicious acts of greed by a medical professional in recorded history. Fata spent six years telling otherwise healthy people that they had cancer and needed immediate chemotherapy. He then fraudulently billed over $34 million in charges to Medicare and private insurance companies. Fata […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - December 27, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/robert-trent" rel="tag" > Robert Trent < /a > < /span > Tags: Physician Primary Care Source Type: blogs
Podcast: From Divorce to Besties
How did Gabe and Lisa go from being spouses to divorcees to best friends? Do they hold any residual anger toward each other? Hurt feelings? Secret attraction? How do their current spouses feel about their friendship?
If you’re curious to understand their unique journey, join us as they tell all on today’s podcast.
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About The Not Crazy podcast Hosts
Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular book, Mental Illness is an Asshole and other Observations...
Source: World of Psychology - December 15, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Friends General Marriage and Divorce Not Crazy Podcast Relationships Source Type: blogs
Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging.
Senescent Cells Fail to Maintain Proteostasis
https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/
Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pla...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CRAZY AMERICA: Health Insurance Covers Testing When You Are Well But Not When You Are Sick
By HANS DUVEFELT
Insurance is the wrong word for what we have here. Our private health insurance system’s prioritization of sometimes frivolous screenings but non-coverage for common illnesses and emergencies is a travesty and an insult to typical American middle class families.
State Medicaid insurance for the underemployed has minimal copays of just a few dollars for doctor visits and medications. From my vantage point as a physician, it is the best insurance a patient can have. They cover almost everything and it is clear to me how to apply for exceptions or follow their step care requirements. I cannot...
Source: The Health Care Blog - December 9, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options a...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Will Shape Joe Biden ’s Health Care Agenda?
I’m thrilled to have health futurist Jeff Goldsmith back on THCB, and given Biden was only confirmed as President-elect this morning, his article on what to expect is extremely timely!–Matthew Holt
By JEFF GOLDSMITH
The Trump administration’s health care journey began with a trillion dollar near miss–the failed Repeal and Replacement of ObamaCare- and ended with a full-on train wreck, the catastrophically mismanaged COVID epidemic that will have claimed 300,000 lives by the time he leaves office. After four years of posturing and lethal incompetence, it will be a relief to see caring and pr...
Source: The Health Care Blog - November 7, 2020 Category: Consumer Health News Authors: matthew holt Tags: Health Policy OP-ED Politics THCB ACA Biden Jeff Goldsmith States Unions Source Type: blogs
Election Issue Spotlight: “Junk” Insurance Makes a Pandemic Even Worse
By ROSEMARIE DAY and NIKO LEHMAN-WHITE
One of the most important responsibilities of the American government is to protect its citizens from harmful industry practices, from lead poisoning to dangerous pharmaceuticals to financial meltdowns. Its record is far from perfect, but government regulators usually act in good faith and in turn earn the trust of those they protect. As we head into Tuesday’s election, it’s important to shine a spotlight on the fact that the Trump administration has betrayed that trust yet again. They have allowed low-quality, unregulated forms of insurance called Short-Term Limited Du...
Source: The Health Care Blog - October 30, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Politics election 2020 Health insurance niko lehman-white rosemarie day Source Type: blogs
